tramadol

Summary

Summary: A narcotic analgesic proposed for severe pain. It may be habituating.

Top Publications

  1. ncbi Tramadol as an analgesic for mild to moderate cancer pain
    Wojciech Leppert
    Department of Palliative Medicine, Poznan University of Medical Sciences, Osiedle Rusa 25 A, PL 61 245 Poznań, Poland
    Pharmacol Rep 61:978-92. 2009
  2. ncbi Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Med Res Opin 23:147-61. 2007
  3. ncbi Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice
    Padi S V Satyanarayana
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 28:641-9. 2004
  4. ncbi Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice
    Pedro Alvarez
    Programa de Farmacología Molecular y Clínica, Universidad de Chile, Santiago, Chile
    J Orofac Pain 25:354-63. 2011
  5. ncbi The Diversion of Ultram, Ultracet, and generic tramadol HCL
    James A Inciardi
    University of Delaware Research Center, Coral Gables, FL 33134, USA
    J Addict Dis 25:53-8. 2006
  6. ncbi Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats
    J T Cheng
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Diabetes 50:2815-21. 2001
  7. pmc Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia
    Seong Ho Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea
    Korean J Intern Med 24:139-42. 2009
  8. ncbi Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study
    Gary E Ruoff
    Michigan State University College of Medicine, and Westside Family Medical Center, Kalamazoo, Michigan 49009, USA
    Clin Ther 25:1123-41. 2003
  9. ncbi Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial
    Eun Young Lee
    Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Clin Ther 28:2052-60. 2006
  10. ncbi Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users
    James P Zacny
    Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Drug Alcohol Depend 80:273-8. 2005

Detail Information

Publications329 found, 100 shown here

  1. ncbi Tramadol as an analgesic for mild to moderate cancer pain
    Wojciech Leppert
    Department of Palliative Medicine, Poznan University of Medical Sciences, Osiedle Rusa 25 A, PL 61 245 Poznań, Poland
    Pharmacol Rep 61:978-92. 2009
    ..is a debate whether the second step of the WHO analgesic ladder, which, in Poland, is composed of opioids such as tramadol, codeine, dihydrocodeine (DHC), is still needed for cancer pain treatment...
  2. ncbi Randomized study of tramadol/acetaminophen versus placebo in painful diabetic peripheral neuropathy
    Roy Freeman
    Center for Autonomic and Peripheral Nerve Disorders, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Curr Med Res Opin 23:147-61. 2007
    To examine the efficacy and safety of tramadol/acetaminophen (APAP) for the management of painful diabetic peripheral neuropathy (DPN).
  3. ncbi Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice
    Padi S V Satyanarayana
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Prog Neuropsychopharmacol Biol Psychiatry 28:641-9. 2004
    ..study was aimed at evaluating the combination of different NSAIDs, which inhibit cyclooxygenase (COX) enzymes and tramadol against acetic acid-induced writhing in mice...
  4. ncbi Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice
    Pedro Alvarez
    Programa de Farmacología Molecular y Clínica, Universidad de Chile, Santiago, Chile
    J Orofac Pain 25:354-63. 2011
    ..pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory hyperalgesia, and to use this model to investigate the antinociceptive effects of clomipramine and tramadol, two drugs used for the treatment of neuropathic pain.
  5. ncbi The Diversion of Ultram, Ultracet, and generic tramadol HCL
    James A Inciardi
    University of Delaware Research Center, Coral Gables, FL 33134, USA
    J Addict Dis 25:53-8. 2006
    Ultram (tramadol HCL) was approved by the Food and Drug Administration in 1994 as a non-scheduled drug under the Controlled Substance Act...
  6. ncbi Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats
    J T Cheng
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
    Diabetes 50:2815-21. 2001
    The effect of tramadol on the plasma glucose level of streptozotocin (STZ)-induced diabetic rats was investigated...
  7. pmc Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia
    Seong Ho Kim
    Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea
    Korean J Intern Med 24:139-42. 2009
    Acidic saline injections produce mechanical hyperresponsiveness in male Sprague-Dawley rats. We investigated the effect of milnacipran in conjunction with tramadol on the pain threshold in an acidic saline animal model of pain.
  8. ncbi Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study
    Gary E Ruoff
    Michigan State University College of Medicine, and Westside Family Medical Center, Kalamazoo, Michigan 49009, USA
    Clin Ther 25:1123-41. 2003
    b>Tramadol and acetaminophen (APAP) have both shown efficacy in the treatment of lower back pain. The combination of these 2 agents has demonstrated synergistic analgesic action in animal models at specific ratios.
  9. ncbi Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial
    Eun Young Lee
    Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Clin Ther 28:2052-60. 2006
    This study evaluated the efficacy and tolerability of tramadol 37...
  10. ncbi Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users
    James P Zacny
    Department of Anesthesia and Critical Care, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Drug Alcohol Depend 80:273-8. 2005
    b>Tramadol is a mu opioid agonist that also inhibits the reuptake of norepinephrine and serotonin. Because non-medical use of prescription opioids, including tramadol, has increased in the U.S...
  11. ncbi Impact of mailed warning to prescribers on the co-prescription of tramadol and antidepressants
    Deborah Shatin
    Center for Health Care Policy and Evaluation, UnitedHealth Group, Minneapolis, MN 55344, USA
    Pharmacoepidemiol Drug Saf 14:149-54. 2005
    ..in changing prescribing behavior of 'Dear Health Professional (DHP)' letters mailed by the manufacturer to physicians and other health professionals advising them of safety information on co-prescribing of tramadol and antidepressants.
  12. ncbi Antidepressant-like effect of tramadol and its enantiomers in reserpinized mice: comparative study with desipramine, fluvoxamine, venlafaxine and opiates
    M Olga Rojas-Corrales
    Pharmacology and Neuroscience Research Group, Department of Neuroscience, Faculty of Medicine, University of Cadiz, Cadiz, Spain
    J Psychopharmacol 18:404-11. 2004
    b>Tramadol is a centrally acting analgesic that demonstrates opioid and monoaminergic properties. Several studies have suggested that tramadol could play a role in mood improvement...
