midodrine

Summary

Summary: An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.

Top Publications

  1. ncbi Usefulness of midodrine in patients with severely symptomatic neurocardiogenic syncope: a randomized control study
    A Perez-Lugones
    The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cardiovasc Electrophysiol 12:935-8. 2001
  2. ncbi Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide
    P Angeli
    Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
    Hepatology 29:1690-7. 1999
  3. ncbi Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study
    Horacio Kaufmann
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 52:342-5. 2002
  4. ncbi Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension
    Steven H Platts
    Universities Space Research Association, Houston, TX, USA
    Aviat Space Environ Med 77:429-33. 2006
  5. ncbi Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
  6. ncbi Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, People s Republic of China
    Am J Cardiol 112:816-20. 2013
  7. ncbi Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride
    Jinyan Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    J Pediatr 163:1169-73.e2. 2013
  8. ncbi Midodrine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study
    Virendra Singh
    Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Hepatol 56:348-54. 2012
  9. ncbi Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Fengwen Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Am Coll Cardiol 60:315-20. 2012
  10. ncbi A case of neurally mediated syncope induced by laughter successfully treated with combination of propranolol and midodrine
    Makoto Amaki
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Int Heart J 48:123-7. 2007

Research Grants

  1. OTOLITH INFLUENCES ON SYMPATHETIC ACTIVITY
    Horacio Kaufmann; Fiscal Year: 2004
  2. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
  3. CIRRHOSIS AND ITS COMPLICATIONS
    Guadalupe Garcia Tsao; Fiscal Year: 2009
  4. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
  5. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
  6. Autonomic Nervous System in Chronic Fatigue Syndrome
    Italo Biaggioni; Fiscal Year: 2009
  7. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
  8. T Wave Alternans and Repolarization Abnormalities
    Daniel Bloomfield; Fiscal Year: 2003

Detail Information

Publications183 found, 100 shown here

  1. ncbi Usefulness of midodrine in patients with severely symptomatic neurocardiogenic syncope: a randomized control study
    A Perez-Lugones
    The Cleveland Clinic Foundation, Ohio 44195, USA
    J Cardiovasc Electrophysiol 12:935-8. 2001
    INTRODUCTION: The efficacy of midodrine for the management of patients with neurocardiogenic syncope was assessed prospectively in a randomized control study...
  2. ncbi Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide
    P Angeli
    Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy
    Hepatology 29:1690-7. 1999
    ..Five of them were treated with the oral administration of midodrine and the parenteral administration of octreotide...
  3. ncbi Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study
    Horacio Kaufmann
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 52:342-5. 2002
    ..We conducted a double-blind, randomized, crossover trial to investigate the efficacy of midodrine, a selective alpha-1 adrenergic agonist that decreases venous capacitance, in preventing neurally mediated ..
  4. ncbi Hemodynamic effects of midodrine after spaceflight in astronauts without orthostatic hypotension
    Steven H Platts
    Universities Space Research Association, Houston, TX, USA
    Aviat Space Environ Med 77:429-33. 2006
    ..The alpha-1 adrenergic agonist, midodrine, may be an effective countermeasure...
  5. ncbi Efficacy of midodrine vs placebo in neurogenic orthostatic hypotension. A randomized, double-blind multicenter study. Midodrine Study Group
    P A Low
    Department of Neurology, Mayo Clinic, Rochester, Minn 55905, USA
    JAMA 277:1046-51. 1997
    To evaluate the efficacy of a 10-mg dose of midodrine 3 times per day in improving blood pressure (BP) and ameliorating symptoms of orthostatic hypotension in patients with neurogenic orthostatic hypotension...
  6. ncbi Flow-mediated vasodilation as a predictor of therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Ying Liao
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, People s Republic of China
    Am J Cardiol 112:816-20. 2013
    ..was designed to explore the value of flow-mediated vasodilation (FMD) as a predictor of therapeutic response to midodrine hydrochloride (MD) in children with postural orthostatic tachycardia syndrome (POTS)...
  7. ncbi Postural orthostatic tachycardia syndrome with increased erythrocytic hydrogen sulfide and response to midodrine hydrochloride
    Jinyan Yang
    Department of Pediatrics, Peking University First Hospital, Beijing, PR China
    J Pediatr 163:1169-73.e2. 2013
    To evaluate the use of erythrocytic hydrogen sulfide (H2S) in predicting the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS).
  8. ncbi Midodrine in patients with cirrhosis and refractory or recurrent ascites: a randomized pilot study
    Virendra Singh
    Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    J Hepatol 56:348-54. 2012
    ..The aim of this study was to evaluate the effects of long term administration of midodrine on systemic hemodynamics, renal function, and control of ascites in patients with cirrhosis and refractory or ..
  9. ncbi Midregional pro-adrenomedullin as a predictor for therapeutic response to midodrine hydrochloride in children with postural orthostatic tachycardia syndrome
    Fengwen Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    J Am Coll Cardiol 60:315-20. 2012
    ..designed to explore the predictive value of the midregional fragment of pro-adrenomedullin (MR-proADM) in assessing the therapeutic efficacy of midodrine hydrochloride for children with postural orthostatic tachycardia syndrome (POTS).
