Genomes and Genes
Summary: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Publications394 found, 100 shown here
- The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processesCraig W Berridge
Departments of Psychology and Psychiatry, University of Wisconsin, Madison, WI 53706, USA
Brain Res Brain Res Rev 42:33-84. 2003Through a widespread efferent projection system, the locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system...
- An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Annu Rev Neurosci 28:403-50. 2005Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of behavior than investigators previously ..
- The locus coeruleus and noradrenergic modulation of cognitionSusan J Sara
CNRS UMR 7152, College de France, Paris 75005, France
Nat Rev Neurosci 10:211-23. 2009....
- Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorderFrank P Bymaster
Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
Neuropsychopharmacology 27:699-711. 2002The selective norepinephrine (NE) transporter inhibitor atomoxetine (formerly called tomoxetine or LY139603) has been shown to alleviate symptoms in Attention Deficit/Hyperactivity Disorder (ADHD)...
- Generation of the melatonin endocrine message in mammals: a review of the complex regulation of melatonin synthesis by norepinephrine, peptides, and other pineal transmittersValerie Simonneaux
Laboratoire de Neurobiologie Rythmes, UMR 7518 CNRS ULP, 12, rue de l université, 67000 Strasbourg, France
Pharmacol Rev 55:325-95. 2003..circadian clock, situated in the suprachiasmatic nucleus of the hypothalamus, which controls the release of norepinephrine from the dense pineal sympathetic afferents...
- Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotoninR B Rothman
Clinical Psychopharmacology Section, Intramural Research Program, NIDA, NIH, Baltimore, Maryland 21224, USA
Synapse 39:32-41. 2001..Both amphetamine and cocaine increase norepinephrine (NE) via stimulation of release and inhibition of reuptake, respectively...
- Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevationKazuko Masuo
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita City, Osaka 565 0871, Japan
Hypertension 42:474-80. 2003..To clarify the relations between serum uric acid, plasma norepinephrine, and insulin or leptin levels in subjects with weight gain-induced blood pressure elevation, we conducted the ..
- Adrenergic pharmacology and cognition: focus on the prefrontal cortexBrian P Ramos
Department Neurobiology, Yale Medical School, New Haven, CT 06520 8001, USA
Pharmacol Ther 113:523-36. 2007b>Norepinephrine (NE) has widespread projections throughout the brain, and thus, is ideally positioned to orchestrate neural functions based on arousal state...
- Targeting QseC signaling and virulence for antibiotic developmentDavid A Rasko
Department of Microbiology, University of Texas UT Southwestern Medical Center, Dallas, TX 75390, USA
Science 321:1078-80. 2008..Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs...
- Noradrenergic pain modulationAntti Pertovaara
Biomedicum Helsinki, Institute of Biomedicine Physiology, PO Box 63, University of Helsinki, FIN 00014 Helsinki, Finland
Prog Neurobiol 80:53-83. 2006b>Norepinephrine is involved in intrinsic control of pain. Main sources of norepinephrine are sympathetic nerves peripherally and noradrenergic brainstem nuclei A1-A7 centrally...
- Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brainPaolo Follesa
Department of Experimental Biology, Section of Neuroscience, University of Cagliari, Cagliari, Italy
Brain Res 1179:28-34. 2007..neurotrophic factor, fibroblast growth factor, and nerve growth factor as well as the concentration of norepinephrine in the rat brain...
- Norepinephrine directly activates adult hippocampal precursors via beta3-adrenergic receptorsDhanisha J Jhaveri
The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland 4072, Australia
J Neurosci 30:2795-806. 2010..Among the neurotransmitters that are widely implicated in regulating this process are serotonin and norepinephrine, levels of which are modulated by stress, depression and clinical antidepressants...
- Increased extracellular concentrations of norepinephrine in cortex and hippocampus following vagus nerve stimulation in the ratRodney W Roosevelt
Brain and Cognitive Sciences Program, Department of Psychology, Southern Illinois University, IL 62901 6512, USA
Brain Res 1119:124-32. 2006..information about visceral states and it provides input to the locus coeruleus (LC), the major source of norepinephrine (NE) in the brain...
- Mecp2 deficiency disrupts norepinephrine and respiratory systems in miceJean Charles Viemari
Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, Illinois 60637, USA
J Neurosci 25:11521-30. 2005..of variable duration; meanwhile, their medulla contained a significantly reduced number of TH neurons and norepinephrine (NE) content, even in Mecp2-/y mice that showed a normal breathing pattern...
- The QseC sensor kinase: a bacterial adrenergic receptorMarcie B Clarke
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
Proc Natl Acad Sci U S A 103:10420-5. 2006..AI-3 quorum-sensing system is also involved in interkingdom signaling with the eukaryotic hormones epinephrine/norepinephrine. This signaling activates transcription of virulence genes in enterohemorrhagic Escherichia coli O157:H7...
- Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NETAvner Schlessinger
Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 108:15810-5. 2011The norepinephrine transporter (NET) transports norepinephrine from the synapse into presynaptic neurons, where norepinephrine regulates signaling pathways associated with cardiovascular effects and behavioral traits via binding to ..
- Developmental origins of central norepinephrine neuron diversitySabrina D Robertson
Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Nat Neurosci 16:1016-23. 2013Central norepinephrine-producing neurons comprise a diverse population of cells differing in anatomical location, connectivity, function and response to disease and environmental insult...
- Decision making, the P3, and the locus coeruleus-norepinephrine systemSander Nieuwenhuis
Department of Cognitive Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Psychol Bull 131:510-32. 2005..authors review evidence suggesting that the P3 reflects phasic activity of the neuromodulatory locus coeruleus-norepinephrine (LC-NE) system...
- Current perspectives of the roles of the central norepinephrine system in anxiety and depressionAndrew W Goddard
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Depress Anxiety 27:339-50. 2010b>Norepinephrine (NE) is a major monoamine neurotransmitter that has widespread effects across multiple brain areas to regulate arousal and stress responses...
- Levomilnacipran (F2695), a norepinephrine-preferring SNRI: profile in vitro and in models of depression and anxietyA L Auclair
Neuropsychopharmacology Division, Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, 81106 Castres, France
Neuropharmacology 70:338-47. 2013Levomilnacipran (LVM; F2695) is the more active enantiomer of the serotonin/norepinephrine (5-HT/NE) reuptake inhibitor (SNRI) milnacipran and is currently under development for the treatment of major depressive disorder...
