acetaminophen

Summary

Summary: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

Top Publications

  1. ncbi Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
    T C Dinis
    Laboratorio de Bioquimica, Faculdade de Farmacia, Universidade de Coimbra, Portugal
    Arch Biochem Biophys 315:161-9. 1994
  2. ncbi Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    Drug Metab Rev 44:88-106. 2012
  3. ncbi Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    George Ostapowicz
    Department of Medicine, Gold Coast Hospital, 108 Nerang Street, Southport, QLD 4215, Australia
    Ann Intern Med 137:947-54. 2002
  4. pmc Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
    Daniel J Antoine
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    J Hepatol 56:1070-9. 2012
  5. ncbi High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    A Enomoto
    Toxicology Division II, Laboratory of Pathology, Institute of Environmental Toxicology, 4321 Uchimoriya, Mitsukaido, Ibaraki 303 0043, Japan
    Toxicol Sci 59:169-77. 2001
  6. ncbi TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol
    David A Andersson
    King s College London, Wolfson Centre for Age Related Diseases, London SE1 1UL, UK
    Nat Commun 2:551. 2011
  7. pmc Activation of autophagy protects against acetaminophen-induced hepatotoxicity
    Hong Min Ni
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 55:222-32. 2012
  8. pmc PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury
    Trista E North
    Department of Pathology, Beth Israel Deaconess Medical Center, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17315-20. 2010
  9. ncbi Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study
    Anne M Larson
    Department of Internal Medicine, Division of Gastroenterology, University of Washington Medical Center, Seattle, 98195, USA
    Hepatology 42:1364-72. 2005
  10. ncbi Acetaminophen-induced hepatotoxicity
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Drug Metab Dispos 31:1499-506. 2003

Detail Information

Publications352 found, 100 shown here

  1. ncbi Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers
    T C Dinis
    Laboratorio de Bioquimica, Faculdade de Farmacia, Universidade de Coimbra, Portugal
    Arch Biochem Biophys 315:161-9. 1994
    The action of the phenolic compounds acetaminophen, salicylate, and 5-aminosalicylate (5-ASA) as inhibitors of lipid peroxidation was studied under conditions suitable for establishing their antioxidant potencies...
  2. ncbi Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, 66160, USA
    Drug Metab Rev 44:88-106. 2012
    ..For example, acetaminophen overdose is currently the most frequent cause of acute liver failure in the United States and Great Britain...
  3. ncbi Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States
    George Ostapowicz
    Department of Medicine, Gold Coast Hospital, 108 Nerang Street, Southport, QLD 4215, Australia
    Ann Intern Med 137:947-54. 2002
    ..Because acute liver failure is rare, related data have been sparse. Studies have suggested that viral hepatitis is the most common underlying cause of this condition...
  4. pmc Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
    Daniel J Antoine
    Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK
    J Hepatol 56:1070-9. 2012
    ..keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo...
  5. ncbi High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    A Enomoto
    Toxicology Division II, Laboratory of Pathology, Institute of Environmental Toxicology, 4321 Uchimoriya, Mitsukaido, Ibaraki 303 0043, Japan
    Toxicol Sci 59:169-77. 2001
    ..examine the role of Nrf2 in protection against xenobiotic toxicity, the sensitivity of nrf2 knockout mice to acetaminophen (N-acetyl-4-aminophenol (APAP)) was analyzed...
  6. ncbi TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol
    David A Andersson
    King s College London, Wolfson Centre for Age Related Diseases, London SE1 1UL, UK
    Nat Commun 2:551. 2011
    ..Here we show that the antinociceptive effects of spinal and systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice...
  7. pmc Activation of autophagy protects against acetaminophen-induced hepatotoxicity
    Hong Min Ni
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Hepatology 55:222-32. 2012
    ..b>Acetaminophen (APAP) overdose can cause liver injury in animals and humans by inducing mitochondria damage and subsequent ..
  8. pmc PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury
    Trista E North
    Department of Pathology, Beth Israel Deaconess Medical Center, MA 02115, USA
    Proc Natl Acad Sci U S A 107:17315-20. 2010
    b>Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States...
  9. ncbi Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study
    Anne M Larson
    Department of Internal Medicine, Division of Gastroenterology, University of Washington Medical Center, Seattle, 98195, USA
    Hepatology 42:1364-72. 2005
    Severe acetaminophen hepatotoxicity frequently leads to acute liver failure (ALF). We determined the incidence, risk factors, and outcomes of acetaminophen-induced ALF at 22 tertiary care centers in the United States...
  10. ncbi Acetaminophen-induced hepatotoxicity
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Drug Metab Dispos 31:1499-506. 2003
    The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases of toxicity were described in Dr. Gillette's laboratory in the 1970s...
  11. pmc Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice
    Scott A Reisman
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 109:31-40. 2009
    b>Acetaminophen (AA) is a widely used antipyretic drug that causes hepatotoxicity at high doses...
  12. pmc Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure
    William M Lee
    Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8887, USA
    Gastroenterology 137:856-64, 864.e1. 2009
    N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetaminophen-related acute liver failure.
  13. ncbi Acetaminophen increases blood pressure in patients with coronary artery disease
    Isabella Sudano
    Cardiovascular Center Cardiology University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Circulation 122:1789-96. 2010
    ..drugs are associated with increased risk for acute cardiovascular events, current guidelines recommend acetaminophen as the first-line analgesic of choice on the assumption of its greater cardiovascular safety...
  14. ncbi c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity
    Basuki K Gunawan
    Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Gastroenterology 131:165-78. 2006
    In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases.
  15. ncbi High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo
    Daniel J Antoine
    MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool L693GE, UK
    Toxicol Sci 112:521-31. 2009
    ..immune activation have been defined as features of the toxicological response associated with the hepatotoxin acetaminophen (APAP)...
  16. pmc Acute liver failure: Summary of a workshop
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas Southwestern Medical School, Dallas, TX 75390 8887, USA
    Hepatology 47:1401-15. 2008
    ..The outcome of ALF varies by etiology, favorable prognoses being found with acetaminophen overdose, hepatitis A, and ischemia (approximately 60% spontaneous survival), and poor prognoses with drug-..
  17. pmc The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
    Mitchell R McGill
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Clin Invest 122:1574-83. 2012
    b>Acetaminophen (APAP) overdose is the predominant cause of acute liver failure in the United States. Toxicity begins with a reactive metabolite that binds to proteins...
  18. ncbi Apoptosis and necrosis in the liver: a tale of two deaths?
