Summary: Organic compounds containing a carbonyl group in the form -CHO.

Top Publications

  1. ncbi Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 274:2234-42. 1999
  2. ncbi Chemical interactions in diatoms: role of polyunsaturated aldehydes and precursors
    Joséphine Leflaive
    Laboratoire d Ecologie Fonctionnelle EcoLab, UMR 5245 CNRS UPS INPT, Universite Paul Sabatier, Toulouse, France
    New Phytol 184:794-805. 2009
  3. ncbi Age and nutrient limitation enhance polyunsaturated aldehyde production in marine diatoms
    Francois Ribalet
    Stazione Zoologica Anton Dohrn di Napoli, Villa Comunale, I80121 Napoli, Italy
    Phytochemistry 68:2059-67. 2007
  4. ncbi Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom
    Adrianna Ianora
    Ecophysiology Laboratory, Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    Nature 429:403-7. 2004
  5. ncbi 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University 464 8601, Nagoya, Japan
    Prog Lipid Res 42:318-43. 2003
  6. ncbi Role of reactive aldehyde in cardiovascular diseases
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Free Radic Biol Med 28:1685-96. 2000
  7. ncbi Lipid peroxidation dysregulation in ischemic stroke: plasma 4-HNE as a potential biomarker?
    Wan Chi Lee
    Department of Neurology, Kaohsiung Medical University, No 100, Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Biochem Biophys Res Commun 425:842-7. 2012
  8. pmc The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal
    Henry Jay Forman
    School of Natural Sciences, University of California, Merced, 4225 N Hospital Road, Building 1200, Merced, CA 95344, USA
    Arch Biochem Biophys 477:183-95. 2008
  9. ncbi Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
    Juan I Garaycoechea
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 489:571-5. 2012
  10. ncbi Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
    Frederic Langevin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 475:53-8. 2011

Detail Information

Publications393 found, 100 shown here

  1. ncbi Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    J Biol Chem 274:2234-42. 1999
  2. ncbi Chemical interactions in diatoms: role of polyunsaturated aldehydes and precursors
    Joséphine Leflaive
    Laboratoire d Ecologie Fonctionnelle EcoLab, UMR 5245 CNRS UPS INPT, Universite Paul Sabatier, Toulouse, France
    New Phytol 184:794-805. 2009
    ..Among these compounds, polyunsaturated short-chain aldehydes in vitro strongly impair the reproduction of various potential grazers...
  3. ncbi Age and nutrient limitation enhance polyunsaturated aldehyde production in marine diatoms
    Francois Ribalet
    Stazione Zoologica Anton Dohrn di Napoli, Villa Comunale, I80121 Napoli, Italy
    Phytochemistry 68:2059-67. 2007
    ..In nutrient-replete cultures, the production of potentially defensive polyunsaturated aldehydes (PUA) increases from the exponential to the stationary phase of growth from 1.2 fmol cell(-1) (+/-0...
  4. ncbi Aldehyde suppression of copepod recruitment in blooms of a ubiquitous planktonic diatom
    Adrianna Ianora
    Ecophysiology Laboratory, Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    Nature 429:403-7. 2004
    ..Mortality remained high even if larvae were switched to the dinoflagellate diet. Aldehydes, cleaved from a fatty acid precursor by enzymes activated within seconds after crushing of the cell, elicit the ..
  5. ncbi 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
    Koji Uchida
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University 464 8601, Nagoya, Japan
    Prog Lipid Res 42:318-43. 2003
    ..In the present review, I provide a comprehensive summary of HNE, as the product and mediator or oxidative stress...
  6. ncbi Role of reactive aldehyde in cardiovascular diseases
    K Uchida
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya, Japan
    Free Radic Biol Med 28:1685-96. 2000
    There is increasing evidence that aldehydes generated endogenously during the degradation process of biological molecules are involved in many of the pathophysiologies associated with cardiovasular diseases such as atherosclerosis and ..
  7. ncbi Lipid peroxidation dysregulation in ischemic stroke: plasma 4-HNE as a potential biomarker?
    Wan Chi Lee
    Department of Neurology, Kaohsiung Medical University, No 100, Shih Chuan 1st Road, Kaohsiung 807, Taiwan
    Biochem Biophys Res Commun 425:842-7. 2012
    ..Taken together, our study suggests that the plasma 4-HNE level is a potential biomarker for ischemic stroke...
  8. pmc The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal
    Henry Jay Forman
    School of Natural Sciences, University of California, Merced, 4225 N Hospital Road, Building 1200, Merced, CA 95344, USA
    Arch Biochem Biophys 477:183-95. 2008
  9. ncbi Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
    Juan I Garaycoechea
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 489:571-5. 2012
    ..We have recently shown that the Fanconi anaemia DNA-repair pathway counteracts the genotoxic effects of reactive aldehydes. Mice with combined inactivation of aldehyde catabolism (through Aldh2 knockout) and the Fanconi anaemia DNA-..
  10. ncbi Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
    Frederic Langevin
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 475:53-8. 2011
    Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA damage...
  11. ncbi Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells
    Atsushi Ishikado
    Division of Endocrinology and Metabolism, Department of Medicine, Shiga University of Medical Science, Seta tsukinowa cho, Otsu, Shiga 520 2192, Japan
    Biochem Biophys Res Commun 402:99-104. 2010
    ..This resulted in prevention of oxidative stress-induced cytotoxicity, and may represent a possible mechanism to partly explain the cardioprotective effects of n-3 PUFAs...
  12. pmc Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
    Satori A Marchitti
    University of Colorado Health Sciences Center, Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, 4200 East Ninth Avenue, C238, Denver, Colorado 80262, USA
    Expert Opin Drug Metab Toxicol 4:697-720. 2008
    b>Aldehydes are highly reactive molecules...
  13. pmc Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
    Anna Liisa Levonen
    Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, Biomedical Research Building II, 901 19th Str S, Birmingham, AL 35294, USA
    Biochem J 378:373-82. 2004
  14. pmc 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
    Marcello Trevisani
    Department of Critical Care Medicine and Surgery, Florence University, 4 50121 Florence, Italy
    Proc Natl Acad Sci U S A 104:13519-24. 2007
    ..Our results also provide a mechanism-based rationale for developing novel analgesic or anti-inflammatory agents that target HNE production or TRPA1 activation...
  15. ncbi Oxidative stress and cell signalling
    G Poli
    Department of Clinical and Biological Sciences, University of Torino, S Luigi Hospital, 10043 Orbassano Torino, Italy
    Curr Med Chem 11:1163-82. 2004
  16. pmc Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase
    Douglas M Warui
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
    J Am Chem Soc 133:3316-9. 2011
    ..Two possible resolutions to this conundrum are suggested...
  17. ncbi Evidence for only oxygenative cleavage of aldehydes to alk(a/e)nes and formate by cyanobacterial aldehyde decarbonylases
    Ning Li
    Department of Biochemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 51:7908-16. 2012
    Cyanobacterial aldehyde decarbonylases (ADs) catalyze the conversion of C(n) fatty aldehydes to formate (HCO(2)(-)) and the corresponding C(n-1) alk(a/e)nes...
