butylene glycols

Summary

Summary: 4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.

Top Publications

  1. ncbi Microbial 2,3-butanediol production: a state-of-the-art review
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing 210009, People s Republic of China
    Biotechnol Adv 29:351-64. 2011
  2. ncbi Fermentation of 1,3-propanediol by a lactate deficient mutant of Klebsiella oxytoca under microaerobic conditions
    Guang Yang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, No 2 Yuanmingyuan West Road, Haidian District, Beijing, 100094, People s Republic of China
    Appl Microbiol Biotechnol 73:1017-24. 2007
  3. ncbi Massive production of butanediol during plant infection by phytopathogenic bacteria of the genera Dickeya and Pectobacterium
    Géraldine Effantin
    Universite de Lyon, Universite Lyon 1, INSA Lyon, Microbiologie Adaptation et Pathogénie, CNRS UMR5240, Domaine Scientifique de la Doua, 69622 Villeurbanne, France
    Mol Microbiol 82:988-97. 2011
  4. ncbi Enantioselective synthesis of pure (R,R)-2,3-butanediol in Escherichia coli with stereospecific secondary alcohol dehydrogenases
    Yajun Yan
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 5531, Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    Org Biomol Chem 7:3914-7. 2009
  5. pmc The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-butanediol dehydrogenase
    Wayne L Nicholson
    Department of Microbiology and Cell Science, University of Florida, Kennedy Space Center, Florida 32899, USA
    Appl Environ Microbiol 74:6832-8. 2008
  6. pmc Suppressed induction of proinflammatory cytokines by a unique metabolite produced by Vibrio cholerae O1 El Tor biotype in cultured host cells
    Wasimul Bari
    Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea
    Infect Immun 79:3149-58. 2011
  7. ncbi An effective and simplified fed-batch strategy for improved 2,3-butanediol production by Klebsiella oxytoca
    Zhi Kui Nie
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing, 210009, People s Republic of China
    Appl Biochem Biotechnol 163:946-53. 2011
  8. ncbi Engineering Klebsiella oxytoca for efficient 2, 3-butanediol production through insertional inactivation of acetaldehyde dehydrogenase gene
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing 210009, People s Republic of China
    Appl Microbiol Biotechnol 85:1751-8. 2010
  9. pmc Engineering of 2,3-butanediol dehydrogenase to reduce acetoin formation by glycerol-overproducing, low-alcohol Saccharomyces cerevisiae
    Maryam Ehsani
    INRA, UMR 1083, F 34060 Montpellier, France
    Appl Environ Microbiol 75:3196-205. 2009
  10. ncbi Enhanced 2,3-butanediol production by altering the mixed acid fermentation pathway in Klebsiella oxytoca
    Xiao Jun Ji
    College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 210009, P R China
    Biotechnol Lett 30:731-4. 2008

Detail Information

Publications183 found, 100 shown here

  1. ncbi Microbial 2,3-butanediol production: a state-of-the-art review
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing 210009, People s Republic of China
    Biotechnol Adv 29:351-64. 2011
    ..The future prospects of microbial 2,3-butanediol production are discussed in light of the current progress, challenges, and trends in this field. Guidelines for future studies are also proposed...
  2. ncbi Fermentation of 1,3-propanediol by a lactate deficient mutant of Klebsiella oxytoca under microaerobic conditions
    Guang Yang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, No 2 Yuanmingyuan West Road, Haidian District, Beijing, 100094, People s Republic of China
    Appl Microbiol Biotechnol 73:1017-24. 2007
    ..56 g l-1, 0.62 mol mol-1, and 1.61 g l(-1) h-1, respectively. Furthermore, 60.11 g l(-1) 2,3-butanediol was also formed as major byproduct in the broth...
  3. ncbi Massive production of butanediol during plant infection by phytopathogenic bacteria of the genera Dickeya and Pectobacterium
    Géraldine Effantin
    Universite de Lyon, Universite Lyon 1, INSA Lyon, Microbiologie Adaptation et Pathogénie, CNRS UMR5240, Domaine Scientifique de la Doua, 69622 Villeurbanne, France
    Mol Microbiol 82:988-97. 2011
    ..These data highlight the importance of butanediol metabolism in limiting acidification of the plant tissue during the development of the soft-rot disease caused by pectinolytic enterobacteria...
  4. ncbi Enantioselective synthesis of pure (R,R)-2,3-butanediol in Escherichia coli with stereospecific secondary alcohol dehydrogenases
    Yajun Yan
    Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, 5531, Boelter Hall, 420 Westwood Plaza, Los Angeles, CA 90095, USA
    Org Biomol Chem 7:3914-7. 2009
    ..coli to produce enantiomerically pure (R,R)-2,3-butanediol (2,3-BDO) from glucose with a titer of 6.1 g/L (enantio purity >99%), and yield of 0.31 g product/g glucose (62% of theoretical maximum)...
  5. pmc The Bacillus subtilis ydjL (bdhA) gene encodes acetoin reductase/2,3-butanediol dehydrogenase
    Wayne L Nicholson
    Department of Microbiology and Cell Science, University of Florida, Kennedy Space Center, Florida 32899, USA
    Appl Environ Microbiol 74:6832-8. 2008
    ..From the data, it is proposed that the major AR/BDH-encoding gene ydjL be renamed bdhA...
  6. pmc Suppressed induction of proinflammatory cytokines by a unique metabolite produced by Vibrio cholerae O1 El Tor biotype in cultured host cells
    Wasimul Bari
    Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea
    Infect Immun 79:3149-58. 2011
    ..These results reveal a novel and potential role of 2,3-BD as an immune modulator that might have conferred a superior pathogenic potential of the El Tor over the Classical biotype...