  10. ncbi A case of neurally mediated syncope induced by laughter successfully treated with combination of propranolol and midodrine
    Makoto Amaki
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Int Heart J 48:123-7. 2007
    ..His daughter also had NMS and her syncope was treated with propranolol. Propranolol and midodrine hydrochloride, an alpha(1)-adrenergic stimulant, were effective at preventing his laughter-induced syncope...
  11. ncbi Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review
    Suma Prakash
    London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada, N6A 5A5
    Nephrol Dial Transplant 19:2553-8. 2004
    Dialysis-induced hypotension is an important complication of haemodialysis. Midodrine is an oral alpha-1 agonist that has been used in several small studies to prevent intradialytic hypotension (IDH).
  12. ncbi Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome
    Li Chen
    Department of Pediatrics, Peking University First Hospital, Beijing, China
    Circ J 75:927-31. 2011
    The study was carried out to examine the effect of selective α1 adrenoceptor agonist midodrine hydrochloride vs. β-adrenergic blockade metoprolol in the treatment of children with postural orthostatic tachycardia syndrome (POTS).
  13. ncbi Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives
    Masahiro Tsuda
    Department of Pharmacy, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    J Pharmacol Exp Ther 318:455-60. 2006
    b>Midodrine is an oral drug for orthostatic hypotension...
  14. ncbi Outcomes in adolescents with postural orthostatic tachycardia syndrome treated with midodrine and beta-blockers
    Cindy C Lai
    Department of Pharmacy, Mayop Clinic, Rochester, Minnesota 55905, USA
    Pacing Clin Electrophysiol 32:234-8. 2009
    ..The effects of medical therapy have not been well studied in this patient population. This study assessed the relative efficacy and impact of drug therapy on the functioning and quality of life in adolescents with POTS...
  15. ncbi Octreotide/Midodrine therapy significantly improves renal function and 30-day survival in patients with type 1 hepatorenal syndrome
    Eric Esrailian
    Division of Digestive Diseases, David Geffen School of Medicine at UCLA, USA
    Dig Dis Sci 52:742-8. 2007
    ..We compared the survival of HRS patients who received octreotide and midodrine treatment at Rancho Los Amigos Medical Center with a concurrent untreated control group of HRS patients who did ..
  16. ncbi The effects of chronic treatment with octreotide versus octreotide plus midodrine on systemic hemodynamics and renal hemodynamics and function in nonazotemic cirrhotic patients with ascites
    Georgios Kalambokis
    Department of Internal Medicine, Medical School, Ioannina, Greece
    Am J Gastroenterol 100:879-85. 2005
    The adrenergic agonist midodrine improved circulatory and renal dysfunction when acutely administered in nonazotemic cirrhotic patients with ascites while its combination with octreotide has recently been proposed as an effective ..
  17. ncbi Effects of a 7-day treatment with midodrine in non-azotemic cirrhotic patients with and without ascites
    Georgios Kalambokis
    1st Division of Internal Medicine and Hepatogastroenterology Unit, University Hospital, Ioannina, Greece
    J Hepatol 46:213-21. 2007
    ..This study evaluated the effects of a 7-day treatment with the alpha1-adrenergic agonist midodrine in non-azotemic cirrhotic patients with and without ascites.
  18. ncbi Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome
    Florence Wong
    Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada
    Hepatology 40:55-64. 2004
    ..type 1 HRS in ascitic cirrhotic patients, following improvement in systemic hemodynamics with a combination of midodrine, octreotide, and albumin (medical treatment)...
  19. ncbi Treatment of vasodepressor carotid sinus syndrome with midodrine: a randomized, controlled pilot study
    Allan Moore
    Clinical Age Assessment Unit, Mid Western Regional Hospital, Dooradoyle, Limerick, Ireland
    J Am Geriatr Soc 53:114-8. 2005
    To evaluate the efficacy of treatment of the vasodepressor form of carotid sinus hypersensitivity (carotid sinus syndrome (CSS)) with midodrine.
  20. ncbi Midodrine in the prevention of hepatorenal syndrome type 2 recurrence: a case-control study
    C Alessandria
    Division of Gastroenterology and Hepatology, San Giovanni Battista Hospital, Turin, Italy
    Dig Liver Dis 41:298-302. 2009
    ..b>Midodrine, an oral adrenergic vasoconstrictor, has been suggested to be an effective therapy in hepatorenal syndrome.
  21. ncbi Combination treatment with octreotide, midodrine, and albumin improves survival in patients with type 1 and type 2 hepatorenal syndrome
    Catherine Skagen
    Section of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    J Clin Gastroenterol 43:680-5. 2009
    Few therapeutic modalities exist for the treatment of hepatorenal syndrome (HRS). The combination of octreotide, midodrine, and albumin has shown possible benefit in small preliminary studies in improving renal function and short-term ..
  22. ncbi Midodrine and octreotide in treatment of cirrhosis-related hemodynamic complications
    Rakhi Karwa
    Harrison School of Pharmacy, Auburn University, AL, USA
    Ann Pharmacother 43:692-9. 2009
    To review studies evaluating the use of midodrine and octreotide in hemodynamic complications of cirrhosis, including ascites and hepatorenal syndrome.