- Phasic norepinephrine: a neural interrupt signal for unexpected eventsPeter Dayan
Gatsby Computational Neuroscience Unit, University College London, London, UK
Network 17:335-50. 2006Extensive animal studies indicate that the neuromodulator norepinephrine plays an important role in specific aspects of vigilance, attention and learning, putatively serving as a neural interrupt or reset function...
- Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsisMichael Miksa
Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
PLoS ONE 4:e5504. 2009b>Norepinephrine (NE) modulates the responsiveness of macrophages to proinflammatory stimuli through the activation of adrenergic receptors (ARs)...
- Hindbrain noradrenergic A2 neurons: diverse roles in autonomic, endocrine, cognitive, and behavioral functionsLinda Rinaman
Dept of Neuroscience, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
Am J Physiol Regul Integr Comp Physiol 300:R222-35. 2011....
- The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA ("ecstasy") in humansC M Hysek
Psychopharmacology Research Group, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine and Department of Internal Medicine, University Hospital and University of Basel, Basel, Switzerland
Clin Pharmacol Ther 90:246-55. 2011This study assessed the pharmacodynamic and pharmacokinetic effects of the interaction between the selective norepinephrine (NE) transporter inhibitor reboxetine and 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in 16 healthy ..
- Heart rate variability, overnight urinary norepinephrine and C-reactive protein: evidence for the cholinergic anti-inflammatory pathway in healthy human adultsJ F Thayer
Department of Psychology, The Ohio State University, Columbus, OH 43210, USA
J Intern Med 265:439-47. 2009..Therefore, the objective of this study was to assess the immunomodulatory effects of the ANS...
- Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse linesJose A Morón
Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 22:389-95. 2002Selective blockers of the norepinephrine transporter (NET) inhibit dopamine uptake in the prefrontal cortex. This suggests that dopamine in this region is normally cleared by the somewhat promiscuous NET...
- Emotional enhancement of memory: how norepinephrine enables synaptic plasticityKeith Tully
Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, Massachusetts 02478, USA
Mol Brain 3:15. 2010Changes in synaptic strength are believed to underlie learning and memory. We explore the idea that norepinephrine is an essential modulator of memory through its ability to regulate synaptic mechanisms...
- Norepinephrine: The redheaded stepchild of Parkinson's diseaseK S Rommelfanger
Department of Human Genetics, Emory University, Atlanta, GA 30322, United States
Biochem Pharmacol 74:177-90. 2007..Historic and more recent experiments exploring the role of norepinephrine (NE) in PD will be analyzed in this review...
- Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 493:99-110. 2005Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in arousal, but recent findings suggest that this system plays a more complex and specific role in the control of behavior than investigators previously ..
- Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilienceJohn H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Brain Res 1293:13-23. 2009....
- Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasisMian M K Shahzad
Department of Gynecologic Oncology, RNA, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 285:35462-70. 2010..Here, we examined the molecular and biological significance of IL8 in stress-induced tumor growth. Norepinephrine (NE) treatment of ovarian cancer cells resulted in a 250-300% increase in IL8 protein and 240-320% increase in ..
- α7-cholinergic receptor mediates vagal induction of splenic norepinephrineGergely Vida
Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
J Immunol 186:4340-6. 2011..of both the vagus nerve and cholinergic agonists, and abrogate their potential to induce splenic and plasma norepinephrine. Splenic nerve stimulation mimics vagal and cholinergic induction of norepinephrine and re-establishes ..
- Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged womenJoel W Hughes
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3119, Durham, NC 27710, USA
J Psychosom Res 57:353-8. 2004..The primary goal of this study was to evaluate the relationship between levels of self-reported symptoms of depression and anxiety and 24-hour urinary catecholamine excretion...
- Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitorsJohn F Cryan
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 101:8186-91. 2004Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited by different ..
- M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminalsMaria Martire
Institute of Pharmacology, School of Medicine, Catholic University of Sacred Heart, 00168 Rome, Italy
J Neurosci 24:592-7. 2004..These findings provide novel evidence for a major regulatory role of KCNQ2 K+ channel subunits in neurotransmitter release from rat hippocampal nerve endings...
- Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortexFrank P Bymaster
Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
Psychopharmacology (Berl) 160:353-61. 2002..has been shown to not only increase the extracellular concentrations of serotonin, but also dopamine and norepinephrine extracellular concentrations in rat prefrontal cortex...
- Renalase deficiency in heart failure model of rats--a potential mechanism underlying circulating norepinephrine accumulationRong Gu
Department of Cardiology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
PLoS ONE 6:e14633. 2011..Here, we identify a potential mechanism underlying norepinephrine accumulation in a rat model of heart failure.
- There and back again: a tale of norepinephrine and drug addictionDavid Weinshenker
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 32:1433-51. 2007Fueled by anatomical, electrophysiological, and pharmacological analyses of endogenous brain reward systems, norepinephrine (NE) was identified as a key mediator of both natural and drug-induced reward in the late 1960s and early 1970s...
- Modeling a negative response bias in the human amygdala by noradrenergic-glucocorticoid interactionsJuraj Kukolja
Cognitive Neurology Section, Institute of Neuroscience and Biophysics Medicine, Research Centre Juelich, 52425 Juelich, Germany
J Neurosci 28:12868-76. 2008..Acute stress leads to increased central levels of norepinephrine (NE) and cortisol (CORT), and evidence suggests that these endogenous neuromodulators synergistically ..
- Norepinephrine enables the induction of associative long-term potentiation at thalamo-amygdala synapsesKeith Tully
Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 104:14146-50. 2007Emotional arousal, linked to a surge of norepinephrine (NE) in the amygdala, leads to creation of stronger and longer-lasting memories. However, little is known about the synaptic mechanisms of such modulatory NE influences...
- Sympathetic augmentation in hypertension: role of nerve firing, norepinephrine reuptake, and Angiotensin neuromodulationMarkus P Schlaich
Department of Medicine IV, University of Erlangen Nuernberg, Krankenhausstr 12, 91054 Erlangen, Germany
Hypertension 43:169-75. 2004..Potential mechanisms include increased central sympathetic outflow, altered norepinephrine (NE) neuronal reuptake, diminished arterial baroreflex dampening of sympathetic nerve traffic, and sympathetic ..
- (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride (tapentadol HCl): a novel mu-opioid receptor agonist/norepinephrine reuptake inhibitor with broad-spectrum analgesic propertiesThomas M Tzschentke
Department of Pharmacology, Grunenthal GmbH, Aachen, Germany
J Pharmacol Exp Ther 323:265-76. 2007..It is suggested that the broad analgesic profile of tapentadol and its relative resistance to tolerance development may be due to a dual mode of action consisting of both MOR activation and NE reuptake inhibition...
