pyruvaldehyde

Summary

Summary: An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.

Top Publications

  1. ncbi Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal
    Ram H Nagaraj
    Center for Vision Research, Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Wearn Building, Room 643, Cleveland, OH 44106, USA
    Arch Biochem Biophys 402:110-9. 2002
  2. pmc Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies
    Mirjam J Eberhardt
    Institute of Physiology and Pathophysiology Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 287:28291-306. 2012
  3. pmc Hyperglycemia impairs proteasome function by methylglyoxal
    Markus A Queisser
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    Diabetes 59:670-8. 2010
  4. pmc Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
    P J Thornalley
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester CO43SQ, Essex, U K
    Biochem J 344:109-16. 1999
  5. pmc Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease
    Paul J Thornalley
    Protein Damage and Systems Biology Research Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
    Drug Metabol Drug Interact 23:125-50. 2008
  6. ncbi Stimulation of suicidal erythrocyte death by methylglyoxal
    Jan P Nicolay
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 18:223-32. 2006
  7. pmc Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    O Brouwers
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 53:989-1000. 2010
  8. ncbi The tandem of free radicals and methylglyoxal
    Miklos Peter Kalapos
    Theoretical Biology Research Group, Budapest, Hungary
    Chem Biol Interact 171:251-71. 2008
  9. ncbi Methylglyoxal production in bacteria: suicide or survival?
    G P Ferguson
    Department of Molecular and Cell Biology, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, Scotland AB25 2ZD
    Arch Microbiol 170:209-18. 1998
  10. ncbi Oxidative stress and aging: is methylglyoxal the hidden enemy?
    Kaushik M Desai
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Can J Physiol Pharmacol 88:273-84. 2010

Research Grants

  1. DNA MODIFICATIONS BY PYRUVALDEHYDE
    Ching Jer Chang; Fiscal Year: 1993
  2. Glycation and mu dicarbonyls in diabetic complications
    Paul Beisswenger; Fiscal Year: 2006
  3. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2005
  4. Novel Pathways of AGE Formation in Diabetes
    RAM NAGARAJ; Fiscal Year: 2005
  5. Modifications of Small Heat Shock Proteins in the Lens
    RAM NAGARAJ; Fiscal Year: 2009
  6. Oxidative Stress, VEGF and Retinopathy
    DAVID VANDER JAGT; Fiscal Year: 2004
  7. Alzheimer's Disease Drugs
    DAVID VANDER JAGT; Fiscal Year: 2008
  8. Acylation as an Approach to Enhance the Cancer Preventive Effect of EGCG
    Shengmin Sang; Fiscal Year: 2007
  9. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
  10. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002

Detail Information

Publications236 found, 100 shown here

  1. ncbi Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal
    Ram H Nagaraj
    Center for Vision Research, Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Wearn Building, Room 643, Cleveland, OH 44106, USA
    Arch Biochem Biophys 402:110-9. 2002
    ..Our studies show that pyridoxamine reduces oxidative stress and AGE formation. We suspect that a direct interaction of pyridoxamine with MG partly accounts for AGE inhibition...
  2. pmc Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies
    Mirjam J Eberhardt
    Institute of Physiology and Pathophysiology Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 287:28291-306. 2012
    ..In conclusion, MG is proposed to be a candidate metabolite that causes neuropathic pain in metabolic disorders and thus is a promising target for medicinal chemistry...
  3. pmc Hyperglycemia impairs proteasome function by methylglyoxal
    Markus A Queisser
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    Diabetes 59:670-8. 2010
    ..In this study, the influence of MGO-derived advanced glycation end product (AGE) formation on the activity of the proteasome was investigated in vitro and in vivo...
  4. pmc Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
    P J Thornalley
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester CO43SQ, Essex, U K
    Biochem J 344:109-16. 1999
    ..Short periods of hyperglycaemia, as occur in impaired glucose tolerance, may be sufficient to increase the concentrations of alpha-oxoaldehydes in vivo...
  5. pmc Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease
    Paul J Thornalley
    Protein Damage and Systems Biology Research Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
    Drug Metabol Drug Interact 23:125-50. 2008
    ..Latest research suggests there are functional modifications of this process--implying a role in cell signalling, ageing and disease...
  6. ncbi Stimulation of suicidal erythrocyte death by methylglyoxal
    Jan P Nicolay
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 18:223-32. 2006
    ..In conclusion, methylglyoxal impairs energy production and anti-oxidative defense, effects contributing to the enhanced PS exposure of circulating erythrocytes and eventually resulting in anemia and deranged microcirculation...
  7. pmc Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    O Brouwers
    Department of Internal Medicine, University Hospital Maastricht, P Debyelaan 25, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 53:989-1000. 2010
    ..We investigated the effect of hyperglycaemia on impaired vasoreactivity and a putative role therein of the AGE precursor methylglyoxal...
  8. ncbi The tandem of free radicals and methylglyoxal
    Miklos Peter Kalapos
    Theoretical Biology Research Group, Budapest, Hungary
    Chem Biol Interact 171:251-71. 2008
    ..Both oxidative and nitrosative stress play important but not indispensable role in the development of methylglyoxal toxicity...
