polystyrenes

Summary

Summary: Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.

Top Publications

  1. ncbi Fabrication of polystyrene/gold nanotubes and nanostructure-controlled growth of aluminate
    Haifeng Zhu
    Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    J Nanosci Nanotechnol 7:2361-5. 2007
  2. ncbi Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:85-96. 2008
  3. ncbi Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line
    Oleg Lunov
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany
    ACS Nano 5:1657-69. 2011
  4. ncbi Cytotoxicity of nanoparticles independent from oxidative stress
    Eleonore Fröhlich
    Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
    J Toxicol Sci 34:363-75. 2009
  5. ncbi In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density
    W Zauner
    Cobra Therapeutics Ltd, The Science Park, Staffordshire, ST5 5SP, Keele, UK
    J Control Release 71:39-51. 2001
  6. ncbi Detection of malaria infection via latex agglutination assay
    Duangporn Polpanich
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Rd, Phyathai, Bangkok 10400, Thailand
    Anal Chem 79:4690-5. 2007
  7. pmc Culture of HepG2 liver cells on three dimensional polystyrene scaffolds enhances cell structure and function during toxicological challenge
    Maria Bokhari
    School of Biological and Biomedical Science, Durham University, South Road, Durham DH1 3LE, UK
    J Anat 211:567-76. 2007
  8. pmc Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines
    Tiago Dos Santos
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    PLoS ONE 6:e24438. 2011
  9. ncbi Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium
    K A Foster
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    J Pharm Pharmacol 53:57-66. 2001
  10. ncbi Surfactant-free purification of membrane proteins with intact native membrane environment
    Mohammed Jamshad
    School of Biosciences, University of Birmingham, U K
    Biochem Soc Trans 39:813-8. 2011

Detail Information

Publications251 found, 100 shown here

  1. ncbi Fabrication of polystyrene/gold nanotubes and nanostructure-controlled growth of aluminate
    Haifeng Zhu
    Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    J Nanosci Nanotechnol 7:2361-5. 2007
    ..The results demonstrate that the shape and size of the aluminates nanostructure can be controlled by etching time and the pore diameter of the alumina membrane...
  2. ncbi Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 2:85-96. 2008
    ..Taken together, the results of this study demonstrate the importance of cell-specific uptake mechanisms and pathways that could lead to sensitivity or resistance to cationic particle toxicity...
  3. ncbi Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line
    Oleg Lunov
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany
    ACS Nano 5:1657-69. 2011
    ....
  4. ncbi Cytotoxicity of nanoparticles independent from oxidative stress
    Eleonore Fröhlich
    Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
    J Toxicol Sci 34:363-75. 2009
    ..The mechanism of this damage includes apoptosis, necrosis and inhibition of proliferation...
  5. ncbi In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density
    W Zauner
    Cobra Therapeutics Ltd, The Science Park, Staffordshire, ST5 5SP, Keele, UK
    J Control Release 71:39-51. 2001
    ..Little correlation was found when the polyplex formulation was allowed to aggregate...
  6. ncbi Detection of malaria infection via latex agglutination assay
    Duangporn Polpanich
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Rd, Phyathai, Bangkok 10400, Thailand
    Anal Chem 79:4690-5. 2007
    ..The rapid agglutination-based latex particles assay developed herein showed a great potential for diagnosis of malaria infection...
  7. pmc Culture of HepG2 liver cells on three dimensional polystyrene scaffolds enhances cell structure and function during toxicological challenge
    Maria Bokhari
    School of Biological and Biomedical Science, Durham University, South Road, Durham DH1 3LE, UK
    J Anat 211:567-76. 2007
    ..This technology has potential applications for toxicity testing and drug screening...
  8. pmc Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines
    Tiago Dos Santos
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    PLoS ONE 6:e24438. 2011
    ..A strong reduction of NP uptake was observed after chlorpromazine treatment only in the case of 1321N1 cells. These outcomes suggested that the same NP might exploit different uptake mechanisms to enter different cell types...
  9. ncbi Microparticulate uptake mechanisms of in-vitro cell culture models of the respiratory epithelium
    K A Foster
    Department of Pharmaceutical Chemistry, University of Kansas, Lawrence 66047, USA
    J Pharm Pharmacol 53:57-66. 2001
    ..These results suggest that A549 and Calu-3 cells can internalize microspheres and that size and effective charge played an important role in the uptake process...
  10. ncbi Surfactant-free purification of membrane proteins with intact native membrane environment
    Mohammed Jamshad
    School of Biosciences, University of Birmingham, U K
    Biochem Soc Trans 39:813-8. 2011
    ....
  11. ncbi Solution-processed metallic conducting polymer films as transparent electrode of optoelectronic devices
    Yijie Xia
    Department of Materials and Engineering, National University of Singapore, Singapore
    Adv Mater 24:2436-40. 2012
    ..These PEDOT:PSS films with conductivity and transparency comparable to ITO can replace ITO as the transparent electrode of optoelectronic devices...
  12. ncbi The role of nanoparticle size in hemocompatibility
    Andrea Mayer
    Centre for Medical Research, Medical University of Graz, Stiftingtalstr 24, 8010 Graz, Austria
    Toxicology 258:139-47. 2009
    ..The size dependency of adverse effects in human blood is not linear; negatively charged particles larger than 60 nm hydrodynamic diameter appear to be considerably less hematotoxic than smaller ones...
  13. pmc Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells
    Marianne Geiser
    Institute for Anatomy, University of Bern, Bern, Switzerland
    Environ Health Perspect 113:1555-60. 2005
    ..Particles within cells are not membrane bound and hence have direct access to intracellular proteins, organelles, and DNA, which may greatly enhance their toxic potential...
  14. ncbi Wavelength-scale lens microscopy via thermal reshaping of colloidal particles
    Alexandru Vlad
    Institute of Information, Communication Technologies, Electronics and Applied Mathematics, Electrical Engineering, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Nanotechnology 23:285708. 2012
    ..We succeed in proper self-assembly of the colloidal lenses that enables large-area optical nanoscopy through simple and reliable experimental protocols. The limitations and the artifacts of the present technique are discussed...
