methanol

Summary

Summary: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.

Top Publications

  1. pmc Adaptation of Hansenula polymorpha to methanol: a transcriptome analysis
    Tim van Zutphen
    Molecular Cell Biology, University of Groningen, Haren, The Netherlands
    BMC Genomics 11:1. 2010
  2. pmc Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures
    Joel Jordà
    Departament d Enginyeria Quimica, Escola d Enginyeria, Universitat Autonoma de Barcelona, Bellaterra Cerdanyola del Valles, Spain
    Microb Cell Fact 11:57. 2012
  3. pmc Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources
    Stephane Vuilleumier
    Département Micro organismes, Génomes, Environnement, Universite de Strasbourg, UMR7156 CNRS, Strasbourg, France
    PLoS ONE 4:e5584. 2009
  4. pmc Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement
    Bevan Ks Chung
    NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, 05 01, 117456, Singapore
    Microb Cell Fact 9:50. 2010
  5. ncbi Expression of recombinant proteins in Pichia pastoris
    Pingzuo Li
    Shanghai Research Center of Biotechnology, Chinese Academy of Sciences, Shanghai, 200233, People s Republic of China
    Appl Biochem Biotechnol 142:105-24. 2007
  6. ncbi Methanol is an endogenous elicitor molecule for the synthesis of tryptophan and tryptophan-derived secondary metabolites upon senescence of detached rice leaves
    Kiyoon Kang
    Department of Biotechnology, Interdisciplinary Program of Graduate School for Bioenergy and Biomaterials, Bioenergy Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Plant J 66:247-57. 2011
  7. ncbi Templated photocatalytic synthesis of well-defined platinum hollow nanostructures with enhanced catalytic performance for methanol oxidation
    Feng Bai
    Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004, People s Republic of China
    Nano Lett 11:3759-62. 2011
  8. ncbi Pexophagy: the selective autophagy of peroxisomes
    William A Dunn
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida, USA
    Autophagy 1:75-83. 2005
  9. ncbi Identification of acetate- or methanol-assimilating bacteria under nitrate-reducing conditions by stable-isotope probing
    Toshifumi Osaka
    Department of Chemical Engineering, Waseda University, 3 4 1 Ohkubo, Shinjuku ku, Tokyo 169 8555, Japan
    Microb Ecol 52:253-66. 2006
  10. ncbi Caterpillar-elicited methanol emission: a new signal in plant-herbivore interactions?
    Caroline C von Dahl
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, 07745 Jena, Germany
    Plant J 46:948-60. 2006

Detail Information

Publications340 found, 100 shown here

  1. pmc Adaptation of Hansenula polymorpha to methanol: a transcriptome analysis
    Tim van Zutphen
    Molecular Cell Biology, University of Groningen, Haren, The Netherlands
    BMC Genomics 11:1. 2010
    Methylotrophic yeast species (e.g. Hansenula polymorpha, Pichia pastoris) can grow on methanol as sole source of carbon and energy...
  2. pmc Metabolic flux profiling of recombinant protein secreting Pichia pastoris growing on glucose:methanol mixtures
    Joel Jordà
    Departament d Enginyeria Quimica, Escola d Enginyeria, Universitat Autonoma de Barcelona, Bellaterra Cerdanyola del Valles, Spain
    Microb Cell Fact 11:57. 2012
    ..Mixed feeds of methanol and a multicarbon source instead of methanol as sole carbon source have been shown to improve product ..
  3. pmc Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources
    Stephane Vuilleumier
    Département Micro organismes, Génomes, Environnement, Universite de Strasbourg, UMR7156 CNRS, Strasbourg, France
    PLoS ONE 4:e5584. 2009
    ....
  4. pmc Genome-scale metabolic reconstruction and in silico analysis of methylotrophic yeast Pichia pastoris for strain improvement
    Bevan Ks Chung
    NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, 05 01, 117456, Singapore
    Microb Cell Fact 9:50. 2010
    ..pastoris can be employed together with high throughput experimental data analysis, for better understanding of the methylotrophic yeast's metabolism...
  5. ncbi Expression of recombinant proteins in Pichia pastoris
    Pingzuo Li
    Shanghai Research Center of Biotechnology, Chinese Academy of Sciences, Shanghai, 200233, People s Republic of China
    Appl Biochem Biotechnol 142:105-24. 2007
    ..Optimization can be achieved by controlling the medium composition, pH, temperature, and dissolved oxygen, as well as by methanol induction and feed mode.
  6. ncbi Methanol is an endogenous elicitor molecule for the synthesis of tryptophan and tryptophan-derived secondary metabolites upon senescence of detached rice leaves
    Kiyoon Kang
    Department of Biotechnology, Interdisciplinary Program of Graduate School for Bioenergy and Biomaterials, Bioenergy Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Plant J 66:247-57. 2011
    ..and Trp-derived secondary metabolites such as serotonin and 4-coumaroylserotonin accumulated in concert with methanol (MeOH) production...
  7. ncbi Templated photocatalytic synthesis of well-defined platinum hollow nanostructures with enhanced catalytic performance for methanol oxidation
    Feng Bai
    Key Laboratory for Special Functional Materials of the Ministry of Education, Henan University, Kaifeng 475004, People s Republic of China
    Nano Lett 11:3759-62. 2011
    ..These nanostructures possess interconnected nanoporous framework as shell with high surface area for enhanced catalytic performance/mass transport for methanol oxidation.
  8. ncbi Pexophagy: the selective autophagy of peroxisomes
    William A Dunn
    Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida, USA
    Autophagy 1:75-83. 2005
    Pichia pastoris and Hansenula polymorpha are methylotrophic yeasts capable of utilizing methanol, as a sole source of carbon and energy...
  9. ncbi Identification of acetate- or methanol-assimilating bacteria under nitrate-reducing conditions by stable-isotope probing
    Toshifumi Osaka
    Department of Chemical Engineering, Waseda University, 3 4 1 Ohkubo, Shinjuku ku, Tokyo 169 8555, Japan
    Microb Ecol 52:253-66. 2006
    Stable-isotope probing (SIP) was used to identify acetate- or methanol-assimilating bacteria under nitrate-reducing conditions in activated sludge...
  10. ncbi Caterpillar-elicited methanol emission: a new signal in plant-herbivore interactions?
    Caroline C von Dahl
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, 07745 Jena, Germany
    Plant J 46:948-60. 2006
    Plants release into the atmosphere large quantities of volatile organic compounds (VOCs), of which methanol (MeOH), a putative waste product, is the second most abundant...
  11. pmc Antioxidant activities and phenolic contents of the methanol extracts of the stems of Acokanthera oppositifolia and Adenia gummifera
    Adeolu A Adedapo
    Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria
    BMC Complement Altern Med 8:54. 2008
    ..Antioxidants thus play an important role of protecting the human body against damage by the free radicals. Plants containing phenolic compounds have been reported to possess strong antioxidant properties...
  12. ncbi Analysis of single-chain antibody production in Pichia pastoris using on-line methanol control in fed-batch and mixed-feed fermentations
    S Hellwig
    , RWTH Aachen, 52074 Aachen, Germany
    Biotechnol Bioeng 74:344-52. 2001
    ..In particular, the lack of on-line methanol analysis leads to fermentation protocols that may impair the optimal expression of the desired products...
  13. pmc Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics
    Rémi Peyraud
    Institute of Microbiology, Eidgenössiche Technische Hochschule Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:4846-51. 2009
    The assimilation of one-carbon (C1) compounds, such as methanol, by serine cycle methylotrophs requires the continuous regeneration of glyoxylate...