  23. ncbi The effect of 1 month of therapy with midodrine, octreotide-LAR and albumin in refractory ascites: a pilot study
    Puneeta Tandon
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Liver Int 29:169-74. 2009
    ..We hypothesized that a combination of midodrine, octreotide long-acting release (LAR) and albumin would result in increased natriuresis, better control of ..
  24. ncbi Midodrine for the management of orthostatic hypotension in patients with spinal cord injury: A case report
    J Mukand
    Southern New England Rehabilitation Center, Department of Orthopedics and Rehabilitation, Brown University, Providence, RI, USA
    Arch Phys Med Rehabil 82:694-6. 2001
    ..Severe orthostatic hypotension in the upright position complicated the patient's rehabilitation program. Midodrine was prescribed, and other medications with possible adverse effects were adjusted...
  25. ncbi Treatment of Severe Intradialytic Hypotension With the Addition of High Dialysate Calcium Concentration to Midodrine and/or Cool Dialysate
    R Alappan
    Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA
    Am J Kidney Dis 37:294-9. 2001
    ..Cool dialysate (34.5 degrees C to 35.5 degrees C) and midodrine may provide hemodynamic stability through an increase in peripheral vascular resistance, whereas high dialysate ..
  26. ncbi The efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope
    Zhang Qingyou
    Department of Pediatrics and Institute of Cardiovascular Research, Peking University First Hospital and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, People s Republic of China
    J Pediatr 149:777-80. 2006
    To determine whether midodrine hydrochloride therapy can prevent vasovagal syncope (VVS) in pediatric patients.
  27. ncbi Successful treatment of chronic fatigue syndrome with midodrine: a pilot study
    J E Naschitz
    Clin Exp Rheumatol 21:416-7. 2003
  28. ncbi Why is orthostatic tolerance lower in women than in men? Renal and cardiovascular responses to simulated microgravity and the role of midodrine
    S Marlene Grenon
    Division of Endocrinology, Hypertension and Diabetes, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Investig Med 54:180-90. 2006
    ..We assessed the renal, cardioendocrine, and cardiovascular responses of women and men to simulated microgravity to examine the impact of gender on OI...
  29. ncbi Midodrine: a selective alpha-adrenergic agonist for orthostatic hypotension and dialysis hypotension
    D N Cruz
    Section of Nephrology, Department of Medicine, Yale University School of Medicine, 333 Cedar Street LMP 2071, New Haven, CT 06520 8029, USA
    Expert Opin Pharmacother 1:835-40. 2000
    b>Midodrine is an oral agent which acts as a selective peripherally-acting alpha-receptor agonist...
  30. ncbi Double-blinded, placebo-controlled trial of midodrine for exercise performance enhancement in tetraplegia: a pilot study
    Edward C Nieshoff
    Rehabilitation Institute of Michigan, Detroit, Michigan, USA
    J Spinal Cord Med 27:219-25. 2004
    ..to engage in physical activity improves with elevation of blood pressure through pharmacologic treatment: Midodrine, an oral alpha-sympathomimetic agent, has been shown to be safe and efficacious for this purpose...
  31. ncbi Comment on "Midodrine hydrochloride and L-threo-3,4-dihydroxy-phenylserine preserve cerebral blood flow in hemodialysis patients with orthostatic hypotension" by Fujisaki et al
    Vijay Sharma
    Ther Apher Dial 11:407-8. 2007
  32. ncbi Effect of mineralocorticoids on interdialytic weight gain in hemodialysis patients with perdialytic hypotension
    Lucile Mercadal
    Hopital Pitie Salpetriere, 83 bd de l hopital, Paris, France
    Hemodial Int 9:338-40. 2005
    ..We report 2 patients who suffered from chronic severe perdialytic hypotension resistant to midodrine and who were treated in a long-term period with fludrocortisone...
  33. ncbi Beneficial haemodynamic and renal sodium handling effects of combined midodrine and octreotide treatment in a cirrhotic patient with large hepatic hydrothorax and mild ascites
    Georgios Kalambokis
    Nephrol Dial Transplant 20:2583. 2005
  34. ncbi Midodrine: insidious development of urologic adverse effects in patients with spinal cord injury: a report of 2 cases
    Subramanian Vaidyanathan
    Regional Spinal Injuries Centre, District General Hospital, Southport, United Kingdom
    Adv Ther 24:712-20. 2007
    b>Midodrine, a prodrug, is converted after oral administration into its active drug, desglymidodrine, which acts as an alpha(1)-adrenoceptor stimulant...
  35. ncbi Effects of midodrine on exercise-induced hypotension and blood pressure recovery in autonomic failure
    William G Schrage
    Department of Anesthesia Research, Joseph 4 184W, Mayo Clinic, Rochester, MN 55905, USA
    J Appl Physiol (1985) 97:1978-84. 2004
    We tested the hypothesis that the oral alpha1-adrenergic agonist, midodrine, would limit the fall in arterial pressure observed during exercise in patients with pure autonomic failure (PAF)...
