methoxyhydroxyphenylglycol

Summary

Summary: Synthesized from endogenous epinephrine and norepinephrine in vivo. It is found in brain, blood, CSF, and urine, where its concentrations are used to measure catecholamine turnover.

Top Publications

  1. ncbi Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression
    Peter R Moult
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:2544-54. 2006
  2. ncbi Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors
    Reno Gandhi
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Brain Behav Immun 21:477-89. 2007
  3. ncbi Internalization of ionotropic glutamate receptors in response to mGluR activation
    E M Snyder
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 4:1079-85. 2001
  4. ncbi A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE 171 76, Stockholm, Sweden
    J Psychiatr Res 34:239-44. 2000
  5. ncbi Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden
    Eur Arch Psychiatry Clin Neurosci 247:297-302. 1997
  6. pmc The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation
    Yang Zhang
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:10561-6. 2008
  7. ncbi Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation
    Hita Adwanikar
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Pain 111:125-35. 2004
  8. ncbi Long-lasting synaptic loss after repeated induction of LTD: independence to the means of LTD induction
    Yuji Kamikubo
    Laboratory of Synaptic Plasticity, Osaka University Graduate School of Frontier Biosciences, Machikaneyama cho 1 1, Toyonaka, Osaka 560 0043 Japan
    Eur J Neurosci 24:1606-16. 2006
  9. pmc Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate
    Maggie W Waung
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 59:84-97. 2008
  10. ncbi Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency
    J R Shannon
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville 37232 2195, USA
    N Engl J Med 342:541-9. 2000

Research Grants

Detail Information

Publications176 found, 100 shown here

  1. ncbi Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression
    Peter R Moult
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:2544-54. 2006
    ..Together, these data suggest that activation of postsynaptic PTP results in tyrosine dephosphorylation of AMPARs and their removal from the synapse...
  2. ncbi Influence of poly I:C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors
    Reno Gandhi
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Brain Behav Immun 21:477-89. 2007
    ..Mechanisms that might be responsible for the interactive effects of social disruption and immune activation are presented, and the data were related to depressive symptoms associated with stressor and cytokine treatments...
  3. ncbi Internalization of ionotropic glutamate receptors in response to mGluR activation
    E M Snyder
    Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 4:1079-85. 2001
    ..These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking...
  4. ncbi A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE 171 76, Stockholm, Sweden
    J Psychiatr Res 34:239-44. 2000
    ..The results should be interpreted with caution until replicated because of the limited sample size...
  5. ncbi Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers
    E G Jönsson
    Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm, Sweden
    Eur Arch Psychiatry Clin Neurosci 247:297-302. 1997
    ..Due to the uncertain functional relevance of the DNA polymorphism investigated and the many calculations performed, the results should be interpreted with caution until replicated...
  6. pmc The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation
    Yang Zhang
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:10561-6. 2008
    ..Moreover, DHPG-triggered AMPAR internalization was abolished in STEP knock-out mice and restored after replacement of wild-type STEP. These results suggest a role for STEP in the regulation of AMPAR trafficking...
  7. ncbi Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation
    Hita Adwanikar
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Pain 111:125-35. 2004
    ....
  8. ncbi Long-lasting synaptic loss after repeated induction of LTD: independence to the means of LTD induction
    Yuji Kamikubo
    Laboratory of Synaptic Plasticity, Osaka University Graduate School of Frontier Biosciences, Machikaneyama cho 1 1, Toyonaka, Osaka 560 0043 Japan
    Eur J Neurosci 24:1606-16. 2006
    ..This synapse elimination should be unique as it is activity-dependent rather than inactivity-dependent...
  9. pmc Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate
    Maggie W Waung
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 59:84-97. 2008
    ..These data demonstrate a role for local Arc synthesis specifically in mGluR-LTD and suggest that mGluR-LTD may be one consequence of Arc mRNA induction during experience...
  10. ncbi Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency
    J R Shannon
    Autonomic Dysfunction Center, Department of Medicine, Vanderbilt University, Nashville 37232 2195, USA
    N Engl J Med 342:541-9. 2000
    ..We tested the hypothesis that impaired functioning of the norepinephrine transporter contributes to the pathophysiologic mechanism of orthostatic intolerance...
  11. ncbi Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls
    G Engstrom
    Department of Clinical Neuroscience, Psychiatry Section, University Hospital, Lund, Sweden
    Eur Neuropsychopharmacol 9:399-405. 1999
    ..The results suggest that low HVA levels and altered relationships between the monoamine metabolites are associated with suicidal behaviour...
  12. ncbi Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms
    J S Lee
    Department of Biomedical Sciences, Program in Neuroscience, University of Maryland Baltimore School of Dentistry, 650 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 146:375-83. 2007
    ..Thus, selective targeting of peripheral mGluR 5 and PKCalpha, as well as PKCepsilon, might serve as an effective therapeutic strategy in the management of chronic muscle pain conditions, such as temporomandibular disorders...
  13. ncbi Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels
    G P Placidi
    Center for the Study of Suicidal Behavior, Department of Neuroscience, New York State Psychiatric Institute, New York, New York, USA
    Biol Psychiatry 50:783-91. 2001
    ..The dopamine and norepinephrine systems do not appear to be as significantly involved in suicidal acts, aggression, or depression. The biological correlates of suicide intent warrant further study...
