iodohippuric acid

Summary

Summary: An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.

Top Publications

  1. ncbi Unilateral ureteropelvic junction obstruction in children: long-term followup after unilateral pyeloplasty
    Ariane Boubaker
    Nuclear Medicine Department, University Hospital, Lausanne, Switzerland
    J Urol 170:575-9; discussion 579. 2003
  2. ncbi Renal insufficiency in patients with hematologic malignancies undergoing total body irradiation and bone marrow transplantation: a prospective assessment
    Raymond Miralbell
    University Hospital of Geneva, Geneva, Switzerland
    Int J Radiat Oncol Biol Phys 58:809-16. 2004
  3. ncbi Excision of the dilated pelvis is not necessary in laparoscopic dismembered pyeloplasty
    M Reismann
    Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany
    Eur J Pediatr Surg 18:19-21. 2008
  4. ncbi 99mTc-MAEC complexes: new renal radiopharmaceuticals combining characteristics of (99m)Tc-MAG3 and (99m)Tc-EC
    Andrew T Taylor
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Nucl Med 45:885-91. 2004
  5. pmc Renal 131I-hippuran extraction in man: effects of dopamine
    M Hutchings
    Department of Neuroanaesthesia, The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Denmark
    Br J Clin Pharmacol 54:675-7. 2002
  6. ncbi Evaluation of renal graft haemodynamia by 51Cr-EDTA and o-[131I]iodohippurate: its use in the early diagnosis of glomerular hyperfiltration
    M Estorch
    Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Nucl Med Commun 24:679-82. 2003
  7. ncbi Technetium-99m DTPA dimethyl ester: a renal function imaging agent. Comparative studies in animals with technetium-99m mercaptoacetyl triglycine and 131I-ortho-iodohippurate
    K Bhowal
    Nuclear Medicine Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Nucl Med Commun 24:583-95. 2003
  8. ncbi 123I-hippuran renal scintigraphy with evaluation of single-kidney clearance for predicting renal scarring after acute urinary tract infection: comparison with (99m)Tc-DMSA scanning
    Alessio Imperiale
    Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Nucl Med 44:1755-60. 2003
  9. ncbi Renal function and cardiopulmonary bypass in pediatric cardiac surgical patients
    Guillermo Lema
    Department of Anaesthesiology, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Pediatr Nephrol 21:1446-51. 2006
  10. ncbi Reassessment of the reproducibility of Technetium-99m mercaptoacetyltriglycine clearance
    Carlos De Sadeleer
    Department of Radioisotopes, C H U Saint Pierre Brussels, Belgium
    Nucl Med Rev Cent East Eur 8:15-20. 2005

Research Grants

  1. Decision Support Systems for MAG3 Renography
    Andrew Taylor; Fiscal Year: 2005
  2. DEVELOPMENT OF TC-99M RENAL TUBULAR AGENTS
    Andrew Taylor; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications139 found, 100 shown here

  1. ncbi Unilateral ureteropelvic junction obstruction in children: long-term followup after unilateral pyeloplasty
    Ariane Boubaker
    Nuclear Medicine Department, University Hospital, Lausanne, Switzerland
    J Urol 170:575-9; discussion 579. 2003
    ..The benefit of surgery on renal function in unilateral ureteropelvic junction stenosis (UPJS) is still debated. We evaluated renal function outcome after unilateral pyeloplasty in 53 children...
  2. ncbi Renal insufficiency in patients with hematologic malignancies undergoing total body irradiation and bone marrow transplantation: a prospective assessment
    Raymond Miralbell
    University Hospital of Geneva, Geneva, Switzerland
    Int J Radiat Oncol Biol Phys 58:809-16. 2004
    ..A study was undertaken to assess prospectively the subclinical renal function changes with radioisotopic methods in patients undergoing BMT for hematologic malignancies...
  3. ncbi Excision of the dilated pelvis is not necessary in laparoscopic dismembered pyeloplasty
    M Reismann
    Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany
    Eur J Pediatr Surg 18:19-21. 2008
    ..We compared the treatment results of both techniques to investigate whether extensive resection is necessary or not in dismembered pyeloplasty procedures...
  4. ncbi 99mTc-MAEC complexes: new renal radiopharmaceuticals combining characteristics of (99m)Tc-MAG3 and (99m)Tc-EC
    Andrew T Taylor
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Nucl Med 45:885-91. 2004
    ....
  5. pmc Renal 131I-hippuran extraction in man: effects of dopamine
    M Hutchings
    Department of Neuroanaesthesia, The Neuroscience Centre, Copenhagen University Hospital Rigshospitalet, Denmark
    Br J Clin Pharmacol 54:675-7. 2002
    ..This study examined the 131I-hippuran extraction fraction during baseline renal blood flow rates and at high flow rates induced by dopamine...
  6. ncbi Evaluation of renal graft haemodynamia by 51Cr-EDTA and o-[131I]iodohippurate: its use in the early diagnosis of glomerular hyperfiltration
    M Estorch
    Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Nucl Med Commun 24:679-82. 2003
    ..min-1 (P=0.002) respectively. It is concluded that determinations of GFR, ERPF, GFF and GCP allow non-invasive evaluation of renal graft haemodynamia and can be useful in the early detection of glomerular hyperfiltration...
  7. ncbi Technetium-99m DTPA dimethyl ester: a renal function imaging agent. Comparative studies in animals with technetium-99m mercaptoacetyl triglycine and 131I-ortho-iodohippurate
    K Bhowal
    Nuclear Medicine Division, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700032, India
    Nucl Med Commun 24:583-95. 2003
    ....
