bupivacaine

Summary

Summary: A widely used local anesthetic agent.

Top Publications

  1. ncbi The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy
    N Hayashi
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 23:877-85. 1998
  2. ncbi Effect of dexmedetomidine added to spinal bupivacaine for urological procedures
    Mahmoud M Al-Mustafa
    Department of Anesthesia and Intensive Care, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan
    Saudi Med J 30:365-70. 2009
  3. ncbi Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways
    Jun Lu
    Dept of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong, China
    Eur J Pharmacol 657:51-8. 2011
  4. pmc Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats
    Parisa Partownavid
    Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Crit Care Med 40:2431-7. 2012
  5. ncbi Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial
    Alberto J Rodriguez-Navarro
    Department of Surgery, Hospital Padre Hurtado, Santiago, Chile
    Reg Anesth Pain Med 36:103-9. 2011
  6. ncbi Biochemical and microarray analyses of bupivacaine-induced apoptosis
    Akira Unami
    Faculty of Pharmaceutical Sciences, University of Tokushima, 1 Shomachi, Tokushima 770 8505, Japan
    J Toxicol Sci 28:77-94. 2003
  7. pmc Bupivacaine and triamcinolone may be toxic to human chondrocytes: a pilot study
    Hasan M Syed
    Department of Orthopaedic Surgery, Loma Linda University Medical Center, 11406 Loma Linda Drive, Suite 218, Loma Linda, CA 92354, USA
    Clin Orthop Relat Res 469:2941-7. 2011
  8. ncbi Bupivacaine--the deadly friend of intervertebral disc cells?
    Lilian Quero
    Spine Research Group, Competence Centre for Applied Biotechnology and Molecular Medicine, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Spine J 11:46-53. 2011
  9. ncbi Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine
    Stefania Leone
    Department of Anesthesia and Pain Therapy, University Hospital of Parma, Parma, Italy
    Acta Biomed 79:92-105. 2008
  10. ncbi Lithium attenuates bupivacaine-induced neurotoxicity in vitro through phosphatidylinositol-3-kinase/threonine-serine protein kinase B- and extracellular signal-regulated kinase-dependent mechanisms
    Z Wang
    Department of Geriatrics, First Affiliated Hospital with Nanjing Medical University, Nanjing, China
    Neuroscience 206:190-200. 2012

Research Grants

Detail Information

Publications342 found, 100 shown here

  1. ncbi The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy
    N Hayashi
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 23:877-85. 1998
    STUDY DESIGN: The effect of epidural injection of betamethasone or bupivacaine was investigated in an animal model of lumbar radiculopathy...
  2. ncbi Effect of dexmedetomidine added to spinal bupivacaine for urological procedures
    Mahmoud M Al-Mustafa
    Department of Anesthesia and Intensive Care, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan
    Saudi Med J 30:365-70. 2009
    To determine the effect of adding dexmedetomidine to bupivacaine for neuraxial anesthesia.
  3. ncbi Bupivacaine induces apoptosis via mitochondria and p38 MAPK dependent pathways
    Jun Lu
    Dept of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong, China
    Eur J Pharmacol 657:51-8. 2011
    ..Although the effect of bupivacaine on apoptosis is known, it remains unclear whether bupivacaine induces apoptosis via mitochondrial ..
  4. pmc Fatty-acid oxidation and calcium homeostasis are involved in the rescue of bupivacaine-induced cardiotoxicity by lipid emulsion in rats
    Parisa Partownavid
    Department of Anesthesiology, Division of Molecular Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Crit Care Med 40:2431-7. 2012
    Lipid emulsion has been shown to be effective in resuscitating bupivacaine-induced cardiac arrest but its mechanism of action is not clear...
  5. ncbi Comparison of neosaxitoxin versus bupivacaine via port infiltration for postoperative analgesia following laparoscopic cholecystectomy: a randomized, double-blind trial
    Alberto J Rodriguez-Navarro
    Department of Surgery, Hospital Padre Hurtado, Santiago, Chile
    Reg Anesth Pain Med 36:103-9. 2011
    ..laparoscopic cholecystectomy under a standardized general anesthesia with wound infiltration using either neoSTX or bupivacaine. We hypothesized that neoSTX would reduce pain compared with bupivacaine at 12 hrs postoperatively.
  6. ncbi Biochemical and microarray analyses of bupivacaine-induced apoptosis
    Akira Unami
    Faculty of Pharmaceutical Sciences, University of Tokushima, 1 Shomachi, Tokushima 770 8505, Japan
    J Toxicol Sci 28:77-94. 2003
    The mechanism by which apoptosis is induced by local anesthetic bupivacaine, a potent uncoupler of mitochondrial oxidative phosphorylation, was investigated...
  7. pmc Bupivacaine and triamcinolone may be toxic to human chondrocytes: a pilot study
    Hasan M Syed
    Department of Orthopaedic Surgery, Loma Linda University Medical Center, 11406 Loma Linda Drive, Suite 218, Loma Linda, CA 92354, USA
    Clin Orthop Relat Res 469:2941-7. 2011
    ..Given the frequency of use of these agents, it is important to know whether they are in fact toxic...
  8. ncbi Bupivacaine--the deadly friend of intervertebral disc cells?
    Lilian Quero
    Spine Research Group, Competence Centre for Applied Biotechnology and Molecular Medicine, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland
    Spine J 11:46-53. 2011
    b>Bupivacaine is commonly used as an adjunct during provocative discography and is administered intradiscally in patients with discogenic back pain...
  9. ncbi Pharmacology, toxicology, and clinical use of new long acting local anesthetics, ropivacaine and levobupivacaine
    Stefania Leone
    Department of Anesthesia and Pain Therapy, University Hospital of Parma, Parma, Italy
    Acta Biomed 79:92-105. 2008
    Levobupivacaine and ropivacaine, two new long-acting local anesthetics, have been developed as an alternative to bupivacaine, after the evidence of its severe toxicity...
  10. ncbi Lithium attenuates bupivacaine-induced neurotoxicity in vitro through phosphatidylinositol-3-kinase/threonine-serine protein kinase B- and extracellular signal-regulated kinase-dependent mechanisms
    Z Wang
    Department of Geriatrics, First Affiliated Hospital with Nanjing Medical University, Nanjing, China
    Neuroscience 206:190-200. 2012
    ..In this study, we evaluated the effects of lithium on bupivacaine (a frequently used LAs)-induced injury in mouse neuroblastoma neuro 2a (N2a) cells...
  11. ncbi Bupivacaine, levobupivacaine and ropivacaine: are they clinically different?
    Andrea Casati
    Department of Anaesthesiology, University of Parma, Italy
    Best Pract Res Clin Anaesthesiol 19:247-68. 2005
    Two new, long-acting local anaesthetics have been developed after the evidence of bupivacaine-related severe toxicity: levobupivacaine and ropivacaine...
  12. ncbi The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: a randomised, double-blind study
    S L Solanki
    Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Anaesth Intensive Care 41:51-6. 2013
    ..analgesia and adverse effects following intrathecal administration of dexmedetomidine or clonidine, both with bupivacaine, in trauma patients...
