acrylamides

Summary

Summary: Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.

Top Publications

  1. ncbi FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
    Max Hasmann
    Fujisawa GmbH, Neumarkter Strasse 61, 81673 Munich, Germany
    Cancer Res 63:7436-42. 2003
  2. ncbi The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
    Aimable Nahimana
    Service of Hematology, University Hospital of Lausanne, Lausanne, Switzerland
    Blood 113:3276-86. 2009
  3. pmc First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium
    Anne Sophie Kerbrat
    UPS, UMR152 UPS IRD PHARMA DEV, Toulouse University, 118 route de Narbonne, Toulouse Cedex 9, France
    Mar Drugs 9:543-60. 2011
  4. ncbi A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell line
    Mirella Bellocci
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, I 41100 Modena, Italy
    Anal Biochem 374:48-55. 2008
  5. ncbi Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma
    Joachim Drevs
    Department of Medical Oncology, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Federal Republic of Germany
    Anticancer Res 23:4853-8. 2003
  6. ncbi Palytoxin detection and quantification using the fluorescence polarization technique
    A Alfonso
    Department of Pharmacology, Veterinary School, 27002 Lugo, Spain
    Anal Biochem 424:64-70. 2012
  7. pmc The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario Via C, Valeria Gazzi, 98100 Messina, Italy
    J Neuroinflammation 9:66. 2012
  8. ncbi Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells
    Basant Kumar Thakur
    Department of Pediatrics, Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biochem Biophys Res Commun 424:371-7. 2012
  9. pmc The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
    Lan Dan
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Haematologica 97:551-9. 2012
  10. pmc Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
    Michele Cea
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 6:e22739. 2011

Research Grants

  1. CYTOSKELETAL TARGETS OF NEURONAL/TESTICULAR TOXICANTS
    Kim Boekelheide; Fiscal Year: 1993
  2. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
  3. Negative Regulators: Key Determinants in Carcinogenesis
    ELIZABETH WATTENBERG; Fiscal Year: 2009
  4. Ca2+ channels in non-excitable cells
    William Schilling; Fiscal Year: 2006
  5. Bcr-Abl thiophosphorylation profiling in CML using MALDI
    Laurie Parker; Fiscal Year: 2006
  6. Polymers with time-dependent properties for drug deliver
    Brent Vernon; Fiscal Year: 2007
  7. Function and regulation of cardiac Na transporters
    Donald Hilgemann; Fiscal Year: 2008
  8. HEART-LUNG PHYSIOLOGY: MOLECULAR-SYSTEMIC INTEGRATION
    William Schilling; Fiscal Year: 2008
  9. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
  10. Targeted Proapoptotic Anticancer Drug Delivery Systems
    Tamara Minko; Fiscal Year: 2010

Detail Information

Publications256 found, 100 shown here

  1. ncbi FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
    Max Hasmann
    Fujisawa GmbH, Neumarkter Strasse 61, 81673 Munich, Germany
    Cancer Res 63:7436-42. 2003
    ....
  2. ncbi The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies
    Aimable Nahimana
    Service of Hematology, University Hospital of Lausanne, Lausanne, Switzerland
    Blood 113:3276-86. 2009
    ..The results support the potential of APO866 for treating hematologic malignancies...
  3. pmc First evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium Trichodesmium
    Anne Sophie Kerbrat
    UPS, UMR152 UPS IRD PHARMA DEV, Toulouse University, 118 route de Narbonne, Toulouse Cedex 9, France
    Mar Drugs 9:543-60. 2011
    ..The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed...
  4. ncbi A cytolytic assay for the measurement of palytoxin based on a cultured monolayer cell line
    Mirella Bellocci
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, I 41100 Modena, Italy
    Anal Biochem 374:48-55. 2008
    ..We conclude that our cytolytic assay based on the use of MCF-7 cell monolayers is a viable alternative to animal-based methods for the determination of palytoxin and its congeners in contaminated materials...
  5. ncbi Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma
    Joachim Drevs
    Department of Medical Oncology, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Federal Republic of Germany
    Anticancer Res 23:4853-8. 2003
    ..FK-866 has antitumoral and antimetastatic activity in RENCA mice. Furthermore, this is the first report to describe a strong antiangiogenic potency of FK-866...
  6. ncbi Palytoxin detection and quantification using the fluorescence polarization technique
    A Alfonso
    Department of Pharmacology, Veterinary School, 27002 Lugo, Spain
    Anal Biochem 424:64-70. 2012
    ..The LOQ (limit of quantification) of the method is 10nM and the LOD (limit of detection) is 2 nM. This new PLT detection method is easier, faster, and more reliable than the other methods described to date...
  7. pmc The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica Policlinico Universitario Via C, Valeria Gazzi, 98100 Messina, Italy
    J Neuroinflammation 9:66. 2012
    ..Given the role of inflammatory responses in spinal cord injury (SCI), the effect of NAMPT inhibitors was examined in this setting...
  8. ncbi Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells
    Basant Kumar Thakur
    Department of Pediatrics, Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biochem Biophys Res Commun 424:371-7. 2012
    ....
  9. pmc The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells
    Lan Dan
    Department of Molecular Hematopoiesis, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Haematologica 97:551-9. 2012
    ..Inhibitors of nicotinamide phosphoribosyltransferase have recently been validated as therapeutic targets in leukemia, but the mechanism of leukemogenic transformation downstream of this enzyme is unclear...