  15. ncbi Stable nanoparticle aggregates/agglomerates of different sizes and the effect of their size on hemolytic cytotoxicity
    Justin M Zook
    Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA
    Nanotoxicology 5:517-30. 2011
    ..Finally, we demonstrate the importance of controlling agglomeration by showing that large agglomerates of silver nanoparticles cause significantly less hemolytic toxicity than small agglomerates...
  16. pmc The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice
    Rebecca M Sappington
    Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0654, USA
    Invest Ophthalmol Vis Sci 51:207-16. 2010
    ..Here the authors describe a novel and relatively simple method for inducing a highly consistent, modest, and repeatable elevation in IOP for rats and mice...
  17. ncbi SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours
    Khaled Greish
    Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    J Control Release 97:219-30. 2004
    ..v. administration of SMA-Dox micellar formulation can enhance the therapeutic effect of doxorubicin while reducing greatly cardiac and bone marrow toxicity, which should allow safe use of high doses of this agent...
  18. ncbi Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport
    Michelle Dawson
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Biol Chem 278:50393-401. 2003
    ....
  19. ncbi A novel method for encapsulation of poorly water-soluble drugs: precipitation in polyelectrolyte multilayer shells
    Igor Radtchenko
    Max Planck Institute of Colloid and Interfaces, 14424, Potsdam, Golm, Germany
    Int J Pharm 242:219-23. 2002
    ..Using capsules made of synthetic polyelectrolytes as a model system was demonstrated how to prepare, to measure and to use this gradient for low molecular weigh materials encapsulation...
  20. pmc Polystyrene nanoparticles activate ion transport in human airway epithelial cells
    J McCarthy
    School of Pharmacy and Pharmaceutical Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland
    Int J Nanomedicine 6:1343-56. 2011
    ..In this study, we investigated the acute effects of polystyrene nanoparticles on epithelial ion channel function...
  21. ncbi Serum heat inactivation affects protein corona composition and nanoparticle uptake
    Anna Lesniak
    Centre for BioNano Interactions, School of Chemistry and Chemical Biology, UCD Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Biomaterials 31:9511-8. 2010
    ..The fact that uptake was correlated with the amount of protein bound into the nanoparticle corona suggests the need for commonly agreed dispersion protocols for in vitro nanoparticle-cell studies...
  22. ncbi Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface
    C Heilmann
    Institut fur Medizinische Mikrobiologie, Munster, Germany
    Mol Microbiol 24:1013-24. 1997
    ..Our findings provide evidence for a new function of an autolysin (AtlE) in mediating the attachment of bacterial cells to a polymer surface, representing the prerequisite for biofilm formation...
  23. ncbi Cytotoxity of nanoparticles is influenced by size, proliferation and embryonic origin of the cells used for testing
    Eleonore Fröhlich
    Center for Medical Research, Medical University of Graz, A 8010 Graz, Austria
    Nanotoxicology 6:424-39. 2012
    ..Non-adherent cells, cells of mesenchymal origin and with high proliferation rate may be more susceptible to damage by nanoparticles...
  24. ncbi Ultrafine particles affect experimental thrombosis in an in vivo hamster model
    Abderrahim Nemmar
    Laboratory of Pneumology, Unit of Lung Toxicology, K U Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Respir Crit Care Med 166:998-1004. 2002
    ..The observed in vivo prothrombotic tendency results, at least in part, from platelet activation by positively charged amine-polystyrene particles...
  25. ncbi Online fluorescence suppression in modulated Raman spectroscopy
    Anna Chiara De Luca
    SUPA, School of Physics and Astronomy, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9SS, United Kingdom
    Anal Chem 82:738-45. 2010
    ....
  26. ncbi Reduced protein adsorption by osmolytes
    Florian Evers
    Fakultät Chemie, Technische Universität Dortmund, D 44221 Dortmund, Germany
    Langmuir 27:6995-7001. 2011
    ..The results of this study demonstrate that nonionic cosolvents can be used to tune and control nonspecific protein adsorption at aqueous-solid interfaces, which might be relevant for biomedical applications...
  27. ncbi Electrochemistry of conductive polymers. 45. Nanoscale conductivity of PEDOT and PEDOT:PSS composite films studied by current-sensing AFM
    Hyo Joong Lee
    Department of Chemistry, Pohang University of Science and Technology POSTECH, Pohang, 790 784, Korea, ROK
    J Phys Chem B 114:2660-6. 2010
    ..The conductivity of all these films was shown to be significantly enhanced by the electrochemical doping process...
  28. ncbi Sorption enhancement of lead ions from water by surface charged polystyrene-supported nano-zirconium oxide composites
    Qingrui Zhang
    Hebei Key Laboratory of Applied Chemistry, School of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, PR China
    Environ Sci Technol 47:6536-44. 2013
    ..Suitably charged functional groups in the hosts are crucial in the fabrication of efficient nanocomposites for the decontamination of water from toxic metals and other charged pollutants...
  29. ncbi Nitrate reduction using nanosized zero-valent iron supported by polystyrene resins: role of surface functional groups
    Zhenmao Jiang
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China
    Water Res 45:2191-8. 2011
    ..The results demonstrated that support chemistry plays a significant role in formation and reactivity of the encapsulated nZVI, and may shed new light on design and fabrication of hybrid nZVIs for environmental remediation...
  30. ncbi Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer
    Timothy J Knowles
    School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    J Am Chem Soc 131:7484-5. 2009
    ..They form 11 nm particles that are monodispersed, biocompatible, thermostable, and water-soluble, allowing diverse membrane proteins to be simply and rapidly presented for virtually any in vitro analysis...
  31. ncbi Fabrication of polymer-supported nanosized hydrous manganese dioxide (HMO) for enhanced lead removal from waters
    Qing Su
    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, PR China
    Sci Total Environ 407:5471-7. 2009
    ..All the results validated the feasibility of HMO-001 for highly effective removal of lead from contaminated waters...