  14. ncbi Endocannabinoids contribute to short-term but not long-term mGluR-induced depression in the hippocampus
    Nathalie Rouach
    Departments of Cellular and Molecular Pharmacology and Physiology, University of California San Francisco, Genentech Hall, 600 16th Street, Box 2140, San Francisco, CA 94143, USA
    Eur J Neurosci 18:1017-20. 2003
    ..These findings suggest that endocannabinoids, acting on a non-CB1 cannabinoid receptor, contribute to the acute depression but not to DHPG-LTD. Presumably some other retrograde signalling mechanism is responsible for DHPG-LTD...
  15. ncbi Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation
    Jennifer A Ronesi
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 28:543-7. 2008
    ..Our results find specific roles for Homer in mGluR signaling and plasticity and suggest that reduced mGluR-Homer interactions in Fmr1 KO mice lead to a deficit in mGluR stimulation of translation initiation...
  16. ncbi Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area
    Manuel Mameli
    Department of Basic Neuroscience, Medical Faculty, University of Geneva, CH 1211 Geneva, Switzerland
    Science 317:530-3. 2007
    ..The synaptic insertion of GluR2 depends on de novo protein synthesis via rapid messenger RNA translation of GluR2. Regulated synthesis of GluR2 in the VTA is therefore required to reverse cocaine-induced synaptic plasticity...
  17. pmc Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:10624-38. 2010
    ..Targeting excessive PI3K activity might thus be a potent therapeutic strategy for FXS...
  18. ncbi Effects of interleukin-1beta and mild stress on alterations of norepinephrine, dopamine and serotonin neurotransmission: a regional microdialysis study
    Z Merali
    School of Psychology, University of Ottawa, Ont, Canada
    Brain Res 761:225-35. 1997
    ..These data also lend support to the contention that neurogenic stressors may have a much greater impact on central neurotransmission under conditions of immune activation...
  19. ncbi Intrapallidal metabotropic glutamate receptor activation in a rat model of Parkinson's disease: behavioral and histological analyses
    Takashi Agari
    Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan, 700 8558
    Brain Res 1203:189-96. 2008
    ..The results indicate that the blockade of amphetamine-induced rotations might be at least partially mediated by group I mGluR activation. This study advances the use of selective group I mGluRs directed toward the GP for PD treatment...
  20. ncbi Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5-dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region
    Chiung Chun Huang
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    J Neurochem 96:179-94. 2006
    ..Together, these results suggest that sustained activation of mGluR5 and in turn triggering a protein tyrosine phosphatase-dependent regulation of postsynaptic expression of AMPA receptors may contribute to the expression of DHPG-LTD...
  21. pmc N-methyl-D-aspartate receptor- and metabotropic glutamate receptor-dependent long-term depression are differentially regulated by the ubiquitin-proteasome system
    Ami Citri
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304 5552, USA
    Eur J Neurosci 30:1443-50. 2009
    ..These results suggest that, although NMDAR-dependent LTD may utilize ubiquitin as a signal for AMPAR endocytosis, mGluR-induced signaling and LTD are limited by a feedback mechanism that involves the ubiquitin-proteasome system...
  22. ncbi Reduced monoamine oxidase A activity in pregnant smokers and in their newborns
    Ivan Berlin
    Faculte de Medicine, Universite Paris 6, Hopital Pitie Salpetriere, INSERM U894, Paris, France
    Biol Psychiatry 66:728-33. 2009
    ..We aimed to compare, in everyday clinical conditions, biomarkers of MAOA activity in smoking (SPW) and lifetime nonsmoking pregnant women (NSPW) and in cord blood and to assess the newborns' behavior during the first 48 hours of life...
  23. ncbi Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression
    Lenora J Volk
    Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    J Neurophysiol 95:2427-38. 2006
    ..This suggests different receptors and/or upstream mechanisms for chemically and synaptically induced LTD...
  24. ncbi Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity
    Nancy R Keller
    Autonomic Dysfunction Center, Department of Medicine, Nashville, TN 37232 2195, USA
    Circulation 110:1191-6. 2004
    ..NET is sensitive to antidepressants, cocaine, and amphetamine. NET blockade often is associated with cardiovascular side effects, and NET deficiency is linked to tachycardia in familial orthostatic intolerance...
  25. ncbi Determination of 4-hydroxy-3-methoxyphenylethylene glycol 4-sulfate in human urine using liquid chromatography-tandem mass spectrometry
    Peyton Jacob
    Division of Clinical Pharmacology, San Francisco General Hospital Medical Center, University of California, 94110, USA
    Anal Chem 74:5290-6. 2002
    ..Precision (coefficient of variation) ranged from 1.9 to 9.7%, and accuracy ranged from 97 to 103% of expected values for controls prepared by spiking sulfatase-treated urine with MHPG sulfate...
  26. ncbi Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression
    Elena D Nosyreva
    Center for Basic Neuroscience, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 25:2992-3001. 2005
    ..The developmental switch in the synaptic mechanisms of LTD would differentially affect synapse dynamics and perhaps information processing over the course of postnatal development...
  27. ncbi Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region
    Ayako M Watabe
    Department of Physiology, UCLA School of Medicine, 53 231 Center for the Health Sciences, Los Angeles, CA 90095, USA
    J Neurophysiol 87:1395-403. 2002
    ..Together our results suggest that activation of postsynaptic mGluRs suppresses transmission at excitatory synapses onto CA1 pyramidal cells through presynaptic effects on transmitter release...