  9. ncbi Methylglyoxal production in bacteria: suicide or survival?
    G P Ferguson
    Department of Molecular and Cell Biology, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, Scotland AB25 2ZD
    Arch Microbiol 170:209-18. 1998
    ..New strategies for antibacterial therapy may be based on undermining the detoxification and defence mechanisms coupled with deregulation of methylglyoxal synthesis...
  10. ncbi Oxidative stress and aging: is methylglyoxal the hidden enemy?
    Kaushik M Desai
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Can J Physiol Pharmacol 88:273-84. 2010
    ..Specific and effective scavengers and crosslink breakers of MG and AGEs are being developed and can become potential treatments to slow the aging process and prevent many diseases...
  11. ncbi Glyoxal and methylglyoxal levels in diabetic patients: quantitative determination by a new GC/MS method
    Annunziata Lapolla
    Dipartimento di Scienze Mediche e Chirurgiche, Universita di Padova, Padova, Italy
    Clin Chem Lab Med 41:1166-73. 2003
    ..However, a similar behavior of pentosidine indicates that these alternative pathways can be only partially responsible for glyoxal and methylglyoxal production...
  12. ncbi Methylglyoxal is a predictor in type 2 diabetic patients of intima-media thickening and elevation of blood pressure
    Susumu Ogawa
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Hypertension 56:471-6. 2010
    ..DG is an independent risk factor for the percentage change of ACR. MG is a predictor in type 2 diabetic patients of intima-media thickening, of increase of PWV, and of elevation of SBP...
  13. ncbi Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells
    Tuanjie Chang
    Department of Pharmacology, College of Medicine, and The Cardiovascular Research Group, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    Free Radic Biol Med 38:286-93. 2005
    ..An elevated MG level and the consequential ROS/RNS generation would alter cellular signaling pathways, contributing to the development of different insulin resistance states such as diabetes or hypertension...
  14. ncbi Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway
    R Kimura
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Neuroscience 162:1212-9. 2009
    ..The GLP-1-induced redox restoration was also attenuated by rapamycin. In conclusion, the neuroprotective effect of GLP-1 is due to an enhancement of PI3K/Akt/mTOR/GCLc/redox signaling...
  15. pmc Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA
    N Murata-Kamiya
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
    Nucleic Acids Res 29:3433-8. 2001
    ....
  16. ncbi Dicarbonyl intermediates in the maillard reaction
    Paul J Thornalley
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
    Ann N Y Acad Sci 1043:111-7. 2005
    ..Along with fructosamine formation, alpha-oxoaldehyde intermediates of the Maillard reaction represent a major source of damage to the proteome and genome...
  17. pmc Chronic methylglyoxal infusion by minipump causes pancreatic beta-cell dysfunction and induces type 2 diabetes in Sprague-Dawley rats
    Arti Dhar
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Diabetes 60:899-908. 2011
    ..MG levels are elevated in diabetic patients. We investigated the effects of chronic administration of MG on glucose tolerance and β-cell insulin secreting mechanism in 12-week-old male Sprague-Dawley rats...
  18. ncbi Advanced glycation end products as biomarkers and gerontotoxins - A basis to explore methylglyoxal-lowering agents for Alzheimer's disease?
    Martina Krautwald
    Department of Pharmacology, University of Western Sydney, Campbelltown, Australia
    Exp Gerontol 45:744-51. 2010
    ..Alternatively, methylglyoxal could be scavenged by various types of carbonyl scavengers...
  19. pmc The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli
    Ertan Ozyamak
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Mol Microbiol 78:1577-90. 2010
    ..The data are discussed in terms of how cell fate is determined by the relative abundance of the enzymes and KefGB...
  20. ncbi Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy
    Jianxin Lu
    Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine, Wenzhou Medical College, Wenzhou, China
    Clin Biochem 44:307-11. 2011
    ..To investigate the association of plasma levels of methylglyoxal (MG) and markers of inflammation/endothelial dysfunction with diabetic nephropathy (DN)...
  21. ncbi Genistein protects methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells
    Hsin Jung Wu
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, 200, Chung Pei Road, Chung Li 32023, Taiwan, ROC
    Toxicol In Vitro 21:335-42. 2007
    ..These results collectively suggest that oxidative stress plays a role in MG-induced cell injury, and that genistein blocks these effects by virtue of its antioxidant properties, consequently preventing cell apoptosis...
  22. pmc Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2
    Hongtao Liu
    Section of Endocrinology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
    PLoS ONE 7:e46720. 2012
    ..Taken together, MGO reduces endothelial angiogenesis through RAGE-mediated, ONOO(-)dependent and autophagy-induced VEGFR2 degradation, which may represent a new mechanism for diabetic angiogenesis impairment...
  23. ncbi Methylglyoxal in food and living organisms
    Ina Nemet
    Department of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, Zagreb, Croatia
    Mol Nutr Food Res 50:1105-17. 2006
    ..The methods include three basic steps: deproteinization, incubation with derivatization agent, and chromatographic analysis with or without preliminary extraction of the formed products...