  8. ncbi 123I-hippuran renal scintigraphy with evaluation of single-kidney clearance for predicting renal scarring after acute urinary tract infection: comparison with (99m)Tc-DMSA scanning
    Alessio Imperiale
    Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Nucl Med 44:1755-60. 2003
    ..The value of (123)I-hippuran (OIH) renal sequential scintigraphy (RSS) in predicting the evolution of defects detected by (99m)Tc-dimercaptosuccinic acid (DMSA) scanning during a first episode of acute pyelonephritis (APN) was assessed...
  9. ncbi Renal function and cardiopulmonary bypass in pediatric cardiac surgical patients
    Guillermo Lema
    Department of Anaesthesiology, Pontificia Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Pediatr Nephrol 21:1446-51. 2006
    ..Minor increases of alpha GS-T in urine postoperatively did not confirm cellular tubular damage. There was no tubular dysfunction at that time...
  10. ncbi Reassessment of the reproducibility of Technetium-99m mercaptoacetyltriglycine clearance
    Carlos De Sadeleer
    Department of Radioisotopes, C H U Saint Pierre Brussels, Belgium
    Nucl Med Rev Cent East Eur 8:15-20. 2005
    ..Conflicting results have been published concerning the reproducibility of Tc-99m MAG3 clearance. The aim of the study was to reevaluate again this reproducibility on a large prospective series of healthy volunteers...
  11. ncbi In vitro system to estimate renal brush border enzyme-mediated cleavage of Peptide linkages for designing radiolabeled antibody fragments of low renal radioactivity levels
    Yasushi Fujioka
    Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Bioconjug Chem 16:1610-6. 2005
    ..in HML by the action of renal brush border enzymes, followed by urinary excretion of the resulting m-iodohippuric acid. In this study, an in vitro system using brush border membrane vesicles (BBMVs) isolated from the rat kidney ..
  12. ncbi A porcine model of systemic and renal haemodynamic responses to infrarenal aortic cross-clamping
    P Alric
    Service de Chirurgie Vasculaire, Hopital Arnaud de Villeneuve, Unité INSERM U 469, Faculte de Medecine, Universite Montpellier 1, 34295 Montpellier, France
    Eur J Vasc Endovasc Surg 25:72-8. 2003
    ..The main purpose of this study was to establish an animal model in which infrarenal AXC could reproduce similar systemic and renal haemodynamic changes to those observed in humans...
  13. ncbi The abnormal renal vasodilator response to D1-like receptor stimulation in conscious SHR can be normalized by AT1 blockade
    P A Marcel de Vries
    Departments of Clinical Pharmacology, Groningen University Institute for Drug Exploration GUIDE, State University, Groningen, The Netherlands
    J Cardiovasc Pharmacol 44:571-6. 2004
    ....
  14. ncbi Design, synthesis, and evaluation of [188Re]organorhenium-labeled antibody fragments with renal enzyme-cleavable linkage for low renal radioactivity levels
    Tomoya Uehara
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Bioconjug Chem 18:190-8. 2007
    ..low renal radioactivity levels even shortly after injection, due to a rapid and selective release of m-[131I]iodohippuric acid by the action of brush border enzymes...
  15. ncbi The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy
    E R Maccariello
    Hypertension Clinic of the Laboratory of Clinical and Experimental Pathophysiology-CLINEX, Rio de Janeiro State University, Brazil
    Am J Hypertens 10:541-5. 1997
    ..In conclusion, IS, SP and IS + SP were effective in reducing blood pressure while keeping renal function stable. Only SP significantly decreased UAE. Enhanced UKal may have played a role in natriuresis observed after IS and IS + SP...
  16. ncbi Urinary N-terminal prohormone brain natriuretic peptide excretion in patients with chronic heart failure
    Gerard C M Linssen
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circulation 120:35-41. 2009
    ..The clinical implications and the value of measurement of urinary NT-proBNP in patients with heart failure are largely unknown...
  17. pmc Initial evaluation of new 99mTc(CO)3 renal imaging agents having carboxyl-rich thioether ligands and chemical characterization of ReCO3 analogues
    Haiyang He
    Department of Radiology, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 34:709-16. 2007
    ..Once the ligand is bound to (99m)Tc(CO)(3) through a thioether and two carboxyl groups, the complexes have at least one unbound carboxyl group, essential for the interaction with the renal tubular transporter...
  18. ncbi Assessment of radiochemical design of antibodies using an ester bond as the metabolizable linkage: evaluation of maleimidoethyl 3-(tri-n-butylstannyl)hippurate as a radioiodination reagent of antibodies for diagnostic and therapeutic applications
    Y Arano
    Faculty of Pharmaceutical Sciences, Department of Radiopharmaceutical Sciences, Kyoto University, Japan
    Bioconjug Chem 7:628-37. 1996
    ..A new radioiodination reagent with an ester bond to liberate m-iodohippuric acid from covalently conjugated proteins, maleimidoethyl 3-(tri-n-butylstannyl)hippurate (MIH), was recently ..
  19. ncbi Relative glomerular hyperfiltration in primary aldosteronism
    Jean Ribstein
    Department of Medicine, Hopital Lapeyronie, 34295 Montpellier Cedex 5, France
    J Am Soc Nephrol 16:1320-5. 2005
    ..These data suggest that PA was associated with relative hyperfiltration, unmasked after suppression of aldosterone excess...
