povidone

Summary

Summary: A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.

Top Publications

  1. ncbi Evaluation of the effects of khaya gum on the mechanical and release properties of paracetamol tablets
    O A Odeku
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Drug Dev Ind Pharm 29:311-20. 2003
  2. ncbi Effects of formulation and process variables on the release of a weakly basic drug from single unit extended release formulations
    H Kranz
    Pharmaceutical Development, Schering AG, Berlin, Germany
    Eur J Pharm Biopharm 62:70-6. 2006
  3. ncbi Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes
    R Aly
    Department of Dermatology, University of California, School of Medicine, San Francisco 94143
    Am J Infect Control 16:173-7. 1988
  4. ncbi Crystallization of hydrocortisone acetate: influence of polymers
    S L Raghavan
    Medway Sciences, NRI University of Greenwich, Central Avenue, Maritime, Kent ME44TB, Chatham, UK
    Int J Pharm 212:213-21. 2001
  5. ncbi Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone-ethylcellulose matrices
    Ritu Gupta
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Dev Ind Pharm 29:1-7. 2003
  6. ncbi Enhanced neuroprotective effects of resveratrol delivered by nanoparticles on hydrogen peroxide-induced oxidative stress in rat cortical cell culture
    Xiaowei Lu
    Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P R China
    Mol Pharm 10:2045-53. 2013
  7. ncbi Paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) nanoparticles: preparation and antitumor activity in vivo
    Zhenshu Zhu
    Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China
    J Control Release 142:438-46. 2010
  8. ncbi A comparison between povidone-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation
    Biswajit Mukherjee
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata Calcutta, India
    Eur J Pharm Biopharm 59:475-83. 2005
  9. ncbi The use of PVP as a polymeric carrier to improve the plasma half-life of drugs
    Yoshihisa Kaneda
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 25:3259-66. 2004
  10. pmc Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays
    Adam H Bates
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Parasitol 126:278-80. 2010

Detail Information

Publications245 found, 100 shown here

  1. ncbi Evaluation of the effects of khaya gum on the mechanical and release properties of paracetamol tablets
    O A Odeku
    Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria
    Drug Dev Ind Pharm 29:311-20. 2003
    ..The results suggest that khaya gum could be useful as an alternative binding agent to produce tablets with particular mechanical strength and drug release profiles...
  2. ncbi Effects of formulation and process variables on the release of a weakly basic drug from single unit extended release formulations
    H Kranz
    Pharmaceutical Development, Schering AG, Berlin, Germany
    Eur J Pharm Biopharm 62:70-6. 2006
    ..Stability studies demonstrated no degradation of the drug substance and reproducible drug release patterns for matrix tablets stored at 25 degrees C/60% RH and 30 degrees C/70% RH for up to 6 months...
  3. ncbi Comparative antibacterial efficacy of a 2-minute surgical scrub with chlorhexidine gluconate, povidone-iodine, and chloroxylenol sponge-brushes
    R Aly
    Department of Dermatology, University of California, School of Medicine, San Francisco 94143
    Am J Infect Control 16:173-7. 1988
    Chlorhexidine gluconate (Hibiclens), povidone-iodine (E-Z Scrub 201), and chloroxylenol (ParaSoft) sponge-brushes were compared for antibacterial efficacy in 2-minute surgical scrubs...
  4. ncbi Crystallization of hydrocortisone acetate: influence of polymers
    S L Raghavan
    Medway Sciences, NRI University of Greenwich, Central Avenue, Maritime, Kent ME44TB, Chatham, UK
    Int J Pharm 212:213-21. 2001
    ..The habit modification of HA by HPMC is due to different extents of adsorption on different faces of the crystal, the extent of which is dependent on the hydrogen bonding functional groups that are exposed at each face of the crystal...
  5. ncbi Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone-ethylcellulose matrices
    Ritu Gupta
    University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
    Drug Dev Ind Pharm 29:1-7. 2003
    ..Transdermal patches of the drug, employing different ratios of polymers, ethylcellulose (EC), and povidone (PVP) were developed and evaluated for the potential drug delivery using depilated freshly excised abdominal ..
  6. ncbi Enhanced neuroprotective effects of resveratrol delivered by nanoparticles on hydrogen peroxide-induced oxidative stress in rat cortical cell culture
    Xiaowei Lu
    Department of Geriatrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, P R China
    Mol Pharm 10:2045-53. 2013
    ..RES-NPs could be a potential treatment needing intensive research for ischemia/reperfusion related disorder including stroke...
  7. ncbi Paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) nanoparticles: preparation and antitumor activity in vivo
    Zhenshu Zhu
    Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, PR China
    J Control Release 142:438-46. 2010
    ....
  8. ncbi A comparison between povidone-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation
    Biswajit Mukherjee
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata Calcutta, India
    Eur J Pharm Biopharm 59:475-83. 2005
    ..transdermal drug delivery system (TDDS) of dexamethasone using blends of two different polymeric combinations, povidone (PVP) and ethylcellulose (EC) and Eudragit with PVP...
  9. ncbi The use of PVP as a polymeric carrier to improve the plasma half-life of drugs
    Yoshihisa Kaneda
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 25:3259-66. 2004
    ..However, PVP showed the minimum volume of tissue distribution. These results suggested that PVP is the most suitable polymeric modifier for prolonging the circulation lifetime of a drug and localizing the conjugated drug in blood...
  10. pmc Use of magnetically purified Plasmodium falciparum parasites improves the accuracy of erythrocyte invasion assays
    Adam H Bates
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Parasitol 126:278-80. 2010
    ..The magnetic purification method is an excellent alternative for parasite isolates that do not tolerate or with unknown sensitivity to Percoll-sorbitol exposure...
