ethanol

Summary

Summary: A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.

Top Publications

  1. pmc Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis
    Steve Swinnen
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven Heverlee, Flanders, Belgium
    Genome Res 22:975-84. 2012
  2. pmc A molecular mechanism of chronological aging in yeast
    Christopher R Burtner
    Department of Biochemistry, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Cell Cycle 8:1256-70. 2009
  3. ncbi Hydrolysis of lignocellulosic materials for ethanol production: a review
    Ye Sun
    Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh 27695 7625, USA
    Bioresour Technol 83:1-11. 2002
  4. pmc Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass
    Chunxiang Fu
    Forage Improvement Division and Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, OK 73401, USA
    Proc Natl Acad Sci U S A 108:3803-8. 2011
  5. ncbi Challenges in engineering microbes for biofuels production
    Gregory Stephanopoulos
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:801-4. 2007
  6. ncbi Features of promising technologies for pretreatment of lignocellulosic biomass
    Nathan Mosier
    Laboratory of Renewable Resources Engineering, Department of Agricultural and Biological Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907 2022, USA
    Bioresour Technol 96:673-86. 2005
  7. ncbi Biomass recalcitrance: engineering plants and enzymes for biofuels production
    Michael E Himmel
    Chemical and Biosciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA
    Science 315:804-7. 2007
  8. ncbi Molecular mechanisms of alcohol-mediated carcinogenesis
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, University of Heidelberg, Heidelberg, Germany
    Nat Rev Cancer 7:599-612. 2007
  9. ncbi Ethanol modulation of intestinal epithelial tight junction barrier
    T Y Ma
    Division of Gastroenterology, Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach 90822, USA
    Am J Physiol 276:G965-74. 1999
  10. pmc Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:15218-23. 2003

Detail Information

Publications382 found, 100 shown here

  1. pmc Identification of novel causative genes determining the complex trait of high ethanol tolerance in yeast using pooled-segregant whole-genome sequence analysis
    Steve Swinnen
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Leuven Heverlee, Flanders, Belgium
    Genome Res 22:975-84. 2012
    High ethanol tolerance is an exquisite characteristic of the yeast Saccharomyces cerevisiae, which enables this microorganism to dominate in natural and industrial fermentations...
  2. pmc A molecular mechanism of chronological aging in yeast
    Christopher R Burtner
    Department of Biochemistry, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Cell Cycle 8:1256-70. 2009
    ..We conclude that acetic acid induced mortality is the primary mechanism of chronological aging in yeast under standard conditions...
  3. ncbi Hydrolysis of lignocellulosic materials for ethanol production: a review
    Ye Sun
    Department of Biological and Agricultural Engineering, North Carolina State University, Raleigh 27695 7625, USA
    Bioresour Technol 83:1-11. 2002
    Lignocellulosic biomass can be utilized to produce ethanol, a promising alternative energy source for the limited crude oil...
  4. pmc Genetic manipulation of lignin reduces recalcitrance and improves ethanol production from switchgrass
    Chunxiang Fu
    Forage Improvement Division and Plant Biology Division, The Samuel Roberts Noble Foundation, Ardmore, OK 73401, USA
    Proc Natl Acad Sci U S A 108:3803-8. 2011
    ..Biomass conversion research has developed processes for production of ethanol and other biofuels, but they remain costly primarily because of the intrinsic recalcitrance of biomass...
  5. ncbi Challenges in engineering microbes for biofuels production
    Gregory Stephanopoulos
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:801-4. 2007
    ..There is justified optimism that the full potential of biofuel production from cellulosic biomass will be obtainable in the next 10 to 15 years...
  6. ncbi Features of promising technologies for pretreatment of lignocellulosic biomass
    Nathan Mosier
    Laboratory of Renewable Resources Engineering, Department of Agricultural and Biological Engineering, Purdue University, Potter Engineering Center, 500 Central Drive, West Lafayette, IN 47907 2022, USA
    Bioresour Technol 96:673-86. 2005
    ..This paper reviews process parameters and their fundamental modes of action for promising pretreatment methods...
  7. ncbi Biomass recalcitrance: engineering plants and enzymes for biofuels production
    Michael E Himmel
    Chemical and Biosciences Center, National Renewable Energy Laboratory, Golden, CO 80401, USA
    Science 315:804-7. 2007
    ..To achieve sustainable energy production, it will be necessary to overcome the chemical and structural properties that have evolved in biomass to prevent its disassembly...
  8. ncbi Molecular mechanisms of alcohol-mediated carcinogenesis
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, University of Heidelberg, Heidelberg, Germany
    Nat Rev Cancer 7:599-612. 2007
    ..are not completely understood, most recent research has focused on acetaldehyde, the first and most toxic ethanol metabolite, as a cancer-causing agent...
  9. ncbi Ethanol modulation of intestinal epithelial tight junction barrier
    T Y Ma
    Division of Gastroenterology, Department of Medicine, Department of Veterans Affairs Medical Center, Long Beach 90822, USA
    Am J Physiol 276:G965-74. 1999
    Previous studies have shown that high concentrations of ethanol (>/=40%) cause functional damage of the gastrointestinal epithelial barrier by direct cytotoxic effect on the epithelial cells...
  10. pmc Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans
    M Wallner
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:15218-23. 2003
    gamma-Aminobutyric acid type A receptors (GABARs) have long been implicated in mediating ethanol (EtOH) actions, but so far most of the reported recombinant GABAR combinations have shown EtOH responses only at fairly high concentrations (..
  11. pmc Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice
    Wen Xing Ding
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastroenterology 139:1740-52. 2010
    ..We investigated whether macroautophagy, an evolutionarily conserved cellular mechanism that is commonly activated in response to stress, could protect liver cells from ethanol toxicity.
  12. ncbi Inhibition of ethanol-producing yeast and bacteria by degradation products produced during pre-treatment of biomass
    H B Klinke
    Department of Plant Research, Risø National Laboratory, P O Box 49, 4000 Roskilde, Denmark
    Appl Microbiol Biotechnol 66:10-26. 2004
    ..overview of the different inhibitors formed by pre-treatment of lignocellulosic materials and their inhibition of ethanol production in yeast and bacteria is given...
  13. pmc Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells
    Paul G Thomes
    Liver Study Unit, Department of Veterans Affairs, VA Nebraska Western Iowa Health Care System NWIHCS, Omaha, NE, USA
    Autophagy 9:63-73. 2013
    Acute and chronic ethanol administration increase autophagic vacuole (i.e., autophagosome; AV) content in liver cells. This enhancement depends on ethanol oxidation...
  14. pmc High ethanol titers from cellulose by using metabolically engineered thermophilic, anaerobic microbes
    D Aaron Argyros
    Mascoma Corporation, 67 Etna Road, Suite 300, Lebanon, NH 03766, USA
    Appl Environ Microbiol 77:8288-94. 2011
    ..The Δldh Δpta mutant was evolved for 2,000 h, resulting in a stable strain with 40:1 ethanol selectivity and a 4.2-fold increase in ethanol yield over the wild-type strain...
