beta lactams

Summary

Summary: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, and including monocyclic MONOBACTAMS. BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

Top Publications

  1. ncbi Penicillin-binding proteins and beta-lactam resistance
    André Zapun
    Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075 CNRS, CEA, Universite Joseph Fourier, Grenoble, France
    FEMS Microbiol Rev 32:361-85. 2008
  2. ncbi Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss
    Dolunay Gulmez
    Hacettepe University Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 06100 Sihhiye, Ankara, Turkey
    Int J Antimicrob Agents 31:523-6. 2008
  3. pmc Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene
    Thierry Naas
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicêtre 94275, and Faculté de Médecine Paris Sud, Paris, France
    Antimicrob Agents Chemother 52:1257-63. 2008
  4. ncbi Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    Jeffrey D Rothstein
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nature 433:73-7. 2005
  5. ncbi The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis
    Eric Sauvage
    Centre d Ingénierie des Protéines, Institut de Physique B5a et Institut de Chimie B6a, University of Liege, Sart Tilman, Belgium
    FEMS Microbiol Rev 32:234-58. 2008
  6. pmc Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals
    Laura Brinas
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, 26006 Logrono, Spain
    Antimicrob Agents Chemother 46:3156-63. 2002
  7. ncbi Emergence of CTX-M-type beta-lactam resistance in Shigella spp. in Hong Kong
    Terence Kin Man Cheung
    Int J Antimicrob Agents 25:350-2. 2005
  8. ncbi SOS response induction by beta-lactams and bacterial defense against antibiotic lethality
    Christine Miller
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Science 305:1629-31. 2004
  9. ncbi Prevalence and clonality of extended-spectrum beta-lactamases in Asia
    P M Hawkey
    Division of Immunity and Infection, University of Birmingham, Birmingham and Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heart of England NHS Trust, Bordesley Green East, Birmingham, UK
    Clin Microbiol Infect 14:159-65. 2008
  10. ncbi Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial
    Benjamin A Lipsky
    Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108 1597, USA
    Int Wound J 4:30-8. 2007

Detail Information

Publications214 found, 100 shown here

  1. ncbi Penicillin-binding proteins and beta-lactam resistance
    André Zapun
    Laboratoire d Ingénierie des Macromolécules, Institut de Biologie Structurale Jean Pierre Ebel, UMR 5075 CNRS, CEA, Universite Joseph Fourier, Grenoble, France
    FEMS Microbiol Rev 32:361-85. 2008
    ....
  2. ncbi Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss
    Dolunay Gulmez
    Hacettepe University Faculty of Medicine, Department of Microbiology and Clinical Microbiology, 06100 Sihhiye, Ankara, Turkey
    Int J Antimicrob Agents 31:523-6. 2008
    ..Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted...
  3. pmc Genetic structures at the origin of acquisition of the beta-lactamase bla KPC gene
    Thierry Naas
    Service de Bacteriologie Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Le Kremlin Bicêtre 94275, and Faculté de Médecine Paris Sud, Paris, France
    Antimicrob Agents Chemother 52:1257-63. 2008
    ..Tn4401 is likely at the origin of carbapenem-hydrolyzing beta-lactamase KPC mobilization to plasmids and its further insertion into various-sized plasmids identified in nonclonally related K. pneumoniae and P. aeruginosa isolates...
  4. ncbi Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
    Jeffrey D Rothstein
    Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Nature 433:73-7. 2005
    ..Thus these studies provide a class of potential neurotherapeutics that act to modulate the expression of glutamate neurotransmitter transporters via gene activation...
  5. ncbi The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis
    Eric Sauvage
    Centre d Ingénierie des Protéines, Institut de Physique B5a et Institut de Chimie B6a, University of Liege, Sart Tilman, Belgium
    FEMS Microbiol Rev 32:234-58. 2008
    ..An overview of the content in PBPs of some bacteria is provided with an emphasis on comparing the biochemical properties of homologous PBPs (orthologues) belonging to different bacteria...
  6. pmc Beta-lactamases in ampicillin-resistant Escherichia coli isolates from foods, humans, and healthy animals
    Laura Brinas
    Área de Bioquímica y Biología Molecular, Universidad de La Rioja, 26006 Logrono, Spain
    Antimicrob Agents Chemother 46:3156-63. 2002
    ..Different variants of bla(TEM-1) and IRT bla(TEM) genes were found among the AMP(r) E. coli isolates from foods and the feces of humans and healthy animals, and a new gene, bla(TEM-95b) (P3), was detected...
  7. ncbi Emergence of CTX-M-type beta-lactam resistance in Shigella spp. in Hong Kong
    Terence Kin Man Cheung
    Int J Antimicrob Agents 25:350-2. 2005
  8. ncbi SOS response induction by beta-lactams and bacterial defense against antibiotic lethality
    Christine Miller
    Department of Genetics, Stanford University, Stanford, CA 94305, USA
    Science 305:1629-31. 2004
    ....
  9. ncbi Prevalence and clonality of extended-spectrum beta-lactamases in Asia
    P M Hawkey
    Division of Immunity and Infection, University of Birmingham, Birmingham and Health Protection Agency, West Midlands Public Health Laboratory, Birmingham Heart of England NHS Trust, Bordesley Green East, Birmingham, UK
    Clin Microbiol Infect 14:159-65. 2008
    ..The high prevalence of ESBL genes in Asia means that the empirical treatment of serious infections with beta-lactam antibiotics, except carbapenems, is seriously compromised...
  10. ncbi Clinical predictors of treatment failure for diabetic foot infections: data from a prospective trial
    Benjamin A Lipsky
    Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108 1597, USA
    Int Wound J 4:30-8. 2007
    ..Increased white blood cell count and severe UT wound grade at baseline, but not other features, were significant independent and additive risk factors for clinical failure in patients treated for a diabetic foot infection...
  11. ncbi Differential effects of beta-lactams on human IFN-gamma activity
    Bernadette M Brooks
    Department of Pharmacology and Therapeutics, University of Liverpool, Ashton Street, Liverpool L69 3GE, UK
    J Antimicrob Chemother 56:1122-5. 2005
    ....
  12. ncbi Pharmacokinetics and pharmacodynamics of ertapenem: an overview for clinicians
    David E Nix
    University of Arizona College of Pharmacy, Tucson, AZ, USA
    J Antimicrob Chemother 53:ii23-8. 2004
    ..Ertapenem is neither a substrate nor an inhibitor of P-glycoprotein or cytochrome P450 enzymes; significant drug interactions between ertapenem and drugs handled by these systems are not expected...
  13. pmc Combinations of vancomycin and beta-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin
    M W Climo
    Department of Medicine, Medical College of Virginia Campus of Virginia Commonwealth University, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, USA
    Antimicrob Agents Chemother 43:1747-53. 1999
    ....
