- Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure
Institute of Molecular Cardiology, Department of Medicine, University of Louisville, 550 South Jackson Street, Louisville, KY 40202, USA
Am J Physiol Heart Circ Physiol 293:H3673-84. 2007
..Accordingly, we examined the myocardial effects of the model unsaturated aldehyde acrolein. In closed-chest mice, intravenous acrolein (0...
- TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
Diana M Bautista
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
Cell 124:1269-82. 2006
..TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and inflammatory actions of tear gas, vehicle exhaust, and metabolic byproducts of ..
- Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
Neuron 41:849-57. 2004
..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain...
- The uremic toxin acrolein promotes suicidal erythrocyte death
Mohamed Siyabeldin E Ahmed
Department of Physiology, University of Tuebingen, Gmelinstraße 5, 72076 Tuebingen, Germany
Kidney Blood Press Res 37:158-67. 2013
..Erythrocytes could be sensitized to cytosolic Ca(2+) by ceramide. In end stage renal disease, eryptosis may possibly be stimulated by uremic toxins. The present study explored, whether the uremic toxin acrolein could trigger eryptosis.
- Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei
Alexander O Gill
Department of Food Science, Faculty of Agriculture and Food Sciences, 250 Ellis Building, 13 Freedman Crescent, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
Appl Environ Microbiol 70:5750-5. 2004
..The possible mechanisms of inhibition of energy generation are inhibition of glucose uptake or utilization of glucose and effects on membrane permeability...
- Acrolein - a pulmonary hazard
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
Mol Nutr Food Res 55:1342-60. 2011
b>Acrolein is a respiratory irritant that can be generated during cooking and is in environmental tobacco smoke...
- Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune encephalomyelitis mouse
Department of Basic Medical Sciences, Center for Paralysis Research, Purdue University, West Lafayette, IN 47907, USA
Neuroscience 173:150-5. 2011
Oxidative stress is considered a major contributor in the pathology of multiple sclerosis (MS). Acrolein, a highly reactive aldehyde byproduct of lipid peroxidation, is thought to perpetuate oxidative stress...
- Attenuation of mouse somatic and emotional inflammatory pain by hydralazine through scavenging acrolein and inhibiting neuronal activation
Department of Anatomy and K K Leung Brain Research Centre, Preclinical School of Medicine, Fourth Military Medical University, China
Pain Physician 15:311-26. 2012
b>Acrolein signaling is important during spinal cord injury; whether it is involved in somatic and emotional pain is not clear. Hydralazine is a potent antihypertensive drug and can scavenge acrolein efficiently.
- The molecular effects of acrolein
J P Kehrer
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
Toxicol Sci 57:6-15. 2000
b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environmental situations, particularly as a component of smoke...
- Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein
Nathan S Alexander
Department of Surgery Division of Otolaryngology, Birmingham, Alabama, USA
Laryngoscope 122:1193-7. 2012
..The objective of the current study was to evaluate the effects of acrolein exposure (a prominent tobacco smoke toxin) on vectorial Cl(-) transport through the major apical anion channel ..
- Subinhibitory concentrations of cinnamaldehyde interfere with quorum sensing
Department of Biology, Georgia State University, Atlanta, GA 30303 USA
Lett Appl Microbiol 43:489-94. 2006
..harveyi BB170 by nearly 60 per cent. CA did not inhibit the growth of the bioreporter strains at these concentrations. CA had a minimal effect on LasR promoter activity, induced by 3-oxo-C12-HSL...
- Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation
Richard M LoPachin
Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
Chem Res Toxicol 22:1499-508. 2009
b>Acrolein and 4-hydroxy-2-nonenal (HNE) are byproducts of lipid peroxidation and are thought to play central roles in various traumatic injuries and disease states that involve cellular oxidative stress, for example, spinal cord trauma, ..
- Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid
Children s Hospital Oakland Research Institute, Oakland, California, USA
Invest Ophthalmol Vis Sci 48:339-48. 2007
..cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial damage in retinal pigment epithelial (RPE) cells ..
