glutaral

Summary

Summary: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.

Top Publications

  1. ncbi Ethanol inhibition of porcine bioprosthetic heart valve cusp calcification is enhanced by reduction with sodium borohydride
    Jeanne M Connolly
    Cardiology Research Laboratory, Children s Hospital of Philadelphia, Abramson Research Center, Suite 702, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    J Heart Valve Dis 13:487-93. 2004
  2. ncbi Cross-linking of human amniotic membrane by glutaraldehyde
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Ophthalmic Res 36:71-7. 2004
  3. ncbi Carbodiimide cross-linked hyaluronic acid hydrogels as cell sheet delivery vehicles: characterization and interaction with corneal endothelial cells
    Pei Lin Lu
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China
    J Biomater Sci Polym Ed 19:1-18. 2008
  4. ncbi Cytotoxicity of glutaraldehyde crosslinked collagen/poly(vinyl alcohol) films is by the mechanism of apoptosis
    Julie E Gough
    School of Biomedical Sciences, E Floor, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    J Biomed Mater Res 61:121-30. 2002
  5. ncbi Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman
    K C Gupta
    Department of Chemistry, Polymer Research Laboratory, Indian Institute of Technology, Roorkee 247 667, India
    Carbohydr Res 341:744-56. 2006
  6. ncbi Effect of desensitizing agents on dentin permeability
    Hiroshi Ishihata
    Department of Restorative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Dent 22:143-6. 2009
  7. ncbi Effect of desensitizing agents on dentin permeability and dentin tubule occlusion
    Justine L Kolker
    Department of Operative Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
    J Adhes Dent 4:211-21. 2002
  8. ncbi Replica of human dentin treated with different desensitizing agents: a methodological SEM study in vitro
    Jose Carlos Pereira
    Dentistry, Endodontics and Dental Materials Department, Bauru School of Dentistry, University of Sao Paulo, Brazil
    Braz Dent J 13:75-85. 2002
  9. ncbi Efficacy of denture disinfection methods in controlling Candida albicans colonization in vitro
    Ralf Buergers
    Department of Prosthetic Dentistry, Regensburg University Medical Centre, Germany
    Acta Odontol Scand 66:174-80. 2008
  10. ncbi Spectroscopic investigation of the function of aqueous 2-hydroxyethylmethacrylate/glutaraldehyde solution as a dentin desensitizer
    Chuangye Qin
    National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
    Eur J Oral Sci 114:354-9. 2006

Research Grants

  1. Human Sensory Irritation From Volitile Organic Compounds
    William Cain; Fiscal Year: 2006
  2. A screen for small molecule inhibitors of soluble Abeta oligomer assembly
    Harry LeVine; Fiscal Year: 2007
  3. Nanotube Reagentless Proteomic Arrays
    Michael Wilson; Fiscal Year: 2007
  4. Enhanced Capillary DNA Sequencing
    Philip Serwer; Fiscal Year: 2004
  5. REGULATION OF EXTRACELLULAR SUPEROXIDE DISMUTASE BY PROT
    Russell Bowler; Fiscal Year: 2004
  6. Rapid Immunoassays for Detecting Pathogenic Bacteria
    Michael Wilson; Fiscal Year: 2004
  7. Determinants of the Durability of Resin-Dentin Bonds
    David Pashley; Fiscal Year: 2006
  8. IRIDIUM OXIDE PROTEIN MICROARRAYS
    Michael Wilson; Fiscal Year: 2002
  9. Assembly Visualized Routine Flourescence Microscopy
    Philip Serwer; Fiscal Year: 2008
  10. DNA Packaging Motors
    Philip Serwer; Fiscal Year: 2005

Detail Information

Publications231 found, 100 shown here

  1. ncbi Ethanol inhibition of porcine bioprosthetic heart valve cusp calcification is enhanced by reduction with sodium borohydride
    Jeanne M Connolly
    Cardiology Research Laboratory, Children s Hospital of Philadelphia, Abramson Research Center, Suite 702, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    J Heart Valve Dis 13:487-93. 2004
    ..The study aim was to investigate whether this was due to unreacted aldehyde residues and other reducible compounds resulting from GA cross-linking...
  2. ncbi Cross-linking of human amniotic membrane by glutaraldehyde
    Eberhard Spoerl
    Department of Ophthalmology, Universitatsklinikum CGC, Dresden, Germany
    Ophthalmic Res 36:71-7. 2004
    ..However, in some diseases the transplant usually dissolves rather quickly and early detachment may occur. Therefore, we tried to stabilize the amniotic transplant by applying glutaraldehyde for collagen cross-linking of the membrane...
  3. ncbi Carbodiimide cross-linked hyaluronic acid hydrogels as cell sheet delivery vehicles: characterization and interaction with corneal endothelial cells
    Pei Lin Lu
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China
    J Biomater Sci Polym Ed 19:1-18. 2008
    ....
  4. ncbi Cytotoxicity of glutaraldehyde crosslinked collagen/poly(vinyl alcohol) films is by the mechanism of apoptosis
    Julie E Gough
    School of Biomedical Sciences, E Floor, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
    J Biomed Mater Res 61:121-30. 2002
    ....
  5. ncbi Glutaraldehyde and glyoxal cross-linked chitosan microspheres for controlled delivery of centchroman
    K C Gupta
    Department of Chemistry, Polymer Research Laboratory, Indian Institute of Technology, Roorkee 247 667, India
    Carbohydr Res 341:744-56. 2006
    ..The linear fractional release of centchroman with the square root of time indicated a Fickian behavior of centchroman, and the microspheres also showed zero-order release kinetics for centchroman...
  6. ncbi Effect of desensitizing agents on dentin permeability
    Hiroshi Ishihata
    Department of Restorative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Am J Dent 22:143-6. 2009
    ..The tested hypothesis was that the products, in spite of different chemical mechanisms were not different at reducing or eliminating flow through dentin discs...
  7. ncbi Effect of desensitizing agents on dentin permeability and dentin tubule occlusion
    Justine L Kolker
    Department of Operative Dentistry, The University of Iowa, Iowa City, Iowa 52242, USA
    J Adhes Dent 4:211-21. 2002
    ..The aim of this study was to evaluate: 1) the effect of five dentin desensitizing agents (DDAs) on permeability using hydraulic conductance, and 2) morphological tubule changes with scanning electron microscopy (SEM)...