  13. pmc Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells
    Misako Harato
    Department of Anesthesiology, Aichi Medical University School of Medicine, Nagakute, Aichi 480 1195, Japan
    BMC Neurosci 13:149. 2012
    b>Bupivacaine-induced neurotoxicity has been shown to occur through apoptosis...
  14. ncbi Bupivacaine, ropivacaine, and morphine: comparison of toxicity on human hamstring-derived stem/progenitor cells
    Florian Haasters
    Experimental Surgery and Regenerative Medicine, Department of Surgery, Ludwig Maximilians University Munich, Nussbaumstr 20, 80336, Munich, Germany
    Knee Surg Sports Traumatol Arthrosc 19:2138-44. 2011
    b>Bupivacaine, ropivacaine, and morphine are commonly administered intraarticularly after anterior cruciate ligament (ACL) reconstruction. However, their effects on human tendon stem/progenitor cells (TSPC) have not been studied...
  15. ncbi Effect of bupivacaine on intervertebral disc cell viability
    Ho Lee
    Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    Spine J 10:159-66. 2010
    b>Bupivacaine is a local anesthetic commonly used to relieve or control pain in interventional spine procedures...
  16. ncbi Comparison of 0.5% levobupivacaine, 0.5% bupivacaine, and 2% lidocaine for retrobulbar anesthesia in vitreoretinal surgery
    Recep Aksu
    Department of Anesthesiology, Erciyes University School of Medicine, Kayseri Turkey
    Eur J Ophthalmol 19:280-4. 2009
    The authors compared the efficacy of local anesthetics levobupivacaine, bupivacaine, and lidocaine for retrobulbar anesthesia in vitreoretinal surgery.
  17. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..were made with a more distal injury (spared nerve injury model), using a different sodium channel blocker (bupivacaine depot) at the injury site...
  18. ncbi The efficacy and safety of 0.75% levobupivacaine vs 0.75% bupivacaine for peribulbar anaesthesia
    D J Birt
    Department of Anaesthesia, Derriforf Hospital, Plymouth, UK
    Eye (Lond) 17:200-6. 2003
    Levobupivacaine, the S(-)-enantiomer of racemic bupivacaine, is associated with a similar efficacy but a reduced potential for cardiovascular and central nervous system toxicity than racemic bupivacaine...
  19. ncbi Effects of adding magnesium to bupivacaine and fentanyl for spinal anesthesia in knee arthroscopy
    Hüban Dayioğlu
    Department of Anesthesiology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey
    J Anesth 23:19-25. 2009
    The aim of the study was to investigate the effects of adding intrathecal magnesium sulfate 50 mg to low-dose bupivacaine-fentanyl on the spread, duration, regression of spinal block, and postoperative analgesia in patients undergoing ..
  20. ncbi Analgesic efficacy of two doses of intrathecal midazolam with bupivacaine in patients undergoing cesarean delivery
    Smita Prakash
    Department of Anesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India
    Reg Anesth Pain Med 31:221-6. 2006
    In this prospective, randomized, double-blind, placebo-controlled study, we investigated the postoperative analgesic efficacy of 2 doses of intrathecal midazolam as an adjunct to bupivacaine for spinal anesthesia.
  21. pmc Neuropathic pain: early spontaneous afferent activity is the trigger
    Wenrui Xie
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Pain 116:243-56. 2005
    ..Similar results were obtained in both pain models, and with two blockade methods (200mg of a depot form bupivacaine at the injury site, or perfusion of the injured nerve just proximal to the injury site with TTX)...
  22. ncbi Minidose bupivacaine-fentanyl spinal anesthesia for surgical repair of hip fracture in the aged
    B Ben-David
    Department of Anesthesia, Western Galilee Hospital, Nahariya, Israel
    Anesthesiology 92:6-10. 2000
    ..The synergism between intrathecal opioids and local anesthetics may make it possible to achieve reliable spinal anesthesia with minimal hypotension using a minidose of local anesthetic...
  23. ncbi Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent
    Ji Seok Baik
    Department of Anesthesiology and Pain Medicine, Gyeongsang National University Hospital, Jinju, Korea
    Can J Physiol Pharmacol 89:467-76. 2011
    ..The nitric oxide - cyclic guanosine monophosphate pathway is involved in the endothelium-dependent attenuation of levobupivacaine-induced contraction...
  24. ncbi In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1456-64, table of contents. 2008
    ..neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, bupivacaine and ropivacaine...
  25. ncbi Intrathecal midazolam increases the analgesic effects of spinal blockade with bupivacaine in patients undergoing haemorrhoidectomy
    M H Kim
    Department of Anaesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Br J Anaesth 86:77-9. 2001
    ..double-blind study we aimed to evaluate the postoperative analgesic effects of intrathecal midazolam with bupivacaine following haemorrhoidectomy...
  26. ncbi Sufentanil added to hyperbaric bupivacaine for subarachnoid block in Caesarean section
    A de F de Assunção Braga
    State University of Campinas, Department of Anaesthesia, School of Medical Sciences, Campinas, Sao Paolo, Brazil
    Eur J Anaesthesiol 20:631-5. 2003
    ..We studied the quality of the block and its maternal-fetal repercussions when different doses of sufentanil were combined with hyperbaric bupivacaine using the intrathecal route in pregnant women undergoing Caesarean section.
  27. ncbi Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart
    Guy L Weinberg
    Department of Anesthesiology, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USA
    Reg Anesth Pain Med 31:296-303. 2006
    Infusion of a lipid emulsion has been advocated for treatment of severe bupivacaine cardiac toxicity. The mechanism of lipid rescue is unknown...
  28. ncbi Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    R W Colburn
    Department of Pharmacology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 79:163-75. 1997
    ..Perineural application of bupivacaine prior to SPCN prevented spinal microglial responses but not pain behaviors...
  29. ncbi Levobupivacaine: a review of its pharmacology and use as a local anaesthetic
    R H Foster
    Adis International Limited, Mairangi Bay, Auckland, New Zealand
    Drugs 59:551-79. 2000
    Based on findings that the cardiotoxicity infrequently observed with racemic bupivacaine shows enantioselectivity, i.e...
  30. ncbi Bupivacaine attenuates contractility by decreasing sensitivity of myofilaments to Ca2+ in rat ventricular muscle
    Yasushi Mio
    Department of Anesthesiology, The Jikei University School of Medicine, Tokyo, Japan
    Anesthesiology 97:1168-77. 2002
    b>Bupivacaine exhibits a cardiodepressant effect, the molecular mechanism(s) of which have yet to be fully understood. Bupivacaine may directly act on contractile proteins and thereby decrease myofibrillar Ca2+ sensitivity.
  31. pmc Suprascapular nerve block (using bupivacaine and methylprednisolone acetate) in chronic shoulder pain
    E M Shanahan
    Rheumatology Research Unit, Repatriation General Hospital, Daw Park South Australia, Australia 5041
    Ann Rheum Dis 62:400-6. 2003
    ..There have been no large randomised placebo controlled trials examining the efficacy of suprascapular nerve block for shoulder pain in arthritis and/or degenerative disease using pain and disability end points...
  32. ncbi Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    Yeong Ray Wen
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 107:312-21. 2007
    ..Nerve injury-induced ectopic spontaneous activity is essential for the generation of neuropathic pain. The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia...