  20. ncbi Analysis of renal handling of radiopharmaceuticals
    F Trejtnar
    Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
    Q J Nucl Med 46:181-94. 2002
    ....
  21. ncbi Chemical design of radiolabeled antibody fragments for low renal radioactivity levels
    Y Arano
    Department of Patho Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Cancer Res 59:128-34. 1999
    ..Fab fragments were also radiolabeled by direct radioiodination (125I-Fab) or by conjugation with meta-[125I]-iodohippuric acid via an amide bond [N-(5-maleimidopentyl) 3'-iodohippuric acid amide ([125I]MPH-Fab)] or an ester bond [..
  22. ncbi Renal response to angiotensin II is blunted in sodium-sensitive normotensive men
    Folkert W Visser
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Hypertens 21:323-8. 2008
    ..The renal mechanisms of SS in normotensives are unknown. Therefore, we studied whether SS is related to renal hemodynamics and renal responsiveness to angiotensin II (AngII) in young healthy adults...
  23. ncbi The utility of 99mTc-mercaptoacetyltriglycine in captopril renography
    A Taylor
    Department of Radiology, Emory University Medical Center, Atlanta, Georgia 30322
    Am J Hypertens 4:731S-736S. 1991
    ..The optimal criteria for defining an abnormal study still need to be determined and then applied in a prospective study...
  24. ncbi Functional renal imaging: new trends in radiology and nuclear medicine
    Emmanuel Durand
    Biophysics and Nuclear Medicine, University Paris Sud, 78 rue du General Leclerc, Le Kremlin Bicetre Cedex, France
    Semin Nucl Med 41:61-72. 2011
    ..Other developments, such as diffusion or blood oxygen level-dependent imaging, may have a role in the future. The other modalities have a limited role in clinical practice for functional renal imaging...
  25. ncbi Compensatory changes in the function of the remaining kidney immediately after unilateral nephrectomy in sheep
    Gaber Ziada
    Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait
    Tohoku J Exp Med 219:165-8. 2009
    ..001). We conclude that after unilateral nephrectomy the remaining kidney immediately compensates for the loss of a donated kidney by increasing glomerular filtration rate and effective renal plasma flow...
  26. ncbi Technetium-99m labeled p-aminohippuric acid analogues: renal function agents
    Z Zhang
    Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461
    J Pharm Sci 78:829-32. 1989
    ..Further investigation is needed to determine if these derivatives may be used to replace [131I]o-iodohippuric acid for the evaluation of renal function.
  27. ncbi Synthesis and mass spectroscopy kinetics of a novel ternary copper(II) complex with cytotoxic activity against cancer cells
    M Barceló-Oliver
    Departament de Quimica, Grup de Química Bioinorgànica i Bioorgànica, IUNICS, Universitat de les Illes Balears, Campus UIB, Carretera Valldemossa Km 7 5, Palma de Mallorca E 07122, Spain
    J Inorg Biochem 101:649-59. 2007
    The X-ray structure of the [Cu(I-hip)(phen)2](+).(I-hip-).(H2O)7 complex (1) (where I-hipH is referred to o-iodohippuric acid and phen is 1,10-phenanthroline) and its binary synthetic intermediate [Cu(I-hip)2(H2O)3]...
  28. ncbi Technetium-99m labeled renal function and imaging agents: III. Synthesis of 99mTc-MAG3 and biodistribution of by-products
    W Brandau
    , Zentrum Radiologie
    Int J Rad Appl Instrum A 39:121-9. 1988
    99mTc-MAG3, a new 99mTc radiopharmaceutical with biological properties similar to o-iodohippuric acid (OIH), is expected to find wide clinical application for renal function studies...
  29. ncbi Clinical evaluation of technetium-99m-L,L-ethylenedicysteine in patients with chronic renal failure
    E M Prvulovich
    Institute of Nuclear Medicine, University College London Medical School, United Kingdom
    J Nucl Med 38:809-14. 1997
    ..This study evaluated 99mTc-L,L-EC in patients with chronic renal failure...
  30. ncbi [Procedure guidelines for dynamic renal scintigraphy]
    T Zajic
    Radiologische Universitatsklinik, Abt Nuklearmedizin, Hugstetterstr 55, 79106 Freiburg
    Nuklearmedizin 43:177-80. 2004
    ..Common clinical applications as well as a detailed description of the procedure are given. It also includes explanations and hints concerning the analysis, evaluation, interpretation, and presentation of the findings...
  31. ncbi Inhibition of cGMP-specific phosphodiesterase type 5 reduces sodium excretion and arterial blood pressure in patients with NaCl retention and ascites
    Helle C Thiesson
    Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
    Am J Physiol Renal Physiol 288:F1044-52. 2005
    ..In patients with ascites and cirrhosis, inhibition of PDE5 did not promote natriuresis but led to increased plasma levels of the renin-angiotensin-aldosterone system...
  32. ncbi Unilateral urinary flow impairment at the pelviureteral junction: outcome of renal function with respect to therapeutic strategy
    Ariane Boubaker
    Department of Nuclear Medicine, University Hospital, Lausanne, Switzerland
    Urology 61:1224-8; discussion 1228-9. 2003
    ..To evaluate the renal function outcome in children with unilateral hydronephrosis and urinary flow impairment at the pelviureteral junction with respect to the therapeutic strategy...