  32. ncbi An excellent fluoride sorption behavior of modified amberlite resin
    Imam Bakhsh Solangi
    National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro 76080, Pakistan
    J Hazard Mater 176:186-92. 2010
    ..The study will contribute toward the remediation of fluoride polluted areas as well as in the various fields of materials science...
  33. ncbi Response of cells on surface-induced nanopatterns: fibroblasts and mesenchymal progenitor cells
    Hwei Ling Khor
    Max Planck Institute for Polymer Research, 10 Ackermannweg, 55128 Mainz, Germany
    Biomacromolecules 8:1530-40. 2007
    ..Atomic force microscopy showed that the cells remodelled the extracellular matrix differently as they migrate over the two distinctly different nanopatterns...
  34. ncbi Immobilization of antibodies on ultraflat polystyrene surfaces
    W Qian
    National Laboratory of Molecular and Biomolecular Electronics, Southeast University, Nanjing 210096, Peoples Republic of China
    Clin Chem 46:1456-63. 2000
    ....
  35. ncbi Enhancing Raman tweezers by phase-sensitive detection
    G Rusciano
    Dipartimento di Scienze Fisiche, Universita di Napoli Federico II, Complesso Universitario Monte S Angelo, Via Cinthia, I 80126 Napoli, Italy
    Anal Chem 79:3708-15. 2007
    ..Our results establish a direct and practical approach for background suppression in the spectroscopic analysis of optical trapped microsized samples...
  36. ncbi Enhanced photocatalytic hydrogen generation using polymorphic macroporous TaON
    Min Ying Tsang
    Department of Chemistry, University of York, Heslington, York, YO10 5DD UK
    Adv Mater 24:3406-9. 2012
    ..mac-TaON shows twice the activity for photocatalytic hydrogen generation in comparison to mac-TaON when normalised for surface area...
  37. ncbi Characterization of patocytosis: endocytosis into macrophage surface-connected compartments
    H S Kruth
    Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1422, USA
    Eur J Cell Biol 78:91-9. 1999
    ..Patocytosis is a unique endocytic process in macrophages triggered by small hydrophobic particles that provides a mechanism to sequester large amounts of these materials within a labyrinth of SCC...
  38. ncbi Specific selection for virulent urinary tract infectious Escherichia coli strains during catheter-associated biofilm formation
    Lionel Ferrières
    Microbial Adhesion Group, BioCentrum DTU, Technical University of Denmark, Lyngby, Denmark
    FEMS Immunol Med Microbiol 51:212-9. 2007
    ..Our results indicate that some silicone and silicone-latex catheters actually select for and promote biofilm formation of the most virulent group of UTI E. coli strains, hardly a desirable situation for the catheterized patient...
  39. ncbi Europium(III)-chelates embedded in nanoparticles are protected from interfering compounds present in assay media
    Leena Kokko
    Department of Biotechnology, University of Turku, Turku, Finland
    Anal Chim Acta 585:17-23. 2007
    ..Thus the Eu(III)-chelate dyed nanoparticles are preferred labels in homogeneous bioaffinity assays, when interfering compounds are known to be present...
  40. ncbi Influence of ionic interactions on the photoinduced birefringence of poly[1-[4-(3-carboxy-4 hydroxyphenylazo) benzene sulfonamido]-1,2-ethanediyl, sodium salt] films
    Quirina Ferreira
    CEFITEC, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829 516 Caparica, Portugal
    J Nanosci Nanotechnol 7:2659-66. 2007
    ..with poly(allylamine hydrochloride) (PAH), the electrostatic interactions between the oppositely charged polymers hampered photoisomerization and molecular rearrangement, thus leading to a slower writing kinetics for highly charged..
  41. ncbi Determination of degree of ionization of poly(allylamine hydrochloride) (PAH) and poly[1-[4-(3-carboxy-4 hydroxyphenylazo)benzene sulfonamido]-1,2-ethanediyl, sodium salt] (PAZO) in layer-by-layer films using vacuum photoabsorption spectroscopy
    Q Ferreira
    CEFITEC, Departamento de Fisica, Faculdade de Ciencias e Tecnologia, UNL, Campus de Caparica, 2829 516, Caparica, Portugal
    Langmuir 29:448-55. 2013
    ....
  42. ncbi Antibody-antigen interaction on polystyrene: an in situ ellipsometric study
    Olof Svensson
    Faculty of Health and Society, Malmo University, SE 205 06 Malmo, Sweden
    J Colloid Interface Sci 368:533-9. 2012
    ..A final set of experiments addressed the stability of adsorbed human IgG layers with respect to drying and incubation with surfactant. The results revealed that the adsorbed antibody layer is relatively resistant to these treatments...
  43. pmc Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles
    Maneerat Ekkapongpisit
    Laboratory of Molecular Pathology and Nanobioimaging, Department of Health Sciences, Universita del Piemonte Orientale A Avogadro, Novara, Italy
    Int J Nanomedicine 7:1829-40. 2012
    ..Mastocytes are also recruited in the tumor stroma and are involved in tumor vascularization and growth...
  44. ncbi Insecticide-treated nets against malaria vectors and polystyrene beads against Culex larvae
    Chris Curtis
    London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Trends Parasitol 21:504-7. 2005
    ..However, although polystyrene beads have been demonstrated to work extremely well, they have yet to be taken up on a major scale...
  45. ncbi Isolation and characterization of fluorescence-enhancing RNA tags
    Anna Wiesmayr
    Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany
    Bioorg Med Chem 19:1041-7. 2011
    ..This shift was accompanied by a 3.6-fold fluorescence enhancement of FlAsH fluorescence intensity. Mutation studies on the sequence revealed a rather robust structural motif...
  46. ncbi Temperature and pH-responsive properties of poly(styrene-co-maleic anhydride)-grafting poly(oxypropylene)-amines
    Jiang Jen Lin
    Institute of Polymer Science and Engineering, National Taiwan University, No 1, Sec 4, Roosevelt Rd, Taipei 10617, Taiwan
    J Colloid Interface Sci 336:82-9. 2009
    ..The responsiveness was correlated to the surface morphologies observed by tapping/phase mode atomic force microscopy (TM-AFM) on Mica film surface and also fluorescent properties in aqueous solution...
