polyhydroxyethyl methacrylate

Summary

Summary: A biocompatible, hydrophilic, inert gel that is permeable to tissue fluids. It is used as an embedding medium for microscopy, as a coating for implants and prostheses, for contact lenses, as microspheres in adsorption research, etc.

Top Publications

  1. ncbi Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts
    Yusuke Katayama
    matREGEN Corporation, 200 College Street, Suite 28, Toronto, Ont, Canada M5S 3E5
    Biomaterials 27:505-18. 2006
  2. pmc Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation
    Gérrard Eddy Jai Poinern
    Murdoch Applied Nanotechnology Research Group, Murdoch University, Murdoch, WA, Australia
    Int J Nanomedicine 6:2167-74. 2011
  3. ncbi Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury
    Ajay Bakshi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosurg Spine 1:322-9. 2004
  4. ncbi Chondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits
    Eftal Gudemez
    Department of Orthopaedic Surgery and Traumatology, Kirikkale University School of Medicine, Kirikkale, Turkey
    J Hand Surg Am 27:293-306. 2002
  5. ncbi Polymer hydrogels usable for nervous tissue repair
    P Lesny
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague, Czech Republic
    J Chem Neuroanat 23:243-7. 2002
  6. ncbi High capacity binding of antibodies by poly(hydroxyethyl methacrylate) nanoparticles
    Nevra Oztürk
    Adnan Menderes University, Chemistry Department, Aydin, Turkey
    Colloids Surf B Biointerfaces 67:14-9. 2008
  7. ncbi Incorporation of a designed ruthenium nitrosyl in PolyHEMA hydrogel and light-activated delivery of NO to myoglobin
    Genevieve M Halpenny
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Inorg Chem 46:6601-6. 2007
  8. ncbi Nerve guidance channels as drug delivery vehicles
    Alexandra Piotrowicz
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St, Toronto, Ont, Canada
    Biomaterials 27:2018-27. 2006
  9. ncbi Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies
    Tai Li Tsou
    Institute of Preventive Medicine, National Defense Medical Center, National Defense University, P O Box 90048 700, Sanshia, Taipei, Taiwan, Republic of China
    J Mater Sci Mater Med 16:95-100. 2005
  10. ncbi PHEMA hydrogels obtained by a novel low-heat curing procedure with a potential for in situ preparation
    Paolo Ferruti
    Dipartimento di Chimica Organica e Industriale, via Venezia 21, 20123 Milan, Italy
    Macromol Biosci 4:591-600. 2004

Detail Information

Publications193 found, 100 shown here

  1. ncbi Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts
    Yusuke Katayama
    matREGEN Corporation, 200 College Street, Suite 28, Toronto, Ont, Canada M5S 3E5
    Biomaterials 27:505-18. 2006
    ..These coil-reinforced tubes demonstrated equivalence to autografts for nerve regeneration, demonstrating the importance of channel design to regenerative capacity and more specifically the impact of patency to regeneration...
  2. pmc Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation
    Gérrard Eddy Jai Poinern
    Murdoch Applied Nanotechnology Research Group, Murdoch University, Murdoch, WA, Australia
    Int J Nanomedicine 6:2167-74. 2011
    ..This preliminary study suggests that using 100 μg of pHEMA nanoparticles as a nanocarrier/adjuvant produced a reduction in virus shedding and improved the immune response to the DNA vaccine pCAG-HAk...
  3. ncbi Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury
    Ajay Bakshi
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosurg Spine 1:322-9. 2004
    ..In this study, the authors evaluated the results of implanting a mechanically matched hydrogel-based scaffold to treat SCI...
  4. ncbi Chondroitin sulfate-coated polyhydroxyethyl methacrylate membrane prevents adhesion in full-thickness tendon tears of rabbits
    Eftal Gudemez
    Department of Orthopaedic Surgery and Traumatology, Kirikkale University School of Medicine, Kirikkale, Turkey
    J Hand Surg Am 27:293-306. 2002
    b>Polyhydroxyethyl methacrylate (pHEMA) membranes coated on one side with chondroitin sulfate (CS) were used to block adhesion physically and to reduce friction between healing flexor tendons and the surrounding tissue in rabbit forepaws ..
  5. ncbi Polymer hydrogels usable for nervous tissue repair
    P Lesny
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20, Prague, Czech Republic
    J Chem Neuroanat 23:243-7. 2002
    ..In the pHPMA hydrogels, we found a massive ingrowth of connective tissue elements. These changes were accompanied by corresponding changes in the extracellular space volume fraction and tortuosity of the hydrogels...
  6. ncbi High capacity binding of antibodies by poly(hydroxyethyl methacrylate) nanoparticles
    Nevra Oztürk
    Adnan Menderes University, Chemistry Department, Aydin, Turkey
    Colloids Surf B Biointerfaces 67:14-9. 2008
    ..2 mg/g. Much higher binding values (up to 843 mg/g) were obtained for the PHEMA-IMEO nanoparticles. IgG could be repeatedly bound and eluted on PHEMA-IMEO nanoparticles without noticeable loss in the IgG binding capacity...
  7. ncbi Incorporation of a designed ruthenium nitrosyl in PolyHEMA hydrogel and light-activated delivery of NO to myoglobin
    Genevieve M Halpenny
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
    Inorg Chem 46:6601-6. 2007
    ..The photoactivity of 1-pHEMA is strictly dependent on exposure to UV light...