  8. ncbi Replica of human dentin treated with different desensitizing agents: a methodological SEM study in vitro
    Jose Carlos Pereira
    Dentistry, Endodontics and Dental Materials Department, Bauru School of Dentistry, University of Sao Paulo, Brazil
    Braz Dent J 13:75-85. 2002
    ..Comparison of the photomicrographs of dentin discs with their respective impressions and resin replicas showed that this technique can reproduce the characteristics of the dentin surface treated with desensitizing agents...
  9. ncbi Efficacy of denture disinfection methods in controlling Candida albicans colonization in vitro
    Ralf Buergers
    Department of Prosthetic Dentistry, Regensburg University Medical Centre, Germany
    Acta Odontol Scand 66:174-80. 2008
    ..The aim of this study was to rank 10 denture disinfection methods according to their efficacy in reducing Candida albicans (C. albicans) colonization on soft denture relining material...
  10. ncbi Spectroscopic investigation of the function of aqueous 2-hydroxyethylmethacrylate/glutaraldehyde solution as a dentin desensitizer
    Chuangye Qin
    National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
    Eur J Oral Sci 114:354-9. 2006
    ..The function of Gluma as a desensitizer to block dentinal tubules occurs via these two reactions...
  11. ncbi Efficiency and cytotoxicity of resin-based desensitizing agents
    Jean Camps
    Laboratoire IMEB, UFR Odontologie, Marseille, France
    Am J Dent 15:300-4. 2002
    ..The tested hypothesis was that their different curing techniques cause variations in efficiency and cytotoxicity...
  12. ncbi The long-term effectiveness of five current desensitizing products on cervical dentine sensitivity
    I Duran
    Department of Periodontology, School of Dentistry, Selcuk University, Konya, Turkey
    J Oral Rehabil 31:351-6. 2004
    ....
  13. ncbi Do conventional cleaning and disinfection techniques avoid the risk of endoscopic Helicobacter pylori transmission?
    M Nurnberg
    Oskar Ziethen Hospital, Lichtenberg, Berlin, Germany
    Endoscopy 35:295-9. 2003
    ..pylori transmission...
  14. ncbi GI flexible endoscope disinfection: "in use" test comparative study
    Josep M Bordas
    GI Endoscopy, Motility and Functional Tests, Institut de Malalties Digestives, Institut Malalties Digestives, Hospital Clinic, Facultat de Medicina Universitat de Barcelona, Barcelona, Spain
    Hepatogastroenterology 52:800-7. 2005
    ..The "in use" method is adequate for control and for establishing comparisons between different disinfectants...
  15. ncbi Synthesis of cross-linked enzyme aggregates (CLEAs) in CO2-expanded micellar solutions
    Jing Chen
    Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    Colloids Surf B Biointerfaces 48:72-6. 2006
    ..This method has some advantages in applications and can be easily applied to the synthesis of other cross-linked enzyme aggregates...
  16. ncbi Surface fixation of dried blood by glutaraldehyde and peracetic acid
    G Kampf
    Bode Chemie GmbH and Co, Development, Melanchthonstr 27, 22525 Hamburg, Germany
    J Hosp Infect 57:139-43. 2004
    ..3%). Our findings underline the potential for blood fixation, not only by glutaraldehyde, but also by peracetic acid, and support the evidence that effective cleaning should precede the chemical disinfection...
  17. ncbi A prospective study of the efficacy of routine decontamination for gastrointestinal endoscopes and the risk factors for failure
    Linda Bisset
    Department of Infectious Diseases and Immunology and The Australian Centre for Hepatitis Virology, The University of Sydney, Australia
    Am J Infect Control 34:274-80. 2006
    ..Patient-ready endoscopes were monitored over an 80-week period to determine the efficacy of decontamination procedures in a busy endoscopy center. Decontamination failure was related to patient and procedural parameters...
  18. pmc Chemical disinfection of hepatitis A virus on environmental surfaces
    J N Mbithi
    Department of Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario, Canada
    Appl Environ Microbiol 56:3601-4. 1990
    ..9%; phenolics, iodine-based products, alcohols, and solutions of acetic, peracetic, citric, and phosphoric acids were unable to do so...
  19. ncbi Survival of enveloped and non-enveloped viruses on surfaces compared with other micro-organisms and impact of suboptimal disinfectant exposure
    R Howie
    Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada
    J Hosp Infect 69:368-76. 2008
    ..chelonae. Breakthrough survival was detected at 0.1% glutaraldehyde and 0.05% AHP for all organisms tested. Our data emphasise the need for effective cleaning and disinfection in nosocomial settings to prevent pathogen transmission...
  20. ncbi Identification and characterization of an organic solvent tolerance gene in Helicobacter pylori
    Hung Chuan Chiu
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Helicobacter 12:74-81. 2007
    ..However, some chemical-solvent-tolerant bacteria may survive after incomplete endoscopic disinfection. The goal of this study was to identify glutaraldehyde resistance-related genes in Helicobacter pylori...
  21. ncbi A crosslinked inclusion body process for sialic acid synthesis
    Jozef Nahalka
    Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Bratislava, Slovak Republic
    J Biotechnol 134:146-53. 2008
    ..The required substrate, N-acetyl-D-mannosamine, was obtained by partially improved alkaline epimerization...
  22. ncbi Molecular detection of methionine in rat brain using specific antibodies
    A Amara
    Laboratoire d Immunologie et Pathologie, Universite de Bordeaux II, France
    Neurosci Lett 185:147-50. 1995
    ..Using purified antibodies diluted at 1/20,000, motoneurons were found to be the most methionine-immunoreactive cell bodies in glutaraldehyde-fixed rat brain sections...
  23. ncbi In vitro dentine permeability evaluation of HEMA-based (desensitizing) products using split-chamber model following in vivo application in the dog
    I Duran
    Selcuk University, School of Dentistry, 42079 Konya, Turkey
    J Oral Rehabil 32:34-8. 2005
    ..The Gluma Desensitizing agent provide the more lasting tubule-occluding effect than the other material tested in this model...
  24. ncbi Closing of dentinal tubules by Gluma desensitizer
    P Schupbach
    Institute of Oral Microbiology and General Immunology, University of Zurich, Switzerland
    Eur J Oral Sci 105:414-21. 1997
    ..It is concluded that glutaraldehyde can intrinsically block dentinal tubules. The septa in the tubules may counteract the hydrodynamic mechanism for dentinal sensitivity...