  10. pmc Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells
    Michele Cea
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 6:e22739. 2011
    ..In conclusion, NAD(+)-independent HDACs and sirtuins cooperate in leukemia cells to avoid apoptosis. Combining sirtuin with HDAC inhibitors results in synergistic antileukemic activity that could be therapeutically exploited...
  11. ncbi Complex palytoxin-like profile of Ostreopsis ovata. Identification of four new ovatoxins by high-resolution liquid chromatography/mass spectrometry
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Rapid Commun Mass Spectrom 24:2735-44. 2010
    ....
  12. ncbi Nampt/PBEF/visfatin and cancer
    Tie qiang Bi
    Department of General Surgery, The First Affiliated Hospital, Medical School of Xi an Jiaotong University, Xi an, Shaanxi, China
    Cancer Biol Ther 10:119-25. 2010
    ..This review will focus on its role in carcinogenesis and cancer progression and its inhibitors as therapeutic target for cancer treatment...
  13. ncbi A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor
    Uffe Høgh Olesen
    Experimental Pathology Unit, Rigshospitalet 3733, Biocenter, Ole Maaloes Vej 5, Copenhagen, Denmark
    Mol Cancer Ther 9:1609-17. 2010
    ..In conclusion, the combination of high doses of APO866 with rescue by nicotinic acid may significantly increase the therapeutic potential in a subset of cancers with low expression of nicotinic acid phosphoribosyltransferase...
  14. ncbi A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect
    Kazunori Yasuda
    Department of Sports Medicine and Joint Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Macromol Biosci 9:307-16. 2009
    ..This study prompted an innovative strategy in the field of joint surgery to repair an osteochondral defect using an advanced, high-function hydrogel...
  15. ncbi The Genoa 2005 outbreak. Determination of putative palytoxin in Mediterranean Ostreopsis ovata by a new liquid chromatography tandem mass spectrometry method
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Anal Chem 78:6153-9. 2006
    ..It is suggested that putative palytoxin was the causative agent responsible for patients' symptoms and demonstrated for the first time the presence of such a toxin in Italian waters...
  16. ncbi Ostreopsis sp., a possible origin of palytoxin (PTX) in parrotfish Scarus ovifrons
    Shigeto Taniyama
    Graduate School of Science and Technology, Nagasaki University, Nagasaki 852 8521, Japan
    Toxicon 42:29-33. 2003
    ..in October 1997 at Tokushima Prefecture. From the above results, it can be strongly postulated that the dinoflagellate Ostreopsis sp. is the origin of PTX which is sequestered by the parrotfish S. ovifrons through food chain...
  17. ncbi Induction of spontaneous hyaline cartilage regeneration using a double-network gel: efficacy of a novel therapeutic strategy for an articular cartilage defect
    Nobuto Kitamura
    Department of Sports Medicine and Joint Surgery, Hokkaido University, Kita ku, Sapporo, 060 8638, Japan
    Am J Sports Med 39:1160-9. 2011
    ..A double-network (DN) gel, which was composed of poly-(2-acrylamido-2-methylpropanesulfonic acid) and poly-(N,N'-dimetyl acrylamide) (PAMPS/PDMAAm), has the potential to induce chondrogenesis both in vitro and in vivo...
  18. pmc The ion pathway through the opened Na(+),K(+)-ATPase pump
    Ayako Takeuchi
    Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, New York 10065, USA
    Nature 456:413-6. 2008
    ....
  19. pmc Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE
    Santina Bruzzone
    Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Genoa, Italy
    PLoS ONE 4:e7897. 2009
    ..In conclusion, Nampt inhibitors (and possibly Sirt6 inhibitors) could be used to modulate T cell-mediated immune responses and thereby be beneficial in immune-mediated disorders...
  20. ncbi AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties
    Narender R Gavva
    Department of Neuroscience, Amgen Inc, MS 29 2 B, Thousand Oaks, CA 91320 1799, USA
    J Pharmacol Exp Ther 313:474-84. 2005
    ..AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain...
  21. ncbi Mouse bioassay for palytoxin. Specific symptoms and dose-response against dose-death time relationships
    P Riobo
    Grupo de Fitoplancton Tóxico, Instituto Investigacións Mariñas CSIC Eduardo Cabello 6, 36208 Vigo, Galicia, Spain
    Food Chem Toxicol 46:2639-47. 2008
    ..Herein is demonstrated that the logistic equation and the accumulative function of Weibull's distribution (with the modifications proposed) generate satisfactory toxicological descriptions in all the respects...
  22. ncbi New palytoxin-like molecules in Mediterranean Ostreopsis cf. ovata (dinoflagellates) and in Palythoa tuberculosa detected by liquid chromatography-electrospray ionization time-of-flight mass spectrometry
    Rachele Rossi
    Istituto Zooprofilattico Sperimentale del Mezzogiorno, Via Salute 2, 80055 Portici, Italy
    Toxicon 56:1381-7. 2010
    ..cf. ovata. Another new palytoxin was detected in the standard material from Palythoa tuberculosa provided by Wako Chemicals...
  23. ncbi Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents
    Javed A Khan
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Struct Mol Biol 13:582-8. 2006
    ..Contrary to current knowledge, the structures show that FK866 should compete directly with the nicotinamide substrate. Our structural and biochemical studies provide a starting point for the development of new anticancer agents...
  24. ncbi The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor
    Kyle Holen
    University of Wisconsin Paul P Carbone Comprehensive Cancer Center, University Hospital and Clinics, 600 Highland Ave K4 528, Madison, WI 53792, USA
    Invest New Drugs 26:45-51. 2008
    ..FK866 is a potent inhibitor or NAD synthesis. This first-in-human study was performed to determine the maximum-tolerated dose, toxicity profile, and pharmacokinetics on a 96-h continuous infusion schedule...