  14. ncbi Effect of D240G substitution in a novel ESBL CTX-M-27
    R Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, Service de Bacteriologie Virologie, 28 Place Henri Dunant, 63001 Clermont Ferrand cedex, France
    J Antimicrob Chemother 52:29-35. 2003
    ....
  15. pmc Occurrence of extended-spectrum beta-lactamases in members of the genus Shigella in the Republic of Korea
    Seonghan Kim
    Laboratory of Enteric Infections, Department of Microbiology, National Institute of Health Korea, Eunpyeong gu, Seoul, Republic of Korea 122 701
    J Clin Microbiol 42:5264-9. 2004
    ..This is the first report of the presence of TEM-17, TEM-19, and TEM-20 in Korea and in S. sonnei...
  16. ncbi Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy
    Thomas P Lodise
    Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208, USA
    Clin Infect Dis 44:357-63. 2007
    ..This study evaluates the clinical implications of extended infusion of piperacillin-tazobactam therapy for critically ill patients with P. aeruginosa infection...
  17. ncbi A study evaluating the efficacy, safety, and tolerability of ertapenem versus ceftriaxone for the treatment of community-acquired pneumonia in adults
    Guillermo Ortiz-Ruiz
    Hospital Santa Clara, Bogota, Colombia
    Clin Infect Dis 34:1076-83. 2002
    ..8% versus 2.0%) in the ertapenem and ceftriaxone groups, respectively. These results suggest that ertapenem and ceftriaxone therapy have similar efficacy and safety in hospitalized patients with community-acquired pneumonia...
  18. pmc Ertapenem once a day versus piperacillin-tazobactam every 6 hours for treatment of acute pelvic infections: a prospective, multicenter, randomized, double-blind study
    Subir Roy
    Keck School of Medicine at USC, Los Angeles, CA, USA
    Infect Dis Obstet Gynecol 11:27-37. 2003
    ..To compare ertapenem therapy with piperacillin-tazobactam therapy for the management of acute pelvic infections...
  19. pmc Ertapenem versus ceftriaxone followed by appropriate oral therapy for treatment of complicated urinary tract infections in adults: results of a prospective, randomized, double-blind multicenter study
    Kevin M Tomera
    Alaska Clinical Research Center, Anchorage, Alaska, USA
    Antimicrob Agents Chemother 46:2895-900. 2002
    ..In this study, ertapenem was as effective as ceftriaxone for the initial treatment of complicated UTIs in adults, was generally well tolerated, and had a similar overall safety profile...
  20. ncbi Pharmacodynamic target attainment of six beta-lactams and two fluoroquinolones against Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella species collected from United States intensive care units in 2004
    C Andrew DeRyke
    Center for Anti Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA
    Pharmacotherapy 27:333-42. 2007
    ..To determine the likelihood that antibiotic regimens achieve bactericidal pharmacodynamic exposures against common nosocomial pathogens...
  21. pmc Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a
    Sandrine Lemaire
    Unité de Pharmacologie Cellulaire et Moléculaire, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Biol Chem 283:12769-76. 2008
    ....
  22. ncbi Arrival of Klebsiella pneumoniae producing KPC carbapenemase in the United Kingdom
    Neil Woodford
    Centre for Infections, Health Protection Agency, 61 Colindale Avenue, London NW9 5EQ, UK
    J Antimicrob Chemother 62:1261-4. 2008
    ..KPC-type carbapenemases are increasingly prevalent in parts of the USA and Israel and are an emerging concern in South America, Europe and China. We investigated the UK's first two KPC-producing Klebsiella pneumoniae isolates...
  23. pmc Interaction of zwitterionic penicillins with the OmpF channel facilitates their translocation
    Christophe Danelon
    Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    Biophys J 90:1617-27. 2006
    ..These observations confirm our earlier suggestion that a set of high-affinity sites at the narrowest part of the OmpF channel improves a drug's ability to cross the membrane via the pore...
  24. ncbi Redefining penems
    Axel Dalhoff
    University Hospital Schleswig Holstein, Campus Kiel, Institute for Infection Medicine, Brunswiker Str 4, D 24105 Kiel, Germany
    Biochem Pharmacol 71:1085-95. 2006
    ....
  25. ncbi Ertapenem versus piperacillin/tazobactam for diabetic foot infections (SIDESTEP): prospective, randomised, controlled, double-blinded, multicentre trial
    Benjamin A Lipsky
    University of Washington School of Medicine and Veterans Affairs Puget Sound Health Care System S 111 GIMC, 1660 S Columbian Way, Seattle, WA 98108, USA
    Lancet 366:1695-703. 2005
    ..Our aim was to assess the efficacy and safety of ertapenem versus piperacillin/tazobactam for foot infections...
  26. ncbi Compartmentalization and transport in beta-lactam antibiotics biosynthesis
    M E Evers
    University of Groningen, Department of Molecular Microbiology and Groningen Biomolecular Sciences and Biotechnology Institute, Kerklaan 30, 9751 NN Haren, The Netherlands
    Adv Biochem Eng Biotechnol 88:111-35. 2004
    ..This compartmentalization also requires specific membrane transport steps of which the details are currently uncovered...
  27. ncbi Efficacy and safety of ertapenem versus piperacillin-tazobactam for the treatment of intra-abdominal infections requiring surgical intervention
    Arturo S Dela Pena
    Philippine General Hospital, Manila, Philippines
    J Gastrointest Surg 10:567-74. 2006
    ..In this study, ertapenem and piperacillin/tazobactam were comparably safe and effective treatments for adult patients with complicated intra-abdominal infections...
  28. pmc Identification of CTX-M-14 extended-spectrum beta-lactamase in clinical isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea
    H Pai
    Department of Internal Medicine, Dankook University College of Medicine, Chonan, Korea
    J Clin Microbiol 39:3747-9. 2001
    ..The amino acid sequence differed by one amino acid from CTX-M-9 (Ala-231--> Val) and was identical to that of beta-lactamases recently found in China and Japan...
  29. ncbi Randomized, multicenter, double-blind study of efficacy, safety, and tolerability of intravenous ertapenem versus piperacillin/tazobactam in treatment of complicated intra-abdominal infections in hospitalized adults
    Nicholas Namias
    Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Surg Infect (Larchmt) 8:15-28. 2007
    ..Complicated intra-abdominal infections are a common problem in surgical practice. This study compared the effectiveness of ertapenem (1 g qd) and piperacillin/tazobactam (3.375 g q6h) in the treatment of these infections...
  30. ncbi Diffusion of ertapenem into bone and synovial tissues
    E Boselli
    Department of Anaesthesiology and Intensive Care, Edouard Herriot, Lyon, France
    J Antimicrob Chemother 60:893-6. 2007
    ..However, no studies concerning its diffusion into bone and synovial tissue are available. Our objective was to quantify ertapenem bone and synovial tissue penetration and to compare our data with the MIC(90)s for causative pathogens...