  25. ncbi Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking
    A Bigi
    Department of Chemistry G Ciamician, University of Bologna, Italy
    Biomaterials 22:763-8. 2001
    ....
  26. ncbi Treatment of bioprosthetic heart valve tissue with long chain alcohol solution to lower calcification potential
    Chandrashekar P Pathak
    CarboMedics, 1300 East Anderson Lane, Austin, Texas 78752 1793, USA
    J Biomed Mater Res A 69:140-4. 2004
    ..These data, taken together, support the notion that treatment of glutaraldehyde-treated tissue with a short and long chain alcohol combination will reduce both extractable phospholipids and the propensity for in vivo calcification...
  27. ncbi Peritoneal regeneration induced by an acellular bovine pericardial patch in the repair of abdominal wall defects
    Po Hong Lai
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan, R O C
    J Surg Res 127:85-92. 2005
    ..This study was to evaluate the feasibility of using an acellular bovine pericardium fixed with genipin (AGP) to repair an abdominal wall defect created in a rat model...
  28. ncbi [Immunogenicity of bovine jugular vein conduits treated with different cross-linking methods]
    Hui Wang
    Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:176-8. 2005
    ..To evaluate the immunogenicity of bovine jugular vein conduits (BJVCs) treated with different cross-linking methods...
  29. ncbi Preparation and characterization of nanoparticles containing trypsin based on hydrophobically modified chitosan
    Chen Guang Liu
    Life Science College, Ocean University of China, Qingdao 266003, People s Republic of China
    J Agric Food Chem 53:1728-33. 2005
    ..9 mg/mL) was higher than that of pure TR (50.2 mg/mL). However, the thermal stability and optimum temperature of TR immobilized on nanoparticles improved, which make it more attractive in the application aspect...
  30. ncbi Surface fabrication of hollow microspheres from N-methylated chitosan cross-linked with glutaraldehyde
    Xianghong Peng
    Department of Chemistry, Wuhan University, Wuhan 430072, China
    Langmuir 21:1091-5. 2005
    ..In addition, an anti-infective drug, ofloxacin (Floxin), encapsulated in the microspheres more rapidly released to reach 90 wt % at pH 7.4 within 8 h than at pH 1.2...
  31. ncbi Effects of matrix stabilization when using glutaraldehyde on the material properties of porcine meniscus
    Shawn A Hunter
    Noyes Giannestras Biomechanics Laboratories, Department of Biomedical Engineering, 860 Engineering Research Center, University of Cincinnati, Cincinnati, Ohio 45221 0048, USA
    J Biomed Mater Res A 67:1245-54. 2003
    ..02% resulted in tissues with material properties no different from the untreated controls. We conclude that minimal concentrations of glutaraldehyde (less than 0.2%) should be used in future studies to preserve normal meniscus properties...
  32. ncbi Adsorption of anionic dyes on chitosan beads. 1. The influence of the chemical structures of dyes and temperature on the adsorption kinetics
    Antonio R Cestari
    Laboratory of Materials and Calorimetry, Departamento de Química CCET, Universidade Federal de Sergipe, CEP 49000 000, Sao Cristovao, Sergipe, Brazil
    J Colloid Interface Sci 280:380-6. 2004
    ..Adsorption data of the dyes in relation to the contact time, the chemical structures of the dyes, and temperature were presented and were discussed...
  33. ncbi ADAPT-treated porcine valve tissue (cusp and wall) versus Medtronic Freestyle and Prima Plus: crosslink stability and calcification behavior in the subcutaneous rat model
    William M L Neethling
    Fremantle Heart Institute and University of Western Australia, Department of Cardiothoracic, Fremantle Hospital, Western Australia
    J Heart Valve Dis 13:689-96; discussion 696. 2004
    ....
  34. ncbi Preparation and characterisation in simulated body conditions of glutaraldehyde crosslinked chitosan membranes
    R M Silva
    Department of Polymer Engineering, University of Minho, Campus de Azurem, 4800 058 Guimaraes, Portugal
    J Mater Sci Mater Med 15:1105-12. 2004
    ..Weight loss measurements showed that the developed membranes degrade slowly up to 60 days. Cytotoxicity screening, using cell culture tests, showed that eventually such materials could be adequate for use in biomedical applications...
  35. ncbi Thermal dehydration treatment and glutaraldehyde cross-linking to increase the biostability of collagen-chitosan porous scaffolds used as dermal equivalent
    Lie Ma
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
    J Biomater Sci Polym Ed 14:861-74. 2003
    ..These results suggest that the GA-treated scaffold has an increased biostability and excellent biocompatibility. It can be a potential candidate for skin-tissue engineering...
  36. ncbi Viscoelastic characterizations of acellular dermal matrix (ADM) preparations for use as injectable implants
    Hsiu O Ho
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan, Republic of China
    J Biomed Mater Res A 70:83-96. 2004
    ..Similarly, viscoelastic characteristics of the ADM preparations examined were also so sensitive to temperature that the persistence of ADM preparations after implantation at body temperature would deteriorate...
  37. ncbi Immunoelectron microscopy study of polyamines using a newly prepared monoclonal antibody against spermidine: use of a mixture of glutaraldehyde and paraformaldehyde as a cross-linking agent in the preparation of the antigen
    Toshio Tanabe
    Diagnostic Agent Development Office, Nippon Kayaku, 1 11 2 Fujimi, Chiyoda ku, Tokyo 102 8172
    J Biochem 135:501-7. 2004
    ..These results are in complete agreement with the results obtained by our recent ICC method using another mAb (ASPM-29) produced against GA-conjugated Spm...
  38. ncbi A novel in situ gel for sustained drug delivery and targeting
    Sudipta Ganguly
    Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
    Int J Pharm 276:83-92. 2004
    ..Inclusion of GMO enhanced the mucoadhesive property of chitosan by three- to sevenfold. This novel in situ gel system can be useful in the sustained delivery of drugs via oral as well as parenteral routes...
  39. ncbi [Methods for the pre-treatment of biological tissues for vascular scaffold]
    Xixun Yu
    Institute of Biomedical Engineering, West Chin Center of Medical Sciences, Sichuan University, Chengdu 610041, China
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 21:476-81. 2004
    ..Meanwhile, dye-mediated photooxidation crosslink is also a promising pre-treatment which should be widely applied in vascular scaffold...
