alcohols

Summary

Summary: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. pmc The cytochrome P450 enzyme CYP96A15 is the midchain alkane hydroxylase responsible for formation of secondary alcohols and ketones in stem cuticular wax of Arabidopsis
    Stephen Greer
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
    Plant Physiol 145:653-67. 2007
  2. ncbi Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action
    Yohani Perez
    Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba
    J Nat Med 67:182-9. 2013
  3. ncbi Effects of alcohols, povidone-iodine and hydrogen peroxide on biofilms of Staphylococcus epidermidis
    Elisabeth Presterl
    Division of Infectious Diseases, Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Antimicrob Chemother 60:417-20. 2007
  4. ncbi New microbial fuels: a biotech perspective
    Mathew A Rude
    LS9, Inc, South San Francisco, CA 94080, USA
    Curr Opin Microbiol 12:274-81. 2009
  5. ncbi Formation of acetaldehyde-derived DNA adducts due to alcohol exposure
    Hsu Sheng Yu
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Chem Biol Interact 188:367-75. 2010
  6. pmc A stereoselective inverting sec-alkylsulfatase for the deracemization of sec-alcohols
    Markus Schober
    Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    Org Lett 13:4296-9. 2011
  7. pmc Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
    Jose L Avalos
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Biotechnol 31:335-41. 2013
  8. pmc Is there a specific receptor for anesthetics? Contrary effects of alcohols and fatty acids on phase transition and bioluminescence of firefly luciferase
    I Ueda
    Anesthesia 112A, Department of Veterans Administration Medical Center, and University of Utah School of Medicine, Salt Lake City, Utah 84148 USA
    Biophys J 75:1052-7. 1998
  9. ncbi Binding specificity of locust odorant binding protein and its key binding site for initial recognition of alcohols
    Quan Yong Jiang
    Key Lab for Biological Control of the Ministry of Agriculture, China Agricultural University, Beijing 100193, China
    Insect Biochem Mol Biol 39:440-7. 2009
  10. pmc LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster
    M S Kim
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Genetics 150:711-21. 1998

Detail Information

Publications362 found, 100 shown here

  1. pmc The cytochrome P450 enzyme CYP96A15 is the midchain alkane hydroxylase responsible for formation of secondary alcohols and ketones in stem cuticular wax of Arabidopsis
    Stephen Greer
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
    Plant Physiol 145:653-67. 2007
    ..wax mixture on the inflorescence stems of Arabidopsis (Arabidopsis thaliana) is dominated by alkanes, secondary alcohols, and ketones, all thought to be formed sequentially in the decarbonylation pathway of wax biosynthesis...
  2. ncbi Protective effect of D-002, a mixture of beeswax alcohols, against indomethacin-induced gastric ulcers and mechanism of action
    Yohani Perez
    Centre of Natural Products, National Centre for Scientific Research, Havana, Cuba
    J Nat Med 67:182-9. 2013
    D-002, a mixture of higher aliphatic beeswax alcohols, produces gastroprotective and antioxidant effects...
  3. ncbi Effects of alcohols, povidone-iodine and hydrogen peroxide on biofilms of Staphylococcus epidermidis
    Elisabeth Presterl
    Division of Infectious Diseases, Department of Medicine I, Medical University of Vienna, Vienna, Austria
    J Antimicrob Chemother 60:417-20. 2007
    ....
  4. ncbi New microbial fuels: a biotech perspective
    Mathew A Rude
    LS9, Inc, South San Francisco, CA 94080, USA
    Curr Opin Microbiol 12:274-81. 2009
    ....
  5. ncbi Formation of acetaldehyde-derived DNA adducts due to alcohol exposure
    Hsu Sheng Yu
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Chem Biol Interact 188:367-75. 2010
    ..Future studies are needed to better characterize and to validate the roles of these DNA adducts in human study...
  6. pmc A stereoselective inverting sec-alkylsulfatase for the deracemization of sec-alcohols
    Markus Schober
    Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    Org Lett 13:4296-9. 2011
    ..This catalytic event, which does not have an analog in chemocatalysis, yields homochiral (S)-configurated alcohols and nonreacted sulfate esters...
  7. pmc Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
    Jose L Avalos
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Biotechnol 31:335-41. 2013
    ..Other benefits of compartmentalization may include increased availability of intermediates, removing the need to transport intermediates out of the mitochondrion and reducing the loss of intermediates to competing pathways...
  8. pmc Is there a specific receptor for anesthetics? Contrary effects of alcohols and fatty acids on phase transition and bioluminescence of firefly luciferase
    I Ueda
    Anesthesia 112A, Department of Veterans Administration Medical Center, and University of Utah School of Medicine, Salt Lake City, Utah 84148 USA
    Biophys J 75:1052-7. 1998
    ..This study compared the effects of long-chain n-alcohols (1-decanol to 1-octadecanol) and fatty acids (decanoic to octadecanoic acids) on firefly luciferase...
  9. ncbi Binding specificity of locust odorant binding protein and its key binding site for initial recognition of alcohols
    Quan Yong Jiang
    Key Lab for Biological Control of the Ministry of Agriculture, China Agricultural University, Beijing 100193, China
    Insect Biochem Mol Biol 39:440-7. 2009
    ..We suggest that, as a general rule, a hydrophilic amino acid at the entrance of the binding cavity participates in initial recognition of ligands, and contributes to ligand-binding specificity of OBPs...
  10. pmc LUSH odorant-binding protein mediates chemosensory responses to alcohols in Drosophila melanogaster
    M S Kim
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Genetics 150:711-21. 1998
    ..These findings provide direct evidence that odorant-binding proteins are required for normal chemosensory behavior in Drosophila and may partially determine the chemical specificity of olfactory neurons in vivo...
  11. ncbi Surrogate alcohols and their metabolites modify histone H3 acetylation: involvement of histone acetyl transferase and histone deacetylase
    Mahua Choudhury
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Alcohol Clin Exp Res 32:829-39. 2008
    Ethanol increases histone H3 acetylation in the rat liver. However, the effect of other carbon chain length alcohols, consumed as surrogate alcohols and used in industry, on H3 acetylation is unknown...
  12. ncbi Comparison of long-chain alcohols and other volatile compounds emitted from food-borne and related Gram positive and Gram negative bacteria
    Hesham Elgaali
    Department of Animal Sciences, University of Kentucky, Lexington, Kentucky 40546 0091, USA
    J Basic Microbiol 42:373-80. 2002
    Numerous reports have been published on the antimicrobial activity of synthetic volatile long chain alcohols, such as 1-decanol and 1-dodecanol, against bacteria and fungi...
  13. pmc Alcohol's effects on lipid bilayer properties
    Helgi I Ingolfsson
    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York, USA
    Biophys J 101:847-55. 2011
    b>Alcohols are known modulators of lipid bilayer properties. Their biological effects have long been attributed to their bilayer-modifying effects, but alcohols can also alter protein function through direct protein interactions...
  14. pmc Role of alcohols in growth, lipid composition, and membrane fluidity of yeasts, bacteria, and archaea
    Sarah Huffer
    Energy Biosciences Institute, University of California, Berkeley, CA 94720, USA
    Appl Environ Microbiol 77:6400-8. 2011
    ..has long been documented as a cause for decreased cell growth during exposure to ethanol, butanol, and other alcohols. Reinforcement of the membrane with more complex lipid components is thus thought to be beneficial for the ..
  15. pmc Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel
    Aditya Bhattacharji
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA, USA
    Br J Pharmacol 159:1475-85. 2010
    ..Here, we investigated the neuronal Shaw2 voltage-gated K(+) (K(v)) channel to ask whether the inhalational anaesthetic halothane and n-alcohols share a binding site near the activation gate of the channel.