  36. ncbi Prolonged supine hypertension due to midodrine use in an orthostatic hypotensive child
    S Olgar
    Department of Pediatric Cardiology, Istanbul University, Istanbul Faculty of Medicine, 34390, Capa, Istanbul, Turkey
    Pediatr Cardiol 28:309-10. 2007
    b>Midodrine hydrochloride is a potent peripherally-acting alpha1 agonist that is well absorbed and rapidly metabolized to its active metabolite...
  37. ncbi Midodrine prevents orthostatic intolerance associated with simulated spaceflight
    C D Ramsdell
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Appl Physiol 90:2245-8. 2001
    ..study (an analog of weightlessness) using normal human volunteers and administered the alpha(1)-agonist drug midodrine at the end of the bed-rest period...
  38. ncbi Orthostatic hypotension in the elderly: diagnosis and treatment
    Vishal Gupta
    Beth Israel Deaconess Medical Center, Hebrew SeniorLife, and Harvard Medical School, Boston, Mass 02131, USA
    Am J Med 120:841-7. 2007
    ..remains persistently symptomatic, various pharmacotherapeutic agents can be added, including fludrocortisone, midodrine, and nonsteroidal anti-inflammatory drugs...
  39. ncbi [Successful midodrin treatment for vasovagal syncopes accompanied by asystole]
    A V Pevzner
    Klin Med (Mosk) 82:53-6. 2004
    ..On the basis of the pathogenesis of WS, the use of alpha-adrenomimetic midodrine is justifiable...
  40. ncbi Blood pressure changes during sexual stimulation, ejaculation and midodrine treatment in men with spinal cord injury
    Frédérique J Courtois
    Department of Sexology, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    BJU Int 101:331-7. 2008
    To explore the effectiveness of various sources of self-stimulation, including oral midodrine, in triggering ejaculation in men with spinal cord injury (SCI), and to document the systematic variations in blood pressure at ejaculation and ..
  41. pmc Stress induced hypotension in pure autonomic failure
    R D Thijs
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Neurol Neurosurg Psychiatry 77:552-3. 2006
    ..During a tilt table test, hyperventilation was shown to cause a significant fall of blood pressure. This suggests that emotional stress can induce hypotension, probably through hyperventilation, in subjects with autonomic failure...
  42. ncbi [Sjögren's syndrome with autonomic failure and epilepsy]
    H Attout
    Service de Medecine Interne, CHU Pellegrin, 33000 Bordeaux, France
    Rev Med Interne 26:141-4. 2005
    ..Neurological complications may affect the peripheral nervous system and to lesser extent the central nervous system. Autonomic system nervous dysfunction and epilepsy have been rarely reported...
  43. ncbi Midodrine improves ejaculation in spinal cord injured men
    J M Soler
    Laboratoire d urodynamique et de sexologie, Centre Bouffard Vercelli, Cap Peyrefite, Cerbère, France
    J Urol 178:2082-6. 2007
    We evaluated the effect of the alpha1-adrenergic agonist midodrine given orally for anejaculation in spinal cord injured men.
  44. doi Vasoconstrictor therapy for patients with cirrhosis with ascites but without hepatorenal syndrome
    Georgios N Kalambokis
    Hepatology 48:686. 2008
  45. ncbi Adverse drug reactions related to drugs used in orthostatic hypotension: a prospective and systematic pharmacovigilance study in France
    Atul Pathak
    Service de Pharmacologie Clinique, centre Midi Pyrénées de pharmacovigilance, de Pharmacoepidemiologie et d Informations sur le Medicament, Hopitaux de Toulouse, 37 Allees Jules Guesde, 31073, Toulouse Cedex 7, France
    Eur J Clin Pharmacol 61:471-4. 2005
    ..The aim of the present study was to investigate and characterise adverse drug reactions (ADRs) to drugs used in France for orthostatic hypotension (OH)...
  46. ncbi Consequences of cardiovascular adaptation to spaceflight: implications for the use of pharmacological countermeasures
    Victor A Convertino
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6513, USA
    Gravit Space Biol Bull 18:59-69. 2005
    ..g., fludrocortisone, electrolyte-containing beverages) and reserve for vasoconstriction (e.g., midodrine, vasopressin)...
  47. ncbi Chiral investigation of midodrine, a long-acting alpha-adrenergic stimulating agent
    M G Quaglia
    Dipartimento di Studi Farmaceutici, Universita La Sapienza, Rome, Italy
    Chirality 16:356-62. 2004
    b>Midodrine hydrochloride is a peripheral alpha(1)-adrenoreceptor agonist that induces venous and arterial vasoconstriction...
  48. ncbi N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine
    Robert J Altenbach
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA
    J Med Chem 45:4395-7. 2002
    ..4) and alpha(1D) (rat aorta, pA(2) = 6.2) antagonism. An in vivo dog model showed 1 to be more selective for the urethra over the vasculature than A-61603 (2), ST-1059 (3, the active metabolite of midodrine), and phenylpropanolamine (4).
  49. ncbi Pandysautonomia associated with impaired ganglionic neurotransmission and circulating antibody to the neuronal nicotinic receptor
    David S Goldstein
    Building 10, Room 6N252, Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Clin Auton Res 12:281-5. 2002
    ..The findings in this case support the concept that circulating antibodies to this receptor can interfere with ganglionic neurotransmission and produce autoimmune autonomic neuropathy...