  25. ncbi H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration
    Dany S Adams
    Center for Regenerative and Developmental Biology, Forsyth Institute, and Developmental Biology Department, Harvard School of Dental Medicine, 140 The Fenway, Boston, MA 02115, USA
    Development 134:1323-35. 2007
    ..Control of H(+) flows represents a very important new modality that, together with traditional biochemical approaches, may eventually allow augmentation of regeneration for therapeutic applications...
  26. ncbi Study of inhibitory effects and action mechanism of the novel fungicide pyrimorph against Phytophthora capsici
    Xiaojing Yan
    Key Laboratory of Pesticide Chemistry and Application Technology, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, People s Republic of China
    J Agric Food Chem 58:2720-5. 2010
    ..These results suggested pyrimorph exhibited multiple modes of action including impairment of the energy generation system and effect on cell wall biosynthesis directly or indirectly...
  27. ncbi Stereostructure and biological activity of 42-hydroxy-palytoxin: a new palytoxin analogue from Hawaiian Palythoa subspecies
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano, 49, 80131 Napoli, Italy
    Chem Res Toxicol 22:1851-9. 2009
    ..toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities...
  28. pmc Ouabain affinity determining residues lie close to the Na/K pump ion pathway
    Pablo Artigas
    Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:12613-8. 2006
    ..The results suggest a method for mapping the footprint of bound cardiotonic steroid on the extracellular surface of the Na/K pump...
  29. ncbi Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps
    Pablo Artigas
    Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 986:116-26. 2003
    ..We review that work here and provide evidence that the pore of the PTX-induced pump-channel has a diameter > 6 A...
  30. ncbi The cytolytic and cytotoxic activities of palytoxin
    Mirella Bellocci
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, via G Campi 287, I 41125 Modena, Italy
    Toxicon 57:449-59. 2011
    ....
  31. ncbi The cytotoxic effect of palytoxin on Caco-2 cells hinders their use for in vitro absorption studies
    M Pelin
    Department of Life Sciences, University of Trieste, via Valerio 6, 34127 Trieste, Italy
    Food Chem Toxicol 50:206-11. 2012
    ..These results indicate that, due to the high susceptibility to PLTX cytotoxic effects, Caco-2 cells do not represent an appropriate and reliable model for investigating intestinal barrier permeation by this toxin...
  32. ncbi Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, Napoli, Italy
    J Am Soc Mass Spectrom 19:111-20. 2008
    ..We report also on the analysis of cultured O. ovata, which was necessary to unequivocally demonstrate that putative palytoxin and ovatoxin-a contained in field samples were actually produced by O. ovata itself...
  33. ncbi Toxin-producing Ostreopsis cf. ovata are likely to bloom undetected along coastal areas
    Martin Pfannkuchen
    Institute Ruđer Bošković, Center for Marine Research, Giordano Palliaga 5, 52210 Rovinj, Croatia
    Environ Sci Technol 46:5574-82. 2012
    ..Increased monitoring efforts are therefore required to understand the ecology and toxicology of those bloom events and reduce their negative impact on coastal populations...
  34. ncbi Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor
    C Vale-Gonzalez
    Departamento de Farmacologia, Universidad de Santiago de Compostela, Campus Universitario s n 27002 Lugo, Spain
    Toxicon 50:541-52. 2007
    ....
  35. pmc Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models
    Jing Bi
    Dalton Cardiovascular Research Center, University of Missouri Columbia, Missouri 65211, USA
    J Neurochem 120:334-46. 2012
    ..We conclude that PBEF has a neuroprotective effect in ischemia through its enzymatic activity for NAD⁺ production that can ameliorate mitochondrial dysfunction...
  36. ncbi Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery
    Javed A Khan
    Columbia University, Department of Biological Sciences, New York, NY 10027, USA
    Expert Opin Ther Targets 11:695-705. 2007
    ..This review summarizes the existing knowledge on NAD(+) metabolic enzymes, with emphasis on their relevance for drug discovery...
  37. pmc Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands
    Pablo Artigas
    Laboratory of Cardiac Membrane Physiology, Rockefeller University, New York, NY 10021 6399, USA
    J Gen Physiol 123:357-76. 2004
    ..5 A wide. Enhanced understanding of palytoxin action now allows its use for examining the structures and mechanisms of the gates that occlude/deocclude transported ions during the normal Na/K pump cycle...
  38. ncbi Effects of palytoxin on cation occlusion and phosphorylation of the (Na+,K+)-ATPase
    M T Tosteson
    Laboratory for Membrane Transport, Department of Cell Biology, Harvard Medical School, One Kendall Square, Building 600 Third Floor, Cambridge, MA 02139, USA
    J Membr Biol 192:181-9. 2003
    ....
  39. ncbi Polymer gel dosimeters with reduced toxicity: a preliminary investigation of the NMR and optical dose-response using different monomers
    R J Senden
    Department of Chemical Engineering, Queen s University, Kingston, Ont K7L 3N6, Canada
    Phys Med Biol 51:3301-14. 2006
    ..The optical dose-response, measured in terms of the attenuation coefficient for each polymer gel dosimeter, showed potential for the use of optical imaging techniques in future studies...
  40. ncbi Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
    David Oupicky
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, B15 2TT, UK
    Mol Ther 5:463-72. 2002
    ..Multivalent PHPMA coating allows, for the first time, considerably extended circulation time using polyplex systems-a prerequisite for systemic gene delivery...
