polypropylenes

Summary

Summary: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.

Top Publications

  1. ncbi Relationship between tissue ingrowth and mesh contraction
    Rodrigo Gonzalez
    Department of Surgery, Emory Endosurgery Unit and Hernia Institute, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, Georgia 30322, USA
    World J Surg 29:1038-43. 2005
  2. ncbi The influence of differing pore sizes on the biocompatibility of two polypropylene meshes in the repair of abdominal defects. Experimental study in dogs
    F H Greca
    Department of Experimental Surgery, Pontifical Catholic University of Parana, Brazil
    Hernia 5:59-64. 2001
  3. ncbi Individual inflammatory response of human blood monocytes to mesh biomaterials
    A Schachtrupp
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Br J Surg 90:114-20. 2003
  4. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
  5. ncbi Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibilty
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Hernia 9:115-9. 2005
  6. ncbi Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin E acetate and F127 polymer on liquid crystal nanostructure
    Yao Da Dong
    Department of Pharmaceutics, Victoria College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
    Langmuir 22:9512-8. 2006
  7. pmc Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia
    David Shin
    Division of Male Reproductive Medicine and Surgery, Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    Ann Surg 241:553-8. 2005
  8. ncbi Transscleral fixation of foldable intraocular lenses
    Suleyman Kaynak
    Department of Ophthalmology, Dokuz Eylul University School of Medicine, 1388 sok No 16 A, Alsancak, Izmir, Turkey
    J Cataract Refract Surg 30:854-7. 2004
  9. ncbi Incisional abdominal hernia: the open mesh repair
    V Schumpelick
    Department of Surgery, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:1-5. 2004
  10. ncbi Fabrication and characterization of poly(propylene fumarate) scaffolds with controlled pore structures using 3-dimensional printing and injection molding
    Kee Won Lee
    Tissue Engineering and Polymeric Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Tissue Eng 12:2801-11. 2006

Research Grants

  1. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2007
  2. Complex Ventral Hernia Repair
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
  3. Engineered Biologics for Repair of Abdominal Wall Musculofascia
    Anshu B Mathur; Fiscal Year: 2013
  4. Absorbable Triphasic Hernial Meshes
    Shalaby W Shalaby; Fiscal Year: 2010
  5. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2010
  6. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2013
  7. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2012
  8. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2011
  9. Advanced Energy Storage Film Capacitors for Automated External Defibrillators
    Shihai Zhang; Fiscal Year: 2011
  10. Surface Enhanced Biocompatible Blood Oxygenators
    Daniel Campos; Fiscal Year: 2010

Detail Information

Publications274 found, 100 shown here

  1. ncbi Relationship between tissue ingrowth and mesh contraction
    Rodrigo Gonzalez
    Department of Surgery, Emory Endosurgery Unit and Hernia Institute, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, Georgia 30322, USA
    World J Surg 29:1038-43. 2005
    ..PE resulted in less contraction than polypropylene. A strong integration of the mesh into the tissue helps prevent this phenomenon, which is evidenced by a significant correlation between tissue ingrowth force and mesh size...
  2. ncbi The influence of differing pore sizes on the biocompatibility of two polypropylene meshes in the repair of abdominal defects. Experimental study in dogs
    F H Greca
    Department of Experimental Surgery, Pontifical Catholic University of Parana, Brazil
    Hernia 5:59-64. 2001
    ....
  3. ncbi Individual inflammatory response of human blood monocytes to mesh biomaterials
    A Schachtrupp
    Department of Surgery, Rhenish Westphalian Technical University, Aachen, Germany
    Br J Surg 90:114-20. 2003
    ..As monocytes take a key position in the inflammatory foreign body reaction, their specific release of cytokines was investigated in vitro after incubation with alloplastic materials...
  4. pmc Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia
    Jacobus W A Burger
    Department of General Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Surg 240:578-83; discussion 583-5. 2004
    ..The objective of this study was to determine the best treatment of incisional hernia, taking into account recurrence, complications, discomfort, cosmetic result, and patient satisfaction...
  5. ncbi Titanium coating of a polypropylene mesh for hernia repair: effect on biocompatibilty
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
    Hernia 9:115-9. 2005
    ..No significant improvement of biocompatibility was found when analyzing the effect of titanium coating compared to the pure polypropylene mesh structure...
  6. ncbi Bulk and dispersed aqueous phase behavior of phytantriol: effect of vitamin E acetate and F127 polymer on liquid crystal nanostructure
    Yao Da Dong
    Department of Pharmaceutics, Victoria College of Pharmacy, Monash University, Parkville, Victoria 3052, Australia
    Langmuir 22:9512-8. 2006
    ..Taken together, these results indicate that phytantriol may not only provide an alternative lipid for preparation of liquid crystalline systems in excess water but may also provide access to properties not available when using GMO...
  7. pmc Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia
    David Shin
    Division of Male Reproductive Medicine and Surgery, Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA
    Ann Surg 241:553-8. 2005
    ..To report a multiinstitutional experience of men presenting with infertility secondary to inguinal hernia repair using polypropylene mesh...
  8. ncbi Transscleral fixation of foldable intraocular lenses
    Suleyman Kaynak
    Department of Ophthalmology, Dokuz Eylul University School of Medicine, 1388 sok No 16 A, Alsancak, Izmir, Turkey
    J Cataract Refract Surg 30:854-7. 2004
    ..To report the results of transscleral implantation of foldable intraocular lenses (IOLs)...
  9. ncbi Incisional abdominal hernia: the open mesh repair
    V Schumpelick
    Department of Surgery, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:1-5. 2004
    ..Mesh techniques are the methods of choice for the repair of incisional hernias since these are due to the formation of unstable scar tissue...
  10. ncbi Fabrication and characterization of poly(propylene fumarate) scaffolds with controlled pore structures using 3-dimensional printing and injection molding
    Kee Won Lee
    Tissue Engineering and Polymeric Biomaterials Laboratory, Departments of Orthopedic Surgery and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Tissue Eng 12:2801-11. 2006
    ..These results show that 3D printing and injection molding technique can be applied to crosslinkable polymers to fabricate 3D porous scaffolds with controlled pore structures, porosity, and permeability using their CAD models...
  11. ncbi Three-year follow-up of modified Lichtenstein inguinal hernioplasty using lightweight poliglecaprone/polypropylene mesh
    M Smietanski
    Department of General and Endocrine Surgery and Transplantation, Medical University of Gdansk, ul Debinki 7, 80 211, Gdansk, Poland
    Hernia 13:239-42. 2009
    ....
  12. ncbi Prevention of adhesion formations following repair of abdominal wall defects with prosthetic materials (an experimental study)
    Orhan Alimoglu
    First Department of Surgery, Vakif Gureba Training Hospital, Istanbul, Turkey
    Hepatogastroenterology 50:725-8. 2003
    ..The aim of this study was to compare different modalities in terms of adhesion prevention in a rat model of abdominal wall defect repaired with prosthetic materials...