  7. ncbi An effective and simplified fed-batch strategy for improved 2,3-butanediol production by Klebsiella oxytoca
    Zhi Kui Nie
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing, 210009, People s Republic of China
    Appl Biochem Biotechnol 163:946-53. 2011
    ..5 g/l, 1.37 g/(l•h), and 0.43 g/g obtained in glucose-feedback fed-batch strategy. This feeding strategy was simple and easy to operate and could be feasible for industrial 2,3-BD production in the future...
  8. ncbi Engineering Klebsiella oxytoca for efficient 2, 3-butanediol production through insertional inactivation of acetaldehyde dehydrogenase gene
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing 210009, People s Republic of China
    Appl Microbiol Biotechnol 85:1751-8. 2010
    ..At last, by fed-batch culturing of the mutant, the final 2,3-BD titer up to 130 g/l with the productivity of 1.63 g/l.h and the 2,3-BD yield relative to glucose of 0.48 g/g was obtained...
  9. pmc Engineering of 2,3-butanediol dehydrogenase to reduce acetoin formation by glycerol-overproducing, low-alcohol Saccharomyces cerevisiae
    Maryam Ehsani
    INRA, UMR 1083, F 34060 Montpellier, France
    Appl Environ Microbiol 75:3196-205. 2009
    ....
  10. ncbi Enhanced 2,3-butanediol production by altering the mixed acid fermentation pathway in Klebsiella oxytoca
    Xiao Jun Ji
    College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing 210009, P R China
    Biotechnol Lett 30:731-4. 2008
    ..8% more 2,3-butanediol than ME-303 with the corresponding byproducts of lactic and acetic acid decreased by 88% and 92%, respectively...
  11. pmc High yields of 2,3-butanediol and mannitol in Lactococcus lactis through engineering of NAD⁺ cofactor recycling
    Paula Gaspar
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Av Republica EAN, 2780 157 Oeiras, Portugal
    Appl Environ Microbiol 77:6826-35. 2011
    ..The theoretical yield for 2,3-butanediol was achieved. We show that FI10089ΔldhB is a valuable basis for engineering strategies aiming at the production of reduced compounds...
  12. ncbi Biocatalytic production of (2S,3S)-2,3-butanediol from diacetyl using whole cells of engineered Escherichia coli
    Lixiang Li
    State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, PR China
    Bioresour Technol 115:111-6. 2012
    ..1 g l(-1) and 26.8 g l(-1) in batch and fed-batch conversions, respectively. Thus, the process might be a promising alternative for the production of (2S,3S)-2,3-BD...
  13. ncbi Metabolic engineering of acetoin and meso-2, 3-butanediol biosynthesis in E. coli
    David R Nielsen
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biotechnol J 5:274-84. 2010
    ....
  14. pmc Cyanobacterial conversion of carbon dioxide to 2,3-butanediol
    John W K Oliver
    Department of Chemistry, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:1249-54. 2013
    ..38 g/L, which is a significant increase for chemical production from exogenous pathways in cyanobacteria. This work demonstrates that developing strong design methods can continue to increase chemical production in cyanobacteria...
  15. ncbi Deletion of lactate dehydrogenase in Enterobacter aerogenes to enhance 2,3-butanediol production
    Moo Young Jung
    Department of Chemical and Biological Engineering, Korea University, Seoul, Republic of Korea
    Appl Microbiol Biotechnol 95:461-9. 2012
    ..05 g/l 2,3-butanediol was produced in 54 h during fed-batch fermentation with the mutant. This is by far the highest titer of 2,3-butanediol with E. aerogenes achieved by metabolic pathway engineering...
  16. ncbi Elimination of carbon catabolite repression in Klebsiella oxytoca for efficient 2,3-butanediol production from glucose-xylose mixtures
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing 210009, People s Republic of China
    Appl Microbiol Biotechnol 89:1119-25. 2011
    ..This study offers a metabolic engineering strategy to achieve highly efficient utilization of sugar mixtures derived from the lignocellulosic biomass for the production of bio-based chemicals using enteric bacteria...
  17. ncbi Enhanced 2,3-butanediol production by Klebsiella oxytoca using a two-stage agitation speed control strategy
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Life Science and Pharmacy, Nanjing University of Technology, Nanjing, People s Republic of China
    Bioresour Technol 100:3410-4. 2009
    ..5 g l(-1) with the yield of 0.478 g g(-1) and the productivity of 1.71 g l(-1)h(-1), which were 6.23%, 6.22% and 22.14% over the best results controlled by constant agitation speeds...
  18. ncbi Enhanced 2,3-butanediol production by Klebsiella pneumoniae SDM
    Cuiqing Ma
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 82:49-57. 2009
    ..21 g/l h was obtained by the constant residual glucose concentration feeding strategy. To the best of our knowledge, these results were new records on BD fermentation...
  19. ncbi Microbial production of diols as platform chemicals: recent progresses
    An Ping Zeng
    Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestr 15, D 21071 Hamburg, Germany
    Curr Opin Biotechnol 22:749-57. 2011
    ..We review and discuss here the recent development in the microbial production of these diols, especially regarding the engineering of production strains and optimization of the fermentation processes...
  20. ncbi Enhanced production of 2,3-butanediol by engineered Bacillus subtilis
    Ranjita Biswas
    Organization of Advance Science and Technology, Kobe University, Kobe 657 8501, Japan
    Appl Microbiol Biotechnol 94:651-8. 2012
    ..1 g/l and overall productivity increased by 6.7-fold to 0.4 g/l h in the engineered strain compared to that in the parental control...
  21. pmc Complete genome sequence of Klebsiella oxytoca KCTC 1686, used in production of 2,3-butanediol
    Sang Heum Shin
    Macrogen Inc, Gasan Dong, Seoul, Republic of Korea
    J Bacteriol 194:2371-2. 2012
    ..The KCTC 1686 strain contains 5,974,109 bp with G+C content of 56.05 mol% and contains 5,488 protein-coding genes and 110 structural RNAs...