  14. ncbi Antiinflammatory activity of methanol extract isolated from stem bark of Magnolia kobus
    Jong Soon Kang
    Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk, Korea
    Phytother Res 22:883-8. 2008
    The present study reports the antiinflammatory activity of a methanol extract isolated from the stem bark of Magnolia kobus (MK)...
  15. ncbi Metabolic mechanisms of methanol/formaldehyde in isolated rat hepatocytes: carbonyl-metabolizing enzymes versus oxidative stress
    Stephanie L Macallister
    Department of Pharmaceutical Science, Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Chem Biol Interact 191:308-14. 2011
    b>Methanol (CH(3)OH), a common industrial solvent, is metabolized to toxic compounds by several enzymatic as well as free radical pathways...
  16. pmc Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
    Igor K Voukeng
    Department of Biochemistry, Faculty of Science, University of Dschang, P, O, Box 67, Dschang, Cameroon, Africa
    BMC Res Notes 5:299. 2012
    The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common ..
  17. pmc Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes
    Ana Leticia Vanz
    Technical Chemistry Life Science, Leibniz University of Hannover, Hannover, Germany
    Microb Cell Fact 11:103. 2012
    ..Most often, protein production is under the control of the strong methanol-inducible aox1 promoter. However, detailed information about the physiological alterations in P...
  18. ncbi Fatty acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids
    Mario Klingler
    Division of Metabolic and Nutritional Medicine, Dr von Hauner Children s Hospital, University of Munich Medical Center, Lindwurmstr 4, 80337, Munich, Germany
    Lipids 46:981-90. 2011
    ..The accuracy and reliability of this new method is comparable to conventional invasive methods for the determination of the n-3 fatty acid status in humans, and it is well applicable in interventional or epidemiological studies...
  19. ncbi A simple method to monitor and control methanol feeding of Pichia pastoris fermentations using mid-IR spectroscopy
    Jonas Schenk
    Laboratory of Chemical and Biochemical Engineering LGCB, Station 6 CH J2 503, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    J Biotechnol 128:344-53. 2007
    ..Fed-batch experiments at constant methanol (substrate) concentration ranging from 0.8 to 15gl(-1) were carried out...
  20. ncbi Consistent sets of spectrophotometric chlorophyll equations for acetone, methanol and ethanol solvents
    Raymond J Ritchie
    School of Biological Sciences, The University of Sydney, Sydney, NSW 2006, Australia
    Photosynth Res 89:27-41. 2006
    ..which uses Chl d as its primary photosynthetic pigment and also has Chl a, have been developed for 90% acetone, methanol and ethanol solvents...
  21. pmc Therapeutic photobiomodulation for methanol-induced retinal toxicity
    J T Eells
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 100:3439-44. 2003
    b>Methanol intoxication produces toxic injury to the retina and optic nerve, resulting in blindness...
  22. ncbi The quinoprotein dehydrogenases for methanol and glucose
    Christopher Anthony
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Arch Biochem Biophys 428:2-9. 2004
    ..These are the soluble methanol dehydrogenase and the membrane glucose dehydrogenase (mGDH)...
  23. ncbi Improved production of monoclonal antibodies through oxygen-limited cultivation of glycoengineered yeast
    Marina Berdichevsky
    Biologics New and Enabling Technologies, Merck and Co Inc, 126 E Lincoln Ave, Rahway, NJ 07065, United States
    J Biotechnol 155:217-24. 2011
    ..in glycoengineered Pichia pastoris is a non-linear function of specific growth rate that is dictated by a limited methanol feed rate...
  24. ncbi In vitro and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract
    Yanyan Yang
    Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea
    J Ethnopharmacol 139:616-25. 2012
    ..This study is therefore aimed at exploring the anti-inflammatory effects of 99% methanol extracts (Ph-ME) of this plant.
  25. ncbi Facultative methylotrophs from the human oral cavity and methylotrophy in strains of Gordonia, Leifsonia, and Microbacterium
    Wei Lian Hung
    King s College London Dental Institute, Microbiology, Guy s Campus, London, SE1 9RT, UK
    Arch Microbiol 193:407-17. 2011
    ..These strains expressed enzymes associated with methylotrophic metabolism (methanol, methylamine, and formate dehydrogenases), and the assimilation of one-carbon compounds by the serine pathway (..
  26. ncbi Ethylene glycol, methanol and isopropyl alcohol intoxication
    Divakar Jammalamadaka
    Department of Internal Medicine, Saint Mary s Hospital, Waterbury, Connecticut 06706, USA
    Am J Med Sci 339:276-81. 2010
    In clinical practice, poisoning with ethylene glycol, methanol, and isopropyl alcohol is common. These alcohol-related intoxications can present with high anion gap metabolic acidosis and increased osmolality...
  27. ncbi Anti-angiogenic activity of methanol extract of Phellinus linteus and its fractions
    Yeon Sil Lee
    Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, 39 Hallym daehakgil, Chuncheon 200 702, Republic of Korea
    J Ethnopharmacol 131:56-62. 2010
    ..The aim of the present study was to investigate the effects of MeOH extract of PL (PLME) and its fractions on angiogenesis...
  28. ncbi Root nodule bacteria isolated from South African Lotononis bainesii, L. listii and L. solitudinis are species of Methylobacterium that are unable to utilize methanol
    Julie Kaye Ardley
    Centre for Rhizobium Studies, School of Biological Sciences and Biotechnology, Murdoch University, Perth, WA, Australia
    Arch Microbiol 191:311-8. 2009
    ..Methylobacterium spp. are characterized by their ability to utilize methanol and other C(1) compounds, but 11 Lotononis isolates neither grew on methanol as a sole carbon source nor were ..
  29. ncbi Combined effect of the methanol utilization (Mut) phenotype and gene dosage on recombinant protein production in Pichia pastoris fed-batch cultures
    Oriol Cos
    Departament d Enginyeria Quimica, ETSE, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    J Biotechnol 116:321-35. 2005
    ..drastically influence protein production and cultivation process development in this system are gene dosage and methanol assimilation capacity of the host strain (Mut phenotype)...
  30. pmc Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the hepatitis B surface antigen
    Heinrich Lünsdorf
    Helmholtz Centre for Infection Research VAM, Braunschweig, Germany
    Microb Cell Fact 10:48. 2011
    ..So far, no clear evidence has been presented showing whether HBsAg assembles in vivo inside the yeast cell into VLPs or later in vitro during down-stream processing and purification...
  31. pmc Propionate oxidation by and methanol inhibition of anaerobic ammonium-oxidizing bacteria
    Didem Güven
    Department of Microbiology, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Appl Environ Microbiol 71:1066-71. 2005
    ..It was shown that alcohols inhibited anammox bacteria, while organic acids were converted by them. Methanol was the most potent inhibitor, leading to complete and irreversible loss of activity at concentrations as low as ..
  32. pmc The expanding world of methylotrophic metabolism
    Ludmila Chistoserdova
    Departments of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Microbiol 63:477-99. 2009
    ..We also review new directions in methylotroph ecology that improve our understanding of the role of methylotrophy in global biogeochemical processes, along with an outlook for the future challenges in the field...
  33. pmc Methanol extract of Ocimum gratissimum protects murine peritoneal macrophages from nicotine toxicity by decreasing free radical generation, lipid and protein damage and enhances antioxidant protection
    Santanu Kar Mahapatra
    Immunology and Microbiology Laboratory, Department of Human Physiology, Community Health, Vidyasagar University, Midnapore, West Bengal, India
    Oxid Med Cell Longev 2:222-30. 2009
    In the present study, methanol extract of Ocimum gratissimum Linn (ME-Og) was tested against nicotine-induced murine peritoneal macrophage in vitro...