  40. ncbi An amperometric acetylthiocholine sensor based on immobilization of acetylcholinesterase on a multiwall carbon nanotube-cross-linked chitosan composite
    Dan Du
    Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan, 430079, China
    Anal Bioanal Chem 387:1059-65. 2007
    ..10 micromol L(-1). Fabrication reproducibility of the sensor was good and the stability was acceptable. The sensor is a promising new tool for characterization of enzyme inhibitors and for pesticide analysis. Abstract...
  41. ncbi Production of lipase in a fermentor using a mutant strain of Corynebacterium species: its partial purification and immobilization
    Nityananda Roy
    Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata 700 032, India
    Indian J Exp Biol 42:202-7. 2004
    ..1 micromol/min and 14.7% respectively. Ca2+ (5 mM) was found to be stimulator for enzyme activity. Immobilized lipase retained 68.18% of the original activity when stored for 40 days...
  42. ncbi Mechanical properties of electrospun fibrinogen structures
    Michael C McManus
    Department of Surgery, Virginia Commonwealth University, Richmond, 23298 0230, USA
    Acta Biomater 2:19-28. 2006
    ..In conclusion, the mechanical characteristics of electrospun fibrinogen strongly support its potential use as a tissue engineering scaffold or wound dressing...
  43. ncbi Synthesis, characterization and immunogenicity of silk fibroin-L-asparaginase bioconjugates
    Yu Qing Zhang
    Silk Biotechnology Laboratory, School of Life Science, Soochow University, No 1 Shizi Street, Suzhou, Jiangsu 215006, PR China
    J Biotechnol 120:315-26. 2005
    ..SF-ASNase bioconjugates could overcome the common shortcomings of the native form. Therefore, the modified ASNase coupled with silk fibroin has the potential values of being studied and developed as a new bioconjugate drug...
  44. ncbi Preparation and properties of invertase immobilized on a poly(maleic anhydride-hexen-1) membrane
    Hidayet Mazi
    Department of Chemistry, Faculty of Science, Hacettepe University, 06532, Ankara, Turkey
    J Biomater Sci Polym Ed 17:821-35. 2006
    ..Immobilization improved the pH stability of the enzyme, as well as its temperature stability. Immobilized samples obtained were stable and could be used many times over a period of 2 months without considerable activity loss...
  45. ncbi Glutaraldehyde cross-linking of lipases adsorbed on aminated supports in the presence of detergents leads to improved performance
    Gloria Fernandez-Lorente
    Departamento de Biocatalisis, Instituto de Catalisis CSIC, Campus UAM, Cantoblanco, Madrid, Spain
    Biomacromolecules 7:2610-5. 2006
    ..This strategy seems to be of general use to improve the lipase activity to be used in macroaqueous media...
  46. ncbi A multi-step approach in anti-calcification of glutaraldehyde-preserved bovine pericardium
    W M L Neethling
    Fremantle Heart Institute, Fremantle Hospital, School of Surgery and Pathology, University of Western Australia, Fremantle, Western Australia
    J Cardiovasc Surg (Torino) 47:711-8. 2006
    ....
  47. ncbi Cross-linking chitosan nanofibers
    Jessica D Schiffman
    Department of Materials Science and Engineering, Drexel University, Philadelphia, Pennsylvania 19104, USA
    Biomacromolecules 8:594-601. 2007
    ....
  48. ncbi Preparation and characterization of glutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlled delivery of pazufloxacin mesilate
    Yan fei Liu
    College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
    Int J Biol Macromol 41:87-93. 2007
    ..The release profiles of PM from OCMC microspheres were found to be biphasic with a burst release followed by a gradual release phase, and followed the Higuchi matrix model...
  49. ncbi Calcium alginate entrapped preparations of Aspergillus oryzae beta galactosidase: its stability and applications in the hydrolysis of lactose
    Toshiba Haider
    Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, UP, India
    Int J Biol Macromol 41:72-80. 2007
    ..This entrapped crosslinked concanavalin A-beta galactosidase complex retained 95% activity after seventh repeated use and 93% of its original activity even after 2 months storage at 4 degrees C...
  50. ncbi Covalent attachment of cholesterol oxidase and horseradish peroxidase on perlite through silanization: activity, stability and co-immobilization
    Seyed Fakhreddin Torabi
    Department of Biotechnology, University College of Science, University of Tehran, Tehran, Iran
    J Biotechnol 131:111-20. 2007
    ..Immobilized COD showed inhibition in its activity at high cholesterol concentration which was not reported for soluble COD before. Co-immobilized enzymes retained 65% of its initial activity after 20 consecutive reactor batch cycles...
  51. ncbi Monolithic macroporous albumin/chitosan cryogel structure: a new matrix for enzyme immobilization
    Martin Hedström
    Department of Biotechnology, Lund University, P O Box 124, 22100, Lund, Sweden
    Anal Bioanal Chem 390:907-12. 2008
    ..The low hydraulic resistance of the matrix allowed for the development of a generic, high-performance online protein digestion system utilizing the wall-bound proteases...
  52. ncbi Two biosensors for phenolic compounds based on mushroom (Agaricus bisporus) homogenate: comparison in terms of some important parameters of the biosensors
    Mustafa Teke
    Faculty of Science and Arts, Chemistry Department, Mugla University, Mugla, Turkiye
    Prep Biochem Biotechnol 38:51-60. 2008
    ..The aim of the study was to compare the two biosensors in terms of their repeatability and thermal, pH, and operational stability; also, the linear ranges of the two biosensors were compared with each other...
  53. ncbi Histological evaluation of biocompatibility of lyophilized bovine pericardium implanted subcutaneously in rats
    Marina J S Maizato
    Bioengineering Division Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Artif Organs 32:268-71. 2008
    ..The implanted lyophilized samples presented a trend for a reduced inflammatory reaction. Lyophilization of the bovine pericardium does not seem to increase the above listed tissue reaction...
  54. ncbi Preparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process
    Lian Yan Wang
    State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P O Box 353, Beijing 100080, China
    Colloids Surf B Biointerfaces 50:126-35. 2006
    ..5-4.0, the molar ratio of amino group of chitosan to aldehyde group of glutaraldehyde was 1:1 and the crosslinking time of glutaraldehyde was 60 min...