  18. ncbi HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages
    Seung J Lee
    Department of Pharmacology and BK21 Medical Science Education Center, School of Medicine, Pusan National University, Yangsan, Gyeongnam 626 870, Korea
    Cardiovasc Res 88:352-9. 2010
    ..To determine the potential role for HNE in 5-LO expression, the molecular mechanisms of 5-LO expression were evaluated in HNE-stimulated macrophages...
  19. ncbi 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest
    G Poli
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
    Med Res Rev 28:569-631. 2008
  20. ncbi Apoptosis signalling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway
    Ozgur Kutuk
    Biological Sciences and Bioengineering Program, Sabanci University, Orhanli, Tuzla Istanbul, Turkey
    Redox Rep 12:30-4. 2007
    ..JNK-dependent induction of c-Jun/AP-1 activation data in the literature indicates a critical potential role for JNK in the cellular response against toxic products of lipid peroxidation...
  21. pmc Dynamics of dissolved and particulate polyunsaturated aldehydes in mesocosms inoculated with different densities of the diatom Skeletonema marinoi
    Charles Vidoudez
    Friedrich Schiller University, Institute of Inorganic and Analytical Chemistry, Jena, Germany
    Mar Drugs 9:345-58. 2011
    A survey of the production of polyunsaturated aldehydes (PUA) of manipulated plankton communities is presented here...
  22. pmc Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function
    Peter V Usatyuk
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Microvasc Res 83:45-55. 2012
    Lipid peroxidation of polyunsaturated fatty acids generates bioactive aldehydes, which exhibit pro- and anti-inflammatory effects in cells and tissues...
  23. ncbi DNA damage induced by endogenous aldehydes: current state of knowledge
    Georgia Persephoni Voulgaridou
    Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, 68100, Greece
    Mutat Res 711:13-27. 2011
    ..and cell processes such as lipid peroxidation and glycation induce the formation of highly reactive endogenous aldehydes that react directly with DNA, form aldehyde-derived DNA adducts and lead to DNA damage...
  24. pmc Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease
    D Allan Butterfield
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington KY 40506 0055, USA
    Biochim Biophys Acta 1801:924-9. 2010
    ..Based on the research conducted so far in the area of lipid peroxidation, it is suggested that lipid accessible antioxidant molecules could be a promising therapeutic approach to treat or slow progression of MCI and AD...
  25. pmc Oxidative stress and covalent modification of protein with bioactive aldehydes
    Paul A Grimsrud
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 283:21837-41. 2008
    ..hydroxyl radical leads to the formation of lipid hydroperoxides that produce a family of alpha,beta-unsaturated aldehydes. Such reactive aldehydes are subject to Michael addition reactions with the side chains of lysine, histidine, ..
  26. ncbi alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases
    Nadia Moretto
    Department of Pharmacology, Chiesi Farmaceutici SpA, Via Palermo 26 A, 43100, Parma, Italy
    Am J Physiol Lung Cell Mol Physiol 296:L839-48. 2009
    ..We examined here the acute effect of aqueous cigarette smoke extract (CSE) and of two alpha,beta-unsaturated aldehydes (acrolein and crotonaldehyde) contained in CSE in cultured normal human lung fibroblasts and small airway ..
  27. ncbi Survey of the chemical defence potential of diatoms: screening of fifty one species for alpha,beta,gamma,delta-unsaturated aldehydes
    Thomas Wichard
    Max Planck Institute for Chemical Ecology, Hans Knoill Str 8, D 07745 Jena, Germany
    J Chem Ecol 31:949-58. 2005
    In recent years a negative influence of diatom-derived alpha,beta,gamma,delta-unsaturated aldehydes (PUA) on the reproductive success of copepods and invertebrates has been suggested...
  28. ncbi Toxigenic effects of diatoms on grazers, phytoplankton and other microbes: a review
    Adrianna Ianora
    Functional and Evolutionary Ecology Laboratory, Stazione Zoologica Anton Dohrn, Naples, Italy
    Ecotoxicology 19:493-511. 2010
    ..The cytotoxic compounds responsible for these effects are short chain polyunsaturated aldehydes (PUAs) and other oxygenated fatty acid degradation products such as hydroxides, oxo-acids, and epoxyalcohols (..
  29. ncbi Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls
    Giancarlo Aldini
    Institute of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, University of Milan, Viale Abruzzi 42, I 20131, Milan, Italy
    Med Res Rev 27:817-68. 2007
    ..Most of the biological effects of intermediate RCS, mainly alpha,beta-unsaturated aldehydes, di-aldehydes, and keto-aldehydes, are due to their capacity to react with the nucleophilic sites of proteins, ..
  30. pmc Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes
    Hongqiao Zhang
    School of Natural Science, University of California at Merced, Merced, CA 95343, USA
    Toxicol Ind Health 25:269-78. 2009
    ..It is also suggested that commercial kinase inhibitors may produce non-specific effects on phase II gene expression via mechanisms unrelated to their purported specificity...
  31. ncbi 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
    Irfan Rahman
    Respiratory Medicine Unit, ELEGI Laboratory, University of Edinburgh Medical School, Wilkie Building, Teviot Place, Edinburgh EH8 9AG, Scotland, UK
    Am J Respir Crit Care Med 166:490-5. 2002
    ..01). The elevated levels of 4-HNE may play a role in the signaling events in lung inflammation leading to the imbalance of the expression of both proinflammatory mediators and protective antioxidant genes in COPD...
  32. ncbi YqhD: a broad-substrate range aldehyde reductase with various applications in production of biorenewable fuels and chemicals
    Laura R Jarboe
    Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA
    Appl Microbiol Biotechnol 89:249-57. 2011
    ..As a scavenger of toxic aldehydes produced by lipid peroxidation, YqhD has reductase activity for a broad range of short-chain aldehydes, ..
  33. pmc Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Exp Gerontol 44:625-33. 2009
    ..The recent development of low molecular weight molecules that scavenge HNE suggests that HNE can be targeted in the design of drugs for the treatment of obesity, the metabolic syndrome, and associated disorders...
  34. ncbi Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells
    Bradford G Hill
    Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202, USA
    Biochem J 410:525-34. 2008
    Proteins modified by aldehydes generated from oxidized lipids accumulate in cells during oxidative stress and are commonly detected in diseased or aged tissue...
  35. pmc Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde
    Heng Ma
    Department of Physiology, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, China
    Eur Heart J 32:1025-38. 2011
    ..The present study was designed to examine the mechanism involved in mitochondrial aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion (I/R) injury with a focus on autophagy...
  36. pmc HSF1-mediated BAG3 expression attenuates apoptosis in 4-hydroxynonenal-treated colon cancer cells via stabilization of anti-apoptotic Bcl-2 proteins
    Aaron T Jacobs
    Department of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, and Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 284:9176-83. 2009
    ..Overall, our data reveal that BAG3 is HSF1-inducible and has a unique role facilitating cancer cell survival during pro-apoptotic stress by stabilizing the level of Bcl-2 family proteins...