  16. ncbi Biocatalytic ketone reduction: a green and efficient access to enantiopure alcohols
    Yan Ni
    Laboratory of Biocatalysis and Synthetic Biotechnology, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    Biotechnol Adv 30:1279-88. 2012
    Chiral secondary alcohols play an important role in pharmaceutical, agrochemical, and chemical industries...
  17. ncbi Silylation-based kinetic resolution of monofunctional secondary alcohols
    Cody I Sheppard
    Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, GSRC 109, Columbia, South Carolina 29208, USA
    Org Lett 13:3794-7. 2011
    ..small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation...
  18. ncbi The frequency of occurrence of acyclic monoterpene alcohols in the chemical environment does not determine olfactory sensitivity in nonhuman primates
    Matthias Laska
    Department of Medical Psychology, University of Munich Medical School, Germany
    J Chem Ecol 32:1317-31. 2006
    ..of five spider monkeys, three squirrel monkeys, and three pigtail macaques for six acyclic monoterpene alcohols that differ markedly in their frequency of occurrence in plant odors was assessed...
  19. ncbi Metabolic engineering of Escherichia coli for biotechnological production of high-value organic acids and alcohols
    Chao Yu
    Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, China
    Appl Microbiol Biotechnol 89:573-83. 2011
    ..of high-value organic acids like succinic acid, lactic acid, 3-hydroxypropanoic acid and glucaric acid as well as alcohols like 1,3-propanediol, xylitol, mannitol, and glycerol with the discussion of the future research in this area...
  20. pmc Site-selective catalysis: toward a regiodivergent resolution of 1,2-diols
    Amanda D Worthy
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Am Chem Soc 134:7321-4. 2012
    ..The reaction has been parlayed into a divergent kinetic resolution on a racemic mixture, providing access to highly enantioenriched secondary-protected 1,2-diols in a single synthetic step...
  21. ncbi Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner
    Tomoko Komatsu
    Division of Cell Signaling, Okazaki Institute for Integrative Bioscience National Institute for Physiological Sciences, National Institutes of Natural Sciences, Higashiyama 5 1, Myodaiji, Okazaki, Aichi, Japan
    Pflugers Arch 463:549-59. 2012
    ..Here, we show that primary alcohols, which have been reported to cause skin, eye or nasal irritation, activate human TRPA1 (hTRPA1)...
  22. ncbi Effect of aliphatic alcohols on growth and degree of saturation of membrane lipids in Acinetobacter calcoaceticus
    Nadja Kabelitz
    Department of Remediation Research, Centre for Environmental Research UFZ Leipzig Halle, Permoserstr 15, 04318 Leipzig, Germany
    FEMS Microbiol Lett 220:223-7. 2003
    The adaptive responses of the bacterium Acinetobacter calcoaceticus to different aliphatic alcohols on the level of the membrane fatty acids were studied in detail...
  23. pmc Can intensive use of alcohol-based hand rubs lead to passive alcoholization?
    Vincent Bessonneau
    Environment and Health Research Laboratory, French School of Public Health, Rennes, France
    Int J Environ Res Public Health 7:3038-50. 2010
    Hand disinfection with alcohols-based hand rubs (ABHRs) are known to be the most effective measure to prevent nosocomial infections in healthcare. ABHRs contain on average 70% by weight of one or more alcohols...
  24. ncbi Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors
    Cecilia M Borghese
    University of Texas at Austin, Waggoner Center for Alcohol and Addiction Research, Austin, TX 78712 0159, USA
    J Pharmacol Exp Ther 307:42-52. 2003
    ..We studied different n-alcohols (ethanol, butanol, pentanol, and octanol), as well as isoflurane and urethane, on these two mutants...
  25. ncbi Composition and antimicrobial activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. essential oils and their major monoterpene alcohols alone and in combination
    Imaël Henri Nestor Bassolé
    Laboratoire BAEBIB, UFR SVT, Universite de Ouagadougou, 09 BP 848 Ouagadougou, Burkina Faso
    Molecules 15:7825-39. 2010
    ..x piperita and, linalool and eugenol for O. basilicum. The essential oils and their major monoterpene alcohols were tested against nine bacterial strains using the disc diffusion and broth microdilution methods...
  26. ncbi Efficient synthesis of optically pure alcohols by asymmetric hydrogen-transfer biocatalysis: application of engineered enzymes in a 2-propanol-water medium
    Nobuya Itoh
    Department of Biotechnology, Faculty of Engineering, Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Appl Microbiol Biotechnol 93:1075-85. 2012
    We describe an efficient method for producing both enantiomers of chiral alcohols by asymmetric hydrogen-transfer bioreduction of ketones in a 2-propanol (IPA)-water medium with E...
  27. ncbi Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers
    Hugh E Criswell
    Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, USA
    Brain Res 1015:107-13. 2004
    Volatile hydrocarbon based CNS depressants including short chain alcohols and anesthetics act, in part, by inhibition of the excitatory effect of glutamate at the NMDA receptor...
  28. ncbi Comprehensive gene expression analysis of the response to straight-chain alcohols in Saccharomyces cerevisiae using cDNA microarray
    K Fujita
    Japan Bioindustry Association JBA, Daicel Chemical Industries, Ltd, Branch, Tsukuba, Japan
    J Appl Microbiol 97:57-67. 2004
    The purpose of this study was to examine the gene expression profiles of yeast Saccharomyces cerevisiae subjected to straight-chain alcohols.
  29. ncbi Effects of prenatal alcohol exposure on hippocampal volume, verbal learning, and verbal and spatial recall in late childhood
    Karen A Willoughby
    Neuroscience and Mental Health Research Program, Hospital for Sick Children, Toronto, Ontario, Canada
    J Int Neuropsychol Soc 14:1022-33. 2008
    ....
  30. ncbi Clinical effectiveness of alcohol-based products in increasing hand hygiene compliance and reducing infection rates: a systematic review
    A Stout
    NHS Quality Improvement Scotland, Glasgow, UK
    J Hosp Infect 66:308-12. 2007
    ....
  31. ncbi Solvent polarity and organic reactivity in mixed solvents: evidence using a reactive molecular probe to assess the role of preferential solvation in aqueous alcohols
    T William Bentley
    Department of Chemistry, University of Wales, Swansea, Singleton Park, Swansea, SA2 8PP, Wales, United Kingdom
    J Org Chem 70:1647-53. 2005
    ..In contrast, another solvatochromic polarity index, E(T)(30), shows "dispersion" in correlations with the solvent ionizing power parameter, Y(OTs), probably due to aromatic ring and other solvation effects...
  32. ncbi Enzymatic synthesis of optically active tertiary alcohols: expanding the biocatalysis toolbox
    Robert Kourist
    Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, Greifswald University, Felix Hausdorff Strasse 4, 17487 Greifswald, Germany
    Chembiochem 9:491-8. 2008
    Enantiopure tertiary alcohols are very valuable building blocks for the synthesis of many different natural products and pharmaceuticals...
  33. ncbi Metabolic products and pathways of fluorotelomer alcohols in isolated rat hepatocytes
    Jonathan W Martin
    Graduate Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ont, Canada M5S 2S2
    Chem Biol Interact 155:165-80. 2005
    Fluorotelomer alcohols (FTOHs; CF(3)(CF(2))(x)C(2)H(4)OH; where x=3, 5, 7, 9) are a novel class of polyfluorinated contaminants, recently detected in the North American atmosphere, that are possible precursors to the series of ..
  34. ncbi Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile
    Nathalie Vernaz
    Pharmacy Department, University of Geneva Hospitals and Medical School, Geneva, Switzerland
    J Antimicrob Chemother 62:601-7. 2008
    ..The aim of this study was to determine the temporal relation between the use of antibiotics and alcohol-based hand rubs (ABHRs) and the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium difficile...