  55. ncbi Reduction of flatus-inducing factors in soymilk by immobilized alpha-galactosidase
    Dhananjay S Kulkarni
    Department of Biochemistry, Gulbarga University, Gulbarga 585 106, Karnataka, India
    Biotechnol Appl Biochem 45:51-7. 2006
    ..The immobilized enzyme was used repeatedly ten times without any change in the performance of the immobilized enzyme in fluidized-bed reactor. The results obtained are of considerable interest for industrial purposes...
  56. ncbi Reduction of calcification of carbodiimide-processed heart valve tissue by prior blocking of amine groups with monoaldehydes
    Frank Everaerts
    Medtronic Inc, Minneapolis, USA
    J Heart Valve Dis 15:269-77. 2006
    ..Failure of implanted bioprostheses due to calcification is a commonly occurring phenomenon. In order to prevent calcification, many alternative cross-linking methods to glutaraldehyde (GA) have been developed and evaluated...
  57. ncbi Cell-free xenogenic vascular grafts fixed with glutaraldehyde or genipin: in vitro and in vivo studies
    Yen Chang
    Division of Cardiovascular Surgery, Veterans General Hospital Taichung and College of Medicine, National Yang Ming University, Taipei, Taiwan, ROC
    J Biotechnol 120:207-19. 2005
    ..Nevertheless, the H-A-GP graft was superior to the H-A-GA graft in completeness of endothelialization on its luminal surface, and thus precluded thrombus formation...
  58. ncbi Diamine-extended glutaraldehyde- and carbodiimide crosslinks act synergistically in mitigating bioprosthetic aortic wall calcification
    Peter Zilla
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    J Heart Valve Dis 14:538-45. 2005
    ....
  59. ncbi An in vivo study of tricalcium phosphate and glutaraldehyde crosslinking gelatin conduits in peripheral nerve repair
    Ming Hong Chen
    Institute of Biomedical Engineering, National Taiwan University, No 1, Sec 1, Jen Ai Road, Taipei, Taiwan
    J Biomed Mater Res B Appl Biomater 77:89-97. 2006
    ..The difference reached a significant level at 24 weeks. Thus, the histomorphometric, electrophysiologic, and functional assessments demonstrate that GTG can be a candidate for peripheral nerve repair...
  60. ncbi Preparation of cross-linked chitosan microspheres by spray drying: effect of cross-linking agent on the properties of spray dried microspheres
    K G H Desai
    School of Life Sciences and Biotechnology, Korea University, Sungbuk Ku, Seoul, South Korea
    J Microencapsul 22:377-95. 2005
    ..Release of the drug from chitosan-TPP, chitosan-FA and chitosan-GA matrices followed Fick's law of diffusion...
  61. ncbi Structural elements of bulk chromatin within metaphase chromosomes
    Juan Manuel Caravaca
    Departament de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Chromosome Res 13:725-43. 2005
    ....
  62. ncbi Adsorption of lipase on hollow fiber membrane chips
    Marwan M Shamel
    Terengganu Advanced Technical Institute, Jalan Panchor, Teluk Kalong, Kemaman, Terengganu Darul Iman, Malaysia
    Artif Cells Blood Substit Immobil Biotechnol 33:423-33. 2005
    ..However, increasing the concentration of the cross-linking agent has a low effect on the amount of lipase adsorbed...
  63. ncbi pH-sensitive behavior of two-component hydrogels composed of N,O-carboxymethyl chitosan and alginate
    Fwu Long Mi
    Division of Applied Chemistry, Department of Applied Science, Chinese Naval Academy, 669 Jiun Shiaw Road, Kaohsiung, Taiwan 813, ROC
    J Biomater Sci Polym Ed 16:1333-45. 2005
    ..The aforementioned results indicated that the swelling behaviors and drug-release profiles of these test hydrogels are significantly different due to their distinct cross-linking structures...
  64. ncbi Crosslinked chitosan implants as potential degradable devices for brachytherapy: in vitro and in vivo analysis
    Abdel Kareem Azab
    Department of Pharmaceutics, The Hebrew University of Jerusalem, School of Pharmacy, P O Box 12065, Jerusalem 91120, Israel
    J Control Release 111:281-9. 2006
    ..It is concluded that hydrogels made of crosslinked Ct are potential novel, safe, degradable devices for brachytherapy...
  65. ncbi Structural requirements for stabilization of vascular elastin by polyphenolic tannins
    Jason C Isenburg
    Cardiovascular Implant Research Laboratory, Department of Bioengineering, Clemson University, 501 Rhodes Engineering Research Center, Clemson, SC 29634, USA
    Biomaterials 27:3645-51. 2006
    ....
  66. ncbi An amperometric enzyme electrode for creatine determination prepared by the immobilization of creatinase and sarcosine oxidase in poly(vinylferrocenium)
    Pinar Esra Erden
    Department of Chemistry, Faculty of Science, Ankara University, Ankara, Turkey
    Artif Cells Blood Substit Immobil Biotechnol 34:223-39. 2006
    ..5, 37 degrees C, 2.5:1 (CI:SO) and 0.05 M, respectively. The stability and reproducibility of the enzyme electrode have been also studied...
  67. ncbi Preparation and characterization of cross-linked enzyme aggregates (CLEA) of subtilisin for controlled release applications
    K Sangeetha
    Chemical Science and Technology Division, Regional Research Laboratory CSIR, Trivandrum 695019, India
    Int J Biol Macromol 43:314-9. 2008
    ..Application of these pH-sensitive beads for the controlled release of subtilisin in vitro was studied and found to be a feasible strategy...
  68. ncbi Role of elastin in pathologic calcification of xenograft heart valves
    Michael T Bailey
    Department of Bioengineering, 501 Rhodes Engineering Research Center, Clemson University, Clemson, South Carolina 29634, USA
    J Biomed Mater Res A 66:93-102. 2003
    ..Our results also demonstrate the importance of studying elastin-oriented calcification in decellularized elastin-rich aortic matrices currently used in tissue-engineering applications...
  69. ncbi Inflammatory and immune processes: the neglected villain of bioprosthetic degeneration?