  11. ncbi Anaphylaxis to polyvinylpyrrolidone in povidone-iodine for impetigo contagiosum in a boy with atopic dermatitis
    Koichi Yoshida
    Department of Pediatrics, Nara Medical University School of Medicine, Kashihara, Japan
    Int Arch Allergy Immunol 146:169-73. 2008
    b>Povidone-iodine (PVP-I) is widely used in antiseptic agents. Immediate allergic reaction to PVP-I preparations is very rare and often overlooked, as it is difficult to diagnose...
  12. ncbi Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel Chlorin e6 photosensitizer Fotolon
    Bhuvaneswari Ramaswamy
    Division of Medical Sciences, National Cancer Centre Singapore, Singapore 169610
    Int J Oncol 26:1501-6. 2005
    ..The tumour to normal tissue selectivity ratio was highest at 6 h. The microfluorescence tumour imaging shows similar trends confirming the macroscopic fluorescence data. Fotolon shows much promise as a good photodiagnostic agent...
  13. ncbi Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model
    William Wei Lim Chin
    Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore
    Cancer Lett 245:127-33. 2007
    ..In conclusion, the Ce6-PVP formulation appeared to have the potential as a fluorescent marker for fluorescence diagnosis of human bladder cancer...
  14. ncbi Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone
    William Wei Lim Chin
    Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore
    J Photochem Photobiol B 84:103-10. 2006
    ..This eliminates the need for long-term photosensitivity precautions. In conclusion, the Ce6-PVP formulation seems to be a promising photosensitizer for fluorescence imaging as well as for photodynamic treatment...
  15. ncbi Integrated morphophysiological assessment of two methods for sperm selection in bovine embryo production in vitro
    A Cesari
    Instituto de Investigaciones Biologicas, Facultad de Ciencias Exactas y Naturales, UNMdP CC 1245 7600 Mar del Plata, Buenos Aires, Argentina
    Theriogenology 66:1185-93. 2006
    ....
  16. ncbi Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients
    S Nazzal
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Technical University Health Science Center, Amarillo, TX 79106, USA
    Int J Pharm 240:103-14. 2002
    ..6, 560.1 and 100, respectively. A new formulation was prepared according to these levels. The observed responses were in close agreement with the predicted values of the optimized formulation...
  17. ncbi Polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions
    Patricia C Buchsel
    Seattle University College of Nursing, 18503 SE 64th Way, Issaquah, WA 98027, USA
    Expert Opin Drug Metab Toxicol 4:1449-54. 2008
    ..Small studies have been done in healing oral lesions arising from laser surgery and in wound healing but research is needed to support the use of polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair) in these clinical setting...
  18. ncbi Effect of Percoll volume, duration and force of centrifugation, on in vitro production and sex ratio of bovine embryos
    G M Machado
    Embrapa Recursos Genéticos e Biotecenologia Laboratório de Reprodução Animal Parque Estação Biológica W5 Final Norte, Brasília 70770 900, DF, Brazil
    Theriogenology 71:1289-97. 2009
    ..In conclusion, decreasing Percoll volume, reducing duration of centrifugation, and using a higher force of centrifugation did not significantly affect sperm quality, embryo development, or sex ratio of in vitro-produced bovine embryos...
  19. ncbi Outcome of sperm preparation using double-gradients technique study in Siriraj Hospital
    Somsin Petyim
    Infertility Unit, Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand
    J Med Assoc Thai 92:878-84. 2009
    ..To determine the succession of sperm preparation using the double-gradients technique on sperm quality: sperm recovery rate, sperm concentration, sperm motility and percentage of post wash total motile sperm count...
  20. ncbi Effect of swim up and Percoll treatment on viability and acrosome integrity of frozen-thawed bull spermatozoa
    T Somfai
    University of West Hungary, Institute of Animal Breeding, Mosonmagyaróvár, Hungary
    Reprod Domest Anim 37:285-90. 2002
    ..Therefore the use of Percoll-treated spermatozoa in IVF systems can be more expedient...
  21. pmc Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts
    William W L Chin
    Division of Medical Sciences, 11 Hospital Drive, Singapore 169610, National Cancer Centre, Singapore
    BMC Pharmacol 7:15. 2007
    ..The present study evaluated the potential use of chlorin e6 - polyvinylpyrrolidone (Ce6-PVP) as a multimodality photosensitizer for fluorescence detection and photodynamic therapy (PDT) on NSCLC and SCLC xenografts...
  22. ncbi HPLC study of chlorin e6 and its molecular complex with polyvinylpyrrolidone
    H A Isakau
    Scientific Pharmaceutical Center, RUE Belmedpreparaty, Fabritsius Str 30, 220007 Minsk, Belarus
    Biomed Chromatogr 21:318-25. 2007
    ..The method was specific, accurate and precise, allowing the analysis of chlorin e(6) in the presence of numerous degradation products useful in the manufacturing process and quality control of chlorin e(6) and Photolon...
  23. ncbi The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy
    William Wei Lim Chin
    Division of Medical Sciences, National Cancer Centre Singapore, 11 Hospital Drive, 169610, Singapore
    Photochem Photobiol Sci 5:1031-7. 2006
    ..A faster clearance rate of Ce6-PVP from the skin of nude mice was observed compared to Ce6. The new formulation of Ce6-PVP seems to show promise as an effective therapeutic agent...
  24. ncbi Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer
    William Wei Lim Chin
    Division of Medical Sciences, National Cancer Centre Singapore, Singapore
    Eur J Pharm Biopharm 69:1083-93. 2008
    ..No serious adverse events were observed in human as well...