  31. ncbi Penetration of ertapenem into skeletal muscle and subcutaneous adipose tissue in healthy volunteers measured by in vivo microdialysis
    Olaf Burkhardt
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    J Antimicrob Chemother 58:632-6. 2006
    ..Microdialysis and plasma samples were collected before and at different time points up to 12 h after medication. Drug concentrations were determined by a validated LC-MS-MS method...
  32. pmc Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France
    Stephanie Petrella
    UPMC Univ Paris 06, EA1541, Bactériologie Hygiène, Paris, France
    Antimicrob Agents Chemother 52:3725-36. 2008
    ....
  33. pmc Tissue penetration by ertapenem, a parenteral carbapenem administered once daily, in suction-induced skin blister fluid in healthy young volunteers
    T Laethem
    Merck and Co, Inc, Brussels, Belgium
    Antimicrob Agents Chemother 47:1439-42. 2003
    ..The area under the concentration-time curve for 0 to 24 h ratio of blister fluid to plasma was 61% (90% confidence interval, 56, 65%) suggesting good blister penetration...
  34. ncbi Comparative costs of ertapenem and piperacillin-tazobactam in the treatment of diabetic foot infections
    Alan D Tice
    John A Burns School of Medicine, University of Hawaii, Honolulu, USA
    Am J Health Syst Pharm 64:1080-6. 2007
    ..To evaluate potential cost savings, trial data were used to determine the clinical outcomes for i.v. ertapenem given once daily and i.v. piperacillin-tazobactam given every six hours daily in treating diabetic foot infections...
  35. ncbi Properties and potential of ertapenem
    David M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT
    J Antimicrob Chemother 52:331-44. 2003
    ..Nevertheless, if ertapenem is to be used widely, its effects on the resistance ecology need to be monitored carefully...
  36. ncbi The implications of enterococci for the intensive care unit
    Indranil Chatterjee
    Department of Intensive Care Medicine, Royal Brisbane and Women s Hospital, Brisbane, QLD, Australia
    Crit Care Resusc 9:69-75. 2007
    ..To review the evidence of pathogenicity and virulence of Enterococcus spp. in the intensive care unit...
  37. pmc Ertapenem versus piperacillin/tazobactam in the treatment of complicated intraabdominal infections: results of a double-blind, randomized comparative phase III trial
    Joseph S Solomkin
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0558, USA
    Ann Surg 237:235-45. 2003
    ..To examine the clinical efficacy and safety of ertapenem, a novel beta-lactam agent with wide activity against common pathogens encountered in intraabdominal infection...
  38. ncbi Bowel colonization with resistant gram-negative bacilli after antimicrobial therapy of intra-abdominal infections: observations from two randomized comparative clinical trials of ertapenem therapy
    M J DiNubile
    Merck and Co, Whitehouse Station, NJ, USA
    Eur J Clin Microbiol Infect Dis 24:443-9. 2005
    ....
  39. pmc Acquisition of resistant bowel flora during a double-blind randomized clinical trial of ertapenem versus piperacillin-tazobactam therapy for intraabdominal infections
    Mark J DiNubile
    Merck Research Laboratories, P O Box 4, BL3 4, West Point, PA 19486, USA
    Antimicrob Agents Chemother 49:3217-21. 2005
    ..6%; P = 0.10). In this study, the acquisition of resistant Enterobacteriaceae occurred significantly more often in patients treated with piperacillin-tazobactam than in those treated with ertapenem...
  40. pmc Extended-spectrum beta-lactamases: a clinical update
    David L Paterson
    Infectious Disease Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Microbiol Rev 18:657-86. 2005
    ..ESBLs represent an impressive example of the ability of gram-negative bacteria to develop new antibiotic resistance mechanisms in the face of the introduction of new antimicrobial agents...
  41. ncbi Ertapenem once daily versus piperacillin-tazobactam 4 times per day for treatment of complicated skin and skin-structure infections in adults: results of a prospective, randomized, double-blind multicenter study
    Donald R Graham
    Springfield Clinic, Springfield, IL, 62703, USA
    Clin Infect Dis 34:1460-8. 2002
    ..Cure rates for the 2 treatment groups were similar when compared by stratum, diagnosis, and severity of infection. The frequency and severity of drug-related adverse events were similar in the treatment groups...
  42. pmc Role of beta-lactamases and porins in resistance to ertapenem and other beta-lactams in Klebsiella pneumoniae
    George A Jacoby
    Lahey Clinic, Burlington, Mssachusetts 01805, USA
    Antimicrob Agents Chemother 48:3203-6. 2004
    ..From a wild-type strain producing ACT-1 beta-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 microg/ml and expression of outer membrane proteins was diminished could be selected...
  43. ncbi The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus
    Cosimo Fuda
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA
    J Biol Chem 279:40802-6. 2004
    ..The observed conformational changes are likely to be a hallmark for how this enzyme carries out its catalytic function in cross-linking the bacterial cell wall...
  44. ncbi Treatment of polymicrobial infections: post hoc analysis of three trials comparing ertapenem and piperacillin-tazobactam
    Joseph Solomkin
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Antimicrob Chemother 53:ii51-7. 2004
    ..9% and 91.5% for pelvic infections. These data show that in the three trials, ertapenem 1 g once a day was highly effective for the treatment of polymicrobial infections and as effective as piperacillin-tazobactam 3.375 g every 6 h...
  45. ncbi Ertapenem: review of a new carbapenem
    George G Zhanel
    Health Sciences Center, Clinical Microbiology, MS673 820, Sherbrook Street, Winnipeg, Manitoba, R3A 1R9, Canada
    Expert Rev Anti Infect Ther 3:23-39. 2005
    ..Ertapenem is a promising new carbapenem with excellent efficacy and safety for the treatment of a variety of community-acquired infections. It also appears to be of great value as an outpatient parenteral antimicrobial therapy...
  46. pmc Bactericidal activities of meropenem and ertapenem against extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a neutropenic mouse thigh model
    C Andrew DeRyke
    Center for Anti Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA, and Department of Infectious Disease, Peking Union Medical College Hospital, Beijing, China
    Antimicrob Agents Chemother 51:1481-6. 2007
    ..However, for isolates with raised ertapenem MICs of>or=2 microg/ml, meropenem displayed sustained efficacy due to its greater in vitro potency and higher resultant fT>MIC...
  47. ncbi Spread of novel expanded-spectrum beta-lactamases in Enterobacteriaceae in a university hospital in the Paris area, France
    M F Lartigue
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, K Bicêtre, France
    Clin Microbiol Infect 11:588-91. 2005
    ..coli, two Enterobacter cloacae, one Enterobacter aerogenes, one Proteus mirabilis and one Citrobacter freundii). Other ESBLs, such as VEB-1 and PER-1, were also detected, but less frequently...