  34. pmc Recombinant protein expression in Pichia pastoris strains with an engineered methanol utilization pathway
    Florian W Krainer
    Graz University of Technology, Institute of Molecular Biotechnology, Graz, Austria
    Microb Cell Fact 11:22. 2012
    ..yeast Pichia pastoris has become an important host organism for recombinant protein production and is able to use methanol as a sole carbon source...
  35. ncbi Old yellow enzyme confers resistance of Hansenula polymorpha towards allyl alcohol
    Janet A Komduur
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute GBB, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Curr Genet 41:401-6. 2002
    In the methylotrophic yeast, Hansenula polymorpha, peroxisomes are formed during growth on methanol as sole carbon and energy source and contain the key enzymes for its metabolism, one of the major enzymes being alcohol oxidase (AO)...
  36. ncbi Methylselenol, a selenium metabolite, induces cell cycle arrest in G1 phase and apoptosis via the extracellular-regulated kinase 1/2 pathway and other cancer signaling genes
    Huawei Zeng
    USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 139:1613-8. 2009
    ..The regulation of these genes is likely to play a key role in G1 cell cycle arrest and apoptosis, which may contribute to the inhibition of tumor cell invasion...
  37. pmc Purification of the formate-tetrahydrofolate ligase from Methylobacterium extorquens AM1 and demonstration of its requirement for methylotrophic growth
    Christopher J Marx
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    J Bacteriol 185:7169-75. 2003
    ..Furthermore, the ftfL mutant strain remained competent for wild-type conversion of [(14)C]methanol to [(14)C]CO(2)...
  38. pmc A systems biology approach uncovers cellular strategies used by Methylobacterium extorquens AM1 during the switch from multi- to single-carbon growth
    Elizabeth Skovran
    Department of Chemical Engineering, University of Washington, Seattle, Washington, USA
    PLoS ONE 5:e14091. 2010
    ..These different modes of growth utilize dramatically different central metabolic pathways with limited pathway overlap...
  39. ncbi Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro
    Chien Min Yang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, No 100, Shin Chuan 1 st Road, Kaohsiung Medical University, 807 Kaohsiung, Taiwan, ROC
    Antiviral Res 67:24-30. 2005
    ..urinaria were investigated in vitro by plaque reduction assay. Results showed that acetone, ethanol and methanol extracts of P. urinaria inhibited HSV-2 but not HSV-1 infection...
  40. ncbi Antimicrobial activities of methanol extract and compounds from stem bark of Vismia rubescens
    Jean de Dieu Tamokou
    Department of Biochemistry, Faculty of Science, University of Dschang, P O Box 67 Dschang, Cameroon
    J Ethnopharmacol 124:571-5. 2009
    ..The plant, Vismia rubescens (Guttiferae) is popularly used in Cameroon and in several parts of Africa as febrifugal and for the treatment of various microbial infections (skin diseases, diarrhoea and venereal diseases)...
  41. ncbi Biodiesel production from heterotrophic microalgal oil
    Xiaoling Miao
    Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China
    Bioresour Technol 97:841-6. 2006
    ..The best process combination was 100% catalyst quantity (based on oil weight) with 56:1 molar ratio of methanol to oil at temperature of 30 degrees C, which reduced product specific gravity from an initial value of 0...
  42. ncbi Heterologous protein production in methylotrophic yeasts
    G Gellissen
    Rhein Biotech GmbH, Dusseldorf, Germany
    Appl Microbiol Biotechnol 54:741-50. 2000
    ..They are based on strong and regulatable promoters for expression control derived from methanol metabolism pathway genes...
  43. ncbi Sorbitol co-feeding reduces metabolic burden caused by the overexpression of a Rhizopus oryzae lipase in Pichia pastoris
    Ramon Ramon
    Departament d Enginyeria Quimica, ETSE, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Biotechnol 130:39-46. 2007
    ..pastoris, the effect of sorbitol/methanol mixed substrates was tested in batch and fed-batch cultures...
  44. ncbi In vitro antibacterial, antifungal, and antioxidant activities of the essential oil and methanol extracts of herbal parts and callus cultures of Satureja hortensis L
    M Gulluce
    Department of Biology, Faculty of Art and Science, Ataturk University, Erzurum 25240, Turkey
    J Agric Food Chem 51:3958-65. 2003
    ..a Clevenger distillation apparatus, water soluble (polar) and water insoluble (nonpolar) subfractions of the methanol extracts from aerial parts of Satureja hortensis L...
  45. ncbi Engineering the Pichia pastoris methanol oxidation pathway for improved NADH regeneration during whole-cell biotransformation
    Kirsten Schroer
    Research Centre Applied Biocatalysis, Petersgasse 14, A 8010 Graz, Austria
    Metab Eng 12:8-17. 2010
    ..Here, we present a new engineering strategy for improved NADH regeneration based on the Pichia pastoris methanol oxidation pathway...
  46. ncbi Strategies for optimal synthesis and secretion of heterologous proteins in the methylotrophic yeast Pichia pastoris
    K Sreekrishna
    Hoechst Marion Roussel, Inc, Cincinnati, OH 45215 6300, USA
    Gene 190:55-62. 1997
    ..have been produced at greater than gram per liter levels in the methylotrophic yeast, Pichia pastoris, using the methanol oxidase promoter...
  47. ncbi Theoretical kinetic study of the formation reactions of methanol and methyl hypohalites in the gas phase
    Katarzyna Brudnik
    Department of Physical Chemistry, Wroclaw Medical University, pl Nankiera 1, 50 140, Wroclaw, Poland
    J Mol Model 15:1061-6. 2009
    ..The kinetic equations derived in this study allow a description of the kinetics of the reactions under investigation in the temperature range of 200-500 K...
  48. ncbi Cofactor-dependent pathways of formaldehyde oxidation in methylotrophic bacteria
    Julia A Vorholt
    Laboratoire de Biologie Moleculaire des relations Plantes Microorganismes, INRA CNRS, BP27, 31326 Castanet Tolosan, France
    Arch Microbiol 178:239-49. 2002
    Methylotrophic bacteria can grow on a number of substrates as energy source with only one carbon atom, such as methanol, methane, methylamine, and dichloromethane. These compounds are metabolized via the cytotoxin formaldehyde...
  49. ncbi Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation
    Télesphore B Nguelefack
    Laboratory of Animal Physiology and Phytopharmacology, Faculty of Sciences, University of Dschang, P O BOX 67, Dschang, Cameroon
    J Ethnopharmacol 128:567-74. 2010
    ..Dioscorea bulbifera var sativa is a medicinal plant commonly used in Cameroonian traditional medicine to treat pain and inflammation...
  50. ncbi The relationship of methanol and formate concentrations in fatalities where methanol is detected
    Graham R Jones
    Office of the Chief Medical Examiner, Edmonton, AB, Canada
    J Forensic Sci 52:1376-82. 2007
    ..for the determination of formate (formic acid) in postmortem specimens, based on the in situ sulfuric acid-methanol methylation of formic acid to methyl formate. Diisopropyl ether was used as an internal standard...
  51. ncbi A new methanol assimilating yeast, Ogataea parapolymorpha, the ascosporic state of Candida parapolymorpha
    Cletus P Kurtzman
    Bacterial Foodborne Pathogens and Mycology Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, 1815 North University Street, Peoria, IL 61604, USA
    Antonie Van Leeuwenhoek 100:455-62. 2011
    ..The species appears homothallic, assimilates methanol as is typical of most Ogataea species and forms hat-shaped ascospores in asci that become deliquescent. O...