- Acrolein-mediated injury in nervous system trauma and diseases
Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 1244, USA
Mol Nutr Food Res 55:1320-31. 2011
b>Acrolein, an α,β-unsaturated aldehyde, is a ubiquitous pollutant that is also produced endogenously through lipid peroxidation...
- Acrolein induces myelin damage in mammalian spinal cord
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA
J Neurochem 117:554-64. 2011
..Here, we show that acrolein, a lipid peroxidation product, can cause significant myelin damage in isolated guinea pig spinal cord segments...
- Error prone translesion synthesis past gamma-hydroxypropano deoxyguanosine, the primary acrolein-derived adduct in mammalian cells
Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555, USA
J Biol Chem 277:18257-65. 2002
..deoxyguanosine, gamma-HOPdG) is a major DNA adduct that forms as a result of exposure to acrolein, an environmental pollutant and a product of endogenous lipid peroxidation...
- Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures
M A Lovell
Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, 101 Sanders-Brown Building, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536-0230, USA
Neurobiol Aging 22:187-94. 2001
..b>Acrolein, an alpha,beta-unsaturated aldehydic product of lipid peroxidation, is approximately 100 times more reactive than ..
- Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid
Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Via Ardeatina 546, 00178, Rome, Italy
Toxicology 170:173-85. 2002
b>Acrolein is a highly reactive unsaturated hazardous air pollutant of human health concern, particularly as a component of cigarette smoke...
- Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp
Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
PLoS ONE 6:e16084. 2011
..However, little is known about the structure-activity relationship of cinnamaldehyde analogs...
- Proteomic profiling of acrolein adducts in human lung epithelial cells
Page C Spiess
Department of Pathology, University of Vermont, Burlington, VT 05405, USA
J Proteomics 74:2380-94. 2011
b>Acrolein (2,3-propenal) is a major indoor and outdoor air pollutant originating largely from tobacco smoke or organic combustion...
- Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells
Centro de Biologia Molecular, CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
J Neurosci Res 71:863-70. 2003
..The effect of the lipid peroxidation product acrolein on these modes of phosphorylation has been assayed...
- Acrolein induces inflammatory response underlying endothelial dysfunction: a risk factor for atherosclerosis
Yong Seek Park
Department of Microbiology and MRC for Bioreaction to ROS, Kyung Hee University School of Medicine, Seoul, Korea
Ann N Y Acad Sci 1126:185-9. 2008
..Our study demonstrates that acrolein, a known toxin in tobacco smoke, elevates oxidative stress via inactivation of thioredoxin reductase and ..
- Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats
Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Eur Respir J 33:1122-32. 2009
..sildenafil, a potent inhibitor of PDE5 that selectively degrades cyclic guanosine 3',5'-monophosphate (cGMP), on acrolein-induced inflammation and mucus production in rat airways was examined...
- Potential role of acrolein in neurodegeneration and in Alzheimer's disease
Thanh Nam Dang
INRS Institut Armand Frappier, 531, boul des Prairies, H7V 1B7 Laval, Quebec, Canada
Curr Mol Pharmacol 3:66-78. 2010
Lipid peroxidation leads to the formation of a number of aldehydes by-products, including acrolein. The most abundant aldehydes are 4-hydroxy-nonenal (4-HNE) and malondialdehyde (MDA) while acrolein is the most reactive...
- Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
Department of Pharmacology, Chiesi Farmaceutici s p a, Parma, Italy
Br J Pharmacol 163:649-61. 2011
..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells...
- CD8+ T cells contribute to macrophage accumulation and airspace enlargement following repeated irritant exposure
Michael T Borchers
Department of Environmental Health, Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
Exp Mol Pathol 83:301-10. 2007
..In this study, we utilize a mouse model of COPD to examine the contributions of CD8(+) T cells in the persistent macrophage accumulation and airspace enlargement resulting from chronic irritant exposure...
- Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase
Ha Won Jeong
Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305 600, South Korea
Biochem Pharmacol 65:1343-50. 2003
..These results support the hypothesis that the cinnamaldehyde derivative CB403 exerts cytostatic properties by inducing mitotic arrest in cancer cells...
- Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells
Departement des Sciences Biologiques, TOXEN, Universite du Quebec a Montreal, Succursale Centre Ville, Canada
Chem Biol Interact 181:154-67. 2009
b>Acrolein is a highly reactive, alpha,beta-unsaturated aldehyde that is an omnipresent environmental pollutant. Humans are exposed to acrolein in food, vapors of overheated cooking oil, cigarette smoke and by combustion of organic products...
- Role of endoplasmic reticulum stress in acrolein-induced endothelial activation
Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
Toxicol Appl Pharmacol 234:14-24. 2009
b>Acrolein is a ubiquitous environmental pollutant and an endogenous product of lipid peroxidation. It is also generated during the metabolism of several drugs and amino acids...
- Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production
Hitesh S Deshmukh
Center for Environmental Genetics, University of Cincinnati, Cincinnati, USA
Am J Respir Cell Mol Biol 38:446-54. 2008
..b>Acrolein, a constituent of cigarette smoke and an endogenous mediator of oxidative stress, increases airway mucin 5, ..
- Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta
Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama, Japan
Biol Pharm Bull 29:2415-8. 2006
..Endothelium-dependent relaxation is affected by nitric oxide, and one of the mechanisms of endothelium-independent relaxation is thought to be influenced by the blocking of Ca2+ channels...
- Cinnamaldehyde inhibits the tumor necrosis factor-alpha-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-kappaB activation: effects upon IkappaB and Nrf2
Being Chyuan Liao
Department of Microbiology and Immunology, National Chiayi University, Chiayi, Taiwan
Toxicol Appl Pharmacol 229:161-71. 2008
..Hence, our present findings indicate that cinnamaldehyde suppresses TNF-induced singling pathways via two distinct mechanisms that are activated by different pretreatment periods...
- Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair
Department of Environmental Medicine, Pathology, and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
Proc Natl Acad Sci U S A 103:15404-9. 2006
..However, compared with other carcinogenic compounds, such as aldehydes, the amount of PAHs in CS is minute. Acrolein (Acr) is abundant in CS, and it can directly adduct DNA...
- TRPA1 agonists evoke coughing in guinea pig and human volunteers
Mark A Birrell
Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
Am J Respir Crit Care Med 180:1042-7. 2009
..Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood...
- Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke
S Patrick Nana-Sinkam
The Ohio State University, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
Am J Respir Crit Care Med 175:676-85. 2007
..Prostacyclin (PGI(2)) is a major product of the cyclooxygenase pathway with potent vasodilatory and antimitogenic properties and may be relevant to endothelial dysfunction in COPD...
- α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells
Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
J Nutr Biochem 21:1222-31. 2010
..We investigated α-tocopherol's inducing effect on Phase II enzymes and its protective effect on acrolein-induced toxicity in a human retinal pigment epithelial (RPE) cell line, ARPE-19...
- Cinnamaldehyde--a potential antidiabetic agent
P Subash Babu
Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India
Phytomedicine 14:15-22. 2007
..05) reduction in blood glucose concentration in STZ-induced diabetic rats. The results of this experimental study indicate that cinnamaldehyde possesses hypoglycemic and hypolipidemic effects in STZ-induced diabetic rats...
- Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease
Taufika Islam Williams
Department of Chemistry, University of Kentucky, 135 Sanders Brown Center on Aging, Lexington, KY 40506, USA
Neurobiol Aging 27:1094-9. 2006
..of lipid peroxidation and neurotoxic by-products of lipid peroxidation including 4-hydroxynonenal (HNE) and acrolein in vulnerable regions of the Alzheimer's disease (AD) brain...
- Regulation of constitutive neutrophil apoptosis by the alpha,beta-unsaturated aldehydes acrolein and 4-hydroxynonenal
Erik I Finkelstein
Dept of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave Burlington, VT 05405, USA
Am J Physiol Lung Cell Mol Physiol 289:L1019-28. 2005
..induce apoptotic cell death in various cell types, we recently observed that the alpha,beta-unsaturated aldehyde acrolein (ACR) can inhibit constitutive apoptosis of polymorphonuclear neutrophils and thus potentially contribute to ..
