prilocaine

Summary

Summary: A local anesthetic that is similar pharmacologically to LIDOCAINE. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

Top Publications

  1. ncbi Lidocaine 4% cream compared with lidocaine 2.5% and prilocaine 2.5% or dorsal penile block for circumcision
    Victoria Tutag Lehr
    Department of Pharmacy Practice, The Eugene Applebaum College of Pharmacy and Health Sciences, Pediatric Pharmacology Research Unit, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 22:231-7. 2005
  2. ncbi Plasma levels of lidocaine, o-toluidine, and prilocaine after application of 8.5 g Oraqix in patients with generalized periodontitis: effect on blood methemoglobin and tolerability
    Britt Marie Herdevall
    Specialist Dental Clinic, Sodertalje, Sweden
    Acta Odontol Scand 61:230-4. 2003
  3. ncbi Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): enhancement of flap survival by EMLA
    Naci Karacal
    Department of Plastic and Reconstructive Surgery, Karadeniz Technical University, Trabzon, Turkey
    J Surg Res 124:134-8. 2005
  4. ncbi [Use of 2 % hyperbaric prilocaine for spinal anesthesia : sensitivity analysis in outpatient surgery]
    D A Vagts
    Krankenhaus Hetzelstift, Stiftstr 10, 67434, Neustadt an der Weinstraße, Deutschland
    Anaesthesist 62:271-7. 2013
  5. ncbi Intrapocket anesthesia for scaling and root planing: results of a double-blind multicenter trial using lidocaine prilocaine dental gel
    M K Jeffcoat
    Department of Periodontology, University of Alabama at Birmingham, School of Dentistry, 35294 0007, USA
    J Periodontol 72:895-900. 2001
  6. ncbi Evaluation of pain management interventions for neonatal circumcision pain
    B A Joyce
    Indiana University School of Nursing, NU 436, 1111 Middle Dr, Indianapolis, IN 46202, USA
    J Pediatr Health Care 15:105-14. 2001
  7. ncbi The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing
    J Friskopp
    Department of Periodontology, Public Dental Services, Kista, Sweden
    J Clin Periodontol 28:453-8. 2001
  8. ncbi Enhanced sensory relearning after nerve repair by using repeated forearm anaesthesia: aspects on time dynamics of treatment
    G Lundborg
    Department of Clinical Sciences Hand Surgery, Malmo University Hospital, Malmo, Sweden
    Acta Neurochir Suppl 100:121-6. 2007
  9. ncbi Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis
    J Friskopp
    Department of Periodontology, Public Dental Service, Kista, Sweden
    J Clin Periodontol 28:425-9. 2001
  10. ncbi Bier's block using prilocaine: safe, cheap and well tolerated
    S A W Pickering
    Department of Trauma and Orthopaedic Surgery, University Hospital, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Surgeon 1:283-5. 2003

Research Grants

  1. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 2003
  2. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 1999
  3. FETAL UPTAKE AND DISTRIBUTION OF LOCAL ANESTHETICS
    ROLAND KENNEDY; Fiscal Year: 1980
  4. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
  5. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
  6. Physical Activity and Quality of Life in Multiple Sclerosis
    Robert Motl; Fiscal Year: 2007

Detail Information

Publications216 found, 100 shown here

  1. ncbi Lidocaine 4% cream compared with lidocaine 2.5% and prilocaine 2.5% or dorsal penile block for circumcision
    Victoria Tutag Lehr
    Department of Pharmacy Practice, The Eugene Applebaum College of Pharmacy and Health Sciences, Pediatric Pharmacology Research Unit, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 22:231-7. 2005
    This study evaluated the efficacy and safety of lidocaine 4% cream (LMX4), compared with lidocaine 2.5% and prilocaine 2.5% (EMLA) or dorsal penile block (DPNB) for analgesia during circumcision...
  2. ncbi Plasma levels of lidocaine, o-toluidine, and prilocaine after application of 8.5 g Oraqix in patients with generalized periodontitis: effect on blood methemoglobin and tolerability
    Britt Marie Herdevall
    Specialist Dental Clinic, Sodertalje, Sweden
    Acta Odontol Scand 61:230-4. 2003
    Oraqix, a novel non-injectable anesthetic gel containing lidocaine and prilocaine and a thermosetting agent has been developed to provide localized anesthesia in periodontal pockets during scaling/root planing (SRP)...
  3. ncbi Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): enhancement of flap survival by EMLA
    Naci Karacal
    Department of Plastic and Reconstructive Surgery, Karadeniz Technical University, Trabzon, Turkey
    J Surg Res 124:134-8. 2005
    ..The topical analgesia cream, EMLA is a mixture of the substances lidocaine and prilocaine. EMLA causes a biphasic vascular response comprising initial blanching and vasoconstriction (maximal after 1...
  4. ncbi [Use of 2 % hyperbaric prilocaine for spinal anesthesia : sensitivity analysis in outpatient surgery]
    D A Vagts
    Krankenhaus Hetzelstift, Stiftstr 10, 67434, Neustadt an der Weinstraße, Deutschland
    Anaesthesist 62:271-7. 2013
    Hyperbaric prilocaine 2 % has been available for spinal anesthesia in Germany for 2 years and is characterized by a short duration of action, a lack of postspinal urine retention and a reduction of transient neurological syndromes...
  5. ncbi Intrapocket anesthesia for scaling and root planing: results of a double-blind multicenter trial using lidocaine prilocaine dental gel
    M K Jeffcoat
    Department of Periodontology, University of Alabama at Birmingham, School of Dentistry, 35294 0007, USA
    J Periodontol 72:895-900. 2001
    The efficacy of a novel anesthetic gel (lidocaine 25 mg/g plus prilocaine 25 mg/g in thermosetting agents) for non-invasive periodontal pocket anesthesia was evaluated.
