lidocaine

Summary

Summary: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Top Publications

  1. ncbi Systemic lidocaine for neuropathic pain relief
    J Mao
    MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Pain 87:7-17. 2000
  2. ncbi Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation?
    Hisayoshi Tachihara
    Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
    Spine (Phila Pa 1976) 33:743-7. 2008
  3. ncbi Evaluation of the isoflurane-sparing effects of lidocaine and fentanyl during surgery in dogs
    Paulo V M Steagall
    Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, SP 18618 000, Brazil
    J Am Vet Med Assoc 229:522-7. 2006
  4. ncbi Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
    Alexander M Binshtok
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nature 449:607-10. 2007
  5. ncbi Sustainable release of vancomycin, gentamicin and lidocaine from novel electrospun sandwich-structured PLGA/collagen nanofibrous membranes
    Dave W Chen
    Department of Mechanical Engineering, Chang Gung University, Tao Yuan, Taiwan
    Int J Pharm 430:335-41. 2012
  6. ncbi Molecular determinants of state-dependent block of Na+ channels by local anesthetics
    D S Ragsdale
    Department of Pharmacology, University of Washington, Seattle 98195
    Science 265:1724-8. 1994
  7. ncbi A comparison of articaine and lidocaine for inferior alveolar nerve blocks
    Philip Mikesell
    Department of Endodontics, The Ohio State University, Columbus, OH, USA
    J Endod 31:265-70. 2005
  8. ncbi Fluoroscopic caudal epidural injections with or without steroids in managing pain of lumbar spinal stenosis: one-year results of randomized, double-blind, active-controlled trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY 42003, USA
    J Spinal Disord Tech 25:226-34. 2012
  9. ncbi Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium
    Marco Contreras
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    Science 318:655-8. 2007
  10. ncbi Dupuytren's fasciectomies in 60 consecutive digits using lidocaine with epinephrine and no tourniquet
    Keith Denkler
    Department of Plastic Surgery, University of California, San Francisco, San Francisco, Calif, USA
    Plast Reconstr Surg 115:802-10. 2005

Detail Information

Publications296 found, 100 shown here

  1. ncbi Systemic lidocaine for neuropathic pain relief
    J Mao
    MGH Pain Center, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Pain 87:7-17. 2000
    The effectiveness of systemic lidocaine in relieving acute and chronic pain has been recognized for over 35 years...
  2. ncbi Do corticosteroids produce additional benefit in nerve root infiltration for lumbar disc herniation?
    Hisayoshi Tachihara
    Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
    Spine (Phila Pa 1976) 33:743-7. 2008
    ..Experimental animal study...
  3. ncbi Evaluation of the isoflurane-sparing effects of lidocaine and fentanyl during surgery in dogs
    Paulo V M Steagall
    Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, SP 18618 000, Brazil
    J Am Vet Med Assoc 229:522-7. 2006
    To evaluate the isoflurane-sparing effects of lidocaine and fentanyl administered by constant rate infusion (CRI) during surgery in dogs.
  4. ncbi Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
    Alexander M Binshtok
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nature 449:607-10. 2007
    ..of primary sensory nociceptor (pain-sensing) neurons by introducing the charged, membrane-impermeant lidocaine derivative QX-314 through the pore of the noxious-heat-sensitive TRPV1 channel...
  5. ncbi Sustainable release of vancomycin, gentamicin and lidocaine from novel electrospun sandwich-structured PLGA/collagen nanofibrous membranes
    Dave W Chen
    Department of Mechanical Engineering, Chang Gung University, Tao Yuan, Taiwan
    Int J Pharm 430:335-41. 2012
    This study investigated the in vitro release of vancomycin, gentamicin, and lidocaine from novel electrospun sandwich-structured polylactide-polyglycolide (PLGA)/collagen nanofibrous membranes...
  6. ncbi Molecular determinants of state-dependent block of Na+ channels by local anesthetics
    D S Ragsdale
    Department of Pharmacology, University of Washington, Seattle 98195
    Science 265:1724-8. 1994
    ..The results define the location of the local anesthetic receptor site in the pore of the Na+ channel and identify molecular determinants of the state-dependent binding of local anesthetics...
  7. ncbi A comparison of articaine and lidocaine for inferior alveolar nerve blocks
    Philip Mikesell
    Department of Endodontics, The Ohio State University, Columbus, OH, USA
    J Endod 31:265-70. 2005
    ..was to compare the degree of pulpal anesthesia obtained with 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine in inferior alveolar nerve blocks...
  8. ncbi Fluoroscopic caudal epidural injections with or without steroids in managing pain of lumbar spinal stenosis: one-year results of randomized, double-blind, active-controlled trial
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY 42003, USA
    J Spinal Disord Tech 25:226-34. 2012
    ..A randomized, double-blind, active-controlled trial...
  9. ncbi Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium
    Marco Contreras
    Departamento de Fisiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 6513677, Chile
    Science 318:655-8. 2007
    ..We conclude that the insular cortex is a key structure in the perception of bodily needs that provides direction to motivated behaviors...
  10. ncbi Dupuytren's fasciectomies in 60 consecutive digits using lidocaine with epinephrine and no tourniquet
    Keith Denkler
    Department of Plastic Surgery, University of California, San Francisco, San Francisco, Calif, USA
    Plast Reconstr Surg 115:802-10. 2005
    ..The old dogma against its use in the fingers is refuted, as seen by the results in these 60 consecutive Dupuytren's fasciectomies and the results of other authors...
  11. ncbi Lidocaine-induced cell death in a human model of neuronal apoptosis
    P Friederich
    Universitätsklinik Eppendorf, Department of Anaesthesiology, Centre for Molecular Neurobiology, Hamburg, Germany
    Eur J Anaesthesiol 19:564-70. 2002
    Clinical studies suggest that lidocaine may induce irreversible neurological damage after spinal application in human beings...
  12. ncbi Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion
    Stephanie K Dix
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Crit Care Med 39:872-4. 2011
    Demonstrate a case report involving successful use of lipid emulsion therapy for intractable cardiac arrest due to lidocaine toxicity.
  13. ncbi Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling
    Robert Werdehausen
    Department of Anesthesiology, University of Dusseldorf, Dusseldorf, Germany
    Anesthesiology 107:136-43. 2007
    Local anesthetics, especially lidocaine, can lead to persistent cauda equina syndrome after spinal anesthesia. Recently, lidocaine has been reported to trigger apoptosis, although the underlying mechanisms remain unknown...
  14. ncbi The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain
    S Abdi
    Department of Anesthesiology and Critical Care, The Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Anesth Analg 87:1360-6. 1998
    ..regarding the acute effects of the commonly used adjuvant drugs amitriptyline (AMI), gabapentin (GBP), and lidocaine (LDC) on neuropathic pain behaviors in animal models...
  15. ncbi Local anesthetic sciatic nerve block and nerve fiber damage in diabetic rats
    Jeffrey S Kroin
    Department of Anesthesiology, Rush University Medical Center, Chicago, IL 60612, USA
    Reg Anesth Pain Med 35:343-50. 2010
    ..A previous study in streptozotocin-induced diabetic rats showed that larger doses of lidocaine produce moderate nerve injury after nerve block in normal rats and worse injury in diabetic rats...
  16. pmc Systemic lidocaine shortens length of hospital stay after colorectal surgery: a double-blinded, randomized, placebo-controlled trial
    Susanne Herroeder
    Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands
    Ann Surg 246:192-200. 2007
    To characterize the beneficial effects of perioperative systemic lidocaine on length of hospital stay, gastrointestinal motility, and the inflammatory response after colorectal surgery.