  47. ncbi Layer-by-layer coated digitally encoded microcarriers for quantification of proteins in serum and plasma
    Stefaan Derveaux
    Laboratory of General Biochemistry and Physical Pharmacy, University of Ghent, Harelbekestraat 72, 9000 Ghent, Belgium
    Anal Chem 80:85-94. 2008
    ..This paper also shows evidence that the LbL coated digitally encoded microcarriers are ideally suited for assaying proteins in "whole" blood in microfluidic chips, which are of high interest for "point-of-care" diagnostics...
  48. ncbi Layer-by-layer coating of degradable microgels for pulsed drug delivery
    B G De Geest
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    J Control Release 116:159-69. 2006
    ..Further, we show that the application of an LbL coating on the surface of the microgels dramatically lowers the burst release from the microcapsules and results in massive release at the time the microcapsules rupture...
  49. ncbi Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models
    Paul M van Midwoud
    Pharmaceutical Analysis, Department of Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Anal Chem 84:3938-44. 2012
    ..This paper lays an important foundation that will help researchers make informed decisions with respect to the materials they select for microfluidic cell-based culture experiments...
  50. ncbi Methods for nano-particle based vaccine formulation and evaluation of their immunogenicity
    Martha Kalkanidis
    Vaccine and Infectious Diseases Laboratory, Burnet Institute at Austin, Studley Road, Heidelberg, VIC 3084, Australia
    Methods 40:20-9. 2006
    ....
  51. ncbi BSA adsorption on differently charged polystyrene nanoparticles using isothermal titration calorimetry and the influence on cellular uptake
    Grit Baier
    Max Planck Institute for Polymer Research, Mainz, Germany
    Macromol Biosci 11:628-38. 2011
    ..The cellular uptake of particles before and after BSA adsorption was studied using HeLa cells in the presence and absence of supplemented FCS in the cell culture medium...
  52. pmc Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse
    Huihui Chen
    Department of Ophthalmology, Central South University, Changsha, Hunan, People s Republic of China
    Invest Ophthalmol Vis Sci 52:36-44. 2011
    ..To characterize a glaucoma model of mice, the authors adopted and modified a method of inducing the chronic elevation of intraocular pressure (IOP) by anterior chamber injection of polystyrene microbeads...
  53. ncbi Evaluating the uptake and intracellular fate of polystyrene nanoparticles by primary and hepatocyte cell lines in vitro
    Helinor J Johnston
    Biomedicine and Sport and Exercise Science Research Group, School of Life Sciences, Edinburgh Napier University, Edinburgh EH10 5DT, UK
    Toxicol Appl Pharmacol 242:66-78. 2010
    ..The findings were, in the main, comparable between primary rat hepatocytes and the different human hepatocyte cell lines...
  54. ncbi Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity
    Khaled Greish
    Division of Advanced Biomedical Sciences, Department of Microbiology, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860 8556, Japan
    Bioconjug Chem 16:230-6. 2005
    ..These data thus suggest that intravenous administration of the SMA-THP micellar formulation can enhance the therapeutic effect of pirarubicin more than 50-fold...
  55. ncbi Functional groups on polystyrene model nanoparticles: influence on protein adsorption
    Andrea Gessner
    Department of Pharmaceutics, Biopharmaceutics and Biotechnology, The Free University of Berlin, D 12169 Berlin, Germany
    J Biomed Mater Res A 65:319-26. 2003
    ..g., hemodialysis membranes or implants...
  56. pmc Polystyrene nanoparticle trafficking across MDCK-II
    Farnoosh Fazlollahi
    Will Rogers Institute Pulmonary Research Center, University of Southern California, Los Angeles, California 90033, USA
    Nanomedicine 7:588-94. 2011
    ..We conclude that uptake/trafficking of nanoparticles (NPs) into/across epithelia depends both on properties of the NPs and on the specific epithelial cell type...
  57. ncbi Size effects of polystyrene nanoparticles on atopic dermatitislike skin lesions in NC/NGA mice
    R Yanagisawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Int J Immunopathol Pharmacol 23:131-41. 2010
    ..The enhancing effects may be accounted for by T helper 2-biased immune responses. Furthermore, PS nanoparticles can evoke skin inflammation via the overexpression of CC-chemokines even in the absence of allergen in atopic subjects...
  58. ncbi Poly(sodium 4-styrene sulfonate): evaluation of a topical microbicide gel against herpes simplex virus type 2 and Chlamydia trachomatis infections in mice
    N Bourne
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, OH, USA
    Clin Microbiol Infect 9:816-22. 2003
    ..To investigate the in vivo activity of poly(sodium 4-styrene sulfonate) (T-PSS) gel formulations as topical microbicides...
  59. pmc Particles induce apical plasma membrane enlargement in epithelial lung cell line depending on particle surface area dose
    Christina Brandenberger
    Institute of Anatomy, University of Bern, Bern, Switzerland
    Respir Res 10:22. 2009
    ..1 microm) particles may be associated with different effects on the APM. Therefore, we studied particle-induced changes in APM surface area in relation to applied and intracellular particle size, surface and number...
  60. ncbi Measurement of reactive species production by nanoparticles prepared in biologically relevant media
    L Foucaud
    Biomedicine and Sport Science Research Group, School of Life Sciences, Napier University, 10 Colinton Road, Edinburgh EH10 5DT, Scotland, UK
    Toxicol Lett 174:1-9. 2007
    ..In conclusion, 1% BSA and 0.025% DPPC solution was the most efficient for the preparation of a nanoparticle suspension and to measure their oxidative potential...