    Harmeet Malhi
    Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA
    Hepatology 43:S31-44. 2006
    ....
  19. ncbi Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress
    T R Knight
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W. Markham St, Little Rock, AR 72205-7199, USA
    Toxicol Sci 62:212-20. 2001
    Peroxynitrite may be involved in acetaminophen-induced liver damage. However, it is unclear if peroxynitrite is generated in hepatocytes or in the vasculature...
  20. ncbi Intracellular signaling mechanisms of acetaminophen-induced liver cell death
    Hartmut Jaeschke
    Liver Research Institute, University of Arizona, College of Medicine, Tucson, Arizona 85737, USA
    Toxicol Sci 89:31-41. 2006
    b>Acetaminophen hepatotoxicity is the leading cause of drug-induced liver failure. Despite substantial efforts in the past, the mechanisms of acetaminophen-induced liver cell injury are still incompletely understood...
  21. pmc Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Liver Int 32:8-20. 2012
    b>Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of acute liver failure in the western world...
  22. ncbi Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme
    Richard Beasley
    Medical Research Institute of New Zealand, Wellington, New Zealand
    Lancet 372:1039-48. 2008
    ..We studied 6-7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma...
  23. ncbi Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials
    Roman Prymula
    Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
    Lancet 374:1339-50. 2009
    ..We assessed the effect of prophylactic administration of paracetamol at vaccination on infant febrile reaction rates and vaccine responses...
  24. ncbi Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three
    Richard W Beasley
    Medical Research Institute of New Zealand, Private Bag 7902, Wellington 6242, New Zealand
    Am J Respir Crit Care Med 183:171-8. 2011
    There is epidemiological evidence that the use of acetaminophen may increase the risk of developing asthma.
  25. pmc The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study
    Alemayehu Amberbir
    School of Public Health, Addis Ababa University, PO Box 80596, Addis Ababa, Ethiopia
    Am J Respir Crit Care Med 183:165-70. 2011
    b>Acetaminophen has been hypothesized to increase the risk of asthma and allergic disease, and geohelminth infection to reduce the risk, but evidence from longitudinal cohort studies is lacking.
  26. pmc An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen
    K Chan
    Cardiovascular Research Institute, Department of Laboratory Medicine and Howard Hughes Medical Institute, University of California, San Francisco, CA 94143-0793, USA
    Proc Natl Acad Sci U S A 98:4611-6. 2001
    ..We investigated its role in the detoxification of acetaminophen [N-acetyl-p-aminophenol (APAP)]-induced hepatotoxicity...
  27. ncbi Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice
    Cynthia Ju
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Chem Res Toxicol 15:1504-13. 2002
    Hepatic injury induced by various toxic agents, including acetaminophen (APAP), has been attributed, in part, to the production of proinflammatory cytokines and other mediators by resident Kupffer cells within the liver...
  28. pmc Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury
    Michael P Holt
    Department of Pharmaceutical Sciences, University of Colorado Denver, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Leukoc Biol 84:1410-21. 2008
    The role of macrophages in the pathogenesis of acetaminophen (APAP)-induced liver injury remains controversial, as it has been demonstrated that these cells display pro-toxicant and hepato-protective functions...
  29. ncbi The pharmacokinetics of intravenous paracetamol in neonates: size matters most
    Karel Allegaert
    Neonatal Intensive Care Unit, University Hospital, Herestraat 49, Leuven, Belgium
    Arch Dis Child 96:575-80. 2011
    ..The aim was to describe intravenous paracetamol pharmacokinetics, determine major covariates and suggest a dosing regimen for (pre)term neonates...
  30. pmc Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
    Andrew D Patterson
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA
    Hepatology 56:281-90. 2012
    b>Acetaminophen (APAP) overdose causes acute liver failure in humans and rodents due in part to the destruction of mitochondria as a result of increased oxidative stress followed by hepatocellular necrosis...
  31. ncbi Neutrophil depletion protects against murine acetaminophen hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Disease, Department of Medicine, The Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 43:1220-30. 2006
    We previously reported that liver natural killer (NK) and NKT cells play a critical role in mouse model of acetaminophen (APAP)-induced liver injury by producing interferon gamma (IFN-gamma) and modulating chemokine production and ..
  32. ncbi Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes
    Archana Kumari
    Herbal Research Section, CSIR Indian Institute of Toxicology Research, MG Marg, 226001 Lucknow, India
    Food Chem Toxicol 50:1781-9. 2012
    ..This study was carried out to explore cytoprotective potential of lupeol, a triterpene, against acetaminophen (AAP)-induced toxicity in rat hepatocytes. AAP exposure significantly (p<0...
  33. pmc Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury
    Hong Min Ni
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 127:438-50. 2012
    ..We have previously demonstrated that pharmacological induction of autophagy by rapamycin protects against acetaminophen (APAP)-induced liver injury in mice...
  34. ncbi Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine
    Ehsan Kheradpezhouh
    Department of Pharmacology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
    Eur J Pharmacol 628:274-81. 2010
    b>Acetaminophen is one of the most popular analgesic and antipyretic drugs and its overdose, which can cause severe damage to liver and kidneys, is one of the most common reasons of emergency admissions...
  35. pmc HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity
    Mitchell R McGill
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Hepatology 53:974-82. 2011
    b>Acetaminophen (APAP) overdose is the leading cause of acute liver failure in Western countries. In the last four decades much progress has been made in our understanding of APAP-induced liver injury through rodent studies...
  36. ncbi Curcumin prevents oxidative renal damage induced by acetaminophen in rats
    M Cekmen
    Department of Biochemistry, Kocaeli University, Istanbul, Turkey
    Food Chem Toxicol 47:1480-4. 2009
    b>Acetaminophen (APAP) can cause life-threatening renal damages and there is no specific treatment for APAP-induced renal damage...
  37. ncbi Acetaminophen toxicity: changing perceptions on a social/medical issue
    William M Lee
    University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hepatology 46:966-70. 2007
  38. ncbi Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial
    Paul M Peloso
    Division of Rheumatology, Roy and Lucille Carver College of Medicine, University of Iowa Health Care E330 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Rheumatol 31:2454-63. 2004
    To evaluate the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP).
  39. pmc Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2
    C M Hogaboam
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Am J Pathol 156:1245-52. 2000
    ..Accordingly, the present study addressed the role of CCR2 in mice acutely challenged with acetaminophen (APAP)...
  40. ncbi Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin
    Hawjyh Chiu
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Toxicol Appl Pharmacol 181:106-15. 2002
    ..In the present studies, we analyzed expression of this enzyme in macrophages and hepatocytes following acetaminophen administration and its potential role in hepatotoxicity...