  8. ncbi Nerve guidance channels as drug delivery vehicles
    Alexandra Piotrowicz
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St, Toronto, Ont, Canada
    Biomaterials 27:2018-27. 2006
    ..Notwithstanding, the liquid-liquid centrifugal casting process is promising for localized and controlled release of multiple factors that are key to tissue regeneration...
  9. ncbi Poly(2-hydroxyethyl methacrylate) wound dressing containing ciprofloxacin and its drug release studies
    Tai Li Tsou
    Institute of Preventive Medicine, National Defense Medical Center, National Defense University, P O Box 90048 700, Sanshia, Taipei, Taiwan, Republic of China
    J Mater Sci Mater Med 16:95-100. 2005
    ..Comparison with the drug-soaked membranes, the newly synthesized 1% CIP-pHEMA membrane (cross-linked with 4% EGDMA) sustains the release of the entrapped drug and maintains the antibacterial activity up to 12 days...
  10. ncbi PHEMA hydrogels obtained by a novel low-heat curing procedure with a potential for in situ preparation
    Paolo Ferruti
    Dipartimento di Chimica Organica e Industriale, via Venezia 21, 20123 Milan, Italy
    Macromol Biosci 4:591-600. 2004
    ..However, the much shorter curing time combined with the far lower curing temperature endow the new hydrogels with a higher potential in view of specific surgical requirements, and particularly for in situ preparation...
  11. ncbi Long-term in vivo biomechanical properties and biocompatibility of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) nerve conduits
    Jason S Belkas
    Division of Neurosurgery and Neuroscience Research Program, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ont, Canada, M4N 3M5
    Biomaterials 26:1741-9. 2005
    ..Tubes also demonstrated signs of calcification, which increased from 8 to 16 weeks. To overcome these issues, future nerve conduits will be re-designed to be more robust and biocompatible...
  12. ncbi Effects of bacterial adhesion with respect to the type of material, structure and design of intraocular lenses
    J I Alava
    INASMET Foundation, Materials Research Centre, Spain
    J Mater Sci Mater Med 16:313-7. 2005
    ..These lenses were then exposed to infectious conditions in order to evaluate their responses to the bacterial environment...
  13. ncbi Effects of the length of crosslink chain on poly(2-hydroxyethyl methacrylate) (pHEMA) swelling and biomechanical properties
    G Mabilleau
    INSERM, EMI 0335 LHEA, Angers, F 49045 France
    J Biomed Mater Res A 77:35-42. 2006
    ..TEGDA and PEGDA appeared to be the two most suitable crosslinking agents for controlled release of bioactive molecules in bone...
  14. ncbi Biological response to a supraDescemetic synthetic cornea in rabbits
    Josef Stoiber
    Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, FL 33136, USA
    Arch Ophthalmol 122:1850-5. 2004
    ..To evaluate the biocompatibility of a novel nonpenetrating keratoprosthesis (supraDescemetic synthetic cornea) in a rabbit model...
  15. ncbi Dynamic wettability properties of a soft contact lens hydrogel
    Howard A Ketelson
    Alcon Laboratories Inc, Research and Development, Consumer Products, 6201 South Freeway, Fort Worth, TX 76134, USA
    Colloids Surf B Biointerfaces 40:1-9. 2005
    ..These results suggested that the adsorbed lysozyme on the pHEMA-MAA hydrogel had no significant influence on its wetting properties when the hydrogel was pre-treated with T1304...
  16. ncbi Synthesis and characterisation of poly(2-hydroxyethyl methacrylate) polyelectrolyte complexes
    F Rosso
    Department of Anaesthesological, Surgical and Emergency Sciences, Second University of Naples, Piazza Miraglia, 1, 80138 Naples, Italy
    J Mater Sci Mater Med 15:679-86. 2004
    ..Cytotoxicity and cytocompatibility studies demonstrated that all materials were not toxic, moreover, the presence of a cationic charge excess on 10:1:2 terpolymer surface was able to promote fibroblast adhesion...
  17. ncbi Recent advances in biocompatible surface-modifying additives for cardiopulmonary bypass
    Venkataramana Vijay
    Cardiothoracic Surgery, Albert Einstein College of Medicine, New York, USA
    Perfusion 18:41-5. 2003
  18. ncbi Binding of D-mannose to poly(2-hydroxyethyl methacrylate) hydrogels by azo coupling
    Jirí Labský
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    Biomaterials 24:4031-6. 2003
    ....
  19. ncbi Fiber templating of poly(2-hydroxyethyl methacrylate) for neural tissue engineering
    Lauren Flynn
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ont, Canada M5S 3E5
    Biomaterials 24:4265-72. 2003
    ..Small and large channel scaffolds had, respectively, EWCs of 55.0+/-1.2% and 56.2+/-2.9%, porosities of 35+/-1% and 40+/-1% and compressive moduli of 191+/-7 and 182+/-4kPa...
  20. ncbi Biodegradable hydrogels obtained by photocrosslinking of dextran and polyaspartamide derivatives
    G Pitarresi
    Dipartimento di Chimica e Tecnologie Farmaceutiche, Universita di Palermo, Via Archirafi 32, 90123, Palermo, Italy
    Biomaterials 24:4301-13. 2003
    ..Finally, the suitability of hydrogels deriving from functionalized dextran, crosslinked alone or in the presence of PHG, for drug delivery systems has been investigated choosing theophylline as a model drug...