- Norepinephrine precursor therapy in neurogenic orthostatic hypotensionHoracio Kaufmann
Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
Circulation 108:724-8. 2003In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture.
- Selective norepinephrine reuptake inhibition as a human model of orthostatic intoleranceChristoph Schroeder
Clinical Research Center, Helios Klinkum Berlin, Germany
Circulation 105:347-53. 2002Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance.
- Effects of aging and hypertension on the participation of endothelium-derived constricting factor (EDCF) in norepinephrine-induced contraction of rat femoral arterySilvia Liskova
Center of Cardiovascular Research and Institute of Physiology, Academy of Sciences of Czech Republic, Prague, Czech Republic
Eur J Pharmacol 667:265-70. 2011..The contribution of endothelium-derived constricting factor (EDCF) to norepinephrine-induced contraction is still unknown...
- CSF norepinephrine concentrations in posttraumatic stress disorderT D Geracioti
Mental Health Service, Veterans Affairs Medical Center, 3200 Vine St, Cincinnati, OH 45220, USA
Am J Psychiatry 158:1227-30. 2001..nervous system (CNS) noradrenergic activity in posttraumatic stress disorder (PTSD), direct measures of CNS norepinephrine in PTSD have been lacking...
- Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptorsZizhen Zhang
Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
PLoS ONE 8:e66122. 2013Optimal norepinephrine levels in the prefrontal cortex (PFC) increase delay-related firing and enhance working memory, whereas stress-related or pathologically high levels of norepinephrine are believed to inhibit working memory via α1 ..
- Exercise in fibromyalgia and related inflammatory disorders: known effects and unknown chancesE Ortega
Department of Physiology, Faculty of Sciences, University of Extremadura, Badajoz, Spain
Exerc Immunol Rev 15:42-65. 2009..A better regulation of the cytokine-HPA axis feedback may be also involved...
- Maternal hen calls modulate memory formation in the day-old chick: the role of noradrenalineS E Field
School of Psychology, Psychiatry and Psychological Medicine, Monash University, VIC 3800, Australia
Neurobiol Learn Mem 88:321-30. 2007..The current data suggest that call meaning and rhythmicity interact to yield the appropriate levels of beta(2)-adrenergic activation required to facilitate retention for a discriminative task...
- Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibitionMelanie Clarke
Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada
PLoS ONE 7:e44073. 2012..Thus, endogenous JNK appears to affect stress relevant processes in a context-dependent manner...
- Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performanceJohn O'Donnell
Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Neurochem Res 37:2496-512. 2012b>Norepinephrine (NE) is a neuromodulator that in multiple ways regulates the activity of neuronal and non-neuronal cells...
- Norepinephrine and dopamine modulate impulsivity on the five-choice serial reaction time task through opponent actions in the shell and core sub-regions of the nucleus accumbensDaina Economidou
Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 37:2057-66. 2012..Although dopamine (DA) and norepinephrine (NE) have a significant role in the modulation of impulsivity their neural loci of action is not well ..
- Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in ratsKen ichiro Hayashida
Department of Anesthesiology and Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Pain 136:348-55. 2008Many treatments for neuropathic pain activate or augment norepinephrine release in the spinal cord, yet these treatments are less effective against acute nociceptive stimuli...
- The role of dopamine and norepinephrine in depression and antidepressant treatmentDavid J Nutt
Psychopharmacology Unit, School of Medical Sciences, University of Bristol, Bristol, UK
J Clin Psychiatry 67:3-8. 2006..Through the past several decades, approaches undertaken to clarify the roles of the neurotransmitters norepinephrine, dopamine, and serotonin in depression have included animal studies, human biological and postmortem studies, ..
- Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in ratsHideaki Obata
Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa, Maebashi, Gunma 371 8511, Japan
J Pharmacol Exp Ther 334:1059-65. 2010..Combined administration of an SNRI with morphine might be a promising treatment to suppress postoperative hypersensitivity...
- Renal sympathoinhibition induced by hypernatremia: involvement of A1 noradrenergic neuronsGustavo Rodrigues Pedrino
Department of Physiology, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, SP, Brazil
Auton Neurosci 142:55-63. 2008..These results suggest that A1 noradrenergic neurons are involved in the sympathoinhibition and consequent renal vasodilatation to acute changes in the extracellular fluid compartment...
- Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent ratsNicholas W Gilpin
Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, SP30 2400 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
Psychopharmacology (Berl) 212:431-9. 2010..display enhanced stress responsivity, reward thresholds, and alcohol self-administration during alcohol withdrawal, and some of these aspects of alcohol dependence may be mediated by activation of brain norepinephrine (NE) systems.
- Neural mechanisms of paroxysmal atrial fibrillation and paroxysmal atrial tachycardia in ambulatory caninesAlex Y Tan
Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Circulation 118:916-25. 2008..The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear...
- Baseline psychological stress and ovarian norepinephrine levels negatively affect the outcome of in vitro fertilisationXiao Hong Li
Reproductive Medical Center of West China 2nd Hospital, Sichuan University, Ren Min Nan Lu, City of Chengdu, Sichuan, 610041, People s Republic of China
Gynecol Endocrinol 27:139-43. 2011We determined the effect of baseline psychological stress and norepinephrine (NE) levels in the follicular fluid on the outcome of in vitro fertilisation (IVF).
- Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractionsJayme R McReynolds
School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080 3021, USA
Neurobiol Learn Mem 93:312-21. 2010..rats immediately after inhibitory avoidance training to examine effects on long-term memory, amygdala norepinephrine levels, and hippocampal Arc expression...
- Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failureYu Ming Kang
Univ of Iowa College of Medicine, Iowa City, IA 52242, USA
Am J Physiol Heart Circ Physiol 295:H227-36. 2008..VEH-treated HF rats had higher plasma levels of norepinephrine, ANG II, interleukin (IL)-1beta, and adrenocorticotropic hormone, increased left ventricular end-diastolic ..
- Altered sympathetic nervous reactivity and norepinephrine transporter expression in patients with postural tachycardia syndromeElisabeth Lambert
Human Neurotransmitter Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
Circ Arrhythm Electrophysiol 1:103-9. 2008Clinical observations in patients with postural tachycardia syndrome (POTS) suggest abnormal sympathetic nervous system activity and a dysfunction of the norepinephrine (NE) transporter (NET).
- Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxietyJesse R Schank
Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
Biol Psychiatry 63:1007-12. 2008..While the mechanisms underlying cocaine's rewarding effects have been studied extensively, less attention has been paid to the unpleasant behavioral states induced by cocaine, such as anxiety...
- CRF₂ mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in ratsJavier Navarro-Zaragoza
Group of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain
Br J Pharmacol 162:851-62. 2011....
- Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrineTracy J Horton
Section of Nutrition, Dept of Pediatrics, Univ of Colorado Denver, Campus Box C225, 12700 East 19th Ave, Aurora, CO 80045, USA
J Appl Physiol (1985) 107:200-10. 2009..men (n = 10) were recruited and studied on 3 separate days with the following infusions: epinephrine (Epi), norepinephrine (NE), or the two combined...
- Norepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via β-adrenergic receptor-dependent activation of P38/MAPK pathwayXin Yu Huang
Department of Surgery, Shanghai Jiaotong University, Shanghai, China
Hepatogastroenterology 59:889-93. 2012..This study aims to examine the effect of stress hormone norepinephrine (NE) on proliferation, migration and invasion of human pancreatic cancer cells and the molecular pathway ..
- Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramineZaorui Zhao
Graduate Program in Pharmaceutical and Pharmacological Sciences, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA
Neuropsychopharmacology 33:3190-200. 2008The relationship between the ability of repeated desipramine treatment to cause downregulation of the norepinephrine transporter (NET) and produce antidepressant-like effects on behavior was determined...
- Catecholamine mapping within nucleus accumbens: differences in basal and amphetamine-stimulated efflux of norepinephrine and dopamine in shell and coreChristina R McKittrick
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA
J Neurochem 100:1247-56. 2007..We used in vivo microdialysis to measure extracellular levels of both norepinephrine and dopamine in the accumbens shell and core...
- Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholiaPhilip W Gold
Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1284, USA
Proc Natl Acad Sci U S A 102:8303-8. 2005..The mortality of chronic heart failure (CHF) doubles either when CHF patients are depressed or when their plasma norepinephrine (NE) level exceeds those of controls by approximately 40%...
- Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal glandRodrigo Antonio Peliciari Garcia
University of Sao Paulo, Institute of Biomedical Sciences, Department of Physiology and Biophysics, Av Prof Lineu Prestes 1524, 1st Floor, Room 118, Sao Paulo, SP, CEP 05508 900, Brazil
Life Sci 82:108-14. 2008..The aim of the current study was to determine whether insulin modulates norepinephrine (NE)-mediated melatonin synthesis...
- The human sympathetic nervous system: its relevance in hypertension and heart failureGianfranco Parati
Department of Cardiology, S Luca Hospital, IRCCS Istituto Auxologico Italiano, piazza Brescia 20, 20149 Milan, Italy
Eur Heart J 33:1058-66. 2012....
- Layer-specific noradrenergic modulation of inhibition in cortical layer II/IIIHumberto Salgado
Laboratory of Cell and Synaptic Physiology, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USA
Cereb Cortex 21:212-21. 2011b>Norepinephrine (NE) is released in the neocortex after activation of the locus coeruleus of the brain stem in response to novel, salient, or fight-or-flight stimuli...
- Norepinephrine suppresses wound macrophage phagocytic efficiency through alpha- and beta-adrenoreceptor dependent pathwaysAnkush Gosain
Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, Ill, USA
Surgery 142:170-9. 2007The systemic response to injury is characterized by massive release of norepinephrine (NE) into the circulation as a result of global sympathetic activation...
- Regulation of the norepinephrine transporter by alpha-synuclein-mediated interactions with microtubulesALEXIS M JEANNOTTE
Department of Biochemistry and Molecular and Cell Biology, Georgetown University, Washington, DC 20007, USA
Eur J Neurosci 26:1509-20. 2007..We demonstrate that alpha-Syn regulates the activity and surface expression of the norepinephrine transporter (NET), depending on its expression levels...
- Noradrenergic deficits alter processing of communication signals in female songbirdsKathleen S Lynch
Johns Hopkins University, Department of Psychological and Brain Sciences, Baltimore, Maryland 21211, USA
Brain Behav Evol 72:207-14. 2008..Overall, our results reveal that noradrenaline plays a significant neuromodulatory role during the reception of species-typical communication signals...
- A distinct role for norepinephrine in memory retrievalCharles F Murchison
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 117:131-43. 2004A role for norepinephrine in learning and memory has been elusive and controversial. A longstanding hypothesis states that the adrenergic nervous system mediates enhanced memory consolidation of emotional events...
- Inhibition of β-adrenergic receptors induces a persistent deficit in retrieval of a cocaine-associated memory providing protection against reinstatementJames M Otis
Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI, USA
Neuropsychopharmacology 36:1912-20. 2011..Thus, retrieval of cocaine-associated memories is mediated by norepinephrine acting at central β-adrenergic receptors...
- Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cellsHussein A N Al-Wadei
Experimental Oncology Laboratory, University of Tennessee, Knoxville, TN 37996, USA
Lung Cancer 69:33-9. 2010..This selective imbalance in stimulatory and inhibitory signaling may contribute to the development and progression of small airway-derived adenocarcinoma in women who smoke...
- BMP signaling regulates sympathetic nervous system development through Smad4-dependent and -independent pathwaysYuka Morikawa
Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
Development 136:3575-84. 2009....
- Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overloadNina Kaludercic
Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Circ Res 106:193-202. 2010Monoamine oxidases (MAOs) are mitochondrial enzymes that catabolize prohypertrophic neurotransmitters, such as norepinephrine and serotonin, generating hydrogen peroxide...
- Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cellsDaniel G Bernabé
Oral Oncology Center, School of Dentistry of Aracatuba, Unesp Univ Estadual Paulista, Aracatuba, Sao Paulo, Brazil
Brain Behav Immun 25:574-83. 2011..The effects of norepinephrine (NE), and cortisol were studied in SCC9, SCC15, and SCC25 cells and effects of isoproterenol in SCC9 and SCC25 ..
- Role of brain norepinephrine in the behavioral response to stressDavid A Morilak
Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 78229 3900, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:1214-24. 2005The brain noradrenergic system is activated by acute stress. The post-synaptic effects of norepinephrine (NE), exerted at a cellular or neural circuit level, have been described as modulatory in nature, as NE facilitates responses evoked ..
- Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progressionEric V Yang
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA
Brain Behav Immun 23:267-75. 2009..The catecholamine stress hormone, norepinephrine (NE), may influence tumor progression by modulating the expression of factors implicated in angiogenesis and ..
- Molecular modulation of prefrontal cortex: rational development of treatments for psychiatric disordersNao J Gamo
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
Behav Neurosci 125:282-96. 2011..In this review, we discuss the molecular signaling events initiated by norepinephrine and dopamine that strengthen working memory function mediated by the dorsolateral PFC under optimal conditions,..
- Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat heartsSatoshi Yamamoto
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Osaka, Japan
Circulation 111:302-9. 2005Endothelin (ET)-1 and norepinephrine (NE) are involved in myocardial ischemia/reperfusion injury...
- The effects of peripheral vagal nerve stimulation at a memory-modulating intensity on norepinephrine output in the basolateral amygdalaD L Hassert
Department of Psychology, University of Virginia, Charlottesville, VA 22904 4400, USA
Behav Neurosci 118:79-88. 2004..It has long been assumed that these effects are related to stimulation-induced increases of norepinephrine (NE) release in limbic brain structures...
- Effect of chronic treatment with propranolol on the cardiovascular responses to chronic cold exposureZ Sun
Department of Physiology, College of Liberal Arts and Sciences, University of Florida, Gainesville 32610, USA
Physiol Behav 62:379-84. 1997..Propranolol, however, did not affect cold-induced cardiac hypertrophy...
- The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transportersSuzanne M Cloonan
School of Biochemistry and Immunology, Trinity College Dublin, Ireland
Leuk Lymphoma 51:523-39. 2010The discovery that some selective serotonin transporter- (SSRI) and norepinephrine transporter- (NSRI) targeting antidepressants have the potential to act as anticancer agents adds greatly to their diverse pharmacological application...
- Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk?David A Barton
Human Neurotransmitter Laboratory, Australia
J Hypertens 25:2117-24. 2007..Evidence exists linking major depressive disorder (MDD) with clinical cardiovascular events. The importance of the sympathetic nervous system in the generation of cardiac risk in other contexts is established...
- Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failureKersten M Small
Division of Pulmonary Medicine, University of Cincinnati College of Medicine, Cincinnati 45267 0564, USA
N Engl J Med 347:1135-42. 2002..Release of norepinephrine is controlled by negative feedback from presynaptic alpha2-adrenergic receptors, and the targets of the ..
- What birdsong can teach us about the central noradrenergic systemChristina B Castelino
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, United States
J Chem Neuroanat 39:96-111. 2010..These include the ability to investigate the effect of norepinephrine on synaptic function using brain slices, identifying its influence on singing-related gene expression and ..
- Altered central catecholaminergic transmission and cardiovascular diseaseS Kasparov
Department of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK
Exp Physiol 93:725-40. 2008..These studies may reveal new therapeutic strategies for various cardiovascular diseases which are accompanied by heightened sympathetic nerve activity...
- Inhibitory effects of halothane on the thermogenic pathway in brown adipocytes: localization to adenylyl cyclase and mitochondrial fatty acid oxidationKerstin B E Ohlson
The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
Biochem Pharmacol 68:463-77. 2004..efficiently inhibit nonshivering thermogenesis as well as the cellular manifestation of that phenomenon: norepinephrine-induced respiration in brown adipocytes...
- Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousalB J Cole
Department of Experimental Psychology, University of Cambridge, U K
Behav Brain Res 33:165-79. 1989..They therefore complete a double dissociation of effects on accuracy and vigour of responding, supporting theories of a division of arousal-type processes...
- Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleusE J van Bockstaele
Department of Pathology, Anatomy and Cell Biology, Suite 520, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Physiol Behav 73:273-83. 2001..of the locus coeruleus (LC) respond in parallel to a variety of stress-related stimuli which results in norepinephrine release both peripherally and centrally...
- Restraining influence of A2 neurons in chronic control of arterial pressure in spontaneously hypertensive ratsHanad Duale
Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University Walk, University of Bristol, Bristol, BS8 1TD, UK
Cardiovasc Res 76:184-93. 2007..We aimed to genetically target A2 neurons and induce expression of a potassium channel to reduce their electrical excitability and study how this impacts on long-term blood pressure control...
- Catecholamine influences on prefrontal cortical function: relevance to treatment of attention deficit/hyperactivity disorder and related disordersAmy F T Arnsten
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Pharmacol Biochem Behav 99:211-6. 2011..known to be especially sensitive to its neurochemical environment; relatively small changes in the levels of norepinephrine and dopamine can produce significant changes in its function...
- MPTP and MPP+ target specific aminergic cell populations in larval zebrafishV Sallinen
Neuroscience center and Institute of Biomedicine Anatomy, Haartmaninkatu, University of Helsinki, Helsinki, Finland
J Neurochem 108:719-31. 2009..The results suggest that MPTP and MPP+ induce a transient functional deficit and motility disorder in larval zebrafish...
- Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitisZhiping Li
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Hepatology 40:434-41. 2004..NKT cells express adrenoceptors. Thus, we hypothesize that the low norepinephrine (NE) activity of ob/ob mice promotes depletion of liver NKT cells, thereby sensitizing ob/ob livers to ..
- Emotion enhances learning via norepinephrine regulation of AMPA-receptor traffickingHailan Hu
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Cell 131:160-73. 2007Emotion enhances our ability to form vivid memories of even trivial events. Norepinephrine (NE), a neuromodulator released during emotional arousal, plays a central role in the emotional regulation of memory...
- Noradrenergic inputs mediate state dependence of auditory responses in the avian song systemJessica A Cardin
Department of Biology and Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:7745-53. 2004b>Norepinephrine (NE) plays a complex role in the behavioral state-dependent regulation of sensory processing. However, the role of forebrain NE action in modulating high-order sensory activity has not been directly addressed...
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010Aberrant norepinephrine [NE] neurotransmission in the human brain is linked to mood disorders, depression, drug addiction and neurodegenerative diseases...
- Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNSArnold E Postlethwaite; Fiscal Year: 2010..with rheumatoid arthritis (RA) and is associated with activation of the sympathetic nervous system releasing norepinephrine which activates the immune system, scleroderma, lupus and other autoimmune diseases...
- Ghrelin: Behavioral, Anatomical, and Physiological Components of ObesityBRETT JOHN WARREN TEUBNER; Fiscal Year: 2011..and measure BAT temperature, uncoupling protein-1 (the critical factor for BAT thermogenesis) protein, and norepinephrine turnover rate (NETO, a neurochemical measure of SNS drive) and from WAT, and two SNS-induced intracellular ..