  25. ncbi Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy
    Patricia S P Thong
    Division of Medical Sciences, National Cancer Centre, Singapore
    J Environ Pathol Toxicol Oncol 27:35-42. 2008
    ..Specifically, lower fluence rate PDT appears to activate the body's immune response against untreated lesions...
  26. ncbi HPLC detection of plasma concentrations of diclofenac in human volunteers administered with povidone-ethylcellulose-based experimental transdermal matrix-type patches
    B Mukherjee
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India
    Methods Find Exp Clin Pharmacol 28:301-6. 2006
    ..blood concentrations of diclofenac in human volunteers administered with the transdermal patches prepared with povidone-ethylcellulose and oral diclofenac tablets. Drug-excipient interaction studies were done using the FTIR technique...
  27. ncbi Fractionation of cells and subcellular particles with Percoll
    H Pertoft
    Department of Medical Biochemistry and Microbiology, Unit of Biochemistry, University of Uppsala BMC, Box 575, SE 75123, Uppsala, Sweden
    J Biochem Biophys Methods 44:1-30. 2000
    ..Furthermore, since Percoll media are inert, they are well suited for the separation of fragile elements like enveloped viruses...
  28. ncbi Spectroscopic and kinetic studies on the interaction of ketoconazole and povidone drugs with DDQ
    M Pandeeswaran
    Department of Chemistry, Gandhigram Rural University, Gandhigram 624302, India
    Spectrochim Acta A Mol Biomol Spectrosc 69:1082-8. 2008
    ..and mechanism of the interaction between 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and ketoconazole and povidone drugs has been investigated spectroscopically...
  29. ncbi Dissolution and precipitation behavior of amorphous solid dispersions
    David E Alonzo
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    J Pharm Sci 100:3316-31. 2011
    ..The supersaturation generated upon dissolution of the solid dispersions was maintained for biologically relevant timeframes for the HPMC dispersions, whereas PVP appeared to be a less effective crystallization inhibitor...
  30. ncbi Preparation and in vitro evaluation of povidone-sodium cholate-phospholipid mixed micelles for the solubilization of poorly soluble drugs
    Yuan Zhu
    Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, 212013, China
    Arch Pharm Res 33:911-7. 2010
    ..1 h. Our results suggest that these mixed micelles might have significant potential application to the biomedical field...
  31. ncbi Comparing pain control and ability to eat and drink with standard therapy vs Gelclair: a preliminary, double centre, randomised controlled trial on patients with radiotherapy-induced oral mucositis
    Claire Barber
    RD and E NHS Foundation Trust, Barrack Rd, Exeter, Devon, EX2 5DW, UK
    Support Care Cancer 15:427-40. 2007
    ..The aim of this randomised-controlled trial was to evaluate the efficacy of Gelclair, as compared to standard therapy, as a means of short-term symptom control for patients suffering from radiotherapy-induced OM...
  32. ncbi Toward understanding the high PDT efficacy of chlorin e6-polyvinylpyrrolidone formulations: photophysical and molecular aspects of photosensitizer-polymer interaction in vitro
    H A Isakau
    Scientific Pharmaceutical Center, RUE Belmedpreparaty, Fabritsius Street 30, 220007 Minsk, Belarus
    J Photochem Photobiol B 92:165-74. 2008
    ..Possible scenarios of how the presence of PVP can favorably affect the PDT efficacy of chlorin e6 in Ce6-PVP formulations are discussed...
  33. ncbi Anaphylaxis to povidone in a child
    C Pedrosa
    Paediatric Allergy Unit, Gaia Hospital, Gaia, Portugal
    Pediatr Allergy Immunol 16:361-2. 2005
    b>Povidone is an allergic agent present in numerous substances, food and medicines...
  34. ncbi Improving the dissolution rate of poorly water soluble drug by solid dispersion and solid solution: pros and cons
    Rina J Chokshi
    Applied Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
    Drug Deliv 14:33-45. 2007
    ..Therefore, considering physical stability and in vivo study results, the solid dispersion was the most suitable choice to improve dissolution rates and hence the bioavailability of the poorly water soluble drug...
  35. ncbi Sustained release pellets based on poly(N-isopropyl acrylamide): matrix and in situ photopolymerization-coated systems
    Marcos Mayo-Pedrosa
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    J Pharm Sci 96:93-105. 2007
    ..In situ formation and cross-linking of PNIPA on the pellet appears as a feasible way for controlling drug release...
  36. ncbi Investigation of excipient and processing on solid phase transformation and dissolution of ciprofloxacin
    Xianwen Li
    Department of Chemistry and Chemical Engineering, Minjiang University, No 1 Wenxian Road, Shangjie Town, Minhou County, Fuzhou, Fujian 350108, PR China
    Int J Pharm 328:177-82. 2007
    ....
  37. ncbi Stable carbamazepine colloidal systems using the cosolvent technique
    D Douroumis
    Department of Pharmaceutical Technology, University of Jena, Lessingstrasse 8, D 07743 Jena, Germany
    Eur J Pharm Sci 30:367-74. 2007
    ..Suspension stability was evaluated over 5 months where the particle size remained constant. FT-Raman studies showed the existence of form I within the stable CBZ suspensions...
  38. ncbi Characterization and taste-masking evaluation of acetaminophen granules: comparison between different preparation methods in a high-shear mixer
    Beatrice Albertini
    Department of Pharmaceutical Sciences, University of Bologna, Via S Donato 19 2, 40127, Bologna, Italy
    Eur J Pharm Sci 21:295-303. 2004
    ..In conclusion, the steam granulation technique resulted a suitable method to comply the purpose of this work, without modifying the availability of the drug...