  33. ncbi Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest
    Peter C Marwick
    Department of Anesthesiology and Critical Care, University of Stellenbosch and Tygerberg Academic Hospital, Tygerberg, South Africa
    Anesth Analg 108:1344-6. 2009
    Accidental intravascular administration of bupivacaine during performance of a brachial block precipitated convulsions followed by asystole...
  34. ncbi Triamcinolone decreases bupivacaine toxicity to intervertebral disc cell in vitro
    Ju Hyung Moon
    Department of Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Spine Hospital, Yonsei University College of Medicine, 712 Eonjuro, Gangnam Gu, Seoul, South Korea
    Spine J 12:665-73. 2012
    ..Several recent studies suggest cytotoxicity of bupivacaine, whereas others report protective and cytotoxic effects of corticosteroids on chondrocytes and intervertebral ..
  35. ncbi Bupivacaine induces apoptosis via ROS in the Schwann cell line
    C J Park
    Department of Dental Anesthesiology and Dental Research Institute, Seoul National University College of Dentistry, 28 Yongon dong Chongno gu, Seoul 110 744, Korea
    J Dent Res 84:852-7. 2005
    ..Among local anesthetics tested on the Schwann cell line, RT4-D6P2T, bupivacaine significantly induced cell death, measured by the methyl tetrazolium (MTT) assay, in a dose- (LD50 = 476 microM)..
  36. ncbi Levobupivacaine versus racemic bupivacaine in spinal anaesthesia for urological surgery
    Y Y Lee
    Department of Anaesthesiology and Operating Theatre Services, Kwong Wah Hospital, Hong Kong, S A R
    Anaesth Intensive Care 31:637-41. 2003
    Racemic bupivacaine is the most common local anaesthetic used intrathecally. This prospective, randomized, double-blind study compared the clinical efficacy and motor block of 0.5% levobupivacaine with 0...
  37. ncbi Levobupivacaine versus racemic bupivacaine for spinal anesthesia
    Christian Glaser
    Division of Anesthesiology and Intensive Care Medicine, Vienna City Hospital Floridsdorf, Austria
    Anesth Analg 94:194-8, table of contents. 2002
    Levobupivacaine is the pure S(-)-enantiomer of racemic bupivacaine but is less toxic to the heart and central nervous system...
  38. ncbi Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism
    Xiaohui Wang
    Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, China
    Neurotoxicology 31:101-12. 2010
    b>Bupivacaine is an amide type local anesthetic which is widely used for epidural anesthesia and nerve blockade in patients. However, local administration of bupivacaine could cause neuron injury showing transient neurologic symptoms...
  39. ncbi Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine-serine protein kinase B-dependent mechanism
    R Ma
    Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, PR China
    Neuroscience 167:329-42. 2010
    b>Bupivacaine is one of the amide type local anesthetics and is widely used for epidural anesthesia and blockade of nerves. Bupivacaine administration locally could result in neuron injury showing transient neurologic symptoms...
  40. ncbi Bupivacaine uncouples the mitochondrial oxidative phosphorylation, inhibits respiratory chain complexes I and III and enhances ROS production: results of a study on cell cultures
    Olga Cela
    Department of Biomedical Sciences, University of Foggia, Foggia, Italy
    Mitochondrion 10:487-96. 2010
    This study aimed to validate, in situ, proposed mechanisms of bupivacaine cytotoxicity pointing to impairment of the mitochondrial oxidative metabolism...
  41. ncbi Effect of bupivacaine on sevoflurane-induced preconditioning in isolated rat hearts
    R Arthur Bouwman
    Department of Anesthesiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center VUmc, Amsterdam, The Netherlands
    Eur J Pharmacol 647:132-8. 2010
    ..As an adjunct to general anesthesia, local and regional application of bupivacaine is often used...
  42. ncbi Levobupivacaine versus racemic bupivacaine for spinal anaesthesia in orthopaedic major surgery
    F Fattorini
    Department of Anaesthesiological Sciences Critical Medicine and Pain Therapy, University of Rome La Sapienza, Rome, Italy
    Minerva Anestesiol 72:637-44. 2006
    ..The aim of our study was to compare clinical and anaesthetic features of levobupivacaine and racemic bupivacaine when intrathecally administered in 60 patients undergoing major orthopaedic surgical procedures.
  43. ncbi Efficacy of low-dose bupivacaine in spinal anaesthesia for Caesarean delivery: systematic review and meta-analysis
    C Arzola
    Department of Anesthesia and Pain Management, Mount Sinai Hospital and University of Toronto, 600 University Avenue, Room 1514, Toronto, ON, Canada M5G 1X5
    Br J Anaesth 107:308-18. 2011
    ..Different strategies have been attempted to prevent spinal-induced hypotension, including the use of low-dose bupivacaine. We conducted a systematic search for randomized controlled trials comparing the efficacy of spinal bupivacaine ..
  44. ncbi Characterization of a new class of DNA delivery complexes formed by the local anesthetic bupivacaine
    C J Pachuk
    Wyeth Lederle Vaccines, 1 Great Valley Parkway, Malvern, PA 19355, USA
    Biochim Biophys Acta 1468:20-30. 2000
    b>Bupivacaine, a local anesthetic and cationic amphiphile, forms stable liposomal-like structures upon direct mixing with plasmid DNA in aqueous solutions...
  45. ncbi Thoracic epidural bupivacaine attenuates inflammatory response, intestinal lipid peroxidation, oxidative injury, and mucosal apoptosis induced by mesenteric ischemia/reperfusion
    Nurdan Bedirli
    Gazi University, Medical Faculty, Department of Anesthesiology and Reanimation, Ankara, Turkey
    Anesth Analg 113:1226-32. 2011
    ..We conducted this study to evaluate the effects of thoracic epidural anesthesia (TEA) on inflammatory response, lipid peroxidation, and oxidative stress in a rat model of mesenteric ischemia/reperfusion (I/R)...
  46. pmc Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system
    Dong Wang
    Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop St, E1641 Biomedical Science Tower, Pittsburgh, PA 15261, USA
    Spine J 11:139-46. 2011
    b>Bupivacaine is a local anesthetic commonly used for back pain management in interventional procedures. Cytotoxic effects of bupivacaine have been reported in articular cartilage and, recently, in intervertebral disc cell culture...
  47. ncbi Lipid resuscitation of bupivacaine toxicity: long-chain triglyceride emulsion provides benefits over long- and medium-chain triglyceride emulsion
    Zhengqian Li
    Department of Anesthesiology, The First Affiliated Hospital, Wenzhou Medical College, Zhejiang, China
    Anesthesiology 115:1219-28. 2011
    ....
  48. ncbi The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart
    Le Liu
    Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, 2 FuXue Road, Wenzhou City, Zhejiang Province, 325000, China
    Anesth Analg 114:886-93. 2012
    ..unclear whether lipid combined with epinephrine is superior or inferior to either drug alone in treating bupivacaine cardiotoxicity...
  49. ncbi Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest
    York A Zausig
    University of Regensburg, Department of Anaesthesiology, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Anesth Analg 109:1323-6. 2009
    ..As the postulated mechanism of action, the so-called "lipid sink" effect may depend on the lipophilicity of LAs. In this study, we investigated whether lipid effects differ with regard to the administered LAs...