  52. ncbi Efficient hydrogenation of organic carbonates, carbamates and formates indicates alternative routes to methanol based on CO2 and CO
    Ekambaram Balaraman
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Nat Chem 3:609-14. 2011
    ..their mild hydrogenation can provide alternative, mild approaches to the indirect hydrogenation of CO2 and CO to methanol, an important fuel and synthetic building block...
  53. ncbi Methanol extract of Sanguisorba officinalis L. with cytotoxic activity against PC3 human prostate cancer cells
    Eun Sun Choi
    Department of Oral Pathology, School of Dentistry, Institute of Oral Bioscience, Chonbuk National University, Jeonju 561 756, Republic of Korea
    Mol Med Rep 6:670-4. 2012
    ..In the present study, we investigated the inhibitory effects and underlying mechanisms of a methanol extract of Sanguisorba officinalis (MESO) in PC3 human prostate cancer cells...
  54. ncbi Anti-inflammatory effects of kudingcha methanol extract (Ilex kudingcha C.J. Tseng) in dextran sulfate sodium-induced ulcerative colitis
    Jia Le Song
    Department of Food Science and Nutrition, Pusan National University, Busan 609 735, Republic of Korea
    Mol Med Rep 8:1256-62. 2013
    The present study aimed to investigate the anti‑inflammatory effects of Ilex kudingcha C.J. Tseng methanol extracts (KME) on 3% dextran sulfate sodium (DSS)‑induced ulcerative colitis (UC) in mice (C57BL/6J strain)...
  55. ncbi Fatal methanol intoxication with different survival times--morphological findings and postmortem methanol distribution
    H Andresen
    Institute of Legal Medicine, University of Hamburg, Germany
    Forensic Sci Int 179:206-10. 2008
    Three corresponding cases of fatal methanol intoxication with different survival times were investigated ante-mortem and postmortem. Ante-mortem serum methanol concentrations were determined during treatment in hospital for 4 days...
  56. pmc An anaerobic, intrachamber incubator for growth of Methanosarcina spp. on methanol-containing solid media
    W W Metcalf
    Department of Microbiology, University of Illinois, Urbana 61801, USA
    Appl Environ Microbiol 64:768-70. 1998
    ..In one operation, it is possible to incubate 153 petri plates, the equivalent of 11 standard anaerobic jars, with plating efficiencies identical to those of traditional protocols...
  57. ncbi Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models
    Elisângela Saturnino de Souza Almeida
    Department of Basic Sciences in Health, Faculty of Medical Sciences, Federal University of Mato Grosso UFMT, Av Fernando Correa da Costa, no 2367, Coxipó, Cuiaba, Mato Grosso Zip Code 78060 900, Brazil
    J Ethnopharmacol 134:630-6. 2011
    ..Simaba ferruginea A. St-Hil. (Simaroubaceae) is a subshrub typical of the Brazilian Cerrado, whose rhizomes are popularly used as infusion or decoction for the treatment of gastric ulcers, diarrhea and fever...
  58. pmc Yap1-regulated glutathione redox system curtails accumulation of formaldehyde and reactive oxygen species in methanol metabolism of Pichia pastoris
    Taisuke Yano
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Eukaryot Cell 8:540-9. 2009
    ..regeneration reaction, has been found to play a critical role in the yeast Pichia pastoris during growth on methanol, and this regulation was at least partly executed by the transcription factor PpYap1...
  59. ncbi Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae)
    J O Moody
    Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    J Ethnopharmacol 104:87-91. 2006
    ..The fruit methanol extract (79.58% inhibition at 200 mg kg(-1)) gave a higher anti-inflammatory activity than the root extract (53...
  60. ncbi Immunostimulatory effect of methanol extract of Curculigo orchioides on immunosuppressed mice
    A R Bafna
    Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Baroda 390001, Gujarat, India
    J Ethnopharmacol 104:1-4. 2006
    The methanol extract of rhizomes of Curculigo orchioides Gaertn. (Amaryllidaceae) holds potential as a protective agent against cytotoxic drugs...
  61. ncbi Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50 degrees C
    Trygve Brautaset
    Department of Biotechnology, SINTEF Materials and Chemistry, 7465, Trondheim, Norway
    Appl Microbiol Biotechnol 87:951-64. 2010
    ..Wild-type MGA3 cells secreted 0.4 g/l L-lysine and 59 g/l L-glutamate under optimised fed batch methanol fermentation...
  62. pmc Genome sequence of thermotolerant Bacillus methanolicus: features and regulation related to methylotrophy and production of L-lysine and L-glutamate from methanol
    Tonje M B Heggeset
    SINTEF Materials and Chemistry, Department of Biotechnology, SINTEF, Trondheim, Norway
    Appl Environ Microbiol 78:5170-81. 2012
    Bacillus methanolicus can utilize methanol as its sole carbon and energy source, and the scientific interest in this thermotolerant bacterium has focused largely on exploring its potential as a biocatalyst for the conversion of methanol ..
  63. ncbi Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB₁ in human lymphocytes in vitro
    Elif Kotan
    Department of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey
    Toxicol Ind Health 27:599-605. 2011
    In this study, the antigenotoxic and antioxidant effects of Cetraria islandica methanol (CME) extract were determined by using sister chromatid exchange (SCE), micronuclei (MN) assays and superoxide dismutase (SOD) and glutathione ..
  64. ncbi Effect of 4-methylpyrazole on endogenous plasma ethanol and methanol levels in humans
    T Sarkola
    Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland
    Alcohol Clin Exp Res 25:513-6. 2001
    Endogenous methanol and ethanol levels are found in human blood...
  65. ncbi Acute methanol intoxication generates free radicals in rats: an ESR spin trapping investigation
    M B Kadiiska
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 28:1106-14. 2000
    Electron spin resonance (ESR) spectroscopy has been used to investigate free radical generation in rats with acute methanol poisoning...
  66. ncbi Specific roles of methylcobamide:coenzyme M methyltransferase isozymes in metabolism of methanol and methylamines in Methanosarcina barkeri
    D J Ferguson
    Department of Microbiology, The Ohio State University, Columbus, 43210, USA
    J Biol Chem 271:5189-94. 1996
    ..M methyltransferase (MT2-M and MT2-A) in the metabolic pathways of methane formation from: methanol, acetate, monomethylamine, dimethylamine, and trimethylamine...
  67. ncbi Evaluation of in vivo wound healing activity of methanol extract of Achyranthes aspera L
    Abraham Fikru
    Faculty of Veterinary Medicine, University of Gondar, P O Box 196, Gondar, Ethiopia
    J Ethnopharmacol 143:469-74. 2012
    ..However, the plant has not been explored scientifically for its wound healing activity. Therefore, this study was designed to investigate the wound healing activity of methanol extract of Achyranthes aspera L. leaves in rats.
  68. ncbi In vitro antioxidant activities of the methanol extract and its different solvent fractions obtained from the fruit pericarp of Terminalia bellerica
    Suresh V Nampoothiri
    Agroprocessing and Natural Products Division, National Institute for Interdisciplinary Science and Technology, CSIR, Thiruvananthapuram, Kerala 695019, India
    Nat Prod Res 25:277-87. 2011
    ..In this study, the free radical scavenging and antioxidant activities of methanol extract (ME) and its different solvent fractions (namely hexane (HE), ethyl acetate (EA), butanol (BL) and water (..
  69. ncbi In vitro and in vivo anti-inflammatory effect of Rhodomyrtus tomentosa methanol extract
    Deok Jeong
    Department of Genetic Engineering, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    J Ethnopharmacol 146:205-13. 2013
    ..is a representative Thai medicinal plant traditionally used in South Asian countries to relieve various inflammatory symptoms. However, no systematic studies on its anti-inflammatory activity and mechanisms have been reported...