  28. ncbi Differential activation of protein kinases in the dorsal horn in vitro of normal and inflamed rats by group I metabotropic glutamate receptor subtypes
    P A Giles
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Neuropharmacology 53:58-70. 2007
    ..These actions are achieved by differential activation of PKC- and ERK-dependent transduction pathways...
  29. ncbi Metabotropic glutamate receptor-mediated depression of the slow afterhyperpolarization is gated by tyrosine phosphatases in hippocampal CA1 pyramidal neurons
    David R Ireland
    Department of Psychology, University of Otago, PO Box 56, Dunedin, New Zealand
    J Neurophysiol 92:2811-9. 2004
    ..These results suggest that the depression of the sAHP induced by activation of mGluR1 and -5 is gated by a balance between tyrosine phosphorylation and dephosphorylation...
  30. ncbi Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures
    Elena Meli
    Dipartimento di Farmacologia Preclinica e Clinica, Universita di Firenze, Viale G Pieraccini 6, I 50139 Firenze, Italy
    Neuropharmacology 49:80-8. 2005
    ..This novel pathway may contribute to the effects of mGlu1 receptors in the mechanisms leading to post-ischemic neuronal death...
  31. ncbi Hippocampal mGluR1 and consolidation of contextual fear conditioning
    Piotr Maciejak
    Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02 957, Warsaw, Poland
    Brain Res Bull 62:39-45. 2003
    ..Furthermore, they indicate that changes of glutamatergic activity within brain limbic structures can affect the threshold for the induction of the long-term neuronal plasticity, involved in some forms of learning and memory...
  32. ncbi JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1
    Xin Mei Li
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
    Eur J Neurosci 25:391-6. 2007
    ..These results demonstrated that JNK1 played a crucial role in the short-term synaptic plasticity and mGluR-dependent LTD, whereas hippocampus LTP was not affected by JNK1 deficiency...
  33. pmc Activation of mGlu receptors induces LTD without affecting postsynaptic sensitivity of CA1 neurons in rat hippocampal slices
    Gerhard Rammes
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany
    J Physiol 546:455-60. 2003
    ..These data do not support the notion that DHPG-induced LTD requires a modification of AMPA receptors, such as their internalisation, but are compatible with a presynaptic mechanism of expression...
  34. pmc Modulation of afterpotentials and firing pattern in guinea pig CA3 neurones by group I metabotropic glutamate receptors
    Steven R Young
    Department of Physiology and Pharmacology, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA
    J Physiol 554:371-85. 2004
    ....
  35. ncbi Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations
    A Heinz
    National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA
    Psychiatry Res 89:97-106. 1999
    ....
  36. ncbi DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists
    S M Fitzjohn
    Department of Anatomy, School of Medical Sciences, MRC Centre for Synaptic Plasticity, University of Bristol, UK
    Neuropharmacology 38:1577-83. 1999
    ..In conclusion, DHPG, probably via activation of mGlu5 receptors, is able to induce a robust form of LTD in the CA1 region of the young rat hippocampus that is mechanistically distinct from NMDA receptor-dependent homosynaptic LTD...
  37. ncbi Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons
    Carlo Sala
    Cellular and Molecular Pharmacology Section, Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Pharmacology, University of Milan, 20129 Milan, Italy
    J Neurosci 25:4587-92. 2005
    ....
  38. pmc mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways
    Zhao Zhong Chong
    Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, 4201 St Antoine, Detroit, Michigan 48201, USA
    Curr Neurovasc Res 2:197-211. 2005
    ..Our work defines a significant role of mGluRIs for the modulation of cellular survival and inflammation in the nervous system during oxidative stress...
  39. ncbi Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects
    Cristina Marchetti
    Biophysics Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    Eur J Neurosci 18:1873-83. 2003
    ....
  40. pmc In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression
    Brad A Grueter
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Neurosci 28:9261-70. 2008
    ..Thus, using a novel strategy of in vivo antagonist-induced rescue of ex vivo agonist effects for the same receptor, we provide evidence suggesting that mGluR5 activation is actively recruited by in vivo cocaine...
  41. ncbi Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors
    J V Selkirk
    Neurocrine Biosciences, 10555 Science Center Drive, San Diego, CA 92121, USA
    Neuropharmacology 45:885-94. 2003
    ..These results provide evidence of a role for EAATs in the regulation of mGluR5 and group III mGluRs in the rat hippocampus, which may have therapeutic implications...
  42. ncbi Genetic alteration of the alpha2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
    J Sallinen
    Orion Corporation, Orion Pharma, FIN 20101 Turku, Finland
    Mol Psychiatry 4:443-52. 1999
    ....
  43. ncbi The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides
    Feng Liu
    Wyeth Neuroscience Discovery Research, Princeton, New Jersey 08852, USA
    J Neurochem 95:1363-72. 2005
    ..Thus, these findings suggest that mGluR5 can modulate the PI3K/Akt/Gsk3beta pathway in the hippocampus, and that modulation of this signaling pathway can reverse beta-amyloid-induced neuronal toxicity...
  44. ncbi Dual modulation of gabaergic transmission by metabotropic glutamate receptors in rat ventral tegmental area
    F Zheng
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuroscience 119:453-60. 2003
    ....
  45. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..This heterosynaptic form of plasticity is involved in changes of pyramidal cell excitability associated with long-term potentiation at excitatory synapses and could account for the effects of cannabinoids on learning and memory...