- Mechanisms of Vasovagal SyncopeJulian M Stewart; Fiscal Year: 2013..neurotransmission will be assessed by step wise tyramine doses using HPLC analysis of microdialysate norepinephrine (NE)...
- IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERSDennis G Drescher; Fiscal Year: 2013..We will investigate norepinephrine-containing adrenergic efferents constituting a newly-recognized neural system operating within the organ of ..
- Novel treatment of menopausal hot flushes with an estradiol prodrugLaszlo Prokai; Fiscal Year: 2012..or hormone (estrogens + progestins) therapies (ERT and HRT), clonidine, the selective serotonin and/or norepinephrine reuptake inhibitors, and gabapentine...
- Phospholipid-Mediated Metabolic Control in Liver and Brown Adipose TissueDavid E Cohen; Fiscal Year: 2013..Cultured brown adipocytes wil also be used to evaluate whether PC-TP-Them2 interactions reduce norepinephrine signaling by increasing oxidative stress...
- Inducible recombination and gene expression in specific neurotransmitter systemsSteven A Thomas; Fiscal Year: 2012..The four are the adrenergic (norepinephrine and epinephrine), dopaminergic, serotonergic and orexinergic systems...
- Steroid Regulation of Serotonin in MalesCYNTHIA LOUISE BETHEA; Fiscal Year: 2013..indication of serotonin neurotransmission, and to obtain preliminary support for the potential involvement of norepinephrine. Together, these experiments will further our understanding of the regulation of the serotonin system in male ..
- Metal Exposure and Children?s Preschool NeurodevelopmentDavid C Bellinger; Fiscal Year: 2012..metabolism (apolipoprotein E), neurotransmitter metabolism (dopamine transporter, dopamine D4 receptor, norepinephrine transporter, monoamine oxidase, catechol O-methyltransferase, NMDA receptor, 5-HT1A receptor), and methylation ..
- Developmental Regulation of Brain and BehaviorJULI S WADE; Fiscal Year: 2011..Aim 3 will evaluate a set of mechanistic hypotheses regarding the roles of E2, norepinephrine (NE), BDNF, and the three sex chromosome genes (trkB, SCAMP1 and SNX2)...
- Regulation of Innate Immunity by the Sympathetic Nervous System Druing SepsisEric J Seeley; Fiscal Year: 2013..Preliminar studies indicate that decreasing the release of norepinephrine, a compound released from sympathetic nerves during stress, improves survival in mouse models of infection...
- Quorum sensing regulation of EHEC virulence genesVanessa Sperandio; Fiscal Year: 2013..aromatic autoinducer (AI-3) produced by the normal gastrointestinal flora, and two hormones (epinephrine/norepinephrine) produced by the host...
- Sex Differences in Stress Receptors Underlie Female Vulnerability to StressDebra A Bangasser; Fiscal Year: 2012..Corticotropin-releasing factor (CRF) orchestrates stress responses, in part, by regulating norepinephrine (NE) and serotonin (5-HT) transmission, and CRF is dysregulated in stress-related disorders...
- Molecular mechanisms of bacterial homologs of neurotransmitter:sodium symportersJonathan A Javitch; Fiscal Year: 2013..NSS include the transporters for dopamine, serotonin and norepinephrine-targets for amphetamine, cocaine, and antidepressant drugs-as well as the transporters for GABA and glycine, ..
- GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASERohit Loomba; Fiscal Year: 2013..system has a strong genetic association with HTN, IR &TG;and in-vitro and in-vivo studies suggest that norepinephrine (increased adrenergic activity) activates hepatic stellate cells &induces fibrogenesis in mice model of ..
- Endothelial Lipoxygenase Metabolites and Vascular ToneWILLIAM BRYSON CAMPBELL; Fiscal Year: 2013..Agonists such as norepinephrine and angiotensin promote constriction by activating the RhoA-Rho kinase cascade that sensitizes contractile ..
- How do Amine Neurons Work?Edward A Kravitz; Fiscal Year: 2013..attention-deficit hyperactivity disorder and drug abuse in which the amines dopamine, serotonin and norepinephrine all have been directly implicated...
- Spinal Cord-Mediated Acute Neurogenic InflammationQing Lin; Fiscal Year: 2010..Specific Aim 4 is to examine if sympathetic effects on neurogenic inflammation by release of norepinephrine and adenosine 5'-triphosphate are done by modulating the function of TRPNA, receptors via the PKC cascade...
- Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and CalcineurinWilliam A Sather; Fiscal Year: 2010..In hippocampal pyramidal neurons, norepinephrine binding to beta adrenergic receptors initiates a cascade that leads to cAMP production and PKA activation...
- Mechanisms of airborne particulate matter induced thrombosisGokhan M Mutlu; Fiscal Year: 2013..We also observed that mice exposed to inhaled PM had increased lung and systemic levels of epinephrine and norepinephrine, directly confirming data from human exposure studies suggesting that PM exposure activates the sympathetic ..
- Pharmacological Management of DeliriumMalaz Boustani; Fiscal Year: 2013..Disturbances in several neurotransmitters, such as acetylcholine, dopamine, glutamate, serotonin, norepinephrine, and gamma-aminobutyric acid (GABA), have been suggested to be involved in the pathophysiology of delirium...
- Adolescent Alcohol,Dysregulated Stress System, and PTSD VulnerabilityGERHARD H SCHULTEIS; Fiscal Year: 2013..A further prediction is that corticotropin releasing factor (CRF) and/or norepinephrine (NE) systems in the CNS are central to the potentiative effects of ethanol exposure and withdrawal on PTSD ..
- Sex Differences in Stress Receptors Underlie Female Vulnerability to StressDebra A Bangasser; Fiscal Year: 2013..Corticotropin-releasing factor (CRF) orchestrates stress responses, in part, by regulating norepinephrine (NE) and serotonin (5-HT) transmission, and CRF is dysregulated in stress-related disorders...
- Chronic stress-induced gene expression in colonic circular smooth muscle cells.Sushil K Sarna; Fiscal Year: 2012..The primary mediators of the stress response are: corticotropin releasing hormone, norepinephrine, glucocorticoids and the neurotransmitters of the autonomic nervous system...
- Ecstasy and the Dorsomedial HypothalamusDaniel E Rusyniak; Fiscal Year: 2010..Along with physiologic similarities, the DMH is an anatomic area rich in norepinephrine and dopamine, both integral in mediating MDMA's effects...