  39. ncbi Development of starch-based pellets via extrusion/spheronisation
    Aleksandra Dukić
    Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium
    Eur J Pharm Biopharm 66:83-94. 2007
    ..2), low friability (<0.01%), fast disintegration (<10 min) and complete drug release in less than 20 min for all formulations, demonstrated the potential of this modified starch in formulations intended for extrusion/spheronisation...
  40. ncbi Enhancement of dissolution rate of valdecoxib using solid dispersions with polyethylene glycol 4000
    Chengsheng Liu
    Life Science College, Ocean University of China, Qingdao, China
    Drug Dev Ind Pharm 31:1-10. 2005
    ..The SEM pictures showed the formation of effective SDs of valdecoxib with PEG 4000, since well-defined changes in the surface nature of valdecoxib, SDs, and physical mixture were observed...
  41. ncbi Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling
    James E Patterson
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Int J Pharm 336:22-34. 2007
    ..The dissolution of the spray-dried material was generally poor, compared to melt extruded and ball milled products. This was probably due to rapid dissolution of PVP from the small particles of the spray-dried products...
  42. ncbi Comparative effects of some hydrophilic excipients on the rate of gabapentin and baclofen lactamization in lyophilized formulations
    Annalisa Cutrignelli
    Dipartimento Farmaco Chimico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
    Int J Pharm 332:98-106. 2007
    ..Water may provide a favourable environment for degradation. These findings, taken together, should be considered during the selection of excipients for a possible formulation of gabapentin and baclofen...
  43. ncbi Ibuprofen extrudate, a novel, rapidly dissolving ibuprofen formulation: relative bioavailability compared to ibuprofen lysinate and regular ibuprofen, and food effect on all formulations
    Matthias Klueglich
    Human Pharmacology Centre Ingelheim, Boehringer Ingelheim Pharma GmbH and Co KG, Biberach an der Riss, Germany
    J Clin Pharmacol 45:1055-61. 2005
  44. ncbi Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000
    Nora Anne Urbanetz
    Institut für Pharmazeutische Technologie und Biopharmazie, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Eur J Pharm Sci 28:67-76. 2006
    ..polyacrylic acid, polyvinyl alcohol and povidone K17 were included in the study...
  45. ncbi Spray drying for generation of a ternary amorphous system of celecoxib, PVP, and meglumine
    Piyush Gupta
    Department of Pharmaceutical Technology Formulations, National Institute of Pharmaceutical Education and Research NIPER, Punjab, India
    Pharm Dev Technol 10:273-81. 2005
    ..This technique can serve as a suitable means for generating a ready-to-formulate amorphous drug-additive(s) composite that can be directly filled into hard gelatin capsules...
  46. ncbi HyperDSC studies of amorphous polyvinylpyrrolidone in a model wet granulation system
    Graham Buckton
    Department of Pharmaceutics, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Int J Pharm 312:61-5. 2006
    ..We believe that this is the first measurement of in situ properties of a binder in this way and opens the possibility of studies on formulated systems...
  47. ncbi Stability study of amorphous valdecoxib
    Anshuman A Ambike
    Department of Pharmaceutics, Poona College of Pharmacy and Research Center, Bharati Vidyapeeth Deemed University, Erandwane, Pune 411038, Maharashtra, India
    Int J Pharm 282:151-62. 2004
    ..The study thus definitely reveals tremendous potential of solid dispersions of valdecoxib with PVP, from stability point of view...
  48. ncbi Solid state and dissolution rate characterization of co-ground mixtures of nifedipine and hydrophilic carriers
    H Friedrich
    College of Pharmacy, Freie Universitat Berlin, Kelchstrasse 31, Berlin, Germany
    Drug Dev Ind Pharm 31:719-28. 2005
    ..Differential scanning calorimetry (DSC) measurements gave valuable information about the nature of drug crystallinity and the interactions with the carriers within the ground mixtures...
  49. ncbi The influence of granulation on super disintegrant performance
    Na Zhao
    Univeristy of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    Pharm Dev Technol 11:47-53. 2006
    ..Due to the size increase following granulation, a higher addition level of super disintegrant is required to ensure fast and uniform disintegration of tablets prepared by granulation...
  50. ncbi Fluidity and tableting characteristics of a powder solid dispersion of the low melting drugs ketoprofen and ibuprofen with crospovidone
    Yusuke Shibata
    Showa Pharmaceutical University, 3 3165 Higashi Tamagawagakuen, Machida, Tokyo, 194 8543, Japan
    Drug Dev Ind Pharm 32:449-56. 2006
    ..However, addition of 1% MS, lowered the SP value and eliminated sticking. Thus, an SD of compounds with a low melting point such as KP or IP is suitable for tablet manufacture by direct compression with the addition of 1% MS...
  51. ncbi Spray-dried amorphous solid dispersions of simvastatin, a low tg drug: in vitro and in vivo evaluations
    Anshuman A Ambike
    Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, 411 038, Maharashtra, India
    Pharm Res 22:990-8. 2005
    ....
  52. ncbi Development of a single unit extended release formulation for ZK 811 752, a weakly basic drug
    H Kranz
    Pharmaceutical Development, Schering AG, D 13342 Berlin, Germany
    Eur J Pharm Sci 26:47-53. 2005
    ..An extended release matrix tablet for ZK 811 752 consisting of drug, polymer and organic acid providing the desired pH-independent drug release has been developed...
  53. ncbi Stability and solubility of celecoxib-PVP amorphous dispersions: a molecular perspective
    Piyush Gupta
    Department of Pharmaceutical Technology Formulations, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, Phase X, SAS Nagar, Punjab 160 062, India
    Pharm Res 21:1762-9. 2004
    ....