  37. ncbi Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10467, USA
    Chem Res Toxicol 22:1499-508. 2009
    ..Specifically, these aldehydes are classified as type 2 alkenes and are characterized by an alpha,beta-unsaturated carbonyl structure...
  38. pmc Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents
    Eunice Andre
    Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    J Clin Invest 118:2574-82. 2008
    ..We hypothesized that 2 alpha,beta-unsaturated aldehydes present in CS, crotonaldehyde and acrolein, induce neurogenic inflammation by stimulating TRPA1, an excitatory ..
  39. ncbi Alpha,beta-unsaturated aldehydes in cigarette smoke release inflammatory mediators from human macrophages
    Fabrizio Facchinetti
    Department of Pharmacology, Chiesi Pharmaceuticals SpA, Parma, Italy
    Am J Respir Cell Mol Biol 37:617-23. 2007
    ..chromatography/mass spectrometry (GC/MS) we show that acrolein and crotonaldehyde, two alpha,beta-unsaturated aldehydes, are contained in aqueous cigarette smoke extract (CSE) at micromolar concentrations and mimic CSE in evoking ..
  40. ncbi Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes
    Hans Jörg Martin
    Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Kiel, Germany
    Chem Biol Interact 178:145-50. 2009
    ..Among the best characterized intermediates of oxidative stress are the unsaturated aldehydes 4-hydroxynon-2-enal (4-HNE) and its oxidized counterpart 4-oxonon-2-enal (4-ONE)...
  41. ncbi Monoterpenic aldehydes as potential anti-Leishmania agents: activity of Cymbopogon citratus and citral on L. infantum, L. tropica and L. major
    M Machado
    Faculdade de Farmácia CEF, Universidade de Coimbra, Azinhaga de Santa Comba, 3030 548 Coimbra, Portugal
    Exp Parasitol 130:223-31. 2012
    ..Taken together, ours findings lead us to propose that citral was responsible for anti-Leishmania activity of the C. citratus and both may represent a valuable source for therapeutic control of leishmaniasis...
  42. pmc Conversion of fatty aldehydes to alka(e)nes and formate by a cyanobacterial aldehyde decarbonylase: cryptic redox by an unusual dimetal oxygenase
    Ning Li
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Am Chem Soc 133:6158-61. 2011
    Cyanobacterial aldehyde decarbonylase (AD) catalyzes conversion of fatty aldehydes (R-CHO) to alka(e)nes (R-H) and formate...
  43. pmc Reactive oxygen species and alpha,beta-unsaturated aldehydes as second messengers in signal transduction
    Henry Jay Forman
    School of Natural Sciences, University of California, Merced, California, USA
    Ann N Y Acad Sci 1203:35-44. 2010
    Signaling by H(2)O(2), alpha,beta-unsaturated aldehydes, such as 4-hydroxy-2-nonenal (HNE) and related chemical species, is thought to differ from signaling by other second messengers because the oxidants and other electrophiles can ..
  44. ncbi Residue-specific adduction of tubulin by 4-hydroxynonenal and 4-oxononenal causes cross-linking and inhibits polymerization
    Benjamin J Stewart
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Chem Res Toxicol 20:1111-9. 2007
    The modification of proteins by lipid aldehydes produced in cells undergoing oxidative stress has been proposed as an important event that contributes to the pathology of numerous diseases...
  45. pmc Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells
    Colin T Shearn
    University of Colorado Denver, School of Pharmacy, Department of Pharmaceutical Sciences, 12850 East Montview Blvd, Box C238, Building V20, Room 2131, Aurora, CO 80045, USA
    Free Radic Biol Med 53:1-11. 2012
    ..The ability of 4-HNE to exert combinatorial effects on Erk, Jnk, and Akt-dependent cell survival pathways provides additional insight into the mechanisms of cellular damage associated with chronic inflammation...
  46. ncbi Overexpression of aldehyde dehydrogenase-2 attenuates neurotoxicity induced by 4-hydroxynonenal in cultured primary hippocampal neurons
    Jing Bai
    Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Neurotox Res 19:412-22. 2011
    ..Based on these findings, ALDH2 gene can be a potential therapeutic target for treatment of neurodegenerative diseases, such as AD...
  47. ncbi Lysis of cyanobacteria with volatile organic compounds
    Keiko Ozaki
    Graduate School of Environmental and Human Science, Meijo University, Tempaku, Nagoya 468 8503, Japan
    Chemosphere 71:1531-8. 2008
    ..This color change is similar to the phenomenon observed when a sudden decline in growth of cyanobacteria begins in a natural environment...
  48. ncbi Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease
    Massimo Corradi
    National Institute of Occupational Safety and Prevention Research Center, Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Italy
    Am J Respir Crit Care Med 167:1380-6. 2003
    The aims of the present study were (1) to evaluate whether individual aldehydes resulting from lipid peroxidation can be measured in exhaled breath condensate, (2) to assess the influence of sampling procedures on aldehyde concentrations,..
  49. ncbi Role of hydroperoxide lyase in white-backed planthopper (Sogatella furcifera Horváth)-induced resistance to bacterial blight in rice, Oryza sativa L
    Kenji Gomi
    National Institute of Agrobiological Sciences, NIAS, Tsukuba, Ibaraki 305 8602, Japan
    Plant J 61:46-57. 2010
    ..OsHPL2-overexpressing transgenic rice plants exhibited increased resistance to bacterial blight. Based on these data, we conclude that OsHPL2 and its derived (E)-2-hexenal play some role in WBPH-induced resistance in rice...
  50. ncbi Basic aspects of the biochemical reactivity of 4-hydroxynonenal
    R J Schaur
    Institute of Molecular Biology, Biochemistry and Microbiology, University of Graz, Schubertstrasse 1, 8010 Graz, Austria
    Mol Aspects Med 24:149-59. 2003
    ..Examples will be presented for the interaction of HNE with various classes of biomolecules such as proteins and peptides, lipids and nucleic acids and the biochemical consequences will be discussed...
  51. ncbi Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase
    David L Carbone
    Department of Pharmaceutical Sciences, School of Pharmacy, The University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Chem Res Toxicol 18:1324-31. 2005
    ..While some degree of sensitivity to these lipid aldehydes is suggested by the data, when compared to inactivation of other proteins by 4-HNE, PDI has demonstrated a ..
  52. pmc Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo
    Darren M Miller
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536 0509, USA
    Free Radic Biol Med 57:1-9. 2013
    ..Ongoing studies will determine the therapeutic efficacy of Nrf2-ARE activators to attenuate traumatic brain injury-induced pathophysiology...
  53. ncbi High plasticity in the production of diatom-derived polyunsaturated aldehydes under nutrient limitation: physiological and ecological implications
    Francois Ribalet
    Stazione Zoologica Anton Dohrn, Villa Comunale, I 80121 Napoli, Italy
    Protist 160:444-51. 2009
    ..These microalgae also produce chemical compounds such as polyunsaturated aldehydes (PUAs) that can potentially impair recruitment and cause malformations in the offspring of such grazers...