  6. ncbi Evaluation of pain management interventions for neonatal circumcision pain
    B A Joyce
    Indiana University School of Nursing, NU 436, 1111 Middle Dr, Indianapolis, IN 46202, USA
    J Pediatr Health Care 15:105-14. 2001
    ..Further study is warranted. Neonates deserve interventions that will provide them with a less painful start in life...
  7. ncbi The anesthetic onset and duration of a new lidocaine/prilocaine gel intra-pocket anesthetic (Oraqix) for periodontal scaling/root planing
    J Friskopp
    Department of Periodontology, Public Dental Services, Kista, Sweden
    J Clin Periodontol 28:453-8. 2001
    A new non-injection anesthetic, lidocaine/prilocaine gel (Oraqix, AstraZeneca) in a reversible thermosetting system, has been developed to provide local anesthesia for scaling/root planing (SRP)...
  8. ncbi Enhanced sensory relearning after nerve repair by using repeated forearm anaesthesia: aspects on time dynamics of treatment
    G Lundborg
    Department of Clinical Sciences Hand Surgery, Malmo University Hospital, Malmo, Sweden
    Acta Neurochir Suppl 100:121-6. 2007
    ..In healthy individuals selective anaesthesia of the forearm results in improved hand sensation. Here we hypothesised that this principle would be valid also after nerve injury and repair...
  9. ncbi Plasma levels of lidocaine and prilocaine after application of Oraqix, a new intrapocket anesthetic, in patients with advanced periodontitis
    J Friskopp
    Department of Periodontology, Public Dental Service, Kista, Sweden
    J Clin Periodontol 28:425-9. 2001
    BACKGROUND, AIMS: Oraqix, a new non-injection local anesthetic, lidocaine/prilocaine gel 5%, has been developed to provide pain relief in association with periodontal probing and scaling/root planing (SRP)...
  10. ncbi Bier's block using prilocaine: safe, cheap and well tolerated
    S A W Pickering
    Department of Trauma and Orthopaedic Surgery, University Hospital, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Surgeon 1:283-5. 2003
    To examine the safety of prilocaine Bier's block performed for Colles fracture manipulation, and assess patient satisfaction.
  11. ncbi Combined analgesia and local anesthesia to minimize pain during circumcision
    A Taddio
    Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    Arch Pediatr Adolesc Med 154:620-3. 2000
    Pain of circumcision is only partially relieved by single modalities, such as penile nerve block, lidocaine-prilocaine cream, and sucrose pacifiers.
  12. ncbi A video study of pain relief during newborn male circumcision
    D J Garry
    Department of Obstetrics, Gynecology and Reproductive Medicine, Stony Brook University, Stony Brook, NY, USA
    J Perinatol 26:106-10. 2006
    The purpose of this investigation was to compare the effectiveness of dorsal penile nerve block and topical lidocaine-prilocaine anesthesia techniques for pain relief during circumcision.
  13. ncbi Dosage finding for low-dose spinal anaesthesia using hyperbaric prilocaine in patients undergoing perianal outpatient surgery
    V Gebhardt
    Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, Mannheim, Germany
    Acta Anaesthesiol Scand 57:249-56. 2013
    Hyperbaric prilocaine 20 mg/ml may be preferable for perianal outpatient surgery...
  14. ncbi Combined perianal-intrarectal (PI) lidocaine-prilocaine (LP) cream and lidocaine-ketorolac gel provide better pain relief than combined PI LP cream and periprostatic nerve block during transrectal prostate biopsy
    Luigi Cormio
    Department of Urology and Renal Transplantation, University of Foggia, Foggia, Italy
    BJU Int 109:1776-80. 2012
    ..add? Study Type - Harm Reduction RCT Level of Evidence 1b The combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block effectively counteracts probe and sampling related pain during transrectal ..
  15. ncbi Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine
    Manal Abu Al-Melh
    Faculty of Dentistry, Health Sciences Centre, Kuwait University, Kuwait
    J Clin Dent 16:53-6. 2005
    The aim of the study was to compare the analgesic effect of a topical benzocaine gel with that of a topical gel mixture of lidocaine/prilocaine (L/P).
  16. ncbi A prospective, double-blinded, randomized, clinical trial comparing the efficacy of 40 mg and 60 mg hyperbaric 2% prilocaine versus 60 mg plain 2% prilocaine for intrathecal anesthesia in ambulatory surgery
    Claudio Camponovo
    Department of Anesthesiology, University of Pittsburgh Medical Center, 5230 Center Avenue, Suite M 104, Pittsburgh, PA 15232, USA
    Anesth Analg 111:568-72. 2010
    In this prospective, double-blind, randomized trial we compared 60 mg and 40 mg of 2% hyperbaric prilocaine with 60 mg of 2% plain prilocaine for spinal anesthesia in terms of sensory block onset in outpatients undergoing elective short-..
  17. ncbi The use of lignocaine-prilocaine local anaesthetic cream for pain-free venepuncture in laboratory animals
    P A Flecknell
    Comparative Biology Centre, Medical School, Newcastle upon Tyne, UK
    Lab Anim 24:142-6. 1990
    ..EMLA cream represents a useful refinement of current techniques for intravenous injection in some species, and is especially valuable when the procedure is to be undertaken by an inexperienced operator...
  18. ncbi Petechial and purpuric eruption induced by lidocaine/prilocaine cream: a rare side effect
    Rodrigo Roldán-Marín
    Hospital General Dr Manuel Gea Gonzalez, Mexico City, Mexico
    J Drugs Dermatol 8:287-8. 2009
    Lidocaine/prilocaine cream is a topical anesthetic commonly used in pediatric and dermatologic practice to obtain local anesthesia...
  19. ncbi Spinal anaesthesia for ambulatory arthroscopic surgery of the knee: a comparison of low-dose prilocaine and fentanyl with bupivacaine and fentanyl
    A S Black
    Department of Anaesthesia and Pain Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia
    Br J Anaesth 106:183-8. 2011
    Prospective data on the use of prilocaine for ambulatory spinal anaesthesia remain limited. We compared the behaviour and characteristics of subarachnoid block using prilocaine and fentanyl with that of bupivacaine and fentanyl.