  13. ncbi Low-weight polypropylene mesh for anterior vaginal wall prolapse: a randomized controlled trial
    Reijo Hiltunen
    Department of Obstetrics and Gynecology at the Central Hospital of South Ostrobothnia, Seinajoki, Finland
    Obstet Gynecol 110:455-62. 2007
    ..To compare anterior colporrhaphy with and without a tailored mesh...
  14. ncbi Randomized clinical trial of lightweight composite mesh for Lichtenstein inguinal hernia repair
    S Post
    Department of Surgery, Mannheim Medical Centre, University of Heidelberg, Heidelberg, Germany
    Br J Surg 91:44-8. 2004
    ..This study evaluated whether patients noticed any difference between lightweight and standard polypropylene mesh for the repair of inguinal hernia...
  15. ncbi The phenomenon of infection with abdominal wall reconstruction
    Anton F Engelsman
    Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biomaterials 28:2314-27. 2007
    ..It is shown that there are major physico-chemical differences between available meshes, which, in combination with the location of the mesh, the surgical technique applied and hernia type involved influence the infection potential...
  16. ncbi Comparing the behavior of different polypropylene meshes (heavy and lightweight) in an experimental model of ventral hernia repair
    J M Bellon
    Department of Surgery, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER BBN, Alcala University, Alcala de Henares, Madrid, Spain
    J Biomed Mater Res B Appl Biomater 89:448-55. 2009
    ..Compared with HW, LW prostheses have the benefit that less foreign material was implanted, preserving the elasticity of the recipient host tissue...
  17. ncbi Physicomechanical evaluation of polypropylene, polyester, and polytetrafluoroethylene meshes for inguinal hernia repair
    Corey R Deeken
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Coll Surg 212:68-79. 2011
    ..The objectives of this study were to propose standard techniques, perform physicomechanical testing, and classify materials commonly used for inguinal hernia repair...
  18. ncbi Anisotropic evaluation of synthetic surgical meshes
    E R Saberski
    University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Hernia 15:47-52. 2011
    ..Haphazard orientation of anisotropic mesh material can contribute to inconsistent surgical outcomes. We aimed to characterize and compare anisotropic properties of commonly used synthetic meshes...
  19. ncbi Early results of a randomized multicenter trial comparing Prolene and VyproII mesh in bilateral endoscopic extraperitoneal hernioplasty (TEP)
    S Bringman
    Center for Surgical Sciences, Karolinska Institutet, Sodertalje Hospital, SE 15286, Sodertalje, Sweden
    Surg Endosc 19:536-40. 2005
    ..The purpose of this study was to compare the use of a lightweight mesh vs a standard hernia mesh in bilateral endoscopic hernioplasty...
  20. ncbi Comparison of recurrence with lightweight composite polypropylene mesh and heavyweight mesh in laparoscopic totally extraperitoneal inguinal hernia repair: an audit of 1,232 repairs
    D Akolekar
    Department of Surgery, Royal Infirmary Edinburgh, 51, Little France Crescent, Edinburgh, EH16 4SA, UK
    Hernia 12:39-43. 2008
    ..The aim of this study was to compare the outcome following the use of a new lightweight vs a standard heavyweight mesh during TEP hernia repair...
  21. ncbi One year results of a randomised controlled multi-centre study comparing Prolene and Vypro II-mesh in Lichtenstein hernioplasty
    S Bringman
    Center for Surgical Sciences, Karolinska Institutet, Department of Surgery, Sodertalje Hospital, 15286 Södertälje, Sweden
    Hernia 9:223-7. 2005
    ..One Vypro II-patient was re-operated due to neuralgia. There was no difference in the SF-36 scores. The results of Lichtenstein's operation with either Prolene or Vypro II do not seem to differ significantly...
  22. ncbi Resection of sternal tumors and reconstruction of the thorax: a review of 15 patients
    Shuji Haraguchi
    Department of Surgery, Nippon Medical School Second Hospital, 1 396 Kosugi cho, Nakahara ku, Kawasaki, Kanagawa, 211 8533, Japan
    Surg Today 36:225-9. 2006
    ..We report our experience of resecting sternal tumors, followed by reconstruction of the skeletal and soft-tissue defects, and discuss the usefulness of sandwiched Marlex and stainless-steel mesh...
  23. ncbi Lightweight mesh improves functional outcome in laparoscopic totally extra-peritoneal inguinal hernia repair
    L R Khan
    Department of Clinical and Surgical Sciences Surgery, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK
    Hernia 14:39-45. 2010
    ..The aim of this prospective study was to compare the outcome after laparoscopic totally extra-peritoneal (TEP) inguinal repair using new lightweight or traditional heavyweight mesh performed in a single specialist centre...
  24. ncbi Interactions between U-937 human macrophages and poly(propyleneimine) dendrimers
    Jung Hua Steven Kuo
    Graduate Institute of Pharmaceutical Science, Chia Nan University of Pharmacy and Science, Sec 1, Jen Te, Tainan, Taiwan
    J Control Release 120:51-9. 2007
    ..Our findings provide a novel insight into the cytotoxic effects at the molecular level that dendrimers cause in macrophages...
  25. ncbi Broad based tension-free synthetic sling for stress urinary incontinence: 5-year outcome
    Darshan K Shah
    Department of Urology, Long Island Jewish Medical Center, 270 05 76th Avenue, New Hyde Park, NY 11040, USA
    J Urol 170:849-51. 2003
    ..The use of nonabsorbable synthetic material has been questioned due to reports of erosion and infection. We present the 5-year followup outcome of stress urinary incontinence (SUI) treated using polypropylene mesh as a pubovaginal sling...
  26. ncbi Tissue reactions of the rabbit urinary bladder to cadaveric human fascia lata and polypropylene surgical mesh
    Danny M Rabah
    Department of Urology, McGill University Health Center, Montreal, Quebec, Canada
    Can J Urol 11:2344-9. 2004
    ..To evaluate and compare histological tissue reactions of the urinary bladder to human cadaveric fascia lata (CFX) slings and synthetic mesh...
  27. ncbi Macroporous condensed poly(tetrafluoroethylene). I. In vivo inflammatory response and healing characteristics
    Gabriela Voskerician
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Biomed Mater Res A 76:234-42. 2006
    ....
  28. ncbi The argument for lightweight polypropylene mesh in hernia repair
    William S Cobb
    Carolinas Laparoscopic and Advanced Surgery Program, Carolinas Medical Center, Charlotte, NC 28203, USA
    Surg Innov 12:63-9. 2005
    ..A review of the laboratory data and short-term clinical follow-up is reviewed to provide a strong basis or argument for the use of ''light weight'' prosthetics in hernia surgery...
  29. ncbi Prevention of adhesions to polypropylene mesh
    Isaac Felemovicius
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    J Am Coll Surg 198:543-8. 2004
    ..Adhesions may lead later to difficult reoperation, intestinal obstruction, or enteric fistula...