  48. ncbi Ertapenem: a Group 1 carbapenem with distinct antibacterial and pharmacological properties
    Milton L Hammond
    Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA
    J Antimicrob Chemother 53:ii7-9. 2004
    ..As a result, ertapenem is highly protein bound and has an extended half-life, permitting a once-a-day treatment regimen...
  49. ncbi Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States
    Keiko Hasegawa
    Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, 108 8641, Japan
    Microb Drug Resist 9:39-46. 2003
    ..Differences in proportions of respective AMP-resistant genes in H. influenzae isolates between the two countries might reflect differences in antibiotic agents ordinarily given to outpatients with community-acquired bacterial infections...
  50. ncbi In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase
    Eugenne Elliott
    Department of Clinical Microbiology, Ampath Laboratories, Milpark Hospital, Johannesburg, South Africa
    Clin Infect Dis 42:e95-8. 2006
    ..All 4 isolates belonged to the same strain and produced a group 1 CTX-M enzyme; additionally, the resistant isolates had lost a porin...
  51. ncbi Experiences with an identification and quantification program for inhibitor-positive milk samples
    Claudia Kress
    Dairy Sciences, Institute of Veterinary Food Science, Justus Liebig University, Ludwigstr 21, 35390 Giessen, Germany
    Anal Chim Acta 586:275-9. 2007
    ..3%), isoxazolyl penicillins (3.2%), and sulfonamides (1.6%). The results indicate that penicillin G is still the predominant antibiotic responsible for violative bulk tank milk samples as detected during regulatory control...
  52. ncbi Development of a receptor-based microplate assay for the detection of beta-lactam antibiotics in different food matrices
    Janine Lamar
    Department of Food Chemistry, University of Wuppertal, Gauss Strasse 20, 42119 Wuppertal, Germany
    Anal Chim Acta 586:296-303. 2007
    ..Matrix calibration curves are presented, which show that quantitative analyses are possible...
  53. ncbi Meta-analysis: ertapenem for complicated intra-abdominal infections
    M E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Aliment Pharmacol Ther 27:919-31. 2008
    ..Ertapenem is a new member of the carbapenem class of antibiotics, with a favourable pharmacokinetic profile, but a narrower spectrum of antimicrobial activity, compared with older representatives of this class...
  54. pmc Bifunctional asymmetric catalysis: cooperative Lewis acid/base systems
    Daniel H Paull
    Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA
    Acc Chem Res 41:655-63. 2008
    ..To place our results in perspective, many important contributions to this emerging field are highlighted and our own reports are chronicled...
  55. ncbi Carbapenem-hydrolysing beta-lactamase KPC-2 in Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil
    Gisele Peirano
    Oswaldo Cruz Institute, Avenida Brasil 4365, 21040 360 Rio de Janeiro, Brazil
    J Antimicrob Chemother 63:265-8. 2009
    ..The aim of this study was to characterize the KPC-type carbapenem-hydrolysing beta-lactamase, extended-spectrum beta-lactamases (ESBLs) and class 1 integrons among nosocomial Klebsiella pneumoniae isolated in Rio de Janeiro, Brazil...
  56. ncbi In vitro susceptibility of recent antibiotic-resistant urinary pathogens to ertapenem and 12 other antibiotics
    A Alhambra
    Department of Microbiology, Hospital de Mostoles, 28935 Móstoles, Madrid, Spain
    J Antimicrob Chemother 53:1090-4. 2004
    ..Ertapenem is a broad-spectrum 1beta-methyl carbapenem with a long plasma half-life that allows administration of a single daily dose...
  57. ncbi NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum beta-lactamases and carbapenemases
    David M Livermore
    Health Protection Agency Centre for Infections, London, UK
    J Antimicrob Chemother 62:1053-6. 2008
    ..We examined whether combinations of oxyimino-cephalosporins with NXL104, a novel non-beta-lactam beta-lactamase inhibitor, overcame these resistances...
  58. ncbi Neisseria gonorrhoeae penicillin-binding protein 3 exhibits exceptionally high carboxypeptidase and beta-lactam binding activities
    Miglena E Stefanova
    Division of Pharmaceutical Sciences, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    Biochemistry 42:14614-25. 2003
    ..gonorrhoeae, although deletion of both PBP 3 and PBP 4, the other low-molecular-mass PBP in N. gonorrhoeae, resulted in a decreased growth rate and marked morphological abnormalities...
  59. ncbi Evaluation of in vitro interaction of daptomycin with gentamicin or beta-lactam antibiotics against Staphylococcus aureus and Enterococci by FIC index and timed-kill curves
    D R Snydman
    Tufts New England Medical Center, 750 Washington St, Boston, MA 02111, USA
    J Chemother 17:614-21. 2005
    ..A bactericidal effect was exerted in 5/7 synergistic combinations. The in vitro data suggest that daptomycin combined with other antibiotics may be microbiologically beneficial and not antagonistic...
  60. ncbi Comparative in vitro activity and the inoculum effect of ertapenem against Enterobacteriaceae resistant to extended-spectrum cephalosporins
    Carmen Betriu
    Department of Clinical Microbiology, Hospital Clinico San Carlos, Plaza Cristo Rey s n, 28040 Madrid, Spain
    Int J Antimicrob Agents 28:1-5. 2006
    ..The data from this study suggest that this new carbapenem may be useful for treating mixed infections involving Enterobacteriaceae isolates resistant to third-generation cephalosporins...
  61. ncbi Reevaluation of Enterobacteriaceae MIC/disk diffusion zone diameter regression scattergrams for 9 beta-lactams: adjustments of breakpoints for strains producing extended spectrum beta-lactamases
    Ronald N Jones
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 52:235-46. 2005
    ....
  62. ncbi Beta-lactam screening by specific residues of the OmpF eyelet
    Stephanie Vidal
    GERCTOP UMR6178 CNRS, IFR48, Faculte de Pharmacie, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    J Med Chem 48:1395-400. 2005
    ..Molecular modeling suggests that the charges harbored by the beta-lactam molecules interact with the charged residues located inside the porin eyelet...
  63. ncbi Phenotypic confirmation of extended-spectrum B-lactamases (ESBL) in clinical isolates of Escherichia coli and Klebsiella pneumoniae at the San Juan Veterans Affairs Medical Center
    Maria del Carmen Rodríguez
    Infectious Diseases Research Laboratory, San Juan Veterans Affairs Medical Center, Puerto Rico 00921 3201
    P R Health Sci J 23:207-15. 2004
    ..Inappropriate antibiotic selection in infections caused by these organisms is associated with treatment failures, poor clinical outcomes, increased mortality and longer hospital stays...
  64. ncbi Pharmacodynamic modeling of carbapenems and fluoroquinolones against bacteria that produce extended-spectrum beta-lactamases
    Leticia R Moczygemba
    College of Pharmacy, The University of Texas at Austin, USA
    Clin Ther 26:1800-7. 2004
    ....