  35. ncbi Effectiveness of alcohol-based hand rubs for removal of Clostridium difficile spores from hands
    Umair Jabbar
    Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, USA
    Infect Control Hosp Epidemiol 31:565-70. 2010
    ..Alcohol is not effective against Clostridium difficile spores. We examined the retention of C. difficile spores on the hands of volunteers after ABHR use and the subsequent transfer of these spores through physical contact...
  36. pmc Novel haloperoxidase from the agaric basidiomycete Agrocybe aegerita oxidizes aryl alcohols and aldehydes
    René Ullrich
    Unit of Environmental Biotechnology, International Graduate School of Zittau, Markt 23, D 02763 Zittau, Germany
    Appl Environ Microbiol 70:4575-81. 2004
    ..a bark mulch- and wood-colonizing basidiomycete, was found to produce a peroxidase (AaP) that oxidizes aryl alcohols, such as veratryl and benzyl alcohols, into the corresponding aldehydes and then into benzoic acids...
  37. pmc The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers
    Hung V Ly
    Department of Chemical Engineering and Material Science, University of California, Davis, California, USA
    Biophys J 87:1013-33. 2004
    ..phase 1-stearoyl, 2-oleoyl phosphatidylcholine (SOPC) lipid bilayers exposed to aqueous solutions of short-chain alcohols at alcohol concentrations ranging from 0.1 to 9.8 M...
  38. ncbi Orchestration of concurrent oxidation and reduction cycles for stereoinversion and deracemisation of sec-alcohols
    Constance V Voss
    Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, A 8010 Graz, Austria
    J Am Chem Soc 130:13969-72. 2008
    ..cycles can be run in opposing directions beside each other enabling one-pot transformation of racemic alcohols to one enantiomer via concurrent enantioselective oxidation and asymmetric reduction employing defined alcohol ..
  39. ncbi Amyloid formation in surfactants and alcohols: membrane mimetics or structural switchers?
    Daniel E Otzen
    Interdisciplinary Nanoscience Center iNANO, Department of Molecular Biology, Aarhus University, Gustav Wieds Vej 10C, DK 8000, Denmark
    Curr Protein Pept Sci 11:355-71. 2010
    ..While both anionic surfactants such as SDS and fluorinated alcohols such as TFE are often championed as membrane mimics in one way or another, it is probably fair to say that their ..
  40. pmc Inhibition of chlamydiae by primary alcohols correlates with the strain-specific complement of plasticity zone phospholipase D genes
    David E Nelson
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA
    Infect Immun 74:73-80. 2006
    ..that strains of chlamydiae encoding the pzPLD, but not a strain lacking these genes, are inhibited by primary alcohols, potent PLD inhibitors, during growth in HeLa 229 cells...
  41. ncbi The generalization of an olfactory-based conditioned response reveals unique but overlapping odour representations in the moth Manduca sexta
    K C Daly
    Department of Entomology, Ohio State University, Columbus, OH 43210 1220, USA
    J Exp Biol 204:3085-95. 2001
    ..When moths were conditioned to 2-hexanone or 1-decanol and tested with a number of alcohols and ketones, we found that the generalization of the conditioned response decreased as a function of the chain ..
  42. ncbi Alcoholism in cockchafers: orientation of male Melolontha melolontha towards green leaf alcohols
    Andreas Reinecke
    Institut fur Biologie, Angewandte Zoologie Okologie der Tiere, Freie Universitat Berlin, Germany
    Naturwissenschaften 89:265-9. 2002
    ..Funnel trap field bioassays revealed that green leaf alcohols (i.e...
  43. ncbi Biotransformation of hop-derived monoterpene alcohols by lager yeast and their contribution to the flavor of hopped beer
    Kiyoshi Takoi
    Value Creation Department, Sapporo Breweries Ltd, Yaizu, Shizuoka 425 0013, Japan
    J Agric Food Chem 58:5050-8. 2010
    ..Among these flavor compounds, terpenoids are mainly derived from hops. Linalool, one of the monoterpene alcohols, has been found in various beers and been regarded as an important factor for a hop-derived beer flavor...
  44. ncbi Self-diffusion of water and simple alcohols in single-walled aluminosilicate nanotubes
    Ji Zang
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332 0100, USA
    ACS Nano 3:1548-56. 2009
    ..D(s) values of water in an analogous aluminogermanate NT are larger than those in the aluminosilicate NT due to a larger pore diameter...
  45. pmc Composition of secondary alcohols, ketones, alkanediols, and ketols in Arabidopsis thaliana cuticular waxes
    Miao Wen
    Department of Chemistry, University of British Columbia, Vancouver, Canada
    J Exp Bot 60:1811-21. 2009
    ..containing secondary functional groups were examined (i) to test the biosynthetic relationship between secondary alcohols and ketols and (ii) to determine the regiospecificity and substrate preference of the enzyme involved in ketol ..
  46. ncbi Application of modified Mosher's method for primary alcohols with a methyl group at C2 position
    Masashi Tsuda
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Chem Pharm Bull (Tokyo) 51:448-51. 2003
    The absolute configurations of a series of primary alcohols possessing a branched methyl group at C2 position were examined on the basis of a modified Mosher's method proposed by Minale et al...
  47. ncbi Prediction of pKa values for aliphatic carboxylic acids and alcohols with empirical atomic charge descriptors
    Jinhua Zhang
    Computer Chemie Centrum and Institut für Organische Chemie, Universitat Erlangen Nurnberg, Nagelsbachstrasse 25, D 91052, Erlangen, Germany
    J Chem Inf Model 46:2256-66. 2006
    Two quantitative pKa prediction models for aliphatic carboxylic acids and for alcohols were developed by multiple linear-regression (MLR) analysis with empirical atomic descriptors...
  48. pmc Enantioselective redox-relay oxidative heck arylations of acyclic alkenyl alcohols using boronic acids
    Tian Sheng Mei
    Department of Chemistry, University of Utah, Salt Lake City, Utah 84112, United States
    J Am Chem Soc 135:6830-3. 2013
    ..A preliminary mechanistic investigation suggests that the regioselectivity of the initial migratory insertion is highly dependent on the electronic nature of the boronic acid and more subtle electronic effects of the alkenyl alcohol...
  49. ncbi Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution
    Nguyen T Huy
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan Venture Laboratory, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Acta Trop 101:130-8. 2007
    ..for beta-hematin formation, we systematically studied beta-hematin formation induced by a series of small normal alcohols (methanol, ethanol, n-propanol, and n-butanol), which are structurally similar...
  50. ncbi Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis
    Susan E Ownby
    Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Lipids 38:751-9. 2003
    ..In this study, we further characterize the manner in which these isoprenoid alcohols are utilized for protein isoprenylation...
  51. pmc How alcohol chain-length and concentration modulate hydrogen bond formation in a lipid bilayer
    Allison N Dickey
    Department of Chemical Engineering and Materials Science, University of California Davis, Davis, California 95616, USA
    Biophys J 92:2366-76. 2007
    ..This appears to be the result of the system being very near to a phase transition, and one occurrence of lipid flip-flop is seen at this concentration...
  52. ncbi Induction of suppressed ADH activity in Drosophila pachea exposed to different alcohols
    Edward Pfeiler
    Centro de Investigacion en Alimentacion y Desarrollo, A C, Unidad Guaymas, Guaymas, Sonora, Mexico
    Biochem Genet 41:413-26. 2003
    ..In the present study we examined the effectiveness of different alcohols and related compounds, including several found naturally in necroses of the host cactus, to induce suppressed ADH ..