  30. ncbi In vivo studies comparing the biocompatibility of various polypropylene meshes and their handling properties during endoscopic total extraperitoneal (TEP) patchplasty: an experimental study in pigs
    H Scheidbach
    Department of Surgery, Otto von Guericke University Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Surg Endosc 18:211-20. 2004
    ..We tested several recently modified PP meshes to evaluate them in terms of their biocompatibility and handling characteristics during minimally invasive procedures...
  31. ncbi Prevention of adhesion formation to polypropylene mesh by collagen coating: a randomized controlled study in a rat model of ventral hernia repair
    M van't Riet
    Department of General Surgery, Erasmus University Medical Centre Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Surg Endosc 18:681-5. 2004
    ..The aim of this study was to assess whether the addition of a collagen coating on the visceral side of a polypropylene mesh can prevent adhesion formation to the mesh...
  32. ncbi Repair of large midline incisional hernias with polypropylene mesh: comparison of three operative techniques
    T S de Vries Reilingh
    Department of Surgery, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Hernia 8:56-9. 2004
    ..22). Repair of large midline incisional hernias with the use of a polypropylene mesh carries a high risk of complications and has a high reherniation rate. The underlay technique seems to be the better technique...
  33. ncbi Endoscopic removal of intravesical polypropylene sling with the holmium laser
    Marc Hodroff
    Center for Continence Care at Metropolitan Urologic Specialists, St Paul, Minnesota, USA
    J Urol 172:1361-2. 2004
  34. pmc Prevention of adhesion to prosthetic mesh: comparison of different barriers using an incisional hernia model
    Martijne van 't Riet
    Department of General Surgery, Erasmus University Medical Centre, Rotterdam Dijkzigt, The Netherlands
    Ann Surg 237:123-8. 2003
    ..To assess whether use of antiadhesive liquids or coatings could prevent adhesion formation to prosthetic mesh...
  35. ncbi Do multifilament alloplastic meshes increase the infection rate? Analysis of the polymeric surface, the bacteria adherence, and the in vivo consequences in a rat model
    U Klinge
    Department of Surgery Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Biomed Mater Res 63:765-71. 2002
    ..In vivo, the adherence of bacteria to the implant material depends on the surface area, which favors the use of monofilament materials...
  36. ncbi Health-related quality of life in patients treated for incisional hernia with an onlay technique
    M M Poelman
    Department of Surgery, Medisch Centrum Alkmaar, Wilhelminalaan 12, 1815 JD, Alkmaar, The Netherlands
    Hernia 14:237-42. 2010
    ..The aim of this study was to investigate the long-term health-related quality of life (HRQL) of patients who were treated for incisional hernias using an onlay technique...
  37. ncbi Evaluation of peritoneal adhesions formation and tissue response to polypropylene - poli (2-hydroxyethyl methacrylate)-(polyHEMA) implant on rats' abdominal wall
    Neusa Margarida Paulo
    Veterinary Surgery, Department of Veterinary Medicin, Universidade Federal de Goias, Goiania, GO, Brazil
    Acta Cir Bras 25:337-41. 2010
    ....
  38. ncbi [Pathology of traditional surgical nets for hernia repair after long-term implantation in humans]
    B Klosterhalfen
    Institut für Pathologie Direktor Prof Dr C Mittermayer der RWTH Aachen
    Chirurg 71:43-51. 2000
    ..This reaction is mainly influenced by the selected mesh modification. The consequences of the arising "chronic wound" are discussed in detail, in particular with regard to possible malignant transformation...
  39. ncbi Biomechanical analysis of polypropylene prosthetic implants for hernia repair: an experimental study
    Fabrice Sergent
    Rouen University, UPRES EA GRHV, France
    Am J Surg 200:406-12. 2010
    ..Although polypropylene (PP) is the most common biomaterial used for ventral and inguinal hernia repairs, its mechanical properties remain obscure...
  40. ncbi Effects of resterilization on mechanical properties of polypropylene meshes
    Kemal Serbetci
    Department of Biomedical Engineering, Baskent University, Baglica Kampusu, Eskisehir Yolu 20 Km, 06530, Ankara, Turkey
    Am J Surg 194:375-9. 2007
    ..The purpose of this study was to determine the effects of ethylene oxide and autoclave resterilization on the mechanical properties of polypropylene meshes...
  41. ncbi Functional and morphologic properties of a modified mesh for inguinal hernia repair
    Karsten Junge
    Department of Surgery, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    World J Surg 26:1472-80. 2002
    ..The present study thus confirms the benefits of material-reduced mesh modifications. The new low-weight mesh (Vypro II) could be advantageous in inguinal hernia repair...
  42. ncbi Persistent extracellular matrix remodelling at the interface to polymers used for hernia repair
    K Junge
    Department of Surgery, German Centre of Excellence for Biomaterial and Implant Pathology, Technical University of Aachen, Aachen, Germany
    Eur Surg Res 35:497-504. 2003
    ..951, p = 0.049), there was no relation to the expression of collagenases (MMP-1/MMP-13) with regard to the amount of inflammatory and connective tissue formation despite partly significant differences between implanted polymers...
  43. ncbi Prolapse repair by vaginal route using a new protected low-weight polypropylene mesh: 1-year functional and anatomical outcome in a prospective multicentre study
    Renaud de Tayrac
    Department of Obstetrics and Gynaecology, Caremeau University Hospital, place du Professeur Robert Debré, 30029, Nimes, Cedex 9, France
    Int Urogynecol J Pelvic Floor Dysfunct 18:251-6. 2007
    ..0001). The use of low-weight polypropylene mesh coated with a hydrophilic absorbable film for vaginal repair of genital prolapse seems to decrease local morbidity while maintaining low recurrence rates...
  44. ncbi Functional impairment and complaints following incisional hernia repair with different polypropylene meshes
    G Welty
    Department of Surgery, Technical University of Aachen, Germany
    Hernia 5:142-7. 2001
    ..Three-dimensional stereographic examinations were well in accordance with our clinical findings. Our data support the hypothesis that the use of low-weight large-pore meshes is advantageous for abdominal wall function...
  45. ncbi Randomized clinical trial comparing a polypropylene with a poliglecaprone and polypropylene composite mesh for inguinal hernioplasty
    M Smietanski
    Department of General and Endocrine Surgery and Transplantation, Medical University of Gdansk, 7 Debinki Street, 80 211 Gdansk, Poland
    Br J Surg 95:1462-8. 2008
    ..The aim was to assess whether a partially absorbable monofilament mesh could influence postoperative pain and time to return to normal activity after Lichtenstein hernioplasty...
  46. ncbi Complications of tension-free vaginal tape surgery: a multi-institutional review
    Robert Abouassaly
    Department of Urology, McGill University, Montreal, Quebec, Canada
    BJU Int 94:110-3. 2004
    ....
