carbapenems

Summary

Summary: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.

Top Publications

  1. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
  2. ncbi Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options
    Marie Kempf
    Aix Marseille University, URMITE CNRS IRD, UMR 6236, Faculte de Medecine et de Pharmacie, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Antimicrob Agents 39:105-14. 2012
  3. ncbi Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    Gopi Patel
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Infect Control Hosp Epidemiol 29:1099-106. 2008
  4. pmc Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae
    H Yigit
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 45:1151-61. 2001
  5. ncbi Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention
    Neil Gupta
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A 35, Atlanta, GA 30333, USA
    Clin Infect Dis 53:60-7. 2011
  6. ncbi Bloodstream infections caused by metallo-β-lactamase/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes
    Eleni Mouloudi
    Intensive Care Unit, Hippokration General Hospital, Thessaloniki, Greece
    Infect Control Hosp Epidemiol 31:1250-6. 2010
  7. pmc Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii
    Jubelle K Valenzuela
    Centre for Infectious Diseases and Microbiology, University of Sydney, New South Wales, Australia
    J Clin Microbiol 45:453-60. 2007
  8. ncbi Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium
    Simona Bratu
    Division of Infectious Diseases, State University of New York Downstate, Brooklyn, NY 11203, USA
    Arch Intern Med 165:1430-5. 2005
  9. ncbi Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options
    Lisa L Maragakis
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 46:1254-63. 2008
  10. pmc Carbapenems: past, present, and future
    Krisztina M Papp-Wallace
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 55:4943-60. 2011

Detail Information

Publications320 found, 100 shown here

  1. ncbi The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria
    Patrice Nordmann
    Service de Bactériologie Virologie Hygiène, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine and Université Paris Sud, K Bicêtre, France
    Lancet Infect Dis 9:228-36. 2009
    ..b>Carbapenems (imipenem, meropenem, and ertapenem) may thus become inefficient for treating enterobacterial infections with ..
  2. ncbi Emergence of resistance to carbapenems in Acinetobacter baumannii in Europe: clinical impact and therapeutic options
    Marie Kempf
    Aix Marseille University, URMITE CNRS IRD, UMR 6236, Faculte de Medecine et de Pharmacie, Université de Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Int J Antimicrob Agents 39:105-14. 2012
    ..baumannii isolates to the last-line antibiotics carbapenems and colistin, therapeutic options are very limited or absent in some cases of infections with pandrug-resistant ..
  3. ncbi Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies
    Gopi Patel
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Infect Control Hosp Epidemiol 29:1099-106. 2008
    ..Carbapenem-resistant Klebsiella pneumoniae is an emerging healthcare-associated pathogen...
  4. pmc Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae
    H Yigit
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 45:1151-61. 2001
    ..Hydrolysis studies showed that purified KPC-1 hydrolyzed not only carbapenems but also penicillins, cephalosporins, and monobactams. KPC-1 had the highest affinity for meropenem...
  5. ncbi Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention
    Neil Gupta
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, 1600 Clifton Road NE, MS A 35, Atlanta, GA 30333, USA
    Clin Infect Dis 53:60-7. 2011
    ..As a result, preventing both CRE transmission and CRE infections have become important public health objectives. This review describes the current epidemiology of CRE in the United States and highlights important prevention strategies...
  6. ncbi Bloodstream infections caused by metallo-β-lactamase/Klebsiella pneumoniae carbapenemase-producing K. pneumoniae among intensive care unit patients in Greece: risk factors for infection and impact of type of resistance on outcomes
    Eleni Mouloudi
    Intensive Care Unit, Hippokration General Hospital, Thessaloniki, Greece
    Infect Control Hosp Epidemiol 31:1250-6. 2010
    ..pneumoniae carbapenemases (KPCs), as well as risk factors for mortality associated with carbapenem-resistant K. pneumoniae, among intensive care unit (ICU) patients...
  7. pmc Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii
    Jubelle K Valenzuela
    Centre for Infectious Diseases and Microbiology, University of Sydney, New South Wales, Australia
    J Clin Microbiol 45:453-60. 2007
    ..Epidemiological investigation of major outbreaks should include whole-genome typing as well as analysis of potentially transmissible resistance genes and their vehicles...
  8. ncbi Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium
    Simona Bratu
    Division of Infectious Diseases, State University of New York Downstate, Brooklyn, NY 11203, USA
    Arch Intern Med 165:1430-5. 2005
    ..In this study, the prevalence and molecular epidemiologic characteristics of carbapenem-resistant K pneumoniae are analyzed, and the experience involving 2 hospital outbreaks is described...
  9. ncbi Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options
    Lisa L Maragakis
    Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Infect Dis 46:1254-63. 2008
    ....
  10. pmc Carbapenems: past, present, and future
    Krisztina M Papp-Wallace
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 55:4943-60. 2011
    ..Among the β-lactams currently available, carbapenems are unique because they are relatively resistant to hydrolysis by most β-lactamases, in some cases act as "..
  11. ncbi Impact of revised CLSI breakpoints for susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates in the Asia-Pacific region: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART), 2002-2010
    Chi Chang Huang
    Department of Internal Medicine, National Cheng Kung University Hospital, No 138, Sheng Li Road, Tainan 704, Taiwan
    Int J Antimicrob Agents 40:S4-10. 2012
    This study examined the rates of susceptibility to third-generation cephalosporins and carbapenems among Enterobacteriaceae isolates that had been obtained from patients with intraabdominal infections in the Asia-Pacific region as part ..
  12. pmc Emergence of NDM-1 metallo-β-lactamase in Pseudomonas aeruginosa clinical isolates from Serbia
    Branko Jovcic
    Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia
    Antimicrob Agents Chemother 55:3929-31. 2011
    ..Five additional isolates from different patients clonally related to either MMA83 or MMA533 were found to be NDM-1 positive...
  13. pmc Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins
    Vincent Dubée
    Centre de Recherche des Cordeliers, LRMA, Equipe 12, Universite Pierre et Marie Curie Paris 6, UMR S 872, Paris, France
    Antimicrob Agents Chemother 56:4189-95. 2012
    ..b>Carbapenems inactivate these l,d-transpeptidases, and meropenem combined with clavulanic acid is bactericidal against ..
  14. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    ..coli isolates emerged in ICUs in our hospital. KPC-2 combined with porin deficiency results in high-level carbapenem resistance in K. pneumoniae. The same bla(KPC-2)-encoding plasmid was spread among the three different genera...