- Protein modification by acrolein: formation and stability of cysteine adducts
Department of Pharmacology and Toxicology, Division of Cardiology, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Chem Res Toxicol 22:708-16. 2009
The toxicity of the ubiquitous pollutant and endogenous metabolite, acrolein, is due in part to covalent protein modifications. Acrolein reacts readily with protein nucleophiles via Michael addition and Schiff base formation...
- Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential
Soumya J Koppikar
Interactive Research School for Health Affairs IRSHA, Bharati Vidyapeeth University Medical College Campus, Pune, Maharashtra, India
BMC Cancer 10:210. 2010
..In the present study, we have reported the anti-neoplastic activity of cinnamon in cervical cancer cell line, SiHa...
- Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease
Jan F Stevens
Department of Pharmaceutical Sciences, Oregon State University, Corvallis, OR, USA
Mol Nutr Food Res 52:7-25. 2008
b>Acrolein (2-propenal) is ubiquitously present in (cooked) foods and in the environment...
- Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
J Biol Chem 273:16058-66. 1998
..In the present study, we provide evidence that the formation of the toxic pollutant acrolein (CH2=CH-CHO) and its conjugate with lysine residues is involved in the oxidative modification of human low ..
- The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients
Timothy B Adams
Flavor and Extract Manufacturers Association, 1620 I Street, N W, Suite 925, Washington, DC 20006, USA
Food Chem Toxicol 42:157-85. 2004
..Scientific data relevant to the safety evaluation of the use of cinnamyl derivatives as flavoring ingredients is evaluated...
- Acrolein induces endoplasmic reticulum stress and causes airspace enlargement
Pulmonary and Critical Care Medicine Division, The Victoria Johnson Laboratory for Obstructive Lung Disease Research, Virginia Commonwealth University, Richmond, Virginia, United States of America
PLoS ONE 7:e38038. 2012
Given the relative abundance and toxic potential of acrolein in inhaled cigarette smoke, it is surprising how little is known about the pulmonary and systemic effects of acrolein...
- Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis
Hsiang Tsui Wang
Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA
Carcinogenesis 34:220-7. 2013
b>Acrolein (Acr), an α,β-unsaturated aldehyde, is abundant in tobacco smoke and cooking and exhaust fumes. Acr induces mutagenic α- and γ- hydroxy-1,N(2)-cyclic propano-deoxyguanosine adducts in normal human bronchial epithelial cells...
- Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells
School of Natural Sciences, University of California, Merced, P O Box 2039, Merced, CA 95340, USA
Am J Respir Cell Mol Biol 38:483-90. 2008
..b>Acrolein is an alpha,beta-unsaturated aldehyde present in cigarette smoke and also a product of lipid peroxidation...
- Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility
Hsiang Tsui Wang
Department of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA
J Biol Chem 287:12379-86. 2012
b>Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic α- and γ-hydroxy-1, N(2)-cyclic propano-2'-deoxyguanosine adducts (α-OH-Acr-dG and γ-OH-Acr-dG)...
- Induction of thioredoxin reductase as an adaptive response to acrolein in human umbilical vein endothelial cells
Yong Seek Park
Department of Biochemistry, Graduate School of Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Biochem Biophys Res Commun 327:1058-65. 2005
b>Acrolein is a highly electrophilic alpha,beta-unsaturated aldehyde to which humans are exposed in a variety of environment situations and is also a product of lipid peroxidation...
- High-performance liquid chromatography and capillary electrophoresis: methodological challenges for the determination of biologically relevant low-aliphatic aldehydes in human saliva
Dipartimento di Biochimica A Castellani, Universita di Pavia, Pavia, Italy
Electrophoresis 25:1255-63. 2004
..Low-aliphatic aldehydes, such as formaldehyde, acetaldehyde and acrolein, are among the main components of mainstream cigarette smoke and their local noxious and carcinogenic effects in ..
- Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, People s Republic China
Mitochondrion 6:136-42. 2006
b>Acrolein is an air pollutant from cigarette smoking and other pollutions and also a by-product of lipid peroxidation...
- Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells
Dept of Pharmacology, Chiesi Farmaceutici, Parma, Italy
Am J Physiol Lung Cell Mol Physiol 303:L929-38. 2012
..CSE-evoked elevation of IL-8 mRNA was mimicked by its component acrolein. Both CSE and acrolein induced p38 mitogen-activated protein kinase (MAPK) phosphorylation, accompanied by the ..