  17. ncbi Comparative study of the anesthetic efficacy of 4% articaine versus 2% lidocaine in inferior alveolar nerve block during surgical extraction of impacted lower third molars
    Alejandro Sierra Rebolledo
    University of Barcelona Dental School, Barcelona, Spain
    Med Oral Patol Oral Cir Bucal 12:E139-44. 2007
    A comparative study is made of the anesthetic efficacy of 4% articaine versus 2% lidocaine, both with epinephrine 1:100,000, in truncal block of the inferior alveolar nerve during the surgical extraction of impacted lower third molars.
  18. ncbi Comparison of the degree of pulpal anesthesia achieved with the intraosseous injection and infiltration injection using 2% lidocaine with 1:100,000 epinephrine
    John Nusstein
    Department of Endodontics, The Ohio State University, Columbus, USA
    Gen Dent 53:50-3. 2005
    ..degree of pulpal anesthesia obtained from an intraosseous injection to an infiltration injection that used 2% lidocaine with 1:100,000 epinephrine...
  19. ncbi Greater occipital nerve injection in primary headache syndromes--prolonged effects from a single injection
    S K Afridi
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Pain 122:126-9. 2006
    ..It is remarkable that in all conditions in which an effect is observed the response time so much exceeds the local anesthetic effect that the mechanism of action may well be through changes in brain nociceptive pathways...
  20. ncbi Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis
    Ivo W Tremont-Lukats
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Anesth Analg 101:1738-49. 2005
    ..Of 41 retrieved studies, 27 trials of diverse quality were included in the systematic review. Ten lidocaine and nine mexiletine trials had data suitable for meta-analysis (n = 706 patients total)...
  21. ncbi Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Erlangen, Germany
    Anesth Analg 98:1050-5, table of contents. 2004
    ..in this study was to determine the time course of the analgesic and antihyperalgesic mechanisms of perioperative lidocaine administration...
  22. ncbi Comparison of 0.5% levobupivacaine, 0.5% bupivacaine, and 2% lidocaine for retrobulbar anesthesia in vitreoretinal surgery
    Recep Aksu
    Department of Anesthesiology, Erciyes University School of Medicine, Kayseri Turkey
    Eur J Ophthalmol 19:280-4. 2009
    The authors compared the efficacy of local anesthetics levobupivacaine, bupivacaine, and lidocaine for retrobulbar anesthesia in vitreoretinal surgery.
  23. ncbi Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system
    Uta Muth-Selbach
    Department of Anesthesiology, University of Duesseldorf, Germany
    Eur J Pharmacol 613:68-73. 2009
    ..The antinociceptive effect of lidocaine is well documented, yet the exact mechanism is not fully understood...
  24. ncbi The effect of lidocaine on the globule size distribution of propofol emulsions
    Jong Woo Park
    Department of Pharmaceutics, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea
    Anesth Analg 97:769-71. 2003
    In this study, we sought to determine the globule size distribution of a propofol/lidocaine mixture as a function of lidocaine concentration and time elapsed after mixing in a standard formulation of propofol emulsion (Diprivan) and in a ..
  25. ncbi Heated lidocaine/tetracaine patch (Synera, Rapydan) compared with lidocaine/prilocaine cream (EMLA) for topical anaesthesia before vascular access
    J Sawyer
    Prism Ideas Ltd, Regent House Princes Court, Beam Heath Way, Nantwich, Chesire CW5 7PQ, UK
    Br J Anaesth 102:210-5. 2009
    We compared the lidocaine/tetracaine patch [Synera (USA), Rapydan (Europe)], a novel heat-aided patch using a eutectic mixture of lidocaine 70 mg and tetracaine 70 mg, with a eutectic mixture of lidocaine 25 mg ml(-1) and prilocaine 25 ..
  26. ncbi In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1456-64, table of contents. 2008
    ..show us that specific activation of the p38 mitogen-activated protein kinase (MAPK) may be a pivotal step in lidocaine neurotoxicity, but this has not been investigated in the case of two very widely used local anesthetics, ..
  27. ncbi 5% lidocaine medicated plaster versus pregabalin in post-herpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study
    Ralf Baron
    Division of Neurological Pain Research and Therapy, Department of Neurology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel, Germany
    Curr Med Res Opin 25:1663-76. 2009
    To compare efficacy and safety of 5% lidocaine medicated plaster with pregabalin in patients with post-herpetic neuralgia (PHN) or painful diabetic polyneuropathy (DPN).
  28. ncbi Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster
    Bryan J Campbell
    Division of Drug Delivery and Disposition, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Pharm Sci 91:1343-50. 2002
    Topical lidocaine has been recently marketed as a new treatment for post-herpetic neuralgia...
  29. ncbi Efficacy and tolerability of a 5% lidocaine medicated plaster for the topical treatment of post-herpetic neuralgia: results of a long-term study
    Guy Hans
    Multidisciplinary Pain Center PCT, Antwerp University Hospital UZA, Edegem, Belgium
    Curr Med Res Opin 25:1295-305. 2009
    Evaluation of long-term efficacy and safety of the 5% lidocaine medicated plaster for neuropathic pain symptoms in patients with post-herpetic neuralgia (PHN).
  30. ncbi Intranasal lidocaine for cluster headache
    L Robbins
    Robbins Headache Clinic, Northbrook, Illinois, USA
    Headache 35:83-4. 1995
    Thirty male patients with cluster headache were given 4% lidocaine solution to use intranasally as an abortive therapy. Four sprays of lidocaine were used ipsilateral to the pain, and two more were used, if necessary...
  31. ncbi Topical anesthetics update: EMLA and beyond
    P M Friedman
    Derm Surgery Associates, Houston, Texas 77030, USA
    Dermatol Surg 27:1019-26. 2001
    ..EMLA is the most commonly used agent, however, several new topical anesthetic agents have been released recently that claim increased efficacy and a faster onset of action...
  32. ncbi A single injection of lidocaine as local anesthesia for ultrasound guided needle biopsy of the prostate
    Gianluigi Taverna
    Department of Urology, Istituto Clinico Humanitas, Rozzano Milan, Italy
    J Urol 167:222-3. 2002
    We evaluated the effectiveness of a single injection of lidocaine on patient tolerance of multiple needle biopsies of the prostate.
  33. ncbi Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels
    Christopher A Ahern
    Department of Molecular Physiology and Biophysics, Institute of Hyperexcitability, Jefferson Medical College, Philadelphia, PA, USA
    Circ Res 102:86-94. 2008
    ..We tested whether channel inhibition was facilitated by an electrostatic attraction between lidocaine and pi electrons of the aromatic rings of these residues, namely a cation-pi interaction...
  34. ncbi Symptom profiles differ in patients with neuropathic versus non-neuropathic pain
    Robert H Dworkin
    Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Pain 8:118-26. 2007
    ..These assessments were conducted before treatment had begun in clinical trials of lidocaine patch 5% administered alone or with stable dosages of other analgesics...
  35. ncbi Prolonged relief of neuralgia after regional anesthetic blocks. A call for further experimental and systematic clinical studies
    S Arner
    Dept of Anesthesiology and Intensive Care, Karolinska Hospital, Stockholm, Sweden
    Pain 43:287-97. 1990
    ..To test this hypothesis, an experimental study with [3H]lidocaine was performed in 6 rats...
  36. ncbi A microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug
    Morten Bagger
    Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Int J Pharm 269:311-22. 2004
    ..for olfactory drug absorption has been investigated using intravenous and unilateral nasal administration of lidocaine hydrochloride in rats...
  37. ncbi Lidocaine inhibits epithelial chemokine secretion via inhibition of nuclear factor kappa B activation
    Alon Lang
    Department of Gastroenterology, Chaim Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    Immunobiology 215:304-13. 2010
    To study the antiinflammatory effect of lidocaine in intestinal epithelial cells.
