ethanolamines

Summary

Summary: AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.

Top Publications

  1. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
  2. ncbi Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD
    Ronald Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    Thorax 65:473-9. 2010
  3. ncbi The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    Jesse Lo Verme
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    Mol Pharmacol 67:15-9. 2005
  4. pmc Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania
    Oliver J Sabot
    Malaria Control Team, Clinton Foundation HIV AIDS Initiative, Boston, Massachusetts, USA
    PLoS ONE 4:e6857. 2009
  5. pmc Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial
    Quique Bassat
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 4:e7871. 2009
  6. ncbi Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Pharmacol Exp Ther 326:12-23. 2008
  7. ncbi Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial
    Jacek Skarbinski
    Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Am J Trop Med Hyg 80:919-26. 2009
  8. ncbi Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children
    Emmanuel Arinaitwe
    Makerere University University of California San Francisco Research Collaboration, University of California, San Francisco 94143, USA
    Clin Infect Dis 49:1629-37. 2009
  9. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
  10. pmc In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1
    Leah Mwai
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, Kilifi, Kenya
    Antimicrob Agents Chemother 53:5069-73. 2009

Research Grants

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  2. HEAD GROUP INTERACTIONS IN MEMBRANES AND MICELLES
    KENNETH DILL; Fiscal Year: 1991
  3. Causal and Nonlinear Models of Cancer Risk Among Autoworkers
    Ellen Eisen; Fiscal Year: 2009
  4. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
  5. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
  6. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
  7. CYTOSTATIC ROLE OF THE ARGININE-NITRIC OXIDE PATHWAY
    Louis Ignarro; Fiscal Year: 2001
  8. Arginase and Nitric Oxide in Atherosclerosis
    Louis Ignarro; Fiscal Year: 2004
  9. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
  10. STRUCTURE/FUNCTION STUDIES OF FATTY ACID AMIDE HYDROLASE
    Benjamin Cravatt; Fiscal Year: 2004

Detail Information

Publications272 found, 100 shown here

  1. pmc Improved diagnostic testing and malaria treatment practices in Zambia
    Davidson H Hamer
    Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
    JAMA 297:2227-31. 2007
    ....
  2. ncbi Efficacy of a new once-daily long-acting inhaled beta2-agonist indacaterol versus twice-daily formoterol in COPD
    Ronald Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    Thorax 65:473-9. 2010
    ..In previous studies, indacaterol provided 24 h bronchodilation on once-daily dosing with a fast onset of action. This study compared the efficacy and safety of indacaterol with the twice-daily LABA formoterol and placebo over 1 year...
  3. ncbi The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide
    Jesse Lo Verme
    Department of Pharmacology, 360 MSRII, University of California, Irvine, CA 92697 4625, USA
    Mol Pharmacol 67:15-9. 2005
    ..These findings indicate that PPAR-alpha mediates the anti-inflammatory effects of PEA and suggest that this fatty-acid ethanolamide may serve, like its analog OEA, as an endogenous ligand of PPAR-alpha...
  4. pmc Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural Tanzania
    Oliver J Sabot
    Malaria Control Team, Clinton Foundation HIV AIDS Initiative, Boston, Massachusetts, USA
    PLoS ONE 4:e6857. 2009
    ..To overcome this challenge, a global ACT subsidy has been proposed. We tested this proposal through a pilot program in rural Tanzania...
  5. pmc Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial
    Quique Bassat
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 4:e7871. 2009
    ..Dihydroartemisinin-piperaquine (DHA-PQP) is a promising fixed-dose ACT with limited information on its safety and efficacy in African children...
  6. ncbi Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
    Tiziana Genovese
    IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy
    J Pharmacol Exp Ther 326:12-23. 2008
    ..Together, the results indicate that PEA reduces inflammation and tissue injury associated with SCI and suggest a regulatory role for endogenous PPAR-alpha signaling in the inflammatory response associated with spinal cord trauma...
  7. ncbi Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trial
    Jacek Skarbinski
    Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Am J Trop Med Hyg 80:919-26. 2009
    ..30). RDTs could potentially improve malaria case management, but we urgently need to develop more effective strategies for implementing guidelines before large scale implementation...
  8. ncbi Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children
    Emmanuel Arinaitwe
    Makerere University University of California San Francisco Research Collaboration, University of California, San Francisco 94143, USA
    Clin Infect Dis 49:1629-37. 2009
    ..However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children...
  9. pmc In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
    Christin Sisowath
    Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 199:750-7. 2009
    ..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
  10. pmc In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1
    Leah Mwai
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, Kilifi, Kenya
    Antimicrob Agents Chemother 53:5069-73. 2009
    ..Therefore, the use of LM-artemether is likely to lead to the selection of more CQ-susceptible parasites...
  11. ncbi In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)
    Christin Sisowath
    Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    J Infect Dis 191:1014-7. 2005
    ..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
  12. pmc Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    J Infect Dis 194:528-35. 2006
    ..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
  13. pmc Malaria case-management following change of policy to universal parasitological diagnosis and targeted artemisinin-based combination therapy in Kenya
    Andrew Nyandigisi
    Division of Malaria Control, Ministry of Public Health and Sanitation, Nairobi, Kenya
    PLoS ONE 6:e24781. 2011
    ..We evaluated changes in health systems and case-management indicators between the baseline survey undertaken before implementation of the policy and the follow-up survey following the first year of the implementation activities...