  47. ncbi Primary incisional hernia repair with or without polypropylene mesh: a report on 384 patients with 5-year follow-up
    Stefan Sauerland
    Klinik für Allgemein und Visceralchirurgie, Marienhospital Stuttgart, Böheimstrasse 37, 70199, Stuttgart, Germany
    Langenbecks Arch Surg 390:408-12. 2005
    ..We investigated the relative effectiveness of mesh and suture repair in a large homogeneous cohort of patients with primary incisional hernia...
  48. ncbi Prosthetic implants for hernia repair
    V Schumpelick
    Department of Surgery, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Br J Surg 90:1457-8. 2003
  49. ncbi Randomized clinical trial comparing lightweight composite mesh with polyester or polypropylene mesh for incisional hernia repair
    J Conze
    Department of Surgery, University Clinic Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Br J Surg 92:1488-93. 2005
    ..A new generation of mesh has been developed with reduced polypropylene mass and increased pore size. The aim of this study was to compare standard mesh with new lightweight mesh in patients undergoing incisional hernia repair...
  50. ncbi Heavy-weight versus low-weight polypropylene meshes for open sublay mesh repair of incisional hernia
    S Schmidbauer
    Department of Surgery Innenstadt, Klinikum der Universitat Munchen, Germany
    Eur J Med Res 10:247-53. 2005
    ..The objective of this study was to determine early complications and the long-term course of patients who underwent open sublay hernia repair using heavy-weight versus low-weight PP meshes...
  51. ncbi Decreased collagen type I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses
    Karsten Junge
    Department of Surgery, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Langenbecks Arch Surg 389:17-22. 2004
    ..Whereas alloplastic prostheses are nowadays routinely used, the quantity and quality of collagen formation after repair in humans has not been analysed in a large cohort...
  52. ncbi Influence of titanium coating on the biocompatibility of a heavyweight polypropylene mesh. An animal experimental model
    H Scheidbach
    Department of Surgery, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Eur Surg Res 36:313-7. 2004
    ....
  53. ncbi Prosthetic closure of the esophageal hiatus in large hiatal hernia repair and laparoscopic antireflux surgery
    F A Granderath
    Department of General, Visceral and Transplant Surgery, University Hospital of Tuebingen, Tuebingen, Germany
    Surg Endosc 20:367-79. 2006
    ..The aim of this article was to review available studies regarding the evolution, different techniques, results, and future perspectives concerning the use of prosthetic materials for closure of the esophageal hiatus...
  54. ncbi Influence of polyglecaprone 25 (Monocryl) supplementation on the biocompatibility of a polypropylene mesh for hernia repair
    K Junge
    Department of Surgery, Technical University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Hernia 9:212-7. 2005
    ..This study was designed to evaluate the influence of this additional supplementation on the biocompatibility in a rodent animal model...
  55. ncbi Randomized clinical trial of suture repair, polypropylene mesh or autodermal hernioplasty for incisional hernia
    M Korenkov
    Surgical Clinic and Biochemical and Experimental Division, Second Department of Surgery, University of Cologne, Cologne, Germany
    Br J Surg 89:50-6. 2002
    ..Since conventional suture repair for incisional hernia is associated with high recurrence rates, alloplastic and autoplastic prosthetic techniques have been suggested...
  56. ncbi [Twenty-five years of experience in incisional hernia surgery. A comparative retrospective study of 432 incisional hernia repairs]
    C Langer
    Klinik und Poliklinik für Allgemeinchirurgie, Georg August Universitat, Gottingen
    Chirurg 74:638-45. 2003
    ..The relevance of different factors such as surgical technique, mesh material, and patient-related parameters concerning the outcome following mesh repair is still under debate...
  57. ncbi The influence of porosity on the integration histology of two polypropylene meshes for the treatment of abdominal wall defects in dogs
    F H Greca
    Experimental Surgery Department, Pontifical Catholic University of Parana, Parana, Brazil
    Hernia 12:45-9. 2008
    ..We conclude that Mpathy mesh gives a surgical repair that is at least as strong as that provided by Prolene, along with a higher concentration of mature collagen and less fibrosis (P=0.07), in this canine histology model...
  58. ncbi Improving outcomes in hernia repair by the use of light meshes--a comparison of different implant constructions based on a critical appraisal of the literature
    Dirk Weyhe
    Department of Surgery, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
    World J Surg 31:234-44. 2007
    ..This overview of the literature aimed to establish whether absolute material reduction (g per implanted mesh), use of absorbable components, and coating by inert materials are evidence-based ways to improve biocompatibility of meshes...
  59. ncbi A lightweight, partially absorbable mesh (Ultrapro) for endoscopic hernia repair: experimental biocompatibility results obtained with a porcine model
    C Schug-Pass
    Department of Surgery and Center for Minimally Invasive Surgery, Hanover Hospital, Roesebeckstrasse 15 Siloah, 30449, Hanover, Germany
    Surg Endosc 22:1100-6. 2008
    ..Mesh "shrinkage" is a function of the mesh's biocompatibility, that is, the properties of the mesh. Large-pore, lightweight polypropylene meshes possess the best biocompatibility, and the newly developed meshes meet these requirements...
  60. pmc A randomised, multi-centre, prospective, double blind pilot-study to evaluate safety and efficacy of the non-absorbable Optilene Mesh Elastic versus the partly absorbable Ultrapro Mesh for incisional hernia repair
    Christoph Seiler
    University of Heidelberg, Department of Surgery, Germany
    BMC Surg 10:21. 2010
    ..The aim of this study is to evaluate, if a non-absorbable mesh (Optilene Mesh Elastic) will result in better health outcomes compared to a partly absorbable mesh (Ultrapro Mesh)...
  61. ncbi [Standardized sublay technique in polypropylene mesh repair of incisional hernia. A prospective clinical study]
    C Langer
    Klinik und Poliklinik für Allgemeinchirurgie, Georg August Universitat Gottingen
    Chirurg 72:953-7. 2001
    ..Special complications such as scar plates with restriction of the mobility of the abdominal wall, pain and fistula formation are described...
  62. ncbi Randomized clinical trial assessing impact of a lightweight or heavyweight mesh on chronic pain after inguinal hernia repair
    P J O'Dwyer
    Western Infirmary, Glasgow, Sunderland, UK
    Br J Surg 92:166-70. 2005
    ..The aim of this randomized study was to compare pain of any severity at 12 months after inguinal hernia repair with a partially absorbable lightweight mesh (LW group) or with a non-absorbable heavyweight mesh (HW group)...
  63. pmc Long term outcome and quality of life after open incisional hernia repair--light versus heavy weight meshes
    Roland Ladurner
    Department of Surgery Innenstadt, Ludwig Maximilian University of Munich, Nussbaumstrasse 20, Munich, Germany
    BMC Surg 11:25. 2011
    ..The aim of this retrospective non randomized study was to compare the quality of life in the long term follow up (> 72 month) after incisional hernia repair with "light weight"(LW) and "heavy weight"(HW) PP meshes...