  38. pmc Modulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection
    Mohammed Aldakkak
    Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 54:298-309. 2009
    ..We tested if hyperkalemic cardioplegia (CP) and lidocaine (LID) differently modulate mitochondrial (m) bioenergetics and protect hearts against I/R injury...
  39. ncbi Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia
    Mikito Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Hokkaido, Japan
    Pain 100:77-89. 2002
    ..In experiment 1, the subjects (n=8) were administered lidocaine systemically (a bolus injection of 2mg/kg for a period of 5 min followed by an intravenous infusion of 2mg/kg/h ..
  40. pmc Formulation and evaluation of lidocaine lipid nanosystems for dermal delivery
    Pankaj Pathak
    Department of Pharmaceutics, Bombay College of Pharmacy, Sundernagar, Kalina, Santacruz East, Mumbai 400098, India
    AAPS PharmSciTech 10:985-92. 2009
    ..SLN) and nanostructured lipid carriers (NLC) for improving the dermal delivery of a local anesthetic agent lidocaine (LID)...
  41. ncbi Sustained delivery of lidocaine into the cochlea using poly lactic/glycolic acid microparticles
    Rie T Horie
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Laryngoscope 120:377-83. 2010
    b>Lidocaine is a local anesthetic that is known to suppress tinnitus via systemic or local application; however, this effect has only limited duration...
  42. ncbi Lidocaine 4% cream compared with lidocaine 2.5% and prilocaine 2.5% or dorsal penile block for circumcision
    Victoria Tutag Lehr
    Department of Pharmacy Practice, The Eugene Applebaum College of Pharmacy and Health Sciences, Pediatric Pharmacology Research Unit, Children s Hospital of Michigan, Detroit, Michigan 48201, USA
    Am J Perinatol 22:231-7. 2005
    This study evaluated the efficacy and safety of lidocaine 4% cream (LMX4), compared with lidocaine 2.5% and prilocaine 2.5% (EMLA) or dorsal penile block (DPNB) for analgesia during circumcision...
  43. pmc A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity
    Patrick L Sheets
    Department of Pharmacology and Toxicology, Stark Neurosciences Research Institute, Indiana University School of Medicine, 950 West Walnut St, R2 468, Indianapolis, IN 46202, USA
    J Physiol 581:1019-31. 2007
    ..can be difficult to treat and, although sodium channels are targeted by local anaesthetics such as lidocaine (lignocaine), some patients do not respond to treatment with local anaesthetics...
  44. ncbi Randomized double-blind comparison of lidocaine gel and plain lubricating gel in relieving pain during flexible cystoscopy
    Yung Tai Chen
    Department of Urology, Taiwan Adventist Hospital, Taiwan
    J Endourol 19:163-6. 2005
    To compare the pain induced by outpatient flexible cystoscopy in men having local lidocaine jelly application or plain lubricant.
  45. ncbi The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine
    S M Trailović
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Bulevar JA 18, Belgrade 11000, Serbia and Montenegro
    Vet Res Commun 31:863-72. 2007
    ..more than one mechanism; therefore, the anticonvulsive effect of ivermectin against convulsions caused by lidocaine and strychnine was evaluated...
  46. ncbi Effect of intravenous lidocaine and ketamine on the minimum alveolar concentration of isoflurane in goats
    Tom Doherty
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Vet Anaesth Analg 34:125-31. 2007
    To evaluate the effects of i.v. lidocaine (L) and ketamine (K), alone and in combination (LK), on the minimum alveolar concentration (MAC) of isoflurane (ISO) in goats.
  47. ncbi Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: insights into the development of cell-based pacemakers
    Tian Xue
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Circulation 111:11-20. 2005
    ..Although CMs can be derived from hESCs ex vivo, it remains uncertain whether a functional syncytium can be formed between donor and recipient cells after engraftment...
  48. pmc Lidocaine down-regulates nuclear factor-kappaB signalling and inhibits cytokine production and T cell proliferation
    A Lahat
    Department of Gastroenterology, Chaim Sheba Medical Center affiliated with the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Exp Immunol 152:320-7. 2008
    b>Lidocaine is a commonly used local anaesthetic agent which has also been found to possess anti-inflammatory activity in several disorders. However, the mechanism of this effect has been little explored...
  49. ncbi Spray-as-you-go airway topical anesthesia in patients with a difficult airway: a randomized, double-blind comparison of 2% and 4% lidocaine
    Fu S Xue
    Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Ba Da Chu Rd, Shi Jing Shan District, Beijing, People s Republic of China 100144
    Anesth Analg 108:536-43. 2009
    We designed this randomized, double-blind clinical study to compare the safety and efficacy of 2% and 4% lidocaine during airway topical anesthesia with a spray-as-you-go technique via the fiberoptic bronchoscope.
  50. ncbi Caudal epidural block for minor gynecologic procedures in outpatient surgery
    Shu Yam Wong
    Department of Anesthesiology, Chang Gung Memorial Hospital, Taipei, Taiwan 333, ROC
    Chang Gung Med J 27:116-21. 2004
    ..The aim of this study was to verify whether CEB could be applied as a simple, safe and economic method of anesthesia for adult patients undergoing minor gynecologic procedures (MGP)...
  51. ncbi The effects of intravenous lidocaine administration on the minimum alveolar concentration of isoflurane in cats
    Bruno H Pypendop
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA
    Anesth Analg 100:97-101. 2005
    b>Lidocaine decreases the minimum alveolar concentration (MAC) of inhaled anesthetics and has been used clinically to reduce the requirements for other anesthetic drugs...
  52. ncbi Systemic lidocaine in pain due to peripheral nerve injury and predictors of response
    N Attal
    INSERM E 332, Centre d Evaluation et de Traitement de la Douleur, Hopital Ambroise Pare, AP HP, and Université Versailles Saint Quentin, France
    Neurology 62:218-25. 2004
    To investigate the effects of IV lidocaine on spontaneous and evoked pain (allodynia and hyperalgesia) due to peripheral nerve injury (postherpetic neuralgia or nerve trauma) using quantitative sensory testing.
  53. ncbi Dexamethasone attenuated bupivacaine-induced neuron injury in vitro through a threonine-serine protein kinase B-dependent mechanism
    R Ma
    Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, PR China
    Neuroscience 167:329-42. 2010
    ..We also investigated whether dexamethasone could prevent lidocaine-induced neurotoxicity...
  54. ncbi Intracervical lidocaine gel for intrauterine device insertion: a randomized controlled trial
    Karla Maguire
    Department of Obstetrics and Gynecology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Contraception 86:214-9. 2012
    ..One study suggested that 2% lidocaine gel decreased pain; however, study design problems limit its validity (Brit J Fam Plann 1996;22:177-180)...
  55. ncbi The influence of propofol, remifentanil and lidocaine on the tone of human bronchial smooth muscle
    Paola Rogliani
    Department of System Medicine, University of Rome Tor Vergata, Rome, Italy
    Pulm Pharmacol Ther 26:325-31. 2013
    Bronchoscopy is generally a safe procedure, but the induction of anaesthesia can induce bronchospasm. Consequently we investigated the influence of propofol, remifentanil and lidocaine on the tone of the human bronchial smooth muscle.
  56. ncbi Lidocaine-loaded non-ionic surfactant vesicles: characterization and in vitro permeation studies
    M Carafa
    Faculty of Pharmacy, University of Rome La Sapienza, P le A Moro 5, 00185, Rome, Italy
    Int J Pharm 231:21-32. 2002
    Our research on topical application of lidocaine-loaded non-ionic surfactant vesicles (NSVs) was prompted by the great interest on new delivery systems for local anaesthetics...