  22. ncbi Microbial production of 2,3-butanediol from Jerusalem artichoke tubers by Klebsiella pneumoniae
    Li Hui Sun
    Department of Bioscience and Biotechnology, School of Environmental and Biological Science and Technology, Dalian University of Technology, Linggong Road 2, 116024, Dalian, People s Republic of China
    Appl Microbiol Biotechnol 82:847-52. 2009
    ..The results showed that Jerusalem artichoke tuber is a favorable substrate for 2,3-butanediol production, and the application of fed-batch SSF for its conversion can result in a more cost-effective process...
  23. ncbi Occurrence and activity of human intestinal bacteria involved in the conversion of dietary lignans
    Thomas Clavel
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 155, 14558 Nuthetal, Germany
    Anaerobe 12:140-7. 2006
    ..In particular, Peptostreptococcus productus demethylated the lignans pinoresinol, lariciresinol and matairesinol. Finally, Eggerthella lenta catalysed the reduction of pinoresinol and lariciresinol to secoisolariciresinol...
  24. ncbi 2R,3R-butanediol, a bacterial volatile produced by Pseudomonas chlororaphis O6, is involved in induction of systemic tolerance to drought in Arabidopsis thaliana
    Song Mi Cho
    Department of Floriculture, Chunnam Techno College, Jeonnam, Korea
    Mol Plant Microbe Interact 21:1067-75. 2008
    ..We conclude that the bacterial volatile 2R,3R-butanediol was a major determinant in inducing resistance to drought in Arabidopsis through an SA-dependent mechanism...
  25. ncbi Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside
    Thomas Clavel
    Department of Gastrointestinal Microbiology, Institute of Human Nutrition Potsdam Rehbrücke, Nuthetal, Germany
    FEMS Microbiol Ecol 55:471-8. 2006
    ..The results indicate that the activation of SDG involves phylogenetically diverse bacteria, most of which are members of the dominant human intestinal microbiota...
  26. pmc Bacterial volatiles promote growth in Arabidopsis
    Choong Min Ryu
    Department of Entomology and Plant Pathology, Auburn University, 209 Life Sciences Building, Auburn, AL 36849, USA
    Proc Natl Acad Sci U S A 100:4927-32. 2003
    ....
  27. ncbi Production of 2,3-butanediol from corncob molasses, a waste by-product in xylitol production
    Ailong Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 87:965-70. 2010
    ..4%. The present study suggests that the low-cost corncob molasses could be used as an alternative substrate for the production of BD by K. pneumoniae SDM, as well as a potential carbon source for production of other high-value chemicals...
  28. pmc D-2,3-butanediol production due to heterologous expression of an acetoin reductase in Clostridium acetobutylicum
    Marco A J Siemerink
    Laboratory of Microbiology, Wageningen University and Research Centre, Dreijenplein 10, 6703 HB Wageningen, Netherlands
    Appl Environ Microbiol 77:2582-8. 2011
    ..A metabolic network that is in agreement with the experimental data is proposed. Native 2,3-butanediol production is a first step toward a potential homofermentative 2-butanol-producing strain of C. acetobutylicum...
  29. ncbi Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program
    P Foureman
    Department of Zoology, University of Wisconsin, Madison
    Environ Mol Mutagen 23:51-63. 1994
    ..Five of these, including 1,4-butanediol diglycidyl ether, 2,2-dimethyl vinyl chloride, hexamethylphosphoramide, isopropyl glycidyl ether, and urethane, also induced reciprocal translocations...
  30. ncbi Production of L-2,3-butanediol by a new pathway constructed in Escherichia coli
    S Ui
    Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Yamanashi University, Kofu, Yamanashi, Japan
    Lett Appl Microbiol 39:533-7. 2004
    ....
  31. ncbi Optimization and scale-up of 2,3-butanediol production by Bacillus amyloliquefaciens B10-127
    Taowei Yang
    The Key Laboratory of Industrial Biotechnology, Ministry of Education, Laboratory of Applied Microorganisms and Metabolic Engineering, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu Province, People s Republic of China
    World J Microbiol Biotechnol 28:1563-74. 2012
    ..4 and 0.38 g/g at 36 h with a 2,3-BD productivity of 1.71 g/l h. This result shows similar amount of 2,3-BD obtained in lab-scale fermentation, and it is possible to scale up to larger fermentors without major problems...
  32. pmc Efficient 2,3-butanediol production from cassava powder by a crop-biomass-utilizer, Enterobacter cloacae subsp. dissolvens SDM
    Ailong Wang
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    PLoS ONE 7:e40442. 2012
    ..2,3-Butanediol (BD) is considered as one of the key platform chemicals used in a variety of industrial applications. It is crucial to find an efficient sugar-utilizing strain and feasible carbon source for the economical production of BD...
  33. ncbi Microbial production of meso-2,3-butanediol by metabolically engineered Escherichia coli under low oxygen condition
    Zheng Jun Li
    Department of Biology, Tsinghua University, Beijing, China
    Appl Microbiol Biotechnol 87:2001-9. 2010
    ..43 g BD/g glucose for the mixed acid pathway deleted mutant grown in fermentors under 1% DO. These results reveals the potential of production of enantiomerically pure 2,3-BD isomer by recombinant E. coli under low oxygen condition...
  34. pmc Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG)
    Melpo Christofidou-Solomidou
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Radiat Res 178:568-80. 2012
    ..The dietary lignan complex of FS, mainly consisting of the phenolic secoisolariciresinol, is protective against radiation pneumonopathy in vivo while not hindering the tumoricidal effects of radiotherapy...