  41. pmc Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
    Avlin B Imaeda
    Section of Digestive Diseases, Yale University, New Haven, Connecticut 06520 8019, USA
    J Clin Invest 119:305-14. 2009
    ..One important example of this type of injury is acetaminophen-induced liver injury, in which the initial toxic injury is followed by innate immune activation...
  42. ncbi Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure
    William M Lee
    Division of Digestive and Liver Diseases, University of Texas, Southwestern Medical Center, Dallas, 75390 9151, USA
    Hepatology 40:6-9. 2004
    b>Acetaminophen overdose is the leading cause for calls to Poison Control Centers (>100,000/year) and accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 458 deaths due to acute liver failure ..
  43. pmc Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage
    A Badmann
    Division of Immunopathology, Institute of Pathology, University of Bern, and Visceral and Transplantation Surgery, University Hospital, Bern, Switzerland
    Cell Death Dis 2:e171. 2011
    b>Acetaminophen (N-acetyl-para-aminophenol (APAP), paracetamol) is a commonly used analgesic and antipyretic agent...
  44. ncbi Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1
    Frank J Gonzalez
    Laboratory of Metabolism, National Cancer Institute, Bethesda, MD 20892, USA
    Mutat Res 569:101-10. 2005
    ..illustrate the role of P450s in toxicity, CYP2E1-null mice were employed with the commonly used analgesic drug acetaminophen. CYP2E1 is the rate-limiting enzyme that initiates the cascade of events leading to acetaminophen ..
  45. pmc Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008
  46. ncbi Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity
    Zhang Xu Liu
    Research Center for Liver Disease, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Gastroenterology 127:1760-74. 2004
    ..released by nonparenchymal inflammatory cells in the liver have been implicated in the progression of acetaminophen (APAP) hepatotoxicity...
  47. ncbi Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood
    S O Shaheen
    Department of Public Health Sciences, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Clin Exp Allergy 35:18-25. 2005
    We recently found that paracetamol (acetaminophen) use in late pregnancy was associated with an increased risk of early wheezing in the offspring.
  48. ncbi The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 8:434-40. 2009
    ..The Paracetamol (Acetaminophen) In Stroke (PAIS) trial aimed to assess whether early treatment with paracetamol improves functional outcome ..
  49. ncbi Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 22:383-90. 2008
    For more than three decades, acetaminophen (INN, paracetamol) has been claimed to be devoid of significant inhibition of peripheral prostanoids...
  50. pmc Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort
    Matthew S Perzanowski
    Columbia Center for Children s Environmental Health CCCEH, New York, NY 10032, USA
    Thorax 65:118-23. 2010
    b>Acetaminophen has been associated with asthma and is in part metabolised via the glutathione pathway...
  51. ncbi Disparate geographic prevalences of asthma, allergic rhinoconjunctivitis and atopic eczema among adolescents in five Canadian cities
    Hong Yu Wang
    Firestone Institute for Respiratory Health, St Joseph s Healthcare, Hamilton, ON, Canada
    Pediatr Allergy Immunol 21:867-77. 2010
    ..Multivariable logistic regression analyses showed the region of residence, being born in Canada, recent use of acetaminophen and heavy exposure to traffic exhaust were significantly associated with all three allergic conditions, while ..
  52. ncbi Endocannabinoid and serotonergic systems are needed for acetaminophen-induced analgesia
    Christophe Mallet
    INSERM E9904, U766, Facultes de Medecine et de Pharmacie, 28, Place Henri Dunant, B P 38, F 63001 Clermont Ferrand Cedex 01, France
    Pain 139:190-200. 2008
    b>Acetaminophen is the most used analgesic/antipyretic drug. Its unclear mechanism of action could rely on cyclooxygenase inhibition, NO synthesis blockade or reinforcement of the serotonergic system...
  53. ncbi Acetaminophen reduces social pain: behavioral and neural evidence
    C Nathan DeWall
    Department of Psychology, University of Kentucky, Lexington, KY 40506 0044, USA
    Psychol Sci 21:931-7. 2010
    ..To the extent that these pain processes overlap, acetaminophen, a physical pain suppressant that acts through central (rather than peripheral) neural mechanisms, may also ..
  54. ncbi Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos
    Stefan Weigt
    Institute of Toxicology, Merck Serono, 64293 Darmstadt, Germany
    Toxicology 275:36-49. 2010
    ..b>Acetaminophen (APAP) is considered not to be teratogenic in vivo, however, in vitro teratogenic effects were observed, e.g...
  55. pmc Curcumin protects against acetaminophen-induced apoptosis in hepatic injury
    Gang Li
    Gang Li, Jun Bao Chen, Chao Wang, Zhi Xu, Hao Nie, Xiao Yan Qin, Xiao Mei Chen, Quan Gong, Department of Immunology, School of Medicine, Yangtze University, Jingzhou 434023, Hubei Province, China
    World J Gastroenterol 19:7440-6. 2013
    To explore the effects of curcumin (CMN) on hepatic injury induced by acetaminophen (APAP) in vivo.
  56. ncbi Lupeol prevents acetaminophen-induced in vivo hepatotoxicity by altering the Bax/Bcl-2 and oxidative stress-mediated mitochondrial signaling cascade
    Archana Kumari
    Herbal Research Section, CSIR Indian Institute of Toxicology Research, M G Marg 226001, Lucknow 226001, India
    Life Sci 90:561-70. 2012
    ..The present study was conducted to explore the hepatoprotective potential of lupeol against acetaminophen (AAP)-induced hepatotoxicity in Wistar rats.
  57. ncbi Source and characterization of hepatic macrophages in acetaminophen-induced acute liver failure in humans
    Charalambos Gustav Antoniades
    Institute of Liver Studies and Cellular Biology of Inflammation, King s College London, London, United Kingdom
    Hepatology 56:735-46. 2012
    b>Acetaminophen-induced acute liver failure (AALF) is associated with innate immunity activation, which contributes to the severity of hepatic injury and clinical outcome...
  58. ncbi The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity
    Connie Cheung
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Drug Metab Dispos 33:449-57. 2005
    ..and activates a wide array of toxicological substrates, including alcohols, the widely used analgesic acetaminophen, acetone, benzene, halothane, and carcinogens such as azoxymethane and dimethylhydrazine...
  59. pmc Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice
    Georgianna G Gould
    Department of Physiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Prog Neuropsychopharmacol Biol Psychiatry 38:260-9. 2012
    Supratherapeutic doses of the analgesic acetaminophen (paracetomol) are reported to promote social behavior in Swiss mice...