  13. ncbi Tramadol induces conditioned place preference in rats: interactions with morphine and buprenorphine
    Min Zhang
    National Institute on Drug Dependence, Peking University, Beijing 100191, PR China
    Neurosci Lett 520:87-91. 2012
    Surveys and drug surveillance have demonstrated that the abuse liability of tramadol is considerably low in the general population but appears to be higher in opiate addicts, and this difference could attribute to the poly-drug abuse of ..
  14. ncbi The effects of tramadol and fentanyl on gastrointestinal motility in septic rats
    Ismet Topcu
    Department of Anesthesiology and Intensive Care, Celal Bayar University, Manisa, Turkey
    Anesth Analg 102:876-81. 2006
    In this study, we investigated the effects of tramadol and fentanyl on gastrointestinal transit (GIT) during acute systemic inflammation in an experimental model of cecal ligation and perforation (CLP)...
  15. ncbi Human mu-opioid receptor gene A118G polymorphism predicts the efficacy of tramadol/acetaminophen combination tablets (ultracet) in oxaliplatin-induced painful neuropathy
    Yu Chang Liu
    National Yang Ming University School of Medicine, Taipei, Taiwan, Republic of China
    Cancer 118:1718-25. 2012
    ..The purpose of this study was to assess whether this polymorphism contributes to the variability in response to tramadol/acetaminophen combination tablets (Ultracet) for treating oxaliplatin-induced painful neuropathy.
  16. pmc Chitosan-genipin microspheres for the controlled release of drugs: clarithromycin, tramadol and heparin
    Ruth Harris
    Instituto de Estudios Biofuncionales, Departamento Química Física II, Universidad Complutense Paseo Juan XXIII, Madrid, Spain
    Mar Drugs 8:1750-62. 2010
    ..Clarithromycin, tramadol hydrochloride, and low molecular weight heparin (LMWH) were used as model drugs...
  17. ncbi Effects of tramadol on myocardial ischemia-reperfusion injury
    Ayten Bilir
    Department of Anaesthesiology and Reanimation, Osmangazi University, Medical Faculty, Eskisehir, Turkey
    Scand Cardiovasc J 41:242-7. 2007
    The aim of the present study was to evaluate the effect of tramadol on isolated rat hearts subjected to global ischemia-reperfusion injury.
  18. ncbi Tramadol: a new centrally acting analgesic
    K S Lewis
    Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA
    Am J Health Syst Pharm 54:643-52. 1997
    The pharmacology, pharmacokinetics, efficacy, adverse effects, and dosage and administration of tramadol are reviewed...
  19. ncbi Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy
    Y Harati
    Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX 77030, USA
    J Diabetes Complications 14:65-70. 2000
    The objective of this study was to evaluate the efficacy and safety of tramadol in a 6-month open extension following a 6-week double-blind randomized trial.
  20. ncbi Tramadol improved the efficacy of ketamine-xylazine anaesthesia in young pigs
    Adetola R Ajadi
    Department of Veterinary Medicine and Surgery, University of Agriculture, Abeokuta, Ogun State, Nigeria
    Vet Anaesth Analg 36:562-6. 2009
    To evaluate the influence of premedication with tramadol on xylazine-ketamine anaesthesia in young pigs.
  21. ncbi Postamputation pain and sensory changes in treatment-naive patients: characteristics and responses to treatment with tramadol, amitriptyline, and placebo
    Clive H Wilder-Smith
    Brain Gut Research Group, Bern, Switzerland
    Anesthesiology 103:619-28. 2005
    ..Pain after amputation is common but difficult to treat, and few controlled treatment studies exist...
  22. ncbi Improved liquid chromatographic method for the simultaneous determination of tramadol and its three main metabolites in human plasma, urine and saliva
    Yalda H Ardakani
    Biopharmaceutics and Pharmacokinetic Division, Department of Pharmaceutics, Faculty of Pharmacy, Medical Sciences University of Tehran, 14155 6451 Tehran, Iran
    J Pharm Biomed Anal 44:1168-73. 2007
    b>Tramadol, an analgesic agent, and its main metabolites O-desmethyltramadol (M1), N-desmethyltramadol (M2) and O,N-didesmethyltramadol (M5) were determined simultaneously in human plasma, saliva and urine by a rapid and specific HPLC ..
  23. ncbi Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures
    H Altunkaya
    Department of Anesthesiology, Zonguldak Karaelmas University, School of Medicine, Kozlu Zonguldak, Turkey
    Br J Anaesth 90:320-2. 2003
    Recent studies have shown that a local anaesthetic action of tramadol 5% was able to induce a sensory block to pinprick, touch, and cold similar to that of lidocaine 1%...
  24. ncbi Tramadol, an alternative to morphine for treating posttraumatic pain in the prehospital situation
    M Vergnion
    Emergency Department, CHR de la Citadelle, Liege, Belgium
    Anesth Analg 92:1543-6. 2001
    In this randomized, double-blinded, parallel-group study, we compared the efficacy of tramadol and morphine administered IV for the management of pain in trauma patients in the prehospital situation...
  25. ncbi The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6
    Thomas P Enggaard
    Clinical Pharmacology, University of Southern Denmark
    Anesth Analg 102:146-50. 2006
    b>Tramadol analgesia results from a monoaminergic effect by tramadol itself and an opioid effect of its metabolite (+)-M1 formed by O-demethylation of tramadol by CYP2D6...
  26. ncbi Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models
    Thomas Christoph
    Biomedical Research, Grunenthal GmbH, Aachen, Germany
    Drugs R D 8:51-7. 2007
    ..The effects of tramadol, an atypically acting analgesic with a combined opioid and monoaminergic mechanism of action, and morphine, a ..
  27. ncbi Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy
    Juliana Tabarelli Brondani
    Department of Veterinary Surgery and Anaesthesiology, School of Veterinary Medicine and Animal Science, Sao Paulo State University, Botucatu, Sao Paulo, Brazil
    J Feline Med Surg 11:420-9. 2009
    The analgesic efficacy of tramadol and/or vedaprofen was evaluated in cats submitted for elective ovariohysterectomy, using a randomised double blind placebo controlled design. Forty adult female cats (3.0+/-0.32kg; 1.8+/-0...
  28. ncbi Severe tramadol addiction in a 61 year-old woman without a history of substance abuse
    R Pollice
    Int J Immunopathol Pharmacol 21:475-6. 2008
    We describe here the first case of Tramadol addiction and withdrawal in an elderly female patient in apparently good physical health. We report successful treatment with mirtazapine and clonidine...
