polyurethanes

Summary

Summary: A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.

Top Publications

  1. ncbi Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites
    Ebru Urcan
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstrasse 26, D 80336 Munich, Germany
    Biomaterials 31:2010-4. 2010
  2. ncbi Current status of prosthetic bypass grafts: a review
    Ruben Y Kannan
    Biomaterials and Tissue Engineering Centre, University Department of Surgery, Royal Free and University College Medical School, University College London, UK
    J Biomed Mater Res B Appl Biomater 74:570-81. 2005
  3. ncbi Development of a new lacrimal drainage conduit using POSS nanocomposite
    Karla Chaloupka
    Department of Ophthalmology, University Eye Hospital Zurich, Zurich, Switzerland
    Biotechnol Appl Biochem 58:363-70. 2011
  4. ncbi Prospective, double-blind, randomized trial evaluating patient satisfaction, bleeding, and wound healing using biodegradable synthetic polyurethane foam (NasoPore) as a middle meatal spacer in functional endoscopic sinus surgery
    Nael Shoman
    St Paul Sinus Centre, Vancouver, BC, Canada
    J Otolaryngol Head Neck Surg 38:112-8. 2009
  5. ncbi Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay
    Norbert H Kleinsasser
    Klinisch experimentelle Onkologie, Department of Otolaryngology Head and Neck Surgery, Ludwig Maximilians University Munich, Munich, Germany
    J Dent 32:229-34. 2004
  6. pmc Identification of flame retardants in polyurethane foam collected from baby products
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 45:5323-31. 2011
  7. ncbi The degradative resistance of polyhedral oligomeric silsesquioxane nanocore integrated polyurethanes: an in vitro study
    Ruben Y Kannan
    Biomaterials and Tissue Engineering Centre BTEC, Academic Division of Surgical and Interventional Sciences, University College London, Rowland Hill, Hampstead, London NW3 2PF, UK
    Biomaterials 27:1971-9. 2006
  8. ncbi Nano-structured polymers enhance bladder smooth muscle cell function
    Anil Thapa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
    Biomaterials 24:2915-26. 2003
  9. ncbi The role of polymer nanosurface roughness and submicron pores in improving bladder urothelial cell density and inhibiting calcium oxalate stone formation
    Young Wook Chun
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Nanotechnology 20:085104. 2009
  10. ncbi The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial
    Bo Jørgensen
    Copenhagen Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark
    Int Wound J 2:64-73. 2005

Detail Information

Publications292 found, 100 shown here

  1. ncbi Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites
    Ebru Urcan
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstrasse 26, D 80336 Munich, Germany
    Biomaterials 31:2010-4. 2010
    ..25 and 0.5gamma-H2AX foci/HGF cell. Our results for the first time show that exposure to dental resin monomers can induce DSBs in primary human oral cavity cells, which underscores their genotoxic capacity...
  2. ncbi Current status of prosthetic bypass grafts: a review
    Ruben Y Kannan
    Biomaterials and Tissue Engineering Centre, University Department of Surgery, Royal Free and University College Medical School, University College London, UK
    J Biomed Mater Res B Appl Biomater 74:570-81. 2005
    ..In view of the advances in tissue engineering, this makes possible the creation of an ideal off-the-shelf bypass graft. We present a broad overview of the current state of prosthetic bypass grafts...
  3. ncbi Development of a new lacrimal drainage conduit using POSS nanocomposite
    Karla Chaloupka
    Department of Ophthalmology, University Eye Hospital Zurich, Zurich, Switzerland
    Biotechnol Appl Biochem 58:363-70. 2011
    ..Finally, the coagulation and cast technique were selected to construct an LDC superior to its predecessors, and its advantages highlighted...
  4. ncbi Prospective, double-blind, randomized trial evaluating patient satisfaction, bleeding, and wound healing using biodegradable synthetic polyurethane foam (NasoPore) as a middle meatal spacer in functional endoscopic sinus surgery
    Nael Shoman
    St Paul Sinus Centre, Vancouver, BC, Canada
    J Otolaryngol Head Neck Surg 38:112-8. 2009
    ....
  5. ncbi Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay
    Norbert H Kleinsasser
    Klinisch experimentelle Onkologie, Department of Otolaryngology Head and Neck Surgery, Ludwig Maximilians University Munich, Munich, Germany
    J Dent 32:229-34. 2004
    ..Whereas the cytotoxic potential of some components has been clearly documented, possible genotoxicity in human target cells demands further investigation...
  6. pmc Identification of flame retardants in polyurethane foam collected from baby products
    Heather M Stapleton
    Nicholas School of the Environment, Duke University, Durham, North Carolina, USA
    Environ Sci Technol 45:5323-31. 2011
    ..Future studies are therefore warranted to specifically measure infants exposure to these flame retardants from intimate contact with these products and to determine if there are any associated health concerns...
  7. ncbi The degradative resistance of polyhedral oligomeric silsesquioxane nanocore integrated polyurethanes: an in vitro study
    Ruben Y Kannan
    Biomaterials and Tissue Engineering Centre BTEC, Academic Division of Surgical and Interventional Sciences, University College London, Rowland Hill, Hampstead, London NW3 2PF, UK
    Biomaterials 27:1971-9. 2006
    ..b>Polyurethanes being one of the most compliant polymers known are as such, the natural choice to build such constructs...
  8. ncbi Nano-structured polymers enhance bladder smooth muscle cell function
    Anil Thapa
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 1296, USA
    Biomaterials 24:2915-26. 2003
    ..This claim is supported by the fact that cell number was enhanced on nano-structured compared to conventional PLGA and PU once chemistry changes were eliminated using casting techniques...
  9. ncbi The role of polymer nanosurface roughness and submicron pores in improving bladder urothelial cell density and inhibiting calcium oxalate stone formation
    Young Wook Chun
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Nanotechnology 20:085104. 2009
    ..Thus, results from the present study suggest the importance of nanometer topographical cues for designing better materials for bladder tissue engineering applications...
  10. ncbi The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial
    Bo Jørgensen
    Copenhagen Wound Healing Centre, Bispebjerg University Hospital, