raclopride

Summary

Summary: A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.

Top Publications

  1. ncbi Interaction of raclopride and preparatory interval effects on simple reaction time performance
    Christopher J MacDonald
    Department of Psychology and Neuroscience, Genome Sciences Research Building II, 3rd Floor, 572 Research Drive, Box 91050, Duke University, Durham, NC 27708, United States
    Behav Brain Res 175:62-74. 2006
  2. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
  3. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
  4. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007
  5. ncbi Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:1027-35. 2002
  6. pmc Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study
    Nina B L Urban
    New York State PsychiatricInstitute, Department of Psychiatry, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 71:677-83. 2012
  7. ncbi In vivo detection of striatal dopamine release during reward: a PET study with [(11)C]raclopride and a single dynamic scan approach
    S Pappata
    INSERM U334, Service Hospitalier Frederic Joliot, 4 Place du General Leclerc, 91401, Orsay, France
    Neuroimage 16:1015-27. 2002
  8. ncbi Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study
    Alexandra Soliman
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Neuropsychopharmacology 33:2033-41. 2008
  9. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
  10. ncbi Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
    Biol Psychiatry 58:908-12. 2005

Detail Information

Publications237 found, 100 shown here

  1. ncbi Interaction of raclopride and preparatory interval effects on simple reaction time performance
    Christopher J MacDonald
    Department of Psychology and Neuroscience, Genome Sciences Research Building II, 3rd Floor, 572 Research Drive, Box 91050, Duke University, Durham, NC 27708, United States
    Behav Brain Res 175:62-74. 2006
    ..In Experiment 3, 100 microg/kg i.p. of raclopride proportionally slowed RT as a function of the PI...
  2. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ..D2 receptor availability (V3") was measured with positron emission tomography and [11C]raclopride in 14 healthy volunteers under control conditions and after the intravenous administration of amphetamine (0...
  3. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  4. ncbi Conditioned dopamine release in humans: a positron emission tomography [11C]raclopride study with amphetamine
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:3998-4003. 2007
    ..In the present study, we used positron emission tomography and [11C]raclopride to investigate whether amphetamine-predictive stimuli can elicit striatal dopamine release in humans...
  5. ncbi Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 27:1027-35. 2002
    Eight healthy men underwent two positron emission tomography (PET) [11C]raclopride scans, one following placebo, the second following d-amphetamine (0.30 mg/kg, p.o.)...
  6. pmc Dopamine release in chronic cannabis users: a [11c]raclopride positron emission tomography study
    Nina B L Urban
    New York State PsychiatricInstitute, Department of Psychiatry, 1051 Riverside Drive, New York, NY 10032, USA
    Biol Psychiatry 71:677-83. 2012
    ..D(2/3) availability and DA release in abstinent cannabis users compared with control subjects and explored relationships to cannabis use history using [(11)C]raclopride positron emission tomography and an amphetamine challenge paradigm.
  7. ncbi In vivo detection of striatal dopamine release during reward: a PET study with [(11)C]raclopride and a single dynamic scan approach
    S Pappata
    INSERM U334, Service Hospitalier Frederic Joliot, 4 Place du General Leclerc, 91401, Orsay, France
    Neuroimage 16:1015-27. 2002
    A new simple method is proposed to detect, using PET and [(11)C]raclopride, changes in striatal extracellular dopamine concentration during a rewarded effortful task...
  8. ncbi Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study
    Alexandra Soliman
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Neuropsychopharmacology 33:2033-41. 2008
    ..Using positron emission tomography and [(11)C]raclopride, we measured changes in synaptic dopamine concentrations in 10 controls and 16 psychometric schizotypes; 9 with ..
  9. ncbi Elevated putamen D(2) receptor binding potential in major depression with motor retardation: an [11C]raclopride positron emission tomography study
    Jeffrey H Meyer
    College Clarke Site, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, 250 College St, Toronto, Ontario M5T 1R8, Canada
    Am J Psychiatry 163:1594-602. 2006
    ..Striatal [(11)C]raclopride binding potential measured with positron emission tomography is an index of D(2) type receptors and is sensitive ..
  10. ncbi Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
    Biol Psychiatry 58:908-12. 2005
    ..Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN)...
  11. ncbi Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men
    Isabelle Boileau
    McConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada
    Arch Gen Psychiatry 63:1386-95. 2006
    ..A similar phenomenon, referred to as endogenous sensitization, is also believed to play a role in the emergence of positive symptoms in patients with schizophrenia...
  12. ncbi Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain
    Paul Cumming
    PET Center, Arhus Kommunehospital, Nørrebrogade 44, Arhus, Denmark
    Neuroimage 19:1127-36. 2003
    ..It is well known that the specific binding of [(11)C]raclopride to dopamine D(2,3) receptors in living striatum is reduced by cocaine and amphetamines, revealing increased ..
  13. pmc Within-subject comparison of [(11)C]-(+)-PHNO and [(11)C]raclopride sensitivity to acute amphetamine challenge in healthy humans
    Paul Shotbolt
    GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London, UK
    J Cereb Blood Flow Metab 32:127-36. 2012
    ..be more affected by acute fluctuations in synaptic dopamine than that of antagonist radiotracers such as [(11)C]raclopride. In this study, the authors compared the effects of an oral dose of the dopamine releaser amphetamine (0...
  14. ncbi Power fluctuations in beta and gamma frequencies in rat globus pallidus: association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors
    Cyril Dejean
    Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
    J Neurosci 31:6098-107. 2011
    ..Disruption of this hierarchical organization and subsequent disordered beta-gamma balance in basal ganglia disorders such as Parkinson's disease may be important in the pathogenesis of their symptoms...
  15. ncbi Comparative effects of methamphetamine and nicotine on the striatal [(11)C]raclopride binding in unanesthetized monkeys
    Hideo Tsukada
    Central Research Laboratory, Hamamatsu Photonics K K, 5000 Hirakuchi, Hamakita, Shizuoka 434 8601, Japan
    Synapse 45:207-12. 2002
    ..Release of dopamine in the striatum using [(11)C]raclopride was determined indirectly in four nicotine-naïve adult Macaca mulatta monkeys under conscious and isoflurane-..
  16. ncbi MK-801-induced hyperlocomotion: differential effects of M100907, SDZ PSD 958 and raclopride
    P Martin
    Department of Pharmacology, Goteborg University, Sweden
    Eur J Pharmacol 335:107-16. 1997
    ..10% of controls (at 8 mg/kg i.p.). The dopamine D2 receptor antagonist raclopride ([(-)-(S)-3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl) methyl)-6-methoxy-salicylamide tartrate]; 0.11, 0.33, 1...
  17. ncbi Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task
    J D Salamone
    Department of Psychology, University of Connecticut, Storrs, CT 06269 1020, USA
    Psychopharmacology (Berl) 160:371-80. 2002
    ..In previous work with this task, dopamine antagonists and accumbens dopamine depletions decreased lever pressing but increased chow consumption...
  18. ncbi Essential role of dopamine D2 receptor in the maintenance of wakefulness, but not in homeostatic regulation of sleep, in mice
    Wei Min Qu
    Department of Pharmacology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai 200032, China
    J Neurosci 30:4382-9. 2010
    ..The D(2)R antagonist raclopride mimicked these effects in WT mice...
  19. ncbi Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 27:12700-6. 2007
    ..measuring brain glucose metabolism with [18F]fluorodeoxyglucose) and dopamine increases (measured with [11C]raclopride, a D2/D3 receptor ligand with binding that is sensitive to endogenous dopamine) induced by the stimulant drug ..
  20. ncbi In vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: differential findings with [3H]raclopride versus [3H]spiperone
    W Sun
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Mol Pharmacol 63:456-62. 2003
    Competition with endogenous dopamine (DA) is usually invoked to explain changes in [(11)C]raclopride binding observed after amphetamine administration in animals and humans...
  21. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..with PET in healthy humans and compared with that of the reference D(2/3) receptor antagonist radiotracer [11C]raclopride. Ten subjects (eight females and two males) were studied on two separate days, a minimum of 1 week apart, both ..
  22. ncbi The D2/3 dopamine receptor in pathological gambling: a positron emission tomography study with [11C]-(+)-propyl-hexahydro-naphtho-oxazin and [11C]raclopride
    Isabelle Boileau
    Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, ON, Canada
    Addiction 108:953-63. 2013
    ....
  23. ncbi Dopaminergic modulation of motor maps in rat motor cortex: an in vivo study
    J A Hosp
    Clinical Neurorehabilitation, Department of Neurology, University of Zurich, Frauenklinikstr 26, 8091 Zurich, Switzerland
    Neuroscience 159:692-700. 2009
    ..maleate, SCH 23390) or D2-receptor (raclopride) antagonists into the M1 forelimb area of rats. Stimulation mapping of M1 was repeated after 24 h...
  24. pmc Lateralization and gender differences in the dopaminergic response to unpredictable reward in the human ventral striatum
    Chantal Martin-Soelch
    Department of Psychiatry and Psychotherapy, University Hospital Zurich, Culmannstrasse 8, CH 8091, Zurich, Switzerland
    Eur J Neurosci 33:1706-15. 2011
    ..Using [¹¹C]raclopride-PET to assess the striatal DA response to unpredictable monetary rewards, we hypothesized that such rewards ..
  25. ncbi Study of the behavioural responses related to the potential addictive properties of MDMA in mice
    Patricia Robledo
    Laboratori de Neurofarmacologia, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, C Dr Aiguader 80, 08003 Barcelona, Spain
    Naunyn Schmiedebergs Arch Pharmacol 369:338-49. 2004
    ..25 and 1 mg/kg), timolol (2 and 10 mg/kg), prazosin (0.25 and 1 mg/kg), SCH 23390 (0.05 and 0.25 mg/kg), raclopride (0.1 and 0.5 mg/kg) or vehicle, and several somatic manifestations of withdrawal were evaluated for 45 min...
  26. pmc Striatal dopamine release during performance of executive functions: A [(11)C] raclopride PET study
    Oury Monchi
    Functional Neuroimaging Unit, University of Montreal, Montreal, Quebec, Canada
    Neuroimage 33:907-12. 2006
    ..We used D2-dopamine receptor ligand [(11)C] raclopride PET in healthy subjects while performing the Montreal Card Sorting Task (MCST)...
  27. pmc Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
    T D L Steeves
    Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada
    Brain 132:1376-85. 2009
    ..We describe results of a [(11)C] raclopride positron emission tomography (PET) study comparing dopaminergic function during gambling in Parkinson's disease ..
  28. ncbi Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section and Stockholm Brain Institute, R5 02, Karolinska Hospital, 17176, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1639-50. 2009
    ..This study assessed the quantitative improvements provided by the implementation of the PSF modelling in the reconstruction of the PET data using the High Resolution Research Tomograph (HRRT)...
  29. ncbi Dopamine displaces [3H]domperidone from high-affinity sites of the dopamine D2 receptor, but not [3H]raclopride or [3H]spiperone in isotonic medium: Implications for human positron emission tomography
    Philip Seeman
    Department of Pharmacology, University of Toronto, 1 King s College Circle, Medical Sciences Building Room 4344, Toronto, Ontario, Canada M5S JA8
    Synapse 49:209-15. 2003
    ..The present data show that, in contrast to [(3)H]spiperone or [(3)H]raclopride, [(3)H]domperidone labels D2High sites in the presence of isotonic NaCl in either striatum or cloned D2Long ..
  30. ncbi Relationships among ventral striatal dopamine release, cortisol secretion, and subjective responses to amphetamine
    Lynn M Oswald
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychopharmacology 30:821-32. 2005
    ..healthy adults, ages 18-27 years, underwent two consecutive 90-min PET studies with high specific activity [11C]raclopride. The first scan was preceded by intravenous saline, and the second by intravenous amphetamine (AMPH 0.3 mg/kg)...
  31. ncbi C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
    M Hirvonen
    Mol Psychiatry 9:1060-1. 2004
  32. pmc Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
    J Neurosci 28:8454-61. 2008
    ..We studied 15 healthy subjects using positron emission tomography and [11C]raclopride (dopamine D2/D3 receptor radioligand) and [11C]cocaine (dopamine transporter radioligand)...
  33. ncbi Dopamine release in the human striatum: motor and cognitive tasks revisited
    Julia M Lappin
    Institute of Psychiatry, King s College London, London, UK
    J Cereb Blood Flow Metab 29:554-64. 2009
    ..Dopamine release was quantified using [(11)C]-raclopride in two studies using a triple-scan approach, comprising active task, motor control, and rest...
  34. pmc Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study
    Ji H Ko
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Eur J Neurosci 28:2147-55. 2008
    ..to transiently disrupt its function and to measure MCST performance and striatal dopamine release during [(11)C]raclopride PET. A significant hemispheric asymmetry was observed...
  35. ncbi The hedonic response to cigarette smoking is proportional to dopamine release in the human striatum as measured by positron emission tomography and [11C]raclopride
    Sean P Barrett
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Synapse 54:65-71. 2004
    Positron emission tomography and [11C]raclopride were used to assess the dopaminergic response to cigarette smoking in ten smokers. Nicotine-deprived smokers were scanned twice on separate days...
  36. ncbi Mesolimbic dopamine release is linked to symptom severity in pathological gambling
    Juho Joutsa
    Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
    Neuroimage 60:1992-9. 2012
    ..Human reward-seeking gambling behavior, and especially pathological gambling, has been presumed to be modulated by brain dopamine...
  37. pmc Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]raclopride
    Nina B L Urban
    Department of Psychiatry at New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA
    Biol Psychiatry 68:689-96. 2010
    We used a positron emission tomography paradigm with the D2/3 radiotracer [¹¹C]raclopride and an alcohol challenge to examine the magnitude of alcohol-induced dopamine release and compare it between young men and women.
  38. ncbi A novel method for noninvasive detection of neuromodulatory changes in specific neurotransmitter systems
    Nathaniel M Alpert
    Division of Nuclear Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimage 19:1049-60. 2003
    ..A human study was conducted to confirm the predictions of simulation using (11)C-raclopride and a motor planning task...
  39. ncbi Comparison of rat dopamine D2 receptor occupancy for a series of antipsychotic drugs measured using radiolabeled or nonlabeled raclopride tracer
    Vanessa N Barth
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, 46285, USA
    Life Sci 78:3007-12. 2006
    ..were generated for 8 antipsychotic compounds in parallel experiments using either radiolabeled or unlabeled raclopride tracer...
  40. ncbi Effect of amphetamine on dopamine D2 receptor binding in nonhuman primate brain: a comparison of the agonist radioligand [11C]MNPA and antagonist [11C]raclopride
    Nicholas Seneca
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Karolinska Hospital, S 17176 Stockholm, Sweden
    Synapse 59:260-9. 2006
    ..to assess and compare the sensitivity of the agonist radioligand [(11)C]MNPA and antagonist radioligand [(11)C]raclopride to synaptic DA levels...
  41. ncbi Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus
    A P Strafella
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 21:RC157. 2001
    ..Here we used [(11)C]raclopride and positron emission tomography to measure changes in extracellular dopamine concentration in vivo after ..
  42. ncbi Positron emission tomography and ex vivo and in vitro autoradiography studies on dopamine D2-like receptor degeneration in the quinolinic acid-lesioned rat striatum: comparison of [11C]raclopride, [11C]nemonapride and [11C]N-methylspiperone
    Kiichi Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1 Naka cho, Itabashi ku, 172 0022, Tokyo, Japan
    Nucl Med Biol 29:307-16. 2002
    With [11C]raclopride,[11C]nemonapride and [11C]N-methylspiperone, degeneration of dopamine D2-like receptors in the unilaterally quinolinic acid-lesioned rats was evaluated by positron emission tomography (PET) and ex vivo and in vitro ..
  43. ncbi Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method
    Richard J A Goodwin
    Global Distribution Imaging, DMPK IM, AstraZeneca R and D, Sodertalje, Sweden
    Anal Chem 83:9694-701. 2011
    ..dopamine receptor antagonist 3,5-dichloro-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide (raclopride) and the D1 dopamine receptor antagonist 7-chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol (SCH ..
  44. ncbi [3H]raclopride binding to brain tissue from subjects with schizophrenia: methodological aspects
    B Dean
    Rebecca L Cooper Research Laboratories, Mental Health Research Institute of Victoria, Parkville, Australia
    Neuropharmacology 36:779-86. 1997
    The binding of [3H]raclopride to particulate membrane and frozen sections (with quantitative autoradiography) from the caudate-putamen, obtained at autopsy from schizophrenic and non-schizophrenic subjects, was measured...
  45. ncbi Multiinjection approach for D2 receptor binding quantification in living rats using [11C]raclopride and the beta-microprobe: crossvalidation with in vitro binding data
    Gweltas Mauger
    Unité de Recherche Associée Commissariat á l Energie Atomique Centre National de La Recherche Scientifique, Orsay, France
    J Cereb Blood Flow Metab 25:1517-27. 2005
    The purpose of this study was to quantify D2 receptors density and affinity in living rats using [11C]raclopride and to validate the multiinjection modelling approach...
  46. ncbi In vitro and in vivo comparison of [³H](+)-PHNO and [³H]raclopride binding to rat striatum and lobes 9 and 10 of the cerebellum: a method to distinguish dopamine D₃ from D₂ receptor sites
    Béla Kiss
    Department of Molecular Pharmacology, Pharmacological and Safety Research, Gedeon Richter Plc, 1103 Budapest, Gyomroi u 19 21, Hungary
    Synapse 65:467-78. 2011
    In vitro binding characteristics of the dopamine D₃/D₂ antagonist [³H]raclopride were compared to the D₃/D₂ agonist [³H](+)-PHNO in membrane preparations from rat striatum, cerebellum Lobules 9 and 10 (CB L9,10), and other ..
  47. pmc Evaluating dopamine reward pathway in ADHD: clinical implications
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, MSC 9581, Bethesda, MD 20892, USA
    JAMA 302:1084-91. 2009
    ....
  48. ncbi In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET
    Panayotis K Thanos
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    J Nucl Med 43:1570-7. 2002
    ..MRI has been used to image brain structural changes in KO mice but, to our knowledge, the feasibility of using PET to investigate brain neurochemistry in KO mice has not been demonstrated...
  49. ncbi MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain
    Pedro Rosa-Neto
    Center for Functionally Integrative Neuroscience, Aarhus University and PET Center, Aarhus University Hospitals, Aarhus C, 8000, Denmark
    Synapse 53:222-33. 2004
    ..Using PET, we measured the binding potentials (pBs) of the benzamide [11C]raclopride and the butyrophenone N-[11C]methylspiperone ([11C]NMSP) in brain of living pigs first in a baseline condition ..
  50. ncbi The combination of nicotine with the D2 antagonist raclopride or the weak D4 antagonist L-745,870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex
    Kent Jardemark
    Karolinska Institutet, Department of Physiology and Pharmacology, Section of Neuropsychopharmacology, Stockholm, Sweden
    Int J Neuropsychopharmacol 8:157-62. 2005
    ..receptor-mediated neurotransmission in the mPFC, when given alone or in combination with a D(2,3) antagonist, raclopride, or a D4 antagonist, 3-(4-[4-chlorophenyl]piperazin-1-yl)methyl-1H-pyrrolo[2,3b]pyridine (L-745,870), using ..
  51. ncbi PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow
    Wadad Hassoun
    CERMEP, Lyon, France
    Eur J Nucl Med Mol Imaging 30:141-8. 2003
    ..The binding potential for [(11)C]raclopride (BP(raclo)), a radioligand with good specificity for dopamine (DA) receptors of the D(2) type, was measured in ..
  52. ncbi Effects of single and repeated administration of 1,2,3,4-tetrahydroisoquinoline analogs on the binding of [11C]raclopride to dopamine D2 receptors in the mouse brain
    K Ishiwata
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Itabashi, Japan
    J Neural Transm 108:1111-25. 2001
    ..TIQ) analogs and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the binding of [11C]raclopride to striatal dopamine D2 receptors in mice...
  53. ncbi Temporal characterisation of amphetamine-induced dopamine release assessed with [11C]raclopride in anaesthetised rodents
    Gavin C Houston
    MRC Cyclotron Unit, Hammersmith Hospital, London W12 ONN, UK
    Synapse 51:206-12. 2004
    ..For example, carbon-11 labelled raclopride has been effectively used to monitor dopamine release following pharmacological and behavioural manipulations...
  54. ncbi Oral D-amphetamine causes prolonged displacement of [11C]raclopride as measured by PET
    Laura Cardenas
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Synapse 51:27-31. 2004
    ..administered D-amphetamine has been used as a challenge drug to release dopamine, which in turns inhibits [11C]raclopride binding to dopaminergic D2 receptors as measured using positron emission tomography (PET) techniques...
  55. ncbi Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals
    Vinal D Patel
    Medical Department, Brookhaven National Laboratory, Upton NY 11973, USA
    Neuroimage 41:1051-66. 2008
    ..a catheterized line and permitted to move freely for 30 min during uptake of the imaging agent, in this case 11C-raclopride. After this Awake Uptake period, animals are anesthetized and scanned for 25 min...
  56. ncbi Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge
    Paul R A Stokes
    MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK
    Neuroimage 52:1521-7. 2010
    ..In man, striatal dopamine release can be indexed using [11C]-raclopride positron emission tomography (PET), and recent reports suggest that cortical [11C]-raclopride binding may also ..
  57. ncbi A simple loop method for the automated preparation of (11C)raclopride from (11C)methyl triflate
    R Iwata
    Graduate School of Engineering, Tohoku University, Sendai, Japan
    Appl Radiat Isot 55:17-22. 2001
    A simple automated preparation of [11C]raclopride by reaction of [11C]methyl triflate with demethylraclopride triflate is described...
  58. ncbi An extended simplified reference tissue model for the quantification of dynamic PET with amphetamine challenge
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC room 3245, Baltimore, MD 21287, USA
    Neuroimage 33:550-63. 2006
    ..Violations of this assumption may result in unreliable estimation of the amphetamine-induced percent change in the binding potential (DeltaBP%)...
  59. ncbi Specific [3H]raclopride binding to neostriatal dopamine D2 receptors: role of disulfide and sulfhydryl groups
    T A Reader
    Department de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neurochem Res 17:749-59. 1992
    ..binding studies were performed in rabbit neostriatum (caudate-putamen) using the dopamine D2 antagonist [3H]raclopride. Treatment of the membrane preparations with the reducing agent L-dithiothreitol (L-DTT) as well as with the ..
  60. ncbi Wavelet-based resolution recovery using an anatomical prior provides quantitative recovery for human population phantom PET [¹¹C]raclopride data
    M Shidahara
    Division of Medical Physics, Tohoku University Graduate School of Medicine, Sendai, Japan
    Phys Med Biol 57:3107-22. 2012
    ..of this study was to evaluate a resolution recovery (RR) method using a variety of simulated human brain [¹¹C]raclopride positron emission tomography (PET) images...
  61. ncbi D2-receptor upregulation is dependent upon temporal course of D2-occupancy: a longitudinal [11C]-raclopride PET study in cats
    Nathalie Ginovart
    The Vivian Rakoff Positron Emission Tomography Unit, Centre for Addiction and Mental Health and University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 34:662-71. 2009
    ..D(2)-receptors were measured using positron emission tomography and Scatchard analyses of [(11)C]raclopride binding, before and after withdrawal of treatment...
  62. ncbi Cholinergic neuronal modulation alters dopamine D2 receptor availability in vivo by regulating receptor affinity induced by facilitated synaptic dopamine turnover: positron emission tomography studies with microdialysis in the conscious monkey brain
    H Tsukada
    Central Research Laboratory, Hamamatsu Photonics K K, Shizuoka 434 8601, Japan
    J Neurosci 20:7067-73. 2000
    ..For assessment of dopamine D(2) receptor binding in vivo, [(11)C]raclopride was applied because this labeled compound, which has relatively low affinity to dopamine D(2) receptors, was ..
  63. ncbi A positron emission tomography study examining the dopaminergic activity of armodafinil in adults using [¹¹C]altropane and [¹¹C]raclopride
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 68:964-70. 2010
    ..With positron emission tomography imaging, we determined DAT occupancy and changes in extracellular dopamine by armodafinil in vivo...
  64. ncbi Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Psychopharmacol 25:1329-36. 2011
    ..receptor binding was quantified before and after treatment as the binding potential (BP (ND)) using [(11)C]raclopride and 3D positron emission tomography...
  65. ncbi Baclofen, raclopride, and naltrexone differentially affect intake of fat and sucrose under limited access conditions
    Rebecca L Corwin
    Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, Chandlee Laboratory University Park, Pennsylvania 16802, USA
    Behav Pharmacol 20:537-48. 2009
    ..Effects of baclofen (GABAB agonist), SCH 23390 (D1 antagonist), raclopride (D2 antagonist), and naltrexone (opioid antagonist) were assessed...
  66. ncbi Combined striatal binding and cerebral influx analysis of dynamic 11C-raclopride PET improves early differentiation between multiple-system atrophy and Parkinson disease
    Koen Van Laere
    Division of Nuclear Medicine, Leuven University Hospital and Katholieke Universiteit Leuven, Leuven, Belgium
    J Nucl Med 51:588-95. 2010
    ..We investigated whether the differential diagnostic value of (11)C-raclopride PET could be improved by dynamic scan analysis combining D2R binding and regional tracer influx.
  67. ncbi Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
    David L Alexoff
    Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973 5000, USA
    J Nucl Med 44:815-22. 2003
    ..Here we investigate the reproducibility of microPET imaging of (11)C-raclopride in the rat brain and the effects of tracer-specific activity and photon scatter correction on measures of D2 ..
  68. pmc Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study
    Alice Egerton
    Psychiatric Imaging, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Neuroimage 50:260-6. 2010
    ..The effects of bupropion on extracellular dopamine levels in the striatum were investigated using [(11)C]raclopride positron emission tomography (PET) imaging in rats administered saline, 11 or 25 mg/kg bupropion i.p...
  69. ncbi Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..PET studies using [(11)C]raclopride and L-[beta-(11)C]DOPA were performed under resting condition and oral administration of single dose of the ..
  70. ncbi Nicotine-induced dopamine release in primates measured with [11C]raclopride PET
    Stefano Marenco
    Clinical Brain Disorders Branch, IRP, NIMH, USA
    Neuropsychopharmacology 29:259-68. 2004
    ..v. nicotine doses ranging from 0.01 to 0.06 mg/kg. [(11)C]raclopride was administered with either a bolus plus constant infusion or with paired bolus injections...
  71. ncbi Raclopride studies of dopamine release: dependence on presynaptic integrity
    Doris J Doudet
    Department of Medicine, Division of Neurology and Pacific Parkinson Research Center and TRIUMF DJD, University of British Columbia, Vancouver, British Columbia, Canada
    Biol Psychiatry 54:1193-9. 2003
    b>Raclopride and dopamine (DA) compete for in vivo binding to the D(2) receptors. Thus, measurements of raclopride binding provide a method to evaluate endogenous release in a variety of conditions...
  72. ncbi The use of healthy volunteers instead of patients to inform drug dosing studies: a [¹¹C]raclopride PET study
    Euitae Kim
    Department of Psychiatry, Seoul National University College of Medicine, 28 Yeongon dong, Chongno Gu, Seoul 110 744, South Korea
    Psychopharmacology (Berl) 217:515-23. 2011
    ....
  73. ncbi Differential effects of dopamine antagonists on locomotor activity, conditioned activity and conditioned place preference induced by cocaine in rats
    J U Adams
    Department of Psychiatry, New York University School of Medicine, Research Service, New York Harbor VA Health Care System, New York 10010, USA
    Behav Pharmacol 12:603-11. 2001
    ..Antagonists (haloperidol, raclopride and SCH23390; 0.03-0.1 mg/kg) were given only on test days for conditioned effects...