  41. ncbi Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells
    Cristina Travelli
    Department of Chemical, Food, Pharmaceutical, and Pharmacological Sciences, Universita del Piemonte Orientale, Novara, Italy
    J Pharmacol Exp Ther 338:829-40. 2011
    ..Even more strikingly, cotreatment with etoposide/cisplatin and FK866 unmasks an effect on mitochondrial NAD depletion...
  42. ncbi Na+/K+-ATPase inhibitor palytoxin enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-dependent mechanisms
    Anabel Pérez-Gómez
    Departament of Biochemistry and Molecular Biology, Institute of Biotechnlogy of Asturias, University of Oviedo, 33006 Oviedo, Spain
    J Neurochem 114:28-38. 2010
    ..They also raise reasonable concern about possible risks for human health associated to the ingestion of low amounts of phycotoxins PTX and domoic acid in food...
  43. ncbi Comparative growth and toxin profile of cultured Ostreopsis ovata from the Tyrrhenian and Adriatic Seas
    Franca Guerrini
    Centro Interdipartimentale di Ricerca per le Scienze Ambientali, Universita di Bologna, via S Alberto 163, 48100 Ravenna, Italy
    Toxicon 55:211-20. 2010
    ....
  44. ncbi Palytoxin-induced cell death cascade in bovine aortic endothelial cells
    William P Schilling
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Am J Physiol Cell Physiol 291:C657-67. 2006
    ..These results demonstrate that PTX initiates a cell death cascade characteristic of Ca(2+) overload...
  45. ncbi Palytoxin action on the Na(+),K(+)-ATPase and the disruption of ion equilibria in biological systems
    Gian Paolo Rossini
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, via G Campi 287, I 41125 Modena, Italy
    Toxicon 57:429-39. 2011
    ....
  46. ncbi Ostreopsis ovata and human health: epidemiological and clinical features of respiratory syndrome outbreaks from a two-year syndromic surveillance, 2005-06, in north-west Italy
    P Durando
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, San Martino Hospital, University of Genoa, Genoa, Italy
    Euro Surveill 12:E070607.1. 2007
  47. ncbi Palytoxin toxicology: animal studies
    Rex Munday
    AgResearch, Ruakura Agricultural Research Centre, Private Bag 3123, Hamilton, New Zealand
    Toxicon 57:470-7. 2011
    ..Information required for the risk assessment of palytoxin and its derivatives is by no means complete, and recommendations for further studies, which may better inform regulatory decisions regarding these substances, are also discussed...
  48. pmc Modulation of protein kinase signaling cascades by palytoxin
    Elizabeth V Wattenberg
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Mayo Mail Code 807, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Toxicon 57:440-8. 2011
    ..The studies discussed in this review investigated how palytoxin stimulates MAP kinase activity and, in turn, how MAP kinases mediate the response of cells to palytoxin...
  49. ncbi Effects of the marine toxin palytoxin on human skin keratinocytes: role of ionic imbalance
    M Pelin
    Department of Materials and Natural Resources, University of Trieste, Via A Valerio 6, 34127 Trieste, Italy
    Toxicology 282:30-8. 2011
    ..The PLTX concentrations inducing cytotoxicty seem to be lower than those of potential cutaneous human exposure during Ostreopsis ovata blooms, indicating the harmful potential of the toxin...
  50. ncbi Human risk associated with palytoxin exposure
    Jonathan R Deeds
    US Food and Drug Administration Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, HFS 707, College Park, MD 20740, USA
    Toxicon 56:150-62. 2010
    ..Continued research into the distribution and occurrence of PTX and PTX-like compounds both in seafood and marine organisms sold in the aquarium trade appears warranted...
  51. pmc Palytoxin and analogs: biological and ecological effects
    Vitor Ramos
    Marine and Environmental Research Center CIIMAR CIMAR, Porto University, Rua dos Bragas, 289, 4050 123 Porto, Portugal
    Mar Drugs 8:2021-37. 2010
    ..In this paper, we review the current knowledge on the effects of PTX and its analogs on different organisms, exposing the impact that these toxins may have in coastal ecosystems...
  52. ncbi Case definitions for human poisonings postulated to palytoxins exposure
    A Tubaro
    Department of Materials and Natural Resources, University of Trieste, Via A Valerio 6, 34127 Trieste, Italy
    Toxicon 57:478-95. 2011
    ..A standardized protocol for data collection could provide a more rapid and reliable diagnosis of palytoxin-poisoning, but also the collection of necessary data for the risk assessment for this family of toxins...
  53. ncbi Retargeting polymer-coated adenovirus to the FGF receptor allows productive infection and mediates efficacy in a peritoneal model of human ovarian cancer
    Nicola K Green
    Hybrid Systems Ltd, Cherwell Innovation Centre, Upper Heyford, Oxfordshire OX25 5HD, UK
    J Gene Med 10:280-9. 2008
    ....
  54. ncbi Occurrence of palytoxin-group toxins in seafood and future strategies to complement the present state of the art
    Katerina Aligizaki
    Department of Botany, School of Biology, Aristotle University of Thessaloniki, PO Box 109, Thessaloniki 54124, Greece
    Toxicon 57:390-9. 2011
    ..Future recommendations include systematic screening of PlTX in those species and areas where PlTX has already been recorded implementing updated methodologies...
  55. ncbi Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery
    Yanxia Cao
    College of Pharmacy, China Pharmaceutical University, Nanjing, PR China
    J Control Release 120:186-94. 2007
    ..5-400 microg/ml. These results suggest that PNIPAAm-CS is a potential thermosensitive in situ gel-forming material for ocular drug delivery, and it may improve the bio-availability, efficacy, and compliance of some eye drugs...