  20. ncbi Spinal procaine is less neurotoxic than mepivacaine, prilocaine and bupivacaine in rats
    Tamie Takenami
    Department of Anesthesiology, Kitasato University School of Medicine, Japan
    Reg Anesth Pain Med 34:189-95. 2009
    ..Therefore, we compared the histologic and functional changes induced by intrathecal injection of prilocaine, mepivacaine, procaine, and bupivacaine in rats.
  21. ncbi Randomized, double-blind, placebo-controlled prospective study of the efficacy of topical anaesthesia with a eutetic mixture of lignocaine 2.5% and prilocaine 2.5% for topical 5-aminolaevulinic acid-photodynamic therapy for extensive scalp actinic keratos
    S M Langan
    City of Dublin Skin and Cancer Hospital, Dublin 2, Ireland
    Br J Dermatol 154:146-9. 2006
    ..A recent study has shown that use of tetracaine gel (Ametop) did not significantly reduce pain associated with PDT...
  22. ncbi Pain management for neonatal circumcision
    A Taddio
    Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Drugs 3:101-11. 2001
    ..Less effective modalities include topical anaesthesia with lidocaine-prilocaine cream [Eutectic Mixture of Local Anaesthetics (EMLA)], lidocaine cream and oral administration of sucrose...
  23. ncbi Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures
    H Altunkaya
    Department of Anesthesiology, Zonguldak Karaelmas University, School of Medicine, Kozlu Zonguldak, Turkey
    Br J Anaesth 90:320-2. 2003
    ..The aim of this study was to compare the local anaesthetic effects of tramadol hydrochloride with prilocaine.
  24. ncbi Topical lidocaine-prilocaine spray for the treatment of premature ejaculation: a proof of concept study
    R Henry
    Department of Anesthesiology, Queen s University, Kingston, Ontario, Canada
    Int J Impot Res 15:277-81. 2003
    ..developed a local anesthetic combination, in a metered-dose aerosol delivery system, that delivers lidocaine and prilocaine in base form without organic solvents...
  25. ncbi Topical anesthetics update: EMLA and beyond
    P M Friedman
    Derm Surgery Associates, Houston, Texas 77030, USA
    Dermatol Surg 27:1019-26. 2001
    ..EMLA is the most commonly used agent, however, several new topical anesthetic agents have been released recently that claim increased efficacy and a faster onset of action...
  26. ncbi Optimum usage of prilocaine-lidocaine cream in premature ejaculation
    M K Atikeler
    Department of Urology, Firat University Medical Faculty, Elazig, Turkey
    Andrologia 34:356-9. 2002
    ..In this study, we evaluated the efficacy and optimum usage of lidocaine-prilocaine cream 5% in preventing premature ejaculation...
  27. ncbi Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation
    Wallace W Dinsmore
    Royal Victoria Hospital, Belfast, UK
    BJU Int 99:369-75. 2007
    To evaluate, in a phase II study, the efficacy and safety of a topical eutectic mixture for premature ejaculation (TEMPE), a metered-dose aerosol spray containing a eutectic mixture of lidocaine and prilocaine, as a treatment for PE.
  28. ncbi Pain management for newborn circumcision
    Ivy S Razmus
    Children s Hospital at Saint Francis, Tulsa, OK, USA
    Pediatr Nurs 30:414-7, 427. 2004
    ..To describe current newborn circumcision pain interventions and to identify which forms of analgesia were most effective...
  29. ncbi Improved sensibility of the foot after temporary cutaneous anesthesia of the lower leg
    Birgitta Rosén
    Department of Hand Surgery, University Hospital, Malmo, Sweden
    Neuroreport 20:37-41. 2009
    ..This novel finding may have considerable therapeutic potential in the treatment of foot sensibility disturbances in various neuropathies, such as diabetic neuropathy...
  30. ncbi Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access
    J Sawyer
    Prism Ideas Ltd, Regent House Princes Court, Beam Heath Way, Nantwich, Chesire CW5 7PQ, UK
    Br J Anaesth 102:210-5. 2009
    ..eutectic mixture of lidocaine 70 mg and tetracaine 70 mg, with a eutectic mixture of lidocaine 25 mg ml(-1) and prilocaine 25 mg ml(-1) (EMLA Cream)...
  31. ncbi The influence of a eutectic mixture of lidocaine and prilocaine on minor surgical procedures: a randomized controlled double-blind trial
    Faisal M Shaikh
    Department of Surgery, Mid Western Regional Hospital, Limerick, Ireland
    Dermatol Surg 35:948-51. 2009
    A eutectic mixture of lidocaine and prilocaine (EMLA) has been shown to be effective in reducing pain from needle sticks, including those associated with blood sampling and intravenous insertion.
  32. ncbi Stability and local toxicity evaluation of a liposomal prilocaine formulation
    Cintia M Saia Cereda
    Department of Biochemistry, Institute of Biology, State University of Campinas, Campinas, Sao Paulo, Brazil
    J Liposome Res 18:329-39. 2008
    This study reports a physicochemical stability evaluation of a previously reported liposomal prilocaine (PLC(LUV)) formulation (Cereda et al. J. Pharm. Pharmaceut. Sci...
  33. ncbi Allergic contact dermatitis from EMLA cream in a hemodialyzed patient
    Lidia Comba Pérez-Pérez
    Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, Spain
    Dermatitis 17:85-7. 2006
    ..Patch testing elicited a positive reaction to several allergens, including EMLA cream "as is" and prilocaine. The lesions resolved after topical treatment with corticosteroids.
  34. ncbi Acute improvement of hand sensibility after selective ipsilateral cutaneous forearm anaesthesia
    Anders Bjorkman
    Department of Hand Surgery, University Hospital Malmo, SE 20502 Malmo, Sweden
    Eur J Neurosci 20:2733-6. 2004
    ..Our findings open new perspectives for sensory re-education and rehabilitation following injury to the peripheral and central nervous system...