  29. ncbi Genetically polymorphic OCT1: another piece in the puzzle of the variable pharmacokinetics and pharmacodynamics of the opioidergic drug tramadol
    M V Tzvetkov
    Department of Clinical Pharmacology, University Medical Center, Georg August University, Gottingen, Germany
    Clin Pharmacol Ther 90:143-50. 2011
    We investigated whether tramadol or its active metabolite, O-desmethyltramadol, are substrates of the organic cation transporter OCT1 and whether polymorphisms in OCT1 affect tramadol and O-desmethyltramadol pharmacokinetics...
  30. ncbi An independent assessment of MEDWatch reporting for abuse/dependence and withdrawal from Ultram (tramadol hydrochloride)
    George E Woody
    Treatment Research Institute, School of Medicine, Philadelphia Va University of Pennsylvania, 600 Public Ledger Building, 150 South Independence Mall W, Philadelphia, PA 19106 3475, USA
    Drug Alcohol Depend 72:163-8. 2003
    Assess the validity of medical products reporting program (MEDWatch) reports of abuse/dependence and withdrawal associated with Ultram (tramadol).
  31. ncbi Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial
    Ronald Emkey
    Radiant Research Reading, Wyomissing, Pennsylvania 19610, USA
    J Rheumatol 31:150-6. 2004
    To evaluate the efficacy and safety of tramadol 37...
  32. ncbi Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population
    Norman R Rosenthal
    Ortho McNeil Pharmaceutical, Raritan, New Jersey 08869, USA
    J Am Geriatr Soc 52:374-80. 2004
    To evaluate the efficacy and safety of adding tramadol 37.5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients.
  33. ncbi The effects of intrathecal tramadol on spinal somatosensory-evoked potentials and motor-evoked responses in rats
    I Ming Jou
    Departments of Orthopedics, National Cheng Kung University Medical Center, Tainan, Taiwan
    Anesth Analg 96:783-8, table of contents. 2003
    b>Tramadol has been proven to exert a local anesthetic-type effect on peripheral nerves in both clinical and laboratory studies...
  34. ncbi Spinal 5-HT7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, O-Desmethyltramadol, via activation of descending serotonergic pathways
    Omer Yanarates
    Department of Anesthesiology and Reanimation, Gulhane Military Academy of Medicine, Ankara, Turkey
    Anesthesiology 112:696-710. 2010
    b>Tramadol is an analgesic drug, and its mechanism of action is believed to be mediated by the mu-opioid receptor. A further action of tramadol has been identified as blocking the reuptake of serotonin (5-HT)...
  35. ncbi Analgesic efficacy and safety of tramadol/ acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial
    Paul M Peloso
    Division of Rheumatology, Roy and Lucille Carver College of Medicine, University of Iowa Health Care E330 GH, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Rheumatol 31:2454-63. 2004
    To evaluate the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325 mg (tramadol/APAP) combination tablets for treatment of chronic low back pain (LBP).
  36. ncbi Tramadol for neuropathic pain
    J Hollingshead
    Royal Sussex County Hospital, Eastern Road, Brighton, UK BN2 5BE
    Cochrane Database Syst Rev 3:CD003726. 2006
    ..Neuropathic pain is a common symptom in many diseases of the peripheral nervous system...
  37. ncbi Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial*
    C Li
    Beijing University First Hospital, Beijing, China
    Curr Med Res Opin 24:3523-30. 2008
    To assess the efficacy and tolerability of flupirtine in comparison with tramadol for the treatment of moderate to severe subacute low back pain (LBP).
  38. ncbi Intravenous magnesium sulphate decreases postoperative tramadol requirement after radical prostatectomy
    P Tauzin-Fin
    DAR III Hôpital Pellegrin Tondu Bordeaux, Bordeaux Cedex, France
    Eur J Anaesthesiol 23:1055-9. 2006
    ..of intravenous magnesium sulphate (Mg) at the induction of anaesthesia to a balanced anaesthetic protocol including wound infiltration, paracetamol and tramadol resulted in improved analgesic efficiency after radical prostatectomy.
  39. ncbi Tramadol/acetaminophen for the treatment of acute migraine pain: findings of a randomized, placebo-controlled trial
    Stephen D Silberstein
    Jefferson Medical College, Philadelphia, PA, USA
    Headache 45:1317-27. 2005
    To compare tramadol/acetaminophen (APAP) and placebo for the management of acute migraine pain.
  40. ncbi Analysis of the antinociceptive effect of systemic administration of tramadol and dexmedetomidine combination on rat models of acute and neuropathic pain
    Ensari Guneli
    Dokuz Eylul University, Institute of Health Sciences, Department of Laboratory Animal Sciences, Izmir, Turkey
    Pharmacol Biochem Behav 88:9-17. 2007
    The aim of the present study was to investigate the possible antinociceptive effect of systemic administration of tramadol and dexmedetomidine either alone or in combination on acute and neuropathic pain models in rats...
  41. ncbi Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain
    Jayne E Edwards
    Pain Research and Nuffield Department of Anesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford, United Kingdom
    J Pain Symptom Manage 23:121-30. 2002
    The primary aims of this study were to assess the analgesic efficacy and adverse effects of single-dose oral tramadol plus acetaminophen in acute postoperative pain and to use meta-analysis to demonstrate the efficacy of the combination ..
  42. ncbi Effects of tramadol on synovial fluid concentrations of substance P and interleukin-6 in patients with knee osteoarthritis: comparison with paracetamol
    M Bianchi
    Department of Pharmacology, University of Milan, Via Vanvitelli, 32, 20129 Milan, Italy
    Int Immunopharmacol 3:1901-8. 2003
    Both the analgesic drugs tramadol and paracetamol are widely used for the symptomatic therapy of osteoarthritis (OA)...
  43. ncbi Effects of the CYP2D6 gene duplication on the pharmacokinetics and pharmacodynamics of tramadol
    Julia Kirchheiner
    Institute of Clinical Pharmacology, Charite University Medicine, Berlin, Germany
    J Clin Psychopharmacol 28:78-83. 2008
    The analgesic drug tramadol is bioactivated by CYP2D6 to the opioid receptor agonist O-desmethyltramadol. Case reports indicated that carriers of the CYP2D6 gene duplication may be at high risk for opioid adverse events...