  50. ncbi The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine
    Inas A M Radwan
    Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Anesth Analg 94:319-24, table of contents. 2002
    ..The effects of lidocaine, bupivacaine, mepivacaine, and ropivacaine were examined microscopically and quantitatively assessed using the growth cone ..
  51. ncbi The efficacy and safety of DepoFoam bupivacaine in patients undergoing bilateral, cosmetic, submuscular augmentation mammaplasty: a randomized, double-blind, active-control study
    John D Smoot
    Departments of Anesthesiology and Neurological Surgery, The Ohio State University, Columbus, Ohio, USA
    Aesthet Surg J 32:69-76. 2012
    ..Breast augmentation can result in significant postsurgical pain...
  52. ncbi The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain and morphine requirements after Caesarean section: a randomized controlled trial
    I van Tuijl
    Department of Anesthesiology, University Medical Center Utrecht, The Netherlands
    Br J Anaesth 97:365-70. 2006
    ..We investigated the effect of the addition of clonidine (75 microg) to hyperbaric bupivacaine on postoperative morphine consumption after Caesarean section in a randomized controlled double-blind trial.
  53. ncbi Comparison of articaine and bupivacaine/lidocaine for sub-Tenon's anaesthesia in cataract extraction
    P Gouws
    West of England Eye Unit, Royal Devon and Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK
    Br J Anaesth 92:228-30. 2004
    ..We have previously shown articaine to be superior to a standard mixture of bupivacaine 0.5%/lidocaine 2% for peribulbar anaesthesia...
  54. ncbi Bupivacaine provides rapid, effective periprostatic anaesthesia for transrectal prostate biopsy
    J C Rabets
    Glickman Urological Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    BJU Int 93:1216-7. 2004
    To examine the effectiveness of the longer acting agent bupivacaine in providing periprostatic anaesthesia during transrectal ultrasonography (TRUS)-guided biopsy, as the periprostatic injection of lidocaine has been shown to ..
  55. ncbi Efficacy and uptake of ropivacaine and bupivacaine after single intra-articular injection in the knee joint
    P N Convery
    Musgrave Park Hospital, Belfast, UK
    Br J Anaesth 87:570-6. 2001
    The efficacy of ropivacaine 100 mg (5 mg ml(-1)), 150 mg (7.5 mg ml(-1)) and 200 mg (10 mg ml(-1)) and bupivacaine 100 mg (5 mg ml(-1)) given by intra-articular injection into the knee after the end of surgery was studied in 72 ASA I-II ..
  56. ncbi Botulinum toxin A versus bupivacaine trigger point injections for the treatment of myofascial pain syndrome: a randomised double blind crossover study
    Corrie L Graboski
    Glenrose Rehabilitation Hospital, 10230 111Ave, Edmonton AB, T5G 0B7, Canada
    Pain 118:170-5. 2005
    ..The purpose of this study was to compare the effectiveness of trigger point injections using BTX A versus bupivacaine, both in combination with a home-based rehabilitation program...
  57. ncbi Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine
    Valentina Grishko
    Department of Orthopaedic Surgery, University of South Alabama, 3421 Medical Park Drive, Mobile, AL 36693, USA
    J Bone Joint Surg Am 92:609-18. 2010
    ..The purposes of this investigation were to study the effects of lidocaine, bupivacaine, and ropivacaine on human chondrocyte viability and mitochondrial function in vitro and to characterize the ..
  58. ncbi Toxic systemic reactions of bupivacaine and etidocaine
    C J Bacsik
    University of Minnesota School of Dentistry, Minneapolis, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79:18-23. 1995
    Since the introduction of the long-acting agents, bupivacaine in 1983 and etidocaine in 1985, to the dental local anesthetic armamentarium, their use has increased rapidly...
  59. ncbi Bupivacaine induces reactive oxygen species production via activation of the AMP-activated protein kinase-dependent pathway
    Jun Lu
    Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
    Pharmacology 87:121-9. 2011
    It was our aim to investigate whether AMP-activated protein kinase (AMPK) mediates the considerable increase in reactive oxygen species (ROS) and cell apoptosis induced by bupivacaine in the human neuroblastoma cell line SH-SY5Y.
  60. ncbi The effects of thoracic epidural analgesia with bupivacaine 0.25% on ventilatory mechanics in patients with severe chronic obstructive pulmonary disease
    E M Gruber
    Department of Cardiothoracic and Vascular Anesthesia and Intensive Care Medicine, University of Vienna, Austria
    Anesth Analg 92:1015-9. 2001
    ..50). We conclude that TEA with bupivacaine 0.25% can be used safely in end-stage COPD patients...
  61. ncbi Levobupivacaine vs. racemic bupivacaine in peribulbar anaesthesia: a randomized double blind study in ophthalmic surgery
    E Pacella
    Ophthalmological Science Department, University of Rome Sapienza, Rome, Italy
    Eur Rev Med Pharmacol Sci 14:539-44. 2010
    ..50% (S - enantiomer of racemic mixture of bupivacaine), for peribulbar anaesthesia in a randomized double blind study vs. racemic bupivacaine 0...
  62. ncbi Dose-response effects of spinal neostigmine added to bupivacaine spinal anesthesia in volunteers
    S S Liu
    Department of Anesthesiology, Virginia Mason Medical Center and the University of Washington, Seattle 98111, USA
    Anesthesiology 90:710-7. 1999
    Intrathecal adjuncts often are used to enhance small-dose spinal bupivacaine for ambulatory anesthesia...
  63. ncbi A comparison of the clinical anesthetic efficacy of 4% articaine and 0.5% bupivacaine (both with 1:200,000 epinephrine) for lower third molar removal
    Leonardo V L Gregorio
    Bauru School of Dentistry, University of Sao Paulo, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:19-28. 2008
    This study compared the clinical efficacy of 4% articaine (A200) and 0.5% bupivacaine (B200), both with 1:200,000 epinephrine, for lower third molar removal.
  64. ncbi The effect of adding magnesium sulphate to epidural bupivacaine and fentanyl in elective caesarean section using combined spinal-epidural anaesthesia: a prospective double blind randomised study
    A A Yousef
    Department of Anesthesia, Faculty of Medicine, Tanta University, Tanta, Egypt
    Int J Obstet Anesth 19:401-4. 2010
    ..Our study examined the effects of adding magnesium sulphate to epidural bupivacaine and fentanyl in patients undergoing elective caesarean section using combined spinal-epidural anaesthesia.
  65. ncbi A phase 3, randomized, placebo-controlled trial of DepoFoam® bupivacaine (extended-release bupivacaine local analgesic) in bunionectomy
    Michael Golf
    Premier Clinical Research Centers, Austin, TX, USA
    Adv Ther 28:776-88. 2011
    DepoFoam® bupivacaine (Pacira Pharmaceuticals, Inc...
  66. pmc Long-acting local anesthetics in dentistry
    A L Sisk
    Department of Oral and Maxillofacial Surgery, Medical College of Georgia School of Dentistry, Augusta 30912
    Anesth Prog 39:53-60. 1992
    ..b>Bupivacaine, for example, can cause significant cardiac depressant and dysrhythmogenic responses...