  46. ncbi Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta
    E Paolucci
    Fondazione Santa Lucia IRCCS, Experimental Neurology, Via Ardeatina 306, 00179 Rome, Italy
    Eur J Neurosci 18:2743-50. 2003
    ..Our results demonstrate a powerful inhibition of the mGluR-IPSC by 5-HT in midbrain dopamine neurons, most probably through stimulation of 5-HT2A and 5-HT4 receptors...
  47. ncbi The mRNA for elongation factor 1alpha is localized in dendrites and translated in response to treatments that induce long-term depression
    Fen Huang
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, USA
    J Neurosci 25:7199-209. 2005
    ..The findings suggest that local synthesis of EF1alpha protein may be important for the synaptic mechanisms that underlie protein synthesis-dependent LTD...
  48. ncbi Expression and functional properties of group I metabotropic glutamate receptors in bovine chromaffin cells
    C Arce
    Instituto de Bioquimica, Centro Mixto CSIC UCM, Facultad de Farmacia, Madrid, Spain
    J Neurosci Res 75:182-93. 2004
    ....
  49. ncbi Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture
    M Llansola
    Laboratory of Neurobiology, Fundacion Valenciana de Investigaciones Biomedicas, Amadeo de Saboya 4, 46010 Valencia, Spain
    Neuroscience 133:185-91. 2005
    ....
  50. ncbi Activation of group I metabotropic glutamate receptors depresses recurrent inhibition of motoneurons in the neonatal rat spinal cord in vitro
    Cristina Marchetti
    Neurobiology Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014, Trieste, Italy
    Exp Brain Res 164:406-10. 2005
    ..These results suggest that, in the presence of DHPG, smaller recurrent IPSPs can contribute to the excitatory action of mGluR activation on spinal networks, including the generation of synchronous oscillations recorded from motoneurons...
  51. ncbi MGluRs regulate the expression of neuronal calcium sensor proteins NCS-1 and VILIP-1 and the immediate early gene arg3.1/arc in the hippocampus in vivo
    Marian Brackmann
    Signal Transduction Research Group, Neuroscience Research Center of the Charite, Tucholskystrasse 2, D 10117 Berlin, Germany
    Biochem Biophys Res Commun 322:1073-9. 2004
    ..Therefore, mGluRs at concentrations which induce synaptic plasticity regulate the expression of IEGs and NCS proteins in different time frames and thus contribute to late phases of synaptic plasticity...
  52. pmc NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B/calcineurin
    Sudar Alagarsamy
    Ferring Research Institute, Inc, San Diego, CA, USA
    Neuropharmacology 49:135-45. 2005
    ....
  53. ncbi Distinct properties of carbachol- and DHPG-induced network oscillations in hippocampal slices
    J Palhalmi
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43, 1083 Budapest, Hungary
    Neuropharmacology 47:381-9. 2004
    ....
  54. ncbi Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus
    Olga Poisik
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Neuropharmacology 49:57-69. 2005
    ..Therefore, our findings do not only shed light on the functions of group II mGluRs in the GP, they also illustrate the therapeutic potential of mGluR-targeting allosteric modulators in neurological disorders such as Parkinson's disease...
  55. ncbi NMDA-induced phosphorylation and regulation of mGluR5
    Sudar Alagarsamy
    Ferring Research Institute Inc, 3550 General Atomics Court, Building 2, Room 443, San Diego, CA 92121, USA
    Pharmacol Biochem Behav 73:299-306. 2002
    ....
  56. ncbi Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis
    Andrius Baskys
    Department of Mental Health, VA Health Care System, Mental Illness Research and Education Clinical Center, Long Beach, University of California at Irvine, 06 116A, 5901 East Seventh Street Long Beach, CA, 90822 Irvine, CA, USA
    Neuropharmacology 49:146-56. 2005
    ....
  57. ncbi Investigations of the protein synthesis dependency of mGluR-induced long-term depression in the dentate gyrus of freely moving rats
    Katja Naie
    Institute for Physiology of the Charite, Synaptic Plasticity Research Group, Humboldt University, Berlin, Germany
    Neuropharmacology 49:35-44. 2005
    ..Whereas AP4-induced LTD may arise as a result of modulation of presynaptic glutamate release mechanisms, the protein synthesis dependency of DHPG-induced LTD suggests an additional postsynaptic expression mechanism for this phenomenon...
  58. ncbi Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro
    Giuliano Taccola
    Neurobiology Sector and Istituto Nazionale di Fisica della Materia Unit, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    Eur J Neurosci 19:533-41. 2004
    ....
  59. ncbi Properties of long-term synaptic plasticity and metaplasticity in organotypic slice cultures of rat hippocampus
    Christian Mellentin
    Division of Neurophysiology, Department of Medical Physiology, Panum Institute, 16 5, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark
    Exp Brain Res 170:522-31. 2006
    ..We conclude that synaptic plasticity and mGluR-mediated metaplasticity are largely comparable to those effects found in acute in vitro techniques...
  60. ncbi Group I metabotropic glutamate receptor activation produces prolonged epileptiform neuronal synchronization and alters evoked population responses in the hippocampus
    Umit Sayin
    Department of Neurology, University of Wisconsin, Madison, WI, USA
    Epilepsy Res 53:186-95. 2003
    ....
  61. ncbi Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis
    Céline Vermeiren
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 96:719-31. 2006
    ..The failure of activated mGluR5 to increase glutamate uptake in astrocytes derived from this animal model of ALS supports the theory of glutamate excitotoxicity in the pathogenesis of the disease...