  15. pmc Impact of carbapenem resistance and receipt of active antimicrobial therapy on clinical outcomes of Acinetobacter baumannii bloodstream infections
    John S Esterly
    Department of Pharmacy Practice, Chicago State University College of Pharmacy, Chicago, Illinois, USA
    Antimicrob Agents Chemother 55:4844-9. 2011
    ..Inactive therapy was more important than carbapenem susceptibility with respect to outcomes, was a strong predictor of death, and is potentially modifiable...
  16. pmc Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds
    Y Arakawa
    Department of Bacterial Products, National Institute of Infectious Diseases, Tokyo, Japan
    J Clin Microbiol 38:40-3. 2000
    ..The specificity and sensitivity of this test were comparable to those of PCR analysis using bla(IMP)-specific primers. Therefore, this convenient test would be valuable for daily use in clinical laboratories...
  17. pmc Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China
    Ze Qing Wei
    Key Laboratory of Infectious Diseases of the Public Health Ministry, 1st Affiliated Hospital, Medical School, Zhejiang University, Hangzhou, Zhejiang, China
    Antimicrob Agents Chemother 51:763-5. 2007
    ..The KPC-2 gene was located on an approximately 60-kb plasmid in a genetic environment partially different from that of blaKPC-2 in the isolates from the United States and Colombia...
  18. ncbi Characteristics of carbapenem-resistant Enterobacteriaceae isolates from Korea
    So Yeon Kim
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, Korea
    Diagn Microbiol Infect Dis 76:486-90. 2013
    ..pneumoniae isolates (ST340) was determined. Polymyxin- and tigecycline-resistant CRE isolates were also identified, which limits treatment options for infections causes by these organisms. ..
  19. ncbi AbaR4 replaces AbaR3 in a carbapenem-resistant Acinetobacter baumannii isolate belonging to global clone 1 from an Australian hospital
    Mohammad Hamidian
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    J Antimicrob Chemother 66:2484-91. 2011
    ..To explore the diversity of genomic resistance islands in multiply antibiotic-resistant Acinetobacter baumannii isolates in global clone 1 (GC1) from Australian hospitals...
  20. ncbi Potential role of active surveillance in the control of a hospital-wide outbreak of carbapenem-resistant Klebsiella pneumoniae infection
    Debby Ben-David
    Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer, Israel
    Infect Control Hosp Epidemiol 31:620-6. 2010
    ..The recent emergence of carbapenem resistance among Enterobacteriaceae is a major threat for hospitalized patients, and effective strategies are needed...
  21. ncbi Wide dissemination of OXA-23-producing carbapenem-resistant Acinetobacter baumannii clonal complex 22 in multiple cities of China
    Yiqi Fu
    Department of Respiratory Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, People s Republic of China
    J Antimicrob Chemother 65:644-50. 2010
    ..In this study, multilocus sequence typing (MLST) was used to describe the genetic backgrounds of carbapenem-resistant Acinetobacter baumannii (CRAB) and carbapenem-susceptible A. baumannii (CSAB) from multiple cities of China...
  22. pmc National surveillance study on carbapenem non-susceptible Klebsiella pneumoniae in Taiwan: the emergence and rapid dissemination of KPC-2 carbapenemase
    Sheng Kang Chiu
    Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    PLoS ONE 8:e69428. 2013
    ..To establish nationwide data on CnSKP spread and carbapenem-resistance mechanisms, we conducted a national surveillance study in Taiwanese hospitals...
  23. ncbi Carriage rate of carbapenem-resistant Klebsiella pneumoniae in hospitalised patients during a national outbreak
    Y Wiener-Well
    Infectious Disease Unit, Shaare Zedek Medical Center, Jerusalem, affiliated with the Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Hosp Infect 74:344-9. 2010
    ..4%. The clonal origin of these isolates suggests that strict adherence to isolation procedure may contain this outbreak...
  24. pmc Treatment and outcomes in carbapenem-resistant Klebsiella pneumoniae bloodstream infections
    Elizabeth A Neuner
    Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA
    Diagn Microbiol Infect Dis 69:357-62. 2011
    ..In summary, CR-Kp bloodstream infections occur in patients who are chronically and acutely ill. They are associated with high 14-day mortality and poor outcomes regardless of tigecycline or other treatment regimens selected...
  25. ncbi Multidrug-resistant Gram-negative infections: what are the treatment options?
    Helen Giamarellou
    4th Department of Internal Medicine, Athens University School of Medicine, ATTIKON University Hospital of Athens, Athens, Greece
    Drugs 69:1879-901. 2009
    ..Finally, doripenem, the recently licensed member of the carbapenems (without significant spectrum alterations from the ascendant members) seems to possess a lower potential for ..
  26. pmc Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of beta-lactamases
    G Bou
    Servicio de Microbiologia, Hospital Ramon y Cajal, 28034 Madrid, Spain
    J Clin Microbiol 38:3299-305. 2000
    ....
  27. ncbi Insights into the global molecular epidemiology of carbapenem non-susceptible clones of Acinetobacter baumannii
    Nabil Karah
    Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
    Drug Resist Updat 15:237-47. 2012
    ..cause outbreaks of infections and to acquire resistance to almost all currently used antibiotics, including the carbapenems. This review considers the literature on A...
  28. ncbi Emergence and spread of carbapenem-resistant strains of Acinetobacter baumannii in a tertiary-care hospital in Poland
    M M Wroblewska
    Department of Medical Microbiology, Central Clinical Hospital, Medical University of Warsaw, Warsaw, Poland
    Clin Microbiol Infect 13:490-6. 2007
    ..The occurrence of a VIM-type MBL in association with one of the epidemic lineages of A. baumannii is a cause for concern. Further studies are needed to evaluate possible inter-hospital spread of resistant A. baumannii strains in Poland...
  29. pmc High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe
    Frank M Kaczmarek
    Pfizer Global Research and Development, Groton, CT 06340, USA
    Antimicrob Agents Chemother 50:3396-406. 2006
    Clinical isolates of Klebsiella pneumoniae resistant to carbapenems and essentially all other antibiotics (multidrug resistant) are being isolated from some hospitals in New York City with increasing frequency. A highly related pair of K...
  30. ncbi Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-beta-lactamase
    J H Toney
    Department of Biochemistry, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065 0900, USA
    Chem Biol 5:185-96. 1998
    ..Co-administration of metallo-beta-lactamase inhibitors to resistant bacteria is expected to restore the antibacterial activity of carbapenems.