  15. pmc Mutant alcohol dehydrogenase leads to improved ethanol tolerance in Clostridium thermocellum
    Steven D Brown
    Biosciences Division and BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Proc Natl Acad Sci U S A 108:13752-7. 2011
    ..anaerobic, gram-positive bacterium that is a candidate microorganism for converting cellulosic biomass into ethanol through consolidated bioprocessing...
  16. doi Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives
    Akinori Matsushika
    Biomass Technology Research Center, National Institute of Advanced Industrial Science and Technology, Kure, Hiroshima 737 0197, Japan
    Appl Microbiol Biotechnol 84:37-53. 2009
    ..The research on yeast conversion of xylose to ethanol has been intensively studied especially for genetically engineered Saccharomyces cerevisiae during the last 20 ..
  17. ncbi Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice
    Justin S Rhodes
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, Oregon 97239, USA
    Physiol Behav 84:53-63. 2005
    ..It is therefore necessary to develop partial models. One important feature is drinking to the point where blood ethanol concentration (BEC) reaches levels that have measurable affects on physiology and/or behavior (>1...
  18. ncbi In silico aided metabolic engineering of Saccharomyces cerevisiae for improved bioethanol production
    Christoffer Bro
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs, Lyngby, Denmark
    Metab Eng 8:102-11. 2006
    ..strategies for metabolic engineering of the redox metabolism that will lead to decreased glycerol and increased ethanol yields on glucose under anaerobic conditions...
  19. ncbi Alcohol and cancer
    Paolo Boffetta
    International Agency for Research on Cancer, Lyon, France
    Lancet Oncol 7:149-56. 2006
    ..Evidence suggests that the effect of alcohol is modulated by polymorphisms in genes encoding enzymes for ethanol metabolism (eg, alcohol dehydrogenases, aldehyde dehydrogenases, and cytochrome P450 2E1), folate metabolism, and ..
  20. pmc NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    Liya Qin
    Bowles Center for Alcohol Studies, School of Medicine, Chapel Hill, NC 27599, USA
    J Neuroinflammation 9:5. 2012
    ..Previously, we reported that 10 daily doses of ethanol treatment induced innate immune genes in brain...
  21. doi Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells
    Sharada D Vangipuram
    Children s Research Center of Michigan, The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, USA
    Alcohol Clin Exp Res 36:788-97. 2012
    Prenatal exposure of the fetus to ethanol (EtOH) can be teratogenic. We previously showed that EtOH alters the cell fate of human neural stem cells (NSC)...
  22. doi Improvement of xylose fermentation in respiratory-deficient xylose-fermenting Saccharomyces cerevisiae
    Bingyin Peng
    The State Key Laboratory of Microbial Technology, Shandong University, Jinan, 250100, China
    Metab Eng 14:9-18. 2012
    ..significantly increased the aerobic-specific growth rate on xylose and slightly improved conversion of xylose to ethanol under oxygen-limited conditions, the elimination of respiration by deleting cytochrome C oxidase subunit IV gene ..
  23. pmc Clostridium thermocellum ATCC27405 transcriptomic, metabolomic and proteomic profiles after ethanol stress
    Shihui Yang
    Biosciences Division, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, Tennessee 37831, USA
    BMC Genomics 13:336. 2012
    ..expresses enzymes for both cellulose hydrolysis and its fermentation to produce fuels such as lignocellulosic ethanol. However, C...
  24. pmc Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis
    Albert E Chudley
    Children s Hospital, Health Sciences Centre, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man
    CMAJ 172:S1-S21. 2005
    ..These are the first Canadian guidelines for the diagnosis of FAS and its related disabilities, developed by broad-based consultation among experts in diagnosis...
  25. pmc CYP2E1 and oxidative liver injury by alcohol
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 44:723-38. 2008
    b>Ethanol-induced oxidative stress seems to play a major role in mechanisms by which ethanol causes liver injury. Many pathways have been suggested to contribute to the ability of ethanol to induce a state of oxidative stress...
  26. pmc miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2
    Sanjay Yadav
    Developmental Toxicology Division, Indian Institute of Toxicology Research CSIR IITR, MG Marg 80, Lucknow 226001, India
    J Biol Chem 286:37347-57. 2011
    ..We explored the role of microRNAs (miRNAs) in ethanol-induced apoptosis of neuronal cells...
  27. doi Possible metabolic pathways of ethanol responsible for oxidative DNA damage in human peripheral lymphocytes
    Yu Yan
    Department of Pharmacology, Shenyang Pharmaceutical University, China
    Alcohol Clin Exp Res 35:1-9. 2011
    b>Ethanol abuse, especially binge drinking, can be toxic to human organs. However, there have been few studies on the genotoxicity induced by ethanol in human peripheral lymphocytes under binge drinking conditions...
  28. ncbi Engineering yeast transcription machinery for improved ethanol tolerance and production
    Hal Alper
    Department of Chemical Engineering, Massachusetts Institute of Technology, Room 56 469, Cambridge, MA 02139, USA
    Science 314:1565-8. 2006
    ..Here we show the application of gTME to Saccharomyces cerevisiae for improved glucose/ethanol tolerance, a key trait for many biofuels programs...
  29. pmc New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis
    Michael G Smith
    Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 21:601-14. 2007
    ..The DNA sequencing approach described in this study allows the rapid elucidation of the DNA sequence of any microbe and, when combined with genetic screens, can identify many novel genes important for microbial pathogenesis...
  30. pmc Preclinical studies of alcohol binge drinking
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University and VA Medical Center, Portland, Oregon 97239, USA
    Ann N Y Acad Sci 1216:24-40. 2011
    ....
  31. ncbi Antioxidant properties of natural compounds used in popular medicine for gastric ulcers
    M G Repetto
    Laboratorio de Estrés Oxidativo en Patologías Humanas, Catedra de Quimica General e Inorganica, Departamento de Química Analítica y Fisicoquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
    Braz J Med Biol Res 35:523-34. 2002
    ..In this review article, we shall consider the role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol.
  32. pmc Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease
    Shashi Bala
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 286:1436-44. 2011
    ..In conclusion, our novel data demonstrate that chronic alcohol consumption increases miR-155 in macrophages via NF-κB and the increased miR-155 contributes to alcohol-induced elevation in TNFα production via increased mRNA stability...
  33. ncbi Detoxification of sugarcane bagasse hydrolysate improves ethanol production by Candida shehatae NCIM 3501
    Anuj Kumar Chandel
    Lignocellulose Biotechnology Laboratory, Department of Microbiology, University of Delhi South Campus, Benito Juarez Marg, New Delhi 110 021, India
    Bioresour Technol 98:1947-50. 2007
    ..Fermentation of these hydrolysates with Candida shehatae NCIM 3501 showed maximum ethanol yield (0.48g/g) from ion exchange treated hydrolysate, followed by activated charcoal (0.42g/g), laccase (0...
  34. ncbi Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver
    María Francisca Molina
    Department of Pharmacology, Faculty of Pharmacy, UCM, Madrid, Spain
    Biol Pharm Bull 26:1398-402. 2003
    ..75 mg/kg body weight) treatment has a protective effect on the pro-oxidant-antioxidant state following chronic ethanol treatment in mice...