  35. ncbi Combination of adenosine with prilocaine and lignocaine for brachial plexus block does not prolong postoperative analgesia
    A Apan
    Department of Anaesthesiology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey
    Anaesth Intensive Care 31:648-52. 2003
    ..A supraclavicular BP block was performed by injecting a mixture totalling 35 ml made up of prilocaine 1% 10 ml and lignocaine 2% 20 ml with adrenaline 1:200,000, and adenosine 10 mg in 5 ml saline (Group 1) or 5 ml ..
  36. ncbi Can prilocaine infiltration alone be the most minimally invasive approach in terms of anesthesia during extracorporeal shock wave lithotripsy?
    Erdal Yilmaz
    Department of Urology, University of Kirikkale Faculty of Medicine, Kirikkale, Turkey
    Urology 68:24-7. 2006
    To evaluate the analgesic effect and utility of prilocaine infiltration alone for minimal morbidity during extracorporeal shock wave lithotripsy.
  37. ncbi Prilocaine plasma levels and methemoglobinemia in patients undergoing tumescent liposuction involving less than 2,000 ml
    N Lindenblatt
    Department of General Surgery, University of Rostock, Schillingallee 35, 18057 Rostock, Germany
    Aesthetic Plast Surg 28:435-40. 2004
    As a reaction to reported adverse outcomes after lidocaine infiltration in tumescent liposuction, prilocaine has gained increasing popularity...
  38. ncbi Comparison of ropivacaine 2 mg ml(-1) and prilocaine 5 mg ml(-1) for i.v. regional anaesthesia in outpatient surgery
    T T Niemi
    Department of Anaesthesiology and Intensive Care Medicine, Helsinki University Hospital Helsinki, Finland
    Br J Anaesth 96:640-4. 2006
    ..5%) after i.v. regional anaesthesia (IVRA). Whether ropivacaine 2 mg ml(-1) also exerts this advantage over prilocaine 5 mg ml(-1), the local anaesthetic of choice in IVRA in most European countries was investigated in this study.
  39. ncbi Intravenous regional anesthesia using prilocaine and neostigmine
    A Turan
    Department of Anaesthesiology and Reanimation, Medical Faculty, Trakya University, 22030 Edirne, Turkey
    Anesth Analg 95:1419-22, table of contents. 2002
    ..We conducted this study to evaluate the effects of neostigmine when added to prilocaine for IV regional anesthesia (IVRA)...
  40. ncbi EMLA cream versus dorsal penile nerve block for postcircumcision analgesia in children
    W Y Choi
    Department of Anaesthesia and Intensive Care, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong
    Anesth Analg 96:396-9, table of contents. 2003
    ..We conclude that preoperative application of EMLA cream is an effective and simple method to produce postcircumcision analgesia with a very small incidence of adverse effects...
  41. ncbi Effectiveness of nitrous oxide and analgesic cream (lidocaine and prilocaine) for prevention of pain during intramuscular botulinum toxin injections in children
    S Brochard
    Service de Medecine Physique et de Readaptation, Centre Hospitalo Universitaire Morvan, 5, avenue Foch, 29200 Brest, France
    Ann Phys Rehabil Med 52:704-16. 2009
    To evaluate the effectiveness of an analgesic protocol with nitrous oxide and anaesthetic cream (lidocaine and prilocaine, EMLA) for children undergoing botulinum toxin injections.
  42. ncbi [Topical anesthesia before vascular access in children. Comparison of a warmth-producing lidocaine-tetracaine patch with a lidocaine-prilocaine patch]
    S Soltesz
    Klinik für Anästhesie und Operative Intensivmedizin, Klinikum Leverkusen gGmbH, Am Gesundheitspark 11, 51375 Leverkusen, Deutschland
    Anaesthesist 59:519-23. 2010
    ..Therefore, many clinicians use a local anesthesia patch (EMLA) containing a mixture of lidocaine and prilocaine in order to reduce the stress for pediatric patients...
  43. ncbi Local anesthesia with 20-mL prilocaine infiltration: the ultimate point for analgesia during shockwave lithotripsy?
    Erdal Yilmaz
    Faculty of Medicine, Department of Urology, University of Kirikkale, Kirikkale, Turkey
    J Endourol 22:883-7. 2008
    The effectiveness of 10 mL and 20 mL local prilocaine infiltration for analgesic purposes during shockwave lithotripsy (SWL) was compared, and the differences in pain intensity and need for additional analgesics were defined.
  44. ncbi A comparison of prilocaine and lidocaine for intravenous regional anaesthesia for forearm fracture reduction in children
    Andrew J Davidson
    Department of Anaesthesia, Royal Children s Hospital, Parkville, Victoria, Australia
    Paediatr Anaesth 12:146-50. 2002
    In this prospective blinded randomized study, we compared prilocaine and lidocaine for intravenous regional anaesthesia for forearm fracture reduction in children.
  45. ncbi Magnesium added to prilocaine prolongs the duration of axillary plexus block
    Aytac Gunduz
    Department of Anaesthesia, Bandýrma Hospital, Bandýrma, Turkey
    Reg Anesth Pain Med 31:233-6. 2006
    The aim of this study was to evaluate the effect of the addition of magnesium to prilocaine on the duration of sensory and motor-nerve block.
  46. pmc Analgesia for venous cannulation: a comparison of EMLA (5 minutes application), lignocaine, ethyl chloride, and nothing
    I R Selby
    Anaesthetic Department, Hope Hospital, Lancashire, UK
    J R Soc Med 88:264-7. 1995
    ..01). The use of lignocaine did not result in significantly more failed cannulations than the control group. It was concluded that local anaesthesia should be used before venous cannulation, even for 20G cannulae...