  21. ncbi Biodegradability of poly (2-hydroxyethyl methacrylate) in the presence of the J774.2 macrophage cell line
    G Mabilleau
    INSERM EMI 0335 LHEA, Faculté de Médecine University of Angers, Rue Haute de Reculee, 49045 Angers Cedex, France
    Biomaterials 25:5155-62. 2004
    ..In conclusion, linear pHEMA swells in biological fluids, activates macrophages in close contact with the polymer and can be progressively eroded...
  22. ncbi Drug release characteristics of phase separation pHEMA sponge materials
    Xia Lou
    Centre for Ophthalmology and Visual Science and Lions Eye Institute, University of Western Australia, 2 Verdun Street, Nedlands, WA 6009, Australia
    Biomaterials 25:5071-80. 2004
    ..The effect of morphological variations, revealed by the environmental scanning electron microscopy, and polymer/solvent volume fractions on these properties were discussed...
  23. ncbi Surface friction of hydrogels with well-defined polyelectrolyte brushes
    Yutaka Ohsedo
    Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan
    Langmuir 20:6549-55. 2004
    ..The strong polymer length and sliding velocity dependence indicate a dynamic mechanism of the polymer brush effect...
  24. ncbi Tethered protein/peptide-surface-modified hydrogels
    Jingjing Bi
    LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Biomater Sci Polym Ed 15:905-16. 2004
    ..Future studies will evaluate the cellular response to these surface-modified materials in vitro and in vivo...
  25. ncbi Micro- and nanoscale modification of poly(2-hydroxyethyl methacrylate) hydrogels by AFM lithography and nanoparticle incorporation
    A Podesta
    Centro Interdisciplinaire Materiali e Interfacce Nanostrutturati, Universita di Milano, Via Celoria 16, 20133 Milano, Italy
    J Nanosci Nanotechnol 5:425-30. 2005
    ..We also demonstrate that it is possible to incorporate carbon nanoparticles in the hydrogel matrix by supersonic cluster beam deposition...
  26. ncbi Acrylic scaffolds with interconnected spherical pores and controlled hydrophilicity for tissue engineering
    R Brígido Diego
    Center for Biomaterials, UniVersidad Polité cnica de Valencia, Camino de Vera s n, 46022, Valencia, Spain
    J Mater Sci Mater Med 16:693-8. 2005
    ....
  27. ncbi Gentamicin release from photopolymerized PEG diacrylate and pHEMA hydrogel discs and their in vitro antimicrobial activities
    Fatma Ayhan
    Faculty of Science and Art, Department of Chemistry, Mugla University, Mugla, Turkey
    Drug Deliv 14:433-9. 2007
    ..Inhibition zone formation also confirms that gentamicin sulphate preserves its antimicrobial activity after subjected to photopolymerization conditions...
  28. ncbi Evaluation of water sorption property and in vitro blood compatibility of poly(2-hydroxyethyl methacrylate) (PHEMA) based semi interpenetrating polymer networks (IPNs)
    A K Bajpai
    Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur 482 001, MP, India
    J Mater Sci Mater Med 19:1921-33. 2008
    ....
  29. ncbi Completely aqueous procedure for the growth of polymer brushes on polymeric substrates
    Parul Jain
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    Langmuir 23:11360-5. 2007
    ..PHEMA (250 nm thick) and PDMAEMA (40 nm thick) brushes were grown in 2 h from surfaces modified with polycationic initiators. Moreover, this procedure is effective for growing brushes in the pores of PES membranes...
  30. ncbi Poly(HEMA) hydrogels with controlled pore architecture for tissue regeneration applications
    Hana Studenovská
    Department of Bioanalogous and Special Polymers, Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06, Prague 6, Czech Republic
    J Mater Sci Mater Med 19:615-21. 2008
    ..Highly water-swollen polymer gels were characterized with high pressure (low vacuum) scanning electron microscopy (AquaSEM). The morphology of voids remaining after removing the solid PLLA porogen (the macropores) was clearly shown...
  31. ncbi Chemical-physical and preliminary biological properties of poly (2-hydroxyethylmethacrylate)/poly-(epsilon-caprolactone)/hydroxyapa- tite composite
    C Giordano
    Department of Chemistry, Materials and Chemical Engineering Giulio Natta, Politecnico di Milano, Milano, Italy
    J Mater Sci Mater Med 18:653-60. 2007
    ..The results indicate that the novel PHEMA/PCL/HA composite is a promising candidate as filler or substitute for spongy bone for orthopaedic applications...
  32. ncbi In-vitro study of the spontaneous calcification of PHEMA-based hydrogels in simulated body fluid
    - Zainuddin
    Department of Chemistry, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
    J Mater Sci Mater Med 17:1245-54. 2006
    ..2H2O) as the precursors of hydroxyapatite [Ca(10)(PO(4))6(OH)2]. The presence of carbonate in the deposits was also detected during the calcification of PHEMA based hydrogels in SBF solution...
  33. ncbi Synthesis and characterization of hyperbranched polyglycerol hydrogels
    Marion H M Oudshoorn
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Sorbonnelaan 16, PO Box 80082, 3508 TB Utrecht, The Netherlands
    Biomaterials 27:5471-9. 2006
    ..Hydrogels based on HyPG have great potential as drug delivery matrices and for tissue engineering purposes...