  35. pmc Environmental, economic, and energetic costs and benefits of biodiesel and ethanol biofuels
    Jason Hill
    Department of Ecology, Evolution, and Behavior, University of Minnesota, St Paul, MN 55108, USA
    Proc Natl Acad Sci U S A 103:11206-10. 2006
    ..We use these criteria to evaluate, through life-cycle accounting, ethanol from corn grain and biodiesel from soybeans...
  36. doi The ethanol stress response and ethanol tolerance of Saccharomyces cerevisiae
    D Stanley
    School of Engineering and Science, Victoria University, Melbourne, Vic, Australia
    J Appl Microbiol 109:13-24. 2010
    ..beverage and bioethanol production; however, its performance during fermentation is compromised by the impact of ethanol accumulation on cell vitality...
  37. doi Stress-related challenges in pentose fermentation to ethanol by the yeast Saccharomyces cerevisiae
    João R M Almeida
    Applied Microbiology, Lund University, Lund, Sweden EMBRAPA Agroenergy, PqEB, Brasilia, 70770 901 DF, Brazil
    Biotechnol J 6:286-99. 2011
    ..Fermentation of these pentose sugars to ethanol by engineered Saccharomyces cerevisiae under industrial process conditions is the subject of this review...
  38. doi The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells
    Jiayu Gao
    Medicines Research Group, School of Health and Bioscience, University of East London, Stratford, London E15 4LZ, UK
    Toxicol Appl Pharmacol 254:221-8. 2011
    ..These results provide further insight into the molecular mechanisms underlying the clinical use of this herb as an adjuvant to lung cancer therapy...
  39. pmc A Drosophila model for alcohol reward
    Karla R Kaun
    Department of Anatomy, University of California, San Francisco, California, USA
    Nat Neurosci 14:612-9. 2011
    ..We developed a new assay for investigating the motivational properties of ethanol in the genetically tractable model Drosophila melanogaster...
  40. pmc Cellulase, clostridia, and ethanol
    Arnold L Demain
    Charles A Dana Research Institute for Scientists Emeriti, HS 330, Drew University, Madison, NJ 07940, USA
    Microbiol Mol Biol Rev 69:124-54. 2005
    Biomass conversion to ethanol as a liquid fuel by the thermophilic and anaerobic clostridia offers a potential partial solution to the problem of the world's dependence on petroleum for energy...
  41. pmc Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents
    Laurent Ferrier
    Unité de Neuro Gastroentérologie et Nutrition, Institut National de la Recherche Agronomique, 180 chemin de Tournefeuille, B P 3, 31931 Toulouse Cedex 9, France
    Am J Pathol 168:1148-54. 2006
    ..Because endotoxins can cross damaged mucosa, we investigated the mechanisms through which ethanol impairs the colonic epithelium of rats submitted to acute alcohol intake...
  42. pmc Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1
    Ian King
    Department of Anatomy, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 31:1139-48. 2011
    In both mammalian and insect models of ethanol-induced behavior, low doses of ethanol stimulate locomotion. However, the mechanisms of the stimulant effects of ethanol on the CNS are mostly unknown...
  43. ncbi Tailoring wine yeast for the new millennium: novel approaches to the ancient art of winemaking
    I S Pretorius
    Institute for Wine Biotechnology, University of Stellenbosch, Stellenbosch, ZA 7600, South Africa
    Yeast 16:675-729. 2000
    ..The primary role of wine yeast is to catalyze the rapid, complete and efficient conversion of grape sugars to ethanol, carbon dioxide and other minor, but important, metabolites without the development of off-flavours...
  44. doi Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation
    Lin Lin Wang
    Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, PR China
    Hum Reprod 24:562-79. 2009
    ..microRNAs (miRNAs) play an important role in development and are associated with birth defects. Data are scant on the role of miRNAs in birth defects arising from exposure to environmental factors such as alcohol...
  45. ncbi Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon
    C W Hodge
    Department of Neurology and Ernest Gallo Clinic and Research Center, University of California, San Francisco 94110, USA edu
    Nat Neurosci 2:997-1002. 1999
    Several of the actions of ethanol are mediated by gamma-aminobutyrate type A (GABA(A)) receptors...
  46. pmc The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress
    Sandeep Kumar
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 205:529-64. 2009
    The past decade has brought many advances in our understanding of GABA(A) receptor-mediated ethanol action in the central nervous system...
  47. doi Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
    Silvia Alfonso-Loeches
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, 46012 Valencia, Spain
    J Neurosci 30:8285-95. 2010
    ..Alcohol abuse induces brain damage and can sometimes lead to neurodegeneration. We recently found that ethanol can promote TLR4 signaling in glial cells by triggering the induction of inflammatory mediators and causing cell ..
  48. doi How biotech can transform biofuels
    Lee R Lynd
    Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, New Hampshire 03755, USA
    Nat Biotechnol 26:169-72. 2008
    For cellulosic ethanol to become a reality, biotechnological solutions should focus on optimizing the conversion of biomass to sugars.
  49. ncbi Fuel ethanol production from lignocellulose: a challenge for metabolic engineering and process integration
    J Zaldivar
    Center for Process Biotechnology, Department of Biotechnology, Technical University of Denmark, Lyngby
    Appl Microbiol Biotechnol 56:17-34. 2001
    ..Bioethanol (ethanol from biomass) is an attractive, sustainable energy source to fuel transportation...
  50. ncbi Aldehyde dehydrogenase is essential for both adult and larval ethanol resistance in Drosophila melanogaster
    James D Fry
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Genet Res 87:87-92. 2006
    The enzyme aldehyde dehydrogenase (ALDH) is essential for ethanol metabolism in mammals, converting the highly toxic intermediate acetaldehyde to acetate...
  51. doi Activated microglia are implicated in cognitive deficits, neuronal death, and successful recovery following intermittent ethanol exposure
    Ya Nan Zhao
    Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, PR China
    Behav Brain Res 236:270-82. 2013
    ..Rats were given orally a priming dose of 5 g/kg ethanol and then 3g/kg every 8h for 4 days, followed by a 3-day ethanol-withdrawal period...
  52. pmc Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model
    Elhaseen Elamin
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 7:e35008. 2012
    ..Exposure to ethanol and its metabolite, acetaldehyde at relatively high concentrations have been shown to disrupt intestinal ..
  53. pmc Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent
    Robert J Lipinski
    The Bowles Center For Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43067. 2012
    Prenatal ethanol exposure is the leading preventable cause of congenital mental disability...
  54. ncbi Consolidated bioprocessing of cellulosic biomass: an update
    Lee R Lynd
    Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA
    Curr Opin Biotechnol 16:577-83. 2005
    ..Recent studies of the fundamental principles of microbial cellulose utilization support the feasibility of CBP...
  55. pmc Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
    Sanjoy Roychowdhury
    Departments of Pathobiology, Center for Liver Disease Research, Cleveland Clinic, Cleveland, OH, USA
    Hepatology 57:1773-83. 2013
    Hepatocyte cell death via apoptosis and necrosis are major hallmarks of ethanol-induced liver injury. However, inhibition of apoptosis is not sufficient to prevent ethanol-induced hepatocyte injury or inflammation...