  53. ncbi Molten-globule like partially folded states of human serum albumin induced by fluoro and alkyl alcohols at low pH
    Yogesh Kumar
    Interdisciplinary Biotechnology Unit, A M University, Aligarh 202 002, India
    Arch Biochem Biophys 426:3-10. 2004
    ..At pH 2.0, these alcohols induced the formation of alpha-helical structure as evident from the increase in mean residue ellipticity (MRE) ..
  54. ncbi Preparation of novel alumina nanowire solid-phase microextraction fiber coating for ultra-selective determination of volatile esters and alcohols from complicated food samples
    Zhuomin Zhang
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    J Chromatogr A 1290:27-35. 2013
    ..a simple and rapid anodization-chemical etching method for ultra-selective determination of volatile esters and alcohols from complicated food samples...
  55. ncbi Human exposure to fluorotelomer alcohols, perfluorooctane sulfonate and perfluorooctanoate via house dust in Bavaria, Germany
    Zhenlan Xu
    Helmholtz Center Munich National Research Center for Environmental Health, Molecular EXposomics MEX, Ingolstadter Landstr 1, Neuherberg 85764, Germany
    Sci Total Environ 443:485-90. 2013
    This study aimed at investigating the presence and distribution of fluorotelomer alcohols (FTOHs), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in house dust to evaluate human exposure to these compounds via dust ..
  56. ncbi Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols
    J Sturzebecher
    Zentrum fur Vaskulare Biologie und Medizin Erfurt, Friedrich Schiller Universitat Jena, Erfurt, Germany
    FEBS Lett 412:295-300. 1997
    ..We found that several alcohols dramatically enhance the catalytic activity of human FIXa towards synthetic substrates...
  57. ncbi Cytotoxic polyacetylenic alcohols from the marine sponge Petrosia species
    Y J Lim
    College of Pharmacy, Pusan National University, Pusan 609-735, Korea
    J Nat Prod 64:1565-7. 2001
    New polyacetylenic alcohols (1-5) have been isolated as cytotoxic principles from the marine sponge Petrosia sp. The compounds were particularly cytotoxic against a human melanoma cell line (SK-MEL-2)...
  58. pmc N-heterocyclic carbene-catalyzed conjugate additions of alcohols
    Eric M Phillips
    Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, Silverman Hall, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    J Am Chem Soc 132:13179-81. 2010
    An efficient intermolecular conjugate addition of alcohols to activated alkenes catalyzed by N-heterocyclic carbenes has been developed...
  59. ncbi The promoting effect of adsorbed carbon monoxide on the oxidation of alcohols on a gold catalyst
    Paramaconi Rodriguez
    Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    Nat Chem 4:177-82. 2012
    ..adsorbed carbon monoxide typically acts as a poison or poisoning intermediate in the oxidation of alcohols. However, gold as an (electro)catalyst often exhibits unexpected properties...
  60. ncbi The antifungal activity of the cuticular and internal fatty acid methyl esters and alcohols in Calliphora vomitoria
    Marek Gołębiowski
    Faculty of Chemistry, Institute for Environmental and Human Health Protection, University of Gdansk, ul Sobieskiego 18 19, 80 952 Gdansk, Poland
    Parasitology 140:972-85. 2013
    ..Seven FAMEs from C13:0 to C19:0 were identified in the internal lipids of females, and 7, 6, 5 and 3 alcohols were found in the cuticular lipids of larvae, pupae, males and females respectively...
  61. ncbi Hydrogen evolution from aliphatic alcohols and 1,4-selective hydrogenation of NAD+ catalyzed by a [C,N] and a [C,C] cyclometalated organoiridium complex at room temperature in water
    Yuta Maenaka
    Department of Material and Life Science, Graduate School of Engineering, Osaka University, ALCA, Japan Science and Technology Agency, Suita, Japan
    J Am Chem Soc 134:9417-27. 2012
    ..acid-κC(3))(H(2)O)](2)SO(4) [1](2)·SO(4), was reduced by aliphatic alcohols to produce the corresponding hydride complex [Ir(III)(Cp*)(4-(1H-pyrazol-1-yl-κN(2))-benzoate-κC(3))H](-)4 at ..
  62. ncbi UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers
    M P Bernstein
    NASA Ames Research Center, Mail Stop 245 6, Moffett Field, CA 94035 1000, USA
    Science 283:1135-8. 1999
    ..Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account ..
  63. pmc Allylation of nitrosobenzene with pinacol allylboronates. A regioselective complement to peroxide oxidation
    Robert E Kyne
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    Org Lett 12:3796-9. 2010
    ..Remarkably, the N-O bond is cleaved during the reaction such that simple alcohols are the final reaction product.
  64. ncbi Visible-light-mediated conversion of alcohols to halides
    Chunhui Dai
    Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA
    Nat Chem 3:140-5. 2011
    ..Here, we report a visible-light-mediated photocatalytic alcohol activation, which we use to convert alcohols to the corresponding bromides and iodides in good yields, with exceptional functional group tolerance...
  65. pmc Effectiveness of alcohol-based hand disinfectants in a public administration: impact on health and work performance related to acute respiratory symptoms and diarrhoea
    Nils Olaf Hübner
    Institute of Hygiene and Environmental Medicine, Walter Rathenau Strasse 49 A 17487 Greifswald, Germany
    BMC Infect Dis 10:250. 2010
    ..Hand disinfection is acknowledged as key element for infection control, but its effect in open, work place settings is unclear...
  66. ncbi Efficient ruthenium-catalyzed aerobic oxidation of alcohols using a biomimetic coupled catalytic system
    Gabor Csjernyik
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm Sweden
    J Org Chem 67:1657-62. 2002
    Efficient aerobic oxidation of alcohols was developed via a biomimetic catalytic system...
  67. pmc Dansylation of unactivated alcohols for improved mass spectral sensitivity and application to analysis of cytochrome P450 oxidation products in tissue extracts
    Zhongmei Tang
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, Tennessee 37232 0146, USA
    Anal Chem 82:7706-12. 2010
    ..for fluorescence detection and for facilitating the MS detection of phenols and amines, but not for general alcohols. A new dansylation method for improving the mass spectral sensitivity of unactivated alcohols was developed...
  68. ncbi Quantitative structure-fungitoxicity relationships of some monohydric alcohols
    Eugene Sebastian J Nidiry
    Indian Institute of Horticultural Research, Hessaraghatta Lake P O, Bangalore 560 089, India
    J Agric Food Chem 51:5337-43. 2003
    The fungitoxicity data of some monohydric alcohols on the mycelial growth inhibition of Colletotrichum gloeosporioides were subjected to quantitative structure-activity relationship (QSAR) studies...
  69. ncbi 2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2
    Danielle K Neff
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 17:6467-71. 2007
    ..These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility...
  70. ncbi Lipase-catalyzed highly enantioselective kinetic resolution of boron-containing chiral alcohols
    Leandro H Andrade
    Institute of Chemistry, University of Sao Paulo, Av Prof Lineu Prestes, 748, CEP 05508 900, Sao Paulo, SP, Brazil
    Org Lett 11:3052-5. 2009
    ..The kinetic resolution of boron-containing chiral alcohols via enantioselective transesterification catalyzed by lipases was studied...
  71. ncbi Influence of the structure of polyfluorinated alcohols on Brønsted acidity/hydrogen-bond donor ability and consequences on the promoter effect
    Daniela Vuluga
    Laboratoire BioCIS CNRS, Faculté de Pharmacie, Univ Paris Sud, 5 rue Jean Baptiste Clément, F 92296 Châtenay Malabry, France
    J Org Chem 76:1126-33. 2011
    The influence of substituents on the properties of tri- and hexafluorinated alcohols derived from 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was examined...