  60. ncbi Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Pharm 389:24-31. 2010
    ....
  61. pmc Role of galectin-3 in classical and alternative macrophage activation in the liver following acetaminophen intoxication
    Ana Cristina Docan Dragomir
    Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    J Immunol 189:5934-41. 2012
    Inflammatory macrophages have been implicated in hepatotoxicity induced by the analgesic acetaminophen (APAP)...
  62. ncbi Efficacy of adipose tissue-mesenchymal stem cell transplantation in rats with acetaminophen liver injury
    Federico Salomone
    U O C di Gastroenterologia, Ospedale di Acireale, Azienda Sanitaria Provinciale di Catania, Catania, Italy Electronic address
    Stem Cell Res 11:1037-44. 2013
    b>Acetaminophen intoxication is a leading cause of acute liver failure. Liver transplantation for acute liver failure is limited by the availability of donor organs...
  63. pmc Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes
    Angela S Burke
    Department of Pharmacology and Toxicology College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Chem Res Toxicol 23:1286-92. 2010
    b>Acetaminophen (APAP) toxicity in primary mouse hepatocytes occurs in two phases...
  64. pmc Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 104:261-73. 2008
    Treatment with hepatotoxicants such as acetaminophen (APAP) causes resistance to a second, higher dose of the same toxicant (autoprotection)...
  65. ncbi Disposition of acetaminophen at 4, 6, and 8 g/day for 3 days in healthy young adults
    C K Gelotte
    McNeil Consumer Healthcare, Fort Washington, Pennsylvania, USA
    Clin Pharmacol Ther 81:840-8. 2007
    The objective of this study was to determine the disposition and tolerability of 1, 1.5, and 2 g acetaminophen every 6 h for 3 days...
  66. pmc Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury
    Mohammed Bourdi
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 1760, United States
    Chem Res Toxicol 24:794-6. 2011
    ..We show here that these mispairings do occur frequently and can lead to inaccurate and conflicting findings...
  67. pmc Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity
    Mary Lynn Bajt
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 122:598-605. 2011
    b>Acetaminophen (APAP) overdose causes liver injury in humans and mice...
  68. ncbi Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use
    Maaike Schutte
    Department of Molecular and Cell Biology, LGC, Queens Road, Teddington, United Kingdom
    Assay Drug Dev Technol 9:475-86. 2011
    ..In toxicity studies the hepatocytes in the 3D scaffolds also show increased sensitivity to the model toxicant acetaminophen. These improvements over monolayer culture and the availability of this new easy to use 3D scaffold system ..
  69. ncbi Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever
    Elizabeth R Southey
    Watermeadow Medical, Witney, Oxfordshire, UK
    Curr Med Res Opin 25:2207-22. 2009
    ..The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age...
  70. ncbi Paracetamol and antibiotics in childhood and subsequent development of wheezing/asthma: association or causation?
    Franca Rusconi
    Unit of Epidemiology, Anna Meyer Children s University Hospital, Florence, Italy
    Int J Epidemiol 40:662-7. 2011
    ....
  71. ncbi Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Med Res Opin 23:147-61. 2007
    To examine the efficacy and safety of tramadol/acetaminophen (APAP) for the management of painful diabetic peripheral neuropathy (DPN).
  72. ncbi A clinical trial of the effectiveness of regularly scheduled versus as-needed administration of acetaminophen in the management of discomfort in older adults with dementia
    Martha D Buffum
    Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Am Geriatr Soc 52:1093-7. 2004
    ..nursing home patients with dementia and a painful condition whether the regularly scheduled administration of acetaminophen (650 mg four times a day (qid)) was more or less effective than as-needed (prn) administration of ..
  73. pmc Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity
    Darren G N Craig
    Scottish Liver Transplantation Unit, Royal Infirmary of Edinburgh, Little France, Edinburgh, UK
    Br J Clin Pharmacol 73:285-94. 2012
    Paracetamol (acetaminophen) poisoning remains the major cause of severe acute hepatotoxicity in the UK...
  74. ncbi Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial
    Paul B Watkins
    Department of Medicine, University of North Carolina, Chapel Hill, USA
    JAMA 296:87-93. 2006
    During a clinical trial of a novel hydrocodone/acetaminophen combination, a high incidence of serum alanine aminotransferase (ALT) elevations was observed.
  75. pmc Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial
    Alastair D Hay
    Academic Unit of Primary Health Care, NIHR National School for Primary Care Research, Department of Community Based Medicine, University of Bristol, Bristol BS8 2AA
    BMJ 337:a1302. 2008
    To investigate whether paracetamol (acetaminophen) plus ibuprofen are superior to either drug alone for increasing time without fever and the relief of fever associated discomfort in febrile children managed at home.
  76. ncbi The association of acetaminophen and asthma prevalence and severity
    John T McBride
    Department of Pediatrics, Akron Children s Hospital, Akron, OH 44308, USA
    Pediatrics 128:1181-5. 2011
    The epidemiologic association between acetaminophen use and asthma prevalence and severity in children and adults is well established...
  77. pmc Paracetamol use in early life and asthma: prospective birth cohort study
    Adrian J Lowe
    Murdoch Childrens Research Institute, Royal Children s Hospital, Parkville, VIC 3052, Australia
    BMJ 341:c4616. 2010
    ..To determine if use of paracetamol in early life is an independent risk factor for childhood asthma...
  78. pmc Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials
    W Zhang
    Academic Rheumatology, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham NG5 1PB, UK
    Ann Rheum Dis 63:901-7. 2004
    To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA).
  79. pmc Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life
    Victoria Persky
    Division of Epidemiology and Biostatistics, The University of Illinois, Chicago School of Public Health, Chicago, Illinois 60612, USA
    Ann Allergy Asthma Immunol 101:271-8. 2008
    Prevalence of asthma in developed countries increased between the 1970s and the 1990s. One factor that might contribute to the trends in asthma is the increased use of acetaminophen vs aspirin in children and pregnant women.
  80. pmc Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a prospective case series
    Mònica Sabaté
    Fundacio Institut Catala de Farmacologia, Universitat Autonoma de Barcelona, Hospital Universitari Vall d Hebron, Barcelona, Spain
    BMC Gastroenterol 11:80. 2011
    ..The aim is to describe the characteristics of patients admitted to hospital with jaundice who had previous exposure to therapeutic doses of paracetamol. An assessment of the causality role of paracetamol was performed in each case...