  57. ncbi Effects of lidocaine constant rate infusion on sevoflurane requirement, autonomic responses, and postoperative analgesia in dogs undergoing ovariectomy under opioid-based balanced anesthesia
    Nicolò Columbano
    Dipartimento di Patologia e Clinica Veterinaria, Sezione di Clinica Chirurgica Veterinaria, Facolta di Medicina Veterinaria, Universita degli Studi di Sassari, I 07100 Sassari, Italy
    Vet J 193:448-55. 2012
    The effects of constant rate infusion (CRI) of lidocaine on sevoflurane (SEVO) requirements, autonomic responses to noxious stimulation, and postoperative pain relief were evaluated in dogs undergoing opioid-based balanced anesthesia...
  58. ncbi Bacterial cellulose membranes applied in topical and transdermal delivery of lidocaine hydrochloride and ibuprofen: in vitro diffusion studies
    Eliane Trovatti
    CICECO and Department of Chemistry, University of Aveiro, 3810 193 Aveiro, Portugal
    Int J Pharm 435:83-7. 2012
    ..To assess its therapeutic feasibility, the permeation through human epidermis of two model drugs (lidocaine hydrochloride and ibuprofen) in BC and other formulation systems was compared in vitro...
  59. ncbi A smaller endotracheal tube combined with intravenous lidocaine decreases post-operative sore throat - a randomized controlled trial
    Y J Xu
    Department of Anesthesiology, Fudan University, Shanghai Cancer Center, Shanghai, China
    Acta Anaesthesiol Scand 56:1314-20. 2012
    ..We conducted a trial to evaluate the effect of non-pharmacological [smaller-sized endotracheal tube (ETT)] combined with pharmacological intervention [lidocaine intravenous (i.v.)] on POST in women undergoing thyroid surgery.
  60. pmc Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review
    Melanie Plested
    Heron Evidence Development Ltd, Butterfield Technology Park, Luton, UK
    BMC Neurol 10:116. 2010
    ..The aim of this study was to identify published data for three pharmacological treatments: pregabalin, lidocaine plaster, and duloxetine, which are typically used at 2(nd) line or later in UK patients with neuropathic pain.
  61. pmc Cervical lidocaine for IUD insertional pain: a randomized controlled trial
    Colleen P McNicholas
    Division of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Am J Obstet Gynecol 207:384.e1-6. 2012
    Anticipated pain with intrauterine device (IUD) insertion may be a barrier to widespread use. Our objective was to evaluate the efficacy of intracervical 2% lidocaine gel for pain relief with IUD insertion.
  62. ncbi Penetration enhancement of lidocaine hydrochlorid by a novel chitosan coated elastic liposome for transdermal drug delivery
    Lingling Li
    Key Laboratory of Nanobiological Technology, Ministry of Health National Hepatobiliary and Enteric Surgery Research Center, Central South University, Changsha, Hunan 410008, P R China
    J Biomed Nanotechnol 7:704-13. 2011
    An effective transdermal delivery system for local anaesthetic was developed with lidocaine hydrochloride (LID) as model drug...
  63. ncbi Lidocaine-derivative JMF2-1 prevents ovalbumin-induced airway inflammation by regulating the function and survival of T cells
    P C Olsen
    Laboratory of Inflammation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    Clin Exp Allergy 41:250-9. 2011
    Inhalation of the local anaesthetic lidocaine has been suggested to be beneficial for asthmatics, but airway anaesthesia is unpleasant and may exacerbate bronchoconstriction...
  64. pmc Analysis of the action of lidocaine on insect sodium channels
    Weizhong Song
    Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, 106 CIPS, East Lansing, MI 48824, USA
    Insect Biochem Mol Biol 41:36-41. 2011
    ..In this study, we examined the effects of lidocaine on a cockroach sodium channel variant, BgNa(v)1-1a, and determined whether F1817 and Y1824 are also critical for ..
  65. ncbi Long-term treatment of neuropathic pain with a 5% lidocaine medicated plaster
    Ilca Ricarda Wilhelm
    Department of Anaesthesiology, University Hospital Erlangen, Erlangen, Germany
    Eur J Anaesthesiol 27:169-73. 2010
    The 5% lidocaine medicated plaster is a topical treatment for peripheral neuropathic pain symptoms (e.g. burning, shooting and stabbing pain) and is registered for the treatment of postherpetic neuralgia...
  66. ncbi A prospective, randomized, double-blind comparison of articaine and lidocaine for maxillary infiltrations
    Grace Evans
    Division of Endodontics, The Ohio State University, Columbus, USA
    J Endod 34:389-93. 2008
    ..crossover study was to evaluate the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine and 2% lidocaine with 1:100,000 epinephrine in maxillary lateral incisors and first molars...
  67. ncbi Can intravenous lidocaine decrease postsurgical ileus and shorten hospital stay in elective bowel surgery? A pilot study and literature review
    Kyle P Harvey
    Department of Surgery, St Joseph Mercy Oakland Hospital, Pontiac, MI, USA
    Am J Surg 198:231-6. 2009
    This study examined whether systemic infusion of lidocaine, a local anesthetic with anti-inflammatory properties, can decrease surgical pain, length of postsurgical ileus, and hospital stay.
  68. ncbi 5% lidocaine medicated plaster in elderly patients with postherpetic neuralgia: results of a compassionate use programme in France
    Florentin Clère
    Centre Hospitalier, Consultation Pluridisciplinaire de la Douleur, Chateauroux, France
    Drugs Aging 28:693-702. 2011
    ..PHN prevalence increases with advancing age. One treatment option is the topical analgesic 5% lidocaine (lignocaine) medicated plaster (Versatis®), which has been proven to be efficacious and well tolerated in a ..
  69. ncbi Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy
    Abdourahamane Kaba
    Department of Anesthesia and Intensive Care Medicine, Centre Hospitalier Universitaire CHU de Liège, University of Liege, Belgium
    Anesthesiology 106:11-8; discussion 5-6. 2007
    Intravenous infusion of lidocaine decreases postoperative pain and speeds the return of bowel function...
  70. pmc Pain quality predicts lidocaine analgesia among patients with suspected neuropathic pain
    Ian R Carroll
    Stanford University School of Medicine, 780 Welch Rd Suite 208E, Palo Alto, CA 94040, USA
    Pain Med 11:617-21. 2010
    ..We hypothesized that differing baseline pain qualities (e.g. "stabbing" vs "dull") might define specific subgroups responsive to intravenous (IV) lidocaine-a potent sodium channel blocker.
  71. ncbi A comparison between articaine HCl and lidocaine HCl in pediatric dental patients
    S F Malamed
    School of Dentistry, University of Southern California, USA
    Pediatr Dent 22:307-11. 2000
    ..were conducted to compare the safety and efficacy of articaine HCl (4% with epinephrine 1:100,000) to that of lidocaine HCl (2% with epinephrine 1:100,000) in patients aged 4 years to 79 years, with subgroup analysis on subjects 4 ..
  72. ncbi A randomized, double-masked, placebo-controlled pilot trial of extended IV lidocaine infusion for relief of ongoing neuropathic pain
    Ivo W Tremont-Lukats
    Department of Neurology, University of Wisconsin Madison, Madison, WI 53792, USA
    Clin J Pain 22:266-71. 2006
    To determine the dose-response effect and safety of IV lidocaine at different dose infusion rates on spontaneous ongoing neuropathic pain.
  73. ncbi Comparison of articaine and bupivacaine/lidocaine for sub-Tenon's anaesthesia in cataract extraction
    P Gouws
    West of England Eye Unit, Royal Devon and Exeter Hospital, Barrack Road, Exeter EX2 5DW, UK
    Br J Anaesth 92:228-30. 2004
    ..We have previously shown articaine to be superior to a standard mixture of bupivacaine 0.5%/lidocaine 2% for peribulbar anaesthesia...