  34. ncbi Dynamic wettability of pHEMA-based hydrogel contact lenses
    Carole Maldonado-Codina
    Eurolens Research, Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Ophthalmic Physiol Opt 26:408-18. 2006
    ..Lenses investigated were made from polyhydroxyethyl methacrylate, hydroxyethyl methacrylate/methacrylic acid and hydroxyethyl methacrylate/glycerol methacrylate...
  35. ncbi Imprinted soft contact lenses as norfloxacin delivery systems
    Carmen Alvarez-Lorenzo
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    J Control Release 113:236-44. 2006
    ..These results prove that ITC is a useful tool for the optimization of the structure of the imprinted cavities in order to obtain efficient therapeutic soft contact lenses...
  36. ncbi Evaluation of surface roughness of hydrogels by fractal texture analysis during swelling
    G Mabilleau
    INSERM, EMI 0335 LHEA, Faculte de Medecine, 49045 Angers Cedex, France
    Langmuir 22:4843-5. 2006
    ..Image analysis using fractal algorithms appears to be the most interesting technique for the quantitative exploration of surfaces of hydrated materials that cannot be measured by conventional methods...
  37. ncbi Synthesis, swelling behavior, and biocompatibility of novel physically cross-linked polyurethane-block-poly(glycerol methacrylate) hydrogels
    Kibret Mequanint
    Department of Chemical and Biochemical Engineering, and Graduate Program in Biomedical Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada
    Biomacromolecules 7:883-91. 2006
    ..These hydrogels have potential in a number of biomedical applications such as drug delivery and scaffolds for tissue engineering...
  38. ncbi [Synthesis of nanoparticles for dental drug delivery systems]
    József Bakó
    Debreceni Egyetem, Orvos es Egészségtudományi Centrum Fogorvostudományi Kar, Fogpótlastani Tanszék
    Fogorv Sz 100:109-13. 2007
    ..The nanoparticles are suitable for incorporation into a hydrogel matrix and to design new drug delivery devices for dental applications...
  39. ncbi Effect of the crosslinking degree and the nickel salt load on the thermal decomposition of poly(2-hydroxyethyl methacrylate) hydrogels and on the metal release from them
    César Teijón
    Departamento de Ingenieria Quimica, Facultad de Quimicas, Universidad Complutense de Madrid, 28040 Madrid, Spain
    J Colloid Interface Sci 295:393-400. 2006
    ..On the other hand, the presence of nickel salt induced an evident thermal instability in the polymeric matrices, although all the polymeric systems can be considered thermally stable...
  40. ncbi A model system to assess key vascular responses to biomaterials
    Eugene A Sprague
    Department of Radiology, The University of Texas Health Science Center at San Antonio, Texas 78229, USA
    J Endovasc Ther 12:594-604. 2005
    ..Endothelial migration onto these surfaces was used as an index of vascular healing...
  41. ncbi Swellable coatings for hearing aid applications
    Sung Il Choi
    Chemical Engineering Department, Brigham Young University, Provo, UT 84602, USA
    J Biomater Appl 20:123-35. 2005
    ..In the swollen state, the mechanical properties were much reduced. The potential use of these materials on hearing aids has been discussed in this article...
  42. ncbi The effect of charged groups on protein interactions with poly(HEMA) hydrogels
    Megan S Lord
    Graduate School of Biomedical Engineering, The University of New South Wales, Sydney NSW 2052, Australia
    Biomaterials 27:567-75. 2006
    ..A net mass decrease was observed for cholesterol interacting with each of the hydrogel materials, while a mass increase was observed on PMMA...
  43. ncbi Comparison of silicone and non-silicone hydrogel soft contact lenses used as a bandage after LASEK
    Raquel Gil-Cazorla
    Vissum Corporación Oftalmológica de Madrid, C Santa Hortensia, 58, 28002, Madrid, Spain
    J Refract Surg 24:199-203. 2008
    ..To evaluate two different soft contact lens materials for continuous-wear bandage contact lenses after laser epithelial keratomileusis (LASEK)...
  44. ncbi Effects of negatively charged groups (carboxymethyl) on the calcification of poly(2-hydroxyethyl methacrylate)
    R Filmon
    LHEA GEROM, Laboratoire d Histologie Embryologie, Faculté de Médecine and CHU d Angers, France
    Biomaterials 23:3053-9. 2002
    ..The presence of AlkP favours the mineralization process more than the existence of surface negative groups on the polymer. Cells preferentially adhere to the polymer when hydroxyapatite crystals were developed...
  45. ncbi AFM and SFG studies of pHEMA-based hydrogel contact lens surfaces in saline solution: adhesion, friction, and the presence of non-crosslinked polymer chains at the surface
    Seong Han Kim
    Department of Chemistry, University of California at Berkley, 94720, USA
    Biomaterials 23:1657-66. 2002
    ..Fully hydrated in saline solution, the non-crosslinked domains extended more than tens of nanometers into solution and were mobile...
  46. ncbi Mechanical properties and radiopacity of experimental glass-silica-metal hybrid composites
    Klaus D Jandt
    Department of Oral and Dental Science, Biomedical Engineering and Biomaterials Science Section, University of Bristol, Lower Maudlin Street, UK
    Dent Mater 18:429-35. 2002
    ....
  47. ncbi Multi-layered microcapsules for cell encapsulation
    S M Chia
    Faculty of Medicine, National University of Singapore, Singapore
    Biomaterials 23:849-56. 2002
    ..The advantages and limitations of these microcapsules for tissue engineering are discussed...