  14. pmc Malaria drug shortages in Kenya: a major failure to provide access to effective treatment
    Beth B Kangwana
    Malaria Public Health and Epidemiology Group, Kenya Medical Research Institute Wellcome Trust Programme Nairobi, Kenya
    Am J Trop Med Hyg 80:737-8. 2009
    ..The shortage was in large part caused by a delayed procurement process. National ministries of health and the international community must address the current shortcomings facing antimalarial drug supply to the public sector...
  15. pmc SMS for Life: a pilot project to improve anti-malarial drug supply management in rural Tanzania using standard technology
    Jim Barrington
    SMS for Life Program Director, Forum 1 P 94, Novartis Campus, CH 4056 Basel, Switzerland
    Malar J 9:298. 2010
    ..Lack of visibility of anti-malarial stock levels at the health facility level is an important contributor to this problem...
  16. pmc Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast
    Steffen Borrmann
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS ONE 6:e26005. 2011
    ..The emergence of artemisinin-resistant P. falciparum malaria in South-East Asia highlights the need for continued global surveillance of the efficacy of artemisinin-based combination therapies...
  17. ncbi Formoterol mono- and combination therapy with tiotropium in patients with COPD: a 6-month study
    Claus Vogelmeier
    Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Giessen und Marburg, Standort Marburg Baldingerstrasse, D 35043 Marburg, Germany
    Respir Med 102:1511-20. 2008
    ..Combined bronchodilator therapy may be a valuable treatment option for patients with COPD...
  18. ncbi Adherence to treatment with artemether-lumefantrine for uncomplicated malaria in rural Malawi
    Kimberly E Mace
    Division of Parasitic Diseases and Malaria, Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 53:772-9. 2011
    ..Because of concerns about the complex dosing schedule, we assessed patient adherence to AL 2 years after routine implementation...
  19. pmc Changes in health workers' malaria diagnosis and treatment practices in Kenya
    Elizabeth Juma
    Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO, Nairobi, Kenya
    Malar J 10:1. 2011
    ..Three years after the policy implementation, health workers' adherence to malaria diagnosis and treatment recommendations was evaluated...
  20. pmc Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 53:3837-46. 2009
    ..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed...
  21. ncbi Comparison of tiotropium once daily, formoterol twice daily and both combined once daily in patients with COPD
    J A Van Noord
    Dept of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands
    Eur Respir J 26:214-22. 2005
    ..i.d. A combination of both drugs q.d. was most effective and provided an additive effect throughout the 24-h dosing interval...
  22. pmc Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
    Carlos Solorzano
    Department of Pharmacology, University of California, Irvine, CA 92697 4624, USA
    Proc Natl Acad Sci U S A 106:20966-71. 2009
    ..The PEA-hydrolyzing amidase NAAA may provide a previously undescribed target for antiinflammatory medicines...
  23. ncbi Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial
    Antoinette K Tshefu
    Ecole de Santé Publique, Faculte de Medecine, Universite de Kinshasa, Kinshasa, Democratic Republic of the Congo
    Lancet 375:1457-67. 2010
    ..We compared the efficacy and safety of pyronaridine-artesunate with that of artemether-lumefantrine for treatment of uncomplicated P falciparum malaria...
  24. pmc Quality of malaria case management at outpatient health facilities in Angola
    Alexander K Rowe
    Centers for Disease Control and Prevention, Atlanta, USA
    Malar J 8:275. 2009
    ..Implementation was complicated by a policy that was sometimes ambiguous...
  25. ncbi Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Eur J Pharmacol 401:121-30. 2000
    ..In contrast, the inhibition by palmitoylethanolamide does not appear to be mediated by cannabinoid receptors...
  26. ncbi Effects of tiotropium with and without formoterol on airflow obstruction and resting hyperinflation in patients with COPD
    Jan A van Noord
    Department of Respiratory Diseases, Atrium Medisch Centrum, Henri Dunantstraat 5, 6419 PC Heerlen, The Netherlands
    Chest 129:509-17. 2006
    ..The combination of short-acting beta(2)-agonists and anticholinergics in the treatment of COPD has been well documented, but data on combination of long-acting agents are lacking...
  27. pmc Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial
    Jane Achan
    Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
    BMJ 339:b2763. 2009
    ..To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children...
  28. ncbi Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury
    Emanuela Esposito
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Brain Behav Immun 25:1099-112. 2011
    ....
  29. ncbi Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial
    Patrice Piola
    Epicentre, Paris, France
    Lancet Infect Dis 10:762-9. 2010
    ..We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda...
  30. ncbi Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda
    Carole Fogg
    Epicentre, Paris, France
    Am J Trop Med Hyg 71:525-30. 2004
    ..The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations...
  31. ncbi Deploying artemether-lumefantrine with rapid testing in Ethiopian communities: impact on malaria morbidity, mortality and healthcare resources
    Hailemariam Lemma
    Tigray Health Bureau, Mekelle, Ethiopia
    Trop Med Int Health 15:241-50. 2010
    ....
  32. pmc Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia
    Karen I Barnes
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town Faculty of Health Sciences, Anzio Road, Observatory, 7925, South Africa
    Malar J 8:S8. 2009
    ..Artemisinin-based combination therapy has made a substantial contribution to reducing the burden of malaria in sub-Saharan Africa...
  33. pmc Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania
    Abdunoor M Kabanywanyi
    Ifakara Health Institute, P, O, Box 78373, Kiko Avenue, Old Bagamoyo Road, Mikocheni, Dar es Salaam, Tanzania
    Malar J 9:48. 2010
    ..Controlled clinical trials have shown that a six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates >95% with good tolerability...