  24. ncbi Fructose-induced peroxynitrite production is mediated by methylglyoxal in vascular smooth muscle cells
    Hui Wang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    Life Sci 79:2448-54. 2006
    ..Our results demonstrated that fructose is capable of inducing a significant increase in ONOO(-) production, which is mediated by an enhanced formation of endogenous MG in VSMCs...
  25. pmc Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal
    Margaret G Distler
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 122:2306-15. 2012
    ..Finally, we demonstrated that pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders...
  26. ncbi Isolation by HPLC and characterisation of the bioactive fraction of New Zealand manuka (Leptospermum scoparium) honey
    Christopher J Adams
    Chemistry Department, University of Waikato, Private Bag 3105, Hamilton, New Zealand
    Carbohydr Res 343:651-9. 2008
    ..Concentrations obtained using both the methods were similar and varied from 38 to 828 mg/kg...
  27. ncbi Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation
    Mingzhan Xue
    Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK
    Biochem J 443:213-22. 2012
    ..We conclude that dicarbonyl stress is countered by up-regulation of Glo1 in the Nrf2 stress-responsive system, protecting protein and DNA from increased damage and preserving cell function...
  28. ncbi Radical generation by the non-enzymatic reaction of methylglyoxal and hydrogen peroxide
    Masaaki Nakayama
    Tohoku University Graduate School of Medicine, Research Division of Dialysis and Chronic Kidney Disease, Sendai, Japan
    Redox Rep 12:125-33. 2007
    ..However, the exact mechanism by which these molecules induce oxidative stress is unclear. We hypothesized that intermediate compounds, such as free radicals, are generated during the chemical reaction between H(2)O(2) and MG or GO...
  29. pmc Evidence of high levels of methylglyoxal in cultured Chinese hamster ovary cells
    F W Chaplen
    Department of Chemical Engineering, 1415 Engineering Drive, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 95:5533-8. 1998
    ..Thus, 5-10% of cellular proteins may be modified to physiologically significant levels...
  30. ncbi Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity
    Naila Ahmed
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    J Biol Chem 280:5724-32. 2005
    ..Methylglyoxal modification of critical arginine residues, therefore, whether experimental or physiological, is expected to disrupt protein-ligand interactions and inactivate enzyme activity by hydroimidazolone formation...
  31. ncbi The glyoxalase pathway: the first hundred years... and beyond
    Marta Sousa Silva
    Centro de Quimica e Bioquimica, Departamento de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, Portugal
    Biochem J 453:1-15. 2013
    ....
  32. pmc Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging
    Jaime Uribarri
    Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Gerontol A Biol Sci Med Sci 62:427-33. 2007
    ..AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons...
  33. pmc Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress
    Naila Rabbani
    Protein Damage and Systems Biology Research Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK
    Biochem Soc Trans 36:1045-50. 2008
    ..Future research will address the functional charges in mitochondrial proteins that are the targets for dicarbonyl glycation...
  34. ncbi Protective mechanisms against toxic electrophiles in Escherischia coli
    G P Ferguson
    Dept of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK AB25 2ZD
    Trends Microbiol 7:242-7. 1999
    ..In the absence of one of these mechanisms, electrophiles induce rapid killing. Hence it appears that electrophile-protective mechanisms represent novel targets for antibacterial drug research...
  35. pmc A comparative study of methylglyoxal metabolism in trypanosomatids
    Neil Greig
    Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, UK
    FEBS J 276:376-86. 2009
    ..We propose that the predominant mechanism for methylglyoxal detoxification in the African trypanosome is via the methylglyoxal reductase pathway to l-lactate...
  36. ncbi From famine to feast: the role of methylglyoxal production in Escherichia coli
    S Tötemeyer
    Department of Molecular and Cell Biology, Institute of Medical Sciences, University of Aberdeen, UK
    Mol Microbiol 27:553-62. 1998
    ..A mutant lacking MGS was constructed, and it grew normally on a range of carbon sources and on low-phosphate medium. However, the mutant failed to produce MG during growth on xylose in the presence of cAMP, and growth was inhibited...
  37. ncbi Methylglyoxal, oxidative stress, and hypertension
    Tuanjie Chang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada
    Can J Physiol Pharmacol 84:1229-38. 2006
    ..It is proposed that elevated methylglyoxal level and resulting protein glycation and ROS production may be the upstream links in the chain reaction leading to the development of hypertension...
  38. ncbi Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons
    Silvia Di Loreto
    Institute for Organ Transplantation and Immunocytology ITOI, CNR, P le Collemaggio, 67100 L Aquila, Italy
    Int J Biochem Cell Biol 40:245-57. 2008
    ..This, in turn, triggers widespread apoptotic cell death, occurring through the convergence of both mitochondrial and Fas-receptor pathways...
  39. ncbi Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress
    Paul J Beisswenger
    Department of Medicine, Diabetes, Endocrinology and Metabolism, Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Diabetes 54:3274-81. 2005
    ....