  56. pmc Ethanol sensitizes mitochondria to the permeability transition by inhibiting deacetylation of cyclophilin-D mediated by sirtuin-3
    Nataly Shulga
    Department of Molecular Biology, School of Osteopathic Medicine, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    J Cell Sci 123:4117-27. 2010
    b>Ethanol increases the vulnerability of mitochondria to induction of the mitochondrial permeability transition (MPT). Cyclophilin-D activity enhances the potential for the permeability transition pore (PTP) to open...
  57. pmc Gpd1 and Gpd2 fine-tuning for sustainable reduction of glycerol formation in Saccharomyces cerevisiae
    Georg Hubmann
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31 bus 2438, B 3001 Heverlee, Flanders, Belgium
    Appl Environ Microbiol 77:5857-67. 2011
    ..The two isoenzymes play crucial roles in osmoregulation and redox balancing. Past approaches to increase ethanol yield at the cost of reduced glycerol yield have most often been based on deletion of either one or two isogenes (..
  58. pmc Epigenetic regulation in alcoholic liver disease
    Pranoti Mandrekar
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States
    World J Gastroenterol 17:2456-64. 2011
    ..Finally, the role of alcohol-mediated oxidative stress in epigenetic regulation in ALD is described. A better understanding of these mechanisms is crucial for designing novel epigenetic based therapies to ameliorate ALD...
  59. doi Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol
    Daiane L Gebauer
    Laboratório de Neuroquímica e Psicofarmacologia, Departamento de Biologia Celular e Molecular, Programa de Pós Graduação em Biologia Celular e Molecular, Faculdade de Biociencias, Pontificia Universidade Catolica do Rio Grande do Sul, Avenida Ipiranga, 6681, 90619 900 Porto Alegre, RS, Brazil
    Pharmacol Biochem Behav 99:480-6. 2011
    ..The benzodiazepines clonazepam, bromazepam, diazepam, and a moderate dose of ethanol significantly reduced shoal cohesion...
  60. ncbi Alcohol and cardiovascular health: the razor-sharp double-edged sword
    James H O'Keefe
    Mid America Heart Institute, University of Missouri, Kansas City, Missouri, USA
    J Am Coll Cardiol 50:1009-14. 2007
    ..The ethanol itself, rather than specific components of various alcoholic beverages, appears to be the major factor in ..
  61. doi Locomotor activity assay in zebrafish larvae: influence of age, strain and ethanol
    Celine de Esch
    TNO, Research Group Quality and Safety, Zeist, The Netherlands
    Neurotoxicol Teratol 34:425-33. 2012
    ..Locomotion was also measured in zebrafish larvae after exposure to different concentrations of ethanol (0; 0.5; 1; 2 and 4%) (AB and TL strain, 6 dpf; n=19/group)...
  62. doi Anxiogenic and stress-inducing effects of peripherally administered acetaldehyde in mice: similarities with the disulfiram-ethanol reaction
    Miguel A Escrig
    Area de Psicobiologia, Universitat Jaume I, Castello, Spain
    Pharmacol Biochem Behav 100:404-12. 2012
    Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called "flushing"...
  63. doi Hemicelluloses for fuel ethanol: A review
    F M Girio
    Laboratório Nacional de Energia e Geologia, I P, Unidade de Bioenergia, Estrada do Paco do Lumiar 22, 1649 038, Lisboa, Portugal
    Bioresour Technol 101:4775-800. 2010
    Hemicelluloses currently represent the largest polysaccharide fraction wasted in most cellulosic ethanol pilot and demonstration plants around the world...
  64. pmc Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
    Yunlong Liu
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Epigenetics 4:500-11. 2009
    ....
  65. pmc Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications
    Aaron R Wolen
    Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America
    PLoS ONE 7:e33575. 2012
    Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans...
  66. doi Perspectives and new directions for the production of bioethanol using consolidated bioprocessing of lignocellulose
    Qi Xu
    Chemical and Biosciences Center, National Renewable Energy Laboratory, Golden CO 80401, USA
    Curr Opin Biotechnol 20:364-71. 2009
    ..of microorganisms that can both convert biomass to fermentable sugars and ferment the resultant sugars to ethanol in a process known as consolidated bioprocessing (CBP)...
  67. ncbi Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway
    Hiroshi Kitagaki
    National Research Institute of Brewing, 3 7 1 Kagamiyama, Higashi Hiroshima City, Hiroshima 739 0046, Japan
    FEBS Lett 581:2935-42. 2007
    ..Here, we report the first evidence of the following processes, which are also characteristic of apoptosis, in ethanol-induced cell death in yeast: chromatin condensation and fragmentation, DNA cleavage, and a requirement for de ..
  68. pmc Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium
    Pratheesh Sathyan
    Department Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, Texas 77843 1114, USA
    J Neurosci 27:8546-57. 2007
    The fetal brain is sensitive to a variety of teratogens, including ethanol. We showed previously that ethanol induced mitosis and stem cell maturation, but not death, in fetal cerebral cortex-derived progenitors...
  69. doi Plant cell walls to ethanol
    Douglas B Jordan
    USDA Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, IL 61604, U S A
    Biochem J 442:241-52. 2012
    Conversion of plant cell walls to ethanol constitutes second generation bioethanol production...
  70. pmc Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence
    Nimish Sidhpura
    The Scripps Research Institute, Molecular and Integrative Neurosciences Department, La Jolla, California 92037, USA
    Biol Psychiatry 67:804-11. 2010
    Growing evidence supports a role of metabotropic glutamate receptors (mGluRs) in ethanol reinforcement, ethanol seeking, and ethanol withdrawal...
  71. pmc Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats
    Ali Keshavarzian
    Department of Internal Medicine, Division of Digestive Disease and Nutrition, Rush University Medical Center, Chicago, IL 60612, USA
    J Hepatol 50:538-47. 2009
    Not all alcoholics develop liver disease (ALD). Thus, excessive ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis (ASH) and ALD...
  72. ncbi Trends in biotechnological production of fuel ethanol from different feedstocks
    Oscar J Sánchez
    Department of Chemical Engineering, National University of Colombia at Manizales, Cra 27 No 64 60 Of F 505, Manizales, Caldas, Colombia
    Bioresour Technol 99:5270-95. 2008
    Present work deals with the biotechnological production of fuel ethanol from different raw materials...
  73. pmc Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3
    Sung Hwan Ki
    Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism NIAAA, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Hepatology 52:1291-300. 2010
    ..Here, we tested the effect of IL-22 on alcohol-induced liver injury in a murine model of chronic-binge ethanol feeding...
  74. pmc Intermittent access to 20% ethanol induces high ethanol consumption in Long-Evans and Wistar rats
    Jeffrey A Simms
    Ernest Gallo Clinic and Research Center, University of California San Francisco, Emeryville, California 94608, USA
    Alcohol Clin Exp Res 32:1816-23. 2008
    There has been some difficulty getting standard laboratory rats to voluntarily consume large amounts of ethanol without the use of initiation procedures...