- Effect of acrolein and glutathione depleting agents on thioredoxin
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, PHAR Pharmacology, 1 University Station A1915, Austin, TX 78712 0125, USA
Toxicology 204:209-18. 2004
b>Acrolein is a widespread environmental pollutant that reacts rapidly with nucleophiles, especially cellular thiols...
- Acrolein induced DNA damage, mutagenicity and effect on DNA repair
Moon shong Tang
Department of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10967, USA
Mol Nutr Food Res 55:1291-300. 2011
b>Acrolein (Acr) is a ubiquitous environmental contaminant; it also can be generated endogenously by lipid peroxidation...
- Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue
Department of Basic Medical Sciences, Center for Paralysis Research, Institute for Applied Neurology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA
Neurochem Int 44:475-86. 2004
b>Acrolein, a byproduct of oxidative stress and lipid peroxidation, has been implicated in neurodegenerative disorders such as Alzheimer's disease, but not in spinal cord trauma, as a possible key factor in neuronal degeneration...
- Potentiation of antifungal activity of amphotericin B by essential oil from Cinnamomum cassia
Laboratoire de Botanique, Cryptogamie et Biologie Cellulaire, Faculte de Pharmacie, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Phytother Res 20:58-61. 2006
..1 microL/mL of essential oil. This potentiation of amphotericin B obtained in vitro may show promise for the development of less toxic and more effective therapies especially for the treatment of HIV infection...
- Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway
Chae E Kim
Department of Pharmacology, Pusan National University, Yangsan, Gyeongnam 626 870, Korea
Toxicol Appl Pharmacol 245:76-82. 2010
Episodic exposure to acrolein-rich pollutants has been linked to acute myocardial infarction, and 5-lipoxygenase (5-LO) is involved in the production of matrix metalloproteinase-9 (MMP-9), which destabilizes atherosclerotic plaques...
- Involvement of the glutamatergic system in the nociception induced intrathecally for a TRPA1 agonist in rats
J Z Klafke
Programa de Pós Graduação em Ciências Biológicas Bioquímica Toxicológica, Universidade Federal de Santa Maria, 97105 900 Santa Maria, RS, Brazil
Neuroscience 222:136-46. 2012
..Then the modulation of spinal TRPA1 might be a valuable target in painful conditions associated with central pain hypersensitivity...
- Inhibitory effects of phosphodiesterase 5 inhibitor, tadalafil, on mechanosensitive bladder afferent nerve activities of the rat, and on acrolein-induced hyperactivity of these nerves
Department of Urology, Antwerp University Hospital and Antwerp University, Faculty of Medicine, Antwerp, Belgium
BJU Int 110:E259-66. 2012
..One of the mechanisms of tadalafil on LUTS is added in the study...
- Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
Department of Environmental Health Sciences, Division of Toxicological Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2179, USA
Toxicol Lett 132:27-36. 2002
b>Acrolein, an alpha,beta-unsaturated aldehyde, is by far the strongest electrophile present in cigarette smoke which is involved in several lung pathophysiological conditions. Acrolein depletes glutathione and creates thiol imbalance...
- Role of by-products of lipid oxidation in Alzheimer's disease brain: a focus on acrolein
INRS Institut Armand Frappier, Laval, PQ, Canada
J Alzheimers Dis 21:741-56. 2010
..formation of a number of aldehydes by-products, including malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), and acrolein. The most abundant aldehydes are HNE and MDA while acrolein is the most reactive...
- Acrolein health effects
ATSDR, Division of Toxicology and Environmental Medicine, Atlanta, Georgia, USA
Toxicol Ind Health 24:447-90. 2008
b>Acrolein is a chemical used as an intermediate reactive aldehyde in chemical industry. It is used for synthesis of many organic substances, methionine production, and methyl chloride refrigerant...
- Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein
Research Center for Advanced Science and Technology, The University of Tokyo, Komaba, Meguro, Tokyo 153-8904, Japan
Carcinogenesis 22:935-41. 2001
..An early event during exposure to AAPH and SIN-1 was the generation of acrolein, a highly mutagenic lipid peroxidation product, which was suppressed by the addition of alpha-tocopherol...