  62. ncbi Involvement of Na+-Ca2+ exchanger on metabotropic glutamate receptor 1-mediated [Ca2+]i transients in rat cerebellar Purkinje neurons
    Y T Kim
    Department of Physiology and Biophysics, Center for Advanced Medical Education by BK21 Project, College of Medicine, Inha University, 253, YongHyun Dong, Nam Ku, Incheon, 402 751, South Korea
    Neuroscience 146:170-7. 2007
    ..These results suggest that NCX modulates the activity of mGluR1 in cerebellar Purkinje neurons. Therefore, NCX appears to play an important role in the physiological function of cerebellar Purkinje neurons such as synaptic plasticity...
  63. ncbi Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Cell Neurosci 35:302-10. 2007
    ..In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity...
  64. ncbi FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A
    Usha Narayanan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 27:14349-57. 2007
    ..Collectively, these data reveal an immediate-early signaling pathway linking group I mGluR activity to rapid FMRP phosphorylation dynamics mediated by mTOR and PP2A...
  65. ncbi Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation
    Takako Ohno-Shosaku
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    Eur J Neurosci 15:953-61. 2002
    ..Enhancement of DSI by DHPG was also observed in hippocampal slices. These results suggest that two pathways work in a cooperative manner to release endocannabinoids via a common intracellular cascade...
  66. ncbi Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus
    Genoveva Davidkova
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 27:13273-8. 2007
    ..Together, these findings suggest that MAP1B plays a selective role in the DHPG-induced endocytosis of AMPARs, perhaps through its interaction with GRIP1...
  67. ncbi Priming stimulation of group II metabotropic glutamate receptors inhibits the subsequent induction of rat hippocampal long-term depression in vitro
    C Mellentin
    Department of Psychology, Neuroscience Research Centre, University of Otago, Box 56, Dunedin, New Zealand
    Neurosci Lett 307:13-6. 2001
    ....
  68. pmc Membrane estrogen receptor-alpha interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats
    Phoebe Dewing
    Department of Neurobiology and Laboratory of Neuroendocrinology of the Brain Research Institute, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 27:9294-300. 2007
    ..These results link membrane-initiated estradiol actions to neural events modulating behavior, demonstrating the physiological importance of ER alpha-to-mGluR1a signaling...
  69. ncbi Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus
    M Le Vasseur
    Departement de Physiologie, Groupe de Recherche sur le Système Nerveux Central, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Neuroscience 151:28-42. 2008
    ..Thus, a rich repertoire of adaptive changes may take place at these interneuron synapses to regulate hippocampal feedback inhibition...
  70. ncbi Group I metabotropic glutamate receptor-mediated calcium signalling and immediate early gene expression in cultured rat striatal neurons
    Limin Mao
    Department of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes Street, Rm M3 C225, Kansas City, Missouri 64108, USA
    Eur J Neurosci 17:741-50. 2003
    ..These results demonstrate that group I mGluRs are able to affect Ca2+ homeostasis at multiple levels and trigger Ca2+-sensitive gene transcription in striatal neurons...
  71. ncbi Metabotropic and NMDA glutamate receptor interactions with osmotic stimuli in supraoptic neurons
    Rick B Meeker
    Department of Neurology, CB 7025, 781 Burnett Womack Bldg, University of North Carolina, Chapel Hill, NC 27599, USA
    Pharmacol Biochem Behav 73:475-84. 2002
    ....
  72. ncbi Local facilitation of hippocampal metabotropic glutamate receptor-dependent long-term depression by corticosterone and dexamethasone
    Francis Chaouloff
    CNRS UMR 5091 Physiologie Cellulaire de la Synapse, Institut de Neurosciences F Magendie, Bordeaux, France
    Psychoneuroendocrinology 33:686-91. 2008
    ..These results show that high corticosterone release facilitates hippocampal CA1 mGluR-dependent LTD, and does so through local GRs...
  73. ncbi Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors
    Limin Mao
    Department of Pharmacology, School of Pharmacy, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Mol Pharmacol 62:473-84. 2002
    ....
  74. ncbi Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome
    Elena D Nosyreva
    Center for Basic Neuroscience, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9111, USA
    J Neurophysiol 95:3291-5. 2006
    ....
  75. pmc Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons
    Simon N Jacob
    Department of Pharmacology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 25:2853-64. 2005
    ..The finding that the subcellular location of initiation sites and protein microdomains was cell type specific will help to establish differences in spatiotemporal Ca2+ signaling in different types of neurons...
  76. ncbi Stimulation of group I mGlu receptors in the ventrotegmental area enhances extracellular dopamine in the rat medial prefrontal cortex
    G Renoldi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Neurochem 100:1658-66. 2007
    ..These results support the existence of functional mGlu1 and mGlu5 receptors in the VTA regulating the release of dopamine in the medial prefrontal cortex...
  77. ncbi Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria
    S Puglisi-Allegra
    Dipartimento di Psicologia, Universita La Sapienza, Rome, Italy
    Neuroreport 11:1361-4. 2000
    ..NE content and metabolism were reduced in pFC, Cg, AMY and HIP. Finally, significantly reduced DA content and metabolism was observed in pFC, NAc, CP and AMY. In pFC, NAc and CP there was also a marked reduction of DA release...
  78. pmc Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region
    Anton Sheinin
    Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD 20892 8115, USA
    J Neurophysiol 100:1041-52. 2008
    ..Comparing the present findings with earlier work in hippocampal slices and BLA, it appears that endocannabinoid release is less robust in isolated hippocampal neurons...