  34. pmc Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia
    Pharath Lim
    Institut Pasteur in Cambodia, Phnom Penh, Cambodia
    Malar J 8:11. 2009
    ....
  35. ncbi The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
    ..The findings presented here, in addition to prove the beneficial effects of PEA in chronic pain, identify new potential targets for analgesic medicine...
  36. pmc Efficacy and tolerability of budesonide/formoterol in one hydrofluoroalkane pressurized metered-dose inhaler in patients with chronic obstructive pulmonary disease: results from a 1-year randomized controlled clinical trial
    Stephen I Rennard
    Pulmonary Critical Care, Allergy and Sleep Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5885, USA
    Drugs 69:549-65. 2009
    ....
  37. ncbi A trial of combination antimalarial therapies in children from Papua New Guinea
    Harin A Karunajeewa
    School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
    N Engl J Med 359:2545-57. 2008
    ..Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea...
  38. pmc Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malaria
    Sam Salman
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia
    Antimicrob Agents Chemother 55:5306-13. 2011
    ....
  39. pmc Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine
    Nahla B Gadalla
    Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan
    Antimicrob Agents Chemother 55:5408-11. 2011
    ..One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up...
  40. pmc Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance
    Maria Isabel Veiga
    Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e20212. 2011
    ..Our work unveils new candidate markers of P. falciparum multidrug resistance in vitro, while contributing to the understanding of subjacent genetic complexity, essential for future evidence-based drug policy decisions...
  41. pmc Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial
    Kojo Yeboah-Antwi
    Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000340. 2010
    ..This study was designed to assess the effectiveness and feasibility of using CHWs to manage nonsevere pneumonia and uncomplicated malaria with the aid of rapid diagnostic tests (RDTs)...
  42. pmc Population pharmacokinetics and therapeutic response of CGP 56697 (artemether + benflumetol) in malaria patients
    F Ezzet
    Novartis Pharma AG, Basel, Switzerland
    Br J Clin Pharmacol 46:553-61. 1998
    ..While the 4 x 4 dose regimen is very effective in most endemic areas, the poorer absorption (2.5 fold lower than in China) and the more resistant parasites in Thailand require higher doses of this drug...
  43. pmc Adherence to prescribed artemisinin-based combination therapy in Garissa and Bunyala districts, Kenya
    Harriet Lawford
    The MENTOR Initiative, La Prade, 11150, Villasavary, France
    Malar J 10:281. 2011
    ..This study reports adherence to a specific ACT, artemether-lumefantrine (AL), under conditions of routine clinical practice in Kenya...
  44. ncbi Anticancer effects of synthetic phosphoethanolamine on Ehrlich ascites tumor: an experimental study
    Adilson Kleber Ferreira
    Biochemistry and Biophysical Laboratory, Butantan Institute, Sao Paulo, Brazil
    Anticancer Res 32:95-104. 2012
    ..The aim of this study was to investigate the synthetic phosphoethanolamine (Pho-s) as a new anticancer agent...
  45. pmc Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda
    Joel Tarning
    Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Malar J 11:293. 2012
    ..The objective of this study was to evaluate the population pharmacokinetic properties of artemether and its active metabolite dihydroartemisinin in pregnant women with uncomplicated P. falciparum malaria in Uganda...
  46. ncbi Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-α
    Marco Koch
    Dr Senckenbergische Anatomie, Institut für Anatomie II, Goethe Universitat, Frankfurt am Main, Germany
    Neurotox Res 19:330-40. 2011
    ..In addition to classical endocannabinoids, PEA-mediated PPAR-alpha activation represents a possible target for therapeutic interventions to mitigate symptoms of secondary neuronal damage...
  47. ncbi Efficacy and effectiveness of artemether-lumefantrine after initial and repeated treatment in children <5 years of age with acute uncomplicated Plasmodium falciparum malaria in rural Tanzania: a randomized trial
    Billy E Ngasala
    Malaria Research, Infectious Diseases Unit, Department of Medicine Solna, Karolinska University Hospital, Stockholm, Sweden
    Clin Infect Dis 52:873-82. 2011
    ....
  48. ncbi The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa
    Christin Sisowath
    Malaria Research Unit, Division of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Trop Med Int Health 12:736-42. 2007
    ..e. pfmdr1 gene amplification, pfmdr1 Y184F, S1034C, N1042D, D1246Y, pfcrt S163R and PfATP6 S769N...
  49. ncbi Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans
    R Preston Mason
    Elucida Research, Beverly, Massachusetts, USA
    Circulation 112:3795-801. 2005
    ..The ability to pharmacologically reverse endothelial dysfunction in blacks was tested with nebivolol, a beta1-selective agent with vasodilating and antioxidant properties...
  50. ncbi Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
    Drugs 68:1975-2000. 2008
    ..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD...
  51. pmc Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study
    Billy E Ngasala
    Malaria Research, Infectious Diseases Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Malar J 10:64. 2011
    ....
  52. pmc Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria
    G S Humphreys
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Antimicrob Agents Chemother 51:991-7. 2007
    ..25; 95% confidence interval, 4.17 to 1441; P, <0.001). We conclude that AL and AQ exert opposite within-host selective effects on the Pfmdr1 gene of P. falciparum...
  53. pmc The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial
    Beth P Kangwana
    Malaria Public Health and Epidemiology Group, Kenya Medical Research Institute Wellcome Trust Research Programme, Kenya
    PLoS Med 8:e1000437. 2011
    ..This study in western Kenya aimed to evaluate the impact of providing subsidized artemether-lumefantrine (AL) through retail providers on the coverage of prompt, effective antimalarial treatment for febrile children aged 3-59 months...