  50. ncbi [Effects of midodrine on symptomatic hypotension during hemodialysis]
    Alejandro Cotera
    Unidad de Atención Nefrológica Continua, Seccion de Nefrologia, Departamento de Medicina, Hospital Clinico Universidad de Chile
    Rev Med Chil 130:1009-13. 2002
    ..Hypotension occurs in 20% of hemodialysis procedures...
  51. ncbi Midodrine, an alternative to intravenous vasopressor therapy after spinal surgery
    B O'DONNELL
    Eur J Anaesthesiol 19:841-2. 2002
  52. ncbi Recurrent syncope in a 31-year-old army staff sergeant
    Thomas M Wiley
    Department of Medicine and Cardiology Service, Walter Reed Army Medical Center, Washington, DC, USA
    Mil Med 167:263-5. 2002
  53. ncbi Determination of midodrine in human plasma by high-performance liquid chromatography with fluorescence detection
    Hideyuki Yoshida
    Faculty of Pharmaceutical Sciences, Fukuoka University, Nanakuma, Johnan, Fukuoka 814 0180, Japan
    Anal Sci 19:317-9. 2003
    ..and sensitive fluorometric high-performance liquid chromatographic method was developed for the determination of midodrine in human plasma...
  54. pmc Atrial septal aneurysm with right-to-left interatrial shunting
    Mala Chidambaram
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
    Tex Heart Inst J 30:68-70. 2003
    ..In this patient, we used midodrine, an oral alpha-1 agonist, to increase systemic arterial pressure, decrease the severity of the shunt, and treat ..
  55. ncbi [Treatment of ejaculation disorders]
    J M Soler
    Ann Readapt Med Phys 48:41-2. 2005
  56. ncbi Hemodynamics in patients with intradialytic hypotension treated with cool dialysate or midodrine
    Heidi Hoeben
    Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520 8029, USA
    Am J Kidney Dis 39:102-7. 2002
    Cool dialysate and midodrine have been used successfully to treat intradialytic hypotension (IDH) in the end-stage renal disease population...
  57. ncbi [Vasoconstrictors in the treatment of hepatorenal syndrome]
    R Ortega
    Unitat d Hepatologia, Institut de Malalties Digestives, Hospital Clinic, Barcelona
    Nefrologia 22:56-61. 2002
  58. ncbi Randomized double-blind placebo-controlled multicenter evaluation of efficacy and dose finding of midodrine hydrochloride in women with mild to moderate stress urinary incontinence: a phase II study
    E H Weil
    University Hospital Maastricht, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 9:145-50. 1998
    b>Midodrine is a potent and selective alpha1-receptor agonist and its potential to increase urethral closure pressure could be useful in the treatment of female stress incontinence...
  59. ncbi Randomized clinical trials of neurally mediated syncope
    Michele Brignole
    Arrhythmologic Centre, Department of Cardiology, Ospedali del Tigullio, Lavagna, Italy
    J Cardiovasc Electrophysiol 14:S64-9. 2003
    ..disopyramide, scopolamine, clonidine, theophylline, fludrocortisone, ephedrine, dihydroergotamine, etilefrine, midodrine, clonidine, serotonin reuptake inhibitors, enalapril)...
  60. ncbi Vasoconstrictor therapy for hepatorenal syndrome in liver cirrhosis
    L E Schmidt
    Department of Hepatology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Curr Pharm Des 12:4637-47. 2006
    ..Several vasoconstrictors including the alpha-adrenergic agonists, midodrine and noradrenalin, and the vasopressor analogues, ornipressin and terlipressin, have all been associated with a ..
  61. ncbi Characterisation of the functional alpha-adrenoceptor subtype in the isolated female pig urethra
    P Alberts
    Department of Pharmacology, Pharmacia and Upjohn, Uppsala, Sweden
    Eur J Pharmacol 371:31-8. 1999
    ..68), oxymetazoline (0.60), dopamine (0.50), clonidine (0.43), midodrine (0.32), ephedrine (0.30), 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine (UK 14,304) (0...
  62. ncbi [Orthostatic hypotension and supine hypertension in pure autonomic failure]
    Michelangelo Sartori
    Clinica Medica 4, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Padova
    Ital Heart J Suppl 5:879-83. 2004
    ..Primary autonomic failure exhibits, often, supine hypertension, that can be worsened by pressor agents, such as midodrine, used to prevent syncope episodes...
  63. ncbi Contrasting actions of pressor agents in severe autonomic failure
    J Jordan
    Clinical Research Center, Franz Volhard Clinic, Berlin, Germany
    Am J Med 105:116-24. 1998
    ..Orthostatic hypotension is the most disabling symptom of autonomic failure. The choice of a pressor agent is largely empiric, and it would be of great value to define predictors of a response...
  64. ncbi Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management
    J M Senard
    Laboratory of Medical and Clinical Pharmacology, INSERM U317, Faculty of Medicine, Paul Sabatier University, Toulouse, France
    Drugs Aging 18:495-505. 2001
    ..Among the available drugs, alpha1-adrenergic agonists (mainly midodrine) or plasma volume expanders (mainly fludrocortisone) are the most frequently used...