  64. ncbi Influence of polyglactin-coating on functional and morphological parameters of polypropylene-mesh modifications for abdominal wall repair
    U Klinge
    The Department of Surgery, IZKF BIOMAT, The Technical University of Aachen, Germany
    Biomaterials 20:613-23. 1999
    ..Whereas the addition of polyglactin filaments appears to be favourable, the coating of polypropylene with polyglactin seems to hinder the incorporation of the mesh...
  65. ncbi Postimplant behavior of lightweight polypropylene meshes in an experimental model of abdominal hernia
    Juan M Bellon
    Department of Surgery, Faculty of Medicine, Networking Research Center on Bioengineering, Biomaterials and Nanomedicine CIBER BBN, Alcala University, Alcala de Henares, Madrid, Spain
    J Invest Surg 21:280-7. 2008
    ..This study was designed to assess the biological and biomechanical behavior of these prostheses to establish whether they offer any advantages over nonabsorbable lightweight polypropylene prostheses...
  66. ncbi Surgical complications and medium-term outcome results of tension-free vaginal tape: a prospective study of 313 consecutive patients
    Ishai Levin
    Urogynecology and Pelvic Floor Unit, Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Neurourol Urodyn 23:7-9. 2004
    ..A prospective study was undertaken to examine the incidence of surgical complications and medium-term outcomes of tension-free vaginal tape (TVT) surgery in a large, heterogeneous group of stress-incontinent women...
  67. ncbi Factors that affect recurrence after incisional herniorrhaphy with prosthetic material
    A Rios
    , Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
    Eur J Surg 167:855-9. 2001
    ..01) in both the univariate and multivariate analyses. CONCLUSIONS: Patients at the greater risk of recurrence are those aged over 60 years, with large, recurrent hernias and who develop local complications during the postoperative period...
  68. ncbi Experimental comparison of monofile light and heavy polypropylene meshes: less weight does not mean less biological response
    Dirk Weyhe
    Department of Surgery, St Josef Hospital, Ruhr University, Bochum, Germany
    World J Surg 30:1586-91. 2006
    ..It is believed that biocompatibility of meshes may be improved by reducing their weight per meter squared (m2) and altering the implant structure...
  69. ncbi Three-year results of a randomized clinical trial of lightweight or standard polypropylene mesh in Lichtenstein repair of primary inguinal hernia
    S Bringman
    CLINTEC, Karolinska Institutet, Stockholm, Sweden
    Br J Surg 93:1056-9. 2006
    ..This randomized trial examined whether lightweight (LW) polypropylene mesh (large pore size, partially absorbable) could have long-term benefits in reducing chronic pain and inflammation after inguinal hernia repair...
  70. ncbi Suture versus mesh repair for incisional hernia
    Saleh M Al-Salamah
    College of Medicine, King Saud University, Department of Surgery, University Unit, Riyadh Medical Complex, PO Box 261283, Riyadh 11342, Kingdom of Saudi Arabia
    Saudi Med J 27:652-6. 2006
    ..To compare suture with mesh repair, for incisional hernia in terms of early and late outcomes...
  71. ncbi Total extraperitoneal hernioplasty: does the long-term clinical course depend on the type of mesh?
    Johannes C Lauscher
    Department of General, Vascular, and Thoracic Surgery, Charite Universitatsmedizin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    J Laparoendosc Adv Surg Tech A 18:803-8. 2008
    ....
  72. ncbi Prospective double-blind randomized controlled study comparing heavy- and lightweight polypropylene mesh in totally extraperitoneal repair of inguinal hernia: early results
    Brij B Agarwal
    Department of General Surgery, Sir Ganga Ram Hospital, New Delhi, 110060, India
    Surg Endosc 23:242-7. 2009
    ..Paucity of randomized controlled trials (RCTs) on human beings has left choice of mesh to surgeon preference or cost. We carried out a double-blind RCT comparing heavy- and lightweight PP-based meshes in TEP...
  73. ncbi Photoinitiated cross-linking of the biodegradable polyester poly(propylene fumarate). Part I. Determination of network structure
    John P Fisher
    Department of Bioengineering, Rice University, PO Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Biomacromolecules 4:1327-34. 2003
    ..Finally, this study demonstrates a method for inferring cross-linked network structures by contrasting properties of bulk materials formed from similar cross-linking initiators...
  74. ncbi Complications of synthetic graft materials used in suburethral sling procedures
    Kwong Pang Tsui
    Department of Obstetrics and Gynecology, Taichung Hospital, Department of Health, The Executive Yuan, Taiwan
    Int Urogynecol J Pelvic Floor Dysfunct 16:165-7. 2005
    ..Fibrosis and severe inflammatory reactions were found in the connective tissue adjacent to the mesh as well as the Prolene mesh. Technically, it would be easier to remove the graft of patch sling if rejection or erosion occurs...
  75. ncbi Acute inflammatory response after inguinal and incisional hernia repair with implantation of polypropylene mesh of different size
    Gaetano Di Vita
    Department of Surgery and Oncology, Division of General Surgery, University of Palermo, Palermo, Italy
    Langenbecks Arch Surg 390:306-11. 2005
    ..The purpose of this study was to assess the modifications of interleukin (IL)-6, C-reactive protein (CRP), leukocytes and fibrinogen after implantation of polypropylene mesh...
  76. ncbi Comparison of prosthetic materials in incisional hernia repair
    Uygar Demir
    Department of General Surgery, Sisli Etfal Training and Research Hospital, Istanbul, Turkey
    Surg Today 35:223-7. 2005
    ..Many different types of meshes and adhesion barriers have been developed in an attempt to overcome these problems, some of which we have assessed in a rat model...
  77. ncbi Evaluation of adhesion formation, mesh fixation strength, and hydroxyproline content after intraabdominal placement of polytetrafluoroethylene mesh secured using titanium spiral tacks, nitinol anchors, and polypropylene suture or polyglactin 910 suture
    C S Joels
    Department of General Surgery, Carolinas Medical Center, 1000 Blythe Boulevard, Charlotte, NC 28203, USA
    Surg Endosc 19:780-5. 2005
    ..The purpose of this study is to evaluate fixation methods for polytetrafluoroethylene (ePTFE) mesh with an in vivo model of laparoscopic ventral hernia repair...
  78. ncbi A new technique combining both polypropylene and vaginal wall sling procedures: can it minimize the risk of urethral and vaginal erosion occurring with synthetic materials?
    Levent Emir
    I Clinic of Urology, Ankara Teaching and Research Hospital, Ministry of Health, Ankara, Turkey
    World J Urol 23:221-4. 2005
    ..The other advantage of this technique is the concomitant utilization of the vaginal wall as sling material...