  48. ncbi Tissue responses to Hydron, assessed by intramuscular implantation
    R J Reid
    The University of Adelaide, South Australia
    Int Endod J 25:199-204. 1992
    ..The amount of apparently calcified material increased with time. Inflammation was not a prominent tissue response for any of the test materials, nor was a foreign body giant cell response...
  49. ncbi Tissue responses to Hydron, assessed by intraosseous implantation
    R J Reid
    The University of Adelaide, South Australia
    Int Endod J 25:192-8. 1992
    ..Bone formed in very close apposition to the polymerized Hydron, whereas a soft tissue capsule separated the regenerated bone from implants of AH26 and Teflon...
  50. ncbi Comparison of bacterial and tissue cell initial adhesion on hydrophilic/hydrophobic biomaterials
    Ayşe Gönen Karakeçili
    Hacettepe University, Chemical Engineering Department, Beytepe, Ankara, Turkey
    J Biomater Sci Polym Ed 13:185-96. 2002
    ..In contrast to the case of bacterial adhesion, no relationship was found between polymer hydrophobicity and mammalian cell adherence...
  51. ncbi Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices
    T D Dziubla
    Department of Chemical Engineering, Drexel University, Philadelphia, PA 19104, USA
    Biomaterials 22:2893-9. 2001
    ..These results indicate that it may be possible to use PHEMA sponges for a tissue intermediary for long-term implantable drug delivery devices...
  52. ncbi A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites
    Jie Song
    Materials Sciences Division, Lawrence Berkeley National Laboratory, Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 125:1236-43. 2003
    ..This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength...
  53. ncbi Impact of manufacturing technology and material composition on the surface characteristics of hydrogel contact lenses
    Carole Maldonado-Codina
    Eurolens Research, Faculty of Life Sciences, The University of Manchester, Moffat Building, PO Box 88, Manchester, M60 1QD, United Kingdom
    Clin Exp Optom 88:396-404. 2005
    ..Our aim was to investigate the impact of manufacturing method and material composition on the surface characteristics of hydrogel contact lenses...
  54. ncbi [15-deoxy-Delta(12,14)-prostaglandin J(2) induces anoikis of hepatocellular carcinoma cells: an in vitro experiment]
    Liang qi Cao
    Department of Hepatobiliary Surgery, First Affiliated Hospital of Sun Yat sen University, Guangzhou, China
    Zhonghua Yi Xue Za Zhi 87:3001-5. 2007
    ..To investigate the effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on the anoikis of hepatocellular carcinoma (HC) cells and mechanisms thereof...
  55. ncbi Impact of manufacturing technology and material composition on the mechanical properties of hydrogel contact lenses
    Carole Maldonado-Codina
    Eurolens Research, Department of Optometry and Neuroscience, UMIST, P O Box 88, Manchester M60 1QD, UK
    Ophthalmic Physiol Opt 24:551-61. 2004
    ..The five lens groups consisted of three polyhydroxyethyl methacrylate (pHEMA) lenses which were each manufactured by a different technique: lathing, spin-casting and cast-..
  56. ncbi Induction of apoptosis of detached oral squamous cell carcinoma cells by safingol. Possible role of Bim, focal adhesion kinase and endonuclease G
    Takayuki Noda
    Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka, Japan
    Apoptosis 14:287-97. 2009
    ..in the absence of safingol even if their attachment was blocked by coating the culture plates with polyhydroxyethyl methacrylate. Flow cytometric analysis and agarose gel electrophoresis of cellular DNA revealed an increase in the ..
  57. pmc Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materials
    J S Mehta
    Cornea and External Disease Service, Moorfields Eye Hospital, London, UK
    Br J Ophthalmol 89:1356-62. 2005
    ....
  58. ncbi Ophthalmic application of poly(HEMA)s containing nanoparticles and dimethylacrylamide
    A Young Sung
    Department of Ophthalmic Optics, Daebul University, Jeonnam, 526 702, Korea
    J Nanosci Nanotechnol 12:5210-5. 2012
    ..The copolymers have excellent oxygen permeability, indicating that the material can be used to fabricate hydrogel contact lenses with high oxygen transmissibility...
  59. ncbi XPS and surface-MALDI-MS characterisation of worn HEMA-based contact lenses
    S L McArthur
    Cooperative Research Centre for Eye Research and Technology CSIRO Molecular Science, Clayton, Victoria, Australia
    Biomaterials 22:3295-304. 2001
    ....
  60. ncbi The Chirila Keratoprosthesis: phase I human clinical trial
    Geoffrey J Crawford
    Lions Eye Institute and Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Australia
    Ophthalmology 109:883-9. 2002
    ..To undertake a preliminary safety and performance evaluation of an artificial cornea, the Chirila Keratoprosthesis, in human patients...
  61. ncbi New monodisperse magnetic polymer microspheres biofunctionalized for enzyme catalysis and bioaffinity separations
    Daniel Horak
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Macromol Biosci 12:647-55. 2012
    ..Trypsin-modified magnetic PGMA-COOH and PHEMA-COOH microspheres are investigated in terms of their enzyme activity, operational and storage stability. The presence of IgG molecules on microspheres is confirmed...
  62. ncbi Neodymium:YAG laser posterior capsulotomy after implantation of AcrySof intraocular lenses
    James A Davison
    Wolfe Clinic, 309 East Church Street, Marshalltown, IA 50158, USA
    J Cataract Refract Surg 30:1492-500. 2004
    ..To report the incidence of neodymium:YAG (Nd:YAG) laser posterior capsulotomy after phacoemulsification and implantation of AcrySof (Alcon) intraocular lenses (IOLs)...