  72. ncbi Structure of a novel enzyme that catalyzes acyl transfer to alcohols in aqueous conditions
    Irimpan Mathews
    Stanford Synchrotron Research Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA
    Biochemistry 46:8969-79. 2007
    ..These properties create an environment by which MsAcT can catalyze transesterification reactions in an aqueous medium and suggests how a serine hydrolase can be engineered to be an efficient acyltransferase...
  73. ncbi An improved Cu-based catalyst system for the reactions of alcohols with aryl halides
    Ryan A Altman
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Org Chem 73:284-6. 2008
    ..reactions of aryl iodides and bromides with primary and secondary aliphatic, benzylic, allylic, and propargylic alcohols. Most importantly, by employing this catalyst system, the need to use an excessive quantity of the alcohol ..
  74. ncbi Unfolding action of alcohols on a highly negatively charged state of cytochrome C
    Pulikallu Sashi
    School of Chemistry, University of Hyderabad, Hyderabad 500 046, India
    Biochemistry 51:3273-83. 2012
    ..Studies with extremely alkaline cytochrome c (U(B) state, pH 13) in the presence of the first four alkyl alcohols suggests that the hydrophobic effect persistently overrides even though the protein carries a net charge of -17 ..
  75. ncbi XTT assay for evaluating the effect of alcohols, hydrogen peroxide and benzalkonium chloride on biofilm formation of Staphylococcus epidermidis
    Kamel Chaieb
    Laboratoire d Analyses, Traitement et Valorisation des Polluants de l Environnement et des Produits, Faculte de Pharmacie, Rue Avicenne 5000 Monastir, Tunisia
    Microb Pathog 50:1-5. 2011
    ..This study suggests that some biocides currently used in hospitals are ineffective against nosocomial pathogens growing in biofilms when used at weak concentration and fail to control this reservoir for hospital-acquired infection...
  76. ncbi Solubility of lovastatin in a family of six alcohols: Ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, and 1-octanol
    J Nti-Gyabaah
    Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, NJ 08854 8058, United States
    Int J Pharm 359:111-7. 2008
    ..The order of increasing ideality, or solubility of lovastatin was butanol>1-propanol>1-pentanol>1-hexanol>1-octanol...
  77. ncbi 2-azaadamantane N-oxyl (AZADO) and 1-Me-AZADO: highly efficient organocatalysts for oxidation of alcohols
    Masatoshi Shibuya
    Department of Organic Chemistry and Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980 8578, Japan
    J Am Chem Soc 128:8412-3. 2006
    ..radical class of catalysts, 2-azaadamantane N-oxyl (AZADO) and 1-Me-AZADO, for highly efficient oxidation of alcohols is described...
  78. ncbi Palladium catalysts for aerobic oxidative kinetic resolution of secondary alcohols based on mechanistic insight
    David R Jensen
    Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Org Lett 5:63-5. 2003
    The oxidative kinetic resolution of secondary alcohols has been accomplished using 1:1 complexes of PdCl(2) and N-heterocyclic carbenes...
  79. ncbi Dehydration from alcohols by polyion complex cross-linked chitosan composite membranes during evapomeation
    Tadashi Uragami
    Faculty of Engineering and High Technology Research Center, Kansai University, Suita, Osaka 564 8680, Japan
    Biomacromolecules 4:137-44. 2003
    ..The above results were discussed from the viewpoint of the physical and chemical structure of the q-Chito-PEO acid polyion complex/PES composite membranes and the permeants...
  80. ncbi Locomotor activity responses to ethanol, other alcohols, and GABA-A acting compounds in forward- and reverse-selected FAST and SLOW mouse lines
    Abraham A Palmer
    Portland Alcohol Research Center, Portland, Oregon, USA
    Behav Neurosci 116:958-67. 2002
    ..Results support an effect of selection for ethanol sensitivity on allosteric modulation of the GABA-A receptor...
  81. ncbi Chemical syntheses of caffeoyl and 5-OH coniferyl aldehydes and alcohols and determination of lignin O-methyltransferase activities in dicot and monocot species
    F Chen
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Phytochemistry 58:1035-42. 2001
    ..The same procedure can also be used to synthesize caffeoyl and 5-hydroxyconiferyl alcohols. Relative O-methyltransferase activities against these substrates were determined using crude extracts and ..
  82. ncbi Oxidation of alcohols with molecular oxygen on solid catalysts
    Tamas Mallat
    Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, ETH Honggerberg, HCI, CH 8093 Zurich, Switzerland
    Chem Rev 104:3037-58. 2004
  83. ncbi Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols
    Valerie C Robinson
    Cosmetic Ingredient Review, Washington, DC 20036, USA
    Int J Toxicol 29:151S-61S. 2010
    Sodium laureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics...
  84. pmc Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells
    Zhao Lu
    Department of Internal Medicine, Section of Digestive Diseases, and Cell Biology, Veterans Administration Connecticut Healthcare, West Haven 06516, USA
    Am J Physiol Gastrointest Liver Physiol 282:G501-7. 2002
    ..The effects of ethanol were concentration dependent. Alcohols with a chain length of >or=2 also sensitized the acinar cell to caerulein; the most potent was butanol...
  85. ncbi Characterization of a partially folded intermediate of papain induced by fluorinated alcohols at low pH
    Aabgeena Naeem
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    Arch Biochem Biophys 432:79-87. 2004
    ..Temperature-induced unfolding of HFIP and TFE-induced state was weakly cooperative in comparison to cooperative transition of native...
  86. ncbi Toxicity of short-chain alcohols to the nematode Caenorhabditis elegans: a comparison of endpoints
    Grace Thompson
    Institute of Genetics, School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    J Biochem Mol Toxicol 19:87-95. 2005
    The toxicities of 4 short-chain alcohols--namely methanol, ethanol, iso-propanol and iso-butanol--were compared in the nematode Caenorhabditis elegans using several different ecotoxicological endpoints...
  87. ncbi Template-based modeling of a psychrophilic lipase: conformational changes, novel structural features and its application in predicting the enantioselectivity of lipase catalyzed transesterification of secondary alcohols
    Tao Xu
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China
    Biochim Biophys Acta 1804:2183-90. 2010
    ..However, only the lid-open conformational model could led to predictions that agreed with the following the experimental result of real biocatalysis reaction of 1-phenylethanol...
  88. pmc Alcohols for skin antisepsis at clinically relevant skin sites
    Mirja Reichel
    BODE Chemie GmbH, Scientific Affairs, Melanchthonstr 27, 22525 Hamburg, Germany
    Antimicrob Agents Chemother 53:4778-82. 2009
    ..Further studies are needed to determine the most effective concentration of CHG in n-propanol to provide the best protection against recolonization of the skin, e.g., for catheter site care...
  89. ncbi Quantitation of gas-phase perfluoroalkyl surfactants and fluorotelomer alcohols released from nonstick cookware and microwave popcorn bags
    Ewan Sinclair
    Wadsworth Center, New York State Department of Health, USA
    Environ Sci Technol 41:1180-5. 2007
    ..this study, we identified and measured perfluoroalkyl carboxylates (PFCAs), particularly PFOA, and fluorotelomer alcohols (FTOHs; 6:2 FTOH and 8:2 FTOH), released from nonstick cookware into the gas phase under normal cooking ..
  90. ncbi Influence of delta-functional groups on the enantiorecognition of secondary alcohols by Candida antarctica lipase B
    Jonas Nyhlén
    Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden
    Chembiochem 9:1968-74. 2008
    The selectivity of acetylation of delta-functionalized secondary alcohols catalyzed by Candida antarctica lipase B has been examined by molecular dynamics...