  67. ncbi Bispectral index does not correlate with observer assessment of alertness and sedation scores during 0.5% bupivacaine epidural anesthesia with nitrous oxide sedation
    Kyung Soo Park
    Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea
    Anesth Analg 103:385-9, table of contents. 2006
    ..It may be better to monitor sedation clinically (e.g., with the OAA/S scale) to determine the dose requirement and the adequacy of depth of sedation and hypnosis...
  68. ncbi Comparison of intrathecal magnesium, fentanyl, or placebo combined with bupivacaine 0.5% for parturients undergoing elective cesarean delivery
    H Unlugenc
    Department of Anesthesiology, Faculty of Medicine, Cukurova University, Adana, Turkey
    Acta Anaesthesiol Scand 53:346-53. 2009
    ..In this prospective, randomized, double-blind, study, we investigated the sensory, motor, and analgesic block characteristics of i.t. magnesium 50 mg compared with fentanyl 25 microg and saline when added to 0.5% bupivacaine (10 mg).
  69. ncbi Efficacy and comparison of 0.5% levobupivacaine with 0.75% ropivacaine for peribulbar anaesthesia in cataract surgery
    A Di Donato
    Department of Anaesthesia, Intensive Care and Pain Management, Military Policlinic, Concordia Hospital for Special Surgery, Winnipeg, Manitoba, Canada
    Eur J Anaesthesiol 23:487-90. 2006
    ..The aim of this study was to evaluate the efficacy of levobupivacaine 0.5% and to compare block quality vs. ropivacaine 0.75% in peribulbar anaesthesia...
  70. ncbi The analgesic effects of intraperitoneal and incisional bupivacaine with epinephrine after total abdominal hysterectomy
    A Ng
    Department of Anaesthesia, Critical Care, and Pain Management, University Hospitals of Leicester, NHS Trust, Leicester Royal Infirmary, Leicester LE1 5WW, UK
    Anesth Analg 95:158-62, table of contents. 2002
    The objective of our study was to see if incisional and intraperitoneal bupivacaine with epinephrine produces analgesia after total abdominal hysterectomy...
  71. ncbi The relative contributions of the disc and zygapophyseal joint in chronic low back pain
    A C Schwarzer
    Faculty of Medicine, University of Newcastle, Australia
    Spine (Phila Pa 1976) 19:801-6. 1994
    ..responded to both a screening zygapophyseal joint block using lignocaine and a confirmatory block using bupivacaine. Only three patients had both a positive discogram and a symptomatic zygapophyseal joint. CONCLUSIONS...
  72. ncbi Effect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine
    K C Cummings
    Department of Regional Practice Anesthesiology, Cleveland Clinic, Lakewood Hospital Department of Anesthesiology, 14519 Detroit Avenue, Lakewood, OH 44107, USA
    Br J Anaesth 107:446-53. 2011
    ..We thus tested the hypothesis that adding dexamethasone significantly prolongs the duration of ropivacaine and bupivacaine analgesia and that the magnitude of the effect differs among the two local anaesthetics.
  73. ncbi The median effective dose of bupivacaine, levobupivacaine, and ropivacaine after intrathecal injection in lower limb surgery
    Ying Y Lee
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    Anesth Analg 109:1331-4. 2009
    Intrathecal anesthesia is commonly used for lower limb surgery. Bupivacaine, levobupivacaine, and ropivacaine have all been used as intrathecal drugs, but their relative potency in this context has not been fully determined...
  74. ncbi Lung function under high thoracic segmental epidural anesthesia with ropivacaine or bupivacaine in patients with severe obstructive pulmonary disease undergoing breast surgery
    Harald Groeben
    Abteilung für Anästhesiologie und Intensivmedizin, Universitat Essen, Essen, Germany
    Anesthesiology 96:536-41. 2002
    ..Furthermore, ropivacaine supposedly evokes less motor blockade than bupivacaine and might minimize side effects...
  75. ncbi Antinociceptive synergy between the cannabinoid receptor agonist WIN 55,212-2 and bupivacaine in the rat formalin test
    Sinyoung Kang
    Department of Anesthesiology and Pain Medicine, Ewha Womans University Medical College, Seoul, Korea
    Anesth Analg 104:719-25. 2007
    ..We sought to determine the nature of the interaction between the intrathecal cannabinoid receptor agonist (WIN 55,212-2) and bupivacaine using the formalin test.
  76. ncbi Effects of intravenous dexmedetomidine on low-dose bupivacaine spinal anaesthesia in elderly patients
    J Y Hong
    Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    Acta Anaesthesiol Scand 56:382-7. 2012
    Dexmedetomidine (DMT) has been shown to prolong spinal anaesthesia. We evaluated the effects of intravenous DMT on low-dose bupivacaine spinal anaesthesia in elderly patients.
  77. ncbi Insulin effects on myocardial function and bioenergetics in L-bupivacaine toxicity in the isolated rat heart
    S N Stehr
    Medical Faculty Carl Gustav Carus, Department of Anaesthesiology and Intensive Care Medicine, Dresden, Germany
    Eur J Anaesthesiol 24:340-6. 2007
    A positive effect of insulin-glucose-potassium infusion in severe bupivacaine-induced cardiovascular collapse has been described in vivo...
  78. ncbi Intraperitoneal application of bupivacaine plus morphine for pain relief after laparoscopic cholecystectomy
    J Hernández-Palazón
    Department of Anaesthesia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
    Eur J Anaesthesiol 20:891-6. 2003
    ..This study was aimed at assessing the analgesic effect of the intraperitoneal administration of bupivacaine and morphine in patients undergoing laparoscopic cholecystectomy.
  79. pmc Supraphysiologic temperature enhances cytotoxic effects of bupivacaine on bovine articular chondrocytes in an in vitro study
    R Nelson Mead
    Department of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, Louisiana, USA
    Arthroscopy 28:397-404. 2012
    The purpose of this study was to determine the effects of temperature or 0.25% bupivacaine treatment in combination with supraphysiologic temperatures on chondrocyte viability.
  80. ncbi Comparative study of two local anesthetics in the surgical extraction of mandibular third molars: bupivacaine and articaine
    Anna Trullenque-Eriksson
    Department of Oral and Facial Medicine and Surgery, Faculty of Dentistry, Universidad Complutense de Madrid, Plaza Ramon y Cajal s n, Ciudad Universitaria, 28040 Madrid
    Med Oral Patol Oral Cir Bucal 16:e390-6. 2011
    ..It has been suggested that the longer duration of action of bupivacaine associated with the residual analgesia and the gradual onset of pain, could decrease the need for analgesics ..
  81. ncbi Spinal anaesthesia with articaine 5% vs bupivacaine 0.5% for day-case lower limb surgery: a double-blind randomized clinical trial
    T Dijkstra
    Department of Hospital Pharmacy, Reinier de Graaf Groep, PO Box 5011, 2600 GA Delft, The Netherlands
    Br J Anaesth 100:104-8. 2008
    ..Articaine is believed to act faster and to have a shorter duration of action than bupivacaine, but there are no conclusive data available...