  54. ncbi Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal
    Jonathan A Doorn
    Department of Pharmacology, School of Medicine, The University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chem Biol Interact 143:93-100. 2003
    Peroxidation of polyunsaturated fatty acids yields the lipid aldehydes 4-hydroxynonenal (4HNE) and 4-oxononenal (4ONE). Adduction of proteins by 4HNE is thought to be involved in the pathogenesis of several diseases...
  55. pmc Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation
    Claus Schneider
    Department of Pharmacology and the Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 283:15539-43. 2008
    ..over the last 2 decades, understanding of the chemical mechanism of formation of 4-hydroxynonenal and related aldehydes has advanced much less...
  56. ncbi Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes
    Jose Manuel Perez
    Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170019, Chile
    J Biol Chem 283:7346-53. 2008
    ..Increased tolerance was also observed for the lipid peroxidation-derived aldehydes butanaldehyde, propanaldehyde, acrolein, and malondialdehyde and the membrane-peroxidizing compound tert-..
  57. ncbi Protected by fumigants: beetle perfumes in antimicrobial defense
    Jürgen Gross
    Institute of Phytopathology and Applied Zoology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, Giessen, Germany
    J Chem Ecol 34:179-88. 2008
  58. ncbi 4-Hydroxynonenal in the pathomechanisms of oxidative stress
    G Poli
    Department of Clinical and Biological Sciences of the University of Torino, S Luigi Hospital, Orbassano, Italy
    IUBMB Life 50:315-21. 2000
    ..Finally, on the basis of the already achieved evidence, pursuing investigation of the role of HNE in signal transduction and gene expression seems very promising...
  59. ncbi 4-hydroxynonenal induces apoptosis, NF-kappaB-activation and formation of 8-isoprostane in vascular smooth muscle cells
    J Ruef
    Division of Cardiology, University of Heidelberg, Germany
    Basic Res Cardiol 96:143-50. 2001
    ..2-fold increase) and the combined aldehydes HNE and malonaldehyde (1.5 micromol/L, 2.5-fold increase), (p < 0.05, resp)...
  60. ncbi Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy-2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells
    Dehe Kong
    Exonhit Inc, Gaithersburg, MD 20877, USA
    J Mol Neurosci 47:595-603. 2012
    ..Aldehyde dehydrogenases (ALDHs) are involved in metabolizing HNE and other endogenous aldehydes. Interestingly, the cytosolic aldehyde dehydrogenase 1A1 (ALDH1A1) has been reported to be down-regulated in ..
  61. ncbi Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: possible links between diabetes and atherosclerosis
    Fatemeh Moheimani
    Free Radical Group, The Heart Research Institute, 7 Eliza Street, Newtown NSW, 2042 Australia
    Biochim Biophys Acta 1802:561-71. 2010
    ..Reactions of glucose, or aldehydes derived from glucose (e.g...
  62. pmc Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE
    Jianbin Chen
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Invest Ophthalmol Vis Sci 50:936-42. 2009
    ..The purpose of the present study was to investigate how NF-E2-related factor-2 (Nrf2) and phosphatidylinositol 3 (PI3K) pathways affect the responses of cultured human retinal pigment epithelial (RPE) cells to 4-HNE...
  63. ncbi Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cells
    Peter V Usatyuk
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 279:11789-97. 2004
    ..These results suggest that the activation of ERK, JNK, and p38 MAP kinases is involved in 4-HNE-mediated actin remodeling and endothelial barrier function...
  64. ncbi 5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase
    Mi R Yun
    MRC for Ischemic Tissue Regeneration, Pusan National University, Busan, Korea
    Free Radic Res 44:742-50. 2010
    ..Altogether, these results suggest that 5-LO plays a critical role in HNE-induced ROS generation in murine macrophages through activation of NADPH oxidase...
  65. pmc Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
    Giorgia Volpi
    Department of Pharmacology, Chiesi Farmaceutici s p a, Parma, Italy
    Br J Pharmacol 163:649-61. 2011
    ..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells...
  66. pmc A better anti-diabetic recombinant human fibroblast growth factor 21 (rhFGF21) modified with polyethylene glycol
    Zhifeng Huang
    School of Pharmacy and Chinese American Research Institute for Diabetic Complications, Wenzhou Medical College, Wenzhou, Zhejiang, China
    PLoS ONE 6:e20669. 2011
    ..Therefore, the PEGylated rhFGF21 may be potentially applied in clinics to improve the metabolic syndrome for type 2 diabetic patients...
  67. ncbi 4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells
    Eun Hui Bae
    Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea
    Nephrol Dial Transplant 26:3866-73. 2011
    ..The present study was aimed to investigate the effects of HHE on renal tubular epithelial cells and its signaling mechanisms...
  68. pmc High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes
    Jarrod B French
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 49:8803-12. 2010
    ..These data provide structural evidence of several proposed reaction intermediates and allow for a more complete understanding of the catalytic mechanism of this enzyme...
  69. pmc Exploring the biology of lipid peroxidation-derived protein carbonylation
    Kristofer S Fritz
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
    Chem Res Toxicol 24:1411-9. 2011
    ..The accumulation of reactive aldehydes resulting from sustained oxidative stress and lipid peroxidation is an underlying factor in the development of ..
  70. ncbi Mating-induced differential coding of plant odour and sex pheromone in a male moth
    Romina B Barrozo
    INRA, UMR 1272 Physiologie de l Insecte Signalisation et Communication, Route de St Cyr, 78000 Versailles, France
    Eur J Neurosci 33:1841-50. 2011
  71. ncbi Upregulation of heme oxygenase-1 as an adaptive mechanism for protection against crotonaldehyde in human umbilical vein endothelial cells
    Seung Eun Lee
    Department of Microbiology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
    Toxicol Lett 201:240-8. 2011
    ..Taken together, our results demonstrated that crotonaldehyde-induced HO-1 expression is mediated by the PKC-δ-p38 MAPK-Nrf2-HO-1 pathway in HUVECs, which is an adaptive response to oxidative stress...
  72. pmc Relating protein adduction to gene expression changes: a systems approach
    Bing Zhang
    Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mol Biosyst 7:2118-27. 2011
    ..Although developed for analyzing protein adduction data, the framework can be easily adapted for phosphoproteomics and other types of protein modification data...
  73. ncbi Switching attraction to inhibition: mating-induced reversed role of sex pheromone in an insect
    Romina B Barrozo
    INRA, UMR 1272 Physiologie de l Insecte Signalisation et Communication, Route de St Cyr, F 78000 Versailles, France
    J Exp Biol 213:2933-9. 2010
  74. ncbi 4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases
    Giuseppe Poli
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043 Orbassano, Turin, Italy
    Mol Aspects Med 29:67-71. 2008
    ..In addition, the demonstrated adduction reaction of HNE with important signalling proteins strongly suggests a pathogenetic role for this lipid aldehyde in the progression of liver diseases...