  91. pmc Photodegradation of 2-chloro substituted phenothiazines in alcohols
    CARMELO GARCIA
    Department of Chemistry, Humacao Campus, University of Puerto Rico, Humacao, Puerto Rico
    Photochem Photobiol 85:160-70. 2009
    ..phenothiazines and their phototoxic activity, their photophysics and photochemistry were studied in several alcohols. The photodestruction quantum yields were determined under anaerobic conditions using monochromatic light (313 nm)..
  92. ncbi Highly active, immobilized ruthenium catalysts for oxidation of alcohols to aldehydes and ketones. Preparation and use in both batch and flow systems
    Shu Kobayashi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency JST, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Chem Soc 127:9251-4. 2005
    A novel, highly active immobilized ruthenium catalyst, which can be successfully used in oxidation of alcohols to aldehydes and ketones, has been developed...
  93. pmc Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols
    Cecilia M Borghese
    Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712 0159, USA
    J Pharmacol Exp Ther 340:304-16. 2012
    ..The behavioral characterization of these knockin mice is presented in a companion article (J Pharmacol Exp Ther 340:317-329, 2012)...
  94. ncbi Differential scanning calorimetric studies on the thermal unfolding of Pseudomonas cepacia lipase in the absence and presence of alcohols
    A Tanaka
    Laboratory of Molecular Bioinformatics, Faculty of Bioresources, Mie University, Tsu
    J Biochem 123:289-93. 1998
    ..In the presence of 1-5% alcohols (methanol, ethanol, n-propanol, and n-butanol), tp decreased with increasing alcohol concentration and longer ..
  95. ncbi A computational model relating structure and reactivity in enantioselective oxidations of secondary alcohols by (-)-sparteine-Pd(II) complexes
    Robert J Nielsen
    Materials and Process Simulation Center, Beckman Institute 139 74, and The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 126:7967-74. 2004
    ..of (-)-sparteine-PdX(2) complexes (X = chloride, acetate) in the enantioselective oxidation of secondary alcohols have been elucidated using quantum mechanics (B3LYP DFT with the PBF polarizable continuum solvent model)...
  96. pmc Formation of alkenes via degradation of tert-alkyl ethers and alcohols by Aquincola tertiaricarbonis L108 and Methylibium spp
    Franziska Schäfer
    Department of Environmental Microbiology, Helmholtz Centre for Environmental Research UFZ, Permoserstr 15, 04318 Leipzig, Germany
    Appl Environ Microbiol 77:5981-7. 2011
    ..The possible use of alkene formation as an easy-to-measure indicator of aerobic fuel oxygenate biodegradation in contaminated aquifers is discussed...
  97. ncbi Effective, selective hydroalkoxylation/cyclization of alkynyl and allenyl alcohols mediated by lanthanide catalysts
    Xianghua Yu
    Department of Chemistry, Northwestern University, Evanston, Illinois 60208, USA
    J Am Chem Soc 129:7244-5. 2007
  98. ncbi Alcohols, esters and heavy sulphur compounds production by pure and mixed cultures of apiculate wine yeasts
    Nathalie Moreira
    Escola Superior de Biotecnologia, Universidade Catolica Portuguesa, Rua Dr Antonio Bernardino de Almeida, 4200 072 Porto, Portugal
    Int J Food Microbiol 103:285-94. 2005
    ..cerevisiae; however, growth of apiculate yeasts increased methionol contents of fermented media...
  99. ncbi Structural influence of mono and polyhydric alcohols on the stabilization of collagen
    R Usha
    Biophysics Laboratory, Central Leather Research Institute, Adyar, Chennai 600020, India
    Colloids Surf B Biointerfaces 48:101-5. 2006
    ..of the protein have been analyzed after equilibration with aqueous solutions of monohydric and polyhydric alcohols like methanol, ethanol, n-propanol, propane-2-diol and glycerol...
  100. ncbi Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia
    M Covarrubias
    Department of Pathology, Anatomy, and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 270:19408-16. 1995
    ..The results showed that: (i) these alcohols inhibited Shaw2 whole-cell currents, the equilibrium dose-inhibition relations were hyperbolic, and competition ..
  101. ncbi Structure determination of germacrane-type sesquiterpene alcohols from an endophyte Streptomyces griseus subsp
    Shuhong Guan
    School of Pharmaceutical Sciences, Peking University, Beijing 100083, P R China
    Magn Reson Chem 43:1028-31. 2005
    Three germacrane-type sesquiterpene alcohols were isolated from an endophyte of mangrove plant Kandelia candel...

Research Grants66

  1. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..was shown that these sites did not participate in the modulation of GlyRs by propofol, isoflurane and long chain alcohols indicating a novel and selective new site for ethanol...
  2. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
    ..novel oxygenases will be investigated that play key roles in the metabolic conversion of terpene hydrocarbons and alcohols to biosynthetic end-products...
  3. Atherogenic mechanism of lipid peroxidation-derived aldehydes
    Sanjay Srivastava; Fiscal Year: 2013
    ..macrophage specific overexpression or deletion of aldose reductase, which converts toxic aldehydes to innocuous alcohols, affects their atherogenic effects...
  4. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..In particular, we have identified a class of compounds (i.e. aliphatic ?-nitro alcohols = BNAs) that appear to be safe and effective as tissue cross-linking agents under conditions of physiologic pH ..
  5. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..Meanwhile, new chiral amino alcohols and diamines for N-acyl glycine and ethanolamide mimetics as well as their libraries will be synthesized...
  6. Role of Protein Kinase C regulatory domains in modulating alcohol actions
    Joydip Das; Fiscal Year: 2010
    ..The objective of this proposal is to define the molecular mechanisms by which alcohols exert their action on intracellular signal transduction pathways in brain...
  7. The Molecular Basis of Alcohol's Actions
    DAVID NIGEL JONES; Fiscal Year: 2010
    ..This may allow future development of novel approaches to prevent alcohols actions, and the identification of genetic markers associated with a predisposition to alcoholism.
  8. ARYL AND ALCOHOL SULFOTRANSFERASES IN DRUG METABOLISM
    Michael W Duffel; Fiscal Year: 2010
    ..metabolic formation of cytotoxic, mutagenic and/or carcinogenic molecules from xenobiotics that include benzylic alcohols derived from alkyl-substituted polycyclic aromatic hydrocarbons, hydroxylamine metabolites of aromatic amines and ..
  9. CRCNS: Alcohol modulation of dopamine-GABA dynamics in the ventral tegmental area
    Alexey S Kuznetsov; Fiscal Year: 2013
    ..An understanding of alcohols pharmacological and physiological effects on the DA system are improving, but understanding the specific ..
  10. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative
    JOHN J BOWSER; Fiscal Year: 2013
    ..Therefore, from a chemical stability standpoint, it can be operated with alcohols, organic acids, ketones, amines and aprotic solvents, to name a few...
  11. Low Temperature Solid-State NMR Technologies for Protein Structure Determination
    Chad M Rienstra; Fiscal Year: 2013
    ..Resolution will be enhanced by sparse isotopic labeling patterns and cryoprotection procedures utilizing organic alcohols, glycols and salts...
  12. Innovation in the Prevention and Treatment of Early Childhood Caries
    Norman Tinanoff; Fiscal Year: 2013
    ..of "at risk" children;success of self-management/behavorial change approaches;effect of antimicrobials (sugar alcohols, heavy metal, antiseptics) and remineralizing agents (fluoride, calcium phosphates, therapeutic restorative ..
  13. Structural analysis of alcohol-dependent activation of GIRKs
    Paul A Slesinger; Fiscal Year: 2013
    ..Recently, we showed with high-resolution structural studies that alcohols bind directly to hydrophobic pockets of inwardly rectifying potassium channels...