  33. ncbi Evaluation of effective renal plasma flow with I-127 ortho-iodohippurate and I-123 ortho-iodohippurate in rabbits
    G Mariani
    Department of Internal Medicine and Medical Specialties, University of Genoa Medical School, Italy
    Acad Radiol 7:705-10. 2000
    ..In this study, the authors assessed the potential of the new system to evaluate ERPF by using an iodinated contrast medium with adequate glomerular filtration and tubular secretion properties...
  34. ncbi The exercise renogram and its interpretation
    J H Clorius
    Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany
    J Nucl Med 38:1146-51. 1997
    ..The aim of this study was to demonstrate the interpretative approach and the terminology which is used to describe results of exercise renography, using a population of hypertensives with renovascular disease...
  35. ncbi Biodistribution and renal excretion of isomers of the cationic tracer, (99m)Tc diaminocyclohexane (DACH): biodistribution of cationic renal tracers
    A Taylor
    Department of Radiology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Nucl Med Biol 28:299-302. 2001
    ..Development of alternative cationic renal tracers is warranted...
  36. ncbi Technetium-99m-N,N-ethylenedicysteine--a comparative study of renal scintigraphy with technetium-99m-MAG3 and iodine-131-OIH in patients with obstructive renal disease
    K Ozker
    Department of Nuclear Medicine, Cerrahpasa Medical Faculty, Istanbul, Turkey
    J Nucl Med 35:840-5. 1994
    ..To evaluate the diagnostic characteristics of this agent, a gamma camera study was performed...
  37. ncbi Mapping of local renal blood flow with PET and H(2)(15)O
    Nathaniel M Alpert
    Division of Nuclear Medicine, Department of Radiology, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
    J Nucl Med 43:470-5. 2002
    ..We developed a noninvasive method for the mapping of regional renal blood flow in humans using PET and H(2)(15)O...
  38. ncbi [Endothelial dysfunction and cardiac performance in untreated hypertension]
    G du Cailar
    , , Montpellier
    Arch Mal Coeur Vaiss 89:979-82. 1996
    ..The link between these factors may be the endothelium which abnormal regulatory function secondary to aging and HT may be associated to an impairment of NO dependent LV relaxation...
  39. ncbi Functional effects of renal artery stent placement on treated and contralateral kidneys
    Trude C Leertouwer
    Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Kidney Int 62:574-9. 2002
    ..This study examined the effects of stent placement for renal artery stenosis on the function of treated and contralateral kidneys...
  40. ncbi Effective renal plasma flow response and atrial natriuretic peptide in patients with uncomplicated acute myocardial infarction
    C Y Chen
    Division of Cardiology, Veterans General Hospital Kaohsiung, Taiwan, Republic of China
    Jpn Heart J 34:1-10. 1993
    ..2, 65.6 +/- 20.8, 57.4 +/- 19.2 pg/ml, respectively). It was concluded that, in the presence of uncomplicated acute myocardial infarction, patients may show renal vasodilatation, and that the elevation of ANP may play some role in this...
  41. ncbi Clinical evaluation of 99mTc diaminocyclohexane, a renal tubular agent with cationic transport: results in healthy human volunteers
    A K Padhy
    Department of Nuclear Medicine, St Bartholomew s Hospital, London, UK
    Nephron 65:294-8. 1993
    ..001) in DACH clearance was noted, but hippuran clearance remained unaltered. The results support the hypothesis that 99mTc DACH is transported cationically...
  42. ncbi Usefulness of 99Tcm-N,N'-ethylene-1-dicysteine complex for dynamic kidney investigations
    M J Surma
    Department of Nuclear Medicine, Medical University of Lodz, Poland
    Nucl Med Commun 15:628-35. 1994
    ..245 x ClEC + 51.52. On the basis of this equation a lower boundary of the normal 99Tcm-EC clearance was established; it amounts to 300 ml min-1 1.73 m-2...
  43. ncbi Donor kidney adapts to body dimensions of recipient: no influence of donor gender on renal function after transplantation
    H Tent
    Internal Medicine Division of Nephrology Obstetrics and Gynecology Transplantation Immunology Surgery, University Medical Center Groningen, The Netherlands
    Am J Transplant 11:2173-80. 2011
    ..Kidneys adapt to the recipient's body size and demands, independent of gender, without detrimental effects in renal function and outcome up to mid-long term...
  44. ncbi A physiologic approach to renal scintigraphy. Application to evaluation of hypertension
    S Turpin
    Department of Nuclear Medicine, Hospital Hôtel Dieu de Montréal, Universite de Montreal, Quebec, Canada
    Clin Nucl Med 20:206-10. 1995
    ..6-2.0 ml/g/minute, GFR = 0.25-0.4 ml/g/minute, and filtration fraction (i.e., GFR/ERPF = 0.15-0.20) on the affected side...
  45. ncbi Comparison of single-injection multisample renal clearance methods with and without urine collection
    C D Russell
    Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233, USA
    J Nucl Med 36:603-6. 1995
    ..In this study, we compare urine-based and urine-free methods for the tubular agents 99mTc-MAG3 and 131I-OIH...
  46. ncbi Prediction of renal transplant survival from early postoperative radioisotope studies
    C D Russell
    University of Alabama Hospital and VA Medical Center, Birmingham 35233, USA
    J Nucl Med 41:1332-6. 2000
    ..We present here the correlation between baseline measurements and the 1-y graft survival...