  79. ncbi Effects of continuous and intermittent cold (SART) stress on sympathoadrenal system activity in rats
    K Fukuhara
    Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA
    J Neuroendocrinol 8:65-72. 1996
    ..to the same extent in both 5 days SART- and continuously cold-stressed rats, whereas plasma levels of methoxyhydroxyphenylglycol (MHPG) increased only by 5 days SART stress...
  80. pmc CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy
    M Tullberg
    Institute of Clinical Neuroscience, Sahlgren s University Hospital, University of Goteborg, Sweden
    J Neurol Neurosurg Psychiatry 69:74-81. 2000
    ....
  81. ncbi Analysis of catecholamines and their metabolites in adrenal gland by liquid chromatography tandem mass spectrometry
    Qun Gu
    National Chromatographic R and A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China
    Anal Chim Acta 609:192-200. 2008
    ..The precision of the method calculated as relative standard deviation was lower than 5.3%. Deduced from the results of real sample analysis, adrenal gland synthesizes and stores the catecholamine hormones norepinephrine and epinephrine...
  82. ncbi Catecholamine monoamine oxidase a metabolite in adrenergic neurons is cytotoxic in vivo
    W J Burke
    Department of Neurology, Veterans Affairs Medical Center and Saint Louis University Medical School, St Louis, MO 63104, USA
    Brain Res 891:218-27. 2001
    ..Active uptake of the catecholamine-derived aldehyde into differentiated PC-12 cells is demonstrated. Implications of these findings for catecholamine neuron death in neurodegenerative diseases are discussed...
  83. ncbi Schedule-induced polydipsia increased both mesotelencephalic-dopaminergic and pontine-noradrenergic activities in the rat brain
    C S Tung
    Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Chin J Physiol 38:57-63. 1995
    ..We concluded that the enhanced actions of the DA-limbic system and NE-pontine system in the rats are both important for the maintenance of SIP performance...
  84. ncbi Atrial natriuretic peptide mediated alterations in catecholamine and indoleamine turnover in the nucleus of the solitary tract of rats
    B R Dev
    Department of Physiology, Health Sciences Center Faculty of Medicine, Kuwait University, Safat
    Life Sci 62:547-52. 1998
    ..Serotonin turnover was unaffected. Both norepinephrine (NE) and methoxyhydroxyphenylglycol (MHPG) levels increased, while the dihydroxyphenylacetic acid (DOPAC) level decreased, indicating the ..
  85. ncbi Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    J Neurophysiol 98:2729-36. 2007
    ..The results provide evidence that DHPG-LTD is one of the few forms of synaptic plasticity that increases with advanced age and suggest that DHPG-LTD may contribute to age-related changes in hippocampal function...
  86. ncbi Acute effects of 6-hydroxydopamine on dopaminergic neurons of the rat substantia nigra pars compacta in vitro
    Nicola Berretta
    Laboratory of Experimental Neurology, Fondazione Santa Lucia IRCCS, Via Ardeatina 306, 00179 Rome, Italy
    Neurotoxicology 26:869-81. 2005
    ....
  87. ncbi A study of the precursors of the natural antioxidant phenol 3,4-dihydroxyphenylglycol in olive oil waste
    Antonio Lama-Muñoz
    Departamento de Biotecnologia de Alimentos, Instituto de la Grasa Consejo Superior de Investigaciones Científicas, CSIC, Avda Padre Garcia Tejero, 4, 41012 Seville, Spain
    Food Chem 140:154-60. 2013
    ....
  88. ncbi Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus
    Timo Kirschstein
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 27:7696-704. 2007
    ..Thus, we conclude that the reduction of mGluR LTD after pilocarpine-induced status epilepticus is the result of the subtype-specific downregulation of mGluR5 and associated downstream signaling components...
  89. pmc Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area
    Brian E Bernier
    Section of Neurobiology and Institute for Neuroscience, Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Texas 78712, USA
    J Neurosci 31:5205-12. 2011
    ..These data suggest that repeated ethanol experience may promote the formation of drug-associated memories by enhancing synaptic plasticity of NMDARs in dopamine neurons...
  90. ncbi Association of saliva 3-methoxy-4-hydroxyphenylglycol levels and a later depressive state in older subjects living in a rural community: 3-year follow-up study
    Itaru Watanabe
    Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan
    Int J Geriatr Psychiatry 27:321-6. 2012
    ..The aim of the study was to examine the association of saliva levels of 3-methoxy-4-hydroxyphenylglycol (sMHPG) with a later depressive state in older people living in a rural community...
  91. ncbi Group I metabotropic glutamate receptors activate burst firing in rat midbrain dopaminergic neurons
    Simonetta Prisco
    IRCCS Fondazione S Lucia, Experimental Neurology Laboratory, Via Ardeatina 306, 00179 Rome, Italy
    Neuropharmacology 42:289-96. 2002
    ..These results suggest that both the activation of glutamate metabotropic type 1 and NMDA ionotropic receptors induce burst firing in the dopaminergic cells of the ventral midbrain when the activity of the SK-channels is reduced...
  92. ncbi Modulation of mGluR-dependent MAP1B translation and AMPA receptor endocytosis by microRNA miR-146a-5p
    Ying Lin Chen
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming University, Taipei 112, Taiwan, Republic of China
    J Neurosci 33:9013-20. 2013
    ..These results reveal that miR-146a-5p modulates the synaptic plasticity via repression of MAP1B protein synthesis...