  81. ncbi Acetaminophen hepatotoxicity and acute liver failure
    Linda J Chun
    Albert Einstein College of Medicine, USA
    J Clin Gastroenterol 43:342-9. 2009
    b>Acetaminophen-induced hepatotoxicity is a common consequence of acetaminophen overdose and may lead to acute liver failure (ALF)...
  82. pmc Prenatal exposure to acetaminophen and asthma in children
    Elizabeth M Kang
    Center for Perinatal Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, Connecticut 06510, USA
    Obstet Gynecol 114:1295-306. 2009
    To estimate whether prenatal exposure to acetaminophen is associated with risk of diagnosed asthma and asthma symptoms in children.
  83. ncbi Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea
    YoungHee Kim
    School of Public Health, Seoul National University, Seoul, Republic of Korea
    Environ Int 33:370-5. 2007
    ..In this study, the four most abundantly used pharmaceuticals in Korea, namely acetaminophen, carbamazepine, cimetidine, and diltiazem, and six sulfonamide related antibiotics, including sulfamethoxazole,..
  84. ncbi Acetaminophen induces ER dependent signaling in mouse liver
    Gabor Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest POB 260, Hungary
    Arch Biochem Biophys 459:273-9. 2007
    Role of endoplasmic reticulum (ER) in liver injury by acetaminophen (AAP) was studied in vivo in mice...
  85. pmc Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products
    Hartmut Jaeschke
    Department of Pharmacology, Toxicology and Therapeutics University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Life Sci 88:737-45. 2011
    ..b>Acetaminophen-induced liver injury, especially in mice, is an attractive and widely used model for this purpose because it ..
  86. ncbi Aspirin, acetaminophen, and ibuprofen: their effects on orthodontic tooth movement
    Oscar R Arias
    Department of Orthodontics, Universidad Intercontinental, Mexico DF, Mexico
    Am J Orthod Dentofacial Orthop 130:364-70. 2006
    ..of this study were to determine by direct measurement the effects that acetylsalicylic acid, ibuprofen, and acetaminophen have on orthodontic tooth movement in rats and to evaluate histologically the differences in bone resorption ..
  87. ncbi Predicted and measured concentrations for selected pharmaceuticals in UK rivers: implications for risk assessment
    Jonathan P Bound
    Centre for Environmental Policy, Imperial College London, London SW7 2BP, UK
    Water Res 40:2885-92. 2006
    ..Results from one site demonstrated a considerable increase in concentrations of ibuprofen, salbutamol and paracetamol downstream from the treatment works; however, no link was established for a second works...
  88. pmc Acetaminophen pharmacokinetics in children with nonalcoholic fatty liver disease
    Nicole J Barshop
    Department of Pediatrics, University of California, San Diego, USA
    J Pediatr Gastroenterol Nutr 52:198-202. 2011
    The aim of the study was to evaluate UDP-glucuronyltransferase activity and the pharmacokinetics of a single oral dose of acetaminophen (APAP) in children with nonalcoholic fatty liver disease (NAFLD).
  89. pmc SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
    Zhongping Lu
    Center for Molecular Medicine, NHLBI, National Institutes of Health, Building 10 CRC, Room 5 3150, 10 Center Drive, Bethesda, Maryland 20892, USA
    EMBO Rep 12:840-6. 2011
    b>Acetaminophen/paracetamol-induced liver failure--which is induced by the binding of reactive metabolites to mitochondrial proteins and their disruption--is exacerbated by fasting...
  90. ncbi Stroke severity determines body temperature in acute stroke
    G Boysen
    Department of Neurology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Stroke 32:413-7. 2001
    ..Experimental studies showing that hyperthermia increases infarct size have lent credibility to this assumption. The aim of the present study was to test the hypothesis that initial body temperature is of importance for stroke outcome...
  91. ncbi FDA proposals to limit the hepatotoxicity of paracetamol (acetaminophen): are they reasonable?
    Garry G Graham
    Department of Clinical Pharmacology, St Vincent s Hospital, Darlinghurst, NSW, 2010, Australia
    Inflammopharmacology 18:47-55. 2010
    ..Adoption of these two recommendations may lead to the increased use of NSAIDs with the potential of increasing incidence of NSAIDs-related adverse reactions...
  92. ncbi The efficacy comparison of ibuprofen, acetaminophen-codeine, and placebo premedication therapy on the depth of anesthesia during treatment of inflamed teeth
    Jalil Modaresi
    Department of Endodontics, Dental School, Shahid Sadoughi University of Medical Sciences, Yazd and Isfahan, Iran
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:399-403. 2006
    The purpose of this study was to elucidate whether premedication therapy with acetaminophen-codeine or ibuprofen is able to increase the depth of anesthesia in inflamed teeth...
  93. ncbi Circulating apoptotic and necrotic cell death markers in patients with acute liver injury
    Darren G N Craig
    Royal Infirmary of Edinburgh, Little France, Edinburgh, UK
    Liver Int 31:1127-36. 2011
    ..Nucleosomes, formed during apoptosis, can complex with high-mobility group box 1 (HMGB1) protein and may play a pathogenic role in liver injury...
  94. pmc IRE1α activation protects mice against acetaminophen-induced hepatotoxicity
    Kyu Yeon Hur
    Deartment of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Exp Med 209:307-18. 2012
    ..b>Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in young adults in the United States and is ..
  95. ncbi Maternal use of acetaminophen, ibuprofen, and acetylsalicylic acid during pregnancy and risk of cryptorchidism
    Morten Søndergaard Jensen
    Perinatal Epidemiology Research Unit, Departments of Obstetrics and Pediatrics, Aarhus University Hospital, Skejby, Denmark
    Epidemiology 21:779-85. 2010
    Cyclooxygenase (COX) inhibitors-acetaminophen, ibuprofen and acetylsalicylic acid-have endocrine-disruptive properties in the rainbow trout...
  96. ncbi Acetaminophen use and the risk of asthma in children and adults: a systematic review and metaanalysis
    Mahyar Etminan
    Pharmacoepidemiology Unit, Center for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada
    Chest 136:1316-23. 2009
    Epidemiologic studies have identified an increased risk of asthma with acetaminophen use, but the results have been conflicting. We sought to quantify the association between acetaminophen use and the risk of asthma in children and adults.
  97. ncbi Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse
    Donna M Dambach
    Department of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Hepatology 35:1093-103. 2002
    ..In the present studies, we used CCR2 knockout (CCR2-/-) mice to examine the role of MCP-1 in acetaminophen-induced macrophage accumulation in the liver, expression of inflammatory cytokines, and hepatotoxicity...