  31. ncbi Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: a systematic review and meta-analysis
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Greece
    Clin Infect Dis 56:272-82. 2013
    We sought to study whether the better pharmacokinetic and pharmacodynamic (PK/PD) properties of carbapenems and piperacillin/tazobactam, when the duration of infusion is longer, were associated with lower mortality...
  32. ncbi Risk factors for the acquisition of carbapenem-resistant Escherichia coli among hospitalized patients
    Min Hyok Jeon
    Department of Infectious Diseases, University of Soonchunhyang College of Medicine, Choongchungnam do 336 745, Republic of Korea
    Diagn Microbiol Infect Dis 62:402-6. 2008
    ..Our results suggest that the nosocomial acquisition of CREC may be favored by the selection pressure of carbapenems and metronidazole and also related to prior hospital stay and the presence of biliary drainage catheter.
  33. pmc Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination
    Federico Perez
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Antimicrob Chemother 65:1807-18. 2010
    Resistance to carbapenems among Acinetobacter baumannii and Klebsiella pneumoniae presents a serious therapeutic and infection control challenge. We describe the epidemiology and genetic basis of carbapenem resistance in A...
  34. pmc First detection of the plasmid-mediated class A carbapenemase KPC-2 in clinical isolates of Klebsiella pneumoniae from South America
    Maria Virginia Villegas
    CIDEIM International Center for Medical Research and Training, Cali, Colombia
    Antimicrob Agents Chemother 50:2880-2. 2006
    ..These KPC enzymes are the first from South America and the second isolation outside of the United States. The expanding geographic spread of KPC carbapenemases underscores the importance of clinical recognition of these enzymes...
  35. pmc Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland
    Katarzyna Zacharczuk
    Department of Bacteriology, National Institute of Public Health National Institute of Hygiene, Warsaw, Poland
    Antimicrob Agents Chemother 55:443-6. 2011
    ..XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.
  36. ncbi Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in a German university medical centre
    Anke Kohlenberg
    Institute of Hygiene and Environmental Medicine, Charite University Medicine, Hindenburgdamm 27, 12203 Berlin, Germany
    J Med Microbiol 58:1499-507. 2009
    ..baumannii and cohorting of patients. This is believed to be the first report of an outbreak of A. baumannii carrying the carbapenemase OXA-23 in Germany...
  37. ncbi Clinical epidemiology of carbapenem-intermediate or -resistant Enterobacteriaceae
    Nimish Patel
    Pharmacy Practice Department, Albany College of Pharmacy and Health Sciences, Albany, NY 12208 3492, USA
    J Antimicrob Chemother 66:1600-8. 2011
    ..This study characterizes factors associated with CIRE among two different source populations...
  38. pmc Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine
    Michael J Satlin
    Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA
    Antimicrob Agents Chemother 55:5893-9. 2011
    ..Treatment with an aminoglycoside, when active in vitro, was associated with a significantly higher rate of microbiologic clearance of CRKP bacteriuria than treatment with either polymyxin B or tigecycline...
  39. ncbi Widespread carbapenem resistant Acinetobacter baumannii clones in Italian hospitals revealed by a multicenter study
    E Carretto
    S C Microbiologia, A O Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
    Infect Genet Evol 11:1319-26. 2011
    Population diversity, susceptibility to antibiotics including carbapenems of 277 Acinetobacter baumannii strains collected in 17 Italian hospitals over a 6-months' period was assessed...
  40. ncbi Emerging carbapenemases: a global perspective
    Timothy R Walsh
    Cardiff University, Heath Park Hospital, UK
    Int J Antimicrob Agents 36:S8-14. 2010
    ..In particular, the media attention given to the NDM-1 metallo-β-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance...
  41. pmc Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:3849-54. 2011
    ..S. hospitals constitute part of the global epidemic driven by CC92, but have unique STs other than ST92, which may be spreading by means of patient transfer between health care facilities within the United States...
  42. ncbi Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns
    Khetam Hussein
    Infectious Diseases Unit, Rambam Medical Center, Haifa, Israel
    Infect Control Hosp Epidemiol 30:666-71. 2009
    ..Carbapenem resistance among isolates of Klebsiella pneumoniae has been unusual...
  43. pmc Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory
    Clare Franklin
    Microbiology Unit, Alfred Pathology Service, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    J Clin Microbiol 44:3139-44. 2006
    ..Early detection of MBL-carrying organisms, including those with susceptibility to carbapenems, is of paramount clinical importance, as it allows rapid initiation of strict infection control practices as ..
  44. ncbi Risk factors of carbapenem-resistant Klebsiella pneumoniae infections: a matched case control study
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    J Antimicrob Chemother 60:1124-30. 2007
    b>Carbapenems are frequently used to treat infections due to extended-spectrum beta-lactamase-producing Klebsiella pneumoniae. Thus, the emergence of infections due to carbapenem-resistant K...
  45. pmc Complete sequence of a novel 178-kilobase plasmid carrying bla(NDM-1) in a Providencia stuartii strain isolated in Afghanistan
    Patrick McGann
    Multidrug Resistant Organism Repository and Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Antimicrob Agents Chemother 56:1673-9. 2012
    ..The presence of multiple insertion sequences and transposons flanking the region containing the bla(NDM-1) gene further highlights the potential mobility associated with this gene...
  46. pmc First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase
    Maria Virginia Villegas
    CIDEIM, International Center for Medical Research and Training, Cali, Colombia
    Antimicrob Agents Chemother 51:1553-5. 2007
    ..This is the first report of a KPC-type beta-lactamase identified outside of the family Enterobacteriaceae...
  47. ncbi Carbapenem-resistant versus carbapenem-susceptible Acinetobacter baumannii bacteremia in a Greek intensive care unit: risk factors, clinical features and outcomes
    C Routsi
    1st Department of Intensive Care, Evangelismos Hospital, University of Athens Medical School, 45 47 Ipsilantou Str, 106 76, Athens, Greece
    Infection 38:173-80. 2010
    ..The objective of this study was to determine specific risk factors for and outcome of bacteremia due to CRAB isolates among our ICU patients with A. baumannii bacteremia...
  48. pmc Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality
    Mitchell J Schwaber
    Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1028-33. 2008
    ..6; and P = 0.03; for the CRKP group versus the controls, OR, 5.0; 95% CI, 1.7 to 14.8; and P = 0.004). CRKP affects patients with poor functional status, an ICU stay, and antibiotic exposure and is an independent predictor of death...