  54. ncbi Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase
    Kazuhito Tsuboi
    Department of Biochemistry, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    J Biol Chem 280:11082-92. 2005
    ..These results demonstrated that NAAA is a novel N-acylethanolamine-hydrolyzing enzyme that shows structural and functional similarity to acid ceramidase...
  55. pmc A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya
    Petra F Mens
    Koninklijk Instituut voor de Tropen KIT Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands
    Malar J 7:237. 2008
    ....
  56. pmc Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic
    Christian Dokomajilar
    Department of Medicine, University of California San Francisco, San Francisco General Hospital, Box 0811, San Francisco, CA 94143, USA
    Antimicrob Agents Chemother 50:1893-5. 2006
    ..All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response...
  57. ncbi Increased prevalence of the Plasmodium falciparum Pfmdr1 86N genotype among field isolates from Franceville, Gabon after replacement of chloroquine by artemether-lumefantrine and artesunate-mefloquine
    Jean Bernard Lekana-Douki
    Unité de Parasitologie Médicale UPARAM, Centre International de Recherches Medicales de Franceville CIRMF, B P 769 Franceville, Gabon
    Infect Genet Evol 11:512-7. 2011
    ....
  58. pmc Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial
    Jean Louis A Ndiaye
    Department of Medical Parasitology, Medical Faculty, Universite Cheikh Anta Diop, Dakar, Senegal
    Malar J 10:237. 2011
    ....
  59. ncbi Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain
    Harald S Hansen
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
    Exp Neurol 224:48-55. 2010
    ....
  60. pmc Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity to reduce the burden of malaria?
    Bernhards Ogutu
    Walter Reed Project Centre for Clinical Research Kenya Medical Research Institute, Nairobi, Kenya
    Malar J 9:30. 2010
    ..The potential of this intervention was considered by key scientists in the field at an Advisory Board meeting held in Basel, in April 2009. This article summarizes the discussions that took place among the participants...
  61. ncbi Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria
    M A van Agtmael
    Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands
    Int J Antimicrob Agents 12:151-8. 1999
    ..We suggest that auto-induction of gut mucosa enzymes and/or liver enzymes causes a time-dependent increase in first-pass metabolisation of artemether...
  62. pmc In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia
    Jimee Hwang
    U S Centers for Disease Control and Prevention, Atlanta, GA, USA
    Malar J 10:209. 2011
    ..In Ethiopia, artemether-lumefantrine (AL) has been the first-line treatment for uncomplicated P. falciparum malaria since 2004...
  63. ncbi Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness
    Priit Kampus
    Department of Cardiology, University of Tartu, 8 Puusepa St, Tartu 51014, Estonia
    Hypertension 57:1122-8. 2011
    ....
  64. pmc Evaluation of recurrent parasitemia after artemether-lumefantrine treatment for uncomplicated malaria in children in western Kenya
    Joseph V Woodring
    Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Am J Trop Med Hyg 83:458-64. 2010
    ..This underscores patient counseling on completing all treatment doses for optimal protection from RP...
  65. ncbi The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD
    Mario Cazzola
    Unit of Pneumology and Allergology, Department of Respiratory Medicine, A Cardarelli Hospital, Via del Parco Margherita 24, Naples 80121, Italy
    Pulm Pharmacol Ther 17:35-9. 2004
    ..Since tiotropium ensures prolonged bronchodilation, whereas formoterol adds fast onset and a greater peak effect, the two drugs appear complementary...
  66. pmc Beta3-adrenoreceptor stimulation ameliorates myocardial ischemia-reperfusion injury via endothelial nitric oxide synthase and neuronal nitric oxide synthase activation
    Juan P Aragon
    Department of Surgery, Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, Georgia 30308, USA
    J Am Coll Cardiol 58:2683-91. 2011
    ..This paper examined whether nebivolol protects the heart via nitric oxide (NO) synthase and NO-dependent signaling in an in vivo model of acute myocardial infarction...
  67. ncbi Effect of long-acting beta-agonists on the frequency of COPD exacerbations: a meta-analysis
    J Wang
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Clin Pharm Ther 37:204-11. 2012
    ..However, the evidence that long-acting beta-agonists alone can reduce the rate of COPD exacerbations is not conclusive. This meta-analysis was performed to evaluate their effect on the frequency of exacerbations...
  68. ncbi Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine
    Andreas Artmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1781:200-12. 2008
    ....
  69. pmc Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase 2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania
    Eva Maria Staehli Hodel
    Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland
    Antimicrob Agents Chemother 57:950-8. 2013
    ....
  70. pmc Efficacy of indacaterol 75 μg versus fixed-dose combinations of formoterol-budesonide or salmeterol-fluticasone for COPD: a network meta-analysis
    Shannon Cope
    Mapi Consultancy, Boston, MA 02114, USA
    Int J Chron Obstruct Pulmon Dis 7:415-20. 2012
    ....
  71. ncbi Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Thailand
    Trop Med Int Health 12:201-8. 2007
    ..If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance...
  72. ncbi Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus) versus artemether-lumefantrine (Coartem) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast
    Babacar Faye
    Service de Parasitologie Mycologie Médicale, Universite Cheikh Anta Diop, Dakar Fann, Senegal
    Trop Med Int Health 15:608-13. 2010
    ....