  56. ncbi Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer
    Leonard W Seymour
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham, UK
    Int J Oncol 34:1629-36. 2009
    ....
  57. ncbi Palytoxins: biological and chemical determination
    Pilar Riobó
    Instituto de Investigaciones Marinas, CSIC, Eduardo Cabello, 6, CP36208 Vigo, Spain
    Toxicon 57:368-75. 2011
    ..This paper reviews all reported biological and chemical analysis methods to date for this group of compounds...
  58. ncbi LC-MS of palytoxin and its analogues: State of the art and future perspectives
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Toxicon 57:376-89. 2011
    ..In addition, lacking of certified reference standard of palytoxins as well as of validation studies for the proposed LC-MS methods represent important issues that should be faced for future perspectives of LC-MS technique...
  59. ncbi Influence of temperature and salinity on Ostreopsis cf. ovata growth and evaluation of toxin content through HR LC-MS and biological assays
    Laura Pezzolesi
    Centro Interdipartimentale di Ricerca per le Scienze Ambientali, Universita di Bologna, via S Alberto 163, 48123 Ravenna, Italy
    Water Res 46:82-92. 2012
    ....
  60. ncbi A review on the effects of environmental conditions on growth and toxin production of Ostreopsis ovata
    R Pistocchi
    Centro Interdipartimentale di Ricerca per le Scienze Ambientali, Universita di Bologna, via S Alberto 163, 48100 Ravenna, Italy
    Toxicon 57:421-8. 2011
    ..e. 40). For the same strain, both nitrogen and phosphorus limitation determined a decrease in cell toxicity showing different behaviour with respect to many other toxic dinoflagellates...
  61. ncbi The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels
    Bo Hjorth Bentzen
    The Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Medical Physiology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Neuropharmacology 51:1068-77. 2006
    ..In conclusion, (S)-1 differentially affects the Kv7 channel subtypes and is dependent on a single tryptophan for the current enhancing effect in Kv7.4...
  62. pmc Contribution of a membrane estrogen receptor to the estrogenic regulation of body temperature and energy homeostasis
    Troy A Roepke
    Department of Physiology and Pharmacology, Mail Code L334, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Endocrinology 151:4926-37. 2010
    ..Therefore, a Gq-mER-coupled signaling pathway appears to be involved in maintaining homeostatic functions and may constitute a novel therapeutic target for treatment of hypoestrogenic symptoms...
  63. ncbi Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin
    M S Iordanov
    Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Biol Chem 273:3528-34. 1998
    ..These results suggest that palytoxin-induced efflux of cellular K+ mimics ribotoxic stress by provoking both translational inhibition and activation of protein kinases associated with cellular defense against stress...
  64. ncbi The cytoskeleton, a structure that is susceptible to the toxic mechanism activated by palytoxins in human excitable cells
    M Carmen Louzao
    Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain
    FEBS J 274:1991-2004. 2007
    ..Palytoxin and ostreocin-D alter the ion fluxes, targeting pathways that involve the cytoskeletal dynamics of human excitable cells...
  65. pmc Palytoxin-induced effects on partial reactions of the Na,K-ATPase
    Nadine Harmel
    Department of Biology, University of Konstanz, Germany
    J Gen Physiol 128:103-18. 2006
    ..The previously suggested molecular model for the channel state of the Na,K-ATPase as a conformation in which both gates between binding sites and aqueous phases are simultaneously in their open state is supported by this study...
  66. ncbi Technology evaluation: PK1, Pfizer/Cancer Research UK
    Vladimir Bilim
    Department of Urology, Niigata University School of Medicine, Niigata University, Asahimachi 1, Niigata 951 8510, Japan
    Curr Opin Mol Ther 5:326-30. 2003
    ..PK1 is an N-(2-hydroxypropyl) methacrylamide (HPMA) co-polymer-doxorubicin conjugate, attached by a peptide linker, which is currently undergoing phase II trials for breast, non-small-cell lung and colon cancers...
  67. pmc Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering
    Kenichi Nagase
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, TWIns, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    J R Soc Interface 6:S293-309. 2009
    ....
  68. pmc A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin
    N E Schoemaker
    Department of Medical Oncology, Antoni van Leeuwenhoek Hospital The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Br J Cancer 87:608-14. 2002
    ..Haematological toxicity was relatively mild, but serious bladder toxicity was encountered which is typical for camptothecin and was found dose limiting...
  69. ncbi Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers
    Yong Jin Wu
    Bristol Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    J Med Chem 47:2887-96. 2004
    A new class of acrylamides was synthesized, and the effects of these analogues on outward potassium current were evaluated by using two electrode voltage clamp recordings from Xenopus laevis oocytes expressing cloned mKCNQ2 channels...
  70. pmc Degradation, cytotoxicity, and biocompatibility of NIPAAm-based thermosensitive, injectable, and bioresorbable polymer hydrogels
    Zhanwu Cui
    The School of Biological and Health Systems Engineering, Center for Interventional Biomaterials, Arizona State University, Tempe, Arizona 85287 9709, USA
    J Biomed Mater Res A 98:159-66. 2011
    ..2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011...
  71. ncbi Oxidative stress induced by palytoxin in human keratinocytes is mediated by a H+-dependent mitochondrial pathway
    Marco Pelin
    Department of Life Science, University of Trieste, via L Giorgieri 7 9, 34127 Trieste, Italy
    Toxicol Appl Pharmacol 266:1-8. 2013
    ....