  75. pmc Net energy of cellulosic ethanol from switchgrass
    M R Schmer
    U S Department of Agriculture Agricultural Research Service, University of Nebraska, 314 Biochemistry Hall, P O Box 830737, Lincoln, NE 68583 0737, USA
    Proc Natl Acad Sci U S A 105:464-9. 2008
    ..In this report, we summarize the agricultural energy input costs, biomass yield, estimated ethanol output, greenhouse gas emissions, and net energy results. Annual biomass yields of established fields averaged 5...
  76. doi Role of oxidative stress in alcohol-induced liver injury
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Toxicol 83:519-48. 2009
    ..Acute and chronic ethanol treatments increase the production of ROS, lower cellular antioxidant levels, and enhance oxidative stress in ..
  77. doi Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers
    María Isabel Queipo-Ortuño
    Laboratorio de Investigaciones Biomédicas del Hospital Virgen de la Victoria, Malaga, Spain
    Am J Clin Nutr 95:1323-34. 2012
    ..Few studies have investigated the effect of dietary polyphenols on the complex human gut microbiota, and they focused mainly on single polyphenol molecules and select bacterial populations...
  78. pmc Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites
    David N Criddle
    Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Proc Natl Acad Sci U S A 101:10738-43. 2004
    b>Ethanol causes pancreatic damage by an unknown mechanism. Previously, we demonstrated that a sustained rise of the cytosolic Ca(2+) concentration ([Ca(2+)](i)) causes pancreatic acinar cell injury...
  79. pmc Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae
    Dawid Brat
    Institute of Molecular Biosciences, Goethe Universitat Frankfurt, Max von Laue Str 9, D 60438 Frankfurt am Main, Germany
    Appl Environ Microbiol 75:2304-11. 2009
    In industrial fermentation processes, the yeast Saccharomyces cerevisiae is commonly used for ethanol production. However, it lacks the ability to ferment pentose sugars like d-xylose and l-arabinose...
  80. doi Critical role of TLR4 response in the activation of microglia induced by ethanol
    Sara Fernandez-Lizarbe
    Department of Cellular Pathology, Centro de Investigacion Principe Felipe, Valencia 46012, Spain
    J Immunol 183:4733-44. 2009
    ..We previously suggested that ethanol promotes inflammatory processes in the brain, up-regulating inflammatory mediators and signaling pathways ..
  81. pmc Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield
    A Joe Shaw
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 105:13769-74. 2008
    ..saccharolyticum, a thermophilic anaerobic bacterium that ferments xylan and biomass-derived sugars, to produce ethanol at high yield...
  82. doi Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    ..In this study, we investigated whether CYP2E1 plays a role in experimental alcoholic fatty liver in an oral ethanol-feeding model...
  83. ncbi Production of ethanol from corn stover hemicellulose hydrolyzate using Pichia stipitis
    Frank K Agbogbo
    Novozymes North America Inc, 77 Perry Chapel Church Road, P O Box 576, Franklinton, NC 27525, USA
    J Ind Microbiol Biotechnol 34:723-7. 2007
    Hemicellulose liquid hydrolyzate from dilute acid pretreated corn stover was fermented to ethanol using Pichia stipitis CBS 6054...
  84. ncbi Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise
    James Haorah
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Alcohol Clin Exp Res 29:999-1009. 2005
    ..BBB dysfunction is associated with disruption of tight junctions (TJ) in the brain endothelium. We propose that alcohol abuse may impair BBB permeability through TJ modification...
  85. pmc Ethanol elevates physiological all-trans-retinoic acid levels in select loci through altering retinoid metabolism in multiple loci: a potential mechanism of ethanol toxicity
    MAUREEN A KANE
    119 Morgan Hall, MC 3104, University of California, Berkeley, Berkeley, CA 94720 3104, USA
    FASEB J 24:823-32. 2010
    ..alcoholism, inhibition of retinol (vitamin A) activation into atRA has been credited widely as a mechanism of ethanol toxicity...
  86. pmc MicroRNAs: master regulators of ethanol abuse and toxicity?
    Rajesh C Miranda
    Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Ctr, College Station, Texas 77843 1114, USA
    Alcohol Clin Exp Res 34:575-87. 2010
    b>Ethanol exerts complex effects on human physiology and health...
  87. ncbi Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs
    Farah Esfandiari
    Department of Internal Medicine, University of California Davis, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 289:G54-63. 2005
    Previously, we showed that feeding micropigs ethanol with a folate-deficient diet promoted the development of hepatic injury while increasing hepatic levels of homocysteine and S-adenosylhomocysteine (SAH) and reducing the level of S-..
  88. pmc Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration
    Kathleen A Grant
    Integrative Neuroscience Initiative on Alcoholism, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Alcohol Clin Exp Res 32:1824-38. 2008
    ..of alcohol self-administration that initially employs schedule-induced polydipsia (SIP) to establish reliable ethanol consumption under open access (22 h/d) conditions with food and water concurrently available...
  89. pmc Identification of the [FeFe]-hydrogenase responsible for hydrogen generation in Thermoanaerobacterium saccharolyticum and demonstration of increased ethanol yield via hydrogenase knockout
    A Joe Shaw
    Dartmouth College, Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755, USA
    J Bacteriol 191:6457-64. 2009
    ..A strain with hfs and ldh deletions exhibited an increased ethanol yield from consumed carbohydrates and represents a new strategy for engineering increased ethanol yields in T...
  90. ncbi A new naturally occurring GABA(A) receptor subunit partnership with high sensitivity to ethanol
    Joseph Glykys
    Interdepartmental PhD Program for Neuroscience and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
    Nat Neurosci 10:40-8. 2007
    ..These GABA(A)Rs are a preferred target of low, sobriety-impairing concentrations of ethanol. Here we demonstrate a new naturally occurring GABA(A)R subunit partnership: delta subunits of hippocampal ..
  91. ncbi The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol
    Cecilia M Borghese
    The University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, 1 University Station A4800, Austin, TX 78712 0159, USA
    J Pharmacol Exp Ther 316:1360-8. 2006
    ..delta-containing GABA(A)Rs expressed in Xenopus oocytes were found to be sensitive to low concentrations of ethanol (1-3 mM)...
  92. pmc Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Dialogues Clin Neurosci 8:463-77. 2006
    ..This regulation of the HPA axis maintains healthy brain function and protects against neuropsychiatric disease. Ethanol sensitivity is influenced by elevations in neuroactive steroids that enhance the GABAergic effects of ethanol, ..
  93. ncbi Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous
    Esa R Korpi
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, FI 00014 University of Helsinki, Helsinki, Finland
    Alcohol 41:163-76. 2007
    ..alpha6 and delta subunits, expressed in the cerebellar and cochlear nucleus granule cells, have been linked to ethanol sensitivity and voluntary ethanol drinking. Here, we review the findings...
  94. ncbi Effects of ethanol and water extracts of propolis (bee glue) on acute inflammatory animal models
    Fuliang Hu
    College of Animal Science, Zhejiang University, Hangzhou 310029, China
    J Ethnopharmacol 100:276-83. 2005
    The anti-inflammatory effects of ethanol (EEP) and water (WSD) extracts in ICR mice and Wistar rats were analyzed...