  63. ncbi Eccentric capsulorhexis and postoperative dysphotopsia following phacoemulsification
    Wayne Birchall
    Manchester Royal Eye Hospital, Oxford Road, Manchester, United Kingdom
    J Cataract Refract Surg 30:1378-81. 2004
    ..Miotic therapy was poorly tolerated and IOL exchange declined. The case illustrates the importance of creating a central capsulorhexis smaller than the IOL optic to reduce the risk photic phenomena and edge effect with square-edged IOLs...
  64. ncbi Unusual presentation of angle-closure glaucoma treated by phacoemulsification
    Jia kang Wang
    Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan
    J Cataract Refract Surg 30:1371-3. 2004
    ..Intraocular pressures are now normal without medication, even after mydriasis. Modern cataract surgery is an effective treatment for selected patients with appositional angle closure and IOP elevation after acute PACG...
  65. ncbi Gelatin-immobilised poly(hydroxyethyl methacrylate) cryogel for affinity purification of fibronectin
    Işık Perçin
    Department of Biology, Molecular Biology Division, Hacettepe University, Beytepe, 06800 Ankara, Turkey
    Appl Biochem Biotechnol 171:352-65. 2013
    ..The adsorption-elution cycle was repeated ten times using the same PHEMA cryogel. No remarkable decrease was detected in the adsorption capacity of the gelatin-immobilised PHEMA cryogel. ..
  66. ncbi Specificity and regenerability of short peptide ligands supported on polymer layers for immunoglobulin G binding and detection
    Yanxia Zhang
    Department of Forest Biomaterials, North Carolina State University, Raleigh, North Carolina 27695, USA
    ACS Appl Mater Interfaces 5:8030-7. 2013
    ....
  67. ncbi Pentablock copolymers of poly(ethylene glycol), poly((2-dimethyl amino)ethyl methacrylate) and poly(2-hydroxyethyl methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene delivery
    Fu Jian Xu
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore
    Biomaterials 29:3023-33. 2008
    ....
  68. ncbi Controlled preparation of thin fibrin films immobilized at solid surfaces
    Tomas Riedel
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Biomed Mater Res A 88:437-47. 2009
    ..The technique makes it possible to coat the inner surface of porous scaffolds with surface-attached fibrin gel while preserving free volume for cell migration into the pores...
  69. ncbi Angiogenic activity in damaged skeletal muscle
    G D Phillips
    Department of Surgery, University of Minnesota, Minneapolis 55455
    Proc Soc Exp Biol Med 193:197-202. 1990
    ..Four hundred to 500 micrograms of the skeletal muscle-derived extract were required to produce maximum vessel ingrowth. The control, Dulbecco's phosphate-buffered saline in Hydron, failed to stimulate neovascularization...
  70. ncbi Poly(2-hydroxyethyl methacrylate) microspheres/liquid poly(dimethylsiloxane) composition for correction of small defects in face: histological evaluation in animal experiment
    D Horak
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06, Prague 6, Czech Republic
    J Mater Sci Mater Med 17:123-9. 2006
    ..Results of histological investigations demonstrate a good prospect of the proposed composition for contour and bulk facioplasty of small soft tissue defects and skin wrinkles...
  71. ncbi Lysozyme purification with dye-affinity beads under magnetic field
    Nilgün Başar
    Department of Chemistry, Hacettepe University, Ankara, Turkey
    Int J Biol Macromol 41:234-42. 2007
    ..The purity of the desorbed lysozyme was about 87.4% with recovery about 79.6%. The specific activity of the desorbed lysozyme was high as 41.586 U/mg...
  72. ncbi Preparation and in vitro evaluation of topical formulations based on polystyrene-poly-2-hydroxyl methacrylate nanoparticles
    Xiao Wu
    Department of Pharmacy, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    Mol Pharm 6:1449-56. 2009
    ..In conclusion, the loading of a lipophilic "active" into nanoparticles, and its subsequent release when these formulations are applied topically, are sensitive to the composition and relative hydrophobicity of the carrier...
  73. ncbi Biocompatibility of plasma enhanced chemical vapor deposited poly(2-hydroxyethyl methacrylate) films for biomimetic replication of the intestinal basement membrane
    Courtney A Pfluger
    Department of Chemical Engineering, Northeastern University, Boston, Massachusetts 02115, USA
    Biomacromolecules 11:1579-84. 2010
    ..Results indicate that CVD pHEMA is useful for development of precise (micrometer-scale) topographically biomimetic substrates for cell culture...
  74. ncbi Chondrogenic differentiation potential of human mesenchymal stem cells photoencapsulated within poly(ethylene glycol)-arginine-glycine-aspartic acid-serine thiol-methacrylate mixed-mode networks
    Chelsea N Salinas
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, USA
    Tissue Eng 13:1025-34. 2007
    ..Incorporation of this peptide sequence not only allows for sustained viability, but also contributes to initiating chondrogenesis...
  75. ncbi Inflammatory nodules following soft tissue filler use: a review of causative agents, pathology and treatment options
    Jennifer A Ledon
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1475 NW 12th Ave, 2nd Floor, Miami, FL, 33136, USA
    Am J Clin Dermatol 14:401-11. 2013
    ..With this knowledge, practitioners may expeditiously recognize and manage this common side effect and thus maximize functional and aesthetic benefit. ..