  93. ncbi Association between childhood trauma and catecholamine response to psychological stress in police academy recruits
    Christian Otte
    Department of Psychiatry, University of California San Francisco, and Veterans Affairs Medical Center, San Francisco, CA, USA
    Biol Psychiatry 57:27-32. 2005
    ..Childhood trauma is a risk factor for anxiety disorders in adulthood. One possible mechanism for this association is an increased neuroendocrine response to stress in adults with a history of childhood trauma...
  94. ncbi Saliva level of free 3-methoxy-4-hydroxyphenylglycol in psychiatric outpatients with anxiety
    S Yamada
    Institute of Brain Diseases, Kurume University School of Medicine, Japan
    Int Clin Psychopharmacol 13:213-7. 1998
    ..These results indicate that the free saliva MHPG level may be a useful indicator for assessing not only the level of anxiety, but also the response to drug treatment for anxiety in these patients...
  95. ncbi Sources and significance of plasma levels of catechols and their metabolites in humans
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1620
    J Pharmacol Exp Ther 305:800-11. 2003
    ..homovanillic acid and dopamine sulfate (from dopamine), normetanephrine, vanillylmandelic acid, and methoxyhydroxyphenylglycol (from norepinephrine), and metanephrine (from epinephrine)...
  96. ncbi Association of plasma free-3-methoxy-4-hydroxyphenyl (ethylene)glycol, natural killer cell activity and delirium in postoperative patients
    J Nakamura
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Int Clin Psychopharmacol 16:339-43. 2001
    ..Furthermore, we considered that measurement of pMHPG level before operation might be a useful tool to predict the occurrence of postoperative delirium...
  97. ncbi Age-dependent differences in glutamate-induced phosphorylation systems in rat hippocampal slices
    F Angenstein
    Federal Institute for Neurobiology Magdeburg, Germany
    Hippocampus 9:173-85. 1999
    ..These data showing developmental changes in the coupling of metabotropic and ionotropic glutamate receptors to different phosphorylation systems are discussed in the light of altered physiological properties of the mature hippocampus...
  98. ncbi Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis
    Manuela Cerezo
    Department of Pharmacology, Equip of Cellular and Molecular Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Eur J Pharmacol 452:57-66. 2002
    ..High-performance liquid chromatography (HPLC) analysis of hypothalamic tissue from rats perfused with kinase inhibitors demonstrates that both calphostin-C and HA-1004 can cross the blood-brain barrier when administered peripherally...
  99. pmc Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension
    Yehonatan Sharabi
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 23:1725-32. 2008
    ..In contrast, the parasympathetic cholinergic and adrenomedullary hormonal components of the autonomic nervous system seem intact in PD+NOH...
  100. ncbi Suicide attempters: biological stressmarkers and adverse life events
    Charlotta Sunnqvist
    Department of Clinical Sciences, Psychiatry, Lund University Hospital, Kioskgatan 19, 221 85 Lund, Sweden
    Eur Arch Psychiatry Clin Neurosci 258:456-62. 2008
    ..Low 24 h U-cortisol was associated with feelings of neglect during childhood and adolescence. In conclusion, this study has shown significant and discrepant biological stress-system findings in relation to some adverse life events...
  101. ncbi Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients
    Reiji Yoshimura
    Department of Psychiatry, University of Occupational and Environmental Health 1 1Iseigaoka, Yahatanishiku, Kitakyushu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1072-7. 2007
    ..These results suggest that the enhancement of noradrenergic neurons by risperidone, which occurs independently of the two SNPs of NAT, plays a role in the clinical efficacy of the drug...

Research Grants36

  1. PSYCHOBIOLOGY OF INFANT ABUSE IN PRIMATES
    Dario Maestripieri; Fiscal Year: 2002
    ..This project will significantly enhance our understanding of the causes and consequences of infant abuse in primates and could have important implications for prevention and treatment of child maltreatment as well. ..
  2. Psychobiology of Parenting and Development
    Dario Maestripieri; Fiscal Year: 2005
    ..Finally, this research could also elucidate the mechanisms underlying individual differences in vulnerability or resilience to the effects of early abuse. ..
  3. A role for circadian clock genes in hippocampal function?
    Christopher Colwell; Fiscal Year: 2008
    ..This line of research has not been previously funded, is exploratory in nature, and thus qualifies under the R21 format. [unreadable] [unreadable] [unreadable]..
  4. NMDA Receptors and Ethanol Withdrawal Seizures
    Adam Hendricson; Fiscal Year: 2005
    ....
  5. Fluoxetine and Divalproex:Treatment Correlates in Intermittent Explosive Disorder
    EMIL COCCARO; Fiscal Year: 2007
    ..Duration of treatment will be twelve weeks. ..
  6. Links among synaptic activity, translation and structure
    Peter Vanderklish; Fiscal Year: 2003
    ....
  7. IL-6 Regulation of Hippocampal Synaptic Function
    Donna L Gruol; Fiscal Year: 2010
    ..The proposed studies focus on this issue as it relates to CNS disorders. ..
  8. MODELING THE MENOPAUSAL TRANSITION AND MENOPAUSE
    JAY KAPLAN; Fiscal Year: 2008
    ..Therefore the proposed program is directly relevant to the missions of multiple NIHInstitutes, including - butnot limited to - NIA, NICHD, NHLBI, NIDDKand NIMH. ..
  9. CYTOKINE/CHEMOKINE ACTIONS ON DEVELOPING CNS NEURONS
    DONNA GRUOL; Fiscal Year: 2002
    ....