  95. ncbi Exercise reverses ethanol inhibition of neural stem cell proliferation
    Fulton T Crews
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 1021 Thurston Bowles Building, CB 7178, Chapel Hill, NC 27599 7178, USA
    Alcohol 33:63-71. 2004
    ..neural stem cell proliferation in the hippocampus and improve performance on learning tests, whereas acute ethanol consumption decreases neural stem cell proliferation in the hippocampus...
  96. ncbi Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus
    Enrico Sanna
    Department of Experimental Biology, Section of Neuroscience, University of Cagliari, 09123 Cagliari, Italy
    J Neurosci 24:6521-30. 2004
    ..been recognized as one of the main neurochemical mechanisms underlying many of the pharmacological actions of ethanol. However, more recent data have suggested that certain behavioral and electrophysiological actions of ethanol are ..
  97. doi Fructose: metabolic, hedonic, and societal parallels with ethanol
    Robert H Lustig
    Division of Endocrinology, University of California, San Francisco, CA 94143 0434, USA
    J Am Diet Assoc 110:1307-21. 2010
    ..to examine the metabolic, hedonic, and societal similarities between fructose and its fermentation byproduct ethanol. Elucidation of fructose metabolism in liver and fructose action in brain demonstrate three parallelisms with ..
  98. pmc The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    Howard J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Alcohol Res Health 30:5-13. 2007
    ..e., ethanol) to acetaldehyde; these alleles have a protective effect on the risk of alcoholism...
  99. doi Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae
    Katsunori Yoshikawa
    Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, Osaka, Japan
    FEMS Yeast Res 9:32-44. 2009
    We quantified the growth behavior of all available single gene deletion strains of budding yeast under ethanol stress...
  100. ncbi Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection
    Riccardo A Lencioni
    Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma 67, I 56125 Pisa, Italy
    Radiology 228:235-40. 2003
    To compare the effectiveness of radio-frequency (RF) thermal ablation with that of percutaneous ethanol injection (PEI) for the treatment of small hepatocellular carcinoma (HCC) in patients with cirrhosis.
  101. ncbi Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening
    Brent Lockwood
    Department of Biopharmaceutical Sciences, Programs in Human Genetics and Biological Sciences, Wheeler Center for the Neurobiology of Addiction, University of California, San Francisco, CA 94143 0446, USA
    Pharmacol Biochem Behav 77:647-54. 2004
    ..Our analyses showed that like adults, the larval zebrafish exhibited a dose-dependent locomotor response to ethanol: intermediate doses led to hyperactivity, whereas high doses have a neurodepressive effect resulting in ..

Research Grants76

  1. Detection of Ethanol in Human Breath: Mini-GC Use and Exhaled Breath Condensate
    Richard Melker; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Ethanol is one of the most widely consumed drugs with resultant profound consequences to individuals and society...
  2. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  3. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..aged men, and it is unclear whether the effects of aging and estrogen (E2) deficiency are additive with regard to ethanol-induced cardiac ischemia/reperfusion (I/R) injury...
  4. Effect of PPARy Ligands on Alcohol-Induced Alveolar Macrophage Oxidative Stress
    Samantha M Yeligar; Fiscal Year: 2013
    ..These hypotheses will be investigated by using a mouse model of chronic alcohol consumption, an in vitro ethanol exposed mouse AM cell line, MH-S, and AMs isolated from human subjects...
  5. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..alcohol accelerates retinoid oxidation, involving ethanol-inducible cytochromes like Cyp2E1;and 3...
  6. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..have shown that serum and glucocorticoid- regulated kinase 1, Sgk1, is prominently up regulated by acute ethanol (2 g/kg) in the prefrontal cortex (PFC) of DBA/2J mice...
  7. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ..anxiolytic effects in both human and animal models and that rapid tolerance to the anxiolytic responses of acute ethanol also develops...
  8. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..and animal studies indicate that the stable downregulation of genes protective against the reinforcing effects of ethanol, such as brain derived neurotrophic factor (BDNF), may result in increased alcohol consumption...
  9. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    ..Our central hypothesis is that ethanol-induced modifications of mitochondrial structure and function play a key role in the regulation of hepcidin ..
  10. Functional characters of non-coding RNAs in alcoholic liver injury
    Fanyin Meng; Fiscal Year: 2013
    ..Several recent studies have provided compelling evidence showing that ethanol-sensitive miRNAs are indeed regulatory master-switches...
  11. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ..However, metabolic basis of alcoholic pancreatitis is relatively obscure. Role of ethanol metabolites, acetaldehyde (oxidative metabolite) and fatty acid ethyl esters (FAEEs, nonoxidative lipid ..
  12. Alcohol-Induced Bone Resorption: The Role of Oxidative Stress
    Martin J J Ronis; Fiscal Year: 2013
    ..provided by applicant): Although it is well known that women are more susceptible to the toxic effects of ethanol (EtOH) than men, much less is known about the molecular mechanisms underlying alcohol toxicity in women ..
  13. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..The specific objectives of this proposal are to: 1) Determine the effects of proteasome inhibition and ethanol on sensitization to TNF hepatotoxicity, 2) Determine the role of lysosomal membrane permeability and cathepsins B ..
  14. Role of ALDH7A1 in Ethanol-Induced Oxidative Damage
    CHAD NICHOLAS BROCKER; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): A comprehensive understanding of the fundamental mechanisms driving ethanol toxicity augments the development of highly effective, targeted therapies to both prevent and treat health problems caused ..
  15. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): This proposal will address a novel aspect of ethanol's developmental neurotoxicity, i.e. its effect on cholesterol homeostasis in the central nervous system...
  16. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..This is a major health concern as the aging population continues to escalate. In aging rats, chronic ethanol consumption results in regression of Purkinje neuron (PN) dendrites, a process that surely alters cerebellar ..
  17. Exploratory Studies on the Anti-Breast Cancer Function of Bamboo Extract
    Jun Panee; Fiscal Year: 2010
    ..carried out in the laboratory of the principal investigator focused on the anti-breast cancer function of an ethanol/water extract from bamboo Phyllostachys edulis, one of the most widely distributed and fastest growing plants in ..
  18. Mechanisms of Neutrophil-induced Liver Toxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2012
    ..of metallothioneins and to study their pathophysiological role during hepatic IRP injury in lean livers and ethanol-induced steatotic livers as well as their potential to use MT gene expression as therapeutic target...
  19. Histone Methylation: a role in excessive ethanol intake and self-administration
    Jennifer A Rinker; Fiscal Year: 2012
    ..Histone acetylation has been implicated in the regulation of acute responses to ethanol, development of tolerance, and withdrawal...
  20. MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISM
    Radhakrishna Rao; Fiscal Year: 2013
    ..Our studies conducted so far have shown that acetaldehyde, the metabolic product of ethanol, disrupts the intestinal epithelial barrier function and increases the permeability to endotoxins...
  21. GENETIC REGULATION OF ALCOHOL METABOLISM IN YEAST
    Elton T Young; Fiscal Year: 2013
    ..respiratory metabolism is induced that allows them to utilize a variety of secondary carbon sources, ranging from ethanol and glycerol to complex stored carbohydrates and lipids...