    P Human
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town Medical School, Cape Town, South Africa
    J Long Term Eff Med Implants 11:199-220. 2001
    ..Finally we present evidence for a role of circulating antibodies in bioprosthesis calcification...
  70. ncbi Glutaraldehyde-fixed kangaroo aortic wall tissue: histology, crosslink stability and calcification potential
    W M L Neethling
    Fremantle Heart Institute and University of Western Australia, Fremantle Hospital, Fremantle, Western Australia
    J Biomed Mater Res B Appl Biomater 66:356-63. 2003
    ..The reduced calcification potential could result in improved long-term durability of stentless kangaroo heart valves as bioprostheses...
  71. ncbi Detoxification on top of enhanced, diamine-extended glutaraldehyde fixation significantly reduces bioprosthetic root calcification in the sheep model
    Ameli E Trantina-Yates
    Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town, South Africa
    J Heart Valve Dis 12:93-100; discussion 100-1. 2003
    ..The study aim was to demonstrate the combined effect of all three treatments in a circulatory sheep model...
  72. ncbi Degeneration of bioprosthetic heart valve cusp and wall tissues is initiated during tissue preparation: an ultrastructural study
    Dan T Simionescu
    Cardiovascular Implant Research Laboratory, Department of Bioengineering, Clemson University, Clemson, South Carolina 29634, USA
    J Heart Valve Dis 12:226-34. 2003
    ....
  73. ncbi Stress state during fixation determines susceptibility to fatigue-linked biodegradation in bioprosthetic heart valve materials
    Sean D Margueratt
    School of Biomedical Engineering, Dalhousie University, 5981 University Avenue, Halifax, Nova Scotia, Canada B3H3J5
    Biomed Sci Instrum 38:145-50. 2002
    ..There were significant decreases in the mechanical properties and an increase in the amount of collagen solubilized with increased exposure to fatigue cycling...
  74. ncbi Biocompatibility study of biological tissues fixed by a natural compound (reuterin) produced by Lactobacillus reuteri
    Hsing Wen Sung
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Biomaterials 23:3203-14. 2002
    ..Additionally, reuterin fixation may inhibit tissue calcification as compared to glutaraldehyde fixation. These observations implied that the biocompatibility of the reuterin-fixed tissue is superior to the glutaraldehyde-fixed tissue...
  75. ncbi Feasibility study using a natural compound (reuterin) produced by Lactobacillus reuteri in sterilizing and crosslinking biological tissues
    Chiun Nan Chen
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013
    J Biomed Mater Res 61:360-9. 2002
    ..In conclusion, the results obtained in this study indicate that reuterin is an effective agent in the sterilization and fixation of biological tissues...
  76. ncbi Behavior and properties of neat and filled gelatins
    M Usta
    Department of Materials Science and Engineering, Gebze Institute of Technology, Kocaeli, Turkey 41400
    Biomaterials 24:165-72. 2003
    ..The cross-linking led to different coordinations following the formaldehyde vs. the glutaraldehyde treatments...
  77. ncbi Influence of species, environmental factors, and tissue cellularity on calcification of porcine aortic wall tissue
    B Meuris
    Department of Cardiac Surgery, Katholieke Universiteit Leuven, Leuven, Belgium
    Semin Thorac Cardiovasc Surg 13:99-105. 2001
    ..will be necessary to avoid the inflammation leading to elastolysis and consequent calcification of elastic fibers...
  78. ncbi In vitro evaluation of a chitosan membrane cross-linked with genipin
    F L Mi
    Department of Mathematics, Physics and Chemistry, Chinese Naval Academy, Kaohsiung, Taiwan, ROC
    J Biomater Sci Polym Ed 12:835-50. 2001
    ..The drug-release characteristics of the genipin-cross-linked chitosan membrane are currently under investigation...
  79. pmc High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel
    M Maduke
    Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254 9110, USA
    J Gen Physiol 114:713-22. 1999
    ..Cross-linking studies argue that EriC is a homodimer in both detergent micelles and reconstituted liposomes, a conclusion corroborated by gel filtration and analytical sedimentation experiments...
  80. ncbi Disulfide-mediated oligomerization of Peripherin/Rds and Rom-1 in photoreceptor disk membranes. Implications for photoreceptor outer segment morphogenesis and degeneration
    C J Loewen
    Department of Biochemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 275:5370-8. 2000
    ..Peripherin/Rds containing core complexes interact through specific intermolecular disulfide bonds to form oligomers which may play a crucial role in photoreceptor disc morphogenesis and retinal degenerative diseases...
  81. ncbi Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation
    W K Lee
    Korea Institute of Science and Technology, Biomaterials Research Center, P.O. Box 131, Cheongnyang, Seoul 130-650, Korea
    J Biomed Mater Res 58:27-35. 2001
    ..This simple modification method may be useful for calcification-resistant and blood-compatible tissue patches for cardiovascular implants...
  82. ncbi Collagen-chitosan polymeric scaffolds for the in vitro culture of human epidermoid carcinoma cells
    N Shanmugasundaram
    Biomaterials Division, Central Leather Research Institute, Adyar, Madras, India
    Biomaterials 22:1943-51. 2001
    ..The results of the above studies suggest that the scaffolds prepared from collagen and chitosan can be utilized as a substrate to culture HEp-2 cells and can also be used as an in vitro model to test anticancerous drugs...
  83. ncbi A natural compound (reuterin) produced by Lactobacillus reuteri for biological-tissue fixation
    Hsing Wen Sung
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan
    Biomaterials 24:1335-47. 2003
    ..However, after fixation, it was noted that the reuterin-fixed tissue has comparable free-amino-group content, denaturation temperature, tensile strength, and resistance against enzymatic degradation as the glutaraldehyde-fixed tissue...
  84. ncbi Efficacy of high-level disinfectants for reprocessing GI endoscopes in simulated-use testing
    R L Foliente
    Division of Gastroenterology and Department of Microbiology, Loma Linda University School of Medicine, California, USA
    Gastrointest Endosc 53:456-62. 2001
    ..Several agents are currently approved by the FDA, but published data on their relative efficacies against mycobacteria are lacking. The objective of this study was to determine the efficacy of these agents for high-level disinfection...