  82. ncbi Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes
    Samantha L Piper
    J Bone Joint Surg Am 90:986-91. 2008
    It has been shown that bupivacaine, the most commonly used local anesthetic for postoperative intra-articular use, is cytotoxic to bovine articular chondrocytes in vitro...
  83. ncbi Comparison of articaine and bupivacaine/lidocaine for single medial canthus peribulbar anaesthesia
    K G Allman
    Department of Anaesthesia, Royal Devon and Exeter Hospital, Exeter, UK
    Br J Anaesth 87:584-7. 2001
    ..5% bupivacaine and 2% lidocaine for peribulbar anaesthesia in cataract surgery, using a single medial canthus injection ..
  84. ncbi Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity
    Guy Weinberg
    Department of Anesthesiology, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612, USA
    Reg Anesth Pain Med 28:198-202. 2003
    ..in rats that intravenous infusion of a lipid emulsion increases survival in resuscitation from severe bupivacaine cardiac toxicity...
  85. ncbi Effects of dexmedetomidine on the duration of anaesthesia and wakefulness in bupivacaine epidural block
    I Coskuner
    Anesthesiology and Reanimation Department, Yuzuncu Yil University, Medical Faculty, Van, Turkey
    Eur J Anaesthesiol 24:535-40. 2007
    The purpose of this study was to examine the effects of intravenous dexmedetomidine on the duration of bupivacaine-induced epidural anaesthesia and level of wakefulness and the respective side-effects.
  86. ncbi Dexamethasone with bupivacaine increases duration of analgesia in ultrasound-guided interscalene brachial plexus blockade
    Peter A Vieira
    Department of Anesthesiology, Baystate Medical Center, Springfield, Massachusetts 01199, USA
    Eur J Anaesthesiol 27:285-8. 2010
    ..However, it has not been evaluated when given in conjunction with bupivacaine and clonidine to provide blockade of the brachial plexus at the interscalene level...
  87. ncbi Femoral nerve block for total knee arthroplasty patients: a method to control postoperative pain
    Myron J Szczukowski
    Orthopedic Center, Easton, Maryland 21601, USA
    J Arthroplasty 19:720-5. 2004
    ..5% bupivacaine with epinephrine 1:200,000, on pain control following total knee arthroplasty (TKA)...
  88. ncbi Investigation of systemic bupivacaine toxicity using the in situ perfused working heart-brainstem preparation of the rat
    Anthony E Pickering
    Sir Humphry Davy Department of Anaesthesia, Royal Infirmary, University of Bristol, Bristol BS2 8HW, UK
    Anesthesiology 97:1550-6. 2002
    The inadvertent systemic administration of bupivacaine has been associated with fatal cardiovascular collapse. Systemic bupivacaine may affect neural control of the cardiovascular system in addition to having toxic actions on the heart...
  89. ncbi A comparison of intrathecal plain solutions containing ropivacaine 20 or 15 mg versus bupivacaine 10 mg
    Helena Kallio
    Department of Anesthesia, Forssa District Hospital, PO Box 42, FIN 30101 Forssa, Finland
    Anesth Analg 99:713-7, table of contents. 2004
    ..which blocks sensory nerve fibers more readily than motor fibers, is considered to be less potent than bupivacaine. Our hypothesis was that, when used in spinal anesthesia for day surgery, ropivacaine 15 and 20 mg would ..
  90. ncbi A novel liposomal bupivacaine formulation to produce ultralong-acting analgesia
    Gilbert J Grant
    Department of Anesthesiology, New York University School of Medicine, New York, New York 10016, USA
    Anesthesiology 101:133-7. 2004
    ..The authors prepared and characterized a novel liposomal bupivacaine formulation using remote loading of bupivacaine along an ammonium sulfate gradient and assessed its efficacy in ..
  91. ncbi Bupivacaine myotoxicity is mediated by mitochondria
    William Irwin
    Department of Biomedical Sciences, University of Padova and the Consiglio Nazionale delle Ricerche Units for the Study of Muscle Pathophysiology and Biomembranes, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 277:12221-7. 2002
    We have investigated the effects of the myotoxic local anesthetic bupivacaine on rat skeletal muscle mitochondria and isolated myofibers from flexor digitorum brevis, extensor digitorum longus, soleus, and from the proximal, striated ..
  92. pmc Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury
    Marc R Suter
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Pain 5:53. 2009
    ..of transient receptor potential vanilloid subtype 1 (TRPV1) positive fibers (mostly C- and Adelta-fibers) and bupivacaine microspheres to block all fibers of the sciatic nerve in rats before spared nerve injury (SNI), and observed ..
  93. ncbi Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block
    G E Kanazi
    Department of Anesthesiology, American University of Beirut Medical Center, Beirut, Lebanon
    Acta Anaesthesiol Scand 50:222-7. 2006
    The purpose of this study was to compare the onset and duration of sensory and motor block, as well as the hemodynamic changes and level of sedation, following intrathecal bupivacaine supplemented with either dexmedetomidine or clonidine.
  94. pmc Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat
    Chad M Brummett
    Department of Anesthesiology, Division of Pain Medicine, The University of Michigan Health System, 7433 Medical Sciences Building 1, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 5615, USA
    Anesthesiology 109:502-11. 2008
    ..The current study was designed to test the hypothesis that high-dose dexmedetomidine added to local anesthetic would increase the duration of sensory and motor blockade in a rat model of sciatic nerve blockade without causing nerve damage...
  95. ncbi The in vitro effects of bupivacaine on articular chondrocytes
    C R Chu
    Cartilage Restoration Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, School of Medicine, 3471 Fifth Ave, Suite 911, Pittsburgh, Pennsylvania 15213, USA
    J Bone Joint Surg Br 90:814-20. 2008
    We have studied the effects of bupivacaine on human and bovine articular chondrocytes in vitro. Time-lapse confocal microscopy of human articular chondrocytes showed > 95% cellular death after exposure to 0...
  96. ncbi The dose response and effects of dexamethasone on bupivacaine microcapsules for intercostal blockade (T9 to T11) in healthy volunteers
    Dan J Kopacz
    Department of Anesthesiology, Virginia Mason Clinic, Seattle, Washington, 98111 USA
    Anesth Analg 96:576-82, table of contents. 2003
    Biodegradable microcapsules containing bupivacaine/dexamethasone produce an anesthetic duration of 7-11 days in animal models...
  97. ncbi The effect of adding intrathecal magnesium sulphate to bupivacaine-fentanyl spinal anaesthesia
    M Ozalevli
    Department of Anaesthesiology, Faculty of Medicine, Cukurova University, Adana, Turkey
    Acta Anaesthesiol Scand 49:1514-9. 2005
    ..In this prospective, randomized, double-blind, controlled study, we investigated the effect of adding IT magnesium sulphate to bupivacaine-fentanyl spinal anaesthesia.
  98. ncbi Toxicity of local anaesthetics
    B Cox
    Department of Anesthesiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Best Pract Res Clin Anaesthesiol 17:111-36. 2003
    ..2 to 0.01%. Peripheral nerve blocks are associated with the highest incidence of systemic toxicity (7.5 per 10,000) and the lowest incidence of serious neural injury (1.9 per 10,000)...