  49. pmc Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York Medical Center
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Specialist and Reference Microbiology Division Colindale, Health Protection Agency, London, United Kingdom
    Antimicrob Agents Chemother 48:4793-9. 2004
    ..Although producers of these enzymes remain rare, the progress of this enzyme group merits monitoring...
  50. ncbi Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina
    S Brown
    Department of Medical Microbiology, Edinburgh University Medical School, Edinburgh
    Clin Microbiol Infect 11:15-23. 2005
    ..b>Carbapenems are the remaining drugs of choice in many centres, but carbapenem resistance is now emerging in strains ..
  51. pmc Novel genetic environment of the carbapenem-hydrolyzing beta-lactamase KPC-2 among Enterobacteriaceae in China
    Ping Shen
    State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China
    Antimicrob Agents Chemother 53:4333-8. 2009
    ..The chimera of several transposon-associated elements indicated a novel genetic environment of the K. pneumoniae carbapenemase beta-lactamase gene in isolates from China...
  52. pmc Spread of OXA-48-encoding plasmid in Turkey and beyond
    Amélie Carrër
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 54:1369-73. 2010
    ..That gene was located within either transposon Tn1999 or transposon Tn1999.2, which was always inserted within the same gene. This work highlights the current plasmid-mediated dissemination of the OXA-48 carbapenemase worldwide...
  53. pmc Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob
    Stephen P Hawser
    IHMA Europe Sàrl, 4 Route de la Corniche, 1066 Epalinges, Switzerland
    Antimicrob Agents Chemother 54:3043-6. 2010
    ..0% versus 6.5%, respectively, for E. coli (P < 0.001) and 20.9% versus 5.3%, respectively, for K. pneumoniae (P < 0.01). Carbapenems were consistently the most active drugs tested.
  54. ncbi Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004)
    Lalitagauri M Deshpande
    JMI Laboratories, North Liberty, Iowa, USA
    Microb Drug Resist 12:223-30. 2006
    ....
  55. ncbi Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City
    Patricia A Bradford
    Wyeth Research, Pearl River, NY, USA
    Clin Infect Dis 39:55-60. 2004
    ..Carbapenem-resistant Klebsiella species possessing KPC-2 are endemic in New York City. This study documents the identification of an inhibitor-resistant TEM beta -lactamase in the United States...
  56. pmc Roles of beta-lactamases and porins in activities of carbapenems and cephalosporins against Klebsiella pneumoniae
    L Martinez-Martinez
    Department of Microbiology, School of Medicine, University of Seville, Seville, Spain
    Antimicrob Agents Chemother 43:1669-73. 1999
    ..In K. pneumoniae porin loss can thus augment resistance provided either by TEM- or SHV-type ESBLs or by plasmid-mediated AmpC enzymes to include the latest oxyimino-beta-lactams and carbapenems.
  57. ncbi Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden
    Ørjan Samuelsen
    Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway
    J Antimicrob Chemother 63:654-8. 2009
    ..This report describes the first KPC-producing Klebsiella pneumoniae isolates identified in Norway (n=6) and the second isolate from Sweden...
  58. pmc Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome
    Isabel Sánchez-Romero
    Servicio de Microbiologia, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
    Antimicrob Agents Chemother 56:420-7. 2012
    ..A high rate of associated mortality and great difficulty in controlling the spread of this clone, without permanent behavioral changes in the personnel, were observed...
  59. ncbi Outbreak of carbapenem-resistant Klebsiella pneumoniae producing KPC-3 in a tertiary medical centre in Israel
    Zmira Samra
    Laboratory of Clinical Microbiology, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa 49100, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Antimicrob Agents 30:525-9. 2007
    ..All the outbreak isolates were resistant to all fluoroquinolones and beta-lactam antibiotics tested, including carbapenems, and were sensitive only to colistin, gentamicin and most of them also to tigecycline...
  60. ncbi Outbreak of Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae with high qnr prevalence in a Chinese hospital
    Rong Zhang
    2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou 310009, PR China
    J Med Microbiol 60:977-82. 2011
    ..PFGE analysis indicated that the 40 strains were all closely related. The MICs of carbapenems varied from 16 to >256 µg ml⁻¹...
  61. ncbi Reduced susceptibility to carbapenems in Klebsiella pneumoniae clinical isolates associated with plasmid-mediated beta-lactamase production and OmpK36 porin deficiency
    Xuan Ding Wang
    2nd Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou 310009, PR China
    J Med Microbiol 58:1196-202. 2009
    ..pneumoniae Z2554 and Z2110. OmpK36 may play an important role in the resistance or reduced susceptibility to carbapenems in K. pneumoniae producing AmpC, extended-spectrum beta-lactamase or broad-spectrum beta-lactamase.
  62. pmc Genetic features of the widespread plasmid coding for the carbapenemase OXA-48
    Laurent Poirel
    Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
    Antimicrob Agents Chemother 56:559-62. 2012
    ..Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids...
  63. pmc Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre, France
    Antimicrob Agents Chemother 44:891-7. 2000
    ..and a broad substrate hydrolysis range, including penicillins, cephalosporins, cephamycins, oxacephamycins, and carbapenems, but not monobactams...
  64. ncbi Clinical impact and risk factors for colonization with extended-spectrum β-lactamase-producing bacteria in the intensive care unit
    Keyvan Razazi
    Université Paris Est Créteil, INSERM U955, Creteil, France
    Intensive Care Med 38:1769-78. 2012
    ..of extended spectrum beta-lactamases (ESBL), the spread to the community and the need for prudent use of carbapenems require updated knowledge of risk factors for colonization with ESBL-producing enterobacteriaceae (ESBL-PE).
  65. ncbi Differences in carbapenem resistance genes among Acinetobacterbaumannii, Acinetobacter genospecies 3 and Acinetobacter genospecies 13TU in Taiwan
    Yu Chi Lin
    Research and Diagnostic Center, Centers for Disease Control, No 161 Kun Yang Street, 11561 Taipei, Taiwan
    Int J Antimicrob Agents 35:439-43. 2010
    ..Of the 81 isolates, 40 (49%) were resistant to carbapenems. Most A. baumannii isolates (47/53, 88...