  73. ncbi The effects of a pre-season treatment with effective antimalarials on subsequent malaria morbidity in under five-year-old children living in high and seasonal malaria transmission area of Burkina Faso
    Alphonse Ouedraogo
    Centre National de Recherche et de Formation sur le Paludisme, Ministere de la Sante, Ouagadougou, Burkina Faso Groupe de Recherche Action en Santé, Ouagadougou, Burkina Faso
    Trop Med Int Health 15:1315-21. 2010
    ..To evaluate the effects of pre-season treatment with single dose of sulfadoxine-pyrimethamine (SP) or artemether-lumefantrine (AL) on subsequent malaria morbidity in under-fives...
  74. ncbi No hearing loss associated with the use of artemether-lumefantrine to treat experimental human malaria
    Matthew B B McCall
    Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Trans R Soc Trop Med Hyg 100:1098-104. 2006
    ..Our results support the continued implementation of artemisinin derivatives in the fight against drug-resistant malaria...
  75. ncbi Artemisinin-based combinations
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Curr Opin Infect Dis 18:531-6. 2005
    ..Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world...
  76. ncbi Inhaled corticosteroids or long-acting beta-agonists alone or in fixed-dose combinations in asthma treatment: a systematic review of fluticasone/budesonide and formoterol/salmeterol
    Christian Frois
    Analysis Group, Boston, Massachusetts 02199 7636, USA
    Clin Ther 31:2779-803. 2009
    ..Inhaled corticosteroids (ICSs) and long-acting inhaled beta(2)-agonists (LABAs) are recommended treatment options for asthma...
  77. pmc Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trials
    Donald P Tashkin
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Int J Chron Obstruct Pulmon Dis 7:73-86. 2012
    ....
  78. ncbi Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trial
    Donald P Tashkin
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Respir Med 102:479-87. 2008
    ..2% vs. 1.5%). Nebulized formoterol fumarate in combination with tiotropium provided statistically and clinically significant improvements in bronchodilation and symptom control over tiotropium alone and demonstrated good tolerability...
  79. ncbi The search for the palmitoylethanolamide receptor
    Jesse LoVerme
    Center for Drug Discovery, University of California, Irvine, CA 92697 4260, USA
    Life Sci 77:1685-98. 2005
    ..Here we outline the history of PEA, starting with its initial discovery in the 1950s, and discuss the pharmacological properties of this compound, particularly in regards to its ability to activate PPAR-alpha...
  80. pmc Effects of formoterol on contraction and Ca2+ signaling of mouse airway smooth muscle cells
    Philippe Delmotte
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Am J Respir Cell Mol Biol 42:373-81. 2010
    ..This action was quickly initiated at high concentrations by decreasing the frequency of Ca(2+) oscillations, but was more usually mediated at lower concentrations by decreasing the Ca(2+) sensitivity of the SMCs...
  81. pmc Comparative efficacy of indacaterol 150 μg and 300 μg versus fixed-dose combinations of formoterol + budesonide or salmeterol + fluticasone for the treatment of chronic obstructive pulmonary disease--a network meta-analysis
    Shannon Cope
    Mapi Values, Boston, MA, USA
    Int J Chron Obstruct Pulmon Dis 6:329-44. 2011
    ....
  82. ncbi Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells
    Hanke Mollnau
    Abteilung fur Kardiologie, Universitats Krankenhaus Eppendorf, University of Hamburg, Hamburg, Germany
    Arterioscler Thromb Vasc Biol 23:615-21. 2003
    ..With the present studies we sought to determine whether beta receptor blockade with nebivolol may improve endothelial function in hyperlipidemia and whether this is attributable to reductions in vascular oxidative stress...
  83. ncbi Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57)
    Kanako Sakuyama
    Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Drug Metab Dispos 36:2460-7. 2008
    ..51, CYP2D6.54, and CYP2D6.55), and high activity in one (CYP2D6.53) compared with the wild type. Analysis of CYP2D6 variant proteins can be useful for predicting CYP2D6 phenotypes and could be applied to personalized drug therapy...
  84. ncbi Budesonide/formoterol vs. salmeterol/fluticasone in COPD: a systematic review and adjusted indirect comparison of pneumonia in randomised controlled trials
    D M G Halpin
    Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, UK
    Int J Clin Pract 65:764-74. 2011
    ....
  85. ncbi Bronchodilator responsiveness and onset of effect with budesonide/formoterol pMDI in COPD
    Bartolome R Celli
    Harvard University, Brigham and Women s Hospital, Pulmonary and Critical Care Medicine, Boston, MA 02115, USA
    Respir Med 105:1176-88. 2011
    ..We also evaluated the speed of onset of bronchodilation...
  86. pmc Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria
    Anja M Carlsson
    Infectious Diseases Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Retzius väg 10, S 171 77 Stockholm, Sweden
    Malar J 10:380. 2011
    ..This study aimed to explore Plasmodium falciparum population dynamics during the early phase of anti-malarial drug treatment with artemisinin-based combination therapy in children with clinical malaria in a high transmission area in Africa...
  87. pmc Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease
    Luis Javier Nannini
    Pulmonary Section, Hospital E Peron, G Baigorria, Argentina
    Cochrane Database Syst Rev 9:CD006829. 2012
    ..This updated review compared compound LABA plus ICS therapy (LABA/ICS) with the LABA component drug given alone...
  88. ncbi N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)
    Natsuo Ueda
    Department of Biochemistry, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa, Japan
    Prog Lipid Res 49:299-315. 2010
    ..In this article we discuss recent progress in the studies on the enzymes involved in the biosynthesis and degradation of NAEs with special reference to NAAA...