  65. ncbi Emerging epidemic of metallo-beta-lactamase-mediated resistances
    Ronald N Jones
    Diagn Microbiol Infect Dis 51:77-84. 2005
  66. ncbi Real-time TaqMan PCR for rapid detection and typing of genes encoding CTX-M extended-spectrum beta-lactamases
    Christopher I Birkett
    Health Protection Agency, Clinical Microbiology and Public Health Laboratory, Addenbrooke s Hospital, Cambridge, UK
    J Med Microbiol 56:52-5. 2007
    ..The new TaqMan assay detected and typed bla(CTX-M) genes in 21 of 28 ESBL-producing isolates...
  67. ncbi IMP-1 metallo-beta-lactamase-producing Pseudomonas aeruginosa in a university hospital in the People's Republic of China
    Chun Xin Wang
    J Antimicrob Chemother 54:1159-60. 2004
  68. ncbi Activity of ertapenem and other antimicrobials against ESBL-producing enterobacteria isolated from urine in patients from Madrid
    J Tamayo
    Servicio de Microbiologia, Hospital de Mostoles, Madrid, Espana
    Rev Esp Quimioter 20:334-8. 2007
    ....
  69. pmc Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams
    A Mazzariol
    Institute of Microbiology, University of Verona, Verona, Italy
    Antimicrob Agents Chemother 44:1387-90. 2000
    ..MICs of ureidopenicillins, carbenicillin, oxacillin, and cloxacillin were drastically reduced by the inactivation of AcrAB, whereas those of the earlier cephalosporins were affected mostly by the loss of AmpC beta-lactamase...
  70. ncbi Cefepime and the inoculum effect in tests with Klebsiella pneumoniae producing plasmid-mediated AmpC-type beta-lactamase
    Cheol In Kang
    Departments of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Republic of Korea
    J Antimicrob Chemother 54:1130-3. 2004
    ..This study was conducted to investigate the activity of cefepime against clinical isolates by determining the activities of cefepime and three other parenteral beta-lactam agents in standard and high inoculum MIC tests...
  71. ncbi Salicylate decreases production of AmpC type beta-lactamases and increases susceptibility to beta-lactams in a Morganella morganii clinical isolate
    María M Tavío
    Microbiology, Department of Clinical Sciences II, Health Sciences Building, University of Las Palmas de G C, Dr Pasteur, 35080 Las Palmas de, G C Spain
    FEMS Microbiol Lett 238:139-44. 2004
    ..Likewise, salicylate only repressed 46 kDa outer membrane protein expression in the wild-type strain, since the clinical isolate M1 did not express it...
  72. ncbi Patterns of resistance to beta-lactams and characterization of beta-lactamases in Escherichia coli isolates from children in Tunisia
    S Rejiba
    Department des Sciences Biologiques, Faculte des Sciences de Tunis, Tunisia
    J Chemother 19:382-7. 2007
    ..bla(SHV) genes were detected in three isolates producing pI 7.9 ESBLs but not in two isolates expressing pI 8.7 ESBLs. These latter showed strong cefotaxime-hydrolyzing activities. Hence, they might be CTX-M-type ESBLs...
  73. ncbi Evaluation of genetic determinants involved in beta-lactam- and multiresistance in a surgical ICU
    H J van Loon
    Eijkman Winkler Institute for Microbiology, Infectious Disease and Inflammation, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Antimicrob Agents 24:130-4. 2004
    ..It can be concluded that integrons and associated resistance determinants played only a minor role in the surgical ICU and beta-lactam resistance among P. aeruginosa isolates was most likely due to the derepression of its AmpC gene...
  74. ncbi Antimicrobial treatment of Capnocytophaga infections
    Anne Jolivet-Gougeon
    Equipe Microbiologie, UPRES EA 1254, CHU Pontchaillou Rennes et Université de Rennes I, 2 Avenue du Professeur Leon Bernard, 35043 Rennes Cedex, France
    Int J Antimicrob Agents 29:367-73. 2007
    ..Imipenem/cilastatin, clindamycin or beta-lactamase inhibitor combinations are always effective and their use can be recommended in all infections...
  75. pmc Countrywide spread of community- and hospital-acquired extended-spectrum beta-lactamase (CTX-M-15)-producing Enterobacteriaceae in Lebanon
    Carole Moubareck
    Laboratoire de Microbiologie, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris 5 Rene Descartes, Paris, France
    J Clin Microbiol 43:3309-13. 2005
    ..In addition to the fact that the present study highlights the emergence and the countrywide dissemination of CTX-M-15-producing E. coli in Lebanon, it represents the first report of an SHV-5a-producing C. freundii...
  76. ncbi Defining an extended-spectrum beta-lactamase
    D M Livermore
    Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency Centre for Infections, London, UK
    Clin Microbiol Infect 14:3-10. 2008
    ..It seems best-and pragmatic-that the term 'ESBL' retains its broad modern usage, but that should always be accompanied by mention of the enzyme's family as, e.g., in 'TEM ESBL' or 'OXA ESBL', not as a sole moniker...
  77. ncbi [Conjugative transfer frequency of resistance genes from ESBL-producing Enterobacteriaceae strains isolated from patients hospitalized in pediatric wards]
    Roman Franiczek
    Katedra i Zakład Mikrobiologii Akademii Medycznej we Wrocławiu
    Med Dosw Mikrobiol 58:41-51. 2006
    ..Genetic markers conferring resistance to aminoglycosides and cotrimoxazole were often co-transferred to recipient strain in conjugation process...
  78. ncbi Prevalence and characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated in Korean hospitals
    Kwan Soo Ko
    Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 440 746, Korea
    Diagn Microbiol Infect Dis 61:453-9. 2008
    ..3%). These significant differences in ESBL-producing K. pneumoniae and E. coli isolates among the isolated specimens should be examined further, with an eye toward the implications of this research in clinical settings...
  79. ncbi Characterization of TEM-, SHV- and AmpC-type beta-lactamases from cephalosporin-resistant Enterobacteriaceae isolated from swine
    Nabin Rayamajhi
    Department of Infectious Diseases, College of Veterinary Medicine, KRF Zoonotic Disease Priority Research Institute, Brain Korea 21 for Veterinary Science, Seoul National University, San 56 1, Shilim 9 dong, Kwanak Ku, Seoul, Republic of Korea
    Int J Food Microbiol 124:183-7. 2008
    ..To the best of our knowledge, this study reports the first identification of SHV-28 and DHA-1 from microbes of animal origin...
  80. ncbi Appearance of aac(6')-Ib-cr gene among extended-spectrum beta-lactamase-producing Enterobacteriaceae in a French hospital
    V Fihman
    Service de Bacteriologie Virologie, Hopital Lariboisiere, Assistance Publique Hopitaux de Paris, Universite Paris VII, 2, rue Ambroise Pare, 75475 Paris, France
    J Infect 56:454-9. 2008
    ..The aim of our study was to observe the appearance and the location of the aac(6')-Ib gene in extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae strains...