  65. ncbi Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Arch Neurol 65:213-7. 2008
    ..Symptomatic and immunomodulatory therapy has provided limited clinical benefit in small uncontrolled studies...
  66. ncbi Ascites and spontaneous bacterial peritonitis: an Asian perspective
    Jung Min Lee
    Department of Internal Medicine, Brain Korea 21 Project for Medical Science, Seoul, South Korea
    J Gastroenterol Hepatol 24:1494-503. 2009
    ..medical therapy have been made with satavaptan, a V2 receptor antagonist, vasoconstrictors, such as clonidine, midodrine, or terlipressin, and other categories of drugs, including docarpamine and Chinese herbs...
  67. ncbi Strategy for the management of vasovagal syncope
    Daniel M Bloomfield
    Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Drugs Aging 19:179-202. 2002
    ..Data from randomised placebo-controlled studies support the efficacy of beta-blockers, midodrine, serotonin reuptake inhibitors and ACE inhibitors...
  68. ncbi Drug treatment of orthostatic hypotension because of autonomic failure or neurocardiogenic syncope
    Maxime Lamarre-Cliche
    Hôpital Européen Georges Pompidou Centre d Investigations Cliniques, Paris, France
    Am J Cardiovasc Drugs 2:23-35. 2002
    ..In patients with orthostatic hypotension because of autonomic failure, alpha-adrenoceptor agonists, and midodrine in particular, have been shown to increase standing blood pressure and decrease orthostatic symptoms...
  69. ncbi Treatment of vasovagal syncope: an update
    Luciana Armaganijan
    Arrhythmia and Pacing Service, McMaster University HHSC PHRI, 237 Barton Street East, David Bradley CVSRI, Room C3 120, Hamilton, ON, Canada, L8L 2X2
    Curr Treat Options Cardiovasc Med 12:472-88. 2010
    ..b>Midodrine is the only drug proven to prevent VVS recurrence; however, no consistent prescription guidelines exist...
  70. ncbi The use of vasoconstrictors in patients with cirrhosis: type 1 HRS and beyond
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, Clichy, France
    Hepatology 43:385-94. 2006
    ..and systemic) vasoconstrictors such as terlipressin (a vasopressin analog) or alpha-1-adrenoceptor agonists (midodrine or noradrenaline) may improve renal function in patients with type 1 HRS...
  71. ncbi [Pharmacotherapy of stress incontinence]
    W H Jost
    Fachbereich Neurologie und Klinische Neurophysiologie, Deutsche Klinik fur Diagnostik, Wiesbaden
    Dtsch Med Wochenschr 130:2337-42. 2005
    ..a-Adrenergics, such as phenylpropanolamine and midodrine, and b-adrenergics, such as clenbuterol, are also used in "off-label" therapy...
  72. ncbi [Cardiovascular disorders in Parkinson's disease]
    R Suárez-Moro
    Hospital Valle del Nalon, Langreo, Asturias, Espana
    Rev Neurol 50:S59-63. 2010
    ....
  73. ncbi Octreotide for orthostatic hypotension
    M Lamarre-Cliche
    Clinical Pharmacology, Centre Hospitalier de l Universite de Montreal CHUM, Canada
    Can J Clin Pharmacol 6:213-5. 1999
    ..Because the disease was progressively refractory to fludrocortisone and midodrine, octreotide was introduced subcutaneously (25 micrograms before meals)...
  74. ncbi Ergotamine use in severe diabetic autonomic neuropathy
    V Toh
    Oxford Centre of Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, UK
    Diabet Med 23:574-6. 2006
    ..When it does occur, it can prove debilitating and difficult to treat. We report here the therapeutic challenges encountered in managing a patient with severe postural hypotension secondary to diabetes-related autonomic neuropathy...
  75. ncbi [Arterial hypertension with orthostatic hypotension]
    B Krahulec
    II interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenska republika
    Vnitr Lek 56:951-4. 2010
    ..AH with OH can be treated with short-acting antihypertensive drugs, eventually with transdermal nitroglycerin. OH can be treated with clonidine, midodrine, fludrocortisone or beta1-blocker.
  76. ncbi L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy
    Christopher H Gibbons
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 65:1104-6. 2005
    ..She presented with severe orthostatic intolerance refractory to treatment with midodrine, fludrocortisone, erythropoietin, vasopressin, salt, and fluid loading...
  77. ncbi Current management of syncope : focus on drug therapy
    Deviprasad Venugopal
    Department of Medicine, University of Minnesota Medical Center, Minneapolis, Minnesota, USA
    Am J Cardiovasc Drugs 7:399-411. 2007
    ..Various drugs may play a role as second-line of treatment. However, apart from midodrine, randomized studies of drug therapy are largely lacking, and most agents have not proved to be predictably ..
  78. ncbi Acute renal failure in patients with cirrhosis: perspectives in the age of MELD
    Richard Moreau
    Laboratoire d Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U 481, Clichy, France
    Hepatology 37:233-43. 2003
    ..Systemic vasoconstrictor therapy (with terlipressin, noradrenaline, or midodrine [combined with octreotide]) may improve renal function in patients with type 1 HRS waiting for liver ..