  40. ncbi Advanced glycation end-products (AGEs): involvement in aging and in neurodegenerative diseases
    M A Grillo
    Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universita di Torino, Torino, Italy
    Amino Acids 35:29-36. 2008
    ..Compounds able to inhibit AGEs formation are also taken into consideration...
  41. pmc Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose
    Arti Dhar
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Br J Pharmacol 161:1843-56. 2010
    ..We investigated if MG induces endothelial dysfunction and whether MG scavengers can prevent endothelial dysfunction induced by MG and high glucose concentrations...
  42. pmc Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats
    Olaf Brouwers
    Department of Internal Medicine, Division of General Internal Medicine, Laboratory for Metabolism and Vascular Medicine, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands
    J Biol Chem 286:1374-80. 2011
    ..The reduction of oxidative stress by GLO-I overexpression directly demonstrates the link between glycation and oxidative stress...
  43. ncbi Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol-dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR-family regulator YraB (AdhR)
    Thi Thu Huyen Nguyen
    Institute for Microbiology, Ernst Moritz Arndt University of Greifswald, D 17487 Greifswald, Germany
    Mol Microbiol 71:876-94. 2009
    ..We speculate that AdhR is redox-regulated via thiol-(S)-alkylation by aldehydes and that AdhA and YraA are specifically involved in reduction of aldehydes and degradation or repair of damaged thiol-containing proteins respectively...
  44. ncbi Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand
    Elvira Mavric
    Institute of Food Chemistry, Technische Universitat Dresden, Dresden, Germany
    Mol Nutr Food Res 52:483-9. 2008
    ..1-1.8 mM. This clearly demonstrates that the pronounced antibacterial activity of New Zealand Manuka honey directly originates from MGO...
  45. ncbi Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases
    S Kikuchi
    Department of Neurology, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan
    J Neurosci Res 57:280-9. 1999
    ....
  46. ncbi Metformin reduces systemic methylglyoxal levels in type 2 diabetes
    P J Beisswenger
    Department of Medicine, Dartmouth Hitchcock Medical Center and Dartmouth Medical School, Lebanon, New Hampshire 03756, USA
    Diabetes 48:198-202. 1999
    ..To the extent that elevated MG levels lead to their development, metformin treatment may protect against diabetic complications by mechanisms independent of its antihyperglycemic effect...
  47. ncbi Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process
    J Du
    Department of Immunology, Nagoya University School of Medicine, Aichi, Japan
    Free Radic Biol Med 31:469-78. 2001
    ..These results suggest that activating ASK1 at the early stage linking to production of O(2)(-) is crucial for subsequent progression of apoptosis in MG-treated Jurkat cells...
  48. ncbi Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis
    Nicole Verzijl
    TNO Prevention and Health, Leiden, The Netherlands
    Arthritis Rheum 46:114-23. 2002
    ..We studied the effect of AGE crosslinking on the stiffness of the collagen network in human articular cartilage...
  49. ncbi Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats
    Xiaoxia Wang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Hypertens 26:765-72. 2008
    ..The purpose of this study was to investigate whether increased endogenous formation of methylglyoxal and methylglyoxal-induced AGEs caused hypertension development in normotensive Sprague Dawley rats...
  50. ncbi Bacterial production of methylglyoxal: a survival strategy or death by misadventure?
    I R Booth
    Department of Molecular and Cell Biology, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, U K
    Biochem Soc Trans 31:1406-8. 2003
    ..Excessive production of MG is an adaptive ploy, which, if it fails, has fatal consequences. On this basis one might define MG-induced loss of life as "death by misadventure" rather than suicide!..
  51. ncbi AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation
    Thomas Gawlowski
    Heart and Diabetes Center NRW, Ruhr University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany
    Thromb Res 121:117-26. 2007
    ..The aim of this study was to investigate the impact of AGE-BSA, the model substance for AGEs, and MG on cellular haemostasis...
  52. ncbi Radiolabeling rhesus monkey CD34+ hematopoietic and mesenchymal stem cells with 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) for microPET imaging
    Joanne Huang
    Center of Excellence in Translational Human Stem Cell Research, Department of Biomedical Engineering, College of Engineering, School of Medicine, University of California, Davis, CA 95616 8542, USA
    Mol Imaging 7:1-11. 2008
    ..The goal of this study was to assess the potential toxicity of 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (PTSM) on rhesus monkey CD34+ hematopoietic and mesenchymal stem cells in ..
  53. ncbi Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome
    Jianghai Liu
    Department of Pharmacology, College of Medicine, University of Saskatchewan, A120 Health Sciences Building, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    Cardiovasc Res 92:494-503. 2011
    ..Methylglyoxal (MG) overproduction has been reported in metabolic syndrome with hyperglycaemia (diabetes) or without hyperglycaemia (hypertension), and the underlying mechanism was investigated...
  54. ncbi Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?
    T Fleming
    Department of Medicine and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Diabetologia 55:1151-5. 2012
    ....
  55. ncbi Hsp31 of Escherichia coli K-12 is glyoxalase III
    Krishna P Subedi
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 335 Gwahangno, Yuseong Gu, Daejon 305 701, Korea
    Mol Microbiol 81:926-36. 2011
    ..Furthermore, an accumulation of intracellular MG was observed in hchA-deficient strains...