  75. ncbi The coding of odour-intensity in the honeybee antennal lobe: local computation optimizes odour representation
    Silke Sachse
    Institut für Biologie Neurobiologie, Freie Universitat Berlin, Königin Luise Str 28 30, 14195 Berlin, Germany
    Eur J Neurosci 18:2119-32. 2003
  76. pmc Teratogenic effects of diatom metabolites on sea urchin Paracentrotus lividus embryos
    Giovanna Romano
    Stazione Zoologica Anton Dohrn, Villa comunale 80121 Napoli, Italy
    Mar Drugs 8:950-67. 2010
    The diatom-derived polyunsaturated aldehydes (PUAs), 2-trans,4-trans-decadienal, 2-trans,4-trans-octadienal, 2-trans,4-trans,7-octatrienal, 2-trans,4-trans-heptadienal, as well as tridecanal were tested on early and later larval ..
  77. ncbi Reactions of 4-hydroxynonenal with proteins and cellular targets
    Dennis R Petersen
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Free Radic Biol Med 37:937-45. 2004
    ..g., alcohol-induced liver disease); however, the precise mechanism(s) is currently unknown but likely results from adduction of proteins involved in cellular homeostasis or biological signaling...
  78. ncbi Growth inhibition of cultured marine phytoplankton by toxic algal-derived polyunsaturated aldehydes
    Francois Ribalet
    Stazione Zoologica Anton Dohrn di Napoli, Villa Comunale, I80121 Napoli, Italy
    Aquat Toxicol 85:219-27. 2007
    Several marine diatoms produce polyunsaturated aldehydes (PUAs) that have been shown to be toxic to a wide variety of model organisms, from bacteria to invertebrates...
  79. ncbi Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 90:261-6. 2010
    ..Via these mechanisms, lipid peroxidation products may induce lysosomal dysfunction and lipofuscinogenesis in the aging RPE and thus contribute to the pathogenesis of AMD...
  80. ncbi The proteasomal system and HNE-modified proteins
    Tilman Grune
    Neuroscience Research Center, Medical Faculty Charité, Humboldt University, Schumannstrasse 20 21, 10117 Berlin, Germany
    Mol Aspects Med 24:195-204. 2003
    ..process of lipid peroxidation, several reactive low-molecular weight products are formed, including reactive aldehydes as 4-hydroxynonenal (HNE). These aldehydic lipid peroxidation products in turn are able to modify proteins...
  81. ncbi Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis
    Peeter Karihtala
    Departments of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Histopathology 58:854-62. 2011
  82. ncbi Comparative study of sex pheromone composition and biosynthesis in Helicoverpa armigera, H. assulta and their hybrid
    Hong lei Wang
    State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Insect Biochem Mol Biol 35:575-83. 2005
    ..armigera. The evolutionary relationships between the desaturases in several Helicoverpa species are also discussed in this paper...
  83. ncbi 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia
    E McKracken
    Wellcome Surgical Institute and Hugh Fraser Neuroscience Laboratories, University of Glasgow, United Kingdom
    Brain Pathol 11:414-21. 2001
    ..This substantiates a role for lipid peroxidation in the pathogenesis of cerebral ischemia. There was no indication that APOE genotype influenced the extent of 4-HNE immunoreactivity...
  84. ncbi Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins
    Peter V Usatyuk
    Section of Pulmonary and Critical Care Medicine, Division of Biological Sciences, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:35554-66. 2006
    4-Hydroxy-2-nonenal (4-HNE), one of the major biologically active aldehydes formed during inflammation and oxidative stress, has been implicated in a number of cardiovascular and pulmonary disorders...
  85. ncbi Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury
    Arun K Thukkani
    Dept of Biochemistry and Molecular Biology, St Louis Univ School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Am J Physiol Heart Circ Physiol 288:H2955-64. 2005
    ..targeted by neutrophil-derived reactive chlorinating species that lead to the production of alpha-chloro fatty aldehydes. Results herein demonstrate that the alpha-chloro fatty aldehyde 2-chlorohexadecanal (2-ClHDA) accumulates in ..
  86. ncbi Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion
    A L Bulteau
    Departments of Biochemistry and Biology, , 75251 Paris Cedex 05, France
    J Biol Chem 276:30057-63. 2001
    ..Taken together, our findings provide insight into potential mechanisms of coronary occlusion/reperfusion-induced proteasome inactivation and cellular consequences of these events...
  87. ncbi Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease
    Tanea Reed
    Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Dis 30:107-20. 2008
    ..We suggest that impairment of target proteins through the production of HNE adducts leads to protein dysfunction and eventually neuronal death, thus contributing to the biological events that may lead MCI patients to progress to AD...
  88. pmc Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal
    Simona G Codreanu
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Proteomics 8:670-80. 2009
    ..Global analyses of protein lipid electrophile adducts provide a systems-level perspective on the mechanisms of diseases involving oxidative stress...
  89. pmc Mitochondrial aldehyde dehydrogenase and cardiac diseases
    Che Hong Chen
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cardiovasc Res 88:51-7. 2010
    Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes that cause cell damage and contribute to cardiac diseases...
  90. ncbi Green-leaf-derived C6-aroma compounds with potent antibacterial action that act on both Gram-negative and Gram-positive bacteria
    Soichiro Nakamura
    Department of Life and Environmental Sciences, Shimane University, Shimane 690 8550
    J Agric Food Chem 50:7639-44. 2002
    ..The bactericidal effects of 30 microg mL(-1) (3E)-hexenal were thoroughly maintained throughout periods of 2 days and 1 day against S. aureus IFO 12732 and E. coli IFO 3301, respectively, by a complex formation with alpha-cyclodextrin...
  91. ncbi Cuticular lipids of the booklouse, Liposcelis bostrychophila: hydrocarbons, aldehydes, fatty acids, and fatty acid amides
    Ralph W Howard
    USDA ARS, GMPRC, 1515 College Avenue, Manhattan, KS 66502, USA
    J Chem Ecol 29:615-27. 2003 the amides, free fatty acids (C16:1, C16:0, C18:2, C18:1, and C18:0 in chain length) and three straight chain aldehydes (C15, C16, and C17:1 in chain length) also occurred as cuticular components...
  92. ncbi Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions
    Angel Catala
    Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas INIFTA CCT La Plata CONICET, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CC 16, Sucursal 4, 1900 La Plata, Argentina
    Chem Phys Lipids 157:1-11. 2009
    ..Compared to free radicals, these aldehydes are relatively stable and can diffuse within or even escape from the cell and attack targets far from the site ..
  93. ncbi Measurement of lipid peroxidation
    K Moore
    Department of Medicine, Royal Free Hospital School of Medicine, London, UK
    Free Radic Res 28:659-71. 1998
    ..results in the formation of conjugated dienes, lipid hydroperoxides and degradation products such as alkanes, aldehydes and isoprostanes...
  94. ncbi Volatile C6-aldehydes and Allo-ocimene activate defense genes and induce resistance against Botrytis cinerea in Arabidopsis thaliana
    Kyutaro Kishimoto
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Kawaguchi, Saitama, 332 0012 Japan
    Plant Cell Physiol 46:1093-102. 2005
    ..When Botrytis cinerea was inoculated after the volatile treatment, retardation of disease development could be seen. It appears that volatile treatment could make the plants more resistant against the fungal disease...