  35. ncbi Blood and urinary levels of ethanol, acetaldehyde, and C4 compounds such as diacetyl, acetoin, and 2,3-butanediol in normal male students after ethanol ingestion
    M Otsuka
    Faculty of Pharmaceutical Sciences, Okayama University, Japan
    Alcohol 17:119-24. 1999
    ..The student with the inactive form of ALDH2 was flushed and his levels of 2,3-butanediol and acetaldehyde in blood and urine were found to be the highest...
  36. ncbi Production of 2,3-butanediol by a low-acid producing Klebsiella oxytoca NBRF4
    Sung Hyuk Han
    Department of Advanced Fermentation Fusion Science and Technology, Kookmin University, Seoul 136 702, Republic of Korea
    N Biotechnol 30:166-72. 2013
    ..Finally, 34.2g/L 2,3-BDO concentration and 0.35 g/g yield were obtained without organic acid production in 70 hours of the fed-batch culture, which were 2.4 and 1.2 times higher than those of the batch fermentation using 44 g/L glucose...
  37. ncbi Microbial production of 2,3-butanediol by a surfactant (serrawettin)-deficient mutant of Serratia marcescens H30
    Liaoyuan Zhang
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, People s Republic of China
    J Ind Microbiol Biotechnol 37:857-62. 2010
    ..Ultimately, fed-batch culturing of the mutant afforded a maximum 2,3-BD concentration of 152 g l(-1) with a productivity of 2.67 g l(-1) h(-1) and a yield of 92.6% at 57 h...
  38. ncbi Production of 2,3-butanediol from glucose by GRAS microorganism Bacillus amyloliquefaciens
    Taowei Yang
    The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu Province 214122, PR China
    J Basic Microbiol 51:650-8. 2011
    ..3 g/l at 96 h with a 2,3-BD productivity of 0.96 g/l h. To our knowledge, the results were new records on 2,3-BD fermentation by Bacillus, which shown an excellent candidate for the microbial fermentation of 2,3-BD on an industrial scale...
  39. ncbi Influence of blocking of 2,3-butanediol pathway on glycerol metabolism for 1,3-propanediol production by Klebsiella oxytoca
    Gang Zhang
    State Key Laboratory for Agrobiotechnology, China Agricultural University, No 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, People s Republic of China
    Appl Biochem Biotechnol 168:116-28. 2012
    ..The assay of the enzyme activities in the oxidative branch and the reductive branch of the glycerol metabolism, as well as the intracellular redox state, exposited the results logically...
  40. ncbi Enhanced production of 2,3-butanediol from glycerol by forced pH fluctuations
    Kaloyan Petrov
    Institute of Chemical Engineering, Bulgarian Academy of Sciences, 103, Acad G Bonchev Str, 1113, Sofia, Bulgaria
    Appl Microbiol Biotechnol 87:943-9. 2010
    ..The forced pH fluctuations emphasized pH as a governing factor in microbial conversion processes...
  41. ncbi Biotechnological production of 2,3-butanediol--current state and prospects
    E Celinska
    Poznan University of Life Sciences, Department of Biotechnology and Food Microbiology, Wojska Polskiego 48, 60 627 Poznan, Poland
    Biotechnol Adv 27:715-25. 2009
    ....
  42. ncbi Activity of male pheromone of Melanesian rhinoceros beetle Scapanes australis
    Didier Rochat
    INRA, Unite de Phytopharmacie et Mediateurs Chimiques, Centre de Versailles, France
    J Chem Ecol 28:479-500. 2002
    ..The captures followed a log-linear decrease during the 125-week trapping program. The role of the male pheromone and its potential for crop protection are discussed...
  43. pmc Genome sequence of Enterobacter cloacae subsp. dissolvens SDM, an efficient biomass-utilizing producer of platform chemical 2,3-butanediol
    Youqiang Xu
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, People s Republic of China
    J Bacteriol 194:897-8. 2012
    ..9-Mb assembly of its genome. The key genes for regulation and metabolism of 2,3-butanediol production were annotated, which could provide further insights into the molecular mechanism of high-yield production of 2,3-butanediol...
  44. ncbi Biological production of 2,3-butanediol
    M J Syu
    Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan, ROC
    Appl Microbiol Biotechnol 55:10-8. 2001
    ..On-line analysis, modeling, and control of BDL fermentation are discussed. In addition, downstream recovery of 2,3-BDL and the integrated process (being important issues of BDL production) are also introduced...
  45. pmc Novel (2R,3R)-2,3-butanediol dehydrogenase from potential industrial strain Paenibacillus polymyxa ATCC 12321
    Bo Yu
    Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, 21071 Hamburg, Germany
    Appl Environ Microbiol 77:4230-3. 2011
    ..The results showed that BDH99::67 belongs to the medium-chain dehydrogenase/reductase superfamily and not to the short-chain dehydrogenase/reductase superfamily, to which meso- and (2S,3S)-2,3-butanediol dehydrogenases belong...
  46. ncbi Development of an industrial medium for economical 2,3-butanediol production through co-fermentation of glucose and xylose by Klebsiella oxytoca
    Xiao Jun Ji
    State Key Laboratory of Materials Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No 5 Xinmofan Road, Nanjing 210009, People s Republic of China
    Bioresour Technol 100:5214-8. 2009
    ....
  47. ncbi Quorum sensing and butanediol fermentation affect colonization and spoilage of carrot slices by Serratia plymuthica
    Eva Wevers
    Laboratory of Food Microbiology and Leuven Food Science and Nutrition Research Centre LFoRCe, Department of Microbial and Molecular Systems M2S, Katholieke Universiteit Leuven, Kasteelpark Arenberg 23, 3001 Leuven, Belgium
    Int J Food Microbiol 134:63-9. 2009
    ....