- Mechanisms of abnormal enterochromaffin cell secretion in Crohn's diseaseMark S Kidd; Fiscal Year: 2012..is altered in Crohn's by: 1) determining whether 5HT, substance P and guanylin secretion is regulated by norepinephrine, mechanic forces somatostatin analogs and acetylcholine in Crohn's EC cells;2) determining if [unreadable]..
- Histamine Receptor Norepinephrine in Cardiac DysfunctionRoberto Levi; Fiscal Year: 2013..a) how ischemic preconditioning prevents the activation of the mast cell-dependent RAS, thus alleviating norepinephrine- and angiotensin-induced arrhythmias;and, b) how H3-receptor activation mimics the cardioprotective anti-RAS ..
- Cognitive Behavioral Therapy for Insomnia in Stable Heart FailureNancy S Redeker; Fiscal Year: 2010..We will also obtain day and night measures of urinary free cortisol, free epinephrine/norepinephrine, and melatonin sulfate...
- CRF and Stress Modulation of Phasic Dopamine Release and BehaviorMATTHEW J WANAT; Fiscal Year: 2013..Emerging evidence suggests that catecholamine (dopamine and norepinephrine) release in the prefrontal cortex and amygdala are also involved with mediating the response to stress, so the ..
- Central Nervous System Mechanisms in Knee Osteoarthritis (KOA)Daniel J Clauw; Fiscal Year: 2013..RCTs have demonstrated that compounds that alter pain neurotransmitters centrally such as 15,16 serotonin and norepinephrine (e.g., duloxetine, tricyclics) are efficacious in OA ...
- Mechanisms of Neurotransmitter BiosynthesisPaul F Fitzpatrick; Fiscal Year: 2011..hydroxylase results in phenylketonuria;tyrosine hydroxylase is required to make the neurotransmitters dopamine, norepinephrine, and epinephrine;and tryptophan hydroxylase is required to synthesize the neurotransmitter serotonin.
- A Genetic Model for Understanding the Metabolic Syndrome/Obesity RelationshipBENJAMIN JENNINGS RENQUIST; Fiscal Year: 2010..2007). Aim 1 will examine sensitivity to ip injected ^-agonists and antagonists, identify basal norepinephrine (NE) and NE turnover in WAT of WT, MC4-R -/-, and MC3-R -/- mice, and identify the role pharmacological ..
- The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose TissueROBERT STANLEY SHERWIN; Fiscal Year: 2012..We propose to use a structural feature of the sympathetic nervous system, and image the norepinephrine recycling component, designated the norepinephrine transporter (NET)...
- Octopamine Neuroanatomy and Functioning in Fruit Fly Social BehaviorKYLE LYNN GOBROGGE; Fiscal Year: 2013..Interestingly, the phenol analogue of norepinephrine - octopamine (OA), which is commonly found in invertebrate species, was recently found to play a critical role ..
- Interactions of MAO A with vulnerability factors for aggressionMarco Bortolato; Fiscal Year: 2012..activity of brain monoamine oxidase (MAO) A, the major enzyme for the degradation of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA);male gender, in relation to the high levels of androgen testosterone and its ..
- Intervention for Menstrual Mood Disorders &Early Life Abuse: Biopsych MechanismsSusan S Girdler; Fiscal Year: 2013..at rest and in response to mental stress: 1) sympathetic nervous system (blood pressure, heart rate, plasma norepinephrine and epinephrine);2) hypothalamic-pituitary-adrenal (plasma ACTH and cortisol);3) inflammatory (plasma IL-6);..
- RENALASE DEFICIENCY AND CARDIOVASCULAR COMPLICATIONS OF CHRONIC KIDNEY DISEASEGary V Desir; Fiscal Year: 2010..by either modest increases in blood pressure and/or brief surges in either plasma dopamine, epinephrine or norepinephrine. The active enzyme specifically degrades circulating catecholamines in vivo, causing a significant fall in ..
- smFRET Investigation of Gating in a Neurotransmitter Transporter HomologRACHEL ANN KOLSTER; Fiscal Year: 2013..The neurotransmitter: sodium symporter (NSS) family includes the transporters for serotonin, dopamine, and norepinephrine, which are targeted by antidepressants, methylphenidate (Ritalin), and the widely abused psychostimulants ..
- Hormonal Modulation of Aggression in DrosophilaEdward A Kravitz; Fiscal Year: 2013..focus on two major amines found in the fruit fly nervous system: octopamine (OA), the phenol analogue of norepinephrine, is the major amine synthesized from tyrosine;and serotonin (5HT), is the major amine derived from tryptophan...
- Neurotrophins and Post-infarct Plasicity in Cardiac Sympathetic NeuronsBeth A Habecker; Fiscal Year: 2013..First are key neurotransmitter and neuropeptide changes, as extracellular norepinephrine (NE) increases together with neuronal expression of the peptides galanin and PACAP (pituitary adenylate ..
- SERT KO rats are a model of sex specific visceral painJames J Galligan; Fiscal Year: 2013..IHC localization of the dopamine and norepinephrine transporters and organic cation transporters will be assessed to determine if their expression increases in ..
- NUTRITIONAL COPPER STATUS AND THE NERVOUS SYSTEMJOSEPH ROBERT PROHASKA; Fiscal Year: 2010..4-dihydroxyphenvlserine (L-DOPS) to bypass the DBM step and restore low brain norepinephrine. AIM 2: We will test the hypothesis that limitation in Cu...
- Using Electrochemical Methods to Probe Neuronal Signaling in the GI TractGreg M Swain; Fiscal Year: 2010..We also propose to expand the scope of the studies to include dopamine (DA) and norepinephrine (NE) released in the myenteric plexus...
- Modulation of Hepatocellular Function in SepsisPing Wang; Fiscal Year: 2013..Furthermore, norepinephrine directly upregulates CIRP expression, while nicotine decreases endotoxin-induced CIRP expression in isolated ..
- The geriatric surgical patient: stress, anesthetics, and functional outcomesStacie Deiner; Fiscal Year: 2012..with a lesser activation of the stress response as evidenced by serum cortisol, lower plasma levels of norepinephrine (NE), epinephrine (E), and growth hormone (GH), and lesser heart rate variability (HRV)...
- NORADRENERGIC SYSTEM IN DEPRESSIONGREGORY ALLEN ORDWAY; Fiscal Year: 2012Both human and laboratory animal research findings strongly implicate brain noradrenergic overactivity and norepinephrine (NE) depletion in the neuropathology of major depressive disorder (MDD)...