  47. ncbi Comparison of standard and radionuclide methods for measurement of glomerular filtration rate and effective renal blood flow in female horses
    H K Matthews
    Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901
    Am J Vet Res 53:1612-6. 1992
    ..of the radiopharmaceuticals, 99mTc-labeled diethylene-triaminepentaacetic acid (99mTc-DTPA) and [131I]-o-iodohippuric acid (131I-OIH), respectively. Mean +/- SEM GFR, using inulin, was 1.83 +/- 0.21 ml/min/kg of body weight...
  48. ncbi Report of the Working Party Group on Determining the Radionuclide of Choice
    M D Blaufox
    Albert Einstein College of Medicine, Bronx, NY 10461
    Am J Hypertens 4:747S-748S. 1991
    ..Considerations of cost, ease of use, reliability, dosage, and the effects of different protocols were all examined...
  49. ncbi [Clinical evaluation of 123I-orthoiodohippurate (123I-OIH) for diagnosis of renal function: dose finding study]
    M Fukuchi
    Department of Nuclear Medicine, Hyogo College of Medicine
    Hinyokika Kiyo 36:197-205. 1990
    ..abstract truncated at 250 words)..
  50. ncbi A simple and accurate grading system for orthoiodohippurate renal scans in the assessment of post-transplant renal function
    S K Zaki
    Department of Urology, Cleveland Clinic Foundation, Ohio 44195
    J Urol 143:1099-102. 1990
    ..005) and need for hemodialysis (p = 0.007). We recommend this grading system as a simple and accurate method to interpret orthoiodohippurate renal scans in the evaluation and followup of renal allograft recipients...
  51. ncbi Diminished response to furosemide in I-123 Hippuran renal studies of renovascular hypertension caused by unilateral renal artery stenosis
    F M Flueckiger
    Department of Radiology, Division of Nuclear Medicine, Graz, Austria
    Clin Nucl Med 15:614-7. 1990
    ..It is concluded that the stimulation of diuresis with furosemide and its quantification represent an important additional step in the evaluation of dynamic I-123 Hippuran studies to detect renal ischemia...
  52. ncbi Measurement of renal blood flow by 131I-labelled sodium iodohippurate imaging in a rat model of herpes encephalitis
    G M Cleator
    Department of Medical Microbiology, Medical School, University of Manchester, England
    Acta Radiol 31:538-9. 1990
    ..Our data suggest that kidney function is not compromised in this animal model of encephalitis. The results are discussed in the context of the development of a non-invasive protocol for the in vivo diagnosis of herpes encephalitis...
  53. ncbi Effect of advanced age on p-aminohippurate-induced inhibition of renal tubular secretion in male Fischer 344 rats
    R E Galinsky
    Department of Pharmaceutics, University of Utah, Salt Lake City 84112
    Mech Ageing Dev 56:209-22. 1990
    ..Aging did not alter PAH-induced inhibition of iodohippurate secretion. Inhibition of MAG3 elimination was more pronounced in the old rats compared to the young controls...
  54. ncbi Decreased nitric oxide products in the urine of patients undergoing cardiac surgery
    Guillermo Lema
    Department of Anesthesiology, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Cardiothorac Vasc Anesth 23:188-94. 2009
    ..The objective of this study was to establish whether the release of the endothelial vasodilator nitric oxide (NO) or NO products is altered in patients undergoing surgery with cardiopulmonary bypass in 3 different clinical conditions...
  55. ncbi [Change of joint synovial clearance speed in experimental arthritis]
    M Yabuki
    Department of Orthopedic Surgery, Yokohama City University School of Medicine
    Ryumachi 31:4-13. 1991
    ....
  56. ncbi [The significance of a new radiopharmaceutic agent, 99mTc-mercaptoacetyltriglycine (MAG 3), in the diagnosis of diseases of the kidneys and urinary tract in children]
    J Lepej
    Klinika nukleárnej medicíny Lekárskej fakulty Univerzity Komenského, Martin
    Cesk Pediatr 45:134-7. 1990
    ..It is superior to hitherto used substances as regard the quality of visualization and in particular the lower radiation load. Therefore it is particularly suited for paediatric practice...
  57. ncbi Simplified methods for renal clearance in children: scaling for patient size
    C D Russell
    Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233
    J Nucl Med 32:1821-5. 1991
    ..Inclusion of pediatric data improves the fit and permits development of generic methods that work with both adults and children...
  58. ncbi The kidney: imaging with Tc-99m mercaptoacetyltriglycine, a technetium-labeled analog of iodohippurate
    C D Russell
    Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233
    Radiology 172:427-30. 1989
    ..The biological properties of the two agents were found to be so similar that conventional diagnostic criteria for I-131 OIH could be used for Tc-99m MAG3 with only minor modifications...
  59. ncbi Glomerular filtration and tubular secretion of MAG-3 in the rat kidney
    R Muller-Suur
    Karolinska Institute, Dept of Clinical Physiology Danderyds Hospital, Stockholm, Sweden
    J Nucl Med 30:1986-91. 1989
    ....
  60. ncbi Age-dependent enzymuria, proteinuria and changes in renal blood flow and glomerular filtration rate in rats
    G Casadevall
    Unitat de Fisiologia, Facultat de Farmacia, Universitat de Barcelona, Spain
    Mech Ageing Dev 82:51-60. 1995
    ..The present findings indicate that urinary markers of renal injury increase with age, whereas GFR and RBF only decrease when expressed as clearance related to body weight...