  74. ncbi Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride
    Jens C Pruessner
    McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    J Neurosci 24:2825-31. 2004
    ..end of the parental care distribution were then invited for a positron emission tomography study using [11C]raclopride and a psychosocial stress task...
  75. ncbi Raclopride-induced motor consolidation impairment in primates: role of the dopamine type-2 receptor in movement chunking into integrated sequences
    M Levesque
    Department of Psychology, Neuropsychology Division, University of Quebec in Montreal UQAM, PO Box 8888, Downtown Station, Montreal, Canada
    Exp Brain Res 182:499-508. 2007
    ..We therefore hypothesized that a D(2)R blocking substance, such as raclopride, would affect motor learning by specifically disrupting the grouping of movements into sequences...
  76. ncbi The effects of aging on dopaminergic neurotransmission: a microPET study of [11C]-raclopride binding in the aged rodent brain
    E Hoekzema
    Department de Psiquiatria i Medicina Legal, Universitat Autonoma de Barcelona, 08192, Bellaterra, Barcelona, Spain
    Neuroscience 171:1283-6. 2010
    ..effects can be discerned in rat brains, using in vivo molecular imaging with the radioactive compound [(11)C]-raclopride. We observed a robust decline in striatal [(11)C]-raclopride uptake in the aged rats in comparison to the young ..
  77. ncbi The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study
    Andrew J Montgomery
    MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, London W12 0NN, United Kingdom
    Synapse 61:637-45. 2007
    ..A recent PET study assessing the effect of smoking in humans showed no change in [(11)C]raclopride binding in the brain, but did find that "hedonia" correlated with a reduction in [(11)C]raclopride binding ..
  78. ncbi Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 63:1-6. 2009
    ..has been measured in several studies using positron emission tomography (PET) and the radiotracer [11C]-raclopride as a method for the in vivo imaging of serotonin modulation of striatal dopamine in human subjects...
  79. pmc Design and implementation of an automated partial volume correction in PET: application to dopamine receptor quantification in the normal human striatum
    Olivier G Rousset
    Section of High Resolution Brain PET Imaging, Division of Nuclear Medicine, Russell H Morgan Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Nucl Med 49:1097-106. 2008
    ....
  80. pmc Therapeutic application of transcranial magnetic stimulation in Parkinson's disease: the contribution of expectation
    Antonio P Strafella
    Montreal Neurological Institute, Neurology and Neurosurgery Dept, McGill University, 3801 University St, Montreal, QC, Canada H3A 2B4
    Neuroimage 31:1666-72. 2006
    ..from rTMS, which actually was delivered only as sham rTMS (placebo-rTMS) induced changes in striatal [11C] raclopride binding potentials (BP) as measured with positron emission tomography (PET)...
  81. pmc Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions
    K J Wong
    The Pennsylvania State University, Nutritional Sciences Dept, 110 Chandlee Laboratory, University Park, PA 16802, USA
    Pharmacol Biochem Behav 92:528-36. 2009
    This study assessed the effects of the opioid antagonist naltrexone, the dopamine 2-like (D2) antagonist raclopride, and the GABA(B) agonist baclofen on consumption of fat/sucrose mixtures (FSM) using a limited access protocol...
  82. ncbi Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA
    Sjoerd J Finnema
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden
    Synapse 63:378-89. 2009
    ..A total of 36 PET measurements were performed with the D(2/3) antagonist [11C]raclopride or the D(2/3) agonist [11C]MNPA in two cynomolgus monkeys...
  83. ncbi Test-retest reliability of central [11C]raclopride binding at high D2 receptor occupancy. A PET study in haloperidol-treated patients
    S Nyberg
    Karolinska Institute, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
    Psychiatry Res 67:163-71. 1996
    ..The calculation of D2 receptor occupancy using [11C]raclopride is routinely based on a ratio-equilibrium analysis, in which the ratio of radioactivity concentration in the ..
  84. ncbi Competition between 11C-raclopride and endogenous dopamine in Parkinson's disease
    Kenji Ishibashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Nucl Med Commun 31:159-66. 2010
    The aim of this study was to understand whether the increase in 11C-raclopride binding in the striatum of patients with Parkinson's disease (PD) is associated with the depletion of endogenous dopamine.
  85. ncbi Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil
    Wei Min Qu
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 28:8462-9. 2008
    ..at 30 microg/kg or D(2)R antagonist raclopride at 2 mg/kg blocked the arousal effects of low-dose modafinil at 22.5 and 45 mg/kg...
  86. ncbi Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia
    S Kapur
    The Clarke Institute of Psychiatry, Department of Psychiatry, University of Toronto, ON, Canada
    Am J Psychiatry 156:286-93. 1999
    ..The purpose of this study was to compare the D2 and serotonin 5-HT2 receptor occupancies of these drugs in patients receiving multiple-dose, steady-state regimens...
  87. ncbi Dopamine transmission in the human striatum during monetary reward tasks
    David H Zald
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37212, USA
    J Neurosci 24:4105-12. 2004
    Previous studies have demonstrated the ability of the [11C]raclopride positron emission tomography (PET) technique to measure behaviorally induced changes in endogenous dopamine transmission in humans...
  88. ncbi Impact of scatter correction on D2 receptor occupancy measurements using 123I-IBZM SPECT: comparison to 11C-Raclopride PET
    S Bullich
    Neurosciences Imaging Group, Molecular Imaging Centre CRC CIM, Barcelona Biomedical Research Park, C Dr Aiguader 88, soterrani 1, 08003 Barcelona, Spain
    Neuroimage 50:1511-8. 2010
    ..RO) achieved by antipsychotic drugs tend to be lower when measured with (123)I-IBZM SPECT than with (11)C-Raclopride PET...
  89. ncbi Decreasing amphetamine-induced dopamine release by acute phenylalanine/tyrosine depletion: A PET/[11C]raclopride study in healthy men
    Marco Leyton
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Neuropsychopharmacology 29:427-32. 2004
    ..reduce stimulated dopamine (DA) release, as assessed by positron emission tomography (PET) and changes in [(11)C]raclopride binding potential (BP), a measure of DA D2/D3 receptor availability...
  90. ncbi Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: striatal dopamine D2 receptor status investigated by [11C]raclopride positron emission tomography
    Matthias Reimold
    Department of Nuclear Medicine, University of Tubingen, Germany
    Mov Disord 21:1667-73. 2006
    ..dopaminergic function in SCA1, 2, and 3, dopamine D(2) receptor binding potential (BP) was assessed by [(11)C]raclopride positron emission tomography in 10 SCA patients, 4 of whom suffered from RLS as demonstrated by polysomnography...
  91. ncbi Dopamine release during sequential finger movements in health and Parkinson's disease: a PET study
    Ines K Goerendt
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Brain 126:312-25. 2003
    ..The objective of this study was to investigate in vivo, with [(11)C]raclopride, PET changes in regional brain levels of dopamine in healthy volunteers and Parkinson's disease patients during ..