  61. ncbi Effect of a new injectable male contraceptive on the seminal plasma amino acids studied by proton NMR spectroscopy
    Koel Chaudhury
    Center for Biomedical Engineering, Indian Institute of Technology, New Delhi, India
    Contraception 66:199-204. 2002
    ..In general, the total amino acids concentration in RISUG-injected subjects was found to be higher than in azoospermic subjects, confirming the occurrence of 'partial' obstructive azoospermia in subjects injected with this contraceptive...
  62. ncbi Capillary scale monolithic trap column for desalting and preconcentration of peptides and proteins in one- and two-dimensional separations
    Christian Schley
    Department of Chemistry, Instrumental Analysis and Bioanalysis, Saarland University, 66123 Saarbrucken, Germany
    J Chromatogr A 1136:210-20. 2006
    ....
  63. ncbi Factors associated with adherence to and biofilm formation on polystyrene by Stenotrophomonas maltophilia: the role of cell surface hydrophobicity and motility
    Arianna Pompilio
    Laboratory of Clinical Microbiology, Department of Biomedical Sciences, G D Annunzio University of Chieti Pescara, Chieti, Italy
    FEMS Microbiol Lett 287:41-7. 2008
    ..A highly significant negative correlation was observed between swimming motility and level of hydrophobicity. Hydrophobicity is thus a significant determinant of adhesion and biofilm formation on polystyrene surfaces in S. maltophilia...
  64. pmc Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion
    Miriam Moscoso
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Bacteriol 188:7785-95. 2006
    ..Those results, in turn, may provide insight into strategies to prevent pneumococcal colonization of its human host...
  65. pmc Two-dimensional standing wave total internal reflection fluorescence microscopy: superresolution imaging of single molecular and biological specimens
    Euiheon Chung
    Harvard Massachusetts Institutes of Technology, Division of Health Sciences and Technology, Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biophys J 93:1747-57. 2007
    ..The results confirm the superior resolution of SW-TIRF in addition to the merit of a high signal/background ratio from TIRF microscopy...
  66. ncbi An immunoassay for terbutryn using direct hapten linkage to a glutaraldehyde network on the polystyrene surface of standard microtiter plates
    H Holthues
    Institute of Physical Chemistry, University of Mainz, Germany
    Fresenius J Anal Chem 371:897-902. 2001
    ..The coating-hapten-format presented is proposed as generally applicable, because the glutaraldehyde-modified microtiter plate surface enables stable immobilization of a broad variety of coating haptens...
  67. ncbi Polystyrene nanoparticle trafficking across alveolar epithelium
    Nazanin R Yacobi
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90033, USA
    Nanomedicine 4:139-45. 2008
    ..These data indicate that (1) trafficking of PNP across RAECM is strongly influenced by charge density, size, and temperature, (2) PNP translocate primarily transcellularly, and (3) PNP translocation requires cellular energy...
  68. ncbi Operational variables in high-performance liquid chromatography-electrospray ionization mass spectrometry of peptides and proteins using poly(styrene-divinylbenzene) monoliths
    Wolfgang Walcher
    Institute of Analytical Chemistry and Radiochemistry, Leopold Franzens University, A 6020 Innsbruck, Austria
    J Chromatogr A 1053:107-17. 2004
    ..050% TFA as mobile phase additive turned out to be the best compromise between chromatographic and mass spectrometric performance in the analysis of peptides and proteins by RP-HPLC-ESI-MS using monolithic separation columns...
  69. pmc Cell engineering: nanometric grafting of poly-N-isopropylacrylamide onto polystyrene film by different doses of gamma radiation
    Esmaeil Biazar
    Department of Chemistry, Islamic Azad University, Tonekabon Branch, Mazandaran, Iran
    Int J Nanomedicine 5:549-56. 2010
    ..This characteristic proves that this type of grafted material has potential as a biomaterial for cell sheet engineering...
  70. ncbi Laboratory and field comparisons of pyriproxyfen, polystyrene beads and other larvicidal methods against malaria vectors in Sri Lanka
    A M G M Yapabandara
    Regional Office, Anti Malaria Campaign, Matale, Sri Lanka
    Acta Trop 81:211-23. 2002
    ..However, the reduced required frequency for visiting every pit made the pyriproxyfen method the one of choice. The same low concentration of pyriproxyfen also effectively inhibited emergence of adults from river-bed pools...
  71. ncbi A short-term evaluation of semen and accessory sex gland function in phase III trial subjects receiving intravasal contraceptive RISUG
    S P Chaki
    Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Mehrauli Road, Munirka, New Delhi 110067, India
    Contraception 67:73-8. 2003
    ..Based on the above findings, it is concluded that at least for the present study period, RISUG, a new male contraceptive, is effective as a partially occluding agent in the vas deferens...
  72. ncbi Characterization of some physical and chromatographic properties of monolithic poly(styrene-co-divinylbenzene) columns
    Herbert Oberacher
    Institute of Analytical Chemistry and Radiochemistry, Leopold Franzens University, 6020 Innsbruck, Austria
    J Chromatogr A 1030:201-8. 2004
    ..Batch-to-batch reproducibility proved to be better with granular stationary phases compared to monolithic stationary phase, in which each column bed is the result of a unique column preparation process...
  73. pmc Structure and function of glycosylated tandem repeats from Candida albicans Als adhesins
    Aaron T Frank
    Department of Biology, Brooklyn College, Brooklyn, NY 11210, USA
    Eukaryot Cell 9:405-14. 2010
    ..Together, the modeling techniques and the supporting data lead to an approach that relates structure and function in many kinds of repeat domains in fungal adhesins...
  74. ncbi Endocrine-disrupting effects of styrene oligomers that migrated from polystyrene containers into food
    K Date
    Central Research Institute, Nissin Food Products Co, Ltd, 2247, Noji Cho, Shiga 525 0055, Kusatsu, Japan
    Food Chem Toxicol 40:65-75. 2002
    ..From the above these results, we concluded that SM, SD and ST exhibit no apparent estrogenic, androgenic, anti-androgenic and thyroid activity...