  22. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..in a macrophage cell line chronically cultured in alcohol, and in Kupffer cells from mice chronically fed ethanol intragastrically...
  23. Genetic Vulnerability to Alcohol Withdrawal and Genetically Correlated Behaviors
    Kari J Buck; Fiscal Year: 2012
    ..1 Mb QTL interval on a uniform background, we propose: (1) Test genetically correlated responses to ethanol and other sedative-hypnotics...
  24. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..The goal of Experiment 1 is to determine if the taste of choline will deter the rat from consuming as much ethanol as the ethanol-only group. If so, subcutaneous injections of choline and vehicle will be necessary...
  25. HEPATIC DEGRADATION OF CYTOCHROME P450 ENZYMES
    Maria Almira Correia; Fiscal Year: 2013
    ..e. ethanol (EtOH), as well as enhanced drug-mediated P450 degradation (i.e. grapefruit juice furanocoumarins)...
  26. Role of sumoylation in alcoholic liver disease
    Maria Lauda Tomasi; Fiscal Year: 2013
    ..that ubiquitin conjugating enzyme 9 (Ubc9), the sole E2 enzyme of sumoylation, is induced in intragastric ethanol- infusion (EI) treated mice but the functional significance of this is unknown...
  27. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..Preliminary studies show that EAAT3- mediated cysteine uptake is also sensitive to opiates and ethanol, as well as nicotine and cannabinoids, suggesting that it may serve as a nexus for the epigenetic effects of ..
  28. Role of Mitochondria Targeted CYP2E1 and HO-1 in Alcohol Mediated Tissue Injury
    Narayan G Avadhani; Fiscal Year: 2012
    ..b>Ethanol mediated ROS production and mt-dysfunction will be studied in stable cell lines expressing predominantly mt- or ..
  29. Chronic ethanol, B cell competence and lymphoid integrity
    Thomas J Waldschmidt; Fiscal Year: 2010
    ..In addition to immune deficiency caused by extended ethanol intake, children with fetal alcohol syndrome (FAS) also display immunologic deficits and higher infection rates...
  30. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..Importantly, ethanol has been shown to lower the activation threshold of TRPV1 and we propose that ethanol may contribute to ..
  31. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..How ethanol exposure during early life produces a neurotoxic action on beta-endorphin neurons is not completely well ..
  32. MECHANISMS OF LIVER INJURY BY HEPATITIS C AND ALCOHOL
    Steven A Weinman; Fiscal Year: 2013
    ..are: (1) to develop a novel nanoscale isoelectic focusing method to determine the nature and mechanism of HCV/ethanol-induced posttranslational modifications of FOXO3;(2) to determine why there is abnormal cytosolic accumulation of ..
  33. GSK3beta, a mediator of ethanol neurotoxicity
    Xianglin Shi; Fiscal Year: 2013
    ..The depletion of neurons in the developing CNS is the most deteriorating effect of ethanol. The loss of CNS neurons may underlie many of the behavioral deficits observed in FASD...
  34. The Effects of Ethanol on Microtubules during Mouse Pre-implantation Development
    Yixian Zheng; Fiscal Year: 2012
    ..Numerous studies have been published characterizing the effect of ethanol on a developing fetus. However, the specific mechanisms have been proven more difficult to establish...
  35. Molecular Analysis of Alcohol Effects on Human Oral Epithelium Cells'Epigenome
    Alison Urvalek; Fiscal Year: 2013
    ..Genome-wide sequencing of ethanol treated immortalized OKF6-TERT1 human oral epithelial cells will be performed with the assistance of our ..
  36. Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soy
    Martin J J Ronis; Fiscal Year: 2013
    ..The major role of ethanol (EtOH) appears to be to act as a tumor promoter, increasing the rate of development of tumors initiated as a ..
  37. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    ..We have identified a homogeneous population of GABA neurons in the VTA that are excited by low-dose ethanol, but inhibited by moderate to high-dose ethanol, become tolerant to chronic ethanol, evince hyperexcitabililty ..
  38. Epigenetic Effects of Prenatal Ethanol Exposure
    Thomas P Yang; Fiscal Year: 2010
    ..However, the mechanisms by which ethanol causes the developmental anomalies and neurotoxicity characteristic of FAS are poorly understood...
  39. Role of AIE in Epigenetic and Behavioral Changes at Adulthood
    Subhash C Pandey; Fiscal Year: 2013
    ..b>Ethanol produces anxiolytic effects in both animals and humans and adolescents are less sensitive to the sedative and ..
  40. Mechanisms of ER stress - induced fatty liver
    D Thomas Rutkowski; Fiscal Year: 2013
    ..Atf6[unreadable]-null mice to test whether impairment of ER function sensitizes mice to steatosis during chronic ethanol consumption...
  41. MIF in progression and treatment of ALD
    Laura E Nagy; Fiscal Year: 2013
    ..Enhanced inflammation in the liver during ethanol exposure is an important contributor to ALD...
  42. Role of Mitochondrial Aldehyde Dehydrogenases in Ethanol Metabolism and Toxicity
    Vasilis Vasiliou; Fiscal Year: 2010
    ..Some of these pathological effects can be attributed to ethanol metabolism...
  43. Diet and Alcohol Induced Epigenetic Changes in Oral Cavity Carcinogenesis Model
    Lorraine J Gudas; Fiscal Year: 2013
    ..We will use this 4-nitroquinoline oxide (4-NQO) carcinogenesis model to measure the effects of alcohol (ethanol) on the incidence of oral cavity carcinogenesis and on epigenetic changes...
  44. ALCOHOL AND HYPERPROLACTINEMIA
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..Thus, the proposed studies will provide an important clue about prenatal ethanol-induced epigenetic modifications in D2R, creating a cellular substrate vulnerable to reproductive dysfunction and ..
  45. Probiotics and HIF signaling in Alcoholic Liver Disease
    Wenke Feng; Fiscal Year: 2013
    ..To test this hypothesis, we will carry our following specific aims: Specific Aim 1. Determine the effects of ethanol and probiotics on intestinal HIF signaling and mechanisms in ALD. Specific Aim 2...
  46. Regulated Hypothermia to Treat Hypoxic-Ischemic Brain Injury
    Laurence M Katz; Fiscal Year: 2010
    ..b>Ethanol and neurotensin both induce regulated hypothermia in animals and humans...
  47. The Role of CYP1B1 in the Recurrence of Head and Neck Cancer
    Ekaterina G Shatalova; Fiscal Year: 2013
    ..The tobacco smoke carcinogen benzo(a)pyrene (B(a)P), ethanol from alcoholic drinks and the female hormone estrogen are all metabolized by cytochrome P450 (CYP) 1B1 to ..
  48. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher L Cunningham; Fiscal Year: 2012
    ..by applicant): This project is directly concerned with the learning and motivational processes that mediate ethanol-seeking behavior...
  49. Ethanol Regulates Vacuolar ATPase &PEDF
    Chuhan Chung; Fiscal Year: 2013
    ..Moreover, stimuli such as ethanol and others increase v-ATPase translocation to plasma membranes...