  47. ncbi Methaemoglobinaemia secondary to topical lignocaine/ prilocaine in a circumcised neonate
    R T Couper
    Department of Paediatrics, University of Adelaide, Women s and Children s Hospital, South Australia, Australia
    J Paediatr Child Health 36:406-7. 2000
    The use of topical lignocaine/prilocaine (EMLA, Astra Pharmaceuticals, North Ryde, NSW, Australia) for pain relief for neonatal circumcision is becoming more prevalent...
  48. ncbi Combination of perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block for pain control during transrectal ultrasound guided prostate biopsy: a randomized, controlled trial
    Gianluca Giannarini
    Department of Urology, University of Pisa, Pisa, Italy
    J Urol 181:585-91; discussion 591-3. 2009
    ..We tested the efficacy and safety of combined perianal-intrarectal lidocaine-prilocaine cream and periprostatic nerve block during transrectal ultrasound guided prostate biopsy.
  49. ncbi Perianal and intrarectal anaesthesia for transrectal biopsy of the prostate: a prospective randomized study comparing lidocaine-prilocaine cream and placebo
    Marco Raber
    Istituto Scientifico Ospedale San Raffaele, Urology, Milan, Italy
    BJU Int 96:1264-7. 2005
    To assess the effectiveness of perianal and intrarectal lidocaine-prilocaine cream for prostate biopsy.
  50. ncbi Methemoglobinemia due to application of prilocaine during circumcision and the effect of ascorbic acid
    Perran Boran
    Dr Lutfi Kirdar Kartal Research and Training Hospital, 2nd Clinic of Pediatrics, Istanbul, Turkey
    J Pediatr Urol 4:475-6. 2008
    Local anesthesia with prilocaine has become a routine part of ambulatory circumcision procedures. Methemoglobinemia is a rare but potentially lethal complication of local anesthetics...
  51. ncbi Comparison of the effect of lidocaine-epinephrine and prilocaine-felypressine to alter macrophage functions
    Y Azuma
    Department of Pharmacology, Osaka Dental University, 8 1 Kuzuhahanazono cho, Hirakata, Osaka 573 1121, Japan
    Int Immunopharmacol 1:911-23. 2001
    In vitro treatment of macrophages with lidocaine-epinephrine or prilocaine-felypressine resulted in inhibition of their adhesion, chemotaxis and phagocytosis...
  52. ncbi Improved sensory relearning after nerve repair induced by selective temporary anaesthesia - a new concept in hand rehabilitation
    B Rosen
    Department of Hand Surgery, Lund University, University Hospital Malmo, Sweden
    J Hand Surg Br 31:126-32. 2006
    ..These results suggest that cutaneous forearm anaesthesia of the injured limb, in combination with sensory re-education, can enhance sensory recovery after nerve repair...
  53. ncbi Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine
    Richard K Yoon
    Division of Pediatric Dentistry, Columbia University College of Dental Medicine, New York City, NY, USA
    Pediatr Dent 31:377-81. 2009
    ..The purpose of this prospective study was to compare the efficacy of Oraqix to benzocaine while placing a rubber dam clamp during sealant placement on children...
  54. ncbi Injection pain of bupivacaine with epinephrine vs. prilocaine plain
    Michael J Wahl
    Wahl Family Dentistry, Wilmington, Del 19803, USA
    J Am Dent Assoc 133:1652-6. 2002
    b>Prilocaine plain has been described in the literature as causing less pain on injection than bupivacaine with epinephrine, possibly because of the higher pH of the prilocaine anesthetic solution.
  55. ncbi Comparison of hemodynamic effects of lidocaine, prilocaine and mepivacaine solutions without vasoconstrictor in hypertensive patients
    Bahadir Ezmek
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey
    J Appl Oral Sci 18:354-9. 2010
    ..The aim of this study was to compare hemodynamic effects of three different local anesthetics without vasoconstrictors during tooth extraction in hypertensive patients...
  56. ncbi Depth of cutaneous analgesia after application of a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA cream)
    C F Wahlgren
    Department of Dermatology, Karolinska Hospital and Institute, Stockholm, Sweden
    J Am Acad Dermatol 42:584-8. 2000
    EMLA cream, a eutectic mixture of lidocaine and prilocaine, is a topical anesthetic, frequently used to avoid pain during venipuncture and superficial surgery. However, the depth of analgesia needs further exploration.
  57. ncbi Evaluation of eutectic lidocaine/prilocaine cream (EMLA) for steroid joint injection in children with juvenile rheumatoid arthritis: a double blind, randomized, placebo controlled trial
    Yosef Uziel
    Divisions of Rheumatology and Clinical Pharmacology and Toxicology, The Hospital for Sick Children and the University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 30:594-6. 2003
    To evaluate the efficacy of eutectic lidocaine/prilocaine cream (EMLA) in reducing the pain associated with steroid joint injection in children with juvenile arthritis.
  58. ncbi Lidocaine and prilocaine toxicity in a patient receiving treatment for mollusca contagiosa
    S Touma
    West Virginia University, Morgantown, USA
    J Am Acad Dermatol 44:399-400. 2001
    ..a 3-year-old child with mollusca contagiosa whose caregiver applied a eutectic mixture of 5% lidocaine and prilocaine (EMLA) in excessive amounts with the subsequent development of adverse reactions, including methemoglobinemia ..
  59. ncbi Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy
    Marco Bragagni
    Department of Pharmaceutical Sciences, University of Florence, Florence, Italy
    J Liposome Res 20:315-22. 2010
    ..been investigated to develop a new delivery system with improved therapeutic activity of the local anesthetic, prilocaine (PRL)...
  60. ncbi Management of pain from heel lance with lidocaine-prilocaine (EMLA) cream: is it safe and efficacious in preterm infants?
    B Stevens
    Faculties of Nursing and Medicine, University of Toronto, Department of Pediatrics, The Hospital for Sick Children, Ontario, Canada
    J Dev Behav Pediatr 20:216-21. 1999
    ..A two-phase, randomized, controlled trial was undertaken to determine the safety and efficacy of lidocaine-prilocaine 5% cream (EMLA, Astra Pharmaceuticals, L.P, Westborough, MA) for relieving pain from heel lance...