  54. ncbi Formulation of solid dosage forms to overcome gastric pH interaction of the factor Xa inhibitor, BMS-561389
    Sherif I Farag Badawy
    Pharmaceutical Research Institute, Bristol Myers Squibb Co, One Squibb Drive, New Brunswick, New Jersey 08903, USA
    Pharm Res 23:989-96. 2006
    ....
  55. ncbi Formulation and characterisation of tetracycline-containing bioadhesive polymer networks designed for the treatment of periodontal disease
    David S Jones
    School of Pharmacy, The Queen s University of Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK
    Curr Drug Deliv 1:17-25. 2004
    ..Based on the drug release, rheological and textural properties, it is suggested that the formulation containing 15% w/w PMVE-MA, 6% w/w PVP and tetracycline hydrochloride (5% w/w) may be useful for the treatment of periodontal disease...
  56. ncbi In vitro-in vivo characterization of release modifying agents for parenteral sustained-release ketorolac formulation
    V Puri
    Department of Pharmaceutical Technology Formulations, National Institute of Pharmaceutical Education and Research, SAS Nagar, Punjab, India
    Drug Dev Ind Pharm 30:619-26. 2004
    ..Glyceryl monooloeate-based formulation produced the most favorable drug blood concentration vs. time profile...
  57. ncbi Evaluation of hydroperoxides in common pharmaceutical excipients
    Walter R Wasylaschuk
    Pharmaceutical Analysis Chemistry, Merck Research Laboratories, Merck and Co, Inc, P O Box 4, WP78 210, West Point, PA 19486, USA
    J Pharm Sci 96:106-16. 2007
    ..b>Povidone, polysorbate 80 (PS80), polyethylene glycol (PEG) 400, and hydroxypropyl cellulose (HPC) were found to contain ..
  58. ncbi Influence of Eudragit NE 30 D blended with Eudragit L 30 D-55 on the release of phenylpropanolamine hydrochloride from coated pellets
    Weijia Zheng
    College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Drug Dev Ind Pharm 29:357-66. 2003
    ..The presence of Eudragit L 30 D-55 also produced a film coating that was less tacky, and a dispersion of Eudragit NE 30 D containing Eudragit L 30 D-55 (5:1) was shown to prevent agglomeration of the pellets during coating and storage...
  59. pmc Comparison of the effect of tromethamine and polyvinylpyrrolidone on dissolution properties and analgesic effect of nimesulide
    Hamdy Abdelkader
    Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt
    AAPS PharmSciTech 8:E65. 2007
    ..Thus, the solubilizing power, dissolution-enhancing effect, and analgesic effect enhancer ability toward the drug make Tris particularly suitable for developing a reduced-dose, fast-release solid oral dosage form of nimesulide...
  60. ncbi The potential of small-scale fusion experiments and the Gordon-Taylor equation to predict the suitability of drug/polymer blends for melt extrusion
    A Forster
    School of Pharmacy, University of Otago, New Zealand
    Drug Dev Ind Pharm 27:549-60. 2001
    ..The use of beaker melts allows a conservative estimate of the potential to melt extrude a drug. To predict physical stability, analysis of the Tg must be combined with physical stability experiments...
  61. ncbi pH-independent drug release of an extremely poorly soluble weakly acidic drug from multiparticulate extended release formulations
    Therese Riis
    Pharmaceutical Development, Schering AG, Berlin, Germany
    Eur J Pharm Biopharm 65:78-84. 2007
    ..Compound release from mini matrix tablets prepared by wet granulation was faster compared to the drug release from tablets prepared by direct compression...
  62. ncbi Subcoating with Kollidon VA 64 as water barrier in a new combined native dextran/HPMC-cetyl alcohol controlled release tablet
    Eddy Castellanos Gil
    Center of Pharmaceutical Chemistry CQF, Havana, Cuba
    Eur J Pharm Biopharm 69:303-11. 2008
    ..capsule) for initial time, one year and 2 two years, respectively) suggested that the dissolution profiles of the present three sustained-release oral dosage forms are similar and stable during two years under stability condition...
  63. ncbi Preparation of bilayer-core osmotic pump tablet by coating the indented core tablet
    Longxiao Liu
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China
    Int J Pharm 352:225-30. 2008
    ..It might be promising in the field of preparation of bilayer-core OPT...
  64. ncbi Formulation and characterization of ternary solid dispersions made up of Itraconazole and two excipients, TPGS 1000 and PVPVA 64, that were selected based on a supersaturation screening study
    Sandrien Janssens
    Laboratorium voor Farmacotechnologie en Biofarmacie, Catholic University of Leuven, Leuven, Belgium
    Eur J Pharm Biopharm 69:158-66. 2008
    ..The precipitation after 1h, however, is probably due to the combination of the surfactant properties of TPGS and the small crystalline Itraconazole fraction...
  65. pmc Improved dissolution of oleanolic acid with ternary solid dispersions
    Longxiao Liu
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China
    AAPS PharmSciTech 8:E113. 2007
    ..Moreover, the dissolution of ternary solid dispersion was faster compared with that of binary solid dispersion. Polysorbate 80 played an important positive role in dissolution of the solid dispersion...
  66. ncbi Solid-state interaction of stearic acid with povidone and its effect on dissolution stability of capsules
    D Desai
    Bristol Myers Squibb Co, PO Box 191, New Brunswick, NJ 08903 0191, United States
    Int J Pharm 354:77-81. 2008
    ..The formulations of both drugs contained povidone as a binder and stearic acid as a lubricant...
  67. ncbi Process and formulation characterizations of the thermal adhesion granulation (TAG) process for improving granular properties
    Hong Liang Lin
    College of Pharmacy, Taipei Medical University, Taipei, Taiwan, ROC
    Int J Pharm 357:206-12. 2008
    ....