  95. ncbi Tuning and topography in an odor map on the rat olfactory bulb
    M Meister
    Harvard University, Cambridge, Massachusetts 02138, and Max Planck Institute of Neurobiology, D 82152 Munich Martinsried, Germany
    J Neurosci 21:1351-60. 2001
    ..We explore several parallels to the function and architecture of the visual system that help interpret the neural representation of odors...
  96. ncbi Regulation of constitutive neutrophil apoptosis by the alpha,beta-unsaturated aldehydes acrolein and 4-hydroxynonenal
    Erik I Finkelstein
    Dept of Pathology, College of Medicine, University of Vermont, 89 Beaumont Ave Burlington, VT 05405, USA
    Am J Physiol Lung Cell Mol Physiol 289:L1019-28. 2005
    Reactive alpha,beta-unsaturated aldehydes are major components of common environmental pollutants and are products of lipid oxidation...
  97. ncbi Lipid peroxidation: physiological levels and dual biological effects
    Etsuo Niki
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 47:469-84. 2009
    ..Even such unregulated LPO products may exert beneficial effects at low levels, but excessive unregulated LPO may lead to pathological disorders and diseases...
  98. ncbi C6-volatiles derived from the lipoxygenase pathway induce a subset of defense-related genes
    N J Bate
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Plant J 16:561-9. 1998
    Six-Carbon (C6-) volatiles, including the aldehydes trans-2-hexenal, hexanal and cis-3-hexenal, as well as their corresponding alcohols, are produced from damaged or wounded plant tissue as a product of the enzymatic activity of ..
  99. pmc Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxi
    Olga V Belyaeva
    Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, 35294, USA
    Biochemistry 44:7035-47. 2005
    ..NADP(+) and NADPH than for NAD(+) and NADH and recognizes both retinoids and lipid peroxidation products (C(9) aldehydes) as substrates...
  100. ncbi Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells
    Haider Raza
    Department of Biochemistry, Faculty of Medicine and Health Sciences, UAE University, POBox 17666, Al Ain, United Arab Emirates
    Toxicol Appl Pharmacol 226:161-8. 2008
    ..The alterations in mitochondrial energy metabolism and redox functions may therefore be critical in determining the difference between cell death and survival...
  101. ncbi Cytotoxicity of diatom-derived oxylipins in organisms belonging to different phyla
    Sven Adolph
    Max Planck Institute, Hans Knöll Str 8, D 07745 Jena, Germany
    J Exp Biol 207:2935-46. 2004
    The cytotoxicity of several saturated and unsaturated marine diatom-derived aldehydes and an oxo-acid have been screened in vitro and in vivo against different organisms, such as bacteria, algae, fungi, echinoderms, molluscs and ..

Research Grants65

  1. Stereochemistry of Elimination and Proton Transfer
    JERRY MOHRIG; Fiscal Year: 2002
    ..addition and elimination reactions involving n-substituted esters and thioesters of butyric acid and the related aldehydes and ketones...
  2. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..The role of lipid aldehydes and their metabolism on the susceptibility of epithelial target cells to CIN will be evaluated. The ability of E...
  3. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..dust, elemental carbon, black carbon, nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), aldehydes, and polycyclic aromatic hydrocarbons (PAHs) will be sampled from the mine...
  4. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..Public Health Relevance: Acrolein is one of the major reactive aldehydes ubiquitously present in foods, water and in the environment. It is a major constituent of cigarette smoke...
  5. Role of Glutathione S-Transferase P in Heart Failure
    Sumanth D Prabhu; Fiscal Year: 2013
    ..However, ROS also generate secondary intermediates derived from lipid peroxidation, including peroxides and aldehydes that amplify oxidative injury...
  6. Role of ALDH7A1 in Ethanol-Induced Oxidative Damage
    CHAD NICHOLAS BROCKER; Fiscal Year: 2011
    ..of polyunsaturated fatty acids in cell membranes via LPO generates over two hundred different types of reactive aldehydes. These molecules bind to protein, DNA and other compounds within cells causing enzyme inactivation, DNA damage ..
  7. Contribution of Gstm1 to the severity of hypertension and chronic kidney disease
    Thu H Le; Fiscal Year: 2013
    ..that metabolize xenobiotics and a broad range of reactive oxygen species (ROS), and the highly reactive aldehydes (RAs) that are end products of lipid peroxidation...
  8. Atherogenic mechanism of lipid peroxidation-derived aldehydes
    Sanjay Srivastava; Fiscal Year: 2013 applicant): The overall goal of this project is to understand the role of lipid peroxidation-derived aldehydes in atherosclerosis...
  9. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..LPO generates a variety of aldehydes, such as acrolein (Acr), crotonaldehyde, malondialdehyde (MDA), and trans-4-hydroxy- 2-nonenal (4-HNE), that are ..
  10. Hyperglycemia-induced DNA damage as a driver of genomic instability
    JOHN S TERMINI; Fiscal Year: 2013
    ..accumulation of advanced glycation end products (AGEs) resulting from reactions of glucose-derived ?-oxo aldehydes with proteins, lipids, and DNA...
    Oscar A Bizzozero; Fiscal Year: 2012
    ..A major consequence of ROS accumulation is the non-enzymatic introduction of aldehydes or ketones into specific amino acid residues of proteins (i.e. carbonylation)...
  12. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..the main thiol-reactive agents within CS are acrolein (2,3- propenal) and other related unsaturated aldehydes. Our recent studies in mice have demonstrated immunosuppressive effects of acrolein on alveolar macrophages that ..
  13. Role of Mitochondrial Aldehyde Dehydrogenases in Ethanol Metabolism and Toxicity
    Vasilis Vasiliou; Fiscal Year: 2010 a functional enzyme that protects cells by metabolizing acetaldehyde and lipid peroxidation-associated aldehydes. Second, we hypothesize that ALDH2*2 protein may inactivate other ALDHs by interacting with them...
  14. Cardioprotective Mechanisms of Glutathione S-transferase P
    DANIEL JOSEPH CONKLIN; Fiscal Year: 2012
    ..contribution of GSTP to cardiac protection during I/R in situ (Aim 1), metabolism of lipid peroxidation- derived aldehydes (acrolein and 4-hydroxy-trans-2-nonenal;HNE), which are the preferred endogenous substrates of this enzyme (Aim ..
  15. Chemoprevention of Colorectal Cancer by Aldose Reductase Inhibition
    Satish K Srivastava; Fiscal Year: 2013
    ..AR), an enzyme that catalyzes the reduction of reactive oxygen species-induced lipid peroxidation-derived lipid aldehydes and their glutathione (GSH)- conjugates (GS-LDAs), is an essential mediator of oxidative stress-induced ..
  16. Oxidative Stress and Autoimmunity
    M Firoze Khan; Fiscal Year: 2013
    ..Our long-term goal is to elucidate the role of lipid peroxidation-derived aldehydes (LPDAs) and reactive nitrogen species (RNS) in the development of ADs induced and/or exacerbated by chemical ..