  56. ncbi Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E
    F Fiory
    Dipartimento di Biologia e Patologia Cellulare e Molecolare and Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita degli Studi di Napoli Federico II, Naples, Italy
    Diabetologia 54:2941-52. 2011
    ..Here we investigated the ability of MGO to interfere with insulin signalling and to affect beta cell functions in the INS-1E beta cell line...
  57. pmc Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells
    De Shou Cao
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
    PLoS ONE 7:e38005. 2012
    ..TRPA1 is an attractive candidate for inducing insulin release because it is calcium permeable and is activated by molecules that are produced during oxidative glycolysis...
  58. ncbi Humoral methylglyoxal level reflects glycemic fluctuation
    Ina Nemet
    Department of Organic Chemistry and Biochemistry, Ruder Boskovic Institute, HR 10 002 Zagreb, Croatia
    Clin Biochem 38:379-83. 2005
    ..The aim of this study was to examine the hypothesis that methylglyoxal overproduction is affected by glycemic fluctuation...
  59. ncbi Elevated level of methylglyoxal during diabetic ketoacidosis and its recovery phase
    Z Turk
    Vuk Vrhovac, University Clinic for Diabetes, Zagreb, Croatia
    Diabetes Metab 32:176-80. 2006
    ..Excessive production of toxic intermediates such are alpha-dicarbonyls may be a link connecting an acute metabolic event with accelerated tissue damage, a feature characteristic of long-term complications of diabetes...
  60. ncbi Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells
    Bing Fen Liu
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kidney Int 63:947-57. 2003
    ..We therefore examined whether MG was capable of inducing apoptosis in rat mesangial cells to address the possible mechanism by which hyperglycemia-related products accelerated pathologic changes in diabetic glomerulosclerosis...
  61. ncbi Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes
    B K Kilhovd
    Aker Diabetes Research Centre and the Hormone Laboratory, Aker University Hospital, Oslo, Norway
    Metabolism 52:163-7. 2003
    ..The observed differences between patients with diabetes and nondiabetic controls seem to be comparable to differences measured for other AGE compounds...
  62. ncbi Methylglyoxal enhances sodium nitroprusside-induced relaxation in rat aorta
    Masashi Mukohda
    Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Japan
    J Pharmacol Sci 112:176-83. 2010
    ..The present study revealed that MGO enhanced SNP-induced relaxation in a ROS-independent manner via in part opening smooth muscle BK(Ca) channels...
  63. ncbi Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells
    Lingyun Wu
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Hypertension 39:809-14. 2002
    ..Our findings suggest that that elevated methylglyoxal and associated oxidative stress possibly contribute to the pathogenesis of hypertension...
  64. pmc Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats
    Xianguang Chen
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Hypertens Res 36:361-7. 2013
    ..These results suggest that MG-induced hypertension and cardio-renal injury and increased inflammation and carbonyl and oxidative stress, which were partially preventable by an ARB...
  65. ncbi Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes
    Yingchun Han
    Department of Laboratory Medicine, Memorial University, St John s, Canada
    Mol Cell Biochem 305:123-31. 2007
    ..In complication-free patients, increased plasma methylglyoxal, plasma glyoxal, and erythrocyte Na+/K+ ATPase activity may foretell future diabetic complications, and emphasize a need for aggressive management...
  66. ncbi Glycotoxines, carbonyl stress and relevance to diabetes and its complications
    Z Turk
    Vuk Vrhovac University Clinic for Diabetes, Zagreb, Croatia
    Physiol Res 59:147-56. 2010
    ..Their role in the advanced glycation process and detrimental effects on vascular tissue are discussed...
  67. ncbi Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats
    Qi Guo
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    J Hypertens 27:1664-71. 2009
    ..The present study was designed to investigate whether methylglyoxal could directly induce insulin resistance and salt sensitivity in Sprague-Dawley rats...
  68. ncbi Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction
    C F Bento
    Center of Ophthalmology and Vision Sciences COCV IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Exp Physiol 95:955-70. 2010
    ....
  69. pmc Genetic engineering of the glyoxalase pathway in tobacco leads to enhanced salinity tolerance
    S L Singla-Pareek
    Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India
    Proc Natl Acad Sci U S A 100:14672-7. 2003
    ..These findings establish the potential of manipulation of the glyoxalase pathway for increased salinity tolerance without affecting yield in crop plants...
  70. ncbi Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal
    Y Naito
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    J Physiol Pharmacol 60:123-30. 2009
    ....
  71. ncbi How honey kills bacteria
    Paulus H S Kwakman
    Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    FASEB J 24:2576-82. 2010
    ..3 to 7.0 reduced the activity to that of sugar alone. Activity against all other bacteria tested depended on sugar, H(2)O(2), MGO, and bee defensin-1. Thus, we fully characterized the antibacterial activity of medical-grade honey...