  74. ncbi Topical amitriptyline versus lidocaine in the treatment of neuropathic pain
    Kok Yuen Ho
    Department of Anaesthesia and Surgical Intensive Care, Singapore General Hospital, Singapore
    Clin J Pain 24:51-5. 2008
    ..We conducted a double-blind, randomized, placebo-controlled crossover study to evaluate the efficacy of topical 5% amitriptyline and 5% lidocaine in treating patients with neuropathic pain.
  75. ncbi Effect of systemic lidocaine on visceral and somatic nociception in conscious horses
    S A Robertson
    Island Whirl Equine Colic Research Laboratory, Department of Large Animal Clinical Sciences, University of Florida, College of Veterinary Medicine, Gainesville, Florida 32610 0136, USA
    Equine Vet J 37:122-7. 2005
    ..Commonly used analgesics (nonsteroidal anti-inflammatory agents, opioids and alpha2-agonists) have unwanted side effects. An effective alternative with minimal adverse effects would benefit clinical equine pain management...
  76. ncbi The efficacy and safety of articaine versus lignocaine in dental treatments: a meta-analysis
    Vandana Katyal
    School of Public Health, University of Sydney, Sydney NSW 2006, Australia
    J Dent 38:307-17. 2010
    ..The aim of this systematic review was to compare the efficacy and safety of articaine with lignocaine in maxillary and mandibular infiltrations and block anaesthesia in patients presenting for routine dental treatments...
  77. pmc Sodium channel molecular conformations and antiarrhythmic drug affinity
    Michael F Sheets
    University of Utah, The Nora Eccles Harrison Cardiovascular Research and Teaching Institute, Department of Internal Medicine, Salt Lake City, UT 84112, USA
    Trends Cardiovasc Med 20:16-21. 2010
    Class I cardiac antiarrhythmic drugs, for example, lidocaine, mexiletine, flecainide, quinidine, and procainamide, continue to play an important role in the therapy for cardiac arrhythmias because of the presence of use-dependent block...
  78. ncbi Mechanically induced axon reflex and hyperalgesia in human UV-B burn are reduced by systemic lidocaine
    Wolfgang Koppert
    Department of Anesthesiology, University of Erlangen, Germany
    Eur J Pain 8:237-44. 2004
    ..In a cross-over double blind design (n = 10), low dose of systemic lidocaine suppressed mechanical hyperalgesia in sunburned skin and in the mechanically induced flare...
  79. pmc A prospective randomized double-blinded pilot study to examine the effect of botulinum toxin type A injection versus Lidocaine/Depomedrol injection on residual and phantom limb pain: initial report
    Hong Wu
    Department of Physical Medicine and Rehabilitation, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clin J Pain 28:108-12. 2012
    ..Botulinum toxin type A (Botox) injection has been used to manage pain. However, it remains to be proved whether Botox injection is effective to relieve residual limb pain (RLP) and phantom limb pain (PLP)...
  80. ncbi The critical role of concentration for lidocaine block of peripheral nerve in vivo: studies of function and drug uptake in the rat
    Tadashi Nakamura
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Anesthesiology 99:1189-97. 2003
    ..This study examines the lidocaine dosage requirement, in milligrams, for functionally assayed sciatic nerve block in the rat using a fourfold ..
  81. ncbi Intra-hippocampal lidocaine injections impair acquisition of a place task and facilitate acquisition of a response task in rats
    Qing Chang
    Department of Psychology, University of Illinois at Urbana Champaign, 603 East Daniel Street, Champaign, IL 61820, USA
    Behav Brain Res 144:19-24. 2003
    ..The present experiment examines the effects of inactivation of the hippocampus with lidocaine prior to learning, to find food in a place or response version of a four-arm plus-shaped maze...
  82. ncbi Systemic lidocaine inhibits remifentanil-induced hyperalgesia via the inhibition of cPKCgamma membrane translocation in spinal dorsal horn of rats
    Weihua Cui
    Department of Anesthesia, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing Institute for Neuroscience, Capital Medical University, Beijing 100069, PR China
    J Neurosurg Anesthesiol 21:318-25. 2009
    ..to determine the involvement of conventional protein kinase Cgamma (cPKCgamma) in the inhibitory action of lidocaine on remifentanil-induced hyperalgesia of rats after propofol-remifentanil-based anesthesia...
  83. ncbi Comparison of anesthetic efficacy of 4% articaine and 2% lidocaine for maxillary buccal infiltration in patients with irreversible pulpitis
    Narasimhan Srinivasan
    Department of Conservative Dentistry, Tamilnadu Government Dental College and Hospital, Chennai 3, India
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:133-6. 2009
    ..this prospective, randomized, double-blind study was to compare the anesthetic efficacy of 4% articaine and 2% lidocaine (both with 1:100,000 epinephrine) for buccal infiltration in patients experiencing irreversible pulpitis in ..
  84. ncbi Trigeminal neuropathic pain in a patient with progressive facial hemiatrophy (parry-romberg syndrome)
    Michele Viana
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 1675, USA
    Arch Neurol 68:938-43. 2011
    ..We reviewed the literature on published cases of progressive facial hemiatrophy (Parry-Romberg syndrome) to identify possible pathophysiological mechanisms of the syndrome...
  85. ncbi Enhanced sensory relearning after nerve repair by using repeated forearm anaesthesia: aspects on time dynamics of treatment
    G Lundborg
    Department of Clinical Sciences Hand Surgery, Malmo University Hospital, Malmo, Sweden
    Acta Neurochir Suppl 100:121-6. 2007
    ..In healthy individuals selective anaesthesia of the forearm results in improved hand sensation. Here we hypothesised that this principle would be valid also after nerve injury and repair...
  86. ncbi Comparison of articaine and lidocaine for infiltration anaesthesia in patients undergoing bone marrow aspiration and biopsy
    Anna Maria Kuivalainen
    Department of Anaesthesiology and Intensive Care Medicine, University of Helsinki, Post Box 20, FIN 00014 Helsinki, Finland
    Eur J Pain 14:160-3. 2010
    ..anaesthesia with articaine, a local anaesthetic able to penetrate bone, may relieve procedural pain better than lidocaine in bone marrow aspiration and biopsy...
  87. pmc Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects
    He Liu
    Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, China
    PLoS ONE 6:e29395. 2011
    ....
  88. ncbi Pharmacokinetics and safety of continuously applied lidocaine patches 5%
    Arnold R Gammaitoni
    Endo Pharmaceuticals Inc, 100 Painters Drive, Chadds Ford, PA 19317, USA
    Am J Health Syst Pharm 59:2215-20. 2002
    The pharmacokinetics, safety, and tolerability of four topical lidocaine patches 5% continuously applied for 72 hours and changed every 12 or 24 hours were examined...
  89. ncbi Synthesis of lidocaine-loaded PLGA microparticles by flow focusing. Effects on drug loading and release properties
    M A Holgado
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González 2, Seville, Spain
    Int J Pharm 358:27-35. 2008
    In the present work, two methods for the preparation of lidocaine-loaded PLGA microparticles are compared...
  90. ncbi Efficacy of articaine formulations: quantitative reviews
    Kellie Paxton
    Dent Clin North Am 54:643-53. 2010
    ..Articaine has been commonly compared with its predecessor, lidocaine hydrochloride...
  91. ncbi Protocol for evaluation of the comparative effectiveness of percutaneous adhesiolysis and caudal epidural steroid injections in low back and/or lower extremity pain without post surgery syndrome or spinal stenosis
    Laxmaiah Manchikanti
    Pain Management Center of Paducah, Paducah, KY, USA
    Pain Physician 13:E91-E110. 2010
    ....