  76. ncbi Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers
    B C Shin
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    J Biomater Sci Polym Ed 12:467-77. 2001
    ..Surprisingly, however, the polymer coated probes exhibited less thrombus formation that did the bare probes after blood exposure...
  77. ncbi Characteristics of tissue-engineered cartilage on macroporous biodegradable PLGA scaffold
    Chung Hwan Baek
    Department of Otorhinolaryngology Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Laryngoscope 116:1829-34. 2006
    ..The purpose of this study was to establish in vivo culture of chondrocytes on biodegradable, poly-D,L-lactic-co-glycolic acid (PLGA) scaffolds and to analyze the characteristics of the reconstructed cartilage...
  78. ncbi Vitamin E triggers poly(2-hydroxyethyl methacrylate) (PHEMA) embolic potential: a proposed application for endovascular surgery
    Filippo Renò
    Research Centre for Biocompatibility and Tissue Engineering, Clinical and Experimental Medicine Department, University of Eastern Piedmont A Avogadro, Via Solaroli 17, 28100 Novara, Italy
    J Biomater Sci Polym Ed 22:641-50. 2011
    ..These effects are developed due to a combination of issues such as surface hydrophobicity and plasma protein adsorption induced by the presence of Vit.E, suggesting that Vit.E blending could improve the use of PHEMA as embolizing agent...
  79. ncbi Diplopia and periorbital mass associated with Miragel buckling explant
    Eun Jee Chung
    The Institute of Vision Research and Department of Ophthalmology, College of Medicine, Yonsei University, Seoul, Korea
    Korean J Ophthalmol 18:47-51. 2004
    ..Alterations in the structural composition of the Miragel explant results in an excessive swelling that causes a restriction of the extraocular movement, and this can mimick a periorbital mass lesion...
  80. ncbi Dual delivery of placental growth factor and vascular endothelial growth factor from poly(hydroxyethyl methacrylate-co-methyl methacrylate) microcapsules containing doubly transfected luciferase-expressing L929 cells
    Dangxiao Cheng
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Tissue Eng Part A 15:1929-39. 2009
    ..Thus successful modulation of the host response to microencapsulated cells may require enhanced vascularization and manipulation of the immune response, even with nominally syngeneic cells...
  81. ncbi Adverse reactions caused by consecutive injections of different fillers in the same facial region: risk assessment based on the results from the Injectable Filler Safety study
    F Bachmann
    Division of Evidence Based Medicine, Department of Dermatology, Charite Universitatsmedizin Berlin, Charite, Chariteplatz 1, Berlin, Germany
    J Eur Acad Dermatol Venereol 25:902-12. 2011
    ..The combination of different injectable fillers in one area is considered to increase the risk of adverse reactions...
  82. ncbi Presence of pores and hydrogel composition influence tensile properties of scaffolds fabricated from well-defined sphere templates
    Stephanie M LaNasa
    Department of Chemical and Biological Engineering, The University of Colorado at Boulder, Boulder, Colorado 80309, USA
    J Biomed Mater Res B Appl Biomater 96:294-302. 2011
    ..Together, these findings will help to design better hydrogel scaffolds for applications where gross mechanical properties and porosity are critical...
  83. ncbi Cobalt, chromium and nickel affect hydroxyapatite crystal growth in vitro
    G Mabilleau
    Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
    Acta Biomater 6:1555-60. 2010
    ..However, further investigation should be conducted to further elucidate the effects of metal incorporation on bone mineral and the functional consequences...
  84. ncbi Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels
    Dajun D Sun
    Department of Pharmaceutical Sciences, University of Toronto, 144 College St, Toronto, Ontario, Canada
    Eur J Pharm Biopharm 81:149-58. 2012
    ..Furthermore, a robust physical stability has been demonstrated in IND-PHEMA ASD with no drug precipitation for up to 8 months at IND loadings below 16.7% under direct open cup exposure to accelerated stability conditions (40°C/75% RH)...
  85. ncbi Biomimetic macroporous hydrogels: protein ligand distribution and cell response to the ligand architecture in the scaffold
    Irina N Savina
    School of Pharmacy and Biomolecular Sciences, Brighton University, Brighton, UK
    J Biomater Sci Polym Ed 20:1781-95. 2009
    ..The optimal type of modification varies depending on intrinsic properties of proteins and MHs...
  86. ncbi Chemically-bound nerve growth factor for neural tissue engineering applications
    Terri Adams Kapur
    Department of Chemical Engineering and Applied Chemistry University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada
    J Biomater Sci Polym Ed 14:383-94. 2003
    ..This photochemical technique may be useful to spatially control the amount of NGF bound to PHEMA using light and thus build a stable concentration gradient...
  87. ncbi Novel injectable biomimetic hydrogels with carbon nanofibers and self assembled rosette nanotubes for myocardial applications
    Xiangling Meng
    Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA
    J Biomed Mater Res A 101:1095-102. 2013
    ..In summary, the properties of these injectable composites make them promising candidates for myocardial tissue engineering applications and should be further studied...
  88. ncbi Comparison of properties between NIPAAm-based simultaneously physically and chemically gelling polymer systems for use in vivo
    Hanin H Bearat
    The School of Biological and Health Systems Engineering, Center for Interventional Biomaterials, ECG 334, Arizona State University, Tempe, AZ 85287 9709, USA
    Acta Biomater 8:3629-42. 2012
    ..Cell studies illustrated good growth of cells exposed to the gels. Both hydrogels, although possessing slight differences, demonstrate the capability of being injected in vivo for use as embolic agents for occlusion of aneurysms...