  89. pmc Implementation of Home based management of malaria in children reduces the work load for peripheral health facilities in a rural district of Burkina Faso
    Alfred B Tiono
    Centre National de Recherche et de Formation sur Paludisme, Ministère de Santé, Ouagadougou, Burkina Faso, West Africa
    Malar J 7:201. 2008
    ..However, the potential fall-out of this community-based strategy on the work burden at the peripheral health facilities level has never been investigated...
  90. pmc The use of artemether-lumefantrine for the treatment of uncomplicated Plasmodium vivax malaria
    Quique Bassat
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS Negl Trop Dis 5:e1325. 2011
    ..vivax, and in co-endemic areas where AL is already used routinely against P. falciparum and parasitological differentiation is not routinely performed or only clinical diagnosis is used...
  91. pmc 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism
    Darren Smart
    Neuroscience Research, Glaxo SmithKline Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK
    Br J Pharmacol 136:452-8. 2002
    1. The abilities of a series of saturated N-acyl ethanolamines and related compounds to affect the ability of anandamide (AEA) to produce a Ca2+ influx into human embryonic kidney cells expressing the human vanilloid receptor (hVR1-..
  92. pmc Adherence to a six-dose regimen of artemether-lumefantrine among uncomplicated Plasmodium falciparum patients in the Tigray Region, Ethiopia
    Hailemariam Lemma
    Tigray Health Bureau, Mekelle, Ethiopia
    Malar J 10:349. 2011
    ..The aim of this study was to measure patient adherence levels to the six-dose AL regimen for the treatment of uncomplicated P. falciparum malaria and to identify its determinant factors in rural areas of the Tigray region, Ethiopia..
  93. pmc The bioavailability and airway clearance of the steroid component of budesonide/formoterol and salmeterol/fluticasone after inhaled administration in patients with COPD and healthy subjects: a randomized controlled trial
    Chris Dalby
    Respiratory Medicine Unit, City Hospital Campus, Nottingham University, Nottingham, UK
    Respir Res 10:104. 2009
    ....
  94. ncbi Onset of action of single doses of formoterol administered via Turbuhaler in patients with stable COPD
    M Cazzola
    Division of Pneumology and Allergology and Unit of Respiratory Clinical Pharmacology, A Cardarelli Hospital, Naples, Italy
    Pulm Pharmacol Ther 14:41-5. 2001
    ..Again, there was no significant difference (P= 0.817) between the four active treatments. Formoterol Turbuhaler 12 microg and 24 microg caused bronchodilation as rapidly as salbutamol 400 microg and 800 microg given via pMDI...
  95. pmc Pharmacokinetics of artemether and dihydroartemisinin in healthy Pakistani male volunteers treated with artemether-lumefantrine
    Shabana Ali
    Department of Pharmacology and Therapeutics, Army Medical College, National University of Sciences and Technology NUST, Islamabad, Pakistan
    Malar J 9:275. 2010
    ..The aim of this study was to evaluate the pharmacokinetics of artemether and its active metabolite, dihydroartemisinin, in healthy Pakistani volunteers...
  96. pmc Efficacy of artemether-lumefantrine in treatment of malaria among under-fives and prevalence of drug resistance markers in Igombe-Mwanza, north-western Tanzania
    Erasmus Kamugisha
    Weill Bugando University College of Health Sciences, Mwanza, Tanzania
    Malar J 11:58. 2012
    ....
  97. pmc Malaria case-management under artemether-lumefantrine treatment policy in Uganda
    Dejan Zurovac
    Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, Nairobi, Kenya
    Malar J 7:181. 2008
    ..Here the quality of AL case-management is reported from Uganda; approximately one year after AL replaced combination of chloroquine and sulphadoxine-pyrimethamine (CQ+SP) as recommended first line treatment for uncomplicated malaria...
  98. ncbi Cardio- and cerebrovascular safety of indacaterol vs formoterol, salmeterol, tiotropium and placebo in COPD
    Heinrich Worth
    Medical Department I, Klinikum Fürth, Jakob Henle Str 1, D 90766 Fürth, Germany
    Respir Med 105:571-9. 2011
    ..As COPD patients commonly suffer cardio- and cerebrovascular (CCV) co-morbidities, our purpose was to establish the CCV safety profile of indacaterol, a novel, inhaled, long-acting β(2)-agonist for COPD...
  99. pmc Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria
    C T Happi
    Malaria Research Laboratories, IMRAT, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Antimicrob Agents Chemother 53:888-95. 2009
    ..Pfmdr1 polymorphisms may result in reduction in the therapeutic efficacy of this newly adopted combination treatment for uncomplicated falciparum malaria in Saharan countries of Africa...
  100. ncbi Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats
    Jorge Toblli
    Laboratory of Experimental Medicine, Hospital Aleman, Argentina
    J Hypertens 28:1007-19. 2010
    ..Although effective in reducing blood pressure, therapy with a first-generation [beta]-blocker is currently controversial in metabolic syndrome due to its negative impact on carbohydrate and lipid metabolism...
  101. pmc Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets
    A Berger
    Nestle Research Center, Nestec Ltd, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Proc Natl Acad Sci U S A 98:6402-6. 2001
    ....

Research Grants65

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. HEAD GROUP INTERACTIONS IN MEMBRANES AND MICELLES
    KENNETH DILL; Fiscal Year: 1991
    ..added salt, and (ii) containing zwitterionic head groups, particularly phosphatidyl cholines and phosphatidyl ethanolamines, as a function of temperature...