  44. ncbi Tramadol in neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled trial
    Cecilia Norrbrink
    Spinalis SCI Unit, Karolinska University Hospital, Stockholm, Sweden
    Clin J Pain 25:177-84. 2009
    To assess the efficacy and safety of tramadol for relieving neuropathic pain after spinal cord injury (SCI).
  45. ncbi Genetic factors in pain and its treatment
    Ulrike M Stamer
    Department of Anesthesiology and Intensive Care Medicine, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Curr Opin Anaesthesiol 20:478-84. 2007
    ....
  46. ncbi Tramadol added to lidocaine for intravenous regional anesthesia
    I Acalovschi
    Department of Anesthesia and Intensive Care, Clinical Hospital, University of Medicine and Pharmacy, Cluj-Napoca, Romania
    Anesth Analg 92:209-14. 2001
    ..Sixty volunteers, divided into four groups of 15 each, received IV regional anesthesia of the upper limb with 40 mL tramadol 0.25%, sodium chloride 0.9%, lidocaine 0.5%, or 100 mg tramadol-containing lidocaine 0.5%...
  47. ncbi The pupillary effects of intravenous morphine, codeine, and tramadol in volunteers
    Roger D Knaggs
    University Department of Anaesthesia, Queen s Medical Centre, University Hospital, Nottingham, UK
    Anesth Analg 99:108-12. 2004
    ..We studied the pupillary effects of IV morphine (0.125 mg/kg), codeine (1 mg/kg), tramadol (1.25 mg/kg), or placebo (10 mL 0.9% w/v sodium chloride) in 10 healthy volunteers...
  48. ncbi Nefopam and tramadol for the prevention of shivering during neuraxial anesthesia
    Federico Bilotta
    Department of Anesthesia and Intensive Care, University of Rome La Sapienza, Rome, Italy
    Reg Anesth Pain Med 27:380-4. 2002
    ..We evaluated the usefulness of intravenous (IV) nefopam and tramadol in preventing and reducing the severity of shivering in patients undergoing neuraxial anesthesia for orthopedic ..
  49. pmc Intramuscular tramadol vs. diclofenac sodium for the treatment of acute migraine attacks in emergency department: a prospective, randomised, double-blind study
    Zulfi Engindeniz
    Department of Emergency Medicine, Uludag University Medical Faculty, Acil Tip ABD Gorukle, Bursa 16059, Turkey
    J Headache Pain 6:143-8. 2005
    The aim of this prospective, randomised, double-blind study was to evaluate the efficacy of intramuscular (IM) tramadol 100 mg in emergency department treatment of acute migraine attack and to compare it with that of IM diclofenac sodium ..
  50. ncbi A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain
    Edgar H Adams
    Edgar Adams Consulting, Covance, Princeton, New Jersey 08540, USA
    J Pain Symptom Manage 31:465-76. 2006
    ..The objective of this study was to assess the prevalence of tramadol abuse compared to nonsteroidal anti-inflammatory drugs (NSAIDs) and hydrocodone-containing analgesics in patients ..
  51. ncbi Combination tramadol plus acetaminophen for postsurgical pain
    Adam B Smith
    Department of Surgery, University of North Texas Health Science Center, 855 Montgomery St, Fort Worth, TX 76107, USA
    Am J Surg 187:521-7. 2004
    This multicenter, randomized, double-blind, active- and placebo-controlled trial evaluated tramadol plus acetaminophen (APAP) for orthopedic (n = 153) and abdominal (n = 152) postsurgical pain.
  52. ncbi Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial
    W S Mullican
    Indiana University School of Medicine, Evansville Center for Medical Education, USA
    Clin Ther 23:1429-45. 2001
    ..b>Tramadol is a synthetic analgesic that has been shown to be effective both alone and in combination with APAP...
  53. ncbi Comparison of the efficacy and safety of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy
    S H Ko
    The Catholic University of Korea, Seoul, Korea
    Diabet Med 27:1033-40. 2010
    This study compared the efficacy and safety of tramadol/acetaminophen (T/A) and gabapentin in the management of painful diabetic neuropathy.
  54. ncbi Efficacy of tramadol in treatment of chronic low back pain
    T J Schnitzer
    Office of Clinical Research and Training, Northwestern University, Chicago, IL 60611, USA
    J Rheumatol 27:772-8. 2000
    To evaluate the efficacy and safety of tramadol in the treatment of chronic low back pain.
  55. ncbi Supra-additive effects of tramadol and acetaminophen in a human pain model
    Jörg Filitz
    Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Pain 136:262-70. 2008
    ..Aim of this study was to examine the analgesic and antihyperalgesic properties of the weak opioid tramadol and the non-opioid acetaminophen, alone as well as in combination, in an experimental pain model in humans...
  56. ncbi Efficacy and tolerability of paracetamol/tramadol (325 mg/37.5 mg) combination treatment compared with tramadol (50 mg) monotherapy in patients with subacute low back pain: a multicenter, randomized, double-blind, parallel-group, 10-day treatment study
    Serge Perrot
    Service de Medicine Interne et Consultation de la Douleur, Hôpital Dieu, Paris, France
    Clin Ther 28:1592-606. 2006
    In various pain studies, the single-dose combination of paracetamol/tramadol (PIT) was found to be more effective than either agent alone. PIT could provide benefit in patients with subacute low back pain (LBP).
  57. ncbi The addition of tramadol to lidocaine does not reduce tourniquet and postoperative pain during iv regional anesthesia
    Grégoire Langlois
    Department of Anesthesia, Intensive Care and Pain Clinic, University of Rennes 1, University Hospital of Rennes, France
    Can J Anaesth 49:165-8. 2002
    We conducted a prospective, randomized, double-blind study to determine whether the combination of tramadol with lidocaine 0.5% had an analgesic effect on tourniquet pain during iv regional anesthesia and also on postoperative pain.
  58. ncbi Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes
    U M Stamer
    Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Bonn, Germany
    Clin Pharmacol Ther 82:41-7. 2007
    The influence of CYP2D6 genotype and CYP2D6 inhibitors on enantiomeric plasma levels of tramadol and O-desmethyltramadol as well as response to tramadol was investigated...
  59. ncbi Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study
    Joel C Silverfield
    Tampa Medical Group, PA, Florida 33614, USA
    Clin Ther 24:282-97. 2002
    ....