  48. ncbi Production of 2,3-butanediol by newly isolated Enterobacter cloacae
    B C Saha
    National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, IL 61604, USA
    Appl Microbiol Biotechnol 52:321-6. 1999
    ..35 g/g available sugars). It also produced BD from dilute acid pretreated corn fiber by simultaneous saccharification and fermentation (0.34 g/g theoretical sugars)...
  49. ncbi Effects of temperature, inoculum size and starch hydrolyzate concentration on butanediol production by Bacillus licheniformis
    P Perego
    Department of Chemical and Process Engineering, University of Genoa, Via Opera Pia 15, 16145 Genoa, Italy
    Bioresour Technol 89:125-31. 2003
    ..licheniformis. Therefore, cornstarch hydrolyzate can be proposed as an alternative carbon source for industrial production of 2,3-butanediol with no need for growth factor addition...
  50. pmc Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screening
    Jonas M Bengtsson
    Department of Plant Protection Biology, Swedish University of Agricultural Sciences, Alnarp, Sweden
    J Chem Ecol 35:1063-76. 2009
    ..Field trapping results revealed that racemic 2,3-butanediol is a powerful novel attractant for P. interrupta...
  51. pmc Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans
    Thomas Clavel
    German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 155, 14558 Nuthetal, Germany
    Appl Environ Microbiol 71:6077-85. 2005
    ..productus and related species (P = 0.012), as well as bacteria belonging to the Atopobium group (P = 0.035), were typical of individuals with moderate to high concentrations of EL-producing communities...
  52. ncbi Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside
    Thomas Clavel
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Arthur Scheunert Allee 155, 14558 Nuthetal, Germany
    Syst Appl Microbiol 30:16-26. 2007
    ..0 mol%). According to these findings, it is proposed to create a novel genus, Lactonifactor, and a novel species, Lactonifactor longoviformis, to accommodate strain ED-Mt61/PYG-s6. The type strain is DSM 17459T (=CCUG 51487T)...
  53. ncbi Male-specific EAD active compounds produced by female European chafer Rhizotrogus majalis (Razoumowsky)
    Satoshi Nojima
    Department of Entomology, NYS Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    J Chem Ecol 29:503-7. 2003
    ..No behavioral role for any of the EAD active compounds could be discerned with this species...
  54. ncbi Purification and characterization of a biodegradable plastic-degrading enzyme from Aspergillus oryzae
    Hiroshi Maeda
    Tohoku Technoarch, 2 1 1 Katahira, Aoba ku, Sendai, 980 8577, Japan
    Appl Microbiol Biotechnol 67:778-88. 2005
    ..Determination of the affinities for different chemicals indicated that the most preferred substrate for the enzyme would consist of butyric acid and n-hexanol...
  55. ncbi The bacterial metabolite 2,3-butanediol ameliorates endotoxin-induced acute lung injury in rats
    Shang Chen Hsieh
    Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei 100, Taiwan, ROC
    Microbes Infect 9:1402-9. 2007
    ..These results indicate that bacterial metabolite, 2,3-butanediol has a negative regulatory effect on host innate immunity response, suggesting bacteria may use some metabolites for host immune evasion...
  56. ncbi Structural basis for chiral substrate recognition by two 2,3-butanediol dehydrogenases
    Masato Otagiri
    Laboratory of Environmental Molecular Biology, RIKEN, Tsurumi ward, Kanagawa, Japan
    FEBS Lett 584:219-23. 2010
    ..This result confirms the importance of conserved residues in modifying the stereospecificity of homologous enzymes...
  57. ncbi Reversal of coenzyme specificity of 2,3-butanediol dehydrogenase from Saccharomyces cerevisae and in vivo functional analysis
    Maryam Ehsani
    INRA, UMR 1083, 2 place Viala, F 34060 Montpellier, France
    Biotechnol Bioeng 104:381-9. 2009
    ..In addition, they represent promising tools for the manipulation of the NADP(H) metabolism and for the development of a powerful catalyst in biotransformations requiring NADPH regeneration...
  58. pmc Bacterial volatiles induce systemic resistance in Arabidopsis
    Choong Min Ryu
    Department of Entomology and Plant Pathology, Auburn University, 209 Life Sciences Building, Auburn, Alabama 36849, USA
    Plant Physiol 134:1017-26. 2004
    ..This study provides new insight into the role of bacteria VOCs as initiators of defense responses in plants...
  59. ncbi Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria
    Jong Sik Jin
    Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
    Biol Pharm Bull 30:2113-9. 2007
    ..However, the bacterium could not transform (+)-DHEND (3a) and (-)-DHENL (4b). Both bacterial strains demonstrated different enantioselective dehydroxylation...
  60. ncbi Assessing exposure to lignans and their metabolites in humans
    Johanna W Lampe
    Fred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA 98109, USA
    J AOAC Int 89:1174-81. 2006
    ....
  61. ncbi Medical and legal confusion surrounding gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD)
    D M Wood
    Guy s and St Thomas Poisons Unit, Guy s and St Thomas NHS Foundation Trust, Avonley Road, London, UK
    QJM 101:23-9. 2008
    ..However, its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD) remain legally available despite having similar clinical effects...
  62. ncbi Effect of processing and storage on the stability of flaxseed lignan added to dairy products
    Helena K Hyvärinen
    Biotechnology and Food Research, MTT Agrifood Research Finland, FIN 31600 Jokioinen, Finland
    J Agric Food Chem 54:8788-92. 2006
    ..Up to 25% of added SDG was lost in whey-based drinks during storage of 6 months at 8 degrees C. We conclude that SDG can be successfully supplemented in dairy-based products...