  79. ncbi Hepatorenal syndrome: current management
    Florence Wong
    Toronto General Hospital, University of Toronto, Ninth Floor, North Wing, Room 983, 200 Elizabeth Street, Toronto M5G 2C4, Ontario, Canada
    Curr Gastroenterol Rep 10:22-9. 2008
    ..Vasoconstrictors (eg, midodrine, terlipressin, or norepinephrine) together with albumin can improve the effective arterial blood volume with ..
  80. ncbi Management of hepatorenal syndrome
    P A McCormick
    National Liver Transplant Unit, St Vincent s University Hospital, Elm Park, Donnybrook, Dublin 4, Ireland
    Pharmacol Ther 119:1-6. 2008
    ..Agents currently used include the vasopressin analogues terlipressin and the alpha1-adrenoceptor agonist midodrine. The somatostatin analogue octreotide has been used in combination therapy but is ineffective as monotherapy...
  81. ncbi Diagnosis and treatment of acute renal failure in patients with cirrhosis
    Richard Moreau
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, and Service d Hépatologie, Hopital Beaujon, 92118 Clichy, France
    Best Pract Res Clin Gastroenterol 21:111-23. 2007
    ..terlipressin (combined with intravenous human albumin), noradrenaline (combined with albumin and furosemide) or midodrine (combined with octreotide and albumin) may improve renal function in patients with type 1 HRS waiting for liver ..
  82. ncbi Isolated sympathetic failure with autoimmune autonomic ganglionopathy
    Philip R Fischer
    Division of General Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Pediatr Neurol 43:287-90. 2010
    ..with aggressive symptomatic interventions (permanent pacemaker implantation and treatment with pyridostigmine, midodrine, and modafinil)...
  83. ncbi EFNS guidelines on the diagnosis and management of orthostatic hypotension
    H Lahrmann
    Neurological Department and L Boltzmann Institute for Neurooncology, Kaiser Franz Josef Hospital, Vienna, Austria
    Eur J Neurol 13:930-6. 2006
    ..Fludrocortisone is a valuable starter drug. Second line drugs include sympathomimetics, such as midodrine, ephedrine, or dihydroxyphenylserine. Supine hypertension has to be considered.
  84. ncbi [Modern management of vasovagal syncope]
    P Djiane
    Departement de Cardiologie, CHU Marseille, Hopital de la Timone, 13385 Marseille Cedex
    Arch Mal Coeur Vaiss 99:49-52. 2006
    ..In these severe and disabling forms, the doctor has to make a choice between empirical prescibing, preferably midodrine, and a more rational strategy guided by an intercritical recording obtained with an implanted ECG monitor which ..
  85. pmc Management and therapy of vasovagal syncope: A review
    Muhammet Ali Aydin
    Muhammet Ali Aydin, Tushar V Salukhe, Iris Wilke, Stephan Willems, Department of Electrophysiology, University Heart Center Hamburg, Martinistrase 52, Hamburg 20246, Germany
    World J Cardiol 2:308-15. 2010
    ..syncope and discusses the non-pharmacological and pharmacological treatment options, especially the use of midodrine and selective serotonin reuptake inhibitors...
  86. ncbi Dysautonomia and neurocardiogenic syncope
    K A McLeod
    Department of Cardiology, Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow, UK
    Curr Opin Cardiol 16:92-6. 2001
    ..If symptoms are troublesome, Fludrocortisone and B-blockers remain the favored drugs. The efficacy of Midodrine and Serotonin Uptake Inhibitors is currently under review...
  87. ncbi Neurocardiogenic syncope in children : current concepts in diagnosis and management
    Martial Massin
    Division of Pediatric Cardiology, University of Liège at Regional Hospital Centre La Citadelle, Liege, Belgium
    Paediatr Drugs 5:327-34. 2003
    ..time, beta-adrenergic receptor blockers, fludrocortisone, and also specific serotonin reuptake inhibitors and midodrine, appear to be favored treatment options...
  88. ncbi Oral-based controlled release formulations using poly(acrylic acid) microgels
    Marie Wahlgren
    Division of Food Technology, Department of Food Engineering, Lund University, Lund, Sweden
    Drug Dev Ind Pharm 35:922-9. 2009
    ..To investigate the release of hydrophobic and hydrophilic substances from tablets containing Pemulen and Carbopol as excipients...
  89. ncbi Dialysis induced hypotension--a serious clinical problem in renal replacement therapy
    Władysław Sułowicz
    Department of Nephrology, Jagiellonian University, Krakow, Poland
    Med Pregl 60:14-20. 2007
    ..g. midodrine, caffeine, vasopressin analogues)...
  90. ncbi Neurological complications of chronic kidney disease
    Arun V Krishnan
    Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    Nat Rev Neurol 5:542-51. 2009
    ..For patients with autonomic neuropathy, specific treatments, including sildenafil for impotence and midodrine for intradialytic hypotension, are effective and well tolerated...