  79. ncbi Open Rives-Stoppa ventral hernia repair made simple and successful but not for everyone
    L Heartsill
    Department of Surgery, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229 3900, USA
    Hernia 9:162-6. 2005
    ..Recurrence rates are 0-8%. We proposed that the operation could be done with equal success by placing the mesh in an intraperitoneal position and primarily closing the fascia anterior to the mesh...
  80. ncbi Ring-reinforced prosthesis for paracolostomy hernia
    P de Ruiter
    Department of Surgery, Medical Center Alkmaar, Alkmaar, The Netherlands
    Dig Surg 22:152-6. 2005
    ..We developed a polypropylene mesh prosthesis with a central opening, reinforced with a polypropylene ring, that can be implanted suprafascially through a mucocutaneous incision...
  81. ncbi [Effectiveness of hernioplasty with using a polypropylene mesh implant in treatment of postoperative ventral hernias]
    V M Sedov
    Vestn Khir Im I I Grek 164:85-7. 2005
    ..Long-term results of the operative treatment were analyzed in terms from 1 year to 3 years in 16 patients aged from 40 to 73 years of age (mean age 58+/-2.6 years) with great and giant postoperative hernias. No recurrences were noted...
  82. ncbi [Real-time monitoring of the peritoneal behavior of composite prostheses by sequential laparoscopy: applicability in ventral hernia repair]
    Juan M Bellon
    Departamento de Cirugia, Facultad de Medicina, Universidad de Alcala, Alcala de Henares, Madrid, Espana
    Cir Esp 82:290-6. 2007
    ..This study was designed to assess the behavior at the peritoneal interface of several composite prostheses using sequential laparoscopy to monitor the real-time adhesion formation process...
  83. ncbi [Treatment of large postoperative hernias using intraperitoneal meshes]
    Piotr Trojanowski
    Wojskowy Instytut Medyczny w Warszawie, Klinika Chirurgii Ogólnej, Onkologicznej i Klatki Piersiowej CSK MON
    Pol Merkur Lekarski 22:376-8. 2007
    ....
  84. ncbi Inguinal hernia treatment with Prolene hernia system in a Dutch regional training hospital
    Arthur I Gilbert
    Hernia Institute of Florida, 6250 Sunset Drive 200, Miami, FL 33143, USA
    Hernia 11:297. 2007
  85. ncbi Open and laparoscopic approach in incisional hernia repair with ePTFE prosthesis
    George N Zografos
    3rd Department of Surgery, Athens General Hospital, Athens, Greece
    J Laparoendosc Adv Surg Tech A 17:277-81. 2007
    ..The aim of this retrospective study was to analyze the results of incisional hernia laparoscopic and open surgery, focusing on the morbidity and postoperative implications...
  86. ncbi Inguinal hernia treatment with the Prolene Hernia System in a Dutch regional training hospital
    C A S Berende
    Department of Surgery, Jeroen Bosch Hospital, Nieuwstraat 34, 5211 s Hertogenbosch, The Netherlands
    Hernia 11:303-6. 2007
    ..In this retrospective study results from inguinal hernia repair with the Prolene Hernia System (PHS) in a regional training hospital were analysed...
  87. ncbi Tensile strength and host response towards different polypropylene implant materials used for augmentation of fascial repair in a rat model
    Maja L Konstantinovic
    Centre for Surgical Technologies, Faculty of Medicine, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Int Urogynecol J Pelvic Floor Dysfunct 18:619-26. 2007
    ..At 90 days time point, explants reconstructed with tighter woven multifilament SPM were weaker than sutured or SPMM controls. Overall shrinkage of 10% was comparable for all groups...
  88. ncbi Influence of hernioplastic implants on male fertility in rats
    T Kolbe
    Institute of Laboratory Animal Science and Research Center Biomodels, University of Veterinary Medicine, Vienna, Austria
    J Biomed Mater Res B Appl Biomater 81:435-40. 2007
    ..Both types of hernioplastic implants tested in this investigation do not give an indication of a negative influence on male fertility in juvenile or adult rats...
  89. ncbi Strength of tissue attachment to mesh after ventral hernia repair with synthetic composite mesh in a porcine model
    S Majercik
    Department of Surgery, Rhode Island Hospital Brown University, 2 Dudley St, Suite 470, Providence, RI 02905, USA
    Surg Endosc 20:1671-4. 2006
    ..A prospective animal study involving 12 female swine aimed to measure the strength of tissue attachment to composite mesh at various time points after laparoscopic ventral hernia repair in a porcine model...
  90. ncbi Prospective evaluation of adhesion formation and shrinkage of intra-abdominal prosthetics in a rabbit model
    Andrew G Harrell
    Carolinas Hernia Center, Division of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, Charlotte, North Carolina 28203, USA
    Am Surg 72:808-13; discussion 813-4. 2006
    ..Each prosthetic generates a varied host reaction. Better understanding of these reactions can allow a suitable prosthetic to be chosen for a given patient in clinical practice...
  91. ncbi The role of bovine preserved peritoneum in rats ventral hernia: a histological evaluation
    Eduardo Lemos de Souza Bastos
    Postgraduate Program in Surgery and Experimentation, Federal University of Sao Paulo UNIFESP, Rua Carlos Botelho 246, 17515 240 Marília SP, Brazil
    Acta Cir Bras 21:328-31. 2006
    ..To assess the role of preserved bovine parietal peritoneum as a material for hernia repair in a rat ventral hernia model...
  92. ncbi Lightweight partially absorbable monofilament mesh (polypropylene/poliglecaprone 25) for TAPP inguinal hernia repair: initial experience
    Ferdinando Agresta
    Department of General Surgery, Ospedale Civile, Via Forlanini, 71, 31029 Vittorio Veneto, Italy
    Surg Laparosc Endosc Percutan Tech 17:91-4. 2007
    ....
  93. ncbi Hernioplasty with bilayer polypropylene mesh: a new tension-free technique
    J P Zhou
    Department of Geriatrics Surgery, Second Xiangya Hospital of Center South University, Changsha, People s Republic of China
    Hernia 10:385-8. 2006
    ....
  94. ncbi On the use of unsealed polypropylene mesh as tracheal replacement
    Matthias Behrend
    Klinik für Viszeral, Thorax, GefaSS und Kinderchirurgie, Klinikum Deggendorf, Germany
    ASAIO J 52:328-33. 2006
    ..Nevertheless, the results show that replacement of the cervical trachea with a polypropylene mesh can be successful under different experimental conditions...
  95. ncbi [Surgical training and inguinal hernia repair]
    R Cueto Rozon
    Service de Chirurgie Digestive, CHU Jean Verdier, Universite Paris XIII, UFR de Bobigny, Avenue du 14 Juillet, 93140 Bondy, France
    Ann Chir 131:311-5. 2006
    ..To evaluate influence of surgical experience on inguinal hernia repair...