  66. ncbi Trends in resistance to carbapenems and third-generation cephalosporins among clinical isolates of Klebsiella pneumoniae in the United States, 1999-2010
    Nikolay P Braykov
    Center for Disease Dynamics, Economics and Policy, Washington, DC 20036, USA
    Infect Control Hosp Epidemiol 34:259-68. 2013
    ..We examined national trends in the proportion of Klebsiella pneumoniae isolates resistant to carbapenems (CRKP) and third-generation cephalosporins (G3CRKP).
  67. ncbi Risk factors for the acquisition of carbapenem-resistant Klebsiella pneumoniae among hospitalized patients
    Yee Gyung Kwak
    Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan, Seoul, Korea
    Microb Drug Resist 11:165-9. 2005
    ..26; 95% CI 0.07-0.97); however, the possibility of selection bias cannot be ruled out. Our results suggest that the nosocomial isolation of CRKP is strongly favored by the selection pressure of carbapenem...
  68. ncbi Emergence of Escherichia coli sequence type 410 (ST410) with KPC-2 β-lactamase
    Angeliki Mavroidi
    Department of Microbiology, University Hospital of Larissa, Larissa, Greece
    Int J Antimicrob Agents 39:247-50. 2012
    ..coli ST410 known to be associated with CTX-M production. Diffusion of bla(KPC-2) in common pathogens such as E. coli is of concern...
  69. ncbi High prevalence of OXA-143 and alteration of outer membrane proteins in carbapenem-resistant Acinetobacter spp. isolates in Brazil
    Anna Karina Mostachio
    Laboratory of Bacteriology LIM 54, Hospital das Clinicas, Medical School of the University of São Paulo, Sao Paulo, Brazil
    Int J Antimicrob Agents 39:396-401. 2012
    ..Isolates were identified by API20NE. Minimum inhibitory concentrations (MICs) for carbapenems were determined by broth microdilution...
  70. ncbi Ertapenem resistance among Klebsiella and Enterobacter submitted in the UK to a reference laboratory
    Neil Woodford
    Antibiotic Resistance Monitoring and Reference Laboratory, Centre for Infections, Health Protection Agency, London NW9 5EQ, UK
    Int J Antimicrob Agents 29:456-9. 2007
    ..or an AmpC enzyme in Enterobacter spp. - plus impermeability and/or increased efflux. Imipenem and meropenem often remain moderately active against isolates with low-level ertapenem resistance...
  71. ncbi Emergence of carbapenem-resistant clinical Enterobacteriaceae isolates from a teaching hospital in Shanghai, China
    Fupin Hu
    Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, PR China
    J Med Microbiol 61:132-6. 2012
    b>Carbapenems such as imipenem and meropenem are first-line agents for the treatment of serious nosocomial infections caused by multidrug-resistant clinical isolates of bacteria belonging to the family Enterobacteriaceae...
  72. pmc Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    Antimicrob Agents Chemother 50:3098-101. 2006
    ..This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States...
  73. pmc Phenotypic screening of carbapenemases and associated β-lactamases in carbapenem-resistant Enterobacteriaceae
    André Birgy
    Laboratoire de Microbiologie, Hopital Robert Debre, Assistance Publique des Hopitaux de Paris, Paris, France
    J Clin Microbiol 50:1295-302. 2012
    ..of specific inhibitors, regardless of the carbapenem MICs and including isolates with low-level resistance to carbapenems. We also detected their associated β-lactam resistance mechanisms (11 ESBL-type and 5 class A β-lactamase 2b)...
  74. ncbi Carbapenem-resistant Klebsiella pneumoniae bacteremia: factors correlated with clinical and microbiologic outcomes
    May Nguyen
    Department of Pharmacy, NewYork Presbyterian Hospital, Columbia University Medical Center, New York, NY 10032, USA
    Diagn Microbiol Infect Dis 67:180-4. 2010
    ..Our data suggest that severity of illness, rapid microbiologic eradication, and source control are crucial factors in the outcomes of patients with CRKP bacteremia...
  75. pmc In vitro potentiation of carbapenems with ME1071, a novel metallo-beta-lactamase inhibitor, against metallo-beta-lactamase- producing Pseudomonas aeruginosa clinical isolates
    Yoshikazu Ishii
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku, Tokyo 143 8540, Japan
    Antimicrob Agents Chemother 54:3625-9. 2010
    ..The rates of susceptibility of MBL producers to carbapenems (imipenem, biapenem, and doripenem) and ceftazidime were increased by 8 to 27% in the presence of 32 microg/ml ..
  76. pmc Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2
    Hesna Yigit
    Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA
    Antimicrob Agents Chemother 47:3881-9. 2003
    ..pneumoniae 1534. Hydrolysis studies showed that purified KPC-2 hydrolyzed not only carbapenems but also penicillins, cephalosporins, and aztreonam. KPC-2 had the highest affinity for meropenem...
  77. pmc OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 49:202-8. 2005
    ..baumannii CIP7010(T) reference strain, it conferred reduced susceptibility to carbapenems. The bla(OXA-58) gene was bracketed by two novel ISAba3-like insertion elements...
  78. ncbi Resistance to carbapenems in sequence type 11 Klebsiella pneumoniae is related to DHA-1 and loss of OmpK35 and/or OmpK36
    So Youn Shin
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    J Med Microbiol 61:239-45. 2012
    ..pneumoniae infection. Sixteen K. pneumoniae isolates showing resistance to carbapenems collected from a tertiary-care hospital were examined for the mechanisms of carbapenem resistance...
  79. pmc Evaluation of PCR-based testing for surveillance of KPC-producing carbapenem-resistant members of the Enterobacteriaceae family
    Vered Schechner
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Clin Microbiol 47:3261-5. 2009
    ..blaKPC PCR-based testing is a useful method for the surveillance of KPC-producing CRE. Its main advantage over culturing is a shorter time to result, and it may prove to be more sensitive...
  80. ncbi Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens
    Yvonne Pfeifer
    Robert Koch Institute, Nosocomial Infections, Wernigerode Branch, Burgstr 37, 38855 Wernigerode, Germany
    Int J Med Microbiol 300:371-9. 2010
    ..Especially the increasing resistance to 3rd and 4th generation cephalosporins and carbapenems is of particular concern...
  81. ncbi A multicenter study of risk factors and outcome of hospitalized patients with infections due to carbapenem-resistant Acinetobacter baumannii
    Wang Huei Sheng
    Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei 100, Taiwan
    Int J Infect Dis 14:e764-9. 2010
    ..Risk factors and outcome in patients who acquire nosocomial infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) are rarely investigated...