  72. ncbi Ostreopsis cf. ovata bloom in the northern Adriatic Sea during summer 2009: ecology, molecular characterization and toxin profile
    Stefano Accoroni
    Dipartimento di Scienze del Mare, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Mar Pollut Bull 62:2512-9. 2011
    ..Toxin analysis performed by high resolution liquid chromatography-mass spectrometry revealed a high total toxin content (up to 75 pg cell(-1)), including putative palytoxin and all the ovatoxins known so far...
  73. ncbi A 4-decade-long (and still ongoing) hunt for palytoxins chemical architecture
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Toxicon 57:362-7. 2011
    ..Studies on the Mediterranean toxic outbreaks brought to light the existence of further palytoxin-like compounds, ovatoxins, never reported elsewhere in the world...
  74. ncbi Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells
    Gabriele Zoppoli
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Exp Hematol 38:979-88. 2010
    ..Here we have explored the interaction between APO866 and TRAIL in leukemia cell lines and in primary B-cell chronic lymphocytic leukemia cells...
  75. ncbi Palytoxin induces cell lysis by priming a two-step process in mcf-7 cells
    Simone Prandi
    Dipartimento di Scienze Biomediche, Università di Modena e Reggio Emilia, Via Campi 287, I 41125 Modena, Italy
    Chem Res Toxicol 24:1283-96. 2011
    ..A model of the two-step process of PlTX-induced cytolysis is presented...
  76. ncbi The cytotoxic pathway triggered by palytoxin involves a change in the cellular pool of stress response proteins
    Gian Luca Sala
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, via G Campi 287, I 41125 Modena, Italy, Italy
    Chem Res Toxicol 22:2009-16. 2009
    ....
  77. ncbi The pH-induced thermosensitive poly (NIPAAm-co-AAc-co-HEMA)-g-PCL micelles used as a drug carrier
    Weifeng Dai
    Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, P O Box 391, 130 Meilong Road, 200237 Shanghai, People s Republic of China
    J Mater Sci Mater Med 21:1881-90. 2010
    ..The release of DOX from micelles could be controlled by changing pH value and temperature in buffer solutions. The micelles are potentially to be used as a new anticancer drug carrier for intracellular delivery...
  78. ncbi Synthesis and antiviral bioactivities of 2-cyano-3-substituted-amino(phenyl) methylphosphonylacrylates (acrylamides) containing alkoxyethyl moieties
    Jia Qiang Yang
    Center for Research and Development of Fine Chemicals, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, People s Republic of China
    J Agric Food Chem 58:2730-5. 2010
    ..developed for the synthesis of a series of novel 2-cyano-3-substituted-amino(phenyl) methylphosphonylacrylates (acrylamides) II...
  79. ncbi Action of palytoxin on apical H+/K+-ATPase in rat colon
    Georgios Scheiner-Bobis
    Institute for Biochemistry and Endocrinology, Institute for Veterinary Physiology, Justus Liebig University Giessen, Germany
    Eur J Biochem 269:3905-11. 2002
    ..Consequently, the pore-forming action of palytoxin is not restricted to Na+/K+-ATPase but is also observed with the colonic H+/K+-ATPase...
  80. pmc Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin
    Aaron T Charlson
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Mayo Mail Code 807, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Toxicol Appl Pharmacol 241:143-53. 2009
    ..These results suggest that ERK5 can act as an alternative mediator for transmitting diverse tumor promoter-stimulated signals...
  81. ncbi Enhancement of transformed foci and induction of prostaglandins in Balb/c 3T3 cells by palytoxin: in vitro model reproduces carcinogenic responses in animal models regarding the inhibitory effect of indomethacin and reversal of indomethacin's effect by ex
    Daishiro Miura
    Pharmacology and Safety Research Department, Pharmaceutical Development Research Laboratories, Teijin Pharma Limited, 4 3 2, Asahigaoka, Hino, Tokyo 191 8512, Japan
    Toxicol Sci 89:154-63. 2006
    ..In the present study, palytoxin also induced prostaglandin synthesis, and therefore, the Balb/c 3T3 cell model should provide insight into the molecular mechanism by which palytoxin regulates prostaglandin biosynthesis...
  82. ncbi Health impact of unicellular algae of the Ostreopsis genus blooms in the Mediterranean Sea: experience of the French Mediterranean coast surveillance network from 2006 to 2009
    Lucia Tichadou
    Centre Antipoison, Hopital Salvator, Marseille, France
    Clin Toxicol (Phila) 48:839-44. 2010
    ....
  83. ncbi Harmful dinoflagellate Ostreopsis cf. ovata Fukuyo: detection of ovatoxins in field samples and cell immunolocalization using antipalytoxin antibodies
    Giorgio Honsell
    Agriculture and Environmental Sciences Department, University of Udine, Via delle Scienze 91 93, 33100 Udine, Italy
    Environ Sci Technol 45:7051-9. 2011
    ....
  84. ncbi Isolation and structure elucidation of ovatoxin-a, the major toxin produced by Ostreopsis ovata
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, University of Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Am Chem Soc 134:1869-75. 2012
    ..Elucidation of ovatoxin-a's complex structure will ultimately herald the understanding of the molecular bases of ovatoxins bioactivity...
  85. ncbi Cytotoxic effect of palytoxin on mussel
    M Carmen Louzao
    Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain
    Toxicon 56:842-7. 2010
    ..These findings have a special significance for the marine environment and aquiculture since they are evidence for the ability of palytoxin to affect the integrity of bivalve mollusks that are not adapted to the presence of this toxin...