  92. pmc High fat diet and food restriction differentially modify the behavioral effects of quinpirole and raclopride in rats
    Michelle G Baladi
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Eur J Pharmacol 610:55-60. 2009
    ..Free access to high fat chow increased sensitivity to quinpirole-induced yawning without changing sensitivity to raclopride-induced catalepsy or quinpirole-induced hypothermia...
  93. ncbi Quetiapine: an effective antipsychotic in first-episode schizophrenia despite only transiently high dopamine-2 receptor blockade
    Sitra Tauscher-Wisniewski
    Schizophrenia and Continuing Care Program, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Canada
    J Clin Psychiatry 63:992-7. 2002
    ..We treated patients experiencing their first episode of schizophrenia with a single daily dose of quetiapine to achieve a transient daily peak of D(2) receptor blockade, to determine if this would lead to an antipsychotic response...
  94. pmc Corticostriatal functional interactions in Parkinson's disease: a rTMS/[11C]raclopride PET study
    Antonio P Strafella
    Montreal Neurological Institute, Neurology and Neurosurgery Department, McGill University, 3801 University St, Montreal, QC H3A 2B4, Canada
    Eur J Neurosci 22:2946-52. 2005
    ..In the present study, using [11C]raclopride PET, we sought to investigate early PD patients with evidence of unilateral motor symptoms...
  95. ncbi In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..was assessed with PET in baboons and compared to that of the reference D2 receptor antagonist radiotracer [11C]raclopride. Three male baboons were studied with [11C]raclopride and [11C]NPA under baseline conditions and following ..
  96. ncbi D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]-MNPA, [3H]-(+)-PHNO, and [3H]-raclopride
    Teng Peng
    Department of Neuroscience, CNS Discovery, AstraZeneca, Wilmington, DE 19850, USA
    Synapse 64:624-33. 2010
    Positron emission tomography (PET) antagonist ligands such as [(11)C]-raclopride are commonly used to study dopamine D2 receptor (D2) binding of antipsychotics...
  97. ncbi Striatal dopamine release induced by repetitive transcranial magnetic stimulation of the human motor cortex
    Antonio P Strafella
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Brain 126:2609-15. 2003
    ..Using the same experimental approach, we sought to confirm this hypothesis. We used [11C]raclopride and PET to measure changes in extracellular dopamine concentration following rTMS of the motor cortex in six ..
  98. ncbi Enhanced cortical dopamine output and antipsychotic-like effect of raclopride with adjunctive low-dose L-dopa
    Amani Eltayb
    Department of Physiology and Pharmacology, Section of Neuropsychopharmacology, Karolinska Institutet, Stockholm, Sweden
    Biol Psychiatry 58:337-43. 2005
    ....
  99. ncbi Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat
    Alice Egerton
    Division of Neuroscience and Psychological Medicine, Department of Neuroscience and Mental Health, Imperial College London, London, W12 0NN, UK
    Psychopharmacology (Berl) 200:487-96. 2008
    ..However, it is not known whether 5-HT2A/2C receptor-mediated modulation of DA release can be quantified with non-invasive neurochemical imaging, as would be required for investigation of these processes in man...
  100. ncbi Endogenous dopamine release induced by repetitive transcranial magnetic stimulation over the primary motor cortex: an [11C]raclopride positron emission tomography study in anesthetized macaque monkeys
    Takashi Ohnishi
    Department of Investigative Radiology, National Cardio Vascular Center Research Institute, Osaka, Japan
    Biol Psychiatry 55:484-9. 2004
    ....
  101. ncbi Biodistribution and radiation dosimetry of the dopamine D2 ligand 11C-raclopride determined from human whole-body PET
    Mark Slifstein
    Department of Psychiatry, Columbia University, New York, New York 10032, USA
    J Nucl Med 47:313-9. 2006
    Whole-body radiation dosimetry of 11C-raclopride was performed in healthy human volunteers.

Research Grants65

  1. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..To do this, we aim to use functional magnetic resonance imaging (fMRI) and [11C]raclopride Positron Emission Tomography (PET) during a physiological challenge (monetary reward task) and a pharmacological ..
  2. Monoamine Contributions to Neurocircuitry in Eating Disorders
    Walter H Kaye; Fiscal Year: 2013
    ..with radioligands for the serotonin (5-HT) transporter ([11C]DASB) and dopamine (DA) D2/D3 receptors ([11C]raclopride)...
  3. Cytokine Effects on Amphetamine-Induced Dopamine Release using PET Neuroimaging
    Jennifer C Felger; Fiscal Year: 2011
    ..To test the hypothesis, [11C]raclopride neuroimaging with intravenous AMPH challenge will be used to indirectly measure DA availability and release ..
  4. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
    ..g., 11C-raclopride, 11C-altropane), as well...
  5. ROLE OF DOPAMINE RECEPTORS IN PRIMARY FOCAL DYSTONIAS
    Morvarid Karimi; Fiscal Year: 2013
    ..Other studies have found reduced raclopride uptake, which has a low selectivity for 5-HT(2A) but near equal selectivity for D2 and D3 receptors...
  6. Endotoxin-induced inflammation affects striatal dopamine: A raclopride PET study
    Evan D Morris; Fiscal Year: 2013
    ..In a cross-over, random-order, double-blind study, we will use positron emission tomography (PET) and [C-11]raclopride to measure methylphenidate-induced release of dopamine in the striatum in 10 healthy subjects...
  7. CENTRAL DOPAMINE RECEPTORS IN OBESITY
    TAMARA G HERSHEY; Fiscal Year: 2013
    ..in humans have been confounded by potential differences in endogenous dopamine release since the PET ligand (raclopride) used is known to be displaceable from receptors by endogenous dopamine...
  8. Imaging the causes and consequences of adolescent inhalant abuse
    Wynne K Schiffer; Fiscal Year: 2013
    ..Using Positron Emission Tomography (PET) and [11C]-raclopride, we will determine changes in dopamine release in response to an acute, rewarding dose of inhaled toluene...
  9. Probing dopamine D2 receptor trafficking in schizophrenia
    Anissa Abi-Dargham; Fiscal Year: 2013
    ..We propose to image 15 patients with schizophrenia and 15 healthy controls with PET, [11C]raclopride, at baseline, 3 h, and 8 h after amphetamine challenge (0.5 mg/kg, PO)...
  10. Optimal Dosing of Antipsychotic Drugs in Late Life
    David Mamo; Fiscal Year: 2013
    ..25 - 3.5 mg/day. A [11C]raclopride PET scan will be completed at baseline and after dose reduction...
  11. Dopamine Neurotransmission in Tourette Syndrome
    Rajendra D Badgaiyan; Fiscal Year: 2013
    ..extrastriatal areas will be estimated by estimating the binding potentials (BP) of dopamine receptor ligands 11C-raclopride and 18F-fallypride respectively at rest...
  12. Imaging varenicline effects on nicotine & dopamine: Gene modulation
    Gary S Wand; Fiscal Year: 2010
    ..will undergo a behavioral laboratory nicotine administration procedure followed by measurement of change in raclopride BP induced by smoking a nicotinized compared to a denicotinized cigarette...