  17. Aldose Reductase: A Regulator of Inflammatory Signals
    KOTA VENKATA RAMANA; Fiscal Year: 2011
    ..aldose reductase (AR), plays a pivotal rote in the detoxification of lipid peroxidation-generated lipid derived aldehydes (LDAs) and their conjugates with GSH...
  18. Tobacco Products and Atherosclerotic Disease
    Sanjay Srivastava; Fiscal Year: 2013
    ..intensities of tobacco smoke and smokeless tobacco, we will identify urinary metabolites of exposure-derived aldehydes and determine how they relate to the extent and duration of exposure as well as to atherosclerotic lesion ..
  19. Aldehydes in Alcohol-Induced Organ Injury
    Zhanxiang Zhou; Fiscal Year: 2013
    ..While alcohol metabolism generates acetaldehyde, lipid peroxidation produces lipid aldehydes such as 4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)...
  20. Differential Redox &Electrophilic Toxicities of Modified Tobacco Products
    Norbert Staimer; Fiscal Year: 2013
    ..Conjugated ketones, such as unsaturated ?,?-aldehydes and quinones are of toxicological importance because they promote oxidative stress and eventually lead to ..
  21. Detoxification of Biogeneic Aldehydes in Parkinson's Disease
    Randy Strong; Fiscal Year: 2013
    ..These aldehydes or their metabolites can form adducts with a-synuclein, leading to formation of toxic fibrils and eventually ..
  22. Defining Molecular Determinants of Type 2 Diabetes Using Quantitative Proteomics
    Paul A Grimsrud; Fiscal Year: 2013
    ..phosphorylation of mitochondrial redox enzymes in regulating the abundance of bioactive lipophilic aldehydes. I will test the hypothesis that obesity-induced phosphorylation of dehydrogenase/reductase SDR family member 4 (..
  23. TRPA1 Channels in Sensory Neurons as Targets for Environmental Irritants
    Sven Eric Jordt; Fiscal Year: 2012, eyes and mucous membranes are activated by environmental toxicants, including the alpha, beta-unsaturated aldehydes. Aldehydes such as acrolein (2-propenal) are severely irritating volatile compounds present in cigarette smoke, ..
  24. Toxicity and Detoxification of 4 Hydroxyalkenals in Heart
    ..We propose that modification of myocardial proteins by these aldehydes is a significant source of cardiac injury and dysfunction induced by chronic hemodynamic stress and therefore, ..
  25. Activation and Inhibition of Aldehyde Dehydrogenase 2
    Thomas D Hurley; Fiscal Year: 2013
    ..participates in multiple metabolic pathways in humans, including the metabolism of endogenous and biogenic aldehydes, most notably acetaldehyde during ethanol metabolism, and as the bioactivator of nitroglycerin...
  26. PGP, A Possible Biomarker for COPD Exacerbations and or Progression
    J Edwin Blalock; Fiscal Year: 2013
    ..We believe this persistence is driven by endogenously produced reactive aldehydes, such as acrolein and acetaldehyde, which can acetylate PGP as well as inactivate the aminopeptidase but not ..
    Daria Mochly-Rosen; Fiscal Year: 2013 have a variety of chronic diseases associated with oxidative stress and the resulting accumulation of toxic aldehydes, including myocardial infarction...
  28. Detoxification of Xenobiotics in Ocular Tissue
    YOGESH CHANDRA AWASTHI; Fiscal Year: 2010
    Toxic lipid aldehydes such as 4-hydroxynonenal (HNE), formed during lipid peroxidation (LPO), are involved in the etiology of cataractogenesis and age related pathophysiology of ocular tissues...
  29. Localized Metal Modulation as a First Line Treatment of Burn Injuries
    JERRY GIN; Fiscal Year: 2012
    ..early on in burns cause increased lipid peroxidation and iron dependent formation of cytotoxic lipid aldehydes, such as 4- hydroxynonenal (HNE) that can induce Ca/Fe-dependent toxic events...
  30. Role of Aldose Reductase in Diabetic Complications
    Satish K Srivastava; Fiscal Year: 2013
    ..Our results during the current funding period show that AR-catalyzed reduced products of lipid aldehydes-glutathione conjugates (such as GS-DHN, glutathione dihydroxynonane), formed under hyperglycemia-induced ..
  31. Metabolic Imaging of the Cardioprotective Effects of Alcohol and ALDH2 Activators
    Daniel M Spielman; Fiscal Year: 2013
    ..ultimately activating aldehyde dehydrogenase (ALDH2), the major mitochondrial enzyme for removing toxic aldehydes arising from oxidative stress...
  32. The Nerve Terminal as the Site of Action for Type-2 Alkenes
    ..In addition, unsaturated aldehydes such as acrolein and HNE are produced during membrane lipid peroxidation associated with cellular oxidative ..
  33. Role and Molecular Mechanisms of Corneal Aldehyde Dehydrogenase
    Vasilis Vasiliou; Fiscal Year: 2013
    ..UVR induces reactive oxygen species (ROS) that leads to membrane lipid peroxidation and accumulation of toxic aldehydes, such as 4-hydroxy-2- nonenal (4-HNE)...
  34. Mouse Models for Alcohol Metabolism and Tissue Injury
    Vasilis Vasiliou; Fiscal Year: 2013
    ..In addition, the accumulation of ethanol-derived aldehydes and hydroxyethyl radical serves to modify critical biological functions by forming adducts with proteins and DNA...
  35. Organochlorine-Mediated Generation of a Dopamine Derived Neurotoxin
    Jonathan A Doorn; Fiscal Year: 2012
    ..b>Aldehydes generated via oxidative stress, e.g...
  36. Metabolite Initiated Protein Misfolding and Amyloidosis
    Jeffery W Kelly; Fiscal Year: 2013
    ..Past studies have demonstrated that hydrophobic aldehydes derived from oxidative stress, in particular 4-hydroxynonenal and the atheronals, exacerbate aggregation through ..
  37. A Better High-level Disinfectant for Endoscopes and Other Medical Equipments/Devi
    Neera Satsangi; Fiscal Year: 2012
    ..will (1) limit personnel exposure to the ingredients of common commercial HLD products, such as the vapors of aldehydes, peracids, etc...
  38. Mass Spectrometric Studies of Protein Oxidation: Aging and Environmental Factors
    Scott Gronert; Fiscal Year: 2013
    ..e., unsaturated aldehydes) and analyzed with a sensitive mass spectrometric approach...
  39. Targeting protein adduction by reactive aldehydes in Alzheimer's disease
    Olivier Boutaud; Fiscal Year: 2013
    ..Although these phenomena are complex, they generate a common molecular species of reactive keto-aldehydes. These reactive aldehydes are produced as a result of either lipid peroxidation associated with oxidative stress ..
  40. Airway Injury Caused by MAA Adducts
    Todd A Wyatt; Fiscal Year: 2012
    ..Accumulation of lung aldehydes results in formation of hybrid aldehyde adducted proteins that produce pro-inflammatory effects parallel to ..
  41. Modifications of L-FABP by Reactive Aldehydes in a Model of Chronic ALD
    REBECCA LEANNE SMATHERS; Fiscal Year: 2011
    ..The data provided by this application will provide further insight into the mechanisms involving 4-HNE and 4-ONE toxicity, and the effects they have on lipid homeostasis in early ALD. ..