  14. Catalytic Aerobic Oxidations for Pharmaceutical Synthesis: Flow-Reaction Methods
    Shannon S Stahl; Fiscal Year: 2010
    ..transformations that build upon flow-based aerobic alcohol oxidations: (1) convergence of racemic secondary alcohols into their enantiomerically pure form via sequential aerobic alcohol oxidation/enantioselective ketone ..
  15. A Breath-based Naltrexone Adherence Tool to Manage Narcotic-addicted HIV patients
    DONN MICHAEL DENNIS; Fiscal Year: 2012
    ..Notable development findings include: 1) secondary (2o) alcohols (e.g...
  16. Design, Synthesis and Evaluation of Radical-Based Catalysts for the Direct Anti-M
    JEFFREY SCOTT CANNON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Primary alcohols are important molecules in both the commodity and pharmaceutical chemical industries...
  17. Aerobic Oxidative Functionalization of Alkenes: Methods and Mechanisms
    Shannon S Stahl; Fiscal Year: 2013
    ..synthesis of nitrogen heterocycles and for the modular coupling of primary amines with allylic amines or allylic alcohols enroute to versatile vicinial diamine and aminoalcohol products...
  18. Remote Blood Alcohol Analyzer
    KANG BIN CHUA; Fiscal Year: 2010
    ..analyzer compatible with a magnetic resonance environment such as functional magnetic resonance imaging to continuously monitor blood alcohol concentration and thus facilitate better understanding of alcohols effects on the brain.
  19. New Catalytic Systems for Stereoselective C-H Amination
    X Peter Zhang; Fiscal Year: 2013
    ..advance the enantioselective C-H amination reactions for stereoselective synthesis of valuable diamines and amino alcohols. These new catalytic methods will be applied to the stereoselective synthesis of biologically and ..
  20. Synthetic Methodology to Access Novel Antivirals
    Mahesh K Lakshman; Fiscal Year: 2012
    ..The chemistry relies on easily available or prepared alcohols and can be readily applied to chiral alcohols without loss of chirality...
  21. Development of New Catalytic and Enantioselective Reactions
    Marc L Snapper; Fiscal Year: 2013
    ..a large assortment of biologically active and medicinally relevant molecules are enantiomerically pure amines and alcohols. Although enantioselective syntheses of these two important classes of molecules have benefited from recent ..
  22. Catalytic Methods for Carbon-Carbon and Carbon-Heteroatom Bond Formation
    F D Toste; Fiscal Year: 2013
    ..reactions catalyzed by chiral gold complexes or Bronsted acids generated by coordination of protic species (alcohols) to chiral gold-complexes will be examined...
  23. Rhodium-Catalyzed 1,2-Addition of Pinacolboronic Esters into Ketones
    GARY MICHAEL GALLEGO; Fiscal Year: 2013
    ..of this investigation, an asymmetric variant will be developed allowing access to enantio-enriched tertiary alcohols. Preliminary results have shown aromatic and heteroaromatic pinacolboronic esters have undergo 1,2-addition into ..
  24. Development of Catalysts for Asymmetric Synthesis
    VIRESH RAWAL; Fiscal Year: 2009
    ..The research is divided into two primary areas: catalysis by chiral alcohols and catalysis by chiral squaramides and other novel hydrogen bond donor scaffolds...
  25. ROLE OF PROLONGED REPOLARIZATION IN CARDIAC ARRHYTHMIAS
    Dan Roden; Fiscal Year: 1992
    ..g. digitalis) and Cao, drugs (quinidine, amiodarone) and medium chain alcohols. We have implemented a computer model of porpagating Purkinje and ventricular muscle action potentials liked with ..
  26. REDOX GLYCOSIDATION
    ANTHONY BARRETT; Fiscal Year: 1992
    ..Two distinct procedures will be investigated. Aldonic acids will be esterified with carbohydrate alcohols. Subsequent methylenylation and iodoetherification will be used to prepare oligosaccharides containing the aldose-..
  27. GPx-3, Vascular Oxidant Stress, and Thrombosis
    Joseph Loscalzo; Fiscal Year: 2006
    ..peroxidase is a selenocysteine-containing enzyme that reduces hydrogen and lipid peroxides to their corresponding alcohols, and does so using either glutathione or thioredoxin as reducing equivalents...
  28. AROMATIC AMINE LOCAL ANESTHETICS AND MEMBRANES
    Issaku Ueda; Fiscal Year: 1990
    ..Nevertheless, atypical local anesthetics, such as alcohols, tranquilizers, antihistaminics, barbiturates, narcotics, general anesthetics, etc., also block nerve conduction...
  29. SPHINGOLIPIDS AND STEROLS--METABOLISM AND INTERACTIONS
    Seiichi Matsuda; Fiscal Year: 2000
    ..the biochemistry, chemistry, and actions of sterols, sphingolipid bases (and their derivatives), and isoprenoid alcohols and acids as well as potential interrelationships in their metabolism and actions...
  30. New Reactions for Heterocycle Synthesis
    John P Wolfe; Fiscal Year: 2010
    ..can be used for the preparation of important classes of compounds including pyrrolidines, tetrahydrofurans, amino alcohols, diols, and diamines...
  31. Alcohol actions on NMDA receptor gating domains
    ROBERT WILLIAM PEOPLES; Fiscal Year: 2013
    ..gating, and that these sites, and the specific mechanism of inhibition, differ among NR2 subunits and different alcohols. These studies will provide the most complete information to date on the mechanism of alcohol action on the NMDA ..
  32. Catalytic C-C Bond Forming Hydrogenations.
    Michael J Krische; Fiscal Year: 2013
    ..Here, using ruthenium or iridium catalysts, alcohols serve dually as hydrogen donors and aldehyde precursors, enabling carbonyl addition directly from the alcohol ..
  33. Refining &Implementing Supramolecular Methods for HTS of EE &Concentration
    Eric V Anslyn; Fiscal Year: 2013
    ..operational (primary amines, carboxylic acids, and ketones), and we will devise an assay for chiral secondary alcohols. Second, to implement our assays in real life settings we have established three collaborations with synthetic ..
  34. NEW CYCLIZATION METHODS AND MULTICOMPONENT COUPLINGS
    John Montgomery; Fiscal Year: 2013
    ..This outcome will be broadly significant since allylic alcohols are an integral feature in many bioactive compounds and serve as versatile building blocks for a wide range of ..
  35. Ichthyosis in Sjogren-Larsson Syndrome
    William B Rizzo; Fiscal Year: 2010
    ..and are hypothesized to arise from the deranged metabolism of fatty aldehydes and precursor lipids such as fatty alcohols, which cannot be metabolized by FALDH...
  36. Catalytic Asymmetric Hydrogenation
    Xumu Zhang; Fiscal Year: 2007
    ..this proposal are: 1) to develop novel transition metal reduction catalysts for the practical synthesis of chiral alcohols, amines, acids, amino alcohols, diols, alpha and beta-amino acids; 2) to understand the fundamental factors ..
  37. Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme
    Ning Shangguan; Fiscal Year: 2011
    ..Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and nitrations of aromatic ..
  38. Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme
    Ning Shangguan; Fiscal Year: 2012
    ..Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and nitrations of aromatic ..
  39. Evolving Inproved Formate Dehydrogenases
    JAMES ROZZELL; Fiscal Year: 2005
    ..processes using amino acid dehydrogenases and alcohol dehydrogenases to make non-natural amino acids and chiral alcohols, the demands for ever more efficient and cost-effective methods for nicotinamide cofactor are increasing...
  40. ALCOHOL AND CELL ADHESION
    MICHAEL EDWARD CHARNESS; Fiscal Year: 2010
    ..Structure activity analysis of a series of straight and branch-chain alcohols demonstrates remarkable structural specificity for alcohol inhibition of cell-cell adhesion...