  61. ncbi Plain articaine or prilocaine for spinal anaesthesia in day-case knee arthroscopy: a double-blind randomized trial
    M P Hendriks
    Department of Anesthesiology, Canisius Wilhelmina Hospital, PO Box 9015, 6500 GS Nijmegen, The Netherlands
    Br J Anaesth 102:259-63. 2009
    Both prilocaine and articaine are short-acting local anaesthetics suited for spinal anaesthesia for day-case knee arthroscopy...
  62. ncbi Topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial
    Marco Raber
    Istituto Scientifico Ospedale San Raffaele, Universita Vita Salute, Cattedra di Urologia, Milan, Italy
    Eur Urol 53:967-73. 2008
    To compare pain control results between periprostatic nerve block alone and combined with topical prilocaine-lidocaine cream as local anesthesia of prostate biopsy.
  63. ncbi Is only perianal anesthesia with lidocaine-prilocaine cream sufficient to decrease the pain during transrectal ultrasound-guided prostate biopsy? A prospective randomized study
    Engin Kandirali
    Department of Urology, Abant Izzet Baysal University, Izzet Baysal Medical Faculty, Bolu, Turkey
    Urol Int 82:262-5. 2009
    To determine the optimal place to apply the local anesthetic agent and to investigate the efficacy of lidocaine-prilocaine cream on the perianal and intrarectal region during prostate biopsy.
  64. ncbi [Coma in a child after treatment with the 'magic salve' lidocaine-prilocaine cream]
    J A H Eekhof
    Ned Tijdschr Geneeskd 150:2729-30; author reply 2730. 2006
  65. pmc Principles of brain plasticity in improving sensorimotor function of the knee and leg in healthy subjects: a double-blind randomized exploratory trial
    Eva Ageberg
    Department of Orthopedics, Clinical Sciences Lund, Lund University, Sweden
    BMC Musculoskelet Disord 10:99. 2009
    ..We hypothesized that temporary anesthesia of the skin area above and below the knee would improve sensorimotor function of the ipsilateral knee and leg...
  66. ncbi Effects of local injection of prilocaine-felypressin on the myocardial oxygen balance in dogs
    Kenji Miyachi
    Department of Dental Anesthesiology, Tokyo Dental College, Japan
    Eur J Oral Sci 111:339-45. 2003
    The authors investigated the effects of felypressin (Fely), a non-adrenergic vasoconstrictor, used together with prilocaine on myocardial oxygen balance. Six open-chest dogs were studied under urethane and alpha-chloralose anesthesia...
  67. ncbi Lidocaine-prilocaine administration during transrectal ultrasound-guided prostatic biopsy: a randomized, single-blind, placebo-controlled trial
    Maurizio De Maria
    Division of Urology, Department of Surgery, University of Pisa, Pisa, Italy
    J Endourol 20:525-9. 2006
    ..Various modalities have been recommended to alleviate the pain, but reports on efficacy are contradictory. We assessed the possible benefit of intrarectal and perianal lidocaine-prilocaine (EMLA) cream.
  68. ncbi Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates
    F Abad
    Research Unit, Hospital La Candelaria, Tenerife, Spain
    Acta Paediatr 90:160-5. 2001
    ..allocated to one of four treatment groups: placebo (2 ml spring water); 2 ml sucrose 24% w/v; 1 g lidocaine-prilocaine 5% cream (EMLA); or EMLA plus sucrose...
  69. ncbi Rapid cortical reorganisation and improved sensitivity of the hand following cutaneous anaesthesia of the forearm
    Anders Bjorkman
    Department of Hand Surgery, Lund University, University Hospital Malmo, Malmo, Sweden
    Eur J Neurosci 29:837-44. 2009
    ....
  70. ncbi Plasma concentrations of lignocaine and prilocaine after a 24-h application of analgesic cream (EMLA) to leg ulcers
    B Stymne
    Department of Dermatology, Orebro Medical Centre Hospital, SE 702 10 Orebro, Sweden
    Br J Dermatol 145:530-4. 2001
    Although the lignocaine (lidocaine)-prilocaine cream EMLA has been extensively studied for the relief of acute treatment-related pain from sharp leg ulcer debridement, no data exist on systemic absorption from prolonged application in ..
  71. ncbi A comparison of a needle-free injection system for local anesthesia versus EMLA for intravenous catheter insertion in the pediatric patient
    Nathalia Jimenez
    Department of Anesthesiology and Pain Medicine, Children s Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, WA 98105, USA
    Anesth Analg 102:411-4. 2006
    ..004). We did not find differences in the number of attempts for IV cannulation. J-Tip application of 1% buffered lidocaine before IV cannulation is not painful and has better anesthetic effectiveness compared with EMLA...
  72. ncbi Direct comparison of EMLA versus lidocaine for pain control in Nd:YAG 1,064 nm laser hair removal
    Robert A Guardiano
    Department of Dermatology, National Naval Medical Center, Bethesda, Maryland 20889, USA
    Dermatol Surg 31:396-8. 2005
    ..Although side effects are uncommon, pain is described by most patients undergoing long-pulsed neodymium:yttrium-aluminum-garnet (Nd:YAG) 1,064 nm laser therapy...
  73. ncbi [Application of EMLA creme before upper lid blepharoplasty]
    K Henrici
    Klinik und Poliklinik für Augenheilkunde, Ernst Moritz Arndt Universitat, Greifswald
    Ophthalmologe 102:794-7. 2005
    ..The injection of local anesthesia before upper lid blepharoplasty is perceived as unpleasant and painful by some patients...
  74. ncbi The wand versus traditional injection for mandibular nerve block in children and adolescents: perceived pain and time of onset
    A M Palm
    Municipal Dental Service for Children and Adolescents, Frederikssund, Denmark
    Pediatr Dent 26:481-4. 2004
    ....