  63. ncbi Lignan profile in seeds of modern and old Italian soft wheat (Triticum aestivum L.) cultivars as revealed by CE-MS analyses
    Giovanni Dinelli
    Department of Agroenvironmental Science and Technology, University of Bologna, Bologna, Italy
    Electrophoresis 28:4212-9. 2007
    ..Results highlighted the high content and unique composition in lignans of old cultivars suggesting their uses into a wide range of regular and specialty food products naturally enriched with health-promoting compounds...
  64. ncbi Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review
    Jeremy M Wojtowicz
    Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada
    CJEM 10:69-74. 2008
    ..Emergency physicians must consider withdrawal from these agents when patients present with clinical features suggestive of a sedative-hypnotic withdrawal syndrome...
  65. ncbi Contribution of linseed intake to urine and serum enterolignan levels in German females: a randomised controlled intervention trial
    U Knust
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Food Chem Toxicol 44:1057-64. 2006
    ..In the control group enterolignan levels were raised slightly but did not reach significance. Serum and urinary enterolignans of the whole collective showed a good pairwise correlation...
  66. ncbi Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia
    Wei Zhang
    Tumor Hospital and Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    J Med Food 11:207-14. 2008
    ....
  67. ncbi Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats
    Niina M Saarinen
    Functional Foods Forum, University of Turku, Turku, Finland
    Int J Cancer 123:1196-204. 2008
    ..These findings indicate conceivable importance of dietary lignan lariciresinol in inhibition of breast cancer development...
  68. ncbi Hinokinin biosynthesis in Linum corymbulosum Reichenb
    Urün Bayindir
    Institut für Entwicklungs und Molekularbiologie der Pflanzen, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, D 40225 Dusseldorf, Germany
    Plant J 55:810-20. 2008
    ..Our results strongly indicate that PLR-Lc1 participates in (-)-hinokinin biosynthesis in L. corymbulosum by the first of the two hypothetical pathways via (-)-secoisolariciresinol...
  69. ncbi Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats
    Lisa E Baker
    Department of Psychology, Western Michigan University, Kalamazoo, MI 49008, United States
    Pharmacol Biochem Behav 89:598-607. 2008
    ..These findings are consistent with previous reports of GHB's discriminative stimulus effects in two-choice drug discrimination procedures and provide additional evidence that these effects are distinct from those of ethanol...
  70. ncbi AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG
    Farah S Hosseinian
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada
    Org Biomol Chem 5:644-54. 2007
    ..Finally, SECO is a superior antioxidant to SDG, and it may be that the additional alcohol oxidation pathway contributes to its greater antioxidant ability...
  71. pmc An interactive lesson in acid/base and pro-drug chemistry using sodium gamma-hydroxybutyrate and commercial test coasters
    Nathaniel A Page
    School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, NY 14260, USA
    Am J Pharm Educ 71:54. 2007
    ....
  72. ncbi Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro
    Chun Hu
    Food, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC, Canada V6T 1Z4
    Food Chem Toxicol 45:2219-27. 2007
    ..These represent likely extra- and intracellular antioxidant activities of flax-derived lignans at concentrations potentially achievable in vivo...
  73. ncbi Gamma-Hydroxybutyrate (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) reduce the volume of cerebral infarction in rodent transient middle cerebral artery occlusion
    Shankar Sadasivan
    Division of Pediatric Emergency Medicine, Rainbow Babies and Children s Hospital Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 1074:537-44. 2006
    ..7, and 275.4 +/- 39.9 cu.mm for rats treated with 1,4-BD (P < 0.05), GBL (P < 0.05), and GHB (P < 0.05), respectively. We conclude that GHB, GBL, and 1,4-BD protect against rat focal cerebral ischemia from transient MCAO...
  74. ncbi Determination of gamma-hydroxybutyrate (GHB) and its precursors in blood and urine samples: a salting-out approach
    Aino Kankaanpää
    Drug Research Unit, Department of Mental Health and Alcohol Research, National Public Health Institute, Mannerheimintie 166, Helsinki, Finland
    Forensic Sci Int 170:133-8. 2007
    ..As revealed by the validation data this procedure is suitable for quantitative determination of GHB and its precursors in blood and/or urine samples...
  75. ncbi Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats
    Lawrence P Carter
    The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive MC7764, San Antonio, TX 78229, USA
    Eur J Neurosci 24:2595-600. 2006
    ....
  76. ncbi Secoisolariciresinol and matairesinol of sea buckthorn (Hippophaë rhamnoides L.) berries of different subspecies and harvesting times
    Baoru Yang
    Department of Biochemistry and Food Chemistry, University of Turku, FIN 20014 Turku, Finland
    J Agric Food Chem 54:8065-70. 2006
    ..Harvesting dates had a significant influence on the content of the two lignans in seeds, fruit pulp/peel, and whole berries. This is the first report of lignans in sea buckthorn...
  77. ncbi Flax lignans--analytical methods and how they influence our lunderstanding of biological activity
    Alister D Muir
    Agriculture and Agri Food Canada, 107 Science P1, Saskatoon, SK, Canada S7N 0X2
    J AOAC Int 89:1147-57. 2006
    ....
  78. ncbi Pinoresinol-lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax (Linum usitatissimum) seeds
    C Hano
    Laboratoire de Biologie des Ligneux et des Grandes Cultures, UPRES EA 1207, Antenne Scientifique Universitaire de Chartres, 21 rue de Loigny la Bataille, 28000, Chartres, France
    Planta 224:1291-301. 2006
    ....
  79. ncbi Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Mol Cell Biochem 270:139-45. 2005
    ..It is concluded that chronic use of lignan complex had no adverse effects on the hemopoietic system...
  80. ncbi The role of GABAB receptors in the discriminative stimulus effects of gamma-hydroxybutyrate in rats: time course and antagonism studies
    Lawrence P Carter
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 305:668-74. 2003
    ..That NCS-382 shares effects with GHB could explain the lack of antagonism reported for NCS-382 in some studies...