  75. ncbi Transfer of lipophilic markers from PLGA and polystyrene nanoparticles to caco-2 monolayers mimics particle uptake
    Peter Pietzonka
    Institute of Pharmaceutical Sciences, ETH Zurich
    Pharm Res 19:595-601. 2002
    ..Special emphasis was placed on the localization and the quantification of the uptake of fluorescently labeled polystyrene and poly(lactic-co-glycolic acid) (PLGA) nanoparticles...
  76. ncbi An immunoassay for bisphenol A based on direct hapten conjugation to the polystyrene surface of microtiter plates
    Yi Feng
    College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China
    Talanta 80:803-8. 2009
    ..Tap water samples and seawater samples were spiked with a known amount of BPA and measured by ciELISA. The average recoveries were between 70 and 142%. As far as we are aware this is the most sensitive ELISA for BPA yet reported...
  77. ncbi Assessment of styrene oligomers eluted from polystyrene-made food containers for estrogenic effects in in vitro assays
    K Ohno
    Central Research Institute, Nissin Food Products Co, Ltd, 2247, Noji Cho, Kusatsu, 525 0055, Shiga, Japan
    Food Chem Toxicol 39:1233-41. 2001
    ..In all three tests, none of the SM, SDs and STs showed any significant activity. Accordingly, we concluded that these substances have no estrogenic activity...
  78. ncbi Upper gastrointestinal tract injury in patients receiving kayexalate (sodium polystyrene sulfonate) in sorbitol: clinical, endoscopic, and histopathologic findings
    S C Abraham
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Surg Pathol 25:637-44. 2001
    ..Recognition of Kayexalate crystals in histologic sections as a marker for sorbitol-induced mucosal damage may aid in establishing the correct diagnosis for clinically or endoscopically misleading lesions...
  79. ncbi A murine scavenger receptor MARCO recognizes polystyrene nanoparticles
    Sanae Kanno
    Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Toxicol Sci 97:398-406. 2007
    ..These results suggest that macrophages associate with nanoparticles (20 nm) at least in part through MARCO and that MARCO plays a role in clearing nanoparticles which can deposit in the alveolar region...
  80. ncbi An optimized in vitro model of the respiratory tract wall to study particle cell interactions
    Fabian Blank
    Institute of Anatomy, Division of Histology, University of Bern, Bern, Switzerland
    J Aerosol Med 19:392-405. 2006
    ..In this study, we present an in vitro model of the respiratory tract wall consisting of air-exposed lung epithelial cells covered by a liquid lining layer with a surfactant film to study particle-cell interactions...
  81. ncbi Fine particles of widely different composition have an adjuvant effect on the production of allergen-specific antibodies
    B Granum
    Department of Environmental Medicine, National Institute of Public Health, PO Box 4404 Nydalen, N 0403, Oslo, Norway
    Toxicol Lett 118:171-81. 2001
    ..Our results indicate that fine particles of widely different composition may have an adjuvant effect on the production of allergen-specific antibodies...
  82. ncbi Phase II clinical trial of a vas deferens injectable contraceptive for the male
    S K Guha
    Centre for Biomedical Engineering, Indian Institute of Technology and All India Institute of Medical Sciences, New Delhi, India
    Contraception 56:245-50. 1997
    ..The wives were not using any contraceptives. The results reconfirm the safety and show that for a period of at least 1 year, the treatment leads to azoospermia in the male and gives pregnancy protection...
  83. ncbi Biophysical mechanism-mediated time-dependent effect on sperm of human and monkey vas implanted polyelectrolyte contraceptive
    Sujoy K Guha
    School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, India
    Asian J Androl 9:221-7. 2007
    ..To determine the short and long-term morphological effects on sperm as induced by intra-vas alteration of pH and electrical charge...
  84. pmc Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters
    Eric Y H Park
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Biophys J 82:1835-47. 2002
    ..Our results suggest that microvillus extension during transient PSGL-1/P-selectin bonding may enhance the robustness of neutrophil rolling interactions...
  85. ncbi Colonic necrosis and perforation following oral sodium polystyrene sulfonate (Resonium A/Kayexalate in a burn patient
    Eddie S Cheng
    Royal Brisbane Hospital, Herston, QLD 4029, Australia
    Burns 28:189-90. 2002
  86. ncbi Ultrathin poly(N-isopropylacrylamide) grafted layer on polystyrene surfaces for cell adhesion/detachment control
    Yoshikatsu Akiyama
    Institute of Advanced Biomedical Engineering and Science, COE Program for 21st Century, Tokyo Women s Medical University, 8 1 Kawadacho, Shinjuku ku, Tokyo 162 8666, Japan
    Langmuir 20:5506-11. 2004
    ..PIPAAm graft amounts, that is, thickness of the PIPAAm grafted layers, play a crucial role in temperature-induced hydrophilic/hydrophobic property alterations and cell adhesion/detachment behavior...
  87. ncbi Migration of styrene monomer, dimers and trimers from polystyrene to food simulants
    Jin Ok Choi
    Kyungnam University, Division of Food Science and Biotechnology, Korea
    Food Addit Contam 22:693-9. 2005
    ..The diffusion coefficient of the trimers was much higher for heptane contact than for water. The activation energy of the diffusion of trimers for water contact was higher than that for heptane...
  88. ncbi Safety evaluation of long-term vas occlusion with styrene maleic anhydride and its non-invasive reversal on accessory reproductive organs in langurs
    B Manivannan
    Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Asian J Androl 7:195-204. 2005
    ..To evaluate the safety of the long term vas occlusion with styrene maleic anhydride (SMA) and its non-invasive reversal at the level of accessory reproductive glands ARGs in langurs...
  89. ncbi Evaluation of particle translocation across the alveolo-capillary barrier in isolated perfused rabbit lung model
    Abderrahim Nemmar
    K U Leuven, Laboratory of Pneumology Lung Toxicology, Herestraat 49, B 3000 Leuven, Belgium
    Toxicology 208:105-13. 2005
    ..The relevance of these ex vivo findings for the in vivo translocation of inhaled ultrafine particles remains to be established...