  98. ncbi Atorvastatin may have no effect on acute phase reaction in children after intravenous bisphosphonate infusion
    Tarak Srivastava
    Bone and Mineral Disorder Clinic, Section of Nephrology, Children s Mercy Hospital and University of Missouri, Kansas City, Missouri 64108, USA
    J Bone Miner Res 24:334-7. 2009
    ..We measured pain using a visual analog pain scale at five time points in 0-48 h, oxycodone use for pain, acetaminophen for fever, C-reactive protein (CRP), and total and percent gammadeltaT-cells...
  99. ncbi Acetaminophen induced renal injury via oxidative stress and TNF-alpha production: therapeutic potential of arjunolic acid
    Jyotirmoy Ghosh
    Division of Molecular Medicine, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata 700054, West Bengal, India
    Toxicology 268:8-18. 2010
    b>Acetaminophen (APAP) causes acute and chronic renal failure. The mechanisms leading to hepatic injury have been extensively studied, but the molecular mechanisms regarding APAP-induced nephro-toxicity are poorly defined...
  100. ncbi Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice
    Lisa A McConnachie
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
    Toxicol Sci 99:628-36. 2007
    The analgesic and antipyretic drug acetaminophen (APAP) is bioactivated to the reactive intermediate N-acetyl-p-benzoquinoneimine, which is scavenged by glutathione (GSH)...
  101. ncbi Propolis reverses acetaminophen induced acute hepatorenal alterations: a biochemical and histopathological approach
    Satendra Kumar Nirala
    Reproductive Biology and Toxicology Laboratory, School of Studies in Zoology, Jiwaji University, Gwalior M P, India
    Arch Pharm Res 31:451-61. 2008
    ..has been conducted to evaluate the curative effect of propolis extract, a honey bee-hive product, against acetaminophen (APAP) induced oxidative stress and dysfunction in liver and kidney...

Research Grants68

  1. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..abstract_text> ..
  2. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..abstract_text> ..
  3. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Although oxidative stress is implicated in both acute acetaminophen-induced liver failure and chronic liver diseases, cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic ..
  4. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..numbers of prescription drugs such as cholesterol-lowering drugs and over-the-counter medications, including acetaminophen, can potentially cause liver toxicity and, thereby, require medical liver function checks...
  5. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..for their ability to localize in lysosomes and prevent lysosomal membrane disruption and iron release after acetaminophen- induced oxidative stress...
  6. Sterile Hepatic Inflammation
    Wajahat Zafar Mehal; Fiscal Year: 2012
    ..The SIR is an important component of injury in a wide range of diseases including acetaminophen (APAP) hepatotoxicity, as well as alcoholic and non-alcoholic steatohepatitis...
  7. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..Acute liver failure (ALF) is commonly associated with the alcohol-acetaminophen syndrome, its clinical course is unpredictable and polarizing, with death as the outcome in a large percentage ..
  8. Research Center for Pharmacology &Drug Toxicology
    L Jackson Roberts; Fiscal Year: 2013
    ..The proposed research in Project 1 is an evolution of our previous studies in the Center which elucidated that acetaminophen inhibits hemoprotein redox cycling induced lipid peroxidation...
  9. Dichotomous Roles of Thrombin in Acetaminophen Hepatotoxicity
    ROBERT ANDREW ROTH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overdose with acetaminophen (APAP) is the most common cause of acute liver failure in humans...
  10. Novel Small Molecules For Acute Liver Failure
    Prakash Narayan; Fiscal Year: 2009
    ..Commonly associated with the alcohol-acetaminophen syndrome, its clinical course is unpredictable and polarizing, with death as the outcome in a large percentage ..
  11. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    ..Project 3 builds on findings that acetaminophen inhibits heme protein-catalyzed lipid peroxidation and will determine the molecular basis for this effect...
  12. Oxygen/Nitrogen Stress in Acetaminophen Hepatotoxicity
    Jack A Hinson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) poisoning is the most common cause of acute liver failure in the U.S...
  13. MECHANISM OF ACTION OF A MAJOR FOLATE ENZYME
    Sergey A Krupenko; Fiscal Year: 2013
    ..Moreover, the inhibition of the enzyme associated with acetaminophen overdose or alcohol consumption is believed to contribute to liver toxicity...
  14. Redox Triggering of Glomerular NALP3 Inflammasomes in Hyperhomocysteinemia
    Justine M Abais; Fiscal Year: 2013
    ..inflammasome has recently been linked to non-immune, metabolic diseases such as diabetes, gout, silicosis, and acetaminophen-induced liver toxicity...
  15. Dipstick Assay for Detection of Acetaminophen Protein Adducts
    Laura P James; Fiscal Year: 2010
    ..goal of this STTR proposal is to develop a rapid, sensitive, and specific diagnostic test that can identify acetaminophen (APAP) protein adducts in human sera...
  16. Investigation of the liver progenitor cell niche using CK19 lineage tracing
    EUGENE SCOTT SWENSON; Fiscal Year: 2011
    ..CK19+ hepatic progenitor cells during liver regeneration after injury by 1) partial hepatectomy and 2) acute acetaminophen injury...
  17. Cellular Mechanisms of Hepatotoxicity.
    Neil Kaplowitz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) toxicity is the leading cause of acute liver failure...
  18. Liver innate immunity in drug-induced liver disease.
    Zhang Xu Liu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) hepatotoxicity is currently the most common cause of acute liver failure in the United States...
  19. Discontinuing NSAIDs in Veterans with Knee Osteoarthritis
    Liana Fraenkel; Fiscal Year: 2013
    ..Though short-term studies have demonstrated that NSAIDs are more effective than placebo and acetaminophen, there are no long-term data supporting their use...
  20. CD24 Polymorphism and Acetaminophen Toxicity
    Pan Zheng; Fiscal Year: 2010
    ..we identified CD24-Siglec10/G interaction as a key regulator for host response to necrosis induced by acetaminophen, which is (Science. 2009 Mar 5...
  21. The Fetal and Childhood Environment, Oxidative Balance, Inflammation and Asthma
    Emily Oken; Fiscal Year: 2013
    ..life exposures to sources of oxidative stress/inflammation (adiposity, cigarette smoke, traffic pollution, and acetaminophen). Conversely, higher prenatal maternal antioxidant dietary intake reduced early-life wheeze risk...