  68. ncbi Solid dispersions of dihydroartemisinin in polyvinylpyrrolidone
    Muhammad Tayyab Ansari
    Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan Post Code 60800, Pakistan
    Arch Pharm Res 31:390-8. 2008
    ..e. dielectric constant, dipole moment and structure, influenced the amount of amorphousness and related properties of dihydroartemisinin...
  69. pmc Synthesis and characterization of pectin/PVP hydrogel membranes for drug delivery system
    Rakesh K Mishra
    Department of Polymer Science, Bundelkhand University, Jhansi 284128, India
    AAPS PharmSciTech 9:395-403. 2008
    ..It was found that tensile strength increases with increasing PVP ratios in the hydrogel membranes. The prepared hydrogel membranes were found to be biocompatible with B16 melanoma cells...
  70. pmc Comparative study of propranolol hydrochloride release from matrix tablets with KollidonSR or hydroxy propyl methyl cellulose
    J Sahoo
    Royal College of Pharmacy and Health Sciences, Andhapasara Road, Berhampur 760002, Orissa, India
    AAPS PharmSciTech 9:577-82. 2008
    ..In conclusion, the in vitro release profile and the mathematical models indicate that release of propranolol hydrochloride can be effectively controlled from a single tablet using HPMC K15M or KollidonSR matrix system...
  71. ncbi Preparation, characterization and in vitro evaluation of solid dispersions containing docetaxel
    Jie Chen
    College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People s Republic of China
    Drug Dev Ind Pharm 34:588-94. 2008
    ..These results show that solid dispersion is a promising approach of developing docetaxel drug formulates...
  72. ncbi Formulation of fast disintegrating tablets of ternary solid dispersions consisting of TPGS 1000 and HPMC 2910 or PVPVA 64 to improve the dissolution of the anti-HIV drug UC 781
    Caroline Goddeeris
    Laboratory of Pharmacotechnology and Biopharmacy, Catholic University of Leuven, O and N2, 9 921, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Pharm Sci 34:293-302. 2008
    ..Amorphous TPGS 1000 clusters occurred in PVPVA 64 and HPMC 2910 formulations upon addition of at least 10% (w/w) UC 781, showing extremely low glass transition temperatures depending of the thermal history of the samples...
  73. ncbi Raman and thermal analysis of indomethacin/PVP solid dispersion enteric microparticles
    Adamo Fini
    Dipartimento SMETEC, University of Bologna, Via San Donato 15, Bologna, Italy
    Eur J Pharm Biopharm 70:409-20. 2008
    ..Finally, the coating with stearic acid is discussed as a determining process for the practical application of solid dispersions...
  74. ncbi Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30
    Pia Thybo
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Pharm Dev Technol 13:375-86. 2008
    ..The stabilizing effect of the polymer was verified in the solid state, as all the SDs retained probucol in the amorphous state throughout the entire length of the stability study...
  75. ncbi Stabilization of low glass transition temperature indomethacin formulations: impact of polymer-type and its concentration
    Rina J Chokshi
    Applied Pharmaceutical Sciences, University of Rhode Island, Kingston, Rhode Island, USA
    J Pharm Sci 97:2286-98. 2008
    ..The presence of specific molecular interactions between INM and EPO was also shown by the antiplasticization effect...
  76. ncbi Development of spray-dried co-precipitate of amorphous celecoxib containing storage and compression stabilizers
    Ravindra S Dhumal
    Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy and Research Centre, Erandawane, Pune 411038 Maharashtra, India
    Acta Pharm 57:287-300. 2007
    ..The present study demonstrates the synergistic effect of combining two types of stabilizers, PVP and CAR, on the stability of amorphous drug during compression and storage as compared to their effect when used alone...
  77. ncbi Sudden rise of crystal growth rate of nifedipine near T(g) without and with polyvinylpyrrolidone
    Hajime Ishida
    School of Pharmacy, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Pharm Sci 96:1131-8. 2007
    ..The presence of 1% or 2% PVP had little effect on the growth rate near T(g) + 50 K, but reduced the growth rate by 100-fold at T(g) + 9 K. These kinetic features are relevant to predicting the stability of amorphous drugs...
  78. ncbi Increasing the aqueous solubility of acetaminophen in the presence of polyvinylpyrrolidone and investigation of the mechanisms involved
    H Afrasiabi Garekani
    School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
    Drug Dev Ind Pharm 29:173-9. 2003
    ..Therefore, the increase in solubility of acetaminophen in the presence of PVP is probably attributed to its ability to form a water-soluble complex with PVP...
  79. ncbi Modified release of coated sugar spheres using drug-containing polymeric dispersions
    Tae Wan Kim
    National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University, Chuncheon 200 701, Korea
    Arch Pharm Res 30:124-30. 2007
    ..The solubilization and controlled release of poorly water-soluble drugs can be achieved as both the solubilizers and drugs are present in the drug-containing polymeric dispersions...
  80. ncbi Investigating the effects of excipients on the powder flow characteristics of theophylline anhydrous powder formulations
    Karen M Nagel
    Department of Industrial and Physical Pharmacy, Purdue University School of Pharmacy, West Lafayette, Indiana, USA
    Drug Dev Ind Pharm 29:277-87. 2003
    ..The effect of each component on powder flow is discussed...
  81. ncbi Processing-induced phase transitions of theophylline--implications on the dissolution of theophylline tablets
    Jaidev S Tantry
    Department of Pharmaceutics, College of Pharmacy, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, USA
    J Pharm Sci 96:1434-44. 2007
    ....