  13. Dopamine and Unpredicted Alcohol Delivery: Effects of Alcohol Consumption
    Karmen K Yoder; Fiscal Year: 2013
    ..Changes in striatal DA levels will be detected using PET scanning and [11C]raclopride, a DA D2/D3 receptor ligand that is sensitive to changes in endogenous dopamine levels...
  14. Bulimia nervosa and dopamine: a link to addictions?
    Allegra I Broft; Fiscal Year: 2012
    ..Patients and controls will undergo 2 PET scans with [11C]raclopride, pre/post pharmacological challenge with methylphenidate, for the measurement of striatal DA type 2 (D2) ..
  15. Imaging the Neurobiology of a Behavioral Treatment for Cocaine Dependence
    DIANA M MARTINEZ; Fiscal Year: 2013
    ..Using Positron Emission Tomography (PET) and the radiotracer [11C]raclopride, we measured both D2/3 receptor binding potential (BPND) and stimulant-induced [11C]raclopride displacement ([..
  16. Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic Levels
    Jon Kar Zubieta; Fiscal Year: 2013
    ..We will employ the selective radiotracers [11C]carfentanil and [11C]raclopride and positron emission tomography for the non-invasive quantification of dopamine D2/3 and 5- opioid receptors...
  17. Ventrostriatal Dopamine Release and Reward Motivation in MDD
    Franklin R Schneier; Fiscal Year: 2013
    ..n=27) and healthy comparison (HC) subjects (n=27) will complete testing for DA release in the VST using [11C]raclopride PET pre- and post-amphetamine, and they will be assessed for reward learning using a probabilistic reward task...
  18. Cortical and Striatal Dopamine Dysfunction in Addiction and Schizophrenia
    Anissa Abi-Dargham; Fiscal Year: 2013
    ..will use the high-resolution Positron Emission Tomography (PET) camera ECAT EXACT HR+, D2 radiotracers, [11C]raclopride (SA1 and 2) and the amphetamine paradigm to measure stimulated dopamine release in three groups of subjects: ..
  19. Imaging Research on Impulsivity, Stress and Drug Abuse
    Lynn M Oswald; Fiscal Year: 2012
    ..Participants will complete a laboratory performance assessment of risk taking behavior and two [11C]raclopride PET scans measuring individual differences in amphetamine-induced DA release...
  20. A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
    Frances Rudnick Levin; Fiscal Year: 2013
    ..Our research group has demonstrated that deficient dopamine transmission, measured with the PET 11C-raclopride displacement paradigm, predicts poor response to a behavioral treatment program that included contingency ..
  21. PET RADIOTRACERS FOR IMAGING THE DOPAMINE D3 RECEPTOR
    Robert H Mach; Fiscal Year: 2013
    ..For example, [11C] raclopride, [18F] fallypride and [11C] PHNO bind with high affinity to dopamine D2 and D3 receptors...
  22. Dopaminergic Function in Alcoholism
    David A Kareken; Fiscal Year: 2013
    ..We will do this using positron emission tomography (PET) and the dopamine D2 ligand [11C]raclopride. Behavioral paradigms will be employed to study how alcohol administration, alcohol's cues, and ..
  23. NEW CNS DOPAMINE RECEPTOR IMAGING AGENTS
    HANK KUNG; Fiscal Year: 2002
    ..feasible to prepare Tc-99m labeled "benzamide" derivatives with similar biological properties to those of [11C]raclopride and [123I]IBZM, the most commonly used D2/D3 dopamine receptor imaging agents...
  24. Imaging dopamine transmission in comorbid schizophrenia and cannabis dependence
    Anissa Abi Dargham; Fiscal Year: 2009
    ..Twelve DD patients and 12 matched healthy controls (HC) will undergo PET imaging with [11C]raclopride and the D-amphetamine challenge...
  25. NEUROLEPTIC-INDUCED DYSKINESIAS AND DYSTONIAS
    Gaylord Ellison; Fiscal Year: 1992
    ..While "atypical" neuroleptics (clozapine and raclopride) do not induce these syndromes, with clozapine it seems that the TD-like profile gradually develops but its ..
  26. Dopamine, prediction error, and human alcohol consumption
    KARMEN YODER; Fiscal Year: 2009
    ..Changes in striatal DA levels will be detected using PET scanning and [11C]raclopride, a DA D2 receptor ligand that is sensitive to changes in endogenous dopamine levels...
  27. D2 RECEPTORS IN SCHIZOPHRENIA: OPTIMIZED PET LIGANDS
    Robert Kessler; Fiscal Year: 1993
    ..The ligands which are presently used in PET studies of the D2 receptor, i.e. spiperone or raclopride,are unsuitable for studies of limbic or cortical receptors...
  28. STATE OF THE ART PET SCANNER FOR MEDICAL RESEARCH
    Marc Laruelle; Fiscal Year: 1999
    ..and [11C]palmitate for heart studies, and numerus neuroreceptor probes for brain studies, such as [11C]raclopride (dopamine D2 receptors), [11C]NNC 112 {dopamine D1 receptors), [11C]WAY 100635 (serotonin 5HT1A receptors), and [..
  29. Imaging dopamine-2 (D2) receptor sites in schizophrenia
    Rajesh Narendran; Fiscal Year: 2009
    ..supported by the observation in three studies that the amphetamine-induced reduction in [123[] IBZM and [11C]raclopride binding potential (BP) was elevated in patients with schizophrenia...
  30. Imaging of dopamine function in schizophrenia
    Marc Laruelle; Fiscal Year: 2005
    ..Using [llC]raclopride and high resolution PET, we recently demonstrated the reliability of measuring DA transmission within the limbic,..
  31. Probing D2 receptor in vivo
    Dah Ren Hwang; Fiscal Year: 2003
    ..supported by three studies, which demonstrated that the amphetamine-induced reduction in [123I] IBZM or [11C] raclopride binding potential (BP) is elevated in patients with schizophrenia...
  32. DRUGS OF ABUSE AND NEGATIVE REINFORCEMENT
    JOSEPH GALIZIO; Fiscal Year: 1993
    ..and by drugs that affect specific receptor sites in the dopaminergic systems such as SCH23390, SKF38393, raclopride, and quinpirole...
  33. Dynamic control of dopamine release in cocaine abuse
    Paul Phillips; Fiscal Year: 2006
    ..If it is then more selective antagonists (SCH-23390 and raclopride) will be used to determine whether the transmission is via D1-like or D2-like receptors...
  34. PET in Obese Monkeys: A Developmental (R21) Application
    Gene Jack Wang; Fiscal Year: 2005
    ..obese subjects (BMI > 40 kg/m2), using positron emission tomography (PET) and the radioligand [11C]raclopride. Obese subjects also had higher rates of glucose metabolism in dopamine projection areas than the control ..
  35. Imaging Ventrostriatal Dopamine System in Cocaine Abuse
    Marc Laruelle; Fiscal Year: 2004
    ..data, we probed the responsivity of DA neurons to an amphetamine challenge, by measuring the decrease in [11C]raclopride binding potential resulting from the increase in synaptic DA induced by amphetamine...