  82. ncbi New Delhi Metallo-beta lactamase (NDM-1) in Enterobacteriaceae: treatment options with carbapenems compromised
    Payal Deshpande
    Dept of Research, P D Hinduja National Hospital and Medical Research Centre, Mumbai, India
    J Assoc Physicians India 58:147-9. 2010
    b>Carbapenems are among the few useful antibiotics against multidrug resistant gram negative bacteria particularly those with extended spectrum beta lactamase...
  83. ncbi Treatment of ESBL-producing Klebsiella pneumoniae bacteraemia with carbapenems or flomoxef: a retrospective study and laboratory analysis of the isolates
    Chen Hsiang Lee
    Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan
    J Antimicrob Chemother 58:1074-7. 2006
    ....
  84. pmc Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing
    Fred C Tenover
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Emerg Infect Dis 12:1209-13. 2006
    ..The recognition of carbapenem-resistant K. pneumoniae continues to challenge automated susceptibility systems...
  85. ncbi Carbapenemase-producing Klebsiella pneumoniae: (when) might we still consider treating with carbapenems?
    G L Daikos
    First Department of Propaedeutic Medicine, University of Athens, Athens, Greece
    Clin Microbiol Infect 17:1135-41. 2011
    ..Although CPKP isolates are often highly resistant to carbapenems, a proportion of these have relatively low MICs for carbapenems, raising the question of whether this class of ..
  86. ncbi Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin
    I K Neonakis
    Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Heraklion, Greece
    Chemotherapy 56:448-52. 2010
    ..Due to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens...
  87. pmc Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40
    Karen Lolans
    John Stroger Hospital, Chicago, IL 60612, USA
    Antimicrob Agents Chemother 50:2941-5. 2006
    ..This is the first time in the United States that such carbapenem resistance in A. baumannii has been attributable to a carbapenemase...
  88. pmc Endemic carbapenem-resistant Pseudomonas aeruginosa with acquired metallo-beta-lactamase determinants in European hospital
    Cristina Lagatolla
    Universita di Trieste, Trieste, Italy
    Emerg Infect Dis 10:535-8. 2004
    Acquired metallo-beta-lactamases (MBLs) can confer broad-spectrum beta-lactam resistance (including carbapenems) not reversible by conventional beta-lactamase inhibitors and are emerging resistance determinants of remarkable clinical ..
  89. pmc SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strains
    A M Queenan
    The R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
    Antimicrob Agents Chemother 44:3035-9. 2000
    ..isolates have been identified in the United States: 1 isolate in Minnesota in 1985 (before approval of carbapenems for clinical use), 5 isolates in Los Angeles (University of California at Los Angeles [UCLA]) in 1992, and 19 ..
  90. pmc Plasmid-mediated qnrB2 and carbapenemase gene bla(KPC-2) carried on the same plasmid in carbapenem-resistant ciprofloxacin-susceptible Enterobacter cloacae isolates
    Inna Chmelnitsky
    Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    Antimicrob Agents Chemother 52:2962-5. 2008
    ..One isolate also carried the aac(6')-Ib-cr gene. Coexistence of quinolone resistance determinants and bla(KPC-2) on the same plasmid in quinolone-susceptible E. cloacae isolates may have important clinical implications...
  91. ncbi Cluster of bloodstream infections caused by KPC-2 carbapenemase-producing Klebsiella pneumoniae in Manhattan
    Abhijeet S Nadkarni
    Harlem Hospital Center, New York, NY, USA
    Am J Infect Control 37:121-6. 2009
    b>Carbapenems are considered the agents of choice for treatment of serious infections caused by resistant gram-negative organisms...
  92. pmc Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of beta-barrel outer membrane proteins
    María A Mussi
    Instituto de Biologia Molecular y Celular de Rosario IBR, CONICET and Departamento de Microbiología, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
    Antimicrob Agents Chemother 49:1432-40. 2005
    ....
  93. pmc The combination of doripenem and colistin is bactericidal and synergistic against colistin-resistant, carbapenemase-producing Klebsiella pneumoniae
    Meredith G Jernigan
    Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 56:3395-8. 2012
    ..All other combinations were inferior. We are currently evaluating the combination of doripenem and colistin as a frontline therapy for KPC infection...
  94. ncbi The complex clinical picture of beta-lactam hypersensitivity: penicillins, cephalosporins, monobactams, carbapenems, and clavams
    Maria J Torres
    Allergy Service, Plaza del Hospital Civil, Pabellón 5 Sótano, Carlos Haya Hospital, Pabellon C, Malaga 29009, Spain
    Med Clin North Am 94:805-20, xii. 2010
    ..The natural history of IgE-mediated reactions indicates that the count of specific IgE antibodies decreases over time and that results of diagnostic tests can become negative...
  95. ncbi Clinical outcomes of carbapenem-resistant Acinetobacter baumannii bloodstream infections: study of a 2-state monoclonal outbreak
    L Silvia Munoz-Price
    University of Miami, Miami, FL, USA
    Infect Control Hosp Epidemiol 31:1057-62. 2010
    ..To characterize the clinical outcomes of patients with bloodstream infection caused by carbapenem-resistant Acinetobacter baumannii during a 2-state monoclonal outbreak...
  96. ncbi Carbapenem-resistant Acinetobacter baumannii infections after organ transplantation
    P Reddy
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Transpl Infect Dis 12:87-93. 2010
    ..acquisition of resistance to broad-spectrum beta-lactams, aminoglycosides, fluoroquinolones, and most notably, carbapenems. Despite a national rise in carbapenem-resistant A...
  97. ncbi Carbapenem resistance in Acinetobacter baumannii: the molecular epidemic features of an emerging problem in health care facilities
    Raffaele Zarrilli
    Department of Preventive Medical Sciences, Hygiene Section, University of Naples Federico II, Naples, Italy
    J Infect Dev Ctries 3:335-41. 2009
    ..b>Carbapenems have been widely used to treat serious multidrug-resistant A...
  98. ncbi Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, South Paris Medical School, University Paris XI, Le Kremlin Bicetre, France
    Clin Microbiol Infect 12:826-36. 2006
    ..baumannii may also result from porin or penicillin-binding protein modifications. Several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx of carbapenems, might be involved in carbapenem resistance.