  75. ncbi [Optimized use of Emla cream in children--secondary publication. A randomized, prospective, controlled comparison of two application regimes]
    Lydia Nørrelykke Gad
    Amtssygehuset i Glostrup, Operations og Anaestesiologisk Afdeling Y
    Ugeskr Laeger 167:404-7. 2005
  76. ncbi Efficacy of intraoral topical anesthetics in children
    Ekaterini Paschos
    Department of Orthodontics, Dental School, LMU University Munich, Goethestr 70, 80336 Munchen, Germany
    J Dent 34:398-404. 2006
    ..Only a few studies have been performed in children. Some non-placebo controlled studies have been carried out to compare the efficacy in reducing children's injection pain between different topical anesthetics..
  77. ncbi EMLA for painful procedures in infants
    Karen L Weise
    University of California, San Francisco, USA
    J Pediatr Health Care 19:42-7; quiz 48-9. 2005
    ..List the procedures for which EMLA has been used to control pain in infants. Describe the efficacy of EMLA vs. other agents in treating pain. Discuss the potential adverse effects of EMLA in infants. See page 48 for instructions...
  78. ncbi Quantification and analysis of pain in nonsurgical scaling and/or root planing
    Ingvar Magnusson
    Department of Oral Biology, Periodontal Disease Research Center, University of Florida, Gainesville, FL 32610 0442, USA
    J Am Dent Assoc 135:1747-54. 2004
    ..The authors discuss some of the challenges encountered when they interpreted the results of the clinical studies and present the results from an alternative analysis of the anesthetic efficacy...
  79. ncbi Local anesthesia in transrectal ultrasound-guided prostate biopsy: EMLA cream as a new alternative technique
    Hulya Basar
    Department of Anesthesiology and Reanimation, University of Kirikkale, Kirikkale, Turkey
    Scand J Urol Nephrol 39:130-4. 2005
    ..The aims of the present study were to evaluate the efficacy of eutectic mixture of local anesthetics (EMLA) cream in transrectal-guided prostate biopsy and to compare its effect with that of other injectable anesthetic procedures...
  80. ncbi Adverse effects of EMLA (lidocaine/prilocaine) cream and efficacy for the placement of jugular catheters in hospitalized cats
    Karin A Wagner
    Department of Medical Sciences, University of Wisconsin Madison, School of Veterinary Medicine, 53706 1102, USA
    J Feline Med Surg 8:141-4. 2006
    EMLA is a lidocaine/prilocaine cream used for topical analgesia in human pediatric patients...
  81. ncbi Relieving the pain of sentinel lymph node biopsy tracer injection
    Susan Fetzer
    Southern New Hampshire Medical Center, Nashua, NH, USA
    Clin J Oncol Nurs 12:668-70. 2008
    ..The use of the eutectic mixture of lidocaine and prilocaine (EMLA) cream to reduce tracer injection pain has been reported anecdotally...
  82. ncbi Topical anesthetic creams
    Susan Kaweski
    Aesthetic Arts Institute, San Diego, Calif 92123, USA
    Plast Reconstr Surg 121:2161-5. 2008
    ..This article provides an overview of topical anesthetic creams, including availability, composition, safety, and efficacy...
  83. ncbi Galactography without discomfort using lidocaine/prilocaine anesthetic cream
    J D Berná-Serna
    Department of Radiology, Virgen de la Arrixaca University Hospital, El Palmar, Spain
    Acta Radiol 49:22-4. 2008
    ..Galactography (ductography) is the technique of choice for studying pathologic nipple discharge. It is sometimes difficult or even impossible to perform cannulation of the ductal orifice because of the discomfort caused to the patient...
  84. ncbi Effect of eutectic mixture of local anesthetics (EMLA) for pain relief during suprapubic aspiration in young infants: a randomized, controlled trial
    Yoav Nahum
    Department of Pediatrics, Hadassah University Hospital, Mount Scopus Campus, Jerusalem, Israel
    Clin J Pain 23:756-9. 2007
    ..The purpose of this study was to determine whether a eutectic mixture of local anesthetics (EMLA) cream reduce the pain experienced by newborns and young infants undergoing suprapubic aspiration (SPA)...
  85. ncbi Editorial comment on: topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial
    Cesare Selli
    Department of Urology, University of Pisa, Ospedale Santa Chiara, Pisa, Italy
    Eur Urol 53:973-4. 2008
  86. ncbi Eutectic mixture of local anesthetic (EMLA) decreases pain during humeral block placement in nonsedated patients
    David Samson
    Department of Anesthesiology and Intensive Care, University Hospital of Toulouse, University Paul Sabatier, Toulouse, France
    Anesth Analg 105:512-5. 2007
    ..We evaluated the potential role of an euctectic mixture of local anesthetic (EMLA) cream application before performing midhumeral block...
  87. ncbi The analgesic efficacy of lidocaine/prilocaine (EMLA) cream during fine-needle aspiration biopsy of thyroid nodules
    Alptekin Gursoy
    Department of Endocrinology and Metabolism, Baskent University Faculty of Medicine, 5 Cadde No 48, 06490 Bahcelievler, Ankara, Turkey
    Clin Endocrinol (Oxf) 66:691-4. 2007
    ..Lidocaine/prilocaine cream, an eutectic mixture of local anaesthetics (EMLA), is a frequently used topical anaesthetic...
  88. ncbi Transdermal diclofenac patch vs eutectic mixture of local anesthetics for venous cannulation pain
    Anil Agarwal
    Department of Anaesthesia and Biostatistics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Can J Anaesth 54:196-200. 2007
    ..To compare the efficacy and side effects of transdermal diclofenac patch with eutectic mixture of local anesthetic (EMLA) cream in attenuating venous cannulation pain...