  99. ncbi Side-effects of epidural infusions of opioid bupivacaine mixtures
    J A Gedney
    Department of Anaesthesia, Norfolk and Norwich Hospital, UK
    Anaesthesia 53:1148-55. 1998
    ..1 mg.ml-1), morphine (0.05 mg.ml-1) and pethidine (1.0 mg.ml-1) used by infusion in combination with bupivacaine has been compared. One hundred and sixty patients were studied, 32 receiving each opioid...
  100. ncbi Midkine and its receptor in regenerating rat skeletal muscle after bupivacaine injection
    Harutoshi Sakakima
    School of Health Sciences, Faculty of Medicine, Kyoto University, 53 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Acta Histochem 108:357-64. 2006
    ..examined for up to 14 days in a chemically injured rat muscle regeneration process caused by the injection of bupivacaine using immunohistochemical and Western blot analysis...
  101. ncbi In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage
    Constance R Chu
    Department of Orthopaedic Surgery, University of Pittsburgh, 200 Lothrop Street, BST E1640, Pittsburgh, PA 15261, USA
    J Bone Joint Surg Am 92:599-608. 2010
    ..in vitro studies have demonstrated chondrotoxic effects of local anesthetics, with the greatest emphasis on bupivacaine toxicity. This in vivo study was conducted to determine whether a single intra-articular injection of 0...

Research Grants59

  1. Cocaine disruption of maternal motivation: preference for pups vs. cocaine
    MARIANA PEREIRA ARBOLEYA; Fiscal Year: 2010
    ..the functional role of these sites in the expression of motivated choices by transiently inactivating (bupivacaine infusion) each of them and then testing stimulus-associated environment preference (Specific Aim I)...
  2. Nanoparticle scavengers for in vivo sequestration of overdosed drug molecules
    Zhiguo Zhou; Fiscal Year: 2013
    ..In particular, accidental overdose of bupivacaine, a local anesthetic has been reported to cause many cases of cardiac arrest and death...
  3. Maternal rat preferences for pups versus cocaine
    JOAN IRENE MORRELL; Fiscal Year: 2010
    ..a dual choice paradigm? I will test this using neuroanatomical site specific and transient inactivation (with bupivacaine a local anesthetic) of the mPOA during CPP test. B...
  4. Extraocular Muscle (EOM) Responses to Bupivacaine Injection
    Alan B Scott; Fiscal Year: 2012
    ..Hypertrophy of fast muscle, such as EOM, is a consistent consequence of intramuscular injection of bupivacaine (BUP) in animals...
  5. Actions of Local Anesthetics on NMDA Receptors
    Meaghan Paganelli; Fiscal Year: 2013
    ..This project will evaluate the mechanism by which bupivacaine and lidocaine, two amide local anesthetics widely used in clinical practice inhibit NMDA receptor currents...
  6. A Photo-triggered on-demand drug delivery system for chronic pain
    BRIAN PAUL TIMKO; Fiscal Year: 2012
    ..state permeability of the membrane to a number of compounds, including tetrodotoxin (TTX), saxitoxin (STX), bupivacaine, and dexamethasone...
  7. Peripheral Nerve Blocks with Multimodal Analgesics
    Brian Williams; Fiscal Year: 2009
    ..Sustained-release local anesthetics (e.g., microcapsulated bupivacaine) have not been successful in meeting these objectives...
  8. SKELETAL MUSCLE MICROVASCULAR PERFUSION IN HYPERTENSION
    Sarah Gray; Fiscal Year: 1999
    ....
  9. PROLONGED DURATION LOCAL ANESTHESIA
    DANIEL KOHANE; Fiscal Year: 2004
    ..respiratory distress, seizures, death) when injected alone, or in conjunction with microspheres containing bupivacaine and/or dexamethasone...
  10. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 1999
    ..lidocaine, bupivacaine) do not have the penetration properties needed for dermal anesthesia...
  11. CONTROL OF NEURAL FUNCTION IN ANESTHESIA
    Gary Strichartz; Fiscal Year: 2001
    ..Drugs to be tested include traditional local anesthetics (lidocaine and bupivacaine) in combination with capsaicin (a vanilloid receptor agonist), tetrodotoxin and saxitoxin (selective sodium ..
  12. FETAL UPTAKE AND DISTRIBUTION OF LOCAL ANESTHETICS
    ROLAND KENNEDY; Fiscal Year: 1980
    ..Because local anesthetics possess varying physiochemical properties, we are studying lidocaine, mepivacaine, bupivacaine, etidocaine and prilocaine to relate the blood concentrations and uptake to these properties.
  13. Androgen regulation of skeletal muscle regeneration
    James Carson; Fiscal Year: 2006
    ..This proposal's overall purpose is to determine if bupivacaine injection-induced mouse skeletal muscle regeneration is sensitive to circulating androgen levels, and if this ..
  14. IMPROVEMENTS IN PERINEURAL LOCAL ANESTHETIC BLOCK
    DAVID MASTERS; Fiscal Year: 2000
    ..This project focuses on 3-5 days of controlled bupivacaine release to a perisciatic nerve site to produce a pharmacotherapy that is safer and more efficacious than ..
  15. RESPIRATORY CONTROL DURING EXERCISE
    Philip Clifford; Fiscal Year: 1993
    ..1) application of a new surgical technique for total cardiopulmonary denervation, 2) epidural administration of bupivacaine to produce differential sensory and motor blockade, 3) intrathecal administration of morphine to block a ..
  16. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005
    ..We will also establish an isolated heart model to study the potential for clinical application of TZDs to treat acute cocaine cardiac toxicity. ..
  17. Role of IGF-1 In Diastolic Dysfunction of Aging
    Leanne Groban; Fiscal Year: 2003
    ..This study will provide the groundwork for future studies examining how IGF-1 signaling may modulate the programming and gene expression of the senescent myocardium. ..
  18. CHONDROPROTECTIVE EFFECTS OF SUPEROXIDE DISMUTASE
    Constance Chu; Fiscal Year: 2002
    ..These studies will also serve to improve understanding of the relative roles of NO and peroxynitrite on the pathophysiology of arthritis. ..
  19. Striatal Acetylcholine and Behavioral Flexibility
    MICHAEL RAGOZZINO; Fiscal Year: 2005
    ....
  20. MOLECULAR BASIS OF LIGAND/SODIUM CHANNEL INTERACTIONS
    GING WANG; Fiscal Year: 2002
    ....
  21. THERAPEUTIC NA+ CHANNEL BLOCKERS: RECEPTOR & DRUG DESIGN
    GING WANG; Fiscal Year: 2007
    ..Such drugs, either taken orally or injected locally, may be beneficial for patients with chronic and intractable cancer pain. ..
  22. Aging, Serotonin and Reversal Learning
    MICHAEL RAGOZZINO; Fiscal Year: 2008
    ..These studies have the potential of developing a novel treatment for the learning and memory deficits observed in aging and Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  23. AOSSM Post-Joint Injury Osteoarthritis Conference
    Constance Chu; Fiscal Year: 2008
    ..This symposium will bring doctors and scientists together to develop research plans to find new methods to prevent this from happening. [unreadable] [unreadable] [unreadable] [unreadable]..
  24. Development of Sensory/Pain-Selective Local Anesthetics
    Peter Gerner; Fiscal Year: 2006
    ..abstract_text> ..