  72. ncbi Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species
    Audrey Riboulet-Chavey
    INSERM U145, IFR50, Faculty of Medicine, 06107 Nice Cedex 2, France
    Diabetes 55:1289-99. 2006
    ..By such a mechanism, methylglyoxal may not only induce the debilitating complications of diabetes but may also contribute to the pathophysiology of diabetes in general...
  73. ncbi Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions
    P J Thornalley
    Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, United Kingdom
    Biochem Pharmacol 60:55-65. 2000
    ..This effect is limited, however, by the rapid renal elimination of AG. Decreased AGE formation is implicated in the prevention of microvascular complications of diabetes by AG...
  74. ncbi The pro-oxidant role of methylglyoxal in mesenteric artery smooth muscle cells
    Lingyun Wu
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Can J Physiol Pharmacol 83:63-8. 2005
    ..In summary, MG significantly increases oxidative stress and activates NF-kappaB p65 in mesenteric artery SMCs. The pro-oxidant role of methylglyoxal may contribute to various pathological changes of SMCs from resistance arteries...
  75. ncbi Advanced glycation endproduct induces ROS accumulation, apoptosis, MAP kinase activation and nuclear O-GlcNAcylation in human cardiac myocytes
    Shi Yan Li
    Center for Cardiovascular Research and Alterative Medicine, Division of Pharmaceutical Sciences, University of Wyoming, Laramie, WY 82071, USA
    Life Sci 80:1051-6. 2007
    ..Collectively, these results indicated that AGE or its precursor MG may trigger ROS generation, apoptosis, MAPK activation and nuclear O-GlcNAcylation in human cardiac myocytes, in a manner reminiscent of high extracellular glucose...
  76. ncbi Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology
    A K Berner
    Centre for Vision and Vascular Science, Queen s University Belfast, Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland, UK
    Diabetologia 55:845-54. 2012
    ..Using a transgenic rat model that overexpresses GLO1, we investigated if this enzyme can inhibit retinal AGE formation and prevent key lesions of diabetic retinopathy...
  77. ncbi Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats
    Xiaoxia Wang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Kidney Int 66:2315-21. 2004
    ..The role of MG in the development of essential hypertension is unknown, although MG has been extensively studied in relation to diabetes...
  78. ncbi Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis
    Anne Valerie Cantero
    Inserm U 466 and Biochemistry Department, IFR 31, CHU Rangueil, University Paul Sabatier, Toulouse, France
    FASEB J 21:3096-106. 2007
    ..They form adducts on proteins, thereby inducing cellular dysfunctions involved in chronic complications of diabetes...
  79. ncbi Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells
    Björn Kuhla
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Neurosci Res 83:1591-600. 2006
    ..In summary, our data suggest that a reduced glyoxalase I activity mimics some changes associated with neurodegeneration, such as neurite retraction and apoptotic cell death...
  80. ncbi Activation of macrophages and lymphocytes by methylglyoxal against tumor cells in the host
    Nivedita Bhattacharyya
    Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700 032, India
    Int Immunopharmacol 8:1503-12. 2008
    ..Methylglyoxal also played a role in the proliferation and cytotoxicity of splenic lymphocytes. In short, it can be concluded that methylglyoxal profoundly stimulates the immune system against tumor cells...
  81. pmc A matter of life or death: modeling DNA damage and repair in bacteria
    Jens Karschau
    Institute of Complex Systems and Mathematical Biology, SUPA, King s College, University of Aberdeen, Aberdeen, United Kingdom
    Biophys J 100:814-21. 2011
    ..We verify our analytical results by simulating the stochastic dynamics of DNA damage and repair. Finally, we also perform an experiment with Escherichia coli cells to test one of the predictions of our model...
  82. ncbi Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells
    Tuanjie Chang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    FASEB J 25:1746-57. 2011
    ..It is concluded that MG-induced VSMC proliferation is mediated by the activation of Akt1 via the modification of Akt1 at Cys(77)...
  83. pmc Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy
    Ricardo Gomes
    Centro de Quimica e Bioquimica, Departamento de Quimica e Bioquimica, Faculdade de Ciencias da Universidade de Lisboa, 1749 016 Lisboa, Portugal
    Biochem J 385:339-45. 2005
    ..05 pmol/mg of protein in FAP patients, and it was not detected in control subjects. The presence of argpyrimidine in amyloid deposits from FAP patients supports the view that protein glycation is an important factor in amyloid diseases...
  84. ncbi The origin of methylglyoxal in New Zealand manuka (Leptospermum scoparium) honey
    Christopher J Adams
    Chemistry Department, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand
    Carbohydr Res 344:1050-3. 2009
    ..Nectar washed from manuka flowers contained high levels of dihydroxyacetone and no detectable methylglyoxal...
  85. ncbi Glyoxalase II does not support methylglyoxal detoxification but serves as a general trypanothione thioesterase in African trypanosomes
    Alexandra Wendler
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 504, 69120 Heidelberg, Germany
    Mol Biochem Parasitol 163:19-27. 2009
    ..brucei glyoxalase II. This offers a function for the parasite glyoxalase II as general trypanothione thioesterase independent of ketoaldehyde detoxification...