  61. ncbi 99mTc-MAG3: dynamic studies in patients with renal disease
    G H Schaap
    Department of Internal Medicine, Free University Hospital, Amsterdam, The Netherlands
    Eur J Nucl Med 14:28-31. 1988
    ..We conclude that in spite of a high renal clearance (ratio to 125I-OT clearance 2.69 +/- 0.27), 99mTc-MAG3 seems unsuitable for an accurate determination of the RPF.(ABSTRACT TRUNCATED AT 250 WORDS)..
  62. ncbi Radionuclide quantitation of renal function
    J J Sanger
    Division of Nuclear Medicine, New York University Medical Center Bellevue Hospital Center, New York 10016
    Urol Radiol 14:69-78. 1992
    ..Quantitative radionuclide studies of the kidneys provide comprehensive, reproducible, and objective assessments of renal function...
  63. ncbi Two-compartment, two-sample technique for accurate estimation of effective renal plasma flow: theoretical development and comparison with other methods
    J L Lear
    Department of Radiology, University of Colorado Health Sciences Center, Denver 80262
    Radiology 172:431-6. 1989
    ..The new two-compartment, two-sample technique yielded estimates of ERPF that more closely agreed with the reference multiple-sample method than either the single-sample or slope-intercept techniques...
  64. ncbi Diuresis renography. A simultaneous comparison between 131I-hippuran and 99Tcm-MAG3
    K Hvid-Jacobsen
    Department of Nuclear Medicine, University of Copenhagen, Herlev, Denmark
    Acta Radiol 31:83-6. 1990
    ..It is concluded, that MAG3 is superior to hippuran in the evaluation of patients with possible unilateral upper urinary tract obstruction by diuresis renography...
  65. ncbi Evaluation of intermittent drainage of the renal pelvis as seen in the isotope renogram
    G Granerus
    Department of Clinical Physiology, Gothenburg University, Sahlgrenska Hospital, Sweden
    Clin Physiol 9:161-9. 1989
    ..It is concluded that ID seen at renography during diuresis should not be regarded as evidence of obstruction of pelvic outflow but merely as an indication of a dilated upper urinary tract...
  66. ncbi Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction
    Kevin Damman
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Heart Fail 9:872-8. 2007
    ..Renal failure in heart failure is related to decreased cardiac output. However, little is known about its association with venous congestion...
  67. ncbi Urodynamics in enuretic children
    M J van der Vis-Melsen
    Department of Nuclear Medicine, Spaarne Ziekenhuis, Haarlem, The Netherlands
    Clin Nucl Med 17:200-5. 1992
    ..Upper urinary tract anomalies were identified in 5% of the children, anomalies of the upper and the lower urinary tract in 9.6%, and functional voiding disturbances in 16%...
  68. ncbi Single-dose subcutaneous iodine-131-iodohippurate for determination of renal plasma flow
    M E Grant
    Department of Medicine, University of Kansas Medical Center, Kansas City
    J Nucl Med 32:1452-4. 1991
    ..73 m2 (range 144.4 to 746.5 ml/min/1.73 m2) and highly correlated with RPFPAH (r = 0.883, p less than 0.0001). This technique permits prolonged studies of renal plasma flow under steady-state conditions without constant infusion...
  69. ncbi The mechanism and diagnostic value of angiotensin I converting enzyme inhibition renography
    D de Zeeuw
    Department of Nephrology, State University Hospital, Groningen, The Netherlands
    Am J Hypertens 4:741S-744S. 1991
    ..In conclusion, in an ideal setting as obtained in animal experiments, ACE inhibition improves the sensitivity of renographic studies to 100%. However, its value in the clinical setting needs more standardization...
  70. ncbi [Renal function during cardiac surgery with extracorporeal circulation]
    Guillermo Lema
    Departamentos de Anestesiología, Nefrologia, y Enfermedades Cardiovasculares, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 136:459-66. 2008
    ..Patients with valvular heart disease are at high risk of acute renal failure after surgery with extracorporeal circulation...
  71. ncbi Comparison of 99mTc-mercaptoacetyltriglycine and [131I]-o-iodohippurate elimination in perfused rat kidney
    Frantisek Trejtnar
    Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic
    Nucl Med Biol 30:45-9. 2003
    ..47. Both compounds were bound to proteins in the perfusate to a considerable extent. An analysis of renal handling showed that contribution of tubular secretion to the total excretion was 95% for OIH, and 97% for (99m)Tc-MAG3...
  72. pmc Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:361-8. 2011
    ..However, it is unknown whether endogenous vasopressin concentration is associated with disease severity in patients with ADPKD...
  73. ncbi Radionuclide evaluation of renal transplants
    E V Dubovsky
    Division of Nuclear Medicine, University of Alabama, Birmingham Medical Center
    Semin Nucl Med 18:181-98. 1988
    ....
  74. ncbi Renal plasma flow in rhesus monkeys infected with Plasmodium knowlesi
    S Areekul
    Department of Tropical Radioisotopes, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Southeast Asian J Trop Med Public Health 18:186-92. 1987
    ..These findings indicated that the renal plasma flow in the infected monkeys was depressed in proportion to the number of P. knowlesi parasites. The mechanism of reduced renal plasma flow was probably due to renal vasoconstriction...
  75. ncbi [Diagnostic value of radioisotope clearance in patients with a single kidney]
    W Hofmann
    Klinik für Urologie, Bereiches Medizin der Martin Luther Universität Halle Wittenberg
    Z Urol Nephrol 83:61-5. 1990
    ..In the present study of dynamic radioisotope investigations in patients with solitar kidney could be verified...