  82. ncbi Evaluation of the disintegration time of rapidly disintegrating tablets via a novel method utilizing a CCD camera
    Yutaka Morita
    EMP R and D Section, Eisai Co, Ltd, Honjo, Saitama, Japan
    Chem Pharm Bull (Tokyo) 50:1181-6. 2002
    ..e., morphological changes in the tablet during disintegration. This method is useful for the evaluation of the disintegration of RDT during pharmaceutical development, and also for quality control during production...
  83. ncbi Physicochemical characterization and dissolution study of solid dispersions of Lovastatin with polyethylene glycol 4000 and polyvinylpyrrolidone K30
    R P Patel
    Department of Pharmaceutics, S K Patel College of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar, Kherva, Gujarat, India
    Pharm Dev Technol 12:21-33. 2007
    ..Tablets containing solid dispersion prepared with PEG and PVP showed significant improvement in the release profile Lovastatin compared with tablets containing Lovastatin without PEG or PVP...
  84. ncbi Processing of nimesulide-PEG 400-PG-PVP solid dispersions: preparation, characterization, and in vitro dissolution
    M C Gohel
    Pharmaceutics and Pharmaceutical Technology Department, L M College of Pharmacy, Navarangpura, Ahmedabad, India
    Drug Dev Ind Pharm 29:299-310. 2003
    ..Significant improvement in drug dissolution was observed (Q120 = 70%), compared with pure drug powder (Q120 = 15%). In conclusion, dissolution of nimesulide can be modulated using an appropriate blend of pharmaceutical adjuvants...
  85. ncbi Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)
    Yousef Javadzadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
    Int J Pharm 341:26-34. 2007
    ..The results of DSC and X-ray crystallography did not show any changes in crystallinity of the drug and interaction between carbamazepine and exipients during the process...
  86. ncbi Improved bioavailability of aceclofenac from spherical agglomerates: development, in vitro and preclinical studies
    S Muatlik
    Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal 576104, Karnataka State, India
    Pak J Pharm Sci 20:218-26. 2007
    ..These optimized agglomerates showed rapid analgesic and anti-inflammatory activity besides exhibiting improved bioavailability of drug when compared to pure drug...
  87. ncbi Modulation of drug release kinetics from hydroxypropyl methyl cellulose matrix tablets using polyvinyl pyrrolidone
    Ian J Hardy
    Pharmaceutical Research and Development, Merck Sharp and Dohme Ltd, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, United Kingdom
    Int J Pharm 337:246-53. 2007
    ..A validated mathematical model is also presented which allows drug release profiles to be reliably predicted based on the initial HPMC and PVP content in the tablet...
  88. ncbi Fast disintegrating tablets containing Rhodiola rosea L. extract
    Agne Kucinskaite
    Department of Pharmaceutical Technology and Social Pharmacy, Kaunas University of Medicine, A Mickeviciaus 9, 44307 Kaunas, Lithuania
    Acta Pol Pharm 64:63-7. 2007
    ..The tablets containing microcrystalline cellulose as a filler, povidone as a binder and crospovidone as a disintegrant were stable during 6 months storage at 25 degrees C/60% RH, ..
  89. ncbi Formulation design of carbamazepine fast-release tablets prepared by melt granulation technique
    Beatrice Perissutti
    Department of Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy
    Int J Pharm 256:53-63. 2003
    ..Moreover, the extragranular addition of a small amount of crospovidone gave rise to a further amelioration of the disintegration and dissolution performances...
  90. ncbi Comparison of the effects of commonly used wound agents on epithelialization and neovascularization
    D Kjolseth
    Division of Plastic and Reconstructive Surgery, University of Louisville, KY 40292
    J Am Coll Surg 179:305-12. 1994
    ..topical wound agents (bacitracin, sodium hypochlorite, silver nitrate, silver sulfadiazine, mafenide acetate, and povidone-iodine) on epithelialization and neovascularization in noninfected wounds...
  91. ncbi Conservative management of necrotizing fascitis in children
    Ashish Wakhlu
    Department of Pediatric Surgery, King George Medical University, Lucknow 226 003, India
    J Pediatr Surg 41:1144-8. 2006
    ..This paper reports conservative management of 18 patients with NF with minimal morbidity and mortality...
  92. ncbi Thyroid hormone metabolism in pediatric cardiac patients treated by continuous povidone-iodine irrigation for deep sternal wound infection
    L Kovacikova
    Cardiac Intensive Care Unit, Children s University Hospital, Limbova 1, 833 40, Bratislava, Slovak Republic
    Eur J Cardiothorac Surg 21:1037-41. 2002
    The purpose of this study was to assess the influence of povidone-iodine mediastinal irrigation used for the treatment of deep sternal wound infection (DSWI) on thyroid function.
  93. ncbi Stability indicating validated HPLC method for quantification of levothyroxine with eight degradation peaks in the presence of excipients
    R B Shah
    Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, USA
    Int J Pharm 360:77-82. 2008
    ..The method was used in the presence of commonly used formulation excipients such as butylated hydroxyanisole, povidone, crospovidone, croscarmellose sodium, mannitol, sucrose, acacia, lactose monohydrate, confectionary sugar, ..
  94. ncbi ["Iodine allergy": point of view]
    P Dewachter
    Service d Anesthésie Réanimation Chirurgicale, CHU, Hopital Central, 29, Avenue du Marechal de Lattre de Tassigny, 54035 Nancy Cedex, France
    Ann Fr Anesth Reanim 24:40-52. 2005
    ..The aim of this literature review is to suggest a diagnostic and a preventive attitude in patients having presented an immediate hypersensitivity reaction due to an iodinated drug...