  36. Imaging Dopamine D2 Agonist Binding Sites in Cocaine Dependence with [11C]NPA
    Rajesh Narendran; Fiscal Year: 2010
    ..human subjects (CDS) have now reported a severe blunting (decrease) in the stimulant induced reduction in [11C]raclopride and [123I]IBZM in the striatum (and ventral striatum that includes the accumbens) (Malison et al...
  37. Brain Blood Flow Imaging of Cocaine Withdrawal&Craving
    ANNA CHILDRESS; Fiscal Year: 2004
    ..PET and a C-11 raclopride competition paradigm are used to infer changes in endogenous DA. As in Aim 2, baclofen (vs...
  38. ESTIMATION OF SYNAPTIC DOPAMINE USING PET AND SPECT
    SAMUEL GATLEY; Fiscal Year: 2001
    DESCRIPTION: Binding of dopamine D2 PET and SPECT radioligands including [C-11] raclopride and [I-123]IBZM in vivo is affected by competition with endogenous dopamine...
  39. DOPAMINE TRANSMISSION IN ALCOHOLISM
    Anissa Abi Dargham; Fiscal Year: 2002
    ..D2 receptors's availability will be measured as the binding potential of the radiotracer [~ ~C]raclopride. The amphetamine-induced intrasynaptic DA release will be evaluated by the displacement of [~C]raclopride from ..
  40. Dopamine D3 Receptor Imaging Agents for PET and SPECT
    Robert Mach; Fiscal Year: 2006
    ..For example, [11C]raclopride and [123I]IBZM bind with high affinity to dopamine D2 and D3 receptors, and [11C/18F]N-methylspiperone binds ..
  41. LIGANDS FOR CEREBRAL DOPAMINERGIC STUDIES BY PET & SPECT
    STEPHEN MOERLEIN; Fiscal Year: 1993
    ..New high-specific activity 18F- and 123I-labeled analogues of the D-2 ligand raclopride, the D-1 ligand SCH-23390, and the presynaptic dopamine transport antagonist GBR-12935 will be synthesized for ..
  42. Brain Dopamine Function in Adults with ADHD
    Gene Jack Wang; Fiscal Year: 2007
    ..11C]cocaine (DAT radioligand) and to assess DA cell function using the dopamine D2 receptor radioligand [11C]raclopride with and without a challenge dose of methylphenidate (drug that increases DA by blocking DAT)...
  43. DOPAMINERGIC BRAIN FUNCTION IN ALCOHOLICS
    Gene Jack Wang; Fiscal Year: 2007
    ..unreadable] To test these hypotheses we will use PET to measure D2-R availability using [11C] raclopride and to measure regional brain glucose metabolism using 18FDG at baseline and during alcohol intoxication (0...
  44. Pet Imaging of Extrastriatial Dopamine Levels
    Robert Kessler; Fiscal Year: 2005
    ..This dose of real d-amphetamine produces decrements in striatal [11C] raclopride binding potentials similar to those seen with a 0.2-0...
  45. PET STUDIES OF CHOLINERGIC MODULATION IN ALZHEIMERS
    Gwenn Smith; Fiscal Year: 2000
    ..cholinegic antagonist scopolamine) will be used with PET and radiotracers for dopaminergic (D2, [1]C]- raclopride) and serotonergic (5-HT2A, [18F]-altanserin) receptors...
  46. Nicotine-Induced Dopamine Changes In Addicted Smokers
    Mark Mintun; Fiscal Year: 2003
    ..Sensitivity to nicotine-induced dopamine release will be optimized by the use of 3D PET acquisition, higher raclopride dose (0...
  47. PET Studies of Brain Dopamine in Stimulant Abusers
    Gene Jack Wang; Fiscal Year: 2007
    ..measure DAT using [ C]cocaine (DAT radioligand) and to assess DA cell function by comparing the binding of [nC]raclopride (IDA D2 radioligand whose binding to D2 receptors is sensitive to competition by endogenous DA) with and without ..
  48. Simultaneous PET imaging of rCBF and dopamine release
    ALEXANDER CONVERSE; Fiscal Year: 2006
    ..blood flow tracer, [17F]fluoromethane (t1/2 = 65 s), in the presence of a long lived neurochemical tracer, [11C]raclopride (t1/2 = 20 min)...
  49. PET INVESTIGATIONS OF NEUROTRANSMITTER INTERACTIONS
    STEPHEN DEWEY; Fiscal Year: 1999
    ..These studies will use C-11 raclopride (RAC), a D2/D3 receptor antagonist, to image postsynaptic dopamine receptors and a new ligand, C-11 SR46349B, a ..
  50. 11C-N-METHYLSPIPERONE PET SCANNING IN SCHIZOPHRENIA
    Larry Tune; Fiscal Year: 1993
    ..using both PET methods (ie, that of Wong, et al, and Farde, et al) and ligands (11-C-N-methylspiperone and raclopride) to resolve the controversy over dopamine-2 receptor Bmax estimates in drug-naive schizophrenic brains...
  51. Neurochemical and Behavioral Alterations in Reward
    NICOLE BARBARICH MARSTELLER; Fiscal Year: 2006
    ..Second, I will use 11 C-raclopride and microPET, in combination with AMPT, to measure changes in D2 receptor number induced by chronic food ..
  52. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..The study will use PET and |' lC]raclopride with a psychostimulant challenge in order to measure baseline D2 receptor availability and amphetamine-induced ..
  53. Neurochemistry of Nicotine Dependence in Schizophrenia
    Wynne Schiffer; Fiscal Year: 2004
    ..Or increase inhibitory activity with the GABA agonist, gamma-vinyl GABA, prior to the nicotine challenge. We hope to guide the development of novel therapies for dual-diagnosis schizophrenia. ..
  54. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  55. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  56. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Dopamine mechanisms in development of type-2 diabetes
    Andras Hajnal; Fiscal Year: 2008
    ..These studies will help determine how plasticity in the dopaminergic system affects behavioral and metabolic factors related to hyperphagia and the development of dietary-induced NIDDM. ..
  58. GUSTATORY REWARD AND DOPAMINE IN THE NUCLEUS ACCUMBENS
    Andras Hajnal; Fiscal Year: 2003
    ..This knowledge is directly relevant to understanding the control of normal ingestive behavior and to the maladies related to this essential behavior, such as obesity, anorexia nervosa, bulimia nervosa, and binge eating disorder. ..
  59. BASAL GANGLIA CIRCUITRY IMMEDIATE EARLY GENE EXPRESSION
    David Wirtshafter; Fiscal Year: 2003
    ..Other studies will examine the effects of lesions within the basal ganglia on the IEG expression induced by systemic administration of dopaminergic drugs. ..
  60. IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVING
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
  61. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  62. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  63. DOPAMINE AND GABA IMAGING IN SCHIZOPHRENIA
    Lawrence Kegeles; Fiscal Year: 2004
    ..abstract_text> ..