- FETAL AND NEONATAL NEUROBEHAVIOR AND PRENATAL ANTIDEPRESSANT EXPOSURE: THE CHILDAmy L Salisbury; Fiscal Year: 2013..Serotonin/Norepinephrine Reuptake Inhibitors (SRIs), antidepressant medications remain the most commonly chosen treatment for MDD ..
- Negative symptoms of schizophrenia: animal modelsAthina Markou; Fiscal Year: 2013..pharmacological treatments probing specific neurotransmitter and receptor systems, including serotonin, norepinephrine, glutamate, and GABA, may reverse PCP-induced cognitive deficits...
- AT2 Receptors in the RVLM: Regulation of Sympathetic Outflow in Heart FailureLie Gao; Fiscal Year: 2013..of over expressing AT2R in the RVLM on arterial blood pressure (AP), heart rate (HR), cardiac function, and norepinephrine excretion in conscious normal and CHF rats...
- Radiation Combined Injury: Mechanisms and Therapeutic ApproachesPing Wang; Fiscal Year: 2012..Ghrelin inhibits the sympathetic nervous system, as evidenced by the reduction of norepinephrine (NE) release and inactivation of sympathostimulatory neurons in the brain in sepsis...
- Right Heart Function in Health and Chronic Lung DiseaseAnthony J Baker; Fiscal Year: 2013..We found that in failing RV the inotropic response to norepinephrine (NE, a mixed 1/2 agonist) was appreciably increased, despite downregulation of 2-responses;thus, suggesting ..
- Recognition of host catecholamines in Borrelia burgdorferi gene regulationLinden T Hu; Fiscal Year: 2010..In our preliminary studies, we have identified the first host molecule, the adrenergic hormone norepinephrine (NE), which is recognized by B. burgdorferi as a signal for a specific environmental change...
- Conformational Changes Underlying Intracellular Gating of the Leucine TransporterKelli Kazmier; Fiscal Year: 2012..NSS members including human dopamine, serotonin, and norepinephrine transporters harness sodium and chloride gradients to facilitate reuptake of neurotransmitters from the ..
- Modeling Individual Differences in PTSDMarlene A Wilson; Fiscal Year: 2013..of hypothalamic-pituitary- adrenal (HPA) activity and other indices of sympathetic activation including norepinephrine (NE) and epinephrine (EPI) levels...
- Locus Coeruleus-Norepinephrine System Regulation of Prepulse InhibitionVaishali P Bakshi; Fiscal Year: 2010..Nevertheless, there is a striking gap in knowledge about the role of the norepinephrine (NE) system in regulating PPI...
- Synaptic basis of perceptual learning in primary auditory cortexROBERT CROOKS FROEMKE; Fiscal Year: 2013..thalamic plasticity for enhancing auditory perception when sounds are paired with the powerful neuromodulator norepinephrine. Norepinephrine is important for selective attention, general arousal, and learning, is a major factor in ..
- Cell-Cell Interactions in Thrombosis -Request for Extension of Merit AwardAARON JACOB MARCUS; Fiscal Year: 2013..11Studies of the effects of NTPDases on cell-cell signaling during ischemia: Modulation of norepinephrine release by NTPDases from cardiac sympathetic nerve endings (cSNE) and isolated hearts from guinea pigs, wild ..
- Biogenic Amine Transporters: Mechanisms of Ligand InteractionMAARTEN E REITH; Fiscal Year: 2013..Other biogenic amine transporters are the serotonin transporter (SERT) and the norepinephrine transporter (NET), targets for many different antidepressant drugs...
- Alpha-1A-adrenergic agonist therapy for cardiomyopathy and heart failurePaul C Simpson; Fiscal Year: 2013..The catecholamines norepinephrine (NE) and epinephrine (EPI) activate two types of ARs on cardiac muscle cells, the dominant beta-ARs, which ..
- MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENTMichael D Gershon; Fiscal Year: 2013..neurons, which are among the first to born in the ENS, are transiently catecholaminergic (TC) and express the norepinephrine transporter (NET). Genetic NET deletion (NETKO) interferes with development of enteric serotonergic neurons...
- Non-linear Characterization of the Stretch Reflex Arc and its NeuromodulationAMAN BEHAL; Fiscal Year: 2011..3. To quantify the effect of the neurotransmitters serotonin and norepinephrine on the non-linear dynamics of the DRG AE motoneuron segment. 4...
- MULTIDIMENSIONAL HORMONAL ASSESSMENT OF PTSDSheila Wang; Fiscal Year: 1999..has found characteristic alterations in several major hormonal systems in combat-related PTSD, including norepinephrine, cortisol, and especially an unusual thyroid hormone profile characterized by marked elevations of both free ..
- Development of Pharmacotherapies for Nicotine AddictionFrank Carroll; Fiscal Year: 2009..These changes likely occur by its activity at the dopamine and norepinephrine transporters, DAT and NET, respectively...
- THE EFFECTS OF COCAINE ON FETAL OXYGENATIONJames Woods; Fiscal Year: 1993Cocaine produces increases in blood pressure and heart rate by interfering with the uptake and degradation of norepinephrine at adrenergic nerve terminals...
- Pupil Size and Circadian Salivary Variations in Autism Spectrum DisorderJOHN A COLOMBO; Fiscal Year: 2010..The aim of the current application is to explore non-invasive measures of both the hypothalamic and norepinephrine systems to determine their involvement in producing atypical autonomic responses in children with autism...
- RADIOLIGANDS FOR CENTRAL NORADRENERGIC UPTAKE SITESShanaz Tejani Butt; Fiscal Year: 1992..disorders or the mechanism(s) of action of psychotropic drugs has focused on brain monoamines, in particular norepinephrine and serotonin (5HT)...
- Radiation Combined Injury: Mechanisms and Therapeutic ApproachesPing Wang; Fiscal Year: 2009..Ghrelin inhibits the sympathetic nervous system, as evidenced by the reduction of norepinephrine (NE) release and inactivation of sympathostimulatory neurons in the brain in sepsis...
- Methamphetamine, Stress and SIV: Effects at Blood-Brain Barrier and Lymph NodesJohn P Capitanio; Fiscal Year: 2010..Meth is a sympathomimetic causing release of norepinephrine from peripheral nerves, and we have shown that norepinephrine promotes HIV and SIV replication...