  91. ncbi Chronic hypotension in the dialysis patient
    Aleix Cases
    Division of Nephrology, Clinic and Provincial Hospital, IDIBAPS, University of Barcelona, Catalonia, Spain
    J Nephrol 15:331-5. 2002
    ..The treatment of this complication is not well defined and the measures recommended (contention in the lower limbs or the sympathomimetic agent midodrine) are of limited benefit.
  92. ncbi Arterial hypertension, a tricky side of Parkinson's disease: physiopathology and therapeutic features
    Alberto Mazza
    Department of Internal Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy
    Neurol Sci 34:621-7. 2013
    ..e., fludrocortisone acetate, midodrine) or PD itself (i.e., monoamine oxidase inhibitors, dopamine D2-receptor antagonists)...
  93. ncbi Calf venous compliance in multiple system atrophy
    A Lipp
    Autonomic Reflex Laboratory, Department of Neurology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 293:H260-5. 2007
    ..The response to the directly acting alpha-adrenergic stimulation (10 mg midodrine) on calf venous compliance was additionally evaluated...
  94. ncbi [Evaluation of the management of erectile and ejaculatory dysfunction in a series of 90 patients with spinal cord injuries]
    N Hadiji
    Centre Bouffard vercelli Cap Peyrefite, 66290 Cerbère, France Electronic address
    Prog Urol 23:1489-93. 2013
    ..To evaluate the erectile dysfunction and ejaculatory on patients injured in conus medullaris (CMI) and the efficacy of treatment...
  95. ncbi [Therapies for postural tachycardia syndrome in children]
    Feng Wen Zhang
    Department of Pediatrics, Peking University First Hospital, Beijing 100034, China
    Zhonghua Er Ke Za Zhi 49:428-32. 2011
    ..compare the short-term and long-term effects of oral rehydration salts, oral rehydration salts plus metoprolol or oral rehydration salts plus midodrine hydrochloride on the treatment of postural tachycardia syndrome (POTS) in children.
  96. ncbi Severe transient hypertension after greater palatine foramen block in a patient taking midodrine
    Mark D Rizzi
    Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Otolaryngol 31:67-9. 2010
    ..occurring within 2 minutes of injection of 1% lidocaine with 1:100,000 U of epinephrine in a patient taking midodrine for orthostatic hypotension...
  97. ncbi [Efficacy of midodrine hydrochloride in the treatment of children with vasovagal syncope]
    Xiao Yan Liu
    Department of Cardiovascular Pediatrics, Second Xiangya Hospital, Institute of Pediatrics, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 89:1951-4. 2009
    To explore the efficacy of midodrine hydrochloride in the treatment of vasovagal syncope (VVS) in children.
  98. ncbi Assessment of therapeutic biomarkers in the treatment of children with postural tachycardia syndrome and vasovagal syncope
    Jing Lin
    Department of Pediatrics Peking University First Hospital, Beijing, China
    Cardiol Young 24:792-6. 2014
    ..The supplementation with water, or salt, or midodrine, or β-blocker was applied to children with postural tachycardia syndrome or vasovagal syncope...
  99. pmc The combination of octreotide and midodrine is not superior to albumin in preventing recurrence of ascites after large-volume paracentesis
    Khurram Bari
    Digestive Diseases, Yale University School of Medicine, New Haven, CT 06516, USA
    Clin Gastroenterol Hepatol 10:1169-75. 2012
    ..Vasoconstrictors could be used instead of albumin and, with longer use, prevent PCD and delay ascites recurrence...
  100. ncbi Refractory hypotension after bilateral nephrectomies in a Denys-Drash patient with phenylketonuria
    Amanda B Hassinger
    Department of Pediatrics, Division of Critical Care Medicine, Women and Children s Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222, USA
    Pediatr Nephrol 28:345-8. 2013
    ....
  101. ncbi Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia
    Jill M Wecht
    James J Peters Veterans Administration Medical Center, Bronx, NY, USA
    Arch Phys Med Rehabil 91:1429-35. 2010
    To determine the mean arterial pressure (MAP) and middle cerebral artery mean blood flow velocity (MFV) responses to 5 and 10mg midodrine during head-up tilt (HUT) in persons with tetraplegia.

Research Grants8

  1. OTOLITH INFLUENCES ON SYMPATHETIC ACTIVITY
    Horacio Kaufmann; Fiscal Year: 2004
    ..abstract_text> ..
  2. Circulatory Dysfunction in Chronic Fatigue Syndrome
    Julian Stewart; Fiscal Year: 2004
    ..CFS patients will be treated with midodrine or placebo in a cross-over study...
  3. CIRRHOSIS AND ITS COMPLICATIONS
    Guadalupe Garcia Tsao; Fiscal Year: 2009
    ..Garcia-Tsao has now received funding to evaluate the effect of a combination of vasoconstrictors ooctreotide+midodrine) as alternative to albumin after large-volume paracentesis...
  4. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  5. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  6. Autonomic Nervous System in Chronic Fatigue Syndrome
    Italo Biaggioni; Fiscal Year: 2009
    ....
  7. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..
  8. T Wave Alternans and Repolarization Abnormalities
    Daniel Bloomfield; Fiscal Year: 2003
    ....