  96. ncbi Collagen foil (TissuFoil E) reduces the formation of adhesions when using polypropylene mesh for the repair of experimental abdominal wall defects
    Frank Schönleben
    Chirurgische Klinik mit Poliklinik der Universität Erlangen Nürnberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Int J Colorectal Dis 21:840-6. 2006
    ..Severe adhesions are a common cause of intestinal obstruction, or even intestinal fistulas. Using a porcine model, we investigated whether applying a collagen foil (CF) to the undersurface of a PPM will reduce adhesion formation...
  97. ncbi Suitability of different sling materials for the treatment of female stress urinary incontinence
    Kathleen C Kobashi
    Continence Center, Virginia Mason Medical Center, Seattle, WA 98111, USA
    Nat Clin Pract Urol 2:84-91. 2005
    ..Long-term data on efficacy is lacking, but early results with new materials and delivery techniques indicate that excellent cure rates with minimal morbidity and high patient satisfaction may be achievable...
  98. ncbi Cross-linked acellular porcine dermal collagen implant in laparoscopic ventral hernia repair: case-controlled study of operative variables and early complications
    Gary A Cobb
    Roosevelt Surgical Associates, Inc, 4040 Roosevelt Blvd, Middletown, OH 45044, USA
    Int Surg 90:S24-9. 2005
    ..The referring surgeon removed the CPDC implant in one case upon diagnosis of wound infection. CPDC is safe for use in LVHR and offers an alternative to composite PP/ePTFE mesh that warrants further investigation...
  99. ncbi Day hospital for incisional hernia repair: selection criteria
    M Donati
    Department of Surgical Sciences and Organ Transplant, Hernia Service, Catania, Italy
    Acta Chir Belg 108:198-202. 2008
    ..The authors report their experience with incisional hernia repair and set criteria for the safe performance of the procedure on a day hospital basis...
  100. ncbi [Results of laparoscopic repair of abdominal wall hernias using an ePTFE-polypropylene composite mesh]
    I Gal
    Department of Surgery, Bugat Pal Hospital, Gyongyos, Hungary
    Zentralbl Chir 129:92-5. 2004
    ..For this purpose an ePTFE mesh is generally used. There are limited reported clinical data regarding the long-term results and benefits of other biomaterials...
  101. ncbi Temporary closure of the abdomen using a new composite prosthesis (PL-PU99)
    Juan M Bellon
    Departamento de Cirugia, Facultad de Medicina, Universidad de Alcala, Campus Universitario, Ctra Madrid Barcelona Km 33 600, E 28871 Alcala de Henares, Madrid, Spain
    Am J Surg 188:314-20. 2004
    ..Temporary abdominal wound closure is sometimes desirable when tension-free approximation of the wound edges is impractical or when reexploration is planned...

Research Grants56

  1. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2007
    ..5 million patients undergo hernia repair procedures each year. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. Complex Ventral Hernia Repair
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
    ..The specific hypothesis driving the research proposal is that the use of a permanent, synthetic prosthetic for the one-stage repair of complex ventral hernias will result in superior outcomes compared to use of a biologic prosthetic. ..
  3. Engineered Biologics for Repair of Abdominal Wall Musculofascia
    Anshu B Mathur; Fiscal Year: 2013
    ....
  4. Absorbable Triphasic Hernial Meshes
    Shalaby W Shalaby; Fiscal Year: 2010
    ....
  5. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2010
    ..abstract_text> ..
  6. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2013
    ..abstract_text> ..
  7. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2012
    ..abstract_text> ..
  8. PumpKIN PreClinical
    Mark Gartner; Fiscal Year: 2011
    ..abstract_text> ..
  9. Advanced Energy Storage Film Capacitors for Automated External Defibrillators
    Shihai Zhang; Fiscal Year: 2011
    ..This will enable the deployment of AED in millions of homes of patients with heart arrhythmia problem who are facing the threat of delayed defibrillation if AED not available. ..
  10. Surface Enhanced Biocompatible Blood Oxygenators
    Daniel Campos; Fiscal Year: 2010
    ..In addition, they will provide a key element for long term blood oxygenation associated with extracorporeal membrane oxygenation, acute respiratory distress syndrome, and artificial lungs. ..
  11. SURGERY FOR ACUTE MYOCARDIAL INFARCTION
    L Edmunds; Fiscal Year: 2000
    ....
  12. A new absorbable mesh for hernia repair
    David Martin; Fiscal Year: 2004
    ....
  13. LOW-DOSE RADIATION STERILIZATION
    SHALABY SHALABY; Fiscal Year: 2000
    ..The long-term impact will be the availability of a new, low-dose radiation process for radiation-sensitive devices which represent a major milestone in sterilization technology. ..
  14. LOW-DOSE RADIATION STERILIZATION
    SHALABY SHALABY; Fiscal Year: 2003
    ..abstract_text> ..
  15. OLIGONUCLEOTIDE INHIBITION OF CELL PROLIFERATION
    Eric Wickstrom; Fiscal Year: 2000
    ..The lead compounds resulting from these studies will then be translated to a separate collaborative application for a Phase I/II clinical trial. ..
  16. EXPANDING BONE CEMENT FOR TUBULAR HAND FRACTURES
    David Hile; Fiscal Year: 2001
    ..Our concept of an injectable, space-filling cement addresses restoration of both the bones and the surrounding soft-tissue envelope with the goal of early restoration of joint movement and complete rehabilitation. ..
  17. Layered Manufacture of Bioactive Porous TE Scaffolds
    Malcolm Cooke; Fiscal Year: 2009
    ..This research will develop manufacturing and biological strategies to produce bioactive patient-specific scaffolds for the repair of maxiliofacial bone defects. ..
  18. LARGE SCALE SYNTHESIS OF THE OPIOID PEPTIDE DPDPE
    Richard Houghten; Fiscal Year: 1991
    ..Due to the high cost of the amino acid D-penicillamine (pen) and the disulfide bridge in the peptide, this synthesis will be an exacting test of the methods to be used during the proposed Phase I portion of this research...
  19. OSTEOCONDUCTIVE SCAFFOLD FOR CORTICAL BONE ALLOGRAFTS
    DEBRA TRANTOLO; Fiscal Year: 2000
    ..If as successful as proposed, the clinical outcomes of our system will be uniquely successful commercially. ..
  20. Latent-Reactive Reagents for Biomaterial Surface Coating
    PATRICK GUIRE; Fiscal Year: 2002
    ..260 million dollars, not subject to surface modification with current commercial coating technology. ..
  21. OCULAR INSERT FOR THE TREATMENT OF GLAUCOMA
    CHARLES LEAHY; Fiscal Year: 2001
    ..Define a prototype design for a polymeric insert of the human inferior conjunctival sac. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  22. Linear-Dendritic Copolymers as Tissue Growth Scaffolds
    TIMOTHY PATTEN; Fiscal Year: 2005
    ..Methods are outlined to characterize the assembly of the polymers into hydrogels and the efficacy of the materials in tissue culture. ..