  90. ncbi Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates
    Weijun Fang
    Department of Chemistry, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, PR China
    Bioorg Med Chem Lett 19:1903-7. 2009
    ..Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides...
  91. pmc Adhesive surface proteins of Erysipelothrix rhusiopathiae bind to polystyrene, fibronectin, and type I and IV collagens
    Yoshihiro Shimoji
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Bacteriol 185:2739-48. 2003
    ..These results suggest that RspA and RspB participate in initiation of biofilm formation through their binding abilities to abiotic and biotic surfaces...
  92. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2003. A 79-year-old man with coronary artery disease, peripheral vascular disease, end-stage renal disease, and abdominal pain and distention
    Peter B Kelsey
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 349:2147-55. 2003
  93. ncbi The capacity of particles to increase allergic sensitization is predicted by particle number and surface area, not by particle mass
    Unni Cecilie Nygaard
    Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Toxicol Sci 82:515-24. 2004
    ..Consequently, the dose described as total particle surface area or particle number predicts the adjuvant effect of particles better than the currently used particle mass...
  94. ncbi The IgE adjuvant effect of particles: characterisation of the primary cellular response in the draining lymph node
    Unni Cecilie Nygaard
    Department of Environmental Immunology, Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Toxicology 206:181-93. 2005
    ....
  95. ncbi IgE adjuvant effect caused by particles - immediate and delayed effects
    B Granum
    Department of Environmental Medicine, National Institute of Public Health, P O Box 4404 Nydalen, Torshov, N 0403 Oslo, Norway
    Toxicology 156:149-59. 2001
    ..These findings imply that individuals exposed to particulate air pollution at one point of time may develop an increased reaction towards allergens inhaled later that day or even several days after the particle exposure...
  96. ncbi Heparin-carrying polystyrene (HCPS)-bound collagen substratum to immobilize heparin-binding growth factors and to enhance cellular growth
    M Ishihara
    National Defense Medical College, Research Institute, Division of Biomedical Engineering, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
    J Biomed Mater Res 56:536-44. 2001
    ..These results indicate that HCPS-bound collagen substrata with various bioactive heparin-binding molecules may provide novel biomaterials controlling cellular activities such as growth and differentiation...
  97. ncbi The adjuvant effect of particles-importance of genetic background and pre-sensitisation
    B Granum
    Department of Environmental Medicine, National Institute of Public Health, Ulleval University Hospital, Oslo, Norway
    Int Arch Allergy Immunol 122:167-73. 2000
    ..The purpose of this study was to explore the importance of genetic background concerning the adjuvant effect of PSP in different strains of mice...
  98. ncbi Phagocytic activity of alveolar macrophages toward polystyrene latex microspheres and PLGA microspheres loaded with anti-tuberculosis agent
    Taizo Hasegawa
    Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Colloids Surf B Biointerfaces 60:221-8. 2007
    ..From the changes in N and n values with MS/Mphi, the phagocytosis of RFP-PLGA MS was likely to enhance the phagocytic activity of Mphi cells, but this effect did not seem to be significant for PSL MS...
  99. ncbi Synthesis, characterization and catalytic application of silver nanoshell coated functionalized polystyrene beads
    Subhra Jana
    Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India
    J Nanosci Nanotechnol 7:2151-6. 2007
    ..The synthesis of the solid phase catalyst particles, their application and detailed kinetic aspects of the reduction of 4-nitrophenol have been reported...
  100. ncbi Inhibiting surface crystallization of amorphous indomethacin by nanocoating
    Tian Wu
    School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, Wisconsin 53705 2222, USA
    Langmuir 23:5148-53. 2007
    ..This technique may be used to stabilize amorphous drugs prone to surface crystallization, with the aqueous coating process especially suitable for drugs of low aqueous solubility...
  101. ncbi Defect-free nanoporous thin films from ABC triblock copolymers
    Joona Bang
    Department of Chemical and Biological Engineering, Korea University, Seoul 136 713, Republic of Korea
    J Am Chem Soc 128:7622-9. 2006
    ....

Research Grants48

  1. Biofilm growth and detachment of an oral pathogen
    Jeffrey Kaplan; Fiscal Year: 2007
    ..abstract_text> ..
  2. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  3. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
    ..These projected investigations should generate substantial new knowledge about complex synthesis as well as providing additional insight into some of the bioactivity exhibited by the subject natural products. ..
  4. Modeling of Aerosol Transport in Alveolated Airways
    Chantal Darquenne; Fiscal Year: 2009
    ..The results of this study will provide a link to the mechanisms by which even seemingly modest PM exposure can cause or exacerbate lung disease and will also help to better design spatial targeting of inhaled drugs. ..
  5. Development of MIDI-Ray Implant for Glaucoma
    Leonard Pinchuk; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. UV RESONANCE RAMAN STUDIES OF PROTEIN STRUCTURE
    Sanford Asher; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. A microscale sorting cytometer for cell-based screens
    Joel Voldman; Fiscal Year: 2008
    ..abstract_text> ..
  8. PROTECTION OF GENITAL MUCOSA AND GANGLIA AGAINST HSV-2
    Gregg N Milligan; Fiscal Year: 2010
    ..The results of these studies should be important for the rational development of HSV vaccines as well as understanding the cellular interactions and specific molecular mechanisms required for resolution of HSV lesions. ..
  9. Nanoarray-Type Detection of Oct3/4 and Cdx2 using AuNPs and E-beam Patterns
    Jeong Yeol Yoon; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. Integrin-specific implant surfaces for bone repair
    Andres Garcia; Fiscal Year: 2008
    ..Collectively, these studies will validate this biomolecular surface engineering approach for developing biologically active implants for enhanced bone repair. ..
  11. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2007
    ....
  12. Anti-larval measures for malaria control in The Gambia
    Steven Lindsay; Fiscal Year: 2007
    ..The results from this study will make a major contribution to quantifying the importance of the use of Bs and Bti in the fight against malaria. ..
  13. Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)
    W Saltzman; Fiscal Year: 2008
    ..abstract_text> ..