  85. ncbi Blue-light induced interaction of LOV domains from Chlamydomonas reinhardtii
    Roger J Kutta
    Institut fur Physikalische und Theoretische Chemie, Universitat Regensburg, Universitatsstrasse 31, 93053 Regensburg, Germany
    Chembiochem 9:1931-8. 2008
    ..A model is presented that accounts for a blue-light-driven change in the quaternary structure of the LOV1 domain and gives hints to the molecular basis of light activation and regulation in LOV-containing proteins...
  86. ncbi Results of therapy and changing prognosis of multiple myeloma during the last 40 years in the region of North and Middle Moravia: group of 562 patients
    Vlastimil Scudla
    3rd Department of Medicine, Palacky University Hospital, Olomouc, Czech Republic
    Hematol J 4:351-7. 2003
    ..The aim of this study was the retrospective assessment of therapy results and the changing prognosis of multiple myeloma (MM) patients from the Middle and North Moravia region of the Czech Republic during the last 40 years...
  87. ncbi Circular dichroism analysis of penicillin G acylase covalently immobilized on silica nanoparticles
    Bertolt Kranz
    Institute for Technical Chemistry, Water Technology and Geotechnology, Forschungszentrum Karlsruhe GmbH, P O Box 3640, 76021 Karlsruhe, Germany
    J Colloid Interface Sci 316:413-9. 2007
    ..9 to 55.8 mg/g. Because of the fact that we found no major changes in the secondary structure, diffusion limitation seems to be the main reason for the decline of the specific activity...
  88. ncbi Non-enzymatic posttranslational modifications of bovine serum albumin by oxo-compounds investigated by chromatographic and electrophoretic methods
    Katerina Mikulikova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague 4, Czech Republic
    J Chromatogr B Analyt Technol Biomed Life Sci 815:315-31. 2005
    ....
  89. ncbi Autoclave sterilization of instruments used on women with cervical neoplasia is an effective method of eradicating residual human papillomavirus DNA: a polymerase chain reaction-based evaluation
    Jacob M Estes
    Division of Gynecologic Oncology, The University of Alabama Birmingham, Birmingham, AL 35249, USA
    J Low Genit Tract Dis 11:12-7. 2007
    ..To determine whether autoclave sterilization eradicates human papillomavirus (HPV) DNA on specula and instruments used to treat women with cervical neoplasia...
  90. ncbi A survey of the appropriate use of antiseptic agents in the operating room of several key health care facilities. A comparison between surveys in 2000 and 2004
    T Shiraishi
    Division of Pharmacy, Yamagata University Hospital, Yamagata 990 9585, Japan
    Dermatology 212:15-20. 2006
    ..Especially, amphoteric detergents and glutaral products showed significant reductions in the total amount used in the 6 hospitals, by 94.8 and 96...
  91. pmc Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects
    Stefan Hahn
    Fraunhofer Institute for Toxicology and Experimental Medicine, Department Chemical Risk Assessment, Nikolai Fuchs Str, 1, 30625 Hanover, Germany
    Environ Health 9:7. 2010
    ....
  92. ncbi Rapid communication: effects of Steris 1 sterilization and Cidex ortho-phthalaldehyde high-level disinfection on durability of new-generation flexible ureteroscopes
    Jose Benito A Abraham
    Department of Urology, University of California Irvine, Orange, California 92868, USA
    J Endourol 21:985-92. 2007
    ..We prospectively studied the effects of Steris 1 sterilization and Cidex ortho-phthalaldehyde (OPA) high-level disinfection (HLD) on the image quality, physical structure, and deflective properties of two new flexible ureteroscopes...
  93. ncbi [The immune enhancement of the C3 to the Escherichia coli vaccine]
    Xue Yun Ma
    Animal Science and Veterinary Medicine College of Shandong Agricultural University, Tai an 271018, China
    Wei Sheng Wu Xue Bao 46:812-5. 2006
    C3b was separated and purified from the SPF chicken serum. It was linked with E. coli antigen by the glutaral. 11 days aged SPF chicken were immunized by the complex antigen and the chickens of control group were immunised by the FCA- E...
  94. ncbi Effect of peracetic acid and aldehyde disinfectants on biofilm
    N Henoun Loukili
    Service de Gestion du Risque Infectieux, University Hospital of Lille, Lille, France
    J Hosp Infect 58:151-4. 2004
    ..Users should be concerned about the efficiency of the cleaning stage of medical devices, and when choosing a PAA product, non-fixing ability should be considered in addition to antimicrobial activity...
  95. ncbi Eimeria bovis meront I-carrying host cells express parasite-specific antigens on their surface membrane
    Ahmed Ibrahem I Badawy
    Institute of Parasitology, Justus Liebig University Giessen, Rudolf Buchheim Str 2, 35392, Giessen, Germany
    Vet Res Commun 34:103-18. 2010
    ..Although the function of EbHCSAg is still unknown, results of this study might suggest an involvement in the development of protective immunity against E. bovis infections...
  96. ncbi Acute glutaraldehyde mucosal injury of the upper aerodigestive tract due to damage to the working channel of an endoscope
    Priya D Krishna
    Division of Laryngology, Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Ann Otol Rhinol Laryngol 119:150-4. 2010
    ..This report details the clinical course of 2 patients who suffered acute glutaraldehyde exposure during office injection procedures...
  97. ncbi Entrapment in E. coli improves the operational stability of recombinant beta-glycosidase CelB from Pyrococcus furiosus and facilitates biocatalyst recovery
    Thomas Kamrat
    Research Centre Applied Biocatalysis, Petersgasse 14, c o Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, A 8010 Graz, Austria
    J Biotechnol 129:69-76. 2007
    ..Entrapment facilitated downstream processing of CelB and biocatalyst recovery in repeated batchwise conversions of lactose at elevated temperatures...
  98. ncbi The effect of sterilization methods on the light transmission characteristics and structure of light-curing tips
    A Kakaboura
    Department of Operative Dentistry, School of Dentistry, University of Athens, Athens, Greece
    J Oral Rehabil 31:918-23. 2004
    ..Water-steam autoclave is safer than the 0.2% sodium dicloroisocyanorate and 2% glutaraldehyde chemical sterilization agents regarding the light transmission characteristics and the structure of the light-curing tips...
  99. ncbi Glyoxal is an important allergen for (medical care) cleaning staff
    W Uter
    Information Network of Departments of Dermatology IVDK, Georg August University, Department of Dermatology, Gottingen, Germany
    Int J Hyg Environ Health 204:251-3. 2001
    ..In conclusion, glyoxal should be tested in all patients with contact dermatitis working in occupations with possible exposure to respective disinfecting/cleaning agents...