- Influence of environmental parameters on production of the acrolein precursor 3-hydroxypropionaldehyde by Lactobacillus reuteri DSMZ 20016 and its accumulation by wine lactobacilli
Institute for Plant Biotechnology, Genetics Department, Stellenbosch University, Matieland 7602, Stellenbosch, South Africa
Int J Food Microbiol 137:28-31. 2010
..Wine quality can be gravely compromised by the accumulation of 3-HPA, due to its spontaneous conversion to acrolein under wine making conditions...
- A model of hemorrhagic cystitis induced with acrolein in mice
C K L P Batista
Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceara, Fortaleza, CE, Brasil
Braz J Med Biol Res 39:1475-81. 2006
b>Acrolein is a urinary metabolite of cyclophosphamide and ifosfamide, which has been reported to be the causative agent of hemorrhagic cystitis induced by these compounds...
- Acute acrolein-induced cystitis in mice
Dale E Bjorling
Department of Surgical Sciences, School of Veterinary, University of Wisconsin, Madison, WI 53706, USA
BJU Int 99:1523-9. 2007
To develop a method of direct intravesical administration of acrolein and evaluate the severity of cystitis in response to increasing doses of acrolein in female C57BL/6N (C57) mice, with further studies to compare the severity of acute ..
- Determination of acrolein and other carbonyls in cigarette smoke using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine
Department of Environmental Health, National Institute of Public Health, Wako City, Saitama 351 0197, Japan
J Chromatogr A 1217:4383-8. 2010
A new method for the determination of acrolein and other carbonyls in cigarette smoke using a dual cartridge system has been developed. Each cartridge consists of reagent-impregnated silica particles...
- Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase
Hoi Seon Lee
Research Center for Industrial Development of Biofood Materials and Institute of Agricultural Science and Technology, College of Agriculture, Chonbuk National University, Chonju 561 756, South Korea
J Agric Food Chem 50:7700-3. 2002
..As a naturally occurring therapeutic agent, trans-cinnamaldehyde could be useful for developing new types of NO inhibitors...
- The effects of acrolein on the thioredoxin system: implications for redox-sensitive signaling
Charles R Myers
Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Mol Nutr Food Res 55:1361-74. 2011
The reactive aldehyde acrolein is a ubiquitous environmental pollutant and is also generated endogenously. It is a strong electrophile and reacts rapidly with nucleophiles including thiolates...
- The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase
Department of Pathology, College of Medicine, University of Vermont, Burlington, 05405, USA
Am J Respir Cell Mol Biol 46:23-33. 2012
..innate immune system is often compromised by tobacco smoke exposure, and previous studies have indicated that acrolein, a reactive electrophile in tobacco smoke, may contribute to the immunosuppressive effects of smoking...
- Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention
Eng Hui Chew
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore 117543
Free Radic Biol Med 48:98-111. 2010
..These Michael acceptor molecules can potentially be exploited for use in different concentrations in chemotherapeutic and chemopreventive strategies...
- Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway
Ya Juan Chen
Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China
Int Immunopharmacol 10:685-93. 2010
..cellular functions in the lung, we sought to investigate whether the Ras inhibitor simvastatin could attenuate acrolein-induced mucin production in rat airways...
- Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy
Mohamed Ameen Ismahil
Department of Medicine, Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40202, USA
Am J Physiol Heart Circ Physiol 301:H2050-60. 2011
Environmental triggers of dilated cardiomyopathy are poorly understood. Acute exposure to acrolein, a ubiquitous aldehyde pollutant, impairs cardiac function and cardioprotective responses in mice...
- Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy-trans-2-nonenal
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, PR China
Chem Res Toxicol 22:1721-7. 2009
b>Acrolein (ACR) and 4-hydroxy-trans-2-nonenal (HNE) are two cytotoxic lipid-derived alpha,beta-unsaturated aldehydes which have been implicated as causative agents in the development of carbonyl stress-associated pathologies...