  81. ncbi Extended-spectrum beta-lactamase-conferring transferable resistance to different antimicrobial agents in Enterobacteriaceae isolated from bloodstream infections
    R Franiczek
    Department of Microbiology, University of Medicine in Wrocław, 50 368 Wrocław, Poland
    Folia Microbiol (Praha) 50:119-24. 2005
    ..Resistances to aminoglycosides, tetracycline and mercuric chloride were, in some cases, co-transferred with oxyimino-beta-lactam resistance, suggesting that various resistance determinants were carried by the same conjugative plasmids...
  82. ncbi Characterization of imipenem-resistant Serratia marcescens producing IMP-type and TEM-type beta-lactamases encoded on a single plasmid
    Wei Hua Zhao
    Department of Medical Biology, Showa University School of Medicine, Tokyo, Japan
    Microbiol Res 162:46-52. 2007
    ..These findings may explain the rapid spread of the above resistance determinants among Enterobacteriaceae via transmissible plasmids in the clinical setting...
  83. ncbi Comparison of antimicrobial resistance of Acinetobacter baumannii clinical isolates from Shanghai and Hong Kong
    Thomas K W Ling
    Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China
    Med Princ Pract 14:338-41. 2005
    ..To compare the antimicrobial resistance patterns of Acinetobacter baumannii isolates from Shanghai and Hong Kong...
  84. ncbi A plasmid-mediated CMY-2 beta-lactamase from an Algerian clinical isolate of Salmonella senftenberg
    J L Koeck
    Laboratoire de Biologie Medicale, Hopital d Instruction des armees BEGIN, Saint Mande, France
    FEMS Microbiol Lett 152:255-60. 1997
    ..It showed 99.5% sequence identity with the plasmid-mediated beta-lactamase CMY-2. The differences in the amino acid sequences of the two enzymes were located in the signal peptide...
  85. pmc Survey of Enterobacteriaceae producing extended-spectrum beta-lactamases in a Slovak hospital: dominance of SHV-2a and characterization of TEM-132
    Martina Zarnayová
    Laboratoire de Bacteriologie, Hopital Universitaire du Bocage, BP 77908, 21079 Dijon Cedex, France
    Antimicrob Agents Chemother 49:3066-9. 2005
    ....
  86. ncbi Longitudinal European surveillance study of antibiotic resistance of Haemophilus influenzae
    W T M Jansen
    Eijkman Winkler Center for Medical Microbiology and Infectious Diseases, University Medical Center Utrecht G 04 614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Antimicrob Chemother 58:873-7. 2006
    ..We assessed the current resistance rates of Haemophilus influenzae against beta-lactams and other agents in Europe and compared the results with those of our previously performed surveillance study...
  87. pmc Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
    Antimicrob Agents Chemother 52:2014-8. 2008
    ..coli isolates emerged in ICUs in our hospital. KPC-2 combined with porin deficiency results in high-level carbapenem resistance in K. pneumoniae. The same bla(KPC-2)-encoding plasmid was spread among the three different genera...
  88. ncbi Comparative in vitro activity of ertapenem against extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolated in Spain
    Jose R Hernandez
    Department of Microbiology, Faculty of Medicine, University of Seville, Av Sánchez Pizjuán S N, 41009 Seville, Spain
    Int J Antimicrob Agents 28:457-9. 2006
    ..Ertapenem activity was similar to that of imipenem and meropenem and better than that of the other antimicrobials tested. No differences in activity were observed regarding the origin of the isolates or type of ESBL produced...
  89. ncbi [Estimation of the contribution of the small plasmids in creation of ESBL phenotype among clinical and ambulatory isolates of the Enterobacteriaceae]
    Jozef Nieradko
    Katedra Mikrobiologii Uniwersytetu Gdańskiego w Gdańsku
    Med Dosw Mikrobiol 59:223-30. 2007
    ..The similarity of plazmid profiles isolated from E. coli and Klebsiella pneumoniae and K. oxytoca suggests possibility of the exchange of these plazmids between two mentioned species of bacteria...
  90. pmc Molecular epidemiology of the integron-located VEB-1 extended-spectrum beta-lactamase in nosocomial enterobacterial isolates in Bangkok, Thailand
    D Girlich
    , , , , , France
    J Clin Microbiol 39:175-82. 2001
    ..Plasmid- and integron-mediated resistance to rifampin was also found in enterobacterial isolates...
  91. pmc Evaluation of the Osiris expert system for identification of beta-lactam phenotypes in isolates of Pseudomonas aeruginosa
    Frederic Bert
    Service de Microbiologie, Hopital Beaujon, 92110 Clichy, France
    J Clin Microbiol 41:3712-8. 2003
    ..aeruginosa beta-lactam phenotypes. A specific double-disk synergy test with reduced disk distances is necessary for the detection of ESBL production by this organism...
  92. pmc In vitro activities of novel oxapenems, alone and in combination with ceftazidime, against gram-positive and gram-negative organisms
    Conor E Jamieson
    Life and Health Sciences, Aston University, Birmingham, United Kingdom
    Antimicrob Agents Chemother 47:2615-8. 2003
    ..There was little difference between the activity of 1:1 and 2:1 combinations of ceftazidime and oxapenem. The oxapenems failed to enhance the activity of ceftazidime against derepressed AmpC-producing Pseudomonas aeruginosa strains...
  93. ncbi Metallo-beta-lactamase VIM-2 in clinical isolates of Pseudomonas aeruginosa from Portugal
    Olga Cardoso
    Laboratório de Microbiologia C E F da Faculdade de Farmácia da Universidade de Coimbra, Portugal
    Microb Drug Resist 8:93-7. 2002
    ..The pulsed-field gel electrophoresis (PFGE) patterns of these isolates were indistinguishable, suggesting dissemination to the community of this VIM-2 producer...
  94. pmc Multidrug-resistant Acinetobacter baumannii, Russia
    Thierry Naas
    Emerg Infect Dis 13:669-71. 2007
  95. pmc Inducible AmpC beta-lactamase of a new member Enterobacteriaceae
    Richard Bonnet
    Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
    Antimicrob Agents Chemother 46:3316-9. 2002
    ....
  96. pmc Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis
    Isabel C Materon
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 47:2040-2. 2003
    ..MIC measurements and steady-state kinetic analyses indicate that Bla1 possesses penicillinase activity while Bla2 possesses penicillinase, cephalosporinase, and carbapenem-hydrolyzing activities...
  97. ncbi Molecular characterization of the gene encoding a new AmpC beta-lactamase in Acinetobacter baylyi
    Alejandro Beceiro
    Servicio de Microbiología Unidad de Investigación, Complejo Hospitalario Universitario Juan Canalejo, Xubias de Arriba 84, 15006 La Coruna, Spain
    J Antimicrob Chemother 59:996-1000. 2007
    ..The main objective of the present study was to demonstrate the presence of a beta-lactamase ampC gene in the chromosome of the non-pathogenic bacterium Acinetobacter baylyi ADP1...