  99. ncbi Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China
    Qiong Wu
    Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People s Republic of China
    Diagn Microbiol Infect Dis 66:326-8. 2010
    ..bla(KPC-2) was located on a large nonconjugative plasmid, whereas armA was located on another conjugative plasmid. Although carbapenem-resistant Enterobacteriaceae remains rare, the emergence of this group of organism merits monitoring...
  100. ncbi High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment
    Ryan K Shields
    University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Diagn Microbiol Infect Dis 70:246-52. 2011
    ..Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens...
  101. ncbi The new treatment paradigm and the role of carbapenems
    Robert G Masterton
    Ayrshire and Arran NHS Board, The Ayr Hospital, Ayrshire, UK
    Int J Antimicrob Agents 33:105-110. 2009
    ..resistance based on antibiotic de-escalation will be reviewed with particular emphasis on the role of the carbapenems. This approach attempts to balance the need to provide appropriate initial treatment whilst limiting the ..

Research Grants44

  1. Challenges in beta-Lactamase Mediated Resistance
    Robert A Bonomo; Fiscal Year: 2013
    ..and inhibition of PDC-3 [unreadable]-lactamase;a) To understand the interactions of PDC-3 with cephalosporins, carbapenems, and BATSIs on a deeper level, we will test the role of Thr105Ala, Thr289, Asn343, Asn346 and Arg349 in PDC-3 ..
  2. Preserving beta-lactam utility against pathogens producing all classes of beta-la
    LUIGI XERRI; Fiscal Year: 2012
    ..b-Lactam antibiotics, including penicillins, cephalosporins, monobactams and carbapenems, are the most widely used antibiotic class in the U.S...
  3. Analysis of metallo-beta-lactamase sequence constraints at high resolution
    Timothy Palzkill; Fiscal Year: 2013
    ..MBLs) catalyze the hydrolysis of a wide range of [unreadable]-lactam antibiotics including carbapenems and have emerged as an important source of resistance...
  4. Antibody Targeting of KPC and NDM1
    Brad J Spellberg; Fiscal Year: 2013
    ..are infections caused by extreme drug resistant (XDR) Gram negative bacilli (GNB), which are resistant to carbapenems and all other antibiotics except for colistin or tigecycline...
  5. 2012 New Antibacterial Drug Discovery and Development Gordon Research Conference
    Shahriar Mobashery; Fiscal Year: 2012
    ..to many of our best agents and, in the case of KPC [unreadable]-lactamases, this resistance profile includes carbapenems. In the case of Pseudomonas aeruginosa and Acinetobacter species, it is now reasonably common for an infecting ..
  6. Discovery of Polymyxin-based Antibacterial Agents Active Against Multi-Drug Resis
    Lawrence H Lash; Fiscal Year: 2013
    ..Gram-negative infections, colistin (polymyxin E) remains the only option of 'last resort', where the carbapenems are no longer active, and cases of tigecycline resistance have been reported...
  7. The molecular basis of epidemic blaKPC Klebsiella pneumoniae and Enterobacteriace
    BARRY NEAL KREISWIRTH; Fiscal Year: 2010
    ..The bacteria are commonly antibiotic resistant, but effectively treatable with carbapenems. However, over the last five years New York metropolitan area hospitals have experienced the emergence of ..
  8. Preserving beta-lactam utility vs pathogens producing any class of beta-lactamase
    LUIGI XERRI; Fiscal Year: 2013
    ..NDM-1 hydrolyzes all subclasses of [unreadable]-lactams (penicillins, cephalosporins and carbapenems) with the exception of monobactams (e.g., Aztreonam)...
  9. Molecular Archaeology: Vintage Beta Lactams for Resistant Gram Negative Infectio
    Marvin J Miller; Fiscal Year: 2013
    ..The carbapenems, while stable to most Class A and Class C beta-lactamases, are susceptible to Class B enzymes as well as ..
  10. Redesign of the Carbapenem Scaffold
    Bret M Benton; Fiscal Year: 2012
    ..provided by applicant): Carbapenemase-producing bacteria now threaten to undermine the efficacy of the carbapenems, long considered to be the most potent and reliable of the -lactam antibiotics...
  11. 2010 New Antimicrobial Drug Discovery and Development Gordon Research Conference
    GEORGE LOUIS DRUSANO; Fiscal Year: 2010
    ..them resistant to many of our best agents and, in the case of K-pc enzymes, this resistance profile includes carbapenems. In the case of Pseudomonas aeruginosa and Acinetobacter species, it is now reasonably common for an infecting ..
  12. A Mechanism-Based Approach to Metallo-beta-Lactamase Inhibition
    Alejandro J Vila; Fiscal Year: 2013
    ..We propose that a common anionic intermediate is formed in the hydrolysis of carbapenems by MBLs...
  13. BIOSYNTHESIS OF BETA-LACTAM ANTIBIOTICS
    CRAIG ARTHUR TOWNSEND; Fiscal Year: 2013
    ..the nocardicins, a family of monocyclic beta-lactams, and the metabolically related monobactams, and (3) the carbapenems, represented clinically by thienamycin and its derivatives, but most simply by carbapen-2-em-3-carboxylic acid...
  14. Pharmacokinetic-Pharmacodynamics of Antimicrobials in Resistant Infections
    Jennifer Le; Fiscal Year: 2013
    ..Vancomycin and carbapenems are the primary treatment strategy for serious infections caused by these MDR bacteria...
  15. Novel Metallo-beta-lactamase Inhibitors
    LUIGI XERRI; Fiscal Year: 2012
    ..e. penicillins, cephalosporins, carbapenems) both in hospital and community settings1,5,6...
  16. Development of Protein-Based Beta-lactam Antibiotic Resistance Diagnostics
    Timothy Palzkill; Fiscal Year: 2012
    ..exhibit broad substrate hydrolysis profiles which include penicillins, cephalosporins and, for a few enzymes, carbapenems. The class A TEM-1 and SHV-1 ?-lactamases are common plasmid-encoded ?-lactamases in gram-negative bacteria and ..
  17. Class D carbapenemases: defining the role of carbapenem conformational changes
    David A Leonard; Fiscal Year: 2012
    ..such as Acinetobacter baumannii, and they pose a serious threat to the use of the four clinically-approved carbapenems: imipenem, doripenem, meropenem and ertapenem...
  18. Mechanistic studies and inhibition strategies for antibiotic resistance
    Focco van den Akker; Fiscal Year: 2010
    ..those that hydrolyze cephalosporins are called extended-spectrum p-lactamases (ESBLs), and those that hydrolyze carbapenems are known as carbapenemases...