  14. Interdisciplinary Pre-doctoral Training Program in Neuroengineering(RMI)
    W Saltzman; Fiscal Year: 2008
    ..abstract_text> ..
  15. Microchip to Detect Influenza Infection and Type in Nasopharyngeal Swabs
    Catherine M Klapperich; Fiscal Year: 2010
    ....
  16. Towards Mega-Throughput, Label-free Genomics and Proteomics: Revolutionizing Micr
    Aydogan Ozcan; Fiscal Year: 2009
    ....
  17. Immunization to Reduce Genital and Neonatal Herpes
    Nigel Bourne; Fiscal Year: 2009
    ..These study designs may become standard for preclinical evaluation of HSV vaccines. ..
  18. Microscale control of stem cell signaling using cell patterning and perfusion
    Joel Voldman; Fiscal Year: 2010
    ..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
  19. MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
    W Saltzman; Fiscal Year: 2008
    ..abstract_text> ..
  20. SCREENING PLATELETS INTERACTIONS WITH SURFACE GRADIENTS
    Vladimir Hlady; Fiscal Year: 2009
    ....
  21. NOVEL CLINICAL CHEMISTRY SENSING MOTIF
    Sanford Asher; Fiscal Year: 2009
    ..The analyte sensing will be monitored by using a simple Palm Pilot-type instrument that utilizes a color CCD camera. The results could be immediately displayed, and easily recorded if the device is operated as a patient biographer. ..
  22. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  23. Interaction between host cells and multicomponent material matrix
    WEIYUAN KAO; Fiscal Year: 2009
    ..e., human blood-derived macrophages, dermal fibroblasts, and keratinocytes) using monoculture and binary cell culture systems. (3) To ascertain IPN efficacy in vivo in modulating the host reaction and healing. ..
  24. Multi-Parametric Characterization of Human Islets: Predictor of Islet Quality, Po
    Luis Fernandez; Fiscal Year: 2008
    ..abstract_text> ..
  25. Vaccine-elicited genital and neuronal T cell responses
    Gregg Milligan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. Microfluidic/controlled systems on brain microprobes
    W Saltzman; Fiscal Year: 2007
    ..abstract_text> ..
  27. Non-Enzymatic Cell Lysis/Protein Digestion Proteomics
    Franco Basile; Fiscal Year: 2005
    ..Advantages anticipated from these studies include the ability to perform high throughput sample preparation for proteomic measurements and its direct effect on the rapid diagnosis of microbial related diseases. ..
  28. Development of an Orbital Tissue Expander for Babies
    Leonard Pinchuk; Fiscal Year: 2003
    ..Phase II will be geared toward long-term in vivo testing of the device, stepping up production of the orbital expander for commercialization, regulatory submissions and clinical testing. ..
  29. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2003
    ..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
  30. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2003
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  31. UV RESONANCE RAMAN STUDIES OF PROTEIN STRUCTURE
    Sanford Asher; Fiscal Year: 2002
    ..We will continue to advance the enabling UV Raman instrumentation with the objective of increasing sensitivity, selectivity and information content. ..
  32. CONSTRUCTING NEUROTROPHIN FIELDS IN THE BRAIN
    W Saltzman; Fiscal Year: 2002
    ..abstract_text> ..
  33. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2001
    ..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
  34. NOVEL CLINICAL CHEMISTRY SENSING MOTIF
    Sanford Asher; Fiscal Year: 2001
    ..This motif is highly flexible and can be modified to sense a broad variety and concentration of biologically relevant analytes. ..
  35. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2001
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  36. MOLECULAR AND CELLULAR TRANSPORT IN MUCUS
    W Saltzman; Fiscal Year: 2001
    ..Finally, these polymeric systems will be used to test the efficacy of delivery for sustained protection against unwanted pregnancy (immunocontraception). ..
  37. Catalytic and Stereoselective C-C Bond Forming Reaction
    AMIR HOVEYDA; Fiscal Year: 2004
    ..The utility of the new methods will be demonstrated by synthesis of anticancer LY300502, antispastic baclofen, anti-fungal aflatoxin B2, antidepressant gemfexine and anti-leukemic helianane. ..
  38. Morpholino Antisense Drugs for Hepatitis C Virus
    Nigel Bourne; Fiscal Year: 2004
    ..The proposed research, if successful, would lead to a application for Phase II funding to bring the use of PMOs into the HCV drug market and provide a well-tolerated, inexpensive alternative to current HCV treatments. ..
  39. Continuous cell screening using iso-dielectric separation
    Joel Voldman; Fiscal Year: 2006
    ..This has the potential to both increase the class of biomolecules available as well as more efficiently find & produce them. ..
  40. Micro-and Nano-engineering of Biomineralized Materials
    W Saltzman; Fiscal Year: 2006
    ..Since precisely designed synthetic materials will be produced and characterized to meet the study objectives, this project will also lead to new approaches for engineering of dental and orthopedic tissue. ..
  41. Genetic.Engin.Cells/Scaffolds for Bone Tissue Engineeri.
    Andres Garcia; Fiscal Year: 2006
    ..abstract_text> ..
  42. Donation After Cardiac Death for Isolated Pancreatic Is*
    Luis Fernandez; Fiscal Year: 2006
    ..In addition, the development of rapid, accurate, and predictive tests of islet viability and function post isolation will contribute to significant improvements in post transplant success. ..
  43. Development of (Non) Invasive Real-Time Glucose Sensors
    Sanford Asher; Fiscal Year: 2005
    ..abstract_text> ..
  44. A Novel Polymer Trileaflet Heart Valve
    Leonard Pinchuk; Fiscal Year: 2005
    ..The primary outcome of Phase II will be the data required for an application to the FDA to obtain a Feasibility Investigational Device Exemption (IDE). Clinical trials will follow this approval. ..
  45. Multiplex system for stem cell culture and in situ assay
    Joel Voldman; Fiscal Year: 2004
    ..abstract_text> ..
  46. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..The proposed research is expected to help transform this ideal into a reality. ..
  47. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
  48. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..