- 2-hydroxycinnamaldehyde inhibits SW620 colon cancer cell growth through AP-1 inactivation
Chung Woo Lee
College of Pharmacy, Chungbuk National University, Korea
J Pharmacol Sci 104:19-28. 2007
..These results suggested that HCA has the most potent inhibitory effect against human colon cancer cell growth, and AP-1 may be an important target of HCA...
- Application of physiological computational fluid dynamics models to predict interspecies nasal dosimetry of inhaled acrolein
Jeffry D Schroeter
The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
Inhal Toxicol 20:227-43. 2008
b>Acrolein is a highly soluble and reactive aldehyde and is a potent upper-respiratory-tract irritant...
- Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal
M L Iersel
Department of Toxicology, Wageningen Agricultural University, Netherlands
Chem Biol Interact 102:117-32. 1996
..The reactive acrolein did not inhibit the DNPSG-excretion at 2.5 microM, the highest non-toxic concentration...
- Melatonin suppresses acrolein-induced IL-8 production in human pulmonary fibroblasts
Gun Dong Kim
Department of Microbiology BK21, School of Medicine, Kyung Hee University, Hoegi dong, Seoul, Korea
J Pineal Res 52:356-64. 2012
..Furthermore, recent studies show that, α, β-unsaturated aldehyde acrolein in CS induces the production of interleukin (IL)-8, which is known to be related to bronchitis, rhinitis, ..
- Genome-wide transcriptional responses to acrolein
Colin A Thompson
Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, The University of Western Australia, Perth WA 6009, Australia
Chem Res Toxicol 21:2245-56. 2008
The lipid peroxidation product and environmental pollutant acrolein participates in many diseases...
- A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia
University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA
Curr Eye Res 37:1045-53. 2012
b>Acrolein has been implicated in retinal pigment epithelium (RPE) cell death, and has been associated with diabetic retinopathy...
- Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
Mi Kyoung Kwak
Department of Environmental Health Sciences, Johns Hopkins University, Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 305:662-70. 2003
..by spermidine treatment, but could be inhibited by the amine oxidase inhibitor, aminoguanidine, suggesting that acrolein or hydrogen peroxide generated from polyamines by serum amine oxidase may be mediators for phase 2 enzyme ..
- Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR
Laboratory of Pharmaceutical Microbiology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
BMC Microbiol 8:149. 2008
..The compounds were also evaluated in an in vivo assay measuring the reduction of Vibrio harveyi virulence towards Artemia shrimp...
- Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment
Department of Urology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
Eur Urol 59:264-71. 2011
It has been suggested that nitric oxide (NO) affects the afferent pathways innervating the bladder. In addition, acrolein, a metabolite of cyclophosphamide, causes bladder hypersensitivity in rats.
- Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients
Graduate School of Pharmaceutical Sciences, Chiba University, 1 33 Yayoi cho, Inage Ku, Chiba 263 8522, Japan
Biochem Biophys Res Commun 305:143-9. 2003
..been suggested to be one of the uremic "toxins," the levels of each polyamine, its oxidized product, acrolein, and amine oxidase in plasma of patients with renal failure were investigated...
- Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations
Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Faculty of Pharmacy, Via Mangiagalli 25, 20133 Milan, Italy
J Pharm Biomed Anal 47:596-602. 2008
b>Acrolein (ACR) is a well-known carbonyl toxin produced by lipid peroxidation of polyunsaturated fatty acids, which is involved in several life-threatening pathologies such as Alzheimer disease, arteriosclerosis, diabetes, and nephropathy...
- Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice
Laura A Wheat
Diabetes and Obesity Center, Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40292, USA
Arterioscler Thromb Vasc Biol 31:1598-606. 2011
b>Acrolein is a toxic chemical present in tobacco, wood, and coal smoke, as well as automobile exhaust...
- Reduced 293T cell susceptibility to acrolein due to aldose reductase-like-1 protein expression
Department of Medical Microbiology, Immunology, and Cell Biology, SimmonsCooper Cancer Institute, Southern Illinois University School of Medicine, Springfield, IL 62702, USA
Toxicol Sci 97:562-8. 2007
b>Acrolein is a highly reactive alpha,beta-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living environments, posing serious threats to human health if not properly metabolized...
- Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein
Larry G Higgins
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK
Toxicol Appl Pharmacol 226:328-37. 2008
..Priming of nrf2(+/+) MEFs, but not nrf2(-/-) MEFs, with C+K conferred 2-fold resistance towards acrolein.
- Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection
Guang Wu Wang
Department of Physiology and the Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Mol Cell Cardiol 44:1016-22. 2008
..Mice were gavage-fed the alpha, beta-unsaturated aldehyde acrolein (5mg/kg) or water (vehicle) 24h prior to a 30-min coronary artery occlusion and 24-hour reperfusion...
- Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Free Radic Biol Med 40:21-34. 2006
..AD), oxidative stress-induced lipid peroxidation leads to accumulation of unsaturated aldehydes including acrolein and 4-hydroxynonenal (4HNE) in brain...
- Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction
Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Circulation 112:2812-20. 2005
..However, a role for MPO in formation of aldehydes in vivo and the functional consequences of MPO-generated oxidants in ischemia/reperfusion models of MI have not been established...
- The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human beta-defensin 2 by sinonasal epithelial cells
Won Kyung Lee
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 0910, USA
Am J Rhinol 21:658-63. 2007
..b>Acrolein (AC) is a major component of cigarette smoke that has been shown to suppress innate immune gene expression by ..
- Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice
Diabetes and Obesity Center, University of Louisville, Louisville, KY 40202, USA
Atherosclerosis 215:301-8. 2011
b>Acrolein is a dietary aldehyde that is present in high concentrations in alcoholic beverages and foods including cheese, donuts and coffee...
- Doxycycline attenuates acrolein-induced mucin production, in part by inhibiting MMP-9
Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, China
Eur J Pharmacol 650:418-23. 2011
..have been found to increase the expression of epidermal growth factor (EGF) receptor, a possible regulator of acrolein-induced mucin expression in the airway epithelium...
- Critical role of acrolein in secondary injury following ex vivo spinal cord trauma
Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana 47907, USA
J Neurochem 107:712-21. 2008
..The lipid peroxidation byproduct acrolein has been implicated as one potential mediator of secondary injury...
- Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells
College of Pharmacy, Kyung Hee University, Hoegi dong, Dongdaemun ku, Seoul 130 701, South Korea
Cancer Lett 196:143-52. 2003
..This is the first report on the mechanism of the anticancer effect of cinnamaldehyde...
- Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking
Steven G Carmella
The Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Chem Res Toxicol 20:986-90. 2007
Recently published data suggest that acrolein (1), a toxic but weakly carcinogenic constituent of cigarette smoke, may be involved as a causative factor for the mutations frequently observed in the p53 tumor suppressor gene in lung cancer ..
- Effects of cinnamaldehyde on PGE2 release and TRPV4 expression in mouse cerebral microvascular endothelial cells induced by interleukin-1beta
Yue ying Ma
Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China
Biol Pharm Bull 31:426-30. 2008
..End3 cells. In conclusion, cinnamaldehyde decreased the production of PGE2 and the expression of TRPV4 in b.End3 cells induced by IL-1beta...
- Functionalized mesoporous silica nanoparticle-based drug delivery system to rescue acrolein-mediated cell death
Purdue University, Center for Paralysis Research, School of Veterinary Medicine, West Lafayette, IN 47907, USA
Nanomedicine (Lond) 3:507-19. 2008
..These agents restore damaged cell membranes and ameliorate abnormal mitochondria behavior induced by the endogenous toxin acrolein. Such a formulation shows potential as a novel therapeutic agent.
- Acrolein, IL-6 and CRP as markers of silent brain infarction
Chiba University, Inohana, Chuo Ku, Japan
Atherosclerosis 203:557-62. 2009
..increased levels of polyamine oxidase (PAO) [acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)], and acrolein (CH(2)CHCHO) are good markers of stroke...
- Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses
Department of Biological Sciences and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, TN 38152 3560, USA
Free Radic Biol Med 50:1-13. 2011
..N-ethylmaleimide (NEM) showed no cross-protection against each other, whereas another thiol-reactive chemical, acrolein, elicited Yap1-dependent cross-protection against NEM, but not H(2)O(2)...