  92. ncbi Comparison of a bupivacaine 0.5% and lidocaine 2% mixture with levobupivacaine 0.75% and ropivacaine 1% in peribulbar anaesthesia for cataract surgery with phacoemulsification
    Mehmet Borazan
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Acta Ophthalmol Scand 85:844-7. 2007
    To compare a bupivacaine and lidocaine mixture with levobupivacaine and ropivacaine in terms of safety, efficacy and blocking quality in peribulbar anaesthesia for phacoemulsification.
  93. ncbi Lidocaine/tetracaine medicated plaster: in minor dermatological and needle puncture procedures
    Jamie D Croxtall
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:2113-20. 2010
    The lidocaine/tetracaine medicated plaster comprises a lidocaine/tetracaine 70 mg/70 mg patch and a controlled heat-assisted drug delivery pod that increases the diffusion of lidocaine and tetracaine into the dermis...
  94. ncbi An investigation of changes in physical properties of injectable calcium hydroxylapatite in a carrier gel when mixed with lidocaine and with lidocaine/epinephrine
    Mariano Busso
    University of Miami, Coral Gables, Florida, USA
    Dermatol Surg 34:S16-23; discussion S24. 2008
    ....
  95. ncbi Dexamethasone added to lidocaine prolongs axillary brachial plexus blockade
    Ali Movafegh
    Department of Anesthesiology and Critical Care, Dr Ali Shariati Hospital, Tehran, Iran
    Anesth Analg 102:263-7. 2006
    ..We designed a prospective, randomized, double-blind study to evaluate the effect of dexamethasone added to lidocaine on the onset and duration of axillary brachial plexus block...
  96. ncbi Prolonged suppression of postincisional pain by a slow-release formulation of lidocaine
    Chi Fei Wang
    Tufts School of Medicine, Boston, Massachusetts, USA
    Anesthesiology 114:135-49. 2011
    ..Here we tested Xybrex (Orthocon, Inc., Irvington, NY), a slow-release formulation of lidocaine that blocks rat sciatic nerve for 1-2 days, for its ability to suppress postincisional pain.
  97. ncbi European evaluation of a new hyaluronic acid filler incorporating lidocaine
    Gregor Wahl
    J Cosmet Dermatol 7:298-303. 2008
    A new dermal filler has been developed with preincorporated lidocaine for the treatment of moderate/severe wrinkles.
  98. ncbi Suppression of cough during emergence from general anesthesia: laryngotracheal lidocaine through a modified endotracheal tube
    C A Diachun
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    J Clin Anesth 13:447-51. 2001
    ..To ascertain if coughing during emergence from general anesthesia can be suppressed with a modified endotracheal tube...
  99. ncbi A comparison of ketamine and lidocaine spray with propofol for the insertion of laryngeal mask airway in children: a double-blinded randomized trial
    Jae Hyon Bahk
    Department of Anesthesiology and Clinical Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Korea
    Anesth Analg 95:1586-9, table of contents. 2002
    ..In this double-blinded, randomized study, we examined whether pretreatment with lidocaine spray, ketamine anesthesia, and LMA insertion could be used as airway management that could maintain spontaneous ..
  100. ncbi Use of buffered lidocaine in bone marrow biopsies: a randomized, controlled trial
    Tracy A Ruegg
    Ohio State University s Arthur G James Cancer Hospital and Richard J Solove Research Institute, Columbus, Ohio, USA
    Oncol Nurs Forum 36:52-60. 2009
    ..perceived pain during preprocedure anesthetic injection for bone marrow biopsy between buffered and unbuffered lidocaine, to determine whether pain levels change over time, and to investigate relationships between perceived pain ..
  101. ncbi Prevention of pain due to injection of propofol with IV administration of lidocaine 40 mg + metoclopramide 2.5, 5, or 10 mg or saline: a randomized, double-blind study in Japanese adult surgical patients
    Yoshitaka Fujii
    First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan
    Clin Ther 29:856-61. 2007
    ..MET also has local anesthetic properties similar to those of LID...

Research Grants65

  1. Neurobiological mechanisms of nicotine reinforcement: Role of the nucleus tractus
    LUIS MIGUEL TUESTA; Fiscal Year: 2012
    ..Preliminary data show that lidocaine-mediated NTS inactivation significantly reduces intravenous nicotine self-administration (IVSA) in rats...
  2. Peripheral and Central Mechanisms of Fatigue and Pain in Patients with ME/CFS
    Roland Staud; Fiscal Year: 2013
    ..For this purpose we will use placebo controlled lidocaine injections into several muscle groups to reduce ERGO activity and thus ongoing fatigue and pain of ME/CFS ..
  3. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    ..blocking drugs can be targeted selectively to nociceptors by co-applying a permanently charged derivative of lidocaine (QX- 314) with capsaicin, an agonist for TRPV1 channels...
  4. Mechanisms of Spontaneous Neuropathic Pain
    Frank Porreca; Fiscal Year: 2013
    ..We have recently demonstrated that microinjection of lidocaine into an area of the brain that mediates descending modulation of pain (i.e...
  5. Volatile anesthetic effects on aging brain
    Zhiyi Zuo; Fiscal Year: 2013
    ..This detrimental effect on old rats was attenuated by intravenous lidocaine, a local anesthetic that has anti-inflammatory property...
  6. Intra-Oral drug-eluting adhesive film
    Haesun Park; Fiscal Year: 2011
    ..adhesive film which can cover and protect various mouth sores and deliver low doses of pain relieving lidocaine and anti-inflammatory doxycycline to the sore site...
  7. Actions of Local Anesthetics on NMDA Receptors
    Meaghan Paganelli; Fiscal Year: 2013
    ..This project will evaluate the mechanism by which bupivacaine and lidocaine, two amide local anesthetics widely used in clinical practice inhibit NMDA receptor currents...
  8. Lidocaine Infusion as a Treatment for Cocaine Relapse and Craving
    BRYON H ADINOFF; Fiscal Year: 2013
    ..b>Lidocaine is an FDA approved medication that inhibits activation of NMDA receptors and suppresses production of NO and ERK...
  9. Role of dmCPu in acquisition and expression of nicotine CS evoked CR
    Sergios Charntikov; Fiscal Year: 2013
    ..Rats will be bilaterally infused with either lidocaine or saline before testing for the nicotine-evoked CR...
  10. Lidocaine for Neuroprotection During Cardiac Surgery
    Joseph P Mathew; Fiscal Year: 2013
    ..Recently we administered lidocaine as an infusion during and after cardiac surgery and found preliminary data for a protective effect of lidocaine ..
  11. MECHANISMS OF OPIATE AND STIMULANT DRUG REINFORCEMENT
    Aaron Ettenberg; Fiscal Year: 2010
    ..cocaine with centrally applied selective antagonists of neurotransmitter function, and to assess the impact of lidocaine-induced reversible lesions of selective brain structures on the runway behavior of cocaine-reinforced animals...
  12. MASS SPECTROMETER SYSTEM AND ACCESSORIES
    ALAN NIES; Fiscal Year: 1990
    ..This proposal is to investigate the pharmacokinetics of model compounds, lidocaine and antipyrine, in burn patients...
  13. The neurobiology of cue-induced relapse to ethanol-seeking behavior in mice
    Peter A Groblewski; Fiscal Year: 2010
    ..relapse by manipulating the neuronal activity of these regions using site-specific microinjections of lidocaine. By combining molecular, neuropharmacological, and behavioral techniques, these proposed experiments are ..
  14. Bioequivalence of topical drug products: in vitro - in vivo correlations
    Audra L Stinchcomb; Fiscal Year: 2013
    ..A systematic examination of several key classes of topical drug products will be undertaken including, but not limited to lidocaine, triamcinolone acetonide, tretinoin, acyclovir and metronidazole.