  50. Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
    Lopa Mishra; Fiscal Year: 2013
    ..mutant mice result in a progeny that show (a) enhanced susceptibility to spontaneous tumor development as well as ethanol teratogenicity (b) whether the hepatocytes and MEFs derived from such crosses undergo progressive DNA damage...
  51. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..and concentration- dependent self-exposure to, various psychoactive drugs including cocaine, methamphetamine, ethanol and caffeine...
  52. Cell Death in Alcoholic Heart and Muscle
    Emanuel Rubin; Fiscal Year: 2013
    ..Studies in human alcoholics and animal models have demonstrated that chronic ethanol consumption increases oxidative stress and other cellular stress factors and enhances the susceptibility to ..
  53. Alcohol and Breast Cancer
    Jia Luo; Fiscal Year: 2012
    ..Our central hypothesis is that ethanol-induced oxidative stress up- regulates MUC1 as an adaptor protein to promote ErbB2/ ?-catenin interaction which ..
  54. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    ..Although abused inhalants produce ethanol-like signs of intoxication, their sites and mechanisms of action that underlie these effects are largely unknown...
  55. Adolescent Alcohol,Dysregulated Stress System, and PTSD Vulnerability
    GERHARD H SCHULTEIS; Fiscal Year: 2013
    ..Specific Aim 2 will probe for any lasting consequences into young adulthood of varying history of intermittent ethanol vapor exposure (10 hr exposure per day on 1, 3 or 5 days/week, target blood alcohol levels of 200-300 mg/dL) ..
  56. HCV in Alcoholics
    Jack R Wands; Fiscal Year: 2011
    ..of CV infection, the reasons for these high rates are unknown but may partially relate to the effects of ethanol on the humoral and cellular immune responses to viral structural and non-structural proteins...
  57. Inhibition of Carboxylesterase Metabolism by Ethanol
    Robert B Parker; Fiscal Year: 2011
    ..Recent evidence from an animal model suggests that ethanol is a potent inhibitor of carboxylesterase- mediated first-pass drug metabolism, but important questions remain ..
  58. ROLE OF WNT SIGNALING IN CHRONIC ALCOHOLIC LIVER DISEASE
    Miran Kim; Fiscal Year: 2013
    ..While the toxic effects of ethanol and ts metabolites promote liver injury and cell death, the long-term adverse effects of ethanol on ..
  59. MECHANISM OF ACTION OF A MAJOR FOLATE ENZYME
    Sergey A Krupenko; Fiscal Year: 2013
    ..Accordingly, our third hypothesis is that active metabolites of acetaminophen and ethanol inhibit FDH activity by forming adducts with its prosthetic group and this inhibition contributes to liver injury...
  60. Effects of Ethanol on Proteasome-HCV Core Protein Interactions
    NATALIA ALEKSANDR OSNA; Fiscal Year: 2010
    ..proteins, known as core protein, induces oxidative stress in liver cells, and this is further potentiated by ethanol. Oxidative stress modulates the functions of many enzymes, including the multi-catalytic protein-degrading enzyme,..
  61. Genetic Determinants of Drug Effects
    Tamara J Phillips; Fiscal Year: 2012
    ..work will build on our previous genetic and pharmacological investigations and will additionally explore nicotine/ethanol interactions by examining patterns of gene expression that are specific for each drug, as well as those that are ..
  62. Epigenetic regulation of alcoholic steatohepatitis in a mouse model
    CHARLES HOPKINSON HALSTED; Fiscal Year: 2012
    ..of regulatory genes that result from the induction of aberrant hepatic methionine metabolism by exposure to ethanol. The study will use the cystathionine beta synthase (CbS) deficient mouse model of aberrant methionine metabolism ..
  63. RAX, PKR and ethanol neurotoxicity
    Gang Chen; Fiscal Year: 2013
    ..FASD-related costs are more than $6 billion annually. Identification of the mechanism of ethanol toxicity in the brain and determination of the effective therapeutic target(s) are cited as importat goals in the ..
  64. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ..Recent data in rats show that ethanol-induced behavioral deficits can be ameliorated by transplantation of fetal, choline-rich tissue...
  65. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    The long term objectives of this research are to understand the molecular basis of ethanol-induced hypothyroidism, and to ultimately utilize this understanding to clarify the effects of ethanol on thermoregulatory function...
  66. Prenatal ethanol exposure effects on reward circuitry and ethanol consumption
    JAMES PATRICK RICE; Fiscal Year: 2012
    ..The applicant will acquire novel approaches and skills to address alcohol-related effects in fetal ethanol exposed rats, adding specific behavioral and neurobiological techniques to a broad foundation of skills in ..
  67. EFFECTS OF ETHANOL ON PHOSPHOLIPASE D MEDIATED SIGNALING
    Joel Horwitz; Fiscal Year: 2003
    Chronic ethanol consumption has profound effects on signal transduction...
  68. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    ..Several hypotheses regarding the mechanisms by which alcohol induces liver injury have been postulated, including ethanol metabolism-generated oxidative stress, endotoxemia, and proinflammatory cytokine production...
  69. ALCOHOL AND CELL ADHESION
    MICHAEL EDWARD CHARNESS; Fiscal Year: 2010
    b>Ethanol inhibits cell adhesion mediated by the L1 cell adhesion molecule in neural cells and in fibroblasts ransfected with human L1...
  70. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2002
    b>Ethanol has reinforcing properties in man that are thought to contribute to alcohol abuse and alcoholism. In rats ethanol is readily self-administered orally when taste factors are minimized by preexposing the rats to sweetened solutions...
  71. Chronic Ethanol Effects on CNS Opiate Receptors
    Linda Saland; Fiscal Year: 2003
    Chronic ethanol consumption and its continued reinforcement is an ongoing major health and societal problem...
  72. ETHANOL AND NMDA RECEPTOR FUNCTION
    RUEBEN GONZALES; Fiscal Year: 1999
    ..An area of emerging importance in understanding the neurochemical mechanisms which mediate or are consequent to ethanol use and abuse is that of excitatory amino acid (EAA) function...
  73. Role of Adipose in Ethanol-Induced Tissue Injury
    Laura Nagy; Fiscal Year: 2009
    ..Chronic, heavy ethanol exposure results in the development of glucose intolerance and hepatic insulin resistance...
  74. Model to study the effects of ethanol on erythropoiesis
    Stephen Koury; Fiscal Year: 2001
    DESCRIPTION (Scanned from the applicant's description): Chronic ingestion of ethanol has been proposed to hasten the development and increase the severity of megaloblastic anemia in human patients, as well as cause anemia in patients ..
  75. ETHANOL MEDIATED OSTEOPOROSIS AND INTERLEUKIN 6
    Evan Keller; Fiscal Year: 2002
    DESCRIPTION (Adapted from the Investigator's Abstract): It is well established that chronic ethanol exposure can induce osteoporosis, a debilitating and costly disease...
  76. Real-time measurement of ethanol's effect on cyclic AMP metabolism in live cells
    Masami Yoshimura; Fiscal Year: 2009
    ..long-term goal of this research is to elucidate the molecular and cellular mechanisms underlying the effects of ethanol on the cyclic adenosine monophosphate (cAMP) signaling pathway in the central nervous system...