  23. PATHOGEN-PROTECTIVE COATINGS FOR MEDICAL FABRICS
    Melvin Swanson; Fiscal Year: 1993
    ..These reagents will then be applied as a thin layer onto one side of the hydrophilic fabrics and liquid repellency measured (including alcohol and soap solutions)...
  24. High Flux Blood Oxygenators
    LAURA CARMICHAEL; Fiscal Year: 2006
    ..The new family of membranes is also expected to have superior blood wet out resistance. Compact Membrane Systems, Inc. [unreadable] [unreadable] [unreadable]..
  25. Simplified Pump Oxygenator for Pediatric Use Phase II
    Mark Gartner; Fiscal Year: 2003
    ..If successful, Ension believes that this product would receive quick acceptance by pediatric perfusionists throughout the medical community. ..
  26. Lightweight, Compliant Manual Wheelchair High-Tone Child
    MATTHEW HERMES; Fiscal Year: 2006
    ..metal wheelchair devices can lead to consideration of new designs in synthetic materials throughout the medical device industry thus broadly benefiting medical care. [unreadable] [unreadable]..
  27. Latent Reactive Groups for Biomaterials
    PATRICK GUIRE; Fiscal Year: 2005
    ..This innovative approach to activation of radical generators is expected to facilitate the surface modification of "inert" medical devices, which cannot be activated with long-wavelength photons for external light sources. ..
  28. Polymeric Reinforcement of Degradable Bone Plates
    DEBRA TRANTOLO; Fiscal Year: 2001
    ..A reinforced, but still resorbable, fixation device that can ameliorate tendencies of plate deformation would address the clinical demand for resorbable orthopedic fixtures. ..
  29. UNIVERSAL CONTAMINATION-PREVENTING PIPET TIPS FOR PCR
    WILLIAM MACCONNELL; Fiscal Year: 1991
    ..Furthermore these tips will be more cost effective and convenient than the current positive-displacement pipets used to prevent contamination in PCR work...
  30. AN ULTRA HIGH THROUGHPUT SYSTEM FOR DRUG DISCOVERY
    SARAH SPORN; Fiscal Year: 1999
    ..The proposed ultra-high throughput system is aimed at meeting those requirements by providing a low volume assay system that will be capable of screening over 100,000 compounds per day. ..
  31. Instrumentation For High-Resolution Analysis of Cancer
    John Zebala; Fiscal Year: 2007
    ..Syntrix will commercialize the PhotoBlaster system that results from this research either through direct sales or through third-parties. ..
  32. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....
  33. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  34. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  35. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  36. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  37. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  38. ADIPOSE DERIVED STEM CELLS FOR TREATMENT OF INCONTINENCE
    LARISSA RODRIGUEZ; Fiscal Year: 2008
    ..Lastly, we will use an animal model of incontinence and decreased urethral resistance to test the hypothesis that these cells can be used to reconstruct a functional urethra as a treatment of stress incontinence. ..
  39. SkyScan 1172 High-resolution desk-top micro-CT system
    James Williams; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. NanobioReactor for monitoring small cell populations
    Ales Prokop; Fiscal Year: 2003
    ..abstract_text> ..
  41. Optimizing Testis Transplantation to Study RET Signaling
    Cathy Naughton; Fiscal Year: 2005
    ..Determining how Ret affects testicular function will add to our understanding of human male infertility and may provide an avenue for new treatment strategies for infertile men with nonobstructive azoospermia. ..
  42. KINEMATICS AND STABILITY OF THE ARCH OF THE FOOT
    Harold Kitaoka; Fiscal Year: 2001
    ..abstract_text> ..
  43. FOOT AND ANKLE BIOMECHANICS WITH ORTHOSIS AMBULATION
    Harold Kitaoka; Fiscal Year: 2001
    ..In addition to patients with arthritis, these orthoses will be useful for patients with ankle instability, subtalar instability, and neuromuscular disorders. ..
  44. Motor adaptation during human locomotion
    DANIEL FERRIS; Fiscal Year: 2005
    ..In addition to providing important insight into the neural control of human locomotion, the project will advance robotic technologies for assisting gait rehabilitation and controlling powered lower limb prostheses. ..
  45. The Role of RET in Spermatogenesis
    Cathy Naughton; Fiscal Year: 2005
    ..The translation to human disease will be achieved by studying RET expression in male infertility cases of maturation arrest. ..
  46. Biopolymer Surfactants for Sealing Electroporated Membranes
    RAPHAEL CARL LEE; Fiscal Year: 2010
    ..Finally, we will conduct studies in parallel to determine if surfactant rescued cells manifest normal phenotype during proliferation or exhibit effects of mutations caused by unrepaired DMA. ..
  47. Cross-linked Polymer Micelles in Cancer Therapy
    Tatiana K Bronich; Fiscal Year: 2010
    ..It is anticipated that these studies will lead to the design of new formulation of cisplatin for improved cancer treatment. ..
  48. Anti-larval measures for malaria control in The Gambia
    Steven Lindsay; Fiscal Year: 2007
    ..The results from this study will make a major contribution to quantifying the importance of the use of Bs and Bti in the fight against malaria. ..
  49. Estrogen Influences on Fetal Adrenocorticotropin
    Charles Wood; Fiscal Year: 2006
    ..abstract_text> ..
  50. Mechanism of in-vitro aging
    LYSLE LEWIS; Fiscal Year: 2007
    ..The proposed research will enhance our understanding of events that occur as a consequence of shortened chromosomes and factors that affect the rate of shortening. [unreadable] [unreadable] [unreadable]..
  51. Homocysteine/Hypertension & Vascular Lesion Formation
    Peter Lin; Fiscal Year: 2008
    ..abstract_text> ..
  52. ELECTRIC INJURY--IMAGING OF THERMAL/NON-THERMAL ASPECTS
    Raphael Lee; Fiscal Year: 2003
    ..abstract_text> ..
  53. IMPACT OF MENOPAUSE ON VAGINAL CONNECTIVE TISSUE SUPPORT
    Pamela Moalli; Fiscal Year: 2008
    ..abstract_text> ..
  54. SHORT-TERM RESEARCH TRAINING FOR MINORITY STUDENTS
    Charles Wood; Fiscal Year: 2008
    ..The emphasis of this training program in the next five years will be to significantly expand the students' horizons and to recruit students into basic biomedical science. ..
  55. EVAPORATIVE LOSSES FROM SEMI-VOLATILE MIST SAMPLES
    Peter Raynor; Fiscal Year: 2002
    ..Reevaluated data may be able to be used more effectively in epidemiological studies on the health effects of metalworking fluid mists. ..
  56. Volume-Outcomes in Incontinence Surgery
    Jennifer Anger; Fiscal Year: 2005
    ..The primary outcome will be re-operation rates, repeat sling procedures (for failures), and other postoperative complications, stratified by high and low volume surgeons and hospitals. ..