  70. pmc Induction without methanol: novel regulated promoters enable high-level expression in Pichia pastoris
    Roland Prielhofer
    University of Natural Resources and Life Sciences, Department of Biotechnology, Muthgasse 18, Vienna 1190, Austria
    Microb Cell Fact 12:5. 2013
    ..g. glycerol, while heterologous gene expression should be active in the feed phase under carbon (e.g. glucose) limitation...
  71. ncbi Distinct regulators control the expression of methanol methyltransferase isozymes in Methanosarcina acetivorans C2A
    Arpita Bose
    Department of Microbiology, University of Illinois at Urbana Champaign, B103 CLSL, 601 S Goodwin, Urbana, IL 61801, USA
    Mol Microbiol 67:649-61. 2008
    The mtaCB1, mtaCB2 and mtaCB3 operons encode isozymes of methanol methyltransferases in Methanosarcina acetivorans C2A and are among the most highly regulated genes known in Archaea...
  72. pmc Glucose-methanol co-utilization in Pichia pastoris studied by metabolomics and instationary ¹³C flux analysis
    Joel Jordà
    Department of Chemical Engineering, Escola d Enginyeria, Universitat Autonoma de Barcelona, Bellaterra, Cerdanyola del Valles, Spain
    BMC Syst Biol 7:17. 2013
    Several studies have shown that the utilization of mixed carbon feeds instead of methanol as sole carbon source is beneficial for protein production with the methylotrophic yeast Pichia pastoris...
  73. ncbi Changes in the LHCII-mediated energy utilization and dissipation adjust the methanol-induced biomass increase
    E Navakoudis
    Department of Biology, University of Crete, P O Box 2208, GR 71409 Heraklion, Crete, Greece
    Biochim Biophys Acta 1767:948-55. 2007
    Considerably low methanol concentrations of 0.5% (v/v), induce an immense increase in biomass production in cultures of the unicellular green alga Scenedesmus obliquus compared to controls without additional methanol...
  74. pmc XoxF is required for expression of methanol dehydrogenase in Methylobacterium extorquens AM1
    Elizabeth Skovran
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195 2180, USA
    J Bacteriol 193:6032-8. 2011
    In Gram-negative methylotrophic bacteria, the first step in methylotrophic growth is the oxidation of methanol to formaldehyde in the periplasm by methanol dehydrogenase...
  75. ncbi Process optimization for biodiesel production from mahua (Madhuca indica) oil using response surface methodology
    Shashikant Vilas Ghadge
    Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur 721 302, India
    Bioresour Technol 97:379-84. 2006
    A central composite rotatable design was used to study the effect of methanol quantity, acid concentration and reaction time on the reduction of free fatty acids content of mahua oil during its pretreatment for making biodiesel...
  76. pmc Hyperglycemia is a strong prognostic factor of lethality in methanol poisoning
    Hossein Sanaei-Zadeh
    Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
    J Med Toxicol 7:189-94. 2011
    b>Methanol poisoning is seen in the form of isolated episodes, or intentional ingestion and epidemics. Despite its efficient treatment, methanol poisoning has high morbidity and mortality rates...
  77. ncbi Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves
    Chi Rei Wu
    Graduate Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsieh Shih Road, Taichung 40402, Taiwan
    Molecules 16:1-15. 2011
    ..The methanol extracts from Ligustrum plants leaves effectively inhibited nociceptive responses induced by 1% acetic acid and 1%..
  78. ncbi Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract
    Woo Seok Yang
    Department of Genetic Engineering, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    J Ethnopharmacol 142:287-93. 2012
    ..However, the antiinflammatory mechanism of A. clypearia has not been fully elucidated. This study examined the anti-inflammatory mechanism of a 95% methanol extract (Ac-ME) of A. clypearia in vitro and in vivo.
  79. ncbi Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo
    Chi Luan Wen
    Taiwan Seed Improvement and propagation Station, Council of Agriculture, Propagation Technology Section, Taichung, Taiwan
    J Ethnopharmacol 137:575-84. 2011
    ..This study aimed to explore the folk use of Antrodia cinnamomea on pharmacological grounds to characterize the scientific basis of anti-inflammatory activity...
  80. pmc An integrated proteomics/transcriptomics approach points to oxygen as the main electron sink for methanol metabolism in Methylotenera mobilis
    David A C Beck
    Department of Chemical Engineering, University of Washington, Box 355014, Seattle, Washington 98195, USA
    J Bacteriol 193:4758-65. 2011
    ..close relatives in the genera Methylophilus, Methylobacillus, and Methylovorus, neither exhibit the activity of methanol dehydrogenase nor possess mxaFI genes encoding this enzyme, yet they are able to grow on methanol...
  81. ncbi Methanol strengthens hydrogen bonds and weakens hydrophobic interactions in proteins--a combined molecular dynamics and NMR study
    Soyoun Hwang
    Center for Biological NMR, Department of Chemistry, Texas A and M University, College Station, Texas 77843, United States
    J Phys Chem B 115:6653-60. 2011
    A combined simulation and experimental study was performed to investigate how methanol affects the structure of a model peptide BBA5. BBA5 forms a stable β-hairpin-α-helix structure in aqueous solutions...
  82. ncbi Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity
    Jason M Hansen
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia, USA
    Birth Defects Res A Clin Mol Teratol 73:72-82. 2005
    b>Methanol (CH3OH) is believed to be teratogenic based on rodent studies. The mouse is more sensitive than the rat, but mechanisms of toxicity and identification of teratogenic metabolites are uncertain.
  83. ncbi DNA microarray analysis of Methanosarcina mazei Gö1 reveals adaptation to different methanogenic substrates
    Raymond Hovey
    Department of Biological Sciences, University of Wisconsin Milwaukee, N Maryland Ave 3209, Milwaukee, WI 53211, USA
    Mol Genet Genomics 273:225-39. 2005
    ..the genomic expression patterns of cells grown on either of two alternative methanogenic substrates, acetate or methanol, as sole carbon and energy source...
  84. pmc Yeast methylotrophy and autophagy in a methanol-oscillating environment on growing Arabidopsis thaliana leaves
    Kosuke Kawaguchi
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    PLoS ONE 6:e25257. 2011
    The yeast Candida boidinii capable of growth on methanol proliferates and survives on the leaves of Arabidopsis thaliana. The local methanol concentration at the phyllosphere of growing A...
  85. ncbi Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells
    Aeyung Kim
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    J Cell Physiol 212:386-400. 2007
    ..Furthermore, activation of p38, PKC-delta, and NF-kappaB is a prerequisite for the down-regulation of integrin expression, followed by detachment-mediated apoptosis...
  86. pmc Differential regulation of the three methanol methyltransferase isozymes in Methanosarcina acetivorans C2A
    Arpita Bose
    Department of Microbiology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    J Bacteriol 188:7274-83. 2006
    Genetic analysis of the three methanol-specific methyltransferase 1 operons (mtaCB1, mtaCB2, and mtaCB3) in Methanosarcina acetivorans led to the suggestion that each of them has a discrete function during growth on methanol, which might ..
  87. pmc Pectin methylesterase NaPME1 contributes to the emission of methanol during insect herbivory and to the elicitation of defence responses in Nicotiana attenuata
    Evelyn Körner
    Max Planck Institute for Chemical Ecology, Department of Molecular Ecology, Hans Knöll Str 8, D 07745 Jena, Germany
    J Exp Bot 60:2631-40. 2009
    Pectin methylesterases (PMEs) catalyse the demethylation of pectin within plant cell walls, releasing methanol (MeOH) in the process...