  41. New Methods for Nitrogen Heterocycle Synthesis
    Sherry R Chemler; Fiscal Year: 2013
    ..The starting compounds are stable, readily available amines, alcohols and alkenes...
  42. Practical Strategies for Controlling Selectivity in Organic Reactions
    Amir H Hoveyda; Fiscal Year: 2013
    ..ability to simultaneously and reversibly bind to a metal catalyst and common organic functional groups (such as alcohols, amines, and carboxylic acids)...
  43. Group (IV) Imido Complex-Mediated Syntheses of Nitrogen-Containing Heterocycles
    JENNIFER SCHOMAKER; Fiscal Year: 2009
    ..The proposed study builds on this chemistry to access aziridines, vicinal amino alcohols, enamides, ynamides and pyrrolidines that are important compounds in their own right, but also serve as ..
  44. SELECTIVE ANESTHETIC ACTIONS ON NMDA RECEPTORS
    Hugh Criswell; Fiscal Year: 2002
    ..Recent work by our laboratory and others has shown that both volatile anesthetics and n-alcohols have differing effects on NMDA-receptor function depending on the brain area studied...
  45. Stereoselective Rearrangements for the Synthesis of Bioactive Small Molecules
    UTTAM KRISHAN TAMBAR; Fiscal Year: 2013
    ..1: Metal-Catalyzed Enantioselective Allylic Amination Specific Aim A.1: Stereoselective Synthesis of Amino alcohols and Selectively Protected Monosaccharides B...
  46. Total Synthesis of Cytotoxic ent-Kauranoid Natural Products
    DAVID JOHN MICHAELIS; Fiscal Year: 2012
    ..research plan will focus on the development of a novel vanadium-catalyzed cascade reaction between propargylic alcohols and cyclopropyl aldehydes that generates highly functionalized 1,3-dienes...
  47. Photolabeling of alcohol binding sites L1:
    Keith Miller; Fiscal Year: 2005
    ..Different alcohols show remarkable structural specificity for alcohol inhibition of cell adhesion (agonist action)...
  48. LC/MS of Large Atherogenic Lipid Oxidation Products
    WILLIAM BYRDWELL; Fiscal Year: 2003
    ..products that contain fatty acids with multiple functional groups, such as hydroperoxides, epoxides, ketones and alcohols. Fatty acid oxidation products have been shown to represent a significant atherosclerotic risk...
  49. PHOSPHOLIPASE D AND KERATINOCYTE DIFFERENTIATION
    Wendy Bollag; Fiscal Year: 2007
    ..However, PLD can also catalyze a transphosphatidylation reaction, in the presence of small amounts of primary alcohols, to generate phosphatidylalcohols...
  50. METHOD FOR MAKING AN IMPROVED ST JOHN'S WORT PRODUCT
    TREVOR CASTOR; Fiscal Year: 2001
    ..involves the use of supercritical fluids and near-critical fluids with and without polar cosolvents such as alcohols (trademarked as SuperFluids)...
  51. NICOTINIC RECEPTOR SITES FOR ALCOHOL ACTIONS
    Stuart Forman; Fiscal Year: 2000
    ..long term objective of the proposed research is to define the molecular mechanisms whereby ethanol and long chain alcohols act at neurotransmitter gated ion channels in the brain...
  52. NORMAL SKIN LIPID METABOLISM & CORNIFICATION DISORDERS
    Mary Williams; Fiscal Year: 1992
    ..These studies are based upon the hypothesis that epidermis synthesizes alkanes from fatty acids or alcohols; that changes in the number or function of peroxisomes, a cellular organelle involved in fatty alcohol and v.l.c...
  53. Reproductive Outcomes in Salon Employees (ROSE)
    Jodi Flaws; Fiscal Year: 2007
    ..are exposed to a variety of chemicals on a daily basis, including bleaches, hair dyes, non-lye relaxers, alcohols, methacrylate, ethylene glycol, and pthalates...
  54. NMR Investigations of the Site of Anesthetic Action
    HOLLY GAEDE; Fiscal Year: 2001
    ..action is unclear, partly because a wide range of chemical compounds induce anesthesia, including rare gas atoms, alcohols, and steroids. However, it is known that anesthetic potency correlates with lipophilicity...
  55. SYNTHESIS OF BIOLOGICAL ACTIVE AMINES, AMINOALCOHOLS
    Margarita Ortiz Marciales; Fiscal Year: 1999
    ..Chiral amines, amino alcohols and amino acids are important organic compounds used as building blocks for the synthesis of many pharmaceutical ..
  56. Syntesis of Polypropionate Antibiotics Via Epoxide Chemistry
    Jose A Prieto; Fiscal Year: 2013
    ..is a simple and reiterative one, and is based on the stereoselective epoxidation of homoallylic or allylic alcohols followed by their cleavage using organoalane or alanate, or alkenyl Grignard chemistry...
  57. Optimizing Escherichia coli for Carbonyl Reductions
    JAMES ROZZELL; Fiscal Year: 2007
    ..Chiral alcohols are ubiquitous intermediates in the synthesis of chiral drugs, and the stereoselective reduction of ketones is ..
  58. Catalytic Hydrofunctionalization as a Route to Heterocyclic Compounds
    ROSS WIDENHOEFER; Fiscal Year: 2009
    ..of allenes, 4) investigate the scope of the Au-catalyzed intramolecular hydroarylation of chiral allenyl alcohols, 5) optimize and expand the scope of the Au- catalyzed intramolecularasymmetric hydroalkoxylationof allenes, 6) ..
  59. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  60. Asymmetric Nucleophilic Catalysis
    Gregory C Fu; Fiscal Year: 2013
    ..A diverse array of reactions (e.g., kinetic resolutions of alcohols and amines, annulations, couplings of ketenes with acylating agents, and 3 additions) will be examined...
  61. EFFECTS OF ETHANOL AND ANESTHETICS ON BIOLOGIC MEMBRANES
    THEODORE TARASCHI; Fiscal Year: 1993
    ..and NMR (1H,2H,13C,31P and 19F) to investigate the molecular nature of the perturbations caused by ethanol, other alcohols and anesthetics with well-defined model membranes and biological membranes...
  62. Symposium on Aldo-Keto Reductases & Toxicant Metabolism
    TREVOR PENNING; Fiscal Year: 2002
    ..Often they catalyze the conversion of carbonyl groups to alcohols so that the parent compound can be conjugated and eliminated...
  63. REGULATION OF ALCOHOL DEHYDROGENASE GENE EXPRESSION
    Gregg Duester; Fiscal Year: 2000
    ..other classes of ADH are inefficient with ethanol suggesting they have evolved to catalyze the oxidation of other alcohols. Class IV ADH is most efficient in catalyzing the oxidation of retinol (vitamin A)...
  64. TRANSCRIPTIONAL CONTROL IN EMBRYONIC PATTERN FORMATION
    JAMES POSAKONY; Fiscal Year: 1992
    The Drosophila alcohol dehydrogenase (Adh) gene encodes an enzyme which is necessary to detoxify alcohols encountered by the fly in its food sources. The gene is expressed at high levels in the larval and adult stages of development...
  65. New Alkene Difunctionalization Reactions for Organic Synthesis
    John P Wolfe; Fiscal Year: 2013
    ..All three aims involve the invention of new types of Pd-catalyzed reactions of aryl/alkenyl halides with amines/alcohols bearing pendant alkenes...
  66. Metal Catalyzed 1,2-Amino-Alcohol & Diamine Synthesis
    DONALD WATSON; Fiscal Year: 2005
    Vicinal amino-alcohols and diamines are an important class of compounds that are difficult to access in rapid and enantioselective fashion...