  86. ncbi The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease
    Naila Rabbani
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK
    Ann N Y Acad Sci 1126:124-7. 2008
    ....
  87. ncbi Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells
    Hui Wang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada
    Biochem Pharmacol 77:1709-16. 2009
    ..These discoveries will help unmask molecular mechanisms for various MG-induced mitochondrial dysfunction-related cellular disorders...
  88. ncbi Methylglyoxal modifies heat shock protein 27 in glomerular mesangial cells
    Anoop K Padival
    Research Service 151 W, Louis Stokes V A Medical Center, Cleveland, OH 44106, USA
    FEBS Lett 551:113-8. 2003
    ..Additional studies showed that MGO-induced modification of Hsp27 decreased its binding to cytochrome c. Our results suggest that Hsp27 is a major target for MGO modification in mesangial cells...
  89. ncbi Potassium channel activation by glutathione-S-conjugates in Escherichia coli: protection against methylglyoxal is mediated by cytoplasmic acidification
    G P Ferguson
    Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, UK
    Mol Microbiol 17:1025-33. 1995
    ..Alterations in the pHi do not accelerate the rate of detoxification of methylglyoxal. The mechanism by which methylglyoxal causes cell death and the implications for pHi-mediated resistance to methylglyoxal are discussed...
  90. pmc Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration
    Yalin Wu
    Department of Ophthalmology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:7275-80. 2010
    ..Whereas various processes play a role in drusen formation, these findings are indicative of a contribution from lipofuscin photooxidation in RPE...
  91. ncbi A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells
    Hyun Kyoung Lee
    Department of Physiology, Medical Science Research, Institute, College of Medicine, Dong A University, Busan, South Korea
    J Neurochem 108:273-84. 2009
    ..Our data indicate that MGO affects cell viability via desensitization of gp130/STAT3 signaling, which is the key signaling pathway for cell survival, and thereby promotes cytotoxicity...
  92. ncbi Methylglyoxal and advanced glycation endproducts: new therapeutic horizons?
    Kaushik Desai
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Recent Pat Cardiovasc Drug Discov 2:89-99. 2007
    ....
  93. ncbi Methylglyoxal: its presence in beverages and potential scavengers
    Di Tan
    Department of Food Science, Rutgers University, New Brunswick, NJ 08901 8529, USA
    Ann N Y Acad Sci 1126:72-5. 2008
    ..In addition, we have discovered that commercial beverages contain extremely high levels of MG. The potential hazardous effects of dietary MG on humans remain to be explored...
  94. ncbi Activation of potassium channels during metabolite detoxification in Escherichia coli
    G P Ferguson
    Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, UK
    Mol Microbiol 9:1297-303. 1993
    ..Inhibition of KefB activity by the addition of 10 mM potassium to the growth medium stimulates methylglyoxal-induced cell death. This establishes an essential physiological function for the KefB system...
  95. ncbi Differential susceptibility of naive and differentiated PC-12 cells to methylglyoxal-induced apoptosis: influence of cellular redox
    Masahiro Okouchi
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Curr Neurovasc Res 2:13-22. 2005
    ..The enhanced vulnerability of nPC12 cells to MG and its relationship to cellular redox shifts will have important implications for understanding differential oxidative vulnerability in various cell types and their transition states...
  96. ncbi Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats
    Xuming Jia
    Department of Pharmacology College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, Canada S7N 5E5
    Mol Cell Biochem 306:133-9. 2007
    ..In conclusion, the increase in endogenous MG accumulation impairs insulin-signaling pathway and decreases insulin-stimulated glucose uptake in adipose tissue, which may contribute to the development of insulin resistance...
  97. ncbi Methylglyoxal: possible link between hyperglycaemia and immune suppression?
    Claire L Price
    Antigen Presentation Research Group, Imperial College London Faculty of Medicine, Level 7W, NWLH campus, Watford Road, Harrow, Middlesex, HA1 3UJ, UK
    Trends Endocrinol Metab 20:312-7. 2009
    ..We suggest that MG could be a missing link between hyperglycaemia and immune suppression in diabetes...
  98. ncbi Methylglyoxal induces cellular damage by increasing argpyrimidine accumulation and oxidative DNA damage in human lens epithelial cells
    Junghyun Kim
    Diabetic Complications Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon, South Korea
    Biochem Biophys Res Commun 391:346-51. 2010
    ..These results suggested that the accumulation of argpyrimidine and oxidative DNA damage caused by MGO are involved in apoptosis of HLE-B3 cells...
  99. ncbi Free radical generation by methylglyoxal in tissues
    Kaushik M Desai
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Drug Metabol Drug Interact 23:151-73. 2008
    ..The findings reported in various studies reviewed have started filling in gaps in our knowledge that will ultimately provide us with a clear picture of how the whole process that causes cellular dysfunction is initiated...
  100. ncbi Identification of DNA adducts of methylglyoxal
    Matthias Frischmann
    Institute of Pharmacy and Food Chemistry, University of Erlangen Nuremberg, Schuhstrasse 19, D 91052 Erlangen, Germany
    Chem Res Toxicol 18:1586-92. 2005
    ..Thereby, CEdG proved to be the most sensitive and suitable marker for the reaction of DNA with MG (negative MRM mode, three mass transitions [M - 1](-) 338-->178, 338-->106, and 338-->149)...