  76. ncbi Comparison of two methods of determining renal perfusion with and without captopril pretreatment in groups of patients with left ventricular dysfunction
    J G Motwani
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, U K
    Eur Heart J 15:226-31. 1994
    ..05). This reversed association and the weaker relationships between methods in post-infarction as compared to chronic heart failure patients may be related to interference by thrombolytic or aspirin treatments...
  77. ncbi [Phase 3 clinical study of 99mTc-MAG3 injectable, a dynamic renal imaging agent--comparison with 123I-OIH and 99mTc-DTPA]
    K Torizuka
    Fukui Medical School
    Kaku Igaku 31:183-98. 1994
    ..These results suggest that 99mTc-MAG3 injectable is safe and a useful radiopharmaceutical for diagnosis of renal and urinary disorders...
  78. ncbi Interventions in renal scintirenography
    E J Fine
    Jacobi Medical Center, Department of Nuclear Medicine, Bronx, NY 10461, USA
    Semin Nucl Med 29:128-45. 1999
    ..Finally, further investigations of exercise renography in essential hypertension have deepened the plausibility of a renal role in the etiology of perhaps 50% of affected individuals...
  79. ncbi Reproducibility of single-sample clearance of 99mTc-mercaptoacetyltriglycine and 131I-orthoiodohippurate
    C D Russell
    Division of Nuclear Medicine, University of Alabama Medical Center, Birmingham, USA
    J Nucl Med 40:1122-4. 1999
    ..For many years, we have routinely followed the renal function of patients with spinal cord injuries using a combination of radionuclide imaging and clearance measurement...
  80. ncbi Clearance and renal extraction of technetium-99m-L,L-ethylenedicysteine, I-131-ortho-iodohippurate and I-125-iothalamate in pigs
    S S Nielsen
    Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Skejby Section, Denmark
    Clin Physiol 19:338-43. 1999
    ..We conclude that 99mTc-EC is not a suitable tracer for measuring renal function by the single-injection plasma clearance technique in pigs. This is due to a decreasing renal extraction and a significant hepatic clearance...
  81. ncbi Reproducibility of 99Tcm-MAG3 clearance in normal volunteers with the two-sample method: comparison with 131I-OIH
    T Kanazawa
    Department of Radiology, Toyama Medical and Pharmaceutical University, Japan
    Nucl Med Commun 19:899-903. 1998
    ..There were no significant differences between the first and the second measurements of 99Tcm-MAG3 and 131I-OIH clearance, respectively. 99Tcm-MAG3 clearance was shown to be very similar to that of 131I-OIH in healthy volunteers...
  82. ncbi Kinetic parameter estimation from renal measurements with a three-headed SPECT system: a simulation study
    Eleonora Vanzi
    Department of Clinical Pathophysiology, University of Florence, Firenze, Italy
    IEEE Trans Med Imaging 23:363-73. 2004
    ..Within the limit of statistical fluctuations, DLSE results are unbiased whereas those of the conventional method are overestimated by 24%...
  83. ncbi Evaluation of (123)I-orthoiodohippurate single kidney clearance rate by renal sequential scintigraphy in a large cohort of likely normal subjects aged between 0 and 18 years
    Alessio Imperiale
    Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Eur J Nucl Med Mol Imaging 33:1483-90. 2006
    ..Age-related values of (123)I-orthoiodohippurate (OIH) single kidney clearance rate (Cl) were estimated in a large cohort of likely normal children aged between 0 and 18 years...
  84. ncbi Plain radiography, renography, and 99mTc-DMSA renal scintigraphy before and after extracorporeal shock wave lithotripsy for urolithiasis
    O Munck
    Department of Clinical Physiology Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark
    Acta Radiol 33:569-72. 1992
    ..In no patient did the scintigrams reveal scars. It is concluded that abdominal plain radiography of the urinary tract and probe renography are complementary and sufficient in the monitoring of patients with urolithiasis post ESWL...
  85. ncbi Differential associations between renal function and "modifiable" risk factors in patients with chronic heart failure
    Tom D J Smilde
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Res Cardiol 98:121-9. 2009
    ..Our aim was to determine different pathophysiologic markers that are associated with reduced renal function in CHF...
  86. ncbi [Design of radiolabeled antibody fragments for tumor-selective radioactivity localization--brush border enzyme-sensitive bond to decrease renal accumulation of radioactivity]
    Takahiro Mukai
    Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, 54 Shogoin, Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Yakugaku Zasshi 123:647-52. 2003
    ..for antibody fragments; the glycyl-lysine sequence in HML is a substrate for a brush border enzyme and m-iodohippuric acid is released by cleavage of the linkage...
  87. pmc (99m)Tc(CO)3(NTA): a (99m)Tc renal tracer with pharmacokinetic properties comparable to those of (131)I-OIH in healthy volunteers
    Andrew T Taylor
    Department of Radiology, Emory University, Atlanta, Georgia 30322, USA
    J Nucl Med 51:391-6. 2010
    ..Our objective was to compare the pharmacokinetics of these 2 tracers in healthy volunteers...
  88. ncbi Validation of the preparation of individual doses of (131)I-sodium o-iodohippurate ((131)I-hippuran)
    C Diaz
    Unitat de Radiofarmacia, Servei de Medicina Nuclear, Ciutat Sanitaria i Universitaria de Bellvitge, L Hospitalet de Llobregat, Barcelona, Spain
    Nucl Med Commun 22:975-9. 2001
    ....