  100. ncbi An evaluation of Cidex OPA (0.55% ortho-phthalaldehyde) as an alternative to 2% glutaraldehyde for high-level disinfection of endoscopes
    R P D Cooke
    Department of Infection Prevention and Control, District General Hospital, Eastbourne, East Sussex BN2 2UD, UK
    J Hosp Infect 54:226-31. 2003
    ..The increased cost of changing to Cidex OPA was estimated as pound 7691 per annum. Staining of washer-disinfectors was of concern as it proved very difficult to remove...
  101. ncbi Glutardialdehyde induced fluorescence technique (GIFT): a new method for the imaging of platelet adhesion on biomaterials
    R D Frank
    IZKF Biomat University Hospital RWTH Aachen, Pauwelsstr 30, 52057 Aachen, Germany
    J Biomed Mater Res 52:374-81. 2000
    ..In conclusion, GIFT is a valid, rapid, and simple method for the quantitative determination of platelet/material interactions intended for the evaluation of thrombogenicity of biomaterials surfaces...

Research Grants23

  1. Human Sensory Irritation From Volitile Organic Compounds
    William Cain; Fiscal Year: 2006
    ..F) The effect of inflammation upon chemesthetic sensitivity. G) Through measurement of the NMP, confirmation of the peripheral basis for a) temporal phenomena, b) differences in potency, and c) effects of inflammation. ..
  2. A screen for small molecule inhibitors of soluble Abeta oligomer assembly
    Harry LeVine; Fiscal Year: 2007
    ..Anti-oligomer compounds could potentially block the cognitive impairment symptoms that oligomers elicit in animal models and interfere with the progression of Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  3. Nanotube Reagentless Proteomic Arrays
    Michael Wilson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Enhanced Capillary DNA Sequencing
    Philip Serwer; Fiscal Year: 2004
    ..Each adaptation will help solve a current genomic problem, for example, either closing of a partially assembled genome sequence or performing high accuracy analysis of mutations. ..
  5. REGULATION OF EXTRACELLULAR SUPEROXIDE DISMUTASE BY PROT
    Russell Bowler; Fiscal Year: 2004
    ..This will not only define new aspects of the pathogenesis and regulation of vascular tone and inflammation, but can open new approaches to pharmacologically control these events. ..
  6. Rapid Immunoassays for Detecting Pathogenic Bacteria
    Michael Wilson; Fiscal Year: 2004
    ..EIC has a commercial path for assay technology through in-house manufacturing, sale of electrochemical assays and hand-held assay readers, and out-licensing of our multianalyte immunoassay technology. ..
  7. Determinants of the Durability of Resin-Dentin Bonds
    David Pashley; Fiscal Year: 2006
    ..This should provide important new insight into designing more durable resin-dentin bonds that can justify the placement of resin-based posterior composites. ..
  8. IRIDIUM OXIDE PROTEIN MICROARRAYS
    Michael Wilson; Fiscal Year: 2002
    ..In Phase II, higher density protein arrays suitable for integration into automated, high-throughput microfluidic delivery systems and fluorescent analyzers will be developed. ..
  9. Assembly Visualized Routine Flourescence Microscopy
    Philip Serwer; Fiscal Year: 2008
    ..Applications are anticipated in the analysis of the assembly of disease-causing viruses and determining pathways of oncogenesis. ..
  10. DNA Packaging Motors
    Philip Serwer; Fiscal Year: 2005
    ..Analysis of bacteriophage DNA packaging motors is expected to provide a basis for understanding the role of motors in disease, especially disease caused by a virus that has a DNA packaging motor. ..
  11. Rapid Quantitative Point-of-Care Cardiac Marker Test
    Michael Wilson; Fiscal Year: 2005
    ..EIC has a clear commercial path for assay technology through in-house manufacturing, sale of electrochemical assays and hand-held assay readers, and out-licensing of our multianalyte immunoassay technology. ..
  12. SOLUTE AND FLUID TRANSPORT ACROSS THE CONJUNCTIVA
    OSCAR CANDIA; Fiscal Year: 2002
    ..Based on this model, he will devise protocols to modify and possibly reverse the secretory/absorptive properties of the tissue. ..
  13. Micro-and nano-mechanical and chemical guidance of neurons
    Christine Schmidt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. Fabrication of Novel Biomimetic Polymers Using Combinatorial Peptide Screening
    Christine Schmidt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  15. Mechanically Stable Blood Substitutes
    Andre Francis Palmer; Fiscal Year: 2010
    ..The proposed work is both innovative and significant, because novel LEAcHb hybrid vesicles with engineered structural and mechanical characteristics will be created for use as an artificial blood substitute. ..
  16. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
  17. Measurement of Fluid Flow Across the Ocular Ciliary Body
    OSCAR CANDIA; Fiscal Year: 2006
    ..abstract_text> ..
  18. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  19. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    LAURA NGWENYA; Fiscal Year: 2005
    ..It has been established that cognitive decline occurs with age. This proposed investigation will determine if there are changes in adult cell genesis that could be important in the neurobiological basis of age-related cognitive decline. ..
  20. ANTIBODY MICROARRAY FOR DETECTION OF TUMOR MARKERS
    Michael Wilson; Fiscal Year: 2005
    ..The Phase II will focus on developing a robust, reliable and reproducible assaying system. ..
  21. Enhanced O2 Delivery to C3A Hepatocytes
    Andre Palmer; Fiscal Year: 2009
    ..The knowledge gained from this study is expected to be of benefit in the design of hepatocyte containing HF bioreactors for use as potential BLADs. ..
  22. ENHANCED DURABILITY OF BIOPROSTHETIC HEART VALVES
    Michael Sacks; Fiscal Year: 2004
    ..Determine how chemical treatment alters cuspal layer micromechanics. 2. Quantify PBHV cuspal deformation during the cardiac cycle. 3. Determine how long-term cyclic fatigue alters PBHV later structure and mechanical properties. ..
  23. Fluid Movement across Conjunctiva: Stimulation and Regulation
    OSCAR CANDIA; Fiscal Year: 2007
    ..These studies may provide the groundwork for the design of future treatment modalities for dry-eye syndromes. ..