  22. Identification of new mechanistic biomarkers of adverse responses to acetaminophe
    Laura P James; Fiscal Year: 2013
    b>Acetaminophen (APAP) is the most common drug used for the treatment of pain and fever in the world today and is also the leading cause of acute liver failure in the United States...
  23. Role of IRF3 and RXRa Crosstalk in Host Response to Viral Infections
    Genhong Cheng; Fiscal Year: 2013
    ..a hepatotoxicity disease that occurs when children are given aspirin in the context of a viral infection, or acetaminophen (APAP)-induced hepatotoxicity, which accounts for about half of the acute liver failures in US...
  24. Prostaglandins and Cerebellum Development
    Margaret M McCarthy; Fiscal Year: 2013
    ..Understanding how inflammation and the medications taken to treat it impact on the developing cerebellum will provide important mechanistic insight into the origins of these disorders of mental health. ..
  25. The Role of miR-122 in Alcoholic Liver Disease
    Abhishek Satishchandran; Fiscal Year: 2013
    ..On day 28 mice will be withdrawn from alcohol and given 150- mg/kg acetaminophen (APAP). Mice will be sacrificed on day 30 to assess regeneration...
  26. CCR2 in Hematopoietic Stem Cell Homing, Macrophage Polarization and Organ Repair
    Israel F Charo; Fiscal Year: 2013
    ..not CCR2-/- stem cells were actively recruited to the peritoneum, and to the liver following administration of acetaminophen. Significantly, infusion of CCR2+/+, but not CCR2-/- HSCs/HPCs accelerated the resolution of liver damage, and ..
  27. XENOBIOTICS AND PRIMARY BILIARY CIRRHOSIS
    MERRILL E GERSHWIN; Fiscal Year: 2013
    ..One such common electrophilic agent is acetaminophen (APAP)...
  28. Mechanisms of Liver Regeneration After Acetaminophen-Induced Acute Liver Failure
    Udayan Apte; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Overdose of acetaminophen (APAP), the popular analgesic and antipyretic agent, is the most common cause of acute liver failure (ALF) in the developing countries...
  29. Mitochondrial Acetylation Modification in Regulating Drug-Induced Liver
    Zhongping Lu; Fiscal Year: 2013
    ..We recenfly found that'SIRTSr/-mice are i-esistant to acetaminophen-induced liver injury...
  30. Pediatric Adverse Drug Reactions in NASH
    Nathan J Cherrington; Fiscal Year: 2013
    ....
  31. Serum Apoptosis Markers as Biomarkers in Acute Liver Failure
    Raymond T Chung; Fiscal Year: 2010
    ..affects approximately 2,000 people/year in the United States from a variety of different etiologies, including acetaminophen, viral hepatitis, drug-induced liver injury and indeterminate causes...
  32. Risk Factors for Hearing Loss
    Gary C Curhan; Fiscal Year: 2013
    ..Aspirin, acetaminophen and ibuprofen are the three most commonly used drugs in the U.S...
  33. Investigation of the role of DAMP molecules in the pathogenesis of Liver Injury
    BRITTANY V MURPHY; Fiscal Year: 2012
    ..b>Acetaminophen (APAP)-induced liver injury in mice will be used as a model, and the specific aims of the proposed studies ..
  34. Virtual High Throughput Screening: Specific Mechanism-based Inhibitors of CYP2E1
    Haoming Zhang; Fiscal Year: 2012
    ..monooxygenase that catalyzes the oxidation of a number of hepatotoxins and procarcinogens including ethanol, acetaminophen, nitrosamines, and carbon tetrachloride, among many others...
  35. The Hepatoprotective Role of the Orphan Nuclear Receptor LXR
    Wen Xie; Fiscal Year: 2010
    ..b>Acetaminophen (APAP) or Tylenol, an over-the-counter medication, is a xenobiotic toxicant whose overdose is the leading ..
  36. Antibiofilm/Antimicrobial Combination for Infections Associated with Vascular Cat
    Mohammad D Mansouri; Fiscal Year: 2010
    ..of amino acid cysteine and a potent antioxidant, commonly used as a systemic remedy against toxicity with acetaminophen, is also used for inhalation therapy in patients with chronic bronchitis by breaking up the mucus...
  37. Regulation of Toll-like Receptor 4 in Acute Inflammatory Disease
    JUSTIN EDDIE JUSKEWITCH; Fiscal Year: 2012
    ..intact ECM and its degradation in 3 murine models of SIRS (endotoxemia, cerulein-induced acute pancreatitis, acetaminophen-induced acijte hepatitis)...
  38. Transporter Expression in Response to Hepatotoxicants
    Jose E Manautou; Fiscal Year: 2013
    ABSTRACT Although knowledge on acetaminophen (APAP) hepatotoxicity has advanced significantly during the last three decades, the precise mechanism of toxicity remains unknown...
  39. A Multi-Center Group to Study Acute Liver Failure
    William M Lee; Fiscal Year: 2013
    ..samples on more than 1,600 patients and conducted a randomized controlled trial of N-acetylcysteine for non-acetaminophen acute liver failure (ALF)...
  40. Non-cancer pain and cognitive impairment: A disabling relationship
    Joseph W Shega; Fiscal Year: 2012
    ..cognitive status modifies this relationship;(4) compare the efficacy of long-acting opioid to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate non-cancer knee ..
  41. Metabolism and Toxicity of Acetaminophen in Preterm Infants
    JOHANNES NICOLAAS VAN DEN ANKER; Fiscal Year: 2013
    ..an increasing appreciation for opioid-associated adverse events has prompted an increase in the use of acetaminophen (APAP) for treating pain in preterm neonates...
  42. Inflamation and the Risk of Endometrial Cancer
    Akila Viswanathan; Fiscal Year: 2010
    ..anti-inflammatory drugs, in relation to the risk of endometrial cancer and contrast these results to those of acetaminophen, which is not an anti-inflammatory medication...
  43. Assessing the effect of FDA advisories on provider, patient, and firm behavior
    G Caleb Alexander; Fiscal Year: 2012
    ..to date has examined the impact of select warnings on the aggregate prescribing rates of drugs such as acetaminophen, droperidol, cisapride, and more recently, selective serotonin reuptake inhibitors...
  44. COX Regulation of Allergic Sensitization and Immune Memory Generation
    Weisong Zhou; Fiscal Year: 2009
    ..studies reveals an association between frequent use of the cyclooxygenase (COX) inhibiting drug acetaminophen and increased risk of developing allergic diseases, suggesting a possible role of COX inhibition in causing ..
  45. Adduct Dipstick for Diagnosis of Acetaminophen Toxicity
    Laura P James; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever in the world today...