  60. ncbi The effects of tramadol and morphine on immune responses and pain after surgery in cancer patients
    P Sacerdote
    Department of Pharmacology, University of Milano, Milan, Italy
    Anesth Analg 90:1411-4. 2000
    ..We studied the effects of morphine and tramadol on pain and immune function during the postoperative period in 30 patients undergoing abdominal surgery for ..
  61. pmc Actions of tramadol on micturition in awake, freely moving rats
    Raj Kumar Pandita
    Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden Grünenthal GmbH, Aachen, Germany
    Br J Pharmacol 139:741-8. 2003
    1 (+/-)-Tramadol, a widely used analgesic, is a racemate stimulating opioid receptors and inhibiting reuptake of noradrenaline and serotonin, that is, pharmacological principles previously shown to influence rat micturition...
  62. ncbi Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery
    Antoine Brouquet
    Department of Surgery, AP HP, Hopital Ambroise Pare, Boulogne, France
    Ann Surg 251:759-65. 2010
    ..The aim of this prospective study was to determine incidence, duration, and risk factors for postoperative delirium (PD) in elderly patients undergoing major abdominal surgery...
  63. ncbi Tramadol added to 1.5% mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently
    Sébastien Robaux
    Department of Anesthesiology and Critical Care Medicine, Hopital Central, Nancy Cedex, Nimes Cedex 9, France
    Anesth Analg 98:1172-7, table of contents. 2004
    ..The analgesic, tramadol, has a unique mechanism of action that suggests efficacy as such an adjunct...
  64. ncbi Concordance between tramadol and dextromethorphan parent/metabolite ratios: the influence of CYP2D6 and non-CYP2D6 pathways on biotransformation
    S M Abdel-Rahman
    Department of Pediatrics, University of Missouri Kansas City, USA
    J Clin Pharmacol 42:24-9. 2002
    ..P4502D6 (CYP2D6) activity has been shown to be a determinant of both the pharmacokinetics and pharmacodynamics of tramadol in adults...
  65. ncbi Effects of tramadol and buprenorphine on select immunologic factors in a cecal ligation and puncture model
    Kelly M S Hugunin
    University of Michigan, Ann Arbor, MI, USA
    Shock 34:250-60. 2010
    ..Female ICR mice were divided into four treatment groups (Ringer's lactate solution, high- or low-dose tramadol,buprenorphine) for 3-week mortality studies (n = 12 per treatment)...
  66. ncbi Tramadol reduces myocardial infarct size and expression and activation of nuclear factor kappa B in acute myocardial infarction in rats
    Lin zhong Zhang
    Department of Anesthesiology, Shanxi Medical University, Taiyuan, China
    Eur J Anaesthesiol 26:1048-55. 2009
    ..The aim of this study was to investigate the cardioprotective effect of tramadol and the association of the effect with the changes in expression and activation of nuclear factor kappa B (NF-..
  67. ncbi [Adiuvants in the axillary brachial plexus blockade. Comparison between clonidine, sufentanil and tramadol]
    S Antonucci
    Servizio di Anestesia e Rianimazione, ASL Pescara, , Popoli (Pescara, Italy
    Minerva Anestesiol 67:23-7. 2001
    BACKGROUND: Evaluated effects of tramadol used as adiuvant in brachial plexus block and compared with clonidine and sufentanil...
  68. ncbi Effect of 12-monoketocholic acid on modulation of analgesic action of morphine and tramadol
    Ivan Kuhajda
    Thoracic Surgery Clinic, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Republic of Serbia
    Eur J Drug Metab Pharmacokinet 34:73-8. 2009
    ..with the potential promotive action of 12-monoketocholic acid (12-MKC) on the analgesic effect of morphine and tramadol. The investigation was carried out on laboratory Wistar rats divided into five test groups, each treated with ..
  69. ncbi A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Mecicine, Center of Drug Research and Medical Biotechnology, Hannover, Germany
    Metabolism 52:1439-43. 2003
    ..minutes of blood withdrawal and links carriers of the variant CYP2D6*3 and *4 alleles to the pharmacokinetics of tramadol. This new genotyping assay employs fluorescence resonance energy transfer (FRET) analysis, which permits parallel ..
  70. ncbi Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer
    Ahmed Elkalioubie
    Service de Reanimation Polyvalente, Hopital Roger Salengro, CHRU Lille, Rue Emile Laine, 59037, Lille Cedex, France
    Eur J Clin Pharmacol 67:855-8. 2011
    b>Tramadol is a synthetic, centrally acting analgesic for the treatment of moderate to severe pain...
  71. ncbi Analgesic effects of tramadol, carprofen or multimodal analgesia in rats undergoing ventral laparotomy
    Coralie Zegre Cannon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Lab Anim (NY) 40:85-93. 2011
    In this study, the authors evaluated the analgesic efficacy of tramadol (an opioid-like analgesic), carprofen (a nonsteroidal anti-inflammatory drug) and a combination of both drugs (multimodal therapy) in a rat laparotomy model...
  72. ncbi Tramadol use for axillary brachial plexus blockade
    Serkan Sarsu
    Department of Anesthesiology and Reanimation, Gaziantep University School of Medicine Gaziantep, Gaziantep, Turkey
    J Surg Res 165:e23-7. 2011
    We investigated the effects of tramadol added to the mixture of local anesthetic for axillary brachial plexus blockade (ABB) in patients to have undergone hand and forearm surgery.
  73. ncbi Tramadol vs morphine during adenotonsillectomy for obstructive sleep apnea in children
    Bruce J Hullett
    Department of Anaesthesia and Pain Management, Princess Margaret Hospital for Children, Perth, WA, Australia
    Paediatr Anaesth 16:648-53. 2006
    Optimal analgesia for children undergoing adenotonsillectomy for obstructive sleep apnea (OSA) is controversial. Tramadol may represent a superior choice over morphine in this group, with a potential to cause less postoperative sedation ..
  74. ncbi A comparison of the analgesic efficacy of Tramadol Contramid OAD versus placebo in patients with pain due to osteoarthritis
    Francis Burch
    Radiant Research, San Antonio, Texas, USA
    J Pain Symptom Manage 34:328-38. 2007
    ..multicenter, randomized, double-blind, parallel study designed to assess the analgesic efficacy and safety of Tramadol Contramid OAD compared to placebo...