  89. ncbi Multicomponent polymeric micelles based on polyaspartamide as tunable fluorescent pH-window biosensors
    Yuri Antonio Diaz-Fernandez
    Dipartimento di Chimica Generale, Universita di Pavia, Viale Taramelli 12, 27100 Pavia, Italy
    Biosens Bioelectron 26:29-35. 2010
    ..Dialysis experiments demonstrate that the micellar device exibits an efficient retention ability of all molecular components, including cosurfactants, thus candidating for in vivo use...
  90. ncbi Magnetically guided release of ciprofloxacin from superparamagnetic polymer nanocomposites
    Rashmi Gupta
    Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur M P 482001, India
    J Biomater Sci Polym Ed 22:893-918. 2011
    ..It was found that magnetic nanocomposites were biocompatible and superparamagnetic in nature and could be used as a smart drug carrier for controlled and targeted drug delivery...
  91. ncbi Substrate-induced polarisation of cultured epitheliocytes and fibroblasts: non-reactivity of Ras-transformed cells
    T G Moizhess
    Cancer Research Centre of Russian Academy of Medical Sciences, Kashirskoe Shosse, 24, 115478 Moscow, Russia
    Cell Biol Int 25:931-4. 2001
    ..In contrast, transformed cells express polarised phenotype regardless of the substrate...
  92. ncbi Surface crosslinking for delayed release of proxyphylline from PHEMA hydrogels
    Linfeng Wu
    Department of Chemical and Biological Engineering, Box 870203, 201 7th Avenue, The University of Alabama, Tuscaloosa, AL 35487, USA
    Int J Pharm 349:1-10. 2008
    ....
  93. ncbi [A man with progressive diplopia]
    Niels Crama
    Universitair Medisch Centrum Nijmegen, afd Oogheelkunde, Nijmegen, The Netherlands
    Ned Tijdschr Geneeskd 156:A3185. 2012
    ..A 71-year-old man presented with progressive diplopia due to swelling of a Miragel explant. Removal of the explant resulted in relief of symptoms...
  94. ncbi Capacity and tolerance of a new device for ocular drug delivery
    Rachel T Pijls
    Centre for Biomaterials Research, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Int J Pharm 341:152-61. 2007
    ..Ophthalmologic examinations and photographs of the eye indicated no signs of irritation. Volunteers reported that the presence of the device in the eye could be noticed, but no irritation was reported...
  95. ncbi Conformal coating of small particles and cell aggregates at a liquid-liquid interface
    M H May
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada
    Ann N Y Acad Sci 875:126-34. 1999
    ..Aggregates of HepG2 cells and pancreatic islets were coated and remained viable...
  96. ncbi Bag-in-the-lens implantation of intraocular lenses
    Marie José B R Tassignon
    Department of Ophthalmology, University of Antwerp, Tassignon, De Groot, Edegem, Belgium
    J Cataract Refract Surg 28:1182-8. 2002
    ..To report a new intraocular lens (IOL) and an IOL implantation concept, the bag-in-the-lens implantation technique, designed to prevent posterior capsule opacification (PCO)...
  97. ncbi Controlling modulus and morphology of hydrogel tubes through surface modification
    Cristina Enescu
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON, Canada M5S 3E5
    J Biomater Sci Polym Ed 15:215-27. 2004
    ..Release from the molds was easiest with ethoxy- and amine-functionalized silane mold modifications...
  98. ncbi Non-connected versus interconnected macroporosity in poly(2-hydroxyethyl methacrylate) polymers. An X-ray microtomographic and histomorphometric study
    R Filmon
    GEROM LHEA Laboratoire d Histologie Embryologie, Faculté de Médecine and CHU d Angers, 49045 Angers, France
    J Biomater Sci Polym Ed 13:1105-17. 2002
    ..The disconnected pores were unstained. Macroporous polymers can be prepared with water-soluble porogens. X-ray microtomography appears a useful tool to measure porosity and interconnectedness...
  99. ncbi [Episcleral Miragel buckling elements removal. A clinical case-series]
    J F Le Rouic
    Service d Ophtalmologie, Hotel Dieu de Paris, 1, place du parvis de Notre Dame, 75004 Paris
    J Fr Ophtalmol 25:1002-6. 2002
    ..The aim of this study was to determine the characteristics and the outcome of patients needing Miragel buckling removal...
  100. ncbi Enhanced osteoblast adhesion on self-assembled nanostructured hydrogel scaffolds
    Lijie Zhang
    Division of Engineering, Brown University, Providence, Rhode Island 02912, USA
    Tissue Eng Part A 14:1353-64. 2008
    ..In summary, the present results demonstrated that HRNs can improve properties of one particular hydrogel (pHEMA) and, thus, should be further investigated as a bone-healing material...
  101. ncbi PFG-NMR measurements of the self-diffusion coefficients of water in equilibrium poly(HEMA-co-THFMA) hydrogels
    Phuong Y Ghi
    Polymer Materials and Radiation Group, Department of Chemistry, and Centre for Magnetic Resonance, The University of Queensland, Brisbane, Australia 4072
    Biomacromolecules 3:554-9. 2002
    ..The self-diffusion coefficients of water in the equilibrium-hydrated copolymers were found to be dependent on the copolymer composition, decreasing with increasing THFMA content...