  81. ncbi Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam
    Wouter Koek
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, Mail Code 7792, San Antonio, TX 78229 3900, USA
    J Pharmacol Exp Ther 314:170-9. 2005
    ..Effects that GHB does not share with baclofen may involve GHB receptors or differential interactions with GABA(B) receptors...
  82. ncbi GC/MS profiling of gamma-hydroxybutyrate and precursors in various animal tissues using automatic solid-phase extraction. Preliminary investigations of its potential interest in postmortem interval determination
    Damien Richard
    Laboratoire de Toxicologie, Faculte de Pharmacie, Institut Régional de Médecine Légale, CHU G Montpied, 63000 Clermont Ferrand, France
    Anal Chem 77:1354-60. 2005
    ..Preliminary results show a linear increase of GHB levels in relation to time of death in thoracic blood and central nervous system of animals kept at 15 and 20 degrees C...
  83. ncbi Lignans in resin of Araucaria angustifolia by gas chromatography/mass spectrometry
    Shuichi Yamamoto
    Environmental and Petroleum Geochemistry Group, College of Oceanic and Atmospheric Sciences, Oregon State University, Corvallis, Oregon 97331, USA
    J Mass Spectrom 39:1337-47. 2004
    ..The mass spectra of the various lignan trimethylsilyl derivatives are discussed with the interpretations of the fragmentation patterns...
  84. ncbi Intake of lignans is associated with serum enterolactone concentration in Finnish men and women
    Annamari Kilkkinen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Nutr 133:1830-3. 2003
    ..2 mg). The main dietary sources of lignans, i.e., whole grain, vegetables and fruits, are foods commonly associated with lower risk of cardiovascular diseases and cancer. Serum EL concentration is a feasible biomarker of lignan intake...
  85. ncbi Gamma-butyrolactone and 1,4-butanediol: abused analogues of gamma-hydroxybutyrate
    Robert B Palmer
    Toxicology Associates, Prof LLC, Denver, Colorado, USA
    Toxicol Rev 23:21-31. 2004
    ..This review examines the history of GHB analogue abuse as well as the clinical presentation and management of acute intoxication and withdrawal associated with abuse of these compounds...
  86. ncbi Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis
    Jianmin Chen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Exp Biol Med (Maywood) 228:951-8. 2003
    ....
  87. ncbi Secoisolariciresinol and isotaxiresinol inhibit tumor necrosis factor-alpha-dependent hepatic apoptosis in mice
    Arjun H Banskota
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Life Sci 74:2781-92. 2004
    ....
  88. ncbi Influence of reinforcer type and route of administration on gamma-hydroxybutyrate discrimination in rats
    Lisa E Baker
    Department of Psychology, Western Michigan University, Kalamazoo, MI 49008, USA
    Psychopharmacology (Berl) 174:220-7. 2004
    ..Possible effects of reinforcer type on the results of drug discrimination studies have not been examined systematically, but different deprivation operations and differentially effective reinforcers might well influence outcomes...
  89. ncbi Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats
    Kah Poh Tan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto 150 College Street, Toronto, Ontario M5S 3E2, Canada
    Exp Biol Med (Maywood) 229:147-57. 2004
    ..The physiological outcomes of FS and SDG were similar, which suggests that SDG is partly responsible for the mammary gland differentiation effect...
  90. ncbi Dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii
    Na Li
    Department of Chemistry and Chemical Engineering, Niigata University, 8050, 2 Nocho, Ikarashi, Niigata 950 2181, Japan
    J Nat Prod 66:1421-6. 2003
    ..The absolute structures were elucidated as 2S,3S from their optical rotations and by chemical transformations...
  91. ncbi Studies on the metabolism of the plant lignans secoisolariciresinol and matairesinol
    Heike B Niemeyer
    Institute of Food Chemistry and Toxicology, Department of Chemistry and Biosciences, University of Karlsruhe, P O Box 6980, 76128 Karlsruhe, Germany
    J Agric Food Chem 51:6317-25. 2003
    ....
  92. ncbi High-performance liquid chromatographic analysis of secoisolariciresinol diglucoside and hydroxycinnamic acid glucosides in flaxseed by alkaline extraction
    Christina Eliasson
    Department of Food Science, Swedish University of Agricultural Sciences SLU, P O Box 7051, SE 750 07 Uppsala, Sweden
    J Chromatogr A 1012:151-9. 2003
    ..On dry matter basis, different samples of flaxseeds varied considerably in their content of (+)-SDG (11.9-25.9 mg/g), (-)-SDG (2.2-5.0 mg/g), p-coumaric acid glucoside (1.2-8.5 mg/g), and ferulic acid glucoside (1.6-5.0 mg/g)...
  93. ncbi Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinol
    Ivon E J Milder
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Br J Nutr 93:393-402. 2005
    ..Thus, available databases largely underestimate the amount of enterolignan precursors in foods...
  94. ncbi Lignans from bark of Larix olgensis var. koreana
    Bao Hua Yang
    Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai 200433, People s Republic of China
    J Nat Prod 68:1175-9. 2005
    ..Compound 1 showed weak inhibition against K562, SHG44, HCT-8, A549, and PC-3M tumor cells with IC50 values of 2.9, 21.4, 32.9, 33.8, and 28.0 microg/mL, respectively...
  95. ncbi Determination of secoisolariciresinol, lariciresinol and isolariciresinol in plant foods by high performance liquid chromatography coupled with coulometric electrode array detection
    Heidi Schwartz
    Department of Analytical Chemistry and Food Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, A 1090 Vienna, Austria
    J Chromatogr B Analyt Technol Biomed Life Sci 838:78-85. 2006
    ..In addition, investigation of various foodstuffs involving enzymatic hydrolysis with and without preceding methanolysis showed that the degree of esterification of lignans in plant foods is species dependent...