  88. ncbi Functional investigation of methanol dehydrogenase-like protein XoxF in Methylobacterium extorquens AM1
    Sabrina Schmidt
    Institute of Microbiology, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Microbiology 156:2575-86. 2010
    b>Methanol dehydrogenase-like protein XoxF of Methylobacterium extorquens AM1 exhibits a sequence identity of 50 % to the catalytic subunit MxaF of periplasmic methanol dehydrogenase in the same organism...
  89. ncbi Chlorella methanol extract reduces lipid accumulation in and increases the number of apoptotic 3T3-L1 cells
    Jeong Woo Chon
    Department of Medical Nutrition, Graduate School of East West Medical Science, Kyung Hee University, Yongin si, Korea
    Ann N Y Acad Sci 1171:183-9. 2009
    ..In this study, we found that methanol extract of Chlorella reduces lipid accumulation in 3T3-L1 adipocytes...
  90. ncbi Metabolite profiling and quantification of phenolic compounds in methanol extracts of tomato fruit
    María Gómez-Romero
    Department of Analytical Chemistry, Faculty of Sciences, University of Granada, c Fuentenueva s n, 18071 Granada, Spain
    Phytochemistry 71:1848-64. 2010
    ..developed and validated an analytical method for the comprehensive profiling of semi-polar metabolites in the methanol extract of three cultivars of raw tomatoes (Daniela, Raf and Rambo) grown in Almería, in south-east Spain...
  91. pmc Excessive S-adenosyl-L-methionine-dependent methylation increases levels of methanol, formaldehyde and formic acid in rat brain striatal homogenates: possible role in S-adenosyl-L-methionine-induced Parkinson's disease-like disorders
    Eun Sook Lee
    Department of Neurology, Meharry Medical College, Nashville, TN 37208, United States
    Life Sci 83:821-7. 2008
    ..The hydrolysis of the methyl ester bond of the methylated proteins produces methanol. Since methanol is oxidized into formaldehyde, and formaldehyde into formic acid in the body, we investigated the ..
  92. ncbi Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings
    Jeffrey Brent
    Toxicology Associates, University of Colorado, School of Medicine, Denver, CO, USA
    Clin Toxicol (Phila) 48:401-6. 2010
    The use and clinical efficacy of the alcohol dehydrogenase inhibitor fomepizole is well established for the treatment of ethylene glycol and methanol poisonings in adults.
  93. ncbi Acute oral toxicity and brine shrimp lethality of Elaeis guineensis Jacq., (oil palm leaf) methanol extract
    Abdul Rani Muhamad Syahmi
    Universiti Sains Malaysia, Pulau Pinang, Malaysia
    Molecules 15:8111-21. 2010
    ..Maximum mortalities occurred at 100 mg/mL concentration while the least mortalities happened to be at 0.195 mg/mL concentration. The results of both tests confirm that E. guineensis is nontoxic and hence safe for commercial utilization...
  94. ncbi Methanol alters ecto-nucleotidases and acetylcholinesterase in zebrafish brain
    Eduardo Pacheco Rico
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Faculdade de Biociencias, Pontifícia Universidade Católica do Rio Grande do Sul Avenida Ipiranga, 6681, 90619 900, Porto Alegre, RS, Brazil
    Neurotoxicol Teratol 28:489-96. 2006
    b>Methanol is a neurotoxic compound that is responsible for serious damage on CNS. Besides being found as an environmental contaminant, this alcohol is also employed as a component of cryoprotector solutions for zebrafish embryos...
  95. pmc A dynamic method based on the specific substrate uptake rate to set up a feeding strategy for Pichia pastoris
    Christian Dietzsch
    Vienna University of Technology, Institute of Chemical Engineering, Research Area Biochemical Engineering, Vienna, Austria
    Microb Cell Fact 10:14. 2011
    ....
  96. pmc Loss of the mtr operon in Methanosarcina blocks growth on methanol, but not methanogenesis, and reveals an unknown methanogenic pathway
    Paula V Welander
    Department of Microbiology, University of Illinois, B103 Chemical and Life Science Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 102:10664-9. 2005
    ..However, in the disproportionation of C-1 compounds, such as methanol, to methane and carbon dioxide, it catalyzes the reverse, endergonic transfer from methyl-CoM to H4SPT, which is ..
  97. ncbi Methanol-associated matrix effects in electrospray ionization tandem mass spectrometry
    Thomas M Annesley
    Department of Pathology, University of Michigan Health Sciences Center, Ann Arbor, MI, USA
    Clin Chem 53:1827-34. 2007
    ..Preliminary observations indicated that the methanol used in the mobile phase could be a source of differential ionization or ion suppression.
  98. pmc Fast growth increases the selective advantage of a mutation arising recurrently during evolution under metal limitation
    Hsin Hung Chou
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Genet 5:e1000652. 2009
    ..We identified a transposition mutation arising recurrently in 30 of 32 independent populations that utilized methanol as a carbon source, but not in any of the 8 that utilized only succinate...
  99. ncbi Antioxidant activities of methanol extract of Sambucus ebulus L. flower
    M A Ebrahimzadeh
    Department of Medicinal Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Postal Code 48189, Sari, Iran
    Pak J Biol Sci 12:447-50. 2009
    In this study antioxidant activity of methanol extract of Sambucus ebulus L. flower was investigated employing various in vitro assay systems, i.e...
  100. ncbi Methanol-induced oxidative stress in rat lymphoid organs
    Narayanaperumal J Parthasarathy
    Immunology Laboratory, Department of Physiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamilnadu, India
    J Occup Health 48:20-7. 2006
    b>Methanol is primarily metabolized by oxidation to formaldehyde and then to formate. These processes are accompanied by formation of superoxide anion and hydrogen peroxide...
  101. ncbi Batch stage study of lipid production from crude glycerol derived from yellow grease or animal fats through microalgal fermentation
    Yanna Liang
    Department of Civil and Environmental Engineering, 1230 Lincoln Dr, Southern Illinois University Carbondale, Carbondale, IL 62901, USA
    Bioresour Technol 101:6745-50. 2010
    ..Higher concentrations of glycerol resulted in decreased cell growth due to substrate inhibition and methanol presence. With 35 g/l, the cellular lipid content was the highest - 73.3% among all the doses tested...

Research Grants64

  1. Cardioprotective Antioxidants from Caribbean Fruits
    AINSLEY PARKINSON; Fiscal Year: 2004
    ..In preliminary studies, the capsules of the ackee fruit and Jamaica cherry fruit were extracted with methanol and partitioned sequentially with hexane and ethyl acetate (EtOAc)...
  2. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. ..
  3. Tb-FISH (Fluorescent in Situ Hybridization) Assay for Direct Detection of M. tube
    JYOTSNA S SHAH; Fiscal Year: 2010
    ..Mycobacterium tuberculosis complex (MTB) ribosomal RNA (rRNA) and Mycobacterium species (rRNA) on a SINGLE methanol fixed smear, prepared either from a culture or directly from a specimen...
  4. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2009
    ..Organic solvents such as methanol and acetonitrile cause significant protein unfolding as mobile phase modifiers to control the resolution of ..
  5. Lung carcinogenesis: Chemoprevention by Indole-3-carbinol
    Fekadu Kassie; Fiscal Year: 2013
    ..Proving the hypothesis that indole-3-carbinol (I3C) inhibits lung tumorigenesis in A/J mouse model provides a solid platform for clinical trials of I3C as a chemopreventive agent against lung cancer. ..
  6. Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma Membranes
    Sang Hyun Oh; Fiscal Year: 2013
    ..The IgMs maintain their cell specificity only when bound to intact plasma membranes. Fixation of any kind (methanol, formaldehyde, freezing) destroys the complex membrane antigen...