  86. ncbi High resolution LC-MS(n) fragmentation pattern of palytoxin as template to gain new insights into ovatoxin-a structure. The key role of calcium in MS behavior of palytoxins
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Am Soc Mass Spectrom 23:952-63. 2012
    ..Either the regions or the specific sites where ovatoxin-a and palytoxin structurally differ have been identified...
  87. ncbi Palytoxin in seafood by liquid chromatography tandem mass spectrometry: investigation of extraction efficiency and matrix effect
    Patrizia Ciminiello
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Anal Bioanal Chem 401:1043-50. 2011
    ....
  88. pmc Injectable pH- and temperature-responsive poly(N-isopropylacrylamide-co-propylacrylic acid) copolymers for delivery of angiogenic growth factors
    Jessica C Garbern
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Biomacromolecules 11:1833-9. 2010
    ..This hydrogel system will thus gel at controllable acidic pH values upon injection, and is designed to undergo gradual dissolution as it performs its drug delivery function and the ischemic site returns to physiological pH...
  89. ncbi Antinociceptive pharmacology of N-[[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6-dimethylphenyl) sulfonyl]methylamino]ethoxy]-N-methylacetamide, fumarate (LF22-0542), a novel nonpeptidic bradykinin B1 receptor antagonist
    F Porreca
    Department of Pharmacology, University of Arizona, Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Pharmacol Exp Ther 318:195-205. 2006
    ....
  90. pmc Gene expression profile of the cartilage tissue spontaneously regenerated in vivo by using a novel double-network gel: comparisons with the normal articular cartilage
    Ryusei Imabuchi
    Department of Sports Medicine and Joint Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    BMC Musculoskelet Disord 12:213. 2011
    ..The purpose of this study was to clarify gene expression profile of the regenerated tissue in comparison with that of the normal articular cartilage...
  91. ncbi Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells
    Begoña Espiña
    Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, 27002 Lugo, Spain
    Biosci Rep 29:13-23. 2009
    ....
  92. ncbi Structure elucidation of ostreocin D, a palytoxin analog isolated from the dinoflagellate Ostreopsis siamensis
    T Ukena
    Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 65:2585-8. 2001
    ..Partial stereochemical assignments were done. This result indicates that the dinoflagellate O. siamensis is one of the biogenetic origins of palytoxin...
  93. ncbi Substituted acrylamides as factor Xa inhibitors: improving bioavailability by P1 modification
    Yonghong Song
    Millennium Pharmaceuticals, Inc, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 12:2043-6. 2002
    ..Modification of P4 moiety of these compounds further improved their pharmacokinetic properties...
  94. ncbi Diversity of marine biotoxins in the near-shore ocean area: presence of a palytoxin-like entity at Barber's Point Harbor, Oahu
    K M Wachi
    Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822, USA
    J Nat Toxins 10:317-33. 2001
    ..Moderate correlation (R2) between mouse toxicity and sheep erythrocyte hemolysis was shown with 50 microg (R2 = 0.48) and 100 microg (R2 = 0.45) extracts. An inverse correlation of R2 = 0.64 was shown between hemolysis and MIA endpoint...
  95. ncbi Cell growth and detachment from protein-coated PNIPAAm-based copolymers
    Martin T Moran
    National Centre for Biomedical Engineering Sciences, National University of Ireland, Galway, Ireland
    J Biomed Mater Res A 81:870-6. 2007
    ..The results demonstrate a versatile method for the cultivation of cells while eliminating the need for the use of digestive enzymes such as trypsin...
  96. ncbi Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography
    Matthias M Herth
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Biomacromolecules 10:1697-703. 2009
    ..Furthermore, low metabolism rates could be detected in urine as well as in the blood. Thus, we expect this new strategy for radioactive labeling of polymers as a promising approach for in vivo PET studies...
  97. ncbi Automated method for measuring globin adducts of acrylamide and glycidamide at optimized Edman reaction conditions
    Hubert W Vesper
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE MS F 25, USA
    Rapid Commun Mass Spectrom 20:959-64. 2006
    ..The GA-Hb/AA-Hb ratio decreases significantly with increasing AA-Hb values indicating that measurement of AA-Hb as well as GA-Hb are needed to appropriately assess human exposure to acrylamide...
  98. ncbi Toxicological effects of marine palytoxin evaluated by FETAX assay
    Antonella Franchini
    Department of Animal Biology, University of Modena and Reggio Emilia, Via Campi 213 D, 41100 Modena, Italy
    Chemosphere 73:267-71. 2008
    ..No inflammatory response was observed...
  99. ncbi Synthesis and biological evaluation of isosteric analogues of FK866, an inhibitor of NAD salvage
    Ubaldina Galli
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center Università degli Studi del Piemonte Orientale A Avogadro, Via Bovio 6, 28100 Novara, Italy
    ChemMedChem 3:771-9. 2008
    ..Here we report the synthesis of analogues of FK866 synthesized by click chemistry...
  100. ncbi Anticancer agent CHS-828 inhibits cellular synthesis of NAD
    Uffe Høgh Olesen
    Experimental Pathology Unit, National University Hospital, Biocentre, Building 2, 3rd Floor, Ole Maaloes Vej 5, 2200 Copenhagen, Denmark
    Biochem Biophys Res Commun 367:799-804. 2008
    ..Finally, we observed that treatment with CHS-828 depletes cellular NAD levels in sensitive cancer cells. In conclusion, these results strongly suggest that, like FK866, CHS-828 kills cancer cells by depleting NAD...