  19. Conformational Flexibility and Antibiotic Resistance
    Jeffrey W Peng; Fiscal Year: 2012
    ..The MRSA threat is especially insidious due to its resistance to 2-lactam antibiotics (e.g. penicillins, carbapenems, cephalosporins), which remain the most widely used anti-infectives in the clinic...
  20. The use of mass spectrometry for rapid detection of carbapenemase-producing bacte
    DAVID RYAN PEAPER; Fiscal Year: 2013
    ..substrate specificity, have evolved in response to treatment of infections with multiple b-lactam antibiotics Carbapenems represent the last line of effective defense against MDR GNRs expressing extended spectrum beta-lactamases (..
  21. Phase II SBIR: Responding to NDM-1 - Advancement of a new MBL inhibitor to IND
    LUIGI XERRI; Fiscal Year: 2013
    ..While carbapenems are among the most prescribed antibiotics for infections caused by these organisms, carbapenem resistance ..
  22. Evolution and inhibition of beta-lactamase activity in antibiotic resistance
    Yu Chen; Fiscal Year: 2013
    ..which include the widely used penicillins and cephalosporins, as well as last resort antibiotics such as the carbapenems. The development of novel [unreadable]-lactamase inhibitors is a pressing need underscored by the continuing ..
  23. Detecting Carbapenem and Quinolone Resistance in Klebsiella pneumoniae using PCR/
    Robert A Bonomo; Fiscal Year: 2010
    ..applicant): Among Gram-negative bacteria, nosocomial infections by Klebsiella pneumoniae that are resistant to carbapenems and quinolones are rapidly becoming a global problem...
  24. BIOSYNTHESIS OF BETA LACTAM ANTIBIOTICS
    Craig Townsend; Fiscal Year: 2003
    ..the nocardicins, a family of monocyclic beta-lactams, and the metabolically related monobactams, and (3) the carbapenems, represented clinically by thienamycin and its derivatives, but most simply by carbapen-2-em-3-carboxylic acid...
  25. Class A Carbapenemases
    Sergei Vakulenko; Fiscal Year: 2013
    ..of these clinically important enzymes and would provide an important guidance for the future utility of carbapenems, antibiotics of the last resort for treatment of life-threatening infections...
  26. BETA-LACTAM ANTIBIOTIC ALLERGY
    Timothy Sullivan; Fiscal Year: 1992
    IgE antibody mediated reactions to beta-lactam antibiotics (penicillins, cephalosporins, carbapenems, and monobactams) frequently complicate therapy with these agents and impose a serious limitation on their use...
  27. Mechanistic Studies of Carbapenem Synthase (CarC)
    COURTNEY JAMES HASTINGS; Fiscal Year: 2013
    ..While carbapenems are produced naturally, there are no fermentative or semisynthetic methods for the production of carbapenem ..
  28. Substrate Binding and Catalysis of Subclass B2 beta-Lactamases
    Hua Guo; Fiscal Year: 2007
    ..binding and catalysis of a subclass B2 [unreadable]-lactamase, which primarily catalyzes the hydrolysis of carbapenems with a single zinc cofactor...
  29. FLAGELLIN GLYCOSYLATION AND VIRULENCE OF P. AEROGINOSA
    Reuben Ramphal; Fiscal Year: 2005
    ..The existence of a central gene product involved in these could prove to be of great significance in controlling virulence. ..
  30. PSEUDOMONAS AERUGINOSA FLAGELLAR BIOGENESIS PATHWAY
    Reuben Ramphal; Fiscal Year: 2007
    ..abstract_text> ..
  31. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Type II secretion system of P. aeruginosa in acute lung infection
    Reuben Ramphal; Fiscal Year: 2010
    ..We wish to examine which of the many known toxins are involved in death and to explore new methods to block secretion of the toxins that may eventually be useful for therapy. ..
  33. Novel Targets for Treatment of Pseudomonas aeruginosa
    Philip Lister; Fiscal Year: 2008
    ..e. the carbapenems. The long-term goal is to identify new therapeutic targets to enhance treatment of multi-drug resistant P...
  34. Pharmacodynamics in Antifungal Resistance
    David Andes; Fiscal Year: 2005
    ..The candidate's goal is to integrate knowledge of antifungal PD and the acquisition of approaches and skills in molecular biology through the completion of this grant. ..
  35. STRUCTURE/FUNCTION OF AN ION MOTIVE ATPASE
    DOMENICO GATTI; Fiscal Year: 2001
    ..Analysis of the similarities and differences between these two enzymes will further our understanding of how ions are transported across biological membranes. ..
  36. MODELING THE UNDERSTANDING OF CHILDHOOD ASTHMA
    Adrian Casillas; Fiscal Year: 2002
    ..The candidate will have access to equipment, supplies, and technical support from the sponsor's laboratory. ..
  37. Structure, mechanism and evolution of KDO8P synthase
    DOMENICO GATTI; Fiscal Year: 2007
    ..abstract_text> ..
  38. Novel inhibitors of M. tuberculosis RNA Polymerase
    Anthony Lynch; Fiscal Year: 2003
    ..Phase II studies would thereafter be addressed toward systematic optimization of the series as an antitubercular agent. ..
  39. Legionella pneumophila developmental cycle & virulence
    PAUL STOKES HOFFMAN; Fiscal Year: 2011
    ..These studies should also provide insights relevant to other opportunistic environmental pathogens including oxiella, Burkholderia and species of Mycobacterium. ..
  40. Study of Mechanisms Leading to Multidrug-Resistant K. pneumoniae and A. baumannii
    John Quale; Fiscal Year: 2008
    ..Isolates resistant to all beta-lactams (including carbapenems), fluoroquinolones, and aminoglycosides have been documented...
  41. Prevention of Healthcare-Associated Drug-Resistant GNR
    Lisa Maragakis; Fiscal Year: 2006
    ..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
  42. Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB Infections
    Lisa Maragakis; Fiscal Year: 2009
    ..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
  43. Defining Moxifloxacin as a First-line TB Drug
    Eric Nuermberger; Fiscal Year: 2008
    ..Relevance: Results of these studies will help to define optimal treatment regimens for TB that can be used to design new clinical trials or, in some cases, directly applied to clinical practice. ..
  44. Hypocaloric Nutrition and Outcomes in Critically 111 Patients
    ROSEMARIE METZGER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..