  75. ncbi A comparison of analgesic efficacy of tramadol and pethidine for management of postoperative pain in children: a randomized, controlled study
    Serdar Ekemen
    Department of Anesthesiology, Osmangazi University Medical School, Eskisehir, Turkey
    Pediatr Surg Int 24:695-8. 2008
    ..Opioids have been used as an analgesic for postoperative pain in children for many years. Tramadol has both opioid and monoaminergic agonist actions...
  76. ncbi Prolonged apnea after small single dose of intravenous tramadol
    Ravindra Pandey
    Department of Anaesthesiology and Intensive Care, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    AANA J 78:110-2. 2010
    We report an unusual case of respiratory depression and prolonged apnea after a single, 50-mg intravenous dose of tramadol. Shortly after an uneventful surgery and anesthesia, the patient was administered intravenous tramadol...
  77. ncbi CYP2D6 polymorphism in relation to tramadol metabolism: a study of faroese patients
    Jónrit Halling
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense C, Denmark
    Ther Drug Monit 30:271-5. 2008
    Several studies have demonstrated the impact of CYP2D6 polymorphism on the pharmacokinetics of tramadol. However, the relationship between the O-demethylation of tramadol and O-desmethyltramadol (M1) and CYP2D6 activity has not previously ..
  78. ncbi Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice
    Ipek Yalcin
    INSERM U 930 FRE CNRS 2448, Faculte des Sciences et Techniques, Universite Francois Rabelais, Parc Grandmont, 37200 Tours, France
    Psychopharmacology (Berl) 200:497-507. 2008
    b>Tramadol is a centrally acting clinically effective analgesic, with a weak opioid receptor affinity...
  79. ncbi Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis
    A Wrzosek
    Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Cracow, Poland
    J Physiol Pharmacol 60:71-8. 2009
    Neuropathic pain constitutes a serious therapeutic problem. In most cases polytherapy is necessary. Tramadol and antidepressants have common mechanisms of action and are frequently used together in clinical practice, thus interaction ..
  80. pmc Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain
    Yong Min Liu
    Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
    J Zhejiang Univ Sci B 9:895-902. 2008
    To evaluate the effects of tramadol on the proinflammatory responses in a rat model of incisional pain by investigating its effects on nociceptive thresholds and serum interleukin-6 (IL-6) and IL-2 levels.
  81. ncbi [Clinical anesthetic effects of epidural ropivacaine with tramadol]
    Jin Cai
    Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:218-20. 2004
    To observe the anesthesic effects of epidural ropivacaine with tramadol during lower limbs surgery.
  82. ncbi Long-term exposure of rats to tramadol alters brain dopamine and alpha 1-adrenoceptor function that may be related to antidepressant potency
    Agata Faron-Górecka
    Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31 343 Krakow, Poland
    Eur J Pharmacol 501:103-10. 2004
    The aim of the present study was to determine whether tramadol, which has a potential antidepressant efficacy, evokes, when administered repeatedly, changes similar to the alterations induced by conventional antidepressant drugs...
  83. ncbi Tramadol does not impair the phagocytic capacity of human peripheral blood cells
    Benzion Beilin
    Department of Anesthesia, Rabin Medical Centre, Golda Campus Hasharon, 7 Keren Kayemet St, Petah Tiqva 47372, Israel
    Can J Anaesth 52:1035-9. 2005
    ..It was the aim of the study to compare the in vitro effect of tramadol with that of morphine on the engulfing ability of peripheral blood phagocytic cells from healthy volunteers.
  84. ncbi [Chronopharmacology of tramadol in mice]
    X P Liu
    Department of Pharmacology, Wannan Medical College, Wuhu 241001, China
    Yao Xue Xue Bao 36:561-4. 2001
    To investigate the influence of dosing time on acute toxicity, action and pharmacokinetics of tramadol in mice to find the circadian rhythms of the drug.
  85. ncbi Abuse, dependence, or withdrawal associated with tramadol
    Allen Brinker
    Am J Psychiatry 159:881; author reply 881-2. 2002
  86. ncbi Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites
    W N Wu
    Division of Preclinical Development, The R W Johnson Pharmaceutical Research Institute, Spring House, PA 19477, USA
    Xenobiotica 32:411-25. 2002
    1. Metabolism of the analgesic agent tramadol hydrochloride has been investigated after a single oral administration of tramadol to three male volunteers (100 mg/subject), and a urine pool (4-12h) was obtained. 2...
  87. ncbi [Effect of droperidol and tramadol combination on the hemostasis in rabbits]
    V V Bol'shakov
    Pharmacology Department, Kemerovo State Medical Academy, ul Voroshilova 22A, Kemerovo, 650029 Russia
    Eksp Klin Farmakol 65:50-2. 2002
    The effect of a combined administration of analgesic droperidol and neuroleptic tramadol (tramal) on the plasma coagulation and platelet aggregation was studied on awake rabbits...
  88. ncbi Advances in perioperative pain management: use of medications with dual analgesic mechanisms, tramadol & tapentadol
    Vaughn E Nossaman
    Department of Pharmacology, Tulane University Medical Center, 1430 Tulane Avenue, New Orleans, LA 70129, USA
    Anesthesiol Clin 28:647-66. 2010
    ..b>Tramadol and tapentadol hydrochloride are novel in that their analgesic actions occur at multiple sites...
  89. ncbi Comparison the analgesic effects of single dose administration of tramadol or piroxicam on postoperative pain after cesarean delivery
    Amir Farshchi
    Department of Pharmacology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
    Acta Med Iran 48:148-53. 2010
    ..pain in a double-blinded, randomized, single-dose comparison of the monoaminergic and mu-opioid agonist tramadol, 100 mg (Group T) and piroxicam 20 mg (Group P) given IM alone--single dose in 150 patients who had elective ..
  90. ncbi Evaluation of dosages and routes of administration of tramadol analgesia in rats using hot-plate and tail-flick tests
    Coralie Zegre Cannon
    Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Lab Anim (NY) 39:342-51. 2010
    b>Tramadol is an opioid-like analgesic with relatively mild side effects...