  46. Characterization of the Role of mTOR Signaling in Opiate Action
    MICHELLE SUZANNE MAZEI ROBISON; Fiscal Year: 2010
    ..Given that the most highly prescribed drug in the U.S. in 2005 was an opiate, hydrocodone with acetaminophen, and that the non-prescription use has also increased, especially in adolescents where use of the opiates ..
  47. The role of cyclooxygenase in the adaptive immune response and tolerance
    Ray Stokes Peebles; Fiscal Year: 2013
    ..studies reveals an association between frequent use of the cyclooxygenase (COX) inhibiting drug acetaminophen and increased risk of developing allergic diseases, suggesting a possible role of COX inhibition in causing ..
  48. 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Phy
    LAWRENCE F CHU; Fiscal Year: 2013
    ..opioids are among the most common medications prescribed by physicians in the US2 and Vicodin (hydrocodone/acetaminophen) -- with 100 million prescriptions in 2005 alone -- is the most commonly prescribed medication of any category...
  49. Human Lactoferrin in Acetaminophen Overdose-Induced Liver Failure
    Cynthia Ju; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): An acute or cumulative overdose of acetaminophen (APAP), following either therapeutic overdose or suicide attempts, can cause severe liver damage with the potential to progress to liver failure...
  50. Outcomes Research in Rheumatic Diseases: A Mentoring Program
    Maria E Suarez-Almazor; Fiscal Year: 2013
    ..of patient decision aids with respect to musculoskeletal conditions;(3) Utilization and toxicity of acetaminophen, a R18 grant funded by AHRQ;and (4) Quality of care for osteoporosis in patients with cancer...
  51. The effects of acetaminophen on the rewarding properties of hydrocodone in rats
    Arbi Nazarian; Fiscal Year: 2010
    ..a combination of two compounds: an opioid agonist, such as hydrocodone, plus a non-narcotic analgesic, such as acetaminophen. Although the combination analgesic formulations have been effective in treating pain, it is yet unknown ..
  52. Pharmaceutical polymorphs: an electronic approach
    Mikhail Yu Antipin; Fiscal Year: 2010
    ..We plan to grow polymorphs of five known pharmaceutical/bioactive compounds: acetaminophen, phenobarbital, diclofenac acid, glycine and thalidomide...
  53. Noninvasive Methemoglobin Monitoring Technology
    LEONARD WINCHESTER; Fiscal Year: 2007
    ..by environmental or work-related chemical exposures, and from pharmaceutical agents such as local anesthetics, acetaminophen, and drugs containing nitrites and/or nitrates...
  54. A Controlled Trial of NAC for Cocaine Dependence
    Robert Malcolm; Fiscal Year: 2009
    ..MAC is FDA-approved for the treatment of cystic fibrosis and acetaminophen overdose...
  55. Understanding the Effects of Chronic Opioids Therapy in Humans
    LAWRENCE F CHU; Fiscal Year: 2013
    ..opioids are among the most common medications prescribed by physicians in the US and Vicodin (hydrocodone/acetaminophen) is the most prescribed medication of any category...
  56. Novel Azaborine Derivatives Predicted to Eliminate Acetaminophen Hepatotoxicity
    DONALD ALLEN UPSON; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Overdose on acetaminophen (more commonly known by the brand name Tylenol(R)), accounts for 56,000 emergency room visits and more than 450 deaths annually in the USA...
  57. Preclinical Development of SCP-123 for Neuropathic Pain
    KENNETH WAYNE NARDUCY; Fiscal Year: 2010
    ..Neuropathic pain syndromes are for the most part resistant to traditional analgesic treatments with NSAIDs, acetaminophen, or opiate medications (eg, morphine, codeine)...
  58. Novel drug combinations for the management of pain
    KENNETH NARDUCY; Fiscal Year: 2007
    ..Combinations of acetaminophen with opioids (i.e., hydrocodone, codeine) are frequently prescribed for acute and chronic pain management...
  59. Liver innate immunity in drug-induced liver disease
    Zhang Xu Liu; Fiscal Year: 2006
    ..The candidate proposes to begin research in this field by focusing on the hepatotoxicity of acetaminophen (APAP), since it is a common cause of acute liver failure and serves as a prototype...
  60. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..Accidental and purposeful acetaminophen overdose accounts for 20 percent of acute liver failure cases in the U.S...
  61. A Pharmacokinetic Study of glucosamine and chondroitin
    Christopher Jackson; Fiscal Year: 2005
    ..Traditional treatments, most often nonsteroidal anti-inflammatory drugs and nonnarcotic analgesics such as acetaminophen, produce variable efficacy and may be complicated by significant toxicity...
  62. Analgesic Use and Kidney Cancer
    Eunyoung Cho; Fiscal Year: 2009
    ..Analgesics are a diverse group of drugs used to relieve pain, including acetaminophen and non-steroidal anti- inflammatory drugs (NSAIDs)...
  63. Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training
    CATHERINE JANKOWSKI; Fiscal Year: 2007
    ..b>Acetaminophen (ACET) is an analgesic that has traditionally been thought to have only weak, if any, inhibitory effects on ..
  64. ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILURE
    Gary Curhan; Fiscal Year: 2002
    ..studies have reported an increased risk of renal dysfunction associated with consumption of large amounts of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) but not aspirin...
  65. Alcohol and Acetaminophen Hepatotoxicity
    Jacqueline Sinclair; Fiscal Year: 2006
    ..2. To investigate the effect of methylxanthines, which increase CYP3A activity but decrease CYP1A2, on alcohol-mediated APAP hepatotoxicity in wild-type and CYP1A2 knockout mice. ..
  66. Cellular Device for the Treatment of Acute Liver Failure
    Arno W Tilles; Fiscal Year: 2013
    ..PET)-guided optimization of cellular coatings;and (2) To perform a dose escalation therapeutic trial in an acetaminophen-induced liver failure model in dogs...
  67. Efficacy of Acupuncture with PT for Knee Osteo-Arthritis
    John Farrar; Fiscal Year: 2005
    ..There is clinical trial evidence of efficacy for the standard treatments of acetaminophen and NSAIDs, and exercise physical therapy (EPT), which is usually added when the patient develops functional ..
  68. DRUG METABOLISM IN THE EYE
    Hitoshi Shichi; Fiscal Year: 2001
    ..Mice pretreated with cytochrome P450 (CYP) inducers developed cataracts when overdosed with acetaminophen (APAP) but no changes occur in posterior tissues...