  101. ncbi Effects of the marine toxins okadaic acid and palytoxin on mussel phagocytosis
    Davide Malagoli
    Department of Animal Biology, University of Modena and Reggio Emilia, Via Campi 213 D, Modena, Italy
    Fish Shellfish Immunol 24:180-6. 2008
    ..Overall, we conclude that both OA and PTX influence mussel phagocytic activity, and the toxic effects may depend on both the mollusc conditions and the activation of specific signalling pathways...

Research Grants25

  1. CYTOSKELETAL TARGETS OF NEURONAL/TESTICULAR TOXICANTS
    Kim Boekelheide; Fiscal Year: 1993
    A group of large volume, commercially important environmental and industrial toxicants - including the acrylamides, organophosphorus esters and the hexacarbons - selectively injure the nervous system and male reproductive system...
  2. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  3. Negative Regulators: Key Determinants in Carcinogenesis
    ELIZABETH WATTENBERG; Fiscal Year: 2009
    ....
  4. Ca2+ channels in non-excitable cells
    William Schilling; Fiscal Year: 2006
    ..abstract_text> ..
  5. Bcr-Abl thiophosphorylation profiling in CML using MALDI
    Laurie Parker; Fiscal Year: 2006
    ..apos; ..
  6. Polymers with time-dependent properties for drug deliver
    Brent Vernon; Fiscal Year: 2007
    ..In vivo compatibility will be assessed using selected histological techniques. In vivo efficacy of phenstatin released from this material will be evaluated using a SCID mouse ovarian cancer model. ..
  7. Function and regulation of cardiac Na transporters
    Donald Hilgemann; Fiscal Year: 2008
    ..4) In parallel with the experimental program, we will develop improved mathematical models of cardiac ion homeostasis with an emphasis on these three Na transporters. ..
  8. HEART-LUNG PHYSIOLOGY: MOLECULAR-SYSTEMIC INTEGRATION
    William Schilling; Fiscal Year: 2008
    ..Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, continues to develop well-rounded scientists trained in integrated aspects of cardio-respiratory physiology. ..
  9. A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPY
    JINDRICH H KOPECEK; Fiscal Year: 2010
    ..The concept of double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drugs for the treatment of ovarian cancer. ..
  10. Targeted Proapoptotic Anticancer Drug Delivery Systems
    Tamara Minko; Fiscal Year: 2010
    ..abstract_text> ..
  11. BIFUNCTIONAL OPIOID/CCK LIGANDS FOR PAIN
    Frank Porreca; Fiscal Year: 2006
    ..This novel mechanism of action should yield therapeutic utility as well as provide an increased understanding of opioid-CCK interactions in normal and pathological pain states. ..
  12. Regulation of PMCA Pump-Channels by Oxidant Stress
    William P Schilling; Fiscal Year: 2010
    ..abstract_text> ..
  13. STRUCTURES OF ACETYLCHOLINE RECEPTORS
    Arthur Karlin; Fiscal Year: 2003
    ..The Cys will be substituted for residues known to contribute to the binding of ACh. ..
  14. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2003
    ..Based on in vivo animal data criteria will be studied. Based on in vivo animal data criteria will be established for the design of an oral hCT and CKI delivery system for the treatment of postmenopausal osteoporosis. ..
  15. Enteric Nervous System 2003
    Keith Sharkey; Fiscal Year: 2003
    ..From this picture there will be gaps - these are the challenges for the future. ..
  16. TARGETING TO LYMPHOCYTES MEDIATED BY SYNTHETIC EPITOPES
    Jindrich Kopecek; Fiscal Year: 2004
    ..The results of the proposed studies will provide a new method to treat human lymphomas. ..
  17. The malignant stem cell in multiple myeloma
    Linda Pilarski; Fiscal Year: 2004
    ..This may lead to improvements in therapy and survival for myeloma patients. ..
  18. LC-MS/MS Methods for Analysis of Hemoglogbin Adducts
    Timothy Fennell; Fiscal Year: 2004
    ..abstract_text> ..
  19. Role of Ion Channels in Cell Death
    William Schilling; Fiscal Year: 2005
    ..abstract_text> ..
  20. HYBRID HYDROGELS SELF-ASSEMBLED FROM GRAFT COPOLYMERS
    Jindrich Kopecek; Fiscal Year: 2008
    ..In addition, the possibility to join non-compatible materials, such as hydrophobic muscle mimics from liquid crystalline polymers and hydrogels, may open a new field of research. ..
  21. Molecular Targeting of Drug Delivery System to Cancer
    Tamara Minko; Fiscal Year: 2010
    ..This will permit us to increase the efficacyof cancer chemotherapy by simultaneous suppression of pump and nonpump resistance. ..
  22. DEGRADABLE HYDROGELS FOR ORAL DELIVERY OF CALCITONIN
    Jindrich Kopecek; Fiscal Year: 2001
    ..Based on in vivo animal data criteria will be studied. Based on in vivo animal data criteria will be established for the design of an oral hCT and CKI delivery system for the treatment of postmenopausal osteoporosis. ..
  23. Brainstem Mechanisms of Craniofacial Muscle Pain
    JIN RO; Fiscal Year: 2006
    ..abstract_text> ..
  24. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  25. VOLTAGE-CLAMP STUDIES OF SODIUM PUMP CURRENT AND FLUX
    ROBERT RAKOWSKI; Fiscal Year: 2007
    ..Mutations that fail to pump will be tested to determine if they are sensitive to palytoxin and hence present in the surface membrane. ..