  42. Mechanisms For Estrogen-Dependent Myocardial Depressant Effect Of Ethanol
    Abdel A Abdel-Rahman; Fiscal Year: 2013
    ..competition of higher ACA level with more cytotoxic substrates for mit-ALDH2 leads to accumulation of cytotoxic aldehydes (oxidative stress and myocardial dysfunction)...
  43. Role of human DNA polymerase kappa in replicative bypass of DNA lesions
    Satya Prakash; Fiscal Year: 2013
    ..bulky trans-4-hydroxy-2-non-enal- deoxyguanosine (HNE-dG) adducts that result from the reaction of N2-dG with aldehydes or enals generated from free radical attack on lipids in membranes;and the multi-cyclic benzo[a]pyrene 7,8-diol ..
    Douglas L Rosene; Fiscal Year: 2013
    ..cohort of 6 middle aged monkeys will be treated like cohort 1 except they will be perfusion fixed with mixed aldehydes for electron microscopy to supplement existing samples and allow identification of the ultrastructural changes ..
  45. Protein Glycation and the Proteasome: Role in Neurological Diseases and Aging
    PAMELA ANNE MAHER; Fiscal Year: 2013
    ..MG is one of the major reactive aldehydes responsible for AGE formation...
  46. Modification of PDI by 4-HNE and 4-ONE and its Role in Ethanol-Induced ER Stress
    James J Galligan; Fiscal Year: 2011
    ..Through the adduction of active site cysteines, these aldehydes have been shown to cause alterations in the enzymatic activity of numerous proteins...
  47. Enantioselective Synthesis of Phosphinate Derivatives
    John Cong Gui Zhao; Fiscal Year: 2012
    ..reaction of 1-ketophosphinic acid derivatives (or 1-iminophosphinic acid derivatives) and ketones/enolizable aldehydes for the enantioselective synthesis of 1-hydroxy (or amino) phosphinic acid derivatives...
    Yong Wang; Fiscal Year: 2010
    ..thus significantly enhancing the collage biostability and mechanical strength;3) Hydrolytic deprotection of aldehydes yields hydrophilic resin branches, which facilitate resin permeation to hydrated collagen and produces no ..
  49. Developing the Synthetic Utility of the Copper-Catalyzed Diboration of Aldehydes
    Timothy B Clark; Fiscal Year: 2010
    ..proposed research involves the development of synthetic methods that utilizes the copper-catalyzed diboration of aldehydes, ketones, and imines...
  50. Bioinspired Enantioselective Catalytic alpha-Alkylation of Aldehydes
    SEAN M KEDROWSKI; Fiscal Year: 2013
    ..small molecule amino-arene catalyst that accomplishes the direct, enantioselective, catalytic ?-alkylation of aldehydes using cationic sulfur-based alkylating agents like SAM...
  51. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..mass spectrometry (LC-MS/MS) will be used as a complementary approach to develop biomarkers of effect (aldehydes from lipid peroxidation) suitable for the long-term monitoring of COPD patients...
  52. Synthesis of Chiral Organofluorines via Catalytic Asymmetric C-C Bond Formation w
    Christian Wolf; Fiscal Year: 2013
    ..with ample preliminary results obtained by a copper-bisoxazoline catalyzed reaction using aliphatic and aromatic aldehydes. Continued ligand development and the planned mechanistic investigations will further improve the ..
  53. Enantioselective Thiourea-Catalyzed Syntheses of beta-Lactones and beta-Lactams
    PAMELA MICHELE TADROSS; Fiscal Year: 2013
    ..Specifically, the thiourea catalyst will mediate the formal [2+2] cycloaddition reaction between ketenes and aldehydes, ketones, and imines...
  54. University of Louisville Bioinformatics Faculty Recruitment for Epigenetics
    Craig J McClain; Fiscal Year: 2010
    ..and Obesity Research (P20RR024489-01A1, Aruni Bhatnagar, PI);and Cardiovascular Toxicity of Environmental Aldehydes (P01ES011860-05, Aruni Bhatnagar, PI)...
  55. Chemical and Biological Studies of the Guadinomines
    AARON ELIJAH MAY; Fiscal Year: 2013
    ..We have shown that diamines react cleanly with fluorine-containing aldehydes to make aminals at room temperature without added catalysts (May, Khosla - unpublished results)...
  56. Involvement of Aldehydes in Alcohol Addiction
    William McBride; Fiscal Year: 2009
    ..Understanding the contribution of ACD and THIQs to high alcohol drinking could lead to the development of novel pharmaco-therapies for the treatment of alcoholism and alcohol abuse ..
    John Montgomery; Fiscal Year: 2013
    ..The expected impact of solving challenges in the regio- and enantioselective reductive union of aldehydes and alkynes will be the creation of a process that becomes widely adopted by synthetic chemists...
  58. Ichthyosis in Sjogren-Larsson Syndrome
    William B Rizzo; Fiscal Year: 2010
    ..mental retardation and spasticity, and are hypothesized to arise from the deranged metabolism of fatty aldehydes and precursor lipids such as fatty alcohols, which cannot be metabolized by FALDH...
  59. Development of Dynamic Combinatorial Libraries for Cruzipain Inhibition
    Peter Wipf; Fiscal Year: 2009
    ..and synthesis of new scaffolds to generate dynamic combinatorial libraries: (a) using pyrazolotriazinones and aldehydes as building blocks;(b) using new heterocyclic systems with aldehydes as building blocks. 2...
    Minor Coon; Fiscal Year: 2000
    ..Xenobiotic esters and amides that form aldehydes or other potentially toxic products will also be examined as possible substrates. 2...
  61. New Chiral Br??nsted Acids for Asymmetric Synthesis
    WILLIAM DEAN WULFF; Fiscal Year: 2013
    ..boroxinate catalyst in other reactions including the Darzens reaction, [3+2] cycloadditions, aminoallylation of aldehydes, and the Ugi reaction...
    MICHAEL CHAITIN; Fiscal Year: 1991
    ..Some of the tissue samples will be chemically fixed in aldehydes. Other samples will undergo physical fixation using slam freezing of the tissue against a polished copper ..
    Albert van Der Vliet; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Reactive aldehydes such as acrolein (2,3-propenal) are major components of air pollution and are proposed to contribute to the adverse effects of smoking in lung diseases such as chronic ..
  64. Total Synthesis of Cytotoxic ent-Kauranoid Natural Products
    DAVID JOHN MICHAELIS; Fiscal Year: 2012
    ..on the development of a novel vanadium-catalyzed cascade reaction between propargylic alcohols and cyclopropyl aldehydes that generates highly functionalized 1,3-dienes...
  65. Synergistic Catalysis for Chemical Synthesis
    DAVID W MACMILLAN; Fiscal Year: 2013
    ..organocatalysis and copper catalysis, of a collection of powerful new asymmetric methods, namely: -arylation of aldehydes;-vinylation of aldehydes using either vinyl iodonium salts or vinyl borane coupling partners;-methylation of ..