  3. Causal and Nonlinear Models of Cancer Risk Among Autoworkers
    Ellen Eisen; Fiscal Year: 2009
    ..known carcinogens, such as chlorinated compounds and polycyclic aromatic hydrocarbons in oil-based fluids, and ethanolamines and nitrosamines in water-based fluids...
  4. LUNG HEALTH STUDY--LONG TERM FOLLOW UP
    Donald Tashkin; Fiscal Year: 2002
    ..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
  5. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  6. SCLERODERMA LUNG STUDY
    Donald Tashkin; Fiscal Year: 2003
    ..abstract_text> ..
  7. CYTOSTATIC ROLE OF THE ARGININE-NITRIC OXIDE PATHWAY
    Louis Ignarro; Fiscal Year: 2001
    ..The proposed research should advance our understanding of the biological role of NO synthase in regulating cell proliferation. ..
  8. Arginase and Nitric Oxide in Atherosclerosis
    Louis Ignarro; Fiscal Year: 2004
    ..The feasibility of this approach is borne out by the extensive preliminary data that support the central hypothesis. ..
  9. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
    ..The proposed research represents a continuing long-term effort to elucidate the biological factors influencing the vascular and related actions of NO in health and disease. ..
  10. STRUCTURE/FUNCTION STUDIES OF FATTY ACID AMIDE HYDROLASE
    Benjamin Cravatt; Fiscal Year: 2004
    ..abstract_text> ..
  11. Drug Abuse Related Polymorphism in Fatty Acid Amide Hydrolase
    Benjamin Cravatt; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Enzymes That Regulate Fatty Acid Amide Function In Vivo
    Benjamin Cravatt; Fiscal Year: 2009
    ..These studies will elucidate the functions of key enzymes that regulate FAA signaling in vivo. These proteins may represent new targets for the treatment of pain, addiction, and other neurological disorders. ..
  13. CHEMICAL APPROACHES FOR ACTIVITY BASED PROTEOMICS
    Benjamin Cravatt; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. MODERATE ALCOHOL USE--CARDIOVASCULAR RISKS AND BENEFITS
    Thomas Giles; Fiscal Year: 2001
    ..The exacerbation or prevention of EIH will be related to drug effects on the cell-signaling pathway. This research can define the cell-signaling pathway in EIH and provide new and novel approaches to treating EIH. ..
  15. Microarray Platform for Profiling Cancer Proteases
    Benjamin Cravatt; Fiscal Year: 2008
    ..These proteases may in turn represent valuable new markers and targets for the diagnosis and treatment of cancer. ..
  16. Burden of Malaria in Pregnancy in India
    Davidson Hamer; Fiscal Year: 2007
    ..The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]..
  17. Response to Beta2-Agonists in Acute Severe Asthma
    Nicola Hanania; Fiscal Year: 2008
    ..abstract_text> ..
  18. Co(II)-Radical Pair Dynamics in B12 Enzyme Catalysis
    Kurt Warncke; Fiscal Year: 2008
    ..abstract_text> ..
  19. Image-Guided Pro-Drug/Enzyme Therapy
    Zaver Bhujwalla; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. CARE Network - Tucson Clinical Center
    Fernando Martinez; Fiscal Year: 2008
    ..abstract_text> ..
  21. IL8 and GATA3-mediated Pathways in Asthma Exacerbations
    Fernando Martinez; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable]..
  22. MULTIDISCIPLINARY METHODS FOR CLINICAL AND EPIDEMIOLOGICAL RESEARCH
    Rosemarie Bowler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Characterization of a novel brain cannabinoid ligand
    Daniele Piomelli; Fiscal Year: 2010
    ..The objective of our research is to understand how these transmitters are produced and eliminated, and discover innovative medicines that target these processes. ..
  24. THE ROLE OF SULFATIDES IN ALZHEIMER'S DISEASE
    Xianlin Han; Fiscal Year: 2008
    ..abstract_text> ..
  25. Interferons Modulate Airway Smooth Muscle Growth
    Reynold Panettieri; Fiscal Year: 2008
    ....
  26. PHOSPHOLIPID METABOLISM AND MEMBRANE FUNCTION
    GEORGE CARMAN; Fiscal Year: 2009
    ..Zinc transport function will be addressed with mutants defective in phospholipid synthesis, and with Zrtlp reconstituted into unilamellar vesicles with varying phospholipid composition. ..
  27. Severe Asthma From Respiratory Infections
    William W Busse; Fiscal Year: 2010
    ..These studies will provide new insights into the mechanisms of asthma, particularly severe disease, and possibilities of new approaches to treatment. ..
  28. Genotype-Phenotype Interactions in Severe Asthma
    EUGENE ROLAND BLEECKER; Fiscal Year: 2010
    ..We feel strongly that collaborative research is necessary to meet the goals of this RFA and is crucial to genetic studies. We will continue to participate as an active member of SARP II. ..
  29. Role of Endocannabinoids in the Behavioral Consequences of Social Isolation
    Daniele Piomelli; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. Obesity, Inflammation and Response to Therapy in Asthma
    EVERETT RAND SUTHERLAND; Fiscal Year: 2010
    ..End of Abstract) ..
  31. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  32. MULTIDICIPLINARY FUNCTIONAL IMAGING OF CANCER
    Zaver Bhujwalla; Fiscal Year: 2002
    ..abstract_text> ..