  95. ncbi Feasibility of interstitial CT lymphography using optimized iodized oil emulsion in rats
    Yong Eun Chung
    Department of Radiology, Yonsei University Health System, Seoul, Republic of Korea
    Invest Radiol 45:142-8. 2010
    ..To formulate an iodine-based contrast agent with an oil-in-water emulsion and to evaluate the feasibility of the agent for use as an interstitial computed tomographic (CT) lymphographic agent in a normal rat model...
  96. ncbi Preoperative skin preparation of the foot and ankle: bristles and alcohol are better
    David J Keblish
    Brigham Foot and Ankle Center, Faulkner Hospital, Boston, Massachusetts, USA
    J Bone Joint Surg Am 87:986-92. 2005
    ..gt;70% of aerobic bacterial cultures of specimens taken from the nail folds following skin preparation with povidone-iodine were positive...
  97. pmc Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico
    Marco A Ramirez-Ortiz
    Department of Ophthalmology, Hospital Infantil de Mexico Federico Gomez, Calle Doctor Marquez 162, Colonia Doctores, CP 06720, Mexico City, Mexico
    Br J Ophthalmol 91:1430-4. 2007
    To evaluate the effectiveness of 2.5% povidone-iodine eye drops (PIED) compared with ophthalmic chloramphenicol (OC) for preventing neonatal conjunctivitis.
  98. ncbi A study of comparison of efficacy and safety of talc and povidone iodine for pleurodesis of malignant pleural effusions
    Sibes Kumar Das
    Department of Respiratory Medicine, Calcutta National Medical College and Hospital, Kolkata 700014
    J Indian Med Assoc 106:589-90, 592. 2008
    ..The present study is to compare the effectiveness and safety of talc and povidone iodine as chemical agents for pleurodesis in patients of malignant pleural effusion...
  99. ncbi Antibiotic sensitivities of Streptococcus pneumoniae, viridans streptococci, and group A hemolytic streptococci isolated from the maxillary and ethmoid sinuses
    Erol Keles
    Department of Otolaryngology, Medicine Faculty of Firat University, Elazig, Turkey
    Kulak Burun Bogaz Ihtis Derg 16:18-24. 2006
    ....
  100. ncbi Evaluation of disinfected casts poured in gypsum with gum arabic and calcium hydroxide additives
    Khalid M Abdelaziz
    Department of Dental Materials, Faculty of Dentistry, Mansoura University, Egypt
    J Prosthet Dent 92:27-34. 2004
    ..Disinfection of stone casts is an important measure for the control of cross-contamination. Many approaches have been used to disinfect stone casts, but information regarding the accuracy of the resultant casts is limited...
  101. ncbi Quality control in chronic wound management: the role of local povidone-iodine (Betadine) therapy
    Judit Daroczy
    Department of Dermatology and Lymphology, St Stephan Hospital, Budapest, Hungary
    Dermatology 212:82-7. 2006
    ..Stasis dermatitis related to chronic venous insufficiency accompanied by infected superficial ulcers must be differentiated from erysipelas, cellulitis and contact eczema...

Research Grants10

  1. INTRAVAGINAL PRODUCTS EFFECT ON VAGINAL PHYSIOLOGY
    David Eschenbach; Fiscal Year: 1999
    ..spermicide containing nonoxynol-9, commonly used vaginal douche products, including one that contains povidone-iodine, the intravaginal instillation of hydrogen peroxide producing Lactobacillus, and menopause before and ..
  2. TREATING PERIODONTAL INFECTION: GLYCEMIC CONTROL
    George Taylor; Fiscal Year: 2002
    ..regimen that will be evaluated will include ultrasonic bacterial curettage, local antimicrobial treatment with povidone-iodine irrigation, and oral systemic antibiotics (doxycycline or metronidizole)...
  3. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..Topical biocides will include povidone iodine and chlorhexidine gluconate...
  4. Plasmalemma permeability and necroptosis: New targets for intracerebral hemo
    Michael J Whalen; Fiscal Year: 2013
    ..Completion of these Aims will establish necrosis as central to ICH, and may establish VA64 and necrostatins as novel therapies for ICH. ..
  5. Scientific Basis of Iodine-Fluoride Varnish in Preventing Dental Caries
    R MIKE SHIRTCLIFF; Fiscal Year: 2013
    ..of this Phase I application is to determine the technical and scientific feasibility of using a combination povidone-iodine (PVP-I)-5% sodium fluoride (NaF) varnish as a potential commercial product to prevent dental caries...
  6. Improving Clinical Outcomes for Early Chilhood Caries
    Robert Berkowitz; Fiscal Year: 2006
    ..Suppressing oral MS reservoirs with an anti-microbial agent is a promising approach. In this regard, 10% povidone iodine is approved as a presurgical disinfectant to the skin and mucous membranes of children and preliminary ..
  7. Suspended microchannels for biomolecular detection
    SCOTT MANALIS; Fiscal Year: 2005
    ..The suspended microchannels will also be useful for enabling point-of-care medical diagnostics. ..
  8. Integrated system for cancer biomarker detection
    SCOTT MANALIS; Fiscal Year: 2009
    ..The system will be batch fabricated by conventional foundry-level micromachining processes to enable widespread and low-cost distribution for point-of-care applications. ..
  9. Impact of adolescent pregnancy on nutritional status
    Joanne Katz; Fiscal Year: 2006
    ..Measures of nutritional status at birth include weight, length, head, chest and mid upper arm circumference. Growth of these infants through 6 months of age will also be examined, as will hemoglobin and serum retinol at 3 months of age. ..
  10. Artificial Cornea Based on Photolithographically Patterned, Biomimetic Hydrogels
    Christopher N Ta; Fiscal Year: 2010
    ..3. Determine the skirt design for optimal stromal tissue integration by evaluating in vitro and in vivo stromal wound healing within photolithographically patterned, microperforated hydrogel arrays. ..