  98. ncbi Antimicrobial activity of beta-lactam antibiotics against clinical pathogens after molecular inclusion in several cyclodextrins. A novel approach to bacterial resistance
    G Athanassiou
    Department of Microbiology, School of Medicine, University of Athens, Goudi, Athens 11527, Greece
    J Pharm Pharmacol 55:291-300. 2003
    ....
  99. ncbi Using steric hindrance to design new inhibitors of class C beta-lactamases
    Indi Trehan
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Chem Biol 9:971-80. 2002
    ..ATMO-penicillin binds in a catalytically incompetent conformation resembling that adopted by third-generation cephalosporins, demonstrating the transferability of such sterically hindered groups in inhibitor design...
  100. pmc Identification of the novel narrow-spectrum beta-lactamase SCO-1 in Acinetobacter spp. from Argentina
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, 78 rue du General Leclerc, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 51:2179-84. 2007
    ..40% with the enzymes TEM, SHV, and CTX-M. A gene encoding a putative resolvase was identified downstream of the bla(SCO-1) gene, but its precise way of acquisition remains to be determined...
  101. pmc Cytoplasmic-membrane anchoring of a class A beta-lactamase and its capacity in manifesting antibiotic resistance
    Maxim Suvorov
    Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA
    Antimicrob Agents Chemother 51:2937-42. 2007
    ..It is conceivable that an evolutionary outcome could be the shedding of the sequence for the membrane anchor or alternatively evolution of these enzymes from nonanchored progenitors...

Research Grants52

  1. An Integrated Diagnostic System for Rapid Antimicrobial Susceptibility Testing
    VINCENT JEN JR GAU; Fiscal Year: 2013
    ..A separate Milestones and Timeline section is included at the end of the Research Strategy. ..
  2. Characterizing Beta Lactams as Neuroprotectants for Amyotrophic Lateral Sclerosis
    Jeffrey D Rothstein; Fiscal Year: 2010
    ..These sequential phases will set the stage for future practical translation towards rational clinical trial design. ..
  3. Cranberry: Interactions with Anti-infectious Agents
    Gail Anderson; Fiscal Year: 2005
    ..abstract_text> ..
  4. Mechanism and Inhibition of Bacterial Transglycosylases and Transpeptidases.
    Suzanne Walker; Fiscal Year: 2013
    ..The results of the experiments in Aim III have implications for new approaches to overcome MRSA that involve combining a beta-lactam with compounds that target other proteins involved in methicillin resistance. ..
  5. Molecular Archaeology: Vintage Beta Lactams for Resistant Gram Negative Infectio
    Marvin J Miller; Fiscal Year: 2013
    ..Conduct in vitro toxicology battery and pilot toxicology studies. Aim 5. Conduct 14-day range-finding toxicology studies. Upon successful completion of this project, we will be ready to proceed into IND-enabling toxicology studies. ..
  6. Discovery of Small Molecules that Restore Methicillin Sensitivity to MRSA
    JENNIFER CAMPBELL O apos NEILL; Fiscal Year: 2010
    ..the expression of WTAs by inhibiting the first enzyme in the WTA pathway (TarO) will render MRSA susceptible to beta lactams. Consistent with this hypothesis, preliminary studies have shown that tunicamycin, a natural product that ..
  7. Cell-based HTS for Compounds that Block Virulence Factor Expression in MRSA
    Suzanne Walker; Fiscal Year: 2009
    ..WTAs by inhibiting one of the first two enzymes in the WTA pathway (TarO/TarA) will render MRSA susceptible to beta lactams. Consistent with this hypothesis, preliminary studies have shown that tunicamycin, a natural product that ..
  8. Epidemiology of Community-Associated, ESBL-Producing Escherichia coli
    Yohei Doi; Fiscal Year: 2010
    ..coli in the community may lead to treatment failures of common infections such as urinary tract infection. The proposed study intends to collect data on the occurrence of such infections across the United States. ..
  9. Novel Mechanisms of Beta-lactam Resistance in Staph Aureus
    Binh An Diep; Fiscal Year: 2012
    ..The overall goal of the proposed research is to define the molecular basis for mecA-independent resistance to ?-lactams, which could lead to a better understanding of ?-lactam antibiotic effects and identification of novel drug targets. ..
  10. BIOSYNTHESIS OF BETA-LACTAM ANTIBIOTICS
    CRAIG ARTHUR TOWNSEND; Fiscal Year: 2013
    ..abstract_text> ..
  11. The use of mass spectrometry for rapid detection of carbapenemase-producing bacte
    DAVID RYAN PEAPER; Fiscal Year: 2013
    ..Future phases of development will apply the technology to primary specimens, which will be followed by multicenter clinical trials in pursuit o FDA 510(k) clearance of the final product. ..
  12. NUCLEIC ACID PROBES OF RIBOSOMAL STRUCTURE AND FUNCTION
    BARRY COOPERMAN; Fiscal Year: 2003
    ..abstract_text> ..
  13. REACTIVITY MODELS FOR ISOPENICILLIN N SYNTHETASE
    PATRICIA SHAPLEY; Fiscal Year: 1992
    ..Also, the development of transition metal catalysts for the stereoselective formation of beta-lactam rings could lead to the chemical synthesis of new antibiotics...
  14. Enantioselective Thiourea-Catalyzed Syntheses of beta-Lactones and beta-Lactams
    PAMELA MICHELE TADROSS; Fiscal Year: 2013
    ....
  15. H. INFLUENZAE: PENICILLIN BINDING PROTEINS & CELL WALL
    Paul Mendelman; Fiscal Year: 1991
    ....
  16. NOVEL LINKAGES OF THE PEPTIDOGLYCAN LAYER: ADAPTATION &RESISTANCE TO B-LACTAMS
    Gyanu Lamichhane; Fiscal Year: 2011
    ..This would be essential for development of drugs targeting L,D-transpeptidation to treat TB with a novel mechanism. Therefore, this proposal underscores the mission and priorities of NIH-NIAID. ..
  17. REGULATION OF BETA-LACTAMASE IN STAPHYLOCOCCUS AUREUS
    Corinne Hackbarth; Fiscal Year: 2000
    ..aureus beta-lactamase regulatory system using construction of uninducible and constitutive mutants. ..
  18. BIOSYNTHESIS OF BETA LACTAM ANTIBIOTICS
    Craig Townsend; Fiscal Year: 2003
    ..These insights will be extended to examination of beta- lactam formation in the prephytotoxin tabtoxin. ..
  19. Antibiotic Hypersusceptibility Mutations in Bacteria
    Alexander Mankin; Fiscal Year: 2005
    ..In addition to identifying promising targets for potentiators, the project will help unravel new aspects of the mechanism of action of antibiotics and new features of bacterial physiology. ..