  91. ncbi Pharmacokinetics of tramadol and its three main metabolites in healthy male and female volunteers
    Yalda H Ardakani
    Biopharmaceutics and Pharmacokinetic Division, Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, 14155 6451, Tehran, Iran
    Biopharm Drug Dispos 28:527-34. 2007
    By using a high-performance liquid chromatography method, the pharmacokinetics of the tramadol (T) and its three main metabolites, O-desmethyltramadol (M1), N-desmethyltramadol (M2) and O,N-didesmethyltramadol (M5) was studied in healthy ..
  92. ncbi Drug dependence and abuse potential of tramadol
    Z M Liu
    National Institute on Drug Dependence, Beijing, China
    Zhongguo Yao Li Xue Bao 20:52-4. 1999
    To assess the drug dependence and abuse liability of tramadol.
  93. pmc Tramadol and propentofylline coadministration exerted synergistic effects on rat spinal nerve ligation-induced neuropathic pain
    Jin Zhang
    Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, China
    PLoS ONE 8:e72943. 2013
    Neuropathic pain is an intractable clinical problem. Drug treatments such as tramadol have been reported to effectively decrease neuropathic pain by inhibiting the activity of nociceptive neurons...
  94. ncbi Synergism between fentanyl and tramadol in tonic inflammatory pain: the orofacial formalin test
    Hugo F Miranda
    Pharmacology Program, School of Medicine, ICBM, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    Inflammation 35:1132-7. 2012
    ..present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent ..
  95. ncbi Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine
    M Mohta
    Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dehli, India
    Anaesthesia 64:141-6. 2009
    The present study was conducted with the aims of comparing intravenous tramadol 1, 2 and 3 mg.kg(-1) with pethidine 0.5 mg...
  96. ncbi Tramadol/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe pain
    Sohita Dhillon
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Clin Drug Investig 30:711-38. 2010
    b>Tramadol/paracetamol 37...
  97. pmc Attenuation of C-reactive protein increases after exodontia by tramadol and ibuprofen
    Eman A El-Sharrawy
    Department of Oral and Maxillofacial Surgery, Tanta University, Cairo, Egypt
    Anesth Prog 53:78-82. 2006
    The anti-inflammatory effects of ibuprofen and tramadol were investigated by measuring C-reactive protein concentrations after removal of an impacted lower third molar...
  98. ncbi Population pharmacokinetic modelling of tramadol with application of the NPEM algorithms
    S H Gan
    Department of Pharmacology, School of Medical Science, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
    J Clin Pharm Ther 29:455-63. 2004
    Although the kinetic behaviour of tramadol has been described, the present study is the first to our knowledge, to report specifically on the population pharmacokinetic modelling of tramadol hydrochloride.
  99. ncbi The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats
    Leda Gaspani
    Department of Pharmacology, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy
    J Neuroimmunol 129:18-24. 2002
    ..We have previously shown that the analgesic drug tramadol stimulates NK activity both in the rodent and in the human...
  100. ncbi Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy?
    Yavuz Demiraran
    Department of Anesthesiology, School of Medicine, Abant Izzet Baysal University, Konuralp Duzce, Turkey
    Paediatr Anaesth 16:1047-50. 2006
    It has been demonstrated that tramadol is an effective analgesic. We aimed to compare postoperative analgesic effects of wound infiltration with tramadol (T) or bupivacaine (B) and intramuscular tramadol (I) after herniotomy in children.
  101. pmc Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk
    Kenneth F Ilett
    Pharmacology and Anaesthesiology Unit, School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia
    Br J Clin Pharmacol 65:661-6. 2008
    There are presently no published data on tramadol transfer into breast milk or on its effects in the breastfed infant.

Research Grants41

  1. Licit &Illicit Opioids: Comparative Studies in Humans
    Sharon L Walsh; Fiscal Year: 2013
    ..to have low abuse liability but, based upon surveillance studies, are emerging as new drugs of abuse, including tramadol, buprenorphine (Subutex(R)) and buprenorphine/naloxone (Suboxone(R))...
  2. Increasing efficacy of antineoplastic drugs with gap junction enhancers
    Thu Annelise Nguyen; Fiscal Year: 2010
    ..Recently, He et al. (2009) showed that tramadol and flurbiprofen depress the cytotoxicity of cisplatin through their effects of gap junction inhibition...
  3. Combined Behavioral &Analgesic Trial for Fibromyalgia (COMBAT-FM)
    DENNIS CHARLES TURK; Fiscal Year: 2013
    ..combination of a modified version of CBT, CBTfm that targets fatigue, sleep, pain, depression, and anxiety and tramadol, a medication that has analgesic, antiserotonergic properties, and inhibits the neuronal reuptake of ..
  4. Overcoming Tramadol Resistance In CYP2D6 Poor Metabolizers
    John A Zebala; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Tramadol is a widely prescribed analgesic, with over 25 million prescriptions and $565 million in retail sales in 2009, making it among the best selling generic drugs...
  5. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2003
    ..focusing on four oral drugs commonly used in outpatient settings: hydrocodone, oxycodone, propoxyphene, and tramadol. In the second series of studies, we will follow up on a study from the previous granting period in which some of ..
  6. Medications Development for Drug Abuse Disorders
    Eric C Strain; Fiscal Year: 2013
    ..by applicant): This grant has funded human laboratory studies examining the pharmacological characteristics of tramadol, an atypical opioid analgesic...
  7. Multi-day Pain Management Therapy with Novel Injectable Formulation
    Milind Singh; Fiscal Year: 2011
    ..Using tramadol, an unscheduled opioid, this project aims to create a long-acting (up to 5-day) tramadol formulation in an ..
  8. Overcoming Tramadol Resistance In CYP2D6 Poor Metabolizers
    John A Zebala; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tramadol is a widely prescribed analgesic, with 18,526,000 prescriptions and $281,559,000 in retail sales in 2007, making it the 31st best selling generic drug...
  9. Molecular Genetics of Inattention in Australia
    THEODORE CICERO; Fiscal Year: 2009
    ..This will be at a marked cost savings due to the employment of existing well-characterized samples and the long history of collaborative studies between investigators from Australia and the United States. ..
  10. Neuropharmacology of Tramadol: Clinical Efficacy and Abuse Potential
    WILLIAM WALTON STOOPS; Fiscal Year: 2010
    ..b>Tramadol is an unscheduled atypical analgesic with opioid activity...