  33. Partnership Program to Reduce Cardiovascular Disparities
    Elijah Saunders; Fiscal Year: 2008
    ..We strongly expect improved outcomes/awareness of cardiovascular health among minority patients serviced by both BSBHS and UMB. ..
  34. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  35. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  36. Analgesic tolerance to mu-delta opioid bivalent ligands
    NATALIE LENARD; Fiscal Year: 2006
    ..3) To determine whether tolerance and physical dependence develop during chronic administration of the opioid receptor bivalent ligands. ..
  37. Regulation of Angiogenesis via EphB4 Signaling
    JENA STEINLE; Fiscal Year: 2002
    ..These results from both mesenteric and retinal endothelial cells will greatly increase our understanding of Eph B4 receptor regulation of the various stages of angiogenesis. ..
  38. Brain Endocannabinoids and Chronic Stress
    Cecilia Hillard; Fiscal Year: 2005
    ..The successful completion of these studies will enhance our understanding of the processes involved in the adaptation of the brain to chronic stress. ..
  39. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  40. CHROMOSOME 5Q GENE VARIANTS AND ASTHMA-RELATED TRAITS
    Fernando Martinez; Fiscal Year: 2004
    ..This will allow to better understand the genetic influence that determine asthma risk. ..
  41. SOURCES OF NEUROACTIVE ANALGESIC N-ACYLETHANOLAMINES
    Kent Chapman; Fiscal Year: 2002
    ..as well as by molecular genetic approaches (cultures derived from CBI-knockout mice). Results from this research should target new botanical sources for development as neuroactive therapeutics. ..
  42. ORGANIC PHOSPHATE METABOLISM IN LENS STRESS & CATARACT
    HOWARD JERNIGAN; Fiscal Year: 2003
    ....
  43. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..abstract_text> ..
  44. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    Kurt Warncke; Fiscal Year: 2003
    ..A sustained high impact of the EPR spectrometer on biomedicine is therefore anticipated. ..
  45. SIGNALING BY VASOPRESSIN--ARTERIAL SMOOTH MUSCLE CELLS
    KENNETH BYRON; Fiscal Year: 2002
    ..Finally, the effects of AVP and other hormones on [Ca2+]i and membrane currents will be examined in freshly isolated smooth muscle cells from rat mesenteric arteries. ..
  46. Effect of Daily Exercise on Cardiac Autonomic Regulation
    GEORGE BILLMAN; Fiscal Year: 2005
    ..Ventricular contractile responses to Beta1- and Beta2-adrenoceptor stimulation will be examined in vivo by echocardiography and in vitro by single cell fluorescence microscopy/video edge detection. ..
  47. GENETIC REGULATION OF IMMUNE MATURATION IN ASTHMA
    Fernando Martinez; Fiscal Year: 2001
    ....
  48. Genetic studies in difficult to treat asthma: TENOR
    Eugene Bleecker; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. IDENTIFICATION OF AN ASTHMA SUSCEPTIBILITY GENE ON 3P
    Eugene Bleecker; Fiscal Year: 2004
    ..As part of this project, it will be very important to interact with other funded investigators to determine the impact of each genetic locus and to investigate gene-gene interactions. ..
  50. INFLAMMATORY APOPTOSIS AFTER SPINAL CORD INJURY
    Chung Hsu; Fiscal Year: 2001
    ..The ultimate goal of this project is to enhance functional recovery after SCI through a reduction in ODC death. ..
  51. Msec Polymerase Chain Reaction with fMolar Detection Sensitivity using SPR
    DONALD ROPER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  52. Keystone Symposium on Stroke, March 9-14, 2002
    Chung Hsu; Fiscal Year: 2002
    ..This conference, focusing on fundamental basic science on stroke, will be a much needed vehicle to advance stroke research. ..
  53. IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYA
    Chandy John; Fiscal Year: 2002
    ..falciparum antigens to susceptibility to infection and disease is important in the evaluation of these antigens as malaria vaccine candidates. ..
  54. In vivo Substrate Utilization in the Newborn Rat Brain
    Raghavendra Rao; Fiscal Year: 2006
    ....
  55. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ....
  56. MECHANISMS REGULATING AIRWAY MUSCLE GROWTH
    Reynold Panettieri; Fiscal Year: 2003
    ..These studies will define the mechanism by which agonists induce ASM cell growth such that new issues in the pathogenesis of asthma will be addressed and therapeutic measures to prevent these alterations can be developed. ..
  57. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..research grant ..
  58. Mechanisms Regulation Functions of Airway Smooth Muscle
    Reynold Panettieri; Fiscal Year: 2007
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
  59. CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANS
    Stephen Peters; Fiscal Year: 2001
    ....
  60. MECHANISMS OF RHINOVIRUS INDUCED ASTHMA
    William Busse; Fiscal Year: 2002
    ..The proposed studies will provide new evidence as the mechanisms by which RV-infected epithelial cells cause granulocytic bronchial inflammation and asthma exacerbations. ..
  61. Mechanisms of VEGF modulation of smooth muscle function
    Reynold Panettieri; Fiscal Year: 2009
    ..abstract_text> ..
  62. Ozone ALTERS Airway Smooth Muscle FUNCTION IN ASTHMA
    Reynold Panettieri; Fiscal Year: 2008
    ..These studies will identify the mechanisms by which ozone enhances allergen-induced AHR and provide insight into new therapeutic targets to prevent asthma exacerbations and decrease asthma morbidity and mortality. ..
  63. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 2002
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  64. Cardiac Contraction-Relaxation Coupling
    PAULUS JANSSEN; Fiscal Year: 2008
    ....