  101. ncbi Vascular methylglyoxal metabolism and the development of hypertension
    Xiaoxia Wang
    Department of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Hypertens 23:1565-73. 2005
    ....

Research Grants22

  1. DNA MODIFICATIONS BY PYRUVALDEHYDE
    Ching Jer Chang; Fiscal Year: 1993
    ..effort is focused on unraveling the structural specificity, dynamics and quantitation of the interactions of pyruvaldehyde with DNA in vitro...
  2. Glycation and mu dicarbonyls in diabetic complications
    Paul Beisswenger; Fiscal Year: 2006
    ..These exciting research projects, and new ones on the horizon, combined with the proposed mentoring/training program offers real opportunities of attracting and rewarding a new generation of clinical investigators. ..
  3. ENZYMATIC CONTROLS OF NONENZYMATIC GLYCATION
    Paul Beisswenger; Fiscal Year: 2005
    ..Increased understanding of the role played by enzymatic mechanisms that determine levels of dicarbonyls and Amadori products and their resulting AGEs is essential if we are to find effective strategies to prevent diabetic nephropathy. ..
  4. Novel Pathways of AGE Formation in Diabetes
    RAM NAGARAJ; Fiscal Year: 2005
    ..Our study is expected to provide novel insights into AGE formation in diabetes and may lead to new pharmacological agents to prevent AGE formation and complications in diabetes. ..
  5. Modifications of Small Heat Shock Proteins in the Lens
    RAM NAGARAJ; Fiscal Year: 2009
    ..These studies will improve our understanding of the interplay between sHsps and metabolic pathways, and they will help us to define the role of sHsps in apoptosis of lens epithelial cells and the implications for cataract formation. ..
  6. Oxidative Stress, VEGF and Retinopathy
    DAVID VANDER JAGT; Fiscal Year: 2004
    ..It provides a testable model that connects hyperglycemia-> oxidative stress-> growth factors-> diabetic retinopathy. ..
  7. Alzheimer's Disease Drugs
    DAVID VANDER JAGT; Fiscal Year: 2008
    ..Versatile schemes to synthesize analogs of resveratrol have been developed. The Specific Aim of this proposal is to test resveratrol and analogs in an animal model of Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  8. Acylation as an Approach to Enhance the Cancer Preventive Effect of EGCG
    Shengmin Sang; Fiscal Year: 2007
    ..2. To determine the bioavailability and efficacy of acylated EGCG in the prevention of ACF formation in the AOM-treated mouse model. ..
  9. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
    ....
  11. Multifunctional reagents for proteomic analysis
    CHRISTIAN SCHONEICH; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  12. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
    ..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
  13. Vascular Response and Glycoxidant Homeostasis
    Helen Vlassara; Fiscal Year: 2009
    ..The elucidation of AGER1 mechanisms, which influence the regulation of AGE clearance (positively) and/or the pro-OS, inflammatory pathways (negatively) may generate new therapeutic targets against human vascular disease. ..
  14. Somatostatin Receptor Based PET Imaging of Gene Transfer
    BUCK ROGERS; Fiscal Year: 2008
    ..This proposal should result in improvement of the existing hSSTR2 reporter system for imaging gene transfer. [unreadable] [unreadable] [unreadable]..
  15. Pulmonary Transgene Expression Imaging with PET
    BUCK ROGERS; Fiscal Year: 2008
    ..The results will demonstrate how PET imaging can be used to study the impact of changes in gene expression on the natural history of disease or to develop therapeutic protocols to alter disease outcome. ..
  16. Heat Induced Suicide Gene Therapy for H and N Surgery
    BUCK ROGERS; Fiscal Year: 2005
    ..abstract_text> ..
  17. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ....
  18. N-acetylcysteine pharmacokinetics--hemodialysis patients
    Richard Ward; Fiscal Year: 2006
    ..abstract_text> ..
  19. AGE-RECEPTORS AND KIDNEY DISEASE
    Helen Vlassara; Fiscal Year: 2003
    ....
  20. AGING AND VASCULAR DISEASE: ROLE OF GLYCATION
    Helen Vlassara; Fiscal Year: 2007
    ..diabetes, diet. The proposed studies will expand our understanding of this basic process and may allow us to identify ways to prevent AGE-induced vascular injury due to diabetes and aging. ..
  21. Proteomic characterization of aging cerebellum
    CHRISTIAN SCHONEICH; Fiscal Year: 2008
    ..Results of these proteomic studies will contribute to emerging databases providing critical insights into brain mechanisms underlying functional decline with age. ..
  22. How Substrates Activate Fumarase and Glyoxalase Evolved
    Irwin Rose; Fiscal Year: 2005
    ..Since methylglyoxal is toxic to cells and must be removed by an active glyoxalse system, inhibition of a MSH based system could result in a treatment for many mycobacterial-based diseases such as tuberculosis. ..