  10. Mouse Model of Ethanol Relapse Propensity
    Roberto Melendez; Fiscal Year: 2007
    ..Research to this end could potentially lead to pharmacotherapies that might reduce relapse risk and craving states. [unreadable] [unreadable] [unreadable]..
  11. Social Information Processing: Assessment Development
    EMIL COCCARO; Fiscal Year: 2007
    ..Development of such measures is critical for the further scientific study of SIP and for its integration in neurobiologhical research. [unreadable] [unreadable]..
  12. Identification and characterization of two novel cannabinoid receptors
    Alex Straiker; Fiscal Year: 2008
    ..Marijuana is a major drug of abuse, acting via cannabinoid receptors. Knowing the identity and function of all cannabinoid receptors is key to understanding how marijuana affects the body. [unreadable] [unreadable] [unreadable]..
  13. Corticotropin Releasing Factor-Norepinephrine Interactions in Stress & Depression
    ADRIAN DUNN; Fiscal Year: 2008
    ..The results should establish a model and indicate the nature of the cerebral structures involved, so that we can subsequently test the feed-forward hypothesis [unreadable] [unreadable]..
  14. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ....
  15. QTL Mapping of Impulsivity-related Traits Before and After a Stressful Life Chang
    Lynn Fairbanks; Fiscal Year: 2009
    ..This is a novel way of assessing the role of the gene-environment interactions in measuring effects of genetic variation on behavior traits ..
  16. BEHAVIORAL TREATMENT OF MENOPAUSAL HOT FLASHES
    Robert Freedman; Fiscal Year: 2009
    ....
  17. Noradrenergic Integration of Social Information
    Keith W Sockman; Fiscal Year: 2010
    ..The predicted basis for social mediation in this model involves noradrenergic systems, which are thought to be highly conserved across vertebrates. ..
  18. Maternal Opioid Treatment: Human Experimental Research
    Susan Stine; Fiscal Year: 2009
    ..abstract_text> ..
  19. fMRI of Working Memory in the Schizophrenia Spectrum
    Harold Koenigsberg; Fiscal Year: 2007
    ..abstract_text> ..
  20. Behavioral Genetics of Impulsivity
    Lynn Fairbanks; Fiscal Year: 2005
    ....
  21. ESTROGEN EFFECTS ON ANXIETY RELATED NEURAL SYSTEMS
    Margaret Altemus; Fiscal Year: 2004
    ..This field of investigation is likely to improve understanding and treatment of anxiety and affective disorders, both of which are widely prevalent, chronic public health problems. ..
  22. Intermittent Explosive Disorder: A Family Study
    EMIL COCCARO; Fiscal Year: 2005
    ..e., relatives of IED probands with and without IED). ..
  23. Sleep Disturbance in Menopause
    Robert Freedman; Fiscal Year: 2006
    ..In Study 5, we will determine the effects of elevated sympathetic activation on HFs and sleep using a stimulus that does not, by itself, disrupt sleep (orthostasis). ..
  24. Impulsive Aggression : A Twin Study of Behavior and 5-HT
    EMIL COCCARO; Fiscal Year: 2006
    ..abstract_text> ..
  25. EFFECT OF SRIs ON GONADAL STEROIDS
    Margaret Altemus; Fiscal Year: 2006
    ..Currently, for the 30% of subjects with PMDD and OCD who do not respond to SRI treatment, there are few, if any, alternative pharmacologic strategies. ..
  26. Androgen Hormones in PMDD
    Margaret Altemus; Fiscal Year: 2007
    ..This study will also provide evidence as to whether androgen hormones, acting through androgen receptors, play a role in the pathophysiology of PMDD. ..
  27. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..
  28. PI and Wnt Signaling in Postmortem Brain of Biopolar and Schizophrenia Subjects
    Ghanshyam N Pandey; Fiscal Year: 2011
    ..This may eventually lead to i better understanding of the pathophysiology of BP or SZ illnesses and may aid in the development of more appropriate therapeutic agents for the treatment of these disorders. ..
  29. LONG-TERM LORAZEPAM USE AND ACUTE TOXICITY IN THE AGED
    Nunzio Pomara; Fiscal Year: 2005
    ..index of brain white matter organization) contribute most strongly to the acute effects of lorazepam on cognitive/motor performance or postural sway in elderly individuals receiving long-term lorazepam treatment for GAD? ..
  30. NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDS
    DONNA GRUOL; Fiscal Year: 2005
    ..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
  31. Maternal Availability and Postnatal Brain Development
    Karen Parker; Fiscal Year: 2005
    ..This animal model provides valuable insights on a basic process in human development, insofar as early emotional challenges foster adaptations useful later in life. ..
  32. Chloride cation co-transporters and hyperalgesic states
    THEODORE PRICE; Fiscal Year: 2007
    ..These hypotheses comprise an integrated series of studies that test hypotheses concerning Abeta-fiber driven pain leading to possible therapeutic strategies for the alleviation of inflammatory pain. ..
  33. PKC and Cellular Signaling in the Suicide Brain
    Ghanshyam Pandey; Fiscal Year: 2009
    ..This knowledge may aid in developing better therapeutic strategies for the treatment of suicidal behavior. ..
  34. Somatic Ca2+ Signaling in CNS Neurons
    DONNA GRUOL; Fiscal Year: 2007
    ..However, the general principles identified by the studies will also contribute significantly to our understanding of the role of activity-dependent gene expression during development in other CNS neuronal types. [unreadable] [unreadable]..
  35. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..