  15. CHANGES IN BRAIN AMINES BY DENTAL LOCAL ANESTHETICS
    ALFRED CIARLONE; Fiscal Year: 1980
    ..A total of fourteen experiments are planned and consist of: 1) Dose-response curves with lidocaine challenge and manipulation of brain serotonin; 2) Dose-response curves with lidocaine challenge and manipulation ..
  16. DEVELOPMENT OF A NOVEL BIOARTIFICIAL LIVER
    Jacek Rozga; Fiscal Year: 2002
    ..In addition, the HyBAL will be challenged with exogenous ammonium chloride, galactose and lidocaine. In vivo, he ability of HyBAL to support pigs with FHF will be examined...
  17. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..In the second Specific Aim we will study the analgesic mechanisms of FM subjects related to injections of lidocaine or saline placebo into painful trapezius muscle (TrapM) tender points (analgesia)...
  18. Amygdalar Modulation of Fear-Conditioned Changes in REM Sleep
    ADRIAN MORRISON; Fiscal Year: 2009
    ..training, we shall, in another group of rats, make temporary bilateral lesions of LA using a local anesthetic, lidocaine, immediately before training in the CFC protocol...
  19. DIRECT NEUROTOXICITY OF LOCAL ANESTHETICS
    Michael Johnson; Fiscal Year: 2002
    The objective of this proposal is to determine the mechanism of direct neurotoxicity of spinal (intrathecal) lidocaine. Other local anesthetics have a risk of persistent lumbosacral neurotoxicity of approximately 1 in 10,000...
  20. ELDER PAIN--ASSESSMENT OF INTENSITY
    Keela Herr; Fiscal Year: 1999
    ..from Phase 2 immediately preceding a clinic appointment for joint pain and 30 minutes after joint injection with lidocaine and steroid. Analysis will involve techniques similar to that in Phase 2...
  21. Airway sensory nerves and dyspnea in human subjects
    Nausherwan Burki; Fiscal Year: 2004
    ..effects of intravenous adenosine; 3) to examine whether directly blocking pulmonary C fibers with inhaled lidocaine abolishes the sensation of dyspnea induced by adenosine in these subjects/patients; 4) to investigate if ..
  22. Neural Mechanisms Underlying Individual Differences in 3,4-Methylenedioxymethamph
    Kevin Ball; Fiscal Year: 2010
    ..out the circuitry of relapse to MDMA- seeking behavior, we will combine this behavioral testing with temporary lidocaine inactivation of discrete sub-regions of medial prefrontal cortex, a brain region that appears to be a common ..
  23. Ontogeny of behavioral sensitization: associative and nonassociative processes
    SANDERS MCDOUGALL; Fiscal Year: 2012
    ..Second, lidocaine will be microinjected into various brain regions of adult and young rats to determine whether neural mechanisms ..
  24. Role of astroglia in cocaine-induced neurotoxicity
    Helene Benveniste; Fiscal Year: 2009
    ..increases in cortical [Ca++]i following intravenous administration of cocaine and the local anesthetic lidocaine but not with methylphenidate indicating that cocaine's local anesthetic properties but not its ..
  25. Supraspinal Modulation of Neuropathic Pain
    Bradley Taylor; Fiscal Year: 2007
    ..hypothesis that disruption of synaptic activity in the LC with the microinjection of either a local anesthetic (lidocaine) or a synaptic inhibitor (cobalt) will decrease the tactile and cold hypersensitivity that develops following ..
  26. BIOBEHAVIORAL PREDICTORS OF POSTOP PAIN & IMMUNE STATUS
    Joel Katz; Fiscal Year: 1999
    ..Patients undergoing abdominal hysterectomy will receive (1) pre-incisional epidural fentanyl and lidocaine followed by post-incisional epidural saline, (2) pre-incisional epidural saline followed by post-incisional ..
  27. Dental Anxiety, Pain & Melanocortin-1 Receptor Mutations
    Edwin Liem; Fiscal Year: 2005
    ..and thermal stimuli on unrestored lateral incisor teeth, will be measured after intra-oral injection of various lidocaine concentrations. The concentrations, which will be used in a randomized and double-blinded sequence, will be 0, 0...
  28. CARDIAC NA+ CHANNEL GATING AND LOCAL ANESTHETIC BLOCK
    STERLING WRIGHT; Fiscal Year: 2004
    ..will be a critical step toward explaining why clinically important local anesthetics, such as bupivacaine and lidocaine, affect cardiac physiology at circulating concentrations that have little effect on skeletal muscle physiology...
  29. INTERACTION OF ISCHEMIA, DRUGS, AND RATE ON CONDUCTION
    Wayne Cascio; Fiscal Year: 1991
    ..effect of simulated ischemia on rate-dependent conduction slowing induced by the Type 1 antiarrhythmic drugs (lidocaine, procainamide, flecainide) and Tetrodotoxin...
  30. MASS SPECTROMETRY ANALYSIS OF THE HUMAN CSF PROTEOME
    Dominic Desiderio; Fiscal Year: 2001
    ..A differential spinal diagnosis with lidocaine readily differentiates among the three different low back pain patient populations-controls (pain; non-pain ..
  31. FUNCTIONAL ORGANIZATION OF THE FRONTAL EYE FIELD
    Charles Bruce; Fiscal Year: 2003
    ..test any causal relation indicated by Aims 3 or 4 by deactivating the presumed effector site with muscimol or lidocaine and reanalyzing the functional properties of the neuron at the presumed target site...
  32. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 1999
    ..anesthetic market is dominated by one single preparation, called EMLA(R) (Astra) and consisting of a mixture of lidocaine base (2.5%) and prilocaine base (2.5%)...
  33. INTEGRATION OF INPUTS IN THE INFERIOR COLLICULUS
    Kevin Davis; Fiscal Year: 1999
    ..After isolating and characterizing units in the inferior colliculus, lidocaine will be applied to dorsal acoustic striae to reversibly block the input from the dorsal cochlear nucleus...
  34. DRUG EFFECTS ON ELECTRICALLY EXCITABLE MEMBRANES
    EDWARD GROOD; Fiscal Year: 1980
    ..drugs have been chosen for study: (a) drugs that suppress repetitive electrical activity (yohimbine, phenytoin, lidocaine and its derivatives) and (b) drugs that induce repetitive electrical activity (aconitine, germine, veratrine)...
  35. PHARMACOLOGIC MODIFICATION OF AFFERENT INPUT
    MURRAY MATTHEWS; Fiscal Year: 1980
    ....
  36. Spatial-temporal stimulus interactions in primate SI hand cortex neurons
    Jamie Reed; Fiscal Year: 2009
    ..In Aim 2, we will administer local lidocaine injections to block input from one hand and characterize responses to stimulation on the opposite hand, in order ..
  37. TZD Treatment of Cocaine Toxicity
    Guy Weinberg; Fiscal Year: 2005
    ..Clinically used local anesthetics, such as lidocaine, impair function of mitochondria, the intracellular organelles that synthesize adenosine triphosphate (ATP), the ..
  38. NEW DERMAL ANESTHETICS
    VINCENT CIOFALO; Fiscal Year: 2003
    ..market is dominated by a single preparation, called EMLA (AstraZeneca), which consists of a eutectic mixture of lidocaine and prilocaine bases...
  39. MOLECULAR PHARMACOLOGY OF CARDIAC ION CHANNELS
    Ronald Li; Fiscal Year: 2003
    ..We have discovered major differences in lidocaine sensitivity between cardiac and skeletal muscle sodium channels, defined interactions between local anesthetic ..
  40. Neuropharmacology of Pain in Spinal Cord Injury
    Christine Sang; Fiscal Year: 2005
    ..We propose to evaluate various doses of the sodium channel antagonist lidocaine, when given in combination with varying doses of the NMDA receptor antagonist dextromethorphan, in patients with ..