  89. ncbi Enhanced sodium retention after acute nitric oxide blockade in mildly sodium loaded patients with essential hypertension
    Jesper N Bech
    Department of Medical Research, Holstebro Hospital, Aalborg Hospital and Aarhus University, Aarhus, Denmark
    Am J Hypertens 20:287-95. 2007
    ..The results suggest that patients with essential hypertension are highly dependent on NO to maintain sodium excretion...
  90. ncbi Simplified methods for estimation of 99mTc-pentetate and 131I-orthoiodohippurate plasma clearance in dogs and cats
    P Y Barthez
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, USA
    J Vet Intern Med 15:200-8. 2001
    ....
  91. ncbi Radionuclide renography: a personal approach
    A Taylor
    Emory University School of Medicine, Atlanta, GA, USA
    Semin Nucl Med 29:102-27. 1999
    ..To avoid unrealistic expectations on the part of the referring physician, it is often helpful to explain the likely differences in test results in these two-patient populations prior to the study...
  92. ncbi The effect of captopril on glucoheptonate uptake in experimental renal artery stenosis
    B Gale
    Department of Nuclear Medicine, Albert Einstein College of Medicine Montefiore Medical Center, Bronx, New York 10461
    Nucl Med Commun 13:110-3. 1992
    ..Moreover, the data support a potential value of glucoheptonate in captopril renography...
  93. ncbi [The value of combined computer-aided perfusion scintigraphy and renography in renal transplant patients with oliguria/anuria]
    A Miserez
    Universitätsinstitut für Medizinische Radiologie, Abteilung für Nuklearmedizin, Kantonsspital Basel, Schweiz
    Nuklearmedizin 28:100-12. 1989
    ..001). As a non-invasive examination which can also be carried out in emergency cases, combined computer-aided perfusion scintigraphy and renography should become part of standard diagnostic procedures for oligo/anuric graft recipients...
  94. ncbi Estimation of ERPF in adults from plasma clearance of 131I-hippuran using a single injection and one or two blood samples
    C D Russell
    Division of Nuclear Medicine, University of Alabama Hospital, Birmingham 35233
    Int J Rad Appl Instrum B 16:381-3. 1989
    ..Since the one-sample method is satisfactory for most clinical purposes, the two-sample method is recommended only when special accuracy is needed...
  95. ncbi Combination of DMSA-scintigraphy and hippuran renography in unilateral obstructive nephropathy. Improved prediction of recovery after intervention
    H S Thomsen
    Department of Nuclear Medicine, Københavns amts sygehus i Herlev, University of Copenhagen, Denmark
    Acta Radiol 28:653-5. 1987
    ..Use of the two radiopharmaceuticals, thus, may have great impact on the clinical decision, since in case of a difference some function may be saved by immediate intervention...
  96. ncbi Pyeloureteral dynamics. Pelvic pressure and kidney function in partial long-term ureteric obstruction
    J Mortensen
    Institute of Experimental Clinical Research, University of Aarhus, Denmark
    Scand J Urol Nephrol 23:25-9. 1989
    ..This clearly indicates, that the pelvic pressure at normal urine flow rate is an important factor in the pathogenesis of obstructive nephropathy...
  97. ncbi Alternating use of 123I and 131I hippuran for routine postoperative monitoring of transplanted kidneys is impracticable
    H S Thomsen
    Department of Nuclear Medicine, University of Copenhagen, Denmark
    Acta Radiol 28:365-7. 1987
    ..It is concluded that alternating routine use of the expensive 123I hippuran in control of renal grafts cannot be recommended...
  98. ncbi Technetium-99m MAG3, a comparison with iodine-123 and iodine-131 orthoiodohippurate, in patients with renal disorders
    R A Jafri
    Department of Nuclear Medicine, St Bartholomew s Hospital, London, United Kingdom
    J Nucl Med 29:147-58. 1988
    ....
  99. ncbi Effects of altered physiologic states on clearance and biodistribution of technetium-99m MAG3, iodine-131 OIH, and iodine-125 iothalamate
    A Taylor
    Department of Radiology, Emory University School of Medicine, Atlanta, Georgia 30322
    J Nucl Med 29:669-75. 1988
    ..In summary HPLC purified MAG3 behaved similarly to OIH under adverse physiologic conditions and the data continue to support the use of MAG3 as a potential clinical substitute for OIH...
  100. ncbi Abnormal captopril renogram with a technetium-99m-labeled hippuran analog
    B L Thorstad
    Department of Radiology, University of Alabama Hospital, Birmingham 35233
    J Nucl Med 29:1730-7. 1988
    ..Anatomic progression of disease was documented by angiography...
  101. ncbi Glomerular filtration rate in adults estimated from 123iodine-hippuran and 99mtechnetium-diethylenetriaminepenta-acetic acid gamma camera renography
    O Carlsen
    Department of Clinical Physiology and Nuclear Medicine, Vejle Hospital, Denmark
    Clin Physiol 8:399-406. 1988
    ..73 m2, respectively. The corresponding SD in TDGR were about 7 and 11 ml/min/1.73 m2. These standard deviations are sufficiently small for many clinical purposes and the method requires no blood samples or urine collections...

Research Grants2

  1. Decision Support Systems for MAG3 Renography
    Andrew Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  2. DEVELOPMENT OF TC-99M RENAL TUBULAR AGENTS
    Andrew Taylor; Fiscal Year: 2008
    ..abstract_text> ..