  96. ncbi Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucoside-hydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed
    J D Ford
    Institute of Biological Chemistry, Washington State University, Pullman, Washington 99164-6340, USA
    J Nat Prod 64:1388-97. 2001
    ..Results from this study will facilitate future isolation and characterization of the proteins and enzymes involved in biosynthesis of the SDG-HMG ester-linked oligomers in flax seed...
  97. ncbi Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem
    Ellen Eeckhaut
    Laboratory of Microbial Ecology and Technology LabMET, Faculty of Bioscience Engineering, Ghent University Ugent, Coupure Links 653, B 9000 Gent, Belgium
    J Agric Food Chem 56:4806-12. 2008
    ..Enterolignan phenotypes remained stable throughout the experimental period. The establishment of END and ENL production equilibria reflected the subdominance of ENL-producing bacteria in the gastrointestinal tract...
  98. ncbi On-line liquid-chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry coupling for the separation and characterization of secoisolariciresinol diglucoside isomers in flaxseed
    J Fritsche
    Unilever Research and Development, Vlaardingen, The Netherlands
    J Chromatogr A 972:195-203. 2002
    ..Circular dichroism (CD) analyses confirmed the presence of two distinguished optically active compounds present in the flaxseed extract...
  99. ncbi Effect of processing and storage on the stability of flaxseed lignan added to bakery products
    Helena K Hyvärinen
    Food Research, MTT Agrifood Research Finland, FIN 31600 Jokioinen, Finland
    J Agric Food Chem 54:48-53. 2006
    ..Similarly, the content of SDG in flax buns containing fat-free flaxseed meal was unaffected by storage. We conclude that cereal-based bakery products can be supplemented with flaxseed-derived SDG...
  100. ncbi Isolation of the lignan secoisolariciresinol diglucoside from flaxseed (Linum usitatissimum L.) by high-speed counter-current chromatography
    Andreas Degenhardt
    Institute of Food Chemistry, Technical University of Braunschweig, Germany
    J Chromatogr A 943:299-302. 2002
    ..butylmethyl ether-n-butanol-acetonitrile-water (1:3:1:5). The purity and identity of the isolated compound was checked by high-performance liquid chromatography analysis in combination with mass spectrometry and NMR measurements...
  101. ncbi Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components
    A H Banskota
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Phytomedicine 13:109-14. 2006
    ..4% and 20.9%, respectively. The blood glucose lowering effects of 1 and 2 were stronger than the mixture of tolbutamide (200mg/kg) and buformin (1mg/kg) used as a positive control, which lowered fasting blood glucose level by 24.0%...

Research Grants25

  1. Toxicokinetics and Toxicodynamics of GHB and Precursors
    Ho Leung Fung; Fiscal Year: 2004
    ..A pharmacogenetic mapping of the pharmacological effects of GHB will be obtained. The effects of tolerance development, withdrawal, gender, receptor blockade on these effects will be examined. ..
  2. Self-administration of GHB, GBL and 1,4-BD in baboons
    AMY GOODWIN; Fiscal Year: 2005
    ..The results of the proposed study will characterize the abuse liability of GHB, GBL, and 1,4-BD by use of a well-established method of abuse liability testing in non-human primates. ..
  3. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  4. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  5. Flourescent Ceramic Nanoprobes (RMI)
    TIMOTHY BOYLE; Fiscal Year: 2008
    ..All of the innovations uncovered during the preparation of these nanoprobes will be shared in order to benefit medical research applications beyond those proposed in this investigation. ..
  6. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  7. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  8. FlaxSeed Lignan for Breast Cancer Chemoprevention
    CAROL FABIAN; Fiscal Year: 2007
    ..If positive, the results of this study will be critical to the design and implementation of a placebo-controlled Phase II prevention trial with Brevail and/or commercial flaxseed. [unreadable] [unreadable]..
  9. Breast Cancer Risk Biomarkers and Energy Balance
    CAROL FABIAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  11. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  12. Children's exposures/health effects/diesel exhaust
    LEE JANE LIU; Fiscal Year: 2008
    ..This study will provide critical missing information relating reductions in diesel emissions directly to reductions in exposures and health effects. ..
  13. Organic Nitrate Metabolism, Tolerance and Action
    Ho Leung Fung; Fiscal Year: 2010
    ..believe that our studies can provide new and meaningful data that will contribute to the establishment of a unifying mechanism for organic nitrate action and deleterious effects, and lead to their better therapeutic use ..
  14. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  15. Mouse model of binge drinking-induced neurotoxicity
    CHRISTOPHER DE FIEBRE; Fiscal Year: 2006
    ..Via the latter, the development of alpha7-selective agents as therapeutics to treat binge drinking-induced neurotoxicity may be fostered. ..
  16. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  17. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  18. CHEMOPREVENTION FOR WOMEN AT HIGH RISK OF BREAST CANCER
    CAROL FABIAN; Fiscal Year: 2003
    ..The answer impacts on the entire future of breast cancer chemoprevention development efforts. ..
  19. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  20. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  21. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  22. Breast Cancer Prevention by Letrozole in High Risk Women
    Carol J Fabian; Fiscal Year: 2010
    ....
  23. Toxicokinetics and Toxicodynamics of Nitrite Inhalants
    Ho Leung Fung; Fiscal Year: 2005
    ..We believe that our proposal represents novel approaches toward the understanding of nitrite inhalant toxicity in vivo. ..
  24. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  25. GHB: Discrimination and effects on learning
    Lisa Baker; Fiscal Year: 2003
    ..Behavior under these assays is sensitive to other abused drugs. Therefore, these assays may be of value in characterizing the effects of GHB. ..