  20. METALLO BETA LACTAMASE FROM X MALTOPHILIA
    Michael Crowder; Fiscal Year: 2002
    ....
  21. MOLECULAR GENETICS OF PLASMID-DETERMINED BETA-LACTAMASE
    George Jacoby; Fiscal Year: 1990
    ..5. To analyze the contribution of amino acids making up the walls of the enzyme active site to substrate specificity by systematic site-directed mutagenesis...
  22. 400 MHz NMR Spectrometer for Shared Use
    Craig Townsend; Fiscal Year: 2004
    ..9) investigation of the hypothesis that aromatic amino acids are required to specify a distinct conformational state by NMR spin relaxation techniques, to elucidate important parameters for protein design. ..
  23. STRUCTURE/FUNCTION OF ENGINEERED B LACTAMASES
    Osnat Herzberg; Fiscal Year: 2002
    ..This mutant and the native proteins will serve as the parent molecules for engineering a carboxypeptidase activity toward D-Ala-D-ala peptide, the natura substrate of the bacterial cell wall peptidases. ..
  24. MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN STAPHYLOCOCCI
    Robert Daum; Fiscal Year: 2006
    ..These studies should lead to an understanding of the mechanisms by which S. aureus resist the bactericidal effect of GPs and hopefully can identify new ideas regarding therapy of infections caused by resistant isolates. ..
  25. SEMISYNTHETIC TAXOL DERIVATIVES
    Gunda Georg; Fiscal Year: 1992
    ..All of the newly synthesized compounds will be tested in the microtubule assembly test and against B-16 melanoma cell growth. Promising taxol derivatives will be evaluated further, and also provided to the NCI...
  26. NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS
    K Sharpless; Fiscal Year: 1999
    ..Encouraged by the successful asymmetric dihydroxylation of isolated olefins, a continuing long-range goal of this project is asymmetric epoxidation of isolated olefins. ..
  27. METHODS APPLICABLE TO B-LACTAM AND ALKALOID SYNTHESES
    HARRY WASSERMAN; Fiscal Year: 1991
    ..In another phase of our work we will study the imino epoxide rearrangement as a pathway to the synthesis of piperidine alkaloids with a high degree of stereochemical control...
  28. Beta-lactamase Antibiotic Resistance of B. anthracis
    Hong zhong Zhang; Fiscal Year: 2004
    ..The result of this study will elucidate the molecular mechanism underlying the resistance of Bacillus anthracis to penicillin antibiotics and inform decisions about the clinical utility of Beta-lactam antibiotics. ..
  29. ORGANOMETALLIC REAGENTS FOR STEREOCONTROLLED SYNTHESIS
    JOHN FALLER; Fiscal Year: 1992
    ..We anticipate, for example, the generation of new reagents applicable to key steps in asymmetric syntheses of beta-lactams, which are important to the development of modern antibiotics based on analogues of penicillin...
  30. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  31. Beta-Lactamases and DD-Peptidases: Active Site Chemistry
    REX PRATT; Fiscal Year: 2008
    ..These studies will lead to new insight into the chemistry of [unreadable]-lactamase and transpeptidase active sites, and thus to new directions in antibiotic design. ..
  32. Novel Targets for Treatment of Pseudomonas aeruginosa
    Philip Lister; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  33. Beta-Lactamases and DD-Peptidases: Active Site Chemistry
    Rex F Pratt; Fiscal Year: 2010
    ..E Gyp 0-. ... G'O --a tail ... 'Fn "-'a'- .N. >.t (Nn Nn. om' m' "L" O-- Oil 0.0)-7-.o 9,' -_p >'7 ='L ..
  34. Gordon Research Conference on Staphylococcal Diseases
    BRIGITTE BERGER BACHI; Fiscal Year: 2003
    ..S. This will afford a unique and rich opportunity for fellowship and scientific exchange between young and established investigators in the field. ..
  35. Dual Purpose b-Lactamase Inhibitors
    JOHN BUYNAK; Fiscal Year: 2004
    ..A group of scientists, including chemists, microbiologists, enzymologists, and crystallographers has been assembled to allow rapid optimization of SAR. ..
  36. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  37. REGULATION OF NEUTROPHIL OXIDATIVE RESPONSES IN TRAUMA
    Joseph Solomkin; Fiscal Year: 2004
    ..Together, these studies will define potential points for therapeutic intervention and provide important insight into regulation of the acute inflammatory response. ..
  38. A Mechanistically Novel Antibiotic for Anthrax
    Edward Turos; Fiscal Year: 2004
    ..Thus, finding suitable compounds that could be brought into Phase II is critical. ..
  39. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
    ..These projected investigations should generate substantial new knowledge about complex synthesis as well as providing additional insight into some of the bioactivity exhibited by the subject natural products. ..
  40. Optimizing dosing to prevent antibiotic resistance
    Martin Evans; Fiscal Year: 2005
    ..We believe understanding the mechanisms underlying resistance will enhance our ability to design alternative dosing strategies to effect clinical cure. ..
  41. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  42. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
  43. Chronic Prostatitis Collaborative Research Network CPCRN
    J Nickel; Fiscal Year: 2007
    ..Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with CPPS in clinical studies and will be a valuable partner in the proposed CPCRN and UCPPSCG. ..
  44. Strategies for Selective Covalent Conjugation of Proteins with Small Molecules
    Fujie Tanaka; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. Multicenter Trial of Daily Chlorhexidine Bathing to Reduce Nosocomial Infections
    Michael Climo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  46. Cannabinoid Regulation of Basal Ganglia Glutamate and GABA
    SCOTT RAWLS; Fiscal Year: 2007
    ..Our outcomes will be a first step in determining whether blocking endocannabinoid inactivation offers any therapeutic advantage over direct activation of cannabinoid receptors with marijuana. [unreadable] [unreadable] [unreadable]..
  47. Defining Moxifloxacin as a First-line TB Drug
    Eric Nuermberger; Fiscal Year: 2008
    ..Relevance: Results of these studies will help to define optimal treatment regimens for TB that can be used to design new clinical trials or, in some cases, directly applied to clinical practice. ..
  48. Can beta-lactam antibiotics decrease morphine physical dependence?
    SCOTT RAWLS; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. EVALUATION OF NIKKOMYCIN Z PHARMACOLOGY FOR TREATMENT OF UNCOMPLICATED COCCIDIODE
    David Nix; Fiscal Year: 2009
    ..By carrying out the proposed work, the investigators will resume the clinical development of nikkomycin Z as a potentially curative therapy for coccidioidomycosis so that it may become a candidate for final commercial development. ..
  50. N-Thiolated Beta-Lactams
    Edward Turos; Fiscal Year: 2006
    ..We believe that these studies will provide extraordinary opportunities to develop new therapeutics and approaches for the control of hospital-borne drug-resistant infections. ..