  25. Clinical and Molecular Evaluation of Cancer Therapy Induced Mucositis
    Sharon Gordon; Fiscal Year: 2007
    ..Demonstration of safety and tolerability will provide a basis to test further this route of administration. Hence, this proposal holds promise for clinical application in a relatively short period. [unreadable] [unreadable]..
  26. SELECTIVE REMOVAL OF EXTRAOCULAR MUSCLE
    Alan Scott; Fiscal Year: 2002
    ..Aim 6 represents human pilot studies needed for design of clinical trials for the therapy developed in this proposal. ..
  27. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  28. PHARMACOLOGY OF CARDIAC SODIUM CHANNEL MODIFIERS
    Michael Sheets; Fiscal Year: 2008
    ..The results of these studies should improve our overall understanding of the molecular mechanisms of anti-arrhythmic drugs modification of cardiac Na channels. [unreadable] [unreadable]..
  29. Role of Segment 6 in Heart Na Channel Slow Inactivation
    John O Reilly; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. VOLATILE ANESTHETICS AND RESPIRATORY NEUROTRANSMISSION
    Eckehard Stuth; Fiscal Year: 2009
    ....
  31. Aging, Increased IL-6, Burn, and Myocardial Depression
    Weike Tao; Fiscal Year: 2008
    ..The proposal will allow the principal investigator to generate data to address the Specific Aims and to allow didactic training necessary for his career development. ..
  32. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..Effective treatment of nausea may substantially improve the quality of life for patients with chronic disease. ..
  33. Phospholipid Nanocarriers Improve Chemotherapy by Targeted Drug Delivery
    Hayat Onyuksel; Fiscal Year: 2010
    ....
  34. TRPV1 Expressing Sensory Afferents in Postoperative Pain
    Timothy Brennan; Fiscal Year: 2009
    ..A separate pathway, likely an A-fiber mediated pathway, is sufficient to transmit the enhanced mechanical responses. ..
  35. Cannabinoid Modulation of Capsaicin-Sensitive Nociceptors
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..Second, identification of cannabinoid modulation of pain via TRPchannels provides a rationale for a novel class of analgesics that are devoid of classical cannabinoid side effects. ..
  36. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  37. Persistent Mechanical Hypersensitivity in Rats: Biobehavioral Effects
    Gayle Page; Fiscal Year: 2009
    ..The relevance of the proposed study to human health is the goal to discern what factors (e.g., sleep disruption, biological responses to stress and anxiety) increase one s risk to develop chronic pain. ..
  38. Treatment of Demyelinating Disease with HSP90 Inhibitors
    Douglas L Feinstein; Fiscal Year: 2010
    ....
  39. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  40. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ....
  41. SPINAL CORD INJURY, METHYLPREDNISOLONE & P GLYCOPROTEIN
    CHRISTOPHER BERNARDS; Fiscal Year: 2002
    ..4. To determine whether increased spinal cord bioavailability of methylprednisolone decreases secondary damage following spinal cord injury. ..
  42. Microbiology/Immunology of Periodontal Disease in T1DM
    Paul Moore; Fiscal Year: 2002
    ..An integrated multidisciplinary effort provides significant data collection capabilities essential for understanding the complex multifactorial etiology of periodontal disease in Type 1 diabetes. ..
  43. DIRECT NEUROTOXICITY OF LOCAL ANESTHETICS
    Michael Johnson; Fiscal Year: 2002
    ..The Ca2+cyt dependence of each mechanism of mitochondrial injury will be determined by experiments with and without Ca2+cyt clamped at a normal level. ..
  44. CONTROL OF FEEDING BEHAVIOR--HEPATIC AFFERENT SIGNALING
    CHARLES HORN; Fiscal Year: 2002
    ..Results from this project may contribute to a better understanding of metabolic stimuli that are sensed by the nervous system, and may elucidate neural controls that are involved in obesity, anorexia, and diabetes. ..
  45. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
  46. PERIOPERATIVE PAIN, IMMUNE FUNCTION, AND METASTASIS
    Gayle Page; Fiscal Year: 2001
    ....
  47. ROLE OF STRETCH-INDUCED COX-2 IN BLADDER CONTRACTILITY
    John Park; Fiscal Year: 2003
    ..Therefore, characterizing the biological role of PG synthetic pathways via COX-2 gene activation in bladder should lead to novel insights in the overall management of painful bladder syndromes. ..
  48. CARDIAC NA+ CHANNEL GATING AND LOCAL ANESTHETIC BLOCK
    STERLING WRIGHT; Fiscal Year: 2004
    ..gating mechanism will be a critical step toward explaining why clinically important local anesthetics, such as bupivacaine and lidocaine, affect cardiac physiology at circulating concentrations that have little effect on skeletal ..
  49. Neurophysiologic Development Responses to Surgery
    DOUGLAS RIRIE; Fiscal Year: 2007
    ..Through this and future studies which come from this data and training, improvement in understanding will hopefully lead to improved pain therapy that is developmentally appropriate. ..
  50. Neuropeptide Y Regulation of Peripheral Human Nociceptors and Pain
    Kenneth Hargreaves; Fiscal Year: 2007
    ..Moreover, our study population in South Texas permits secondary analyses of a potentially underserved population (predominantly Hispanic) that is at risk for caries-induced pulpal necrosis and pain. [unreadable] [unreadable]..
  51. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  52. The role of I-kappaB in control of glial inflammation
    Douglas Feinstein; Fiscal Year: 2006
    ..These experiments will provide targets for therapeutic intervention to reduce pathological NOS2 in brain, and help develop a new animal model for examining brain inflammatory in the context of diminished NE levels. ..
  53. Mechanisms of Nicotine Induced Neurogenic Inflammation
    Kenneth Hargreaves; Fiscal Year: 2005
    ....
  54. Neonatal Pain, Adult Biobehavioral Responses to Stress
    Gayle Page; Fiscal Year: 2005
    ..Findings from these studies will demonstrate possible negative physiologic and behavioral sequelae of repeated painful experiences during neonatal development as well as suggest potential preventive interventions. ..
  55. Evaluation of Biliary Strictures by IDUS, DIA, and FISH
    Michael Levy; Fiscal Year: 2005
    ..Significance: The study results have the potential to significantly improve the accurate diagnosis of biliary strictures. Earlier and more definitive diagnosis will translate into improved treatment options. ..
  56. Activation Gating in Human Heart Na+ Channels
    Sho Ya Wang; Fiscal Year: 2004
    ..Detailed mapping of the cytoplasmic S6 regions along with their linkage with the Na+ channel activation gating may provide insights for the design of new therapeutic drugs that target this important region. ..
  57. ORAL HEALTH OF OLDER TYPE 1 DIABETIC PATIENTS
    Paul Moore; Fiscal Year: 2003
    ..This overall plan will permit us to understand the etiology of these complications and to define specific subpopulations and risk factors appropriate for future prospective oral health prevention and intervention trials. ..
  58. Photodynamic Therapy for the Treatment of Obstructive E*
    Todd Demmy; Fiscal Year: 2007
    ..This proposal will be instrumental in the development of a novel PDT drug without long-term restrictions of patients' sun exposure. [unreadable] [unreadable]..