  7. Indolecarbinol target proteins and anti-cancer signaling in human melanoma cells
    Gary L Firestone; Fiscal Year: 2013
    ..Our proposed studies will establish the preclinical foundation that is needed to eventually develop novel and low cost I3C-based therapeutic strategies for human skin cancers. ..
  8. Accelerating Cancer Research with Single Cell Arrays
    Heinz Ulrich Weier; Fiscal Year: 2009
    ..will study the effects of DNA nicks or loss and protein cross-links in archival samples comprised of acetic acid: methanol fixed lymphocytes, frozen placental tissues as well formalin-fixed paraffin-embedded tissue blocks. 2...
  9. Protein, Enzyme, and Biological Water Dynamics: 2D Vibrational Echo Spectroscopy
    Michael D Fayer; Fiscal Year: 2011
    ..Denaturation studies with guanidine HCl, urea, methanol, and pH as chemical denaturants will probe the dynamical properties of molten globule states...
  10. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..This application is innovative and timely in bridging basic mechanisms, preclinical models, and human studies of epigenetics and diet. ..
  11. Novel Targets of Indoles in Prostate Cancer
    Fazlul H Sarkar; Fiscal Year: 2013
    ..The results of our study will help to design mechanism-based clinical trials for assessing the role of B-DIM in the prevention and/or treatment of PCa. ..
  12. MtdA, a Key Regulator for Assimilation and Oxidation of C1 Metabolism.
    NORMA CECILIA MARTINEZ-GOMEZ; Fiscal Year: 2012
    ..levels of expression relative to each other of the two methylene-H4MPT dehydrogenases (MtdA and MtdB) grown on methanol, compared to wild-type will be performed. We will assess methanol sensitivity, growth defects, and flux to CO2...
  13. ANIMAL MODELS FOR STUDYING THE GENETICS OF HYPERTENSION
    Oliver Smithies; Fiscal Year: 2013
    ....
  14. New Leads Against Cancer and Infectious Diseases from Puerto Rican Reef Species
    Abimael D Rodriguez; Fiscal Year: 2013
    ..Initial extraction with solvents of different polarities (e.g., hexane, methylene chloride, and methanol) will be monitored using cytotoxicity and anti-microbial activity assays...
  15. Transient catalytic oxygen species in iron enzymes
    Denis A Proshlyakov; Fiscal Year: 2013
    ..is a powerful analog of cytochrome P450 in higher organisms, which is capable of oxidizing methane to methanol. Its highly oxidized intermediate Q contains an unprecedented FeIVFeIV core...
  16. Detection of Ethanol and Interferents in Breath: Validation of a Novel Technology
    Timothy E Morey; Fiscal Year: 2011
    ..g., acetone, methanol), which commonly interfere with the function of present sensor technologies, and 3) establish mGC-MOS accuracy in ..
  17. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative
    JOHN J BOWSER; Fiscal Year: 2013
    ..During Phase I CMS will build a dehydration system and demonstrate dehydration of a number of solvents including methanol. The goal is water/methanol selectivity greater than 15.0...
  18. Nonheme diiron enzymes: understanding oxygen activation in human deoxyhypusine hy
    Lisa Engstrom; Fiscal Year: 2013
    ..involved in the synthesis of many biologically and industrially relevant compounds, including the formation of methanol, the biosynthesis of antibiotics, and the creation of DNA building blocks from RNA...
  19. Production of Pilot Scale Libraries of Marine Natural Products
    Amy E Wright; Fiscal Year: 2012
    ..provided will meet the MLSMR's criteria of 10 mg, >90% purity and solubility in either chloroform:methanol 9:1 or DMSO...
  20. Dietary Prevention of Obesity-Enhanced Liver Cancer
    Elizabeth H Jeffery; Fiscal Year: 2012
    ..Most work in this area focuses on sulforaphane and broccoli sprouts, a few laboratories focus on indole-3-carbinol, but very little is known about the impact of the whole vegetable, broccoli, the most common component in our diet. ..
  21. Indole-3-carbinol derivatives with enhanced chemopreventive activities
    Ching Shih Chen; Fiscal Year: 2010
    ..We expect that this project will ultimately yield new drugs that will block or delay the development and/or the progression of prostate cancer. ..
  22. Chemoprevention of inflammation-driven lung cancer
    Fekadu Kassie; Fiscal Year: 2013
    ....
  23. The Role of Aryl Hydrocarbon Receptor in Colon Tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2013
    ..Prior to this work, a thorough characterization of AHR's role in anti- carcinogenesis has never been carefully performed, making these experiments essential, timely and novel. ..
  24. Elucidating the mechanism of particulate methane monooxygenase
    Megen A Culpepper; Fiscal Year: 2013
    ..pMMO efficiently catalyzes the selective oxidation of methane to methanol under ambient conditions...
  25. CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTS
    Marco Colonna; Fiscal Year: 2013
    ..Therefore, we are in a unique position to directly test the impact of specific dietary supplements allegedly associated with anti-cancer activity on tumor surveillance by innate immune cells. ! ..
  26. Molecular Genetics of Primary Congenital Glaucoma
    Mansoor Sarfarazi; Fiscal Year: 2010
    ..This may also provide further insight for development of a more effective therapy for this pediatric ocular condition. ..
  27. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds
    Ning Shangguan; Fiscal Year: 2012
    ..Hydrophilic solvent such as methanol will be used as model solvent to test the hydrophilic NF membranes...
  28. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds
    Ning Shangguan; Fiscal Year: 2011
    ..Hydrophilic solvent such as methanol will be used as model solvent to test the hydrophilic NF membranes...
  29. Mechanisms of Alcohol Hangover Headache
    Dan Levy; Fiscal Year: 2013
    ..Specific Aim 3 will examine whether methanol, one of the major toxic congeners found in alcoholic beverages or its metabolites formate and formic acid ..
  30. Molecular Mechanisms and Application of Ah Receptor-MicroRNA Interactions
    Stephen H Safe; Fiscal Year: 2013
    ..The proposed studies will be the first to characterize the molecular mechanisms of AhR-miR interactions and development of SAhRMs for clinical applications in the treatment of ER-negative breast cancer. ..
  31. The role of the aryl hydrocarbon receptor in colon tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2012
    ..Use models of conditional activation of AHR to determine tissue autonomy of AHR signaling and susceptibility to CRC. Aim 3. Clarify the underlying mechanism of AHR-mediated tumor suppression using recombinant alleles of Arnt and Ahrr. ..
  32. MECHANISMS & INHIBITORS OF PYRIDOXAL-DEPENDENT ENZYMES
    DAVID METZLER; Fiscal Year: 1993
    ..7) We will conduct nonenzymic studies on formation of Al3+ -stabilized quinonoid species in methanol and we will compare rates of alpha hydrogen removal in model systems with pyridoxal phosphate, its N-methyl ..
  33. HPLC and CE of Peptides and Proteins
    Robert S Hodges; Fiscal Year: 2010
    ..shortage of acetonitrile also underlines the necessity of investigating alternative organic modifiers such as methanol, together with RP-HPLC columns with unique selectivities for peptides, for analytical and preparative protocols...
  34. OPTIC NEUROPATHY FROM MITOCHONDRIAL DERANGEMENT
    Alfredo Sadun; Fiscal Year: 1999
    ..developing an analogous animal model of deranged oxidative phosphorylation by administering chronic, low doses of methanol to folic acid deficient rats...
  35. Collection and Taxonomy of Shallow Water Marine Organisms
    Patrick Colin; Fiscal Year: 2009
    ..organism is extracted in the Natural Products Extraction Laboratory with a 1:1 mixture of dichloromethane and methanol, and then with water, and the extracts are stored at -200C in the Natural Products Repository...