  41. Transdermal GnRH Delivery System to Treat Infertility
    Kenneth Swartz; Fiscal Year: 2006
    ..matrix electrolytes have been shown to be ideal for storage and delivery of molecules, such as lithium and lidocaine, that are delivered using iontophoresis, since the polymers trap the molecules and only release them when the ..
  42. Novel Topical Treatment for Postherpetic Neuralgia
    Charles Gauntt; Fiscal Year: 2005
    ..Topical treatments such as capsaicin cream, acetylsalicylic acid (aspirin), anesthetic creams, and lidocaine patches either require multiple daily applications or are limited in their use due to the potential for elevated ..
  43. NPY and Nerve Injury-Induced Tactile Hypersensitivity
    Frank Porreca; Fiscal Year: 2007
    ..e., for at least more than 200 days). Lesions of the dorsal columns (DC) or microinjection of lidocaine into the n...
  44. RVM CCK and Neuropathic Pain
    Josephine Lai; Fiscal Year: 2007
    ..descending facilitation arising from the rostral ventromedial medulla (RVM) is suggested by the finding that lidocaine injected into the RVM effectively blocks experimental neuropathic pain at post-inj ury day 6 (and later), but ..
  45. MEDICARE CAPITATION AND QUALITY OF CARE FOR ACUTE MI
    Stephen Soumerai; Fiscal Year: 1999
    ..to: 1) adherence to national guidelines for effective drugs for AMI; 2) non-adherence to national guidelines for lidocaine use (when contraindicated); 3) triage delay (time from symptom onset to hospital presentation); 4) and, among ..
  46. Access Paths for Sodium-Channel Blocking Antiarrhythmics
    Peter Lee; Fiscal Year: 2005
    ..include; 1) the effects of membrane depolarization, often seen in ischemia, on the drug-channel interaction of lidocaine and related compounds, 2) identification of other drug-paths to better characterize the drug-channel ..
  47. MOLECULAR INTERACTIONS BETWEEN LIDOCAINE AND NA CHANNELS
    NICHOLAS KAMBOURIS; Fiscal Year: 1999
    ..These goals will serve as a platform upon which to develop a career as an independent investigator in ion-channel electrophysiology and pharmacology. ..
  48. NEURAL MECHANISMS OF SOCIAL RECOGNITION AND MEMORY
    Robert Johnston; Fiscal Year: 2009
    ..2) Using micro-infusion of lidocaine, we will determine which brain regions are necessary for individual and sex recognition and appropriate ..
  49. CNS Stress Pathways and the Development of Acute HAAF
    Dianne Lattemann; Fiscal Year: 2003
    ..We will reversibly inactivate the THPVP and the DMH with lidocaine or the inhibitory GABA analog muscimol and measure neuroendocnne responses to hypoglycemia, with hypothesized ..
  50. MECHANISMS OF DEEP BRAIN STIMULATION.
    Jonathan Dostrovsky; Fiscal Year: 2003
    ..Additionally, effects of high frequency and of lidocaine and muscimol microinjections into STN will be assessed on tremor, rigidity and bradykinesia...
  51. FUNCTIONAL STREAMS IN THE PRIMATE VISUAL CORTEX
    Ehud Kaplan; Fiscal Year: 2000
    ..populations such as the M-stream and b) silence selected neuronal populations by pressure injections of Mg++ or lidocaine into portions of the lateral geniculate nucleus, 2) compare optical signals recorded from CO blobs with those ..
  52. COCAINE: EFFECTS AND MODIFICATION OF EUPHORIA IN MAN
    ROBERT BYCK; Fiscal Year: 1980
    ..Using cocaine, lidocaine, amphetamine, and placebo, we are comparing the differences in physiological and psychological effects attained ..
  53. FOREBRAIN OPIOID RECEPTORS AND HYPOALGESIA
    FRED HELMSTETTER; Fiscal Year: 1993
    ..receptors within the amygdala and [4] assess the involvement of descending antinociceptive systems by using lidocaine to block neural activity at critical brainstem sites (periaqueductal gray, nucleus raphe magnus) following ..
  54. CELL ASSEMBLIES, PATTERN COMPLETION AND THE AGING BRAIN
    Carol Barnes; Fiscal Year: 2003
    ..record groups of cells in the right hippocampus before and after the rats' left hippocampus is injected with lidocaine via indwelling cannula...
  55. RVM CCK, Pain, and Opioid Tolerance
    Todd Vanderah; Fiscal Year: 2006
    ..block morphine-induced pain and antinociceptive tolerance are rostral ventromedial medulla (RVM) injection of lidocaine and bilateral lesions of the dorsolateral funiculus (DLF) suggesting a tonically active descending pain ..
  56. Non-invasive self administration methodology for mice
    Jay Hirsh; Fiscal Year: 2004
    ..the self-administration paradigm: these controls include use of related but nonaddicting substances such as lidocaine and measurement of additional physiological correlates of cocaine exposure...
  57. MECHANISMS OF RAPID RECEPTIVE FIELD REORGANIZATION
    HARRIS SCHWARK; Fiscal Year: 2001
    ..In the somatosensory system, subcutaneous injection of lidocaine into a neuron's receptive field results in marked reorganization of the receptive field, such that within ..
  58. FUNCTIONAL IMAGING OF TINNITUS AND HEARING LOSS
    Alan Lockwood; Fiscal Year: 2002
    ..who can modulate the loudness or pitch of their tinnitus with an oral-facial movement or eye movements? 4) Do lidocaine and residual inhibition reduce activity in regions of the brain activated by tinnitus? 5) What is the anatomical ..
  59. DRUG INTERACTIONS WITH MODIFIED CARDIAC ION CHANNELS
    Jonathan Makielski; Fiscal Year: 1999
    ..for the components of LA block using prototype charged (QX-222), uncharged (benzocaine), and mixed charge (lidocaine) LA (Aim 1)...
  60. Regulation of Stress-Induced Cortical Monoamine Activity
    Gina Forster; Fiscal Year: 2004
    ..release recorded from the mPFC before and after transient blockade of pathways with the sodium channel blocker lidocaine. Subsequent experiments using a similar methodology will determine the involvement of the neurohormone ..
  61. GLUTAMATE AND COCAINE CONDITIONED LOCOMOTION
    Gregory Hotsenpiller; Fiscal Year: 2003
    ..regions historically found to be relevant for conditioned drug responses will be examined through lesions and lidocaine inactivation...
  62. NEUROBIOLOGY OF MULTIPLE MEMORY SYSTEMS
    Mark Packard; Fiscal Year: 2001
    ..nervous system manipulations in rats, including neural inactivation (via injection of the local anesthetic lidocaine), and post-training intracerebral injections of glutamatergic agonist and antagonist drugs that are selective ..
  63. NEURAL ANALYSIS OF HABITUATION TO PSYCHOLOGICAL STRESS
    Serge Campeau; Fiscal Year: 2000
    ..This area will be inactivated temporarily with intranuclear injections of lidocaine during habituation training, but will be active on the test day...
  64. CYP3A Function in Aging AfricanAmericans
    David Greenblatt; Fiscal Year: 2006
    ..The study paradigm will assess: a. Hepatic blood flow (HBF), based on clearance of low-dose intravenous lidocaine; b Pharmacokinetics and pharrnacodynamics of intravenous and oral midazolam, a "pure" CYP3A substrate; c The ..
  65. Accelerated Discovery and Development of New Pain Therapeutics
    Lillian Chiang; Fiscal Year: 2007
    ..Currently available drugs include opioids, anti-epileptics, topicals such as lidocaine, NMDA antagonists, and tricyclic antidepressants, none of which achieve clinical significance greater than 50%...