  11. OPIATE ENDOCRINE INTERACTIONS--DEVELOPMENTAL ASPECTS
    THEODORE CICERO; Fiscal Year: 2003
    ..The proposed animal studies could establish whether gender differences exist and if these differences are based on inherent, first-order biological differences between the sexes. ..
  12. Joint Action Analysis of Poly-drug Withdrawal
    Robert Raffa; Fiscal Year: 2006
    ..g., electrophysiologic or molecular biology techniques. An improved understanding of how withdrawal is influenced by poly-drug abuse could lead to development of enhanced clinical treatment. ..
  13. AMINOBENZOMORPHAN: POTENTIAL COCAINE ABUSE MEDICATIONS
    Mark Wentland; Fiscal Year: 2009
    ..Radioligand binding, [35S]GTPvS, and mouse antinociceptive assays will be used to characterize new targets pharmacologically. ..
  14. BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    James Zacny; Fiscal Year: 2009
    ..abstract_text> ..
  15. Separate and Combined Effects of Progesterone and Triazolam in Healthy Women
    Shanna Babalonis; Fiscal Year: 2008
    ..As such, these studies will contribute towards the development of gender-specific intervention and/or prevention strategies and health management approaches. [unreadable] [unreadable] [unreadable]..
  16. Effects of Opioid Pharmacotherapy on Functioning
    MIRIAM MINTZER; Fiscal Year: 2008
    ..Data from this project may also enhance the scientific understanding of pharmacological and cognitive mechanisms. ..
  17. Hyperthermia: Uncoupling the agony from Ecstasy
    JON SPRAGUE; Fiscal Year: 2007
    ..thyrotoxic [unreadable] crisis). [unreadable] [unreadable] [unreadable]..
  18. EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
    Samuel Stanley; Fiscal Year: 2004
    ..The CNRU will bring together a wide group of researchers providing a synergistic environment to enhance translational and clinical neuroscience research at Washington University in St. Louis. ..
  19. Addiction Treatment in Russia: Oral and Depot Naltrexone
    George Woody; Fiscal Year: 2007
    ..We hypothesize that outcomes will be better with DIN than ON, and that each will be more effective than placebo. ..
  20. Ecstasy's neurotoxicity: role of hyperthermia
    JON SPRAGUE; Fiscal Year: 2004
    ....
  21. Optimal Strategies for PID Prevention and Management
    Kenneth Smith; Fiscal Year: 2007
    ..abstract_text> ..
  22. SELF-INJURIOUS BEHAVIOR: MOLECULAR MARKERS
    DARRAGH DEVINE; Fiscal Year: 2002
    ....
  23. PERSISTENT EFFECTS OF LT/LI DRUG RISK COUNSELING
    George Woody; Fiscal Year: 2002
    ..We also believe this model of intervention has important public health significance as a sustainable, community based, early intervention for drug users. ..
  24. STUDY OF OSTEOPOROTIC FRACTURES
    Marc Hochberg; Fiscal Year: 2005
    ....
  25. Role of T Cells in Lung Disease in Systemic Sclerosis
    Marc Hochberg; Fiscal Year: 2006
    ..The new information that is gained will advance knowledge of T-cell dependent mechanisms of pulmonary fibrosis in scleroderma. ..
  26. Local Immunosuppression for Liver Transplantation
    Reza Mehvar; Fiscal Year: 2008
    ..These studies are significant because they will eventually lead to a substantial reduction in morbidity and mortality associated with the current immunosuppressive protocols used in liver transplantation. ..
  27. CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    James Zacny; Fiscal Year: 2004
    ..In short, in our two proposed series of studies, we are developing a human laboratory model of inhalant abuse by studying potential determinants of abuse liability of inhalants (volatile and gaseous) in healthy volunteers. ..
  28. Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    James P Zacny; Fiscal Year: 2010
    ..g., muscle relaxant B) would be the preferred drug to prescribe when treating chronic nonmalignant pain patients. ..
  29. Neuroimaging of Benzodiazepine-Induced Amnesia
    MIRIAM MINTZER; Fiscal Year: 2003
    ..Results of the proposed research also will enhance the understanding of the functional neuroanatomy of basic human memory processes. ..
  30. The Michigan Clinical Research Collaboratory
    Daniel Clauw; Fiscal Year: 2004
    ..Disseminate findings, tools, and strategies from this project to other re-engineered networks and Research Centers, and ultimately interface with a National Electronics Clinical Trials and Research (NECTAR) network...
  31. Benzodiazepine Use/Abuse: Effects on Memory Mechanisms
    MIRIAM MINTZER; Fiscal Year: 2008
    ..Information from this project can also be used to develop cognitive rehabilitation programs and to tailor drug abuse and anxiety treatment interventions to the specific capabilities of long-term users. ..
  32. Promoting Mental Health in the Workplace
    Debra Lerner; Fiscal Year: 2006
    ..Thus, this project will generate important information for key health care system stakeholders including consumers, purchasers, providers, and policymakers. ..
  33. Methadone maintenance and HIV risk in Ukraine
    George Woody; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  34. DEPRESSION AND PRODUCTIVE WORK ACTIVITY
    Debra Lerner; Fiscal Year: 2003
    ..Study results will contribute to the design of disability prevention and productivity improvement programs and policies. ..
  35. Stepped Care for Depression and Musculoskeletal Pain
    Kurt Kroenke; Fiscal Year: 2007
    ..Longitudinal assessment of the nondepressed cohort will establish the frequency and risk factors for incident depression. ..
  36. CHRONIC LOW BACK PAIN AS A MODEL OF FIBROMYALGIA
    Daniel Clauw; Fiscal Year: 2002
    ..abstract_text> ..
  37. 2,5 CYCLOHEXADIENONES IN NATURAL PRODUCTS SYNTHESIS
    Mark Wentland; Fiscal Year: 2001
    ....
  38. TeleCare Management of Pain and Depression in Cancer
    Kurt Kroenke; Fiscal Year: 2009
    ..Furthermore, if proven effective for depression and pain, TCM could readily be expanded to reducing barriers and improving care of other cancer-related symptoms. ..
  39. CLINICAL INVESTIGATOR TRAINING ENHANCEMENT: CITE PROGRAM
    Kurt Kroenke; Fiscal Year: 2004
    ..abstract_text> ..
  40. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..