  36. Collection and Taxonomy of Shallow Water Marine Organisms
    Patrick Colin; Fiscal Year: 2012
    ..organism is extracted in the Natural Products Extraction Laboratory with a 1:1 mixture of dichloromethane and methanol, and then with water, and the extracts are stored at -200C in the Natural Products Repository...
  37. Collection and Taxonomy of Shallow Water Marine Organisms
    Patrick Colin; Fiscal Year: 2011
    ..organism is extracted in the Natural Products Extraction Laboratory with a 1:1 mixture of dichloromethane and methanol, and then with water, and the extracts are stored at -200C in the Natural Products Repository...
  38. Collection and Taxonomy of Shallow Water Marine Organisms
    Patrick Colin; Fiscal Year: 2010
    ..organism is extracted in the Natural Products Extraction Laboratory with a 1:1 mixture of dichloromethane and methanol, and then with water, and the extracts are stored at -200C in the Natural Products Repository...
  39. Consequences of AhR Activation in Dendritic Cells
    David M Shepherd; Fiscal Year: 2013
    ....
  40. Particulate Methane Monooxygenase
    Amy C Rosenzweig; Fiscal Year: 2013
    ..The first step in their metabolic pathway is the oxidation of methane to methanol by methane monooxygenase (MMO) enzyme systems...
  41. STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL
    CHARLES HERBERT; Fiscal Year: 2011
    ....
  42. STUDIES TO EVALUATE THE TOXICOLOGIC AND CARCINOGENIC POTENTIAL
    CHARLES HERBERT; Fiscal Year: 2009
    ....
  43. BIOLOGICAL METAL CLUSTERS--BIOPHYSICAL & MODEL STUDIES
    Michael Maroney; Fiscal Year: 1991
    ..conversion of ribonucleotides to deoxyribonucleotides ( a key step in DNA synthesis), and oxidation of methane to methanol. In each case, mixed-valent forms of the active site metal cluster appear to be involved in the catalysis or in ..
  44. Studies to evaluate the tox and carcinogentic potential of test articles
    MILTON D HEJTMANCIK; Fiscal Year: 2011
    ..abstract_text> ..
  45. CULTURE, PHYSIOLOGY, GENETICS, INFLUENCING TAXANE YIELDS
    RICK KELSEY; Fiscal Year: 1992
    ..Oven-dried and ground tissues will be methanol extracted and partitioned with methylene chloride and water...
  46. CARBOHYDRATE-CONTAINING MACROMOLECULES IN AGING BRAIN
    ERIC BRUNNGRABER; Fiscal Year: 1980
    ..Human brain tissue from neurological normal human patients are extracted with chloroform-methanol or tetrahydrofuran to recover the gangliosides...
  47. Novel peroxisomal genes in the yeast Pichia pastoris
    James Cregg; Fiscal Year: 2005
    ..are massively and specifically induced in size and number in response to either of two carbon sources, methanol or oleic acid. Primarily through the isolation ofpex mutants in P...
  48. Cancer prevention by indole-3-carbinol via modulation of the epigenome
    Abby D Benninghoff; Fiscal Year: 2010
    ....
  49. GLYCOSIDE ANTAGONISTS OF GLYCOSYLATION
    Jeffrey Esko; Fiscal Year: 2000
    ..Galbeta1-4GlcNAcbeta-O-naphthalenemethanol (AcLacNAc-NM) and acceptilated GlcNAcbeta1-3Galbeta-O-naphthalene-methanol (acGlcNAcGal-NM) permeate cell membranes, prime oligosaccharide synthesis, and alter the expression of important ..
  50. MECHANISMS OF INHIBITION OF CHEMICAL CARCINOGENESIS
    George Bailey; Fiscal Year: 1999
    ..This renewal, along with a separate R-29 (RHD) and R01 (LFB), aim to provide the additional dose-response, risk-benefit, and mechanism studies that we believe necessary if I3C and chlorophylls are to proceed toward clinical trials. ..
  51. PROTECTION FROM ENVIRONMENTAL TOXINS/MUTAGENS BY INDOLES
    HOWARD SHERTZER; Fiscal Year: 1990
    ..These studies will provide the basis for developing dietary and pharmacological strategies to reduce the risk associated with exposure to toxins that act via electrophilic or radical mechanisms...
  52. PROTON TRANSLOCATING SECTOR OF E COLI H+ ATPASE
    ROBERT FILLINGAME; Fiscal Year: 2003
    ..We have shown that subunit c folds in a chloroform-methanol-H2O solvent much like it is predicted to fold in situ...
  53. A Safe Tetramethylbenzidine Buffer for Enzyme Assays
    James Woiszwillo; Fiscal Year: 2002
    ..Several of the solvents used are labeled as toxic substances such as, dimethylformamide, dioxane, and methanol. Some of the suppliers use dimethylsulfoxide but in combination with a hazardous solvent...
  54. BREAST CANCER GENE-DIET INTERACTIONS IN POLISH WOMEN
    Dorothy Pathak; Fiscal Year: 2003
    ..abstract_text> ..
  55. Breast Cancer Gene-Diet Interaction US Polish Migrants
    Dorothy Pathak; Fiscal Year: 2003
    ..abstract_text> ..
  56. A PF-GC for Environmental Health Breath Assessment
    Pavel Smejtek; Fiscal Year: 2004
    ..PFGC has a FID for universal hydrocarbon detection. Major endogenous compounds in human breath are methane, methanol, ethanol, acetone, methyl acetate, and isoprene...
  57. TREHALOSE METABOLISM IN METHYLOTROPHIC YEAST
    EDWARD BELLION; Fiscal Year: 1993
    ..Specifically the amounts of trehalose produced by the yeast when grown on glucose/NH3, methanol/NH3 and glucose/CH3NH2 will be determined and the time courses of trehalose synthesis and hydrolysis when cells ..
  58. BAYLOR BIRCWH PROGRAM
    Joe Simpson; Fiscal Year: 2004
    ..A crude methanol extract will be produced and an HPLC profile established...
  59. METHOD FOR MAKING AN IMPROVED ST JOHN'S WORT PRODUCT
    TREVOR CASTOR; Fiscal Year: 2001
    ..accomplished by following the extraction of bioactive compounds with super critical carbon dioxide with 0 to 20% methanol. The results of Phase I studies will be used to develop a large scale manufacturing process...
  60. Studies to evaluate the tox and carcinogentic potential of test articles
    Milton Hejtmancik; Fiscal Year: 2010
    ..abstract_text> ..
  61. NOVEL GRAMICIDIN DIMER CHANNELS: STRUCTURE AND FUNCTION
    Samuel Cukierman; Fiscal Year: 2003
    ..In particular, the mechanisms by which methanol attenuates proton currents will be explored in detail...
  62. Silanediols as Serine and Threonine Protease Inhibitors
    SCOTT SIEBURTH; Fiscal Year: 2009
    ..The observation that Silanediols undergo facile, uncatalyzed exchange with methanol (initially observed with our HIV protease inhibitor) indicates that they have great potential as serine protease ..
  63. Detection of Ethanol in Human Breath: Mini-GC Use and Exhaled Breath Condensate
    Richard Melker; Fiscal Year: 2007
    ..g., acetone, methanol, toluene) that may interfere with alternative technologies used to detect ethanol in breath...
  64. METHANOL POISONING
    Thomas Tephly; Fiscal Year: 1991
    The objective of this project is to reveal the mechanism of methanol poisoning in humans. To our knowledge only humans and monkeys display characteristic methanol toxicity whereas lower animals, mice and rats, do not...