  89. ncbi Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection
    Manal Abu Al-Melh
    Department of Surgical Sciences, Faculty of Dentistry, Kuwait University, Safat, Kuwait
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e16-20. 2007
    The aim of this study was to compare the topical anesthetic effect of 20% benzocaine gel with 2.5% lidocaine/2.5% prilocaine (L/P) cream and gel on the pain experienced during palatal anesthetic infiltration.
  90. ncbi Effects of local anaesthesia on subdermal needle insertion pain and subsequent tests of microvascular function in human
    Jean Luc Cracowski
    Department of Human Physiology, University of Oregon, Eugene, OR 97403 1240, United States
    Eur J Pharmacol 559:150-4. 2007
    ..Therefore, we recommend its use in such conditions before performing microdialysis coupled with laser Doppler flowmetry in cohort studies aimed at studying microvascular dysfunction in patients with microvascular diseases...
  91. ncbi Evaluation of three topical anaesthetic agents against pain: a clinical study
    R Nayak
    Dept of Pedodontics and Preventive Dentistry, Manipal College of Dental Sciences, Mangalore
    Indian J Dent Res 17:155-60. 2006
    ....
  92. ncbi The need for pain control during scaling and root planing
    John C Gunsolley
    Baltimore College of Dental Surgery University of Maryland Dental School Department of Endodontics and Periodontics Baltimore, Maryland, USA
    Compend Contin Educ Dent 26:3-5. 2005
    ..The current most used form of pain control is local anesthesia injections. However, many patients object to the use of "the needle." Therefore, there is a need for a noninjectable form of pain control that is effective...
  93. ncbi Topical anesthesia with EMLA reduces pain during endomyocardial biopsy: a randomized trial
    Dianne H Leloudis
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    J Heart Lung Transplant 25:1164-6. 2006
    ..In 225 EMBxs, use of the eutectic mixture of lidocaine and prilocaine (EMLA) decreased pain score (-7.3 compared with placebo; p = 0...
  94. ncbi Efficacy of EMLA cream to reduce fear and pain associated with interferon beta-1a injection in patients with multiple sclerosis
    Marijean Buhse
    Stony Brook University School of Nursing, Stony Brook, NY, USA
    J Neurosci Nurs 38:222-6. 2006
    ..The 18 patients who completed the study experienced a statistically significant decrease in both scores. This study suggests that the use of EMLA cream may reduce the pain and fear associated with IM injections...
  95. ncbi Editorial comment on: topical prilocaine-lidocaine cream combined with peripheral nerve block improves pain control in prostatic biopsy: results from a prospective randomized trial
    Rolf von Knobloch
    Department of Urology, Franziskus Hospital Bielefeld, D 33615 Bielefeld, Germany
    Eur Urol 53:974-5. 2008
  96. ncbi Injection pain of prilocaine plain, mepivacaine plain, articaine with epinephrine, and lidocaine with epinephrine
    Michael J Wahl
    Department of Psychology, Temple University, Philadelphia, Pennsylvania, USA
    Gen Dent 54:168-71. 2006
    ..four different local anesthetics (articaine with epinephrine, lidocaine with epinephrine, mepivacaine plain, or prilocaine plain) via a maxillary buccal infiltration, palatal infiltration, or inferior alveolar block injection...
  97. ncbi Pain- and distress-reducing interventions for venepuncture in children
    J H Tak
    Child Care Health Dev 32:257-68. 2006
    ....
  98. ncbi Reducing venipuncture and intravenous insertion pain with eutectic mixture of local anesthetic: a meta-analysis
    Susan Jane Fetzer
    Department of Nursing, University of New Hampshire, USA
    Nurs Res 51:119-24. 2002
    ..The eutectic mixture of local anesthetics (EMLA), by producing dermal anesthesia through contact with intact skin, has become a major indication for the reduction of pain experienced during venipuncture (VE) and intravenous (IV) insertion...
  99. ncbi No effect of skin anesthesia on pain intensity ratings associated with elicitation of the H-reflex in the soleus muscle
    Robert W Motl
    Department of Exercise Science, University of Georgia, Athens, USA
    Int J Neurosci 114:1549-60. 2004
    ..The authors conclude that elicitation of the H-reflex in the soleus muscle results in low intensity pain, and the pain appears to be caused by activation of subcutaneous nociceptive afferent fibers of the tibial nerve...
  100. ncbi Perceptual integration of intramuscular electrical stimulation in the focal and the referred pain area in healthy humans
    Eva Kosek
    Department of Surgical Sciences, Karolinska Institute Hospital, S 171 77 Stockholm, Sweden
    Pain 105:125-31. 2003
    ..The fact that conditioning stimulation in m. infraspinatus generated referred pain in the dorsolateral upper arm, but not vice versa suggests that the divergence of the input is not reciprocally arranged...
  101. ncbi The efficacy of 5% lidocaine-prilocaine (EMLA) cream on pain during intravenous injection of propofol
    A McCluskey
    Department of Anesthesia, Stepping Hill Hospital, Stockport, United Kingdom
    Anesth Analg 97:713-4. 2003
    ..placebo-controlled study to assess the analgesic efficacy of pretreatment with topical 5% lidocaine-prilocaine (EMLA) cream in 90 ASA physical status I and II adult patients scheduled to undergo day-case gynecological ..

Research Grants6

  1. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 2003
    ..by a single preparation, called EMLA (AstraZeneca), which consists of a eutectic mixture of lidocaine and prilocaine bases...
  2. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 1999
    ..5%) and prilocaine base (2.5%). The major problem with EMLA is a very long onset time for dermal anesthesia, up to two hours...
  3. FETAL UPTAKE AND DISTRIBUTION OF LOCAL ANESTHETICS
    ROLAND KENNEDY; Fiscal Year: 1980
    ..Because local anesthetics possess varying physiochemical properties, we are studying lidocaine, mepivacaine, bupivacaine, etidocaine and prilocaine to relate the blood concentrations and uptake to these properties.
  4. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  5. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  6. Physical Activity and Quality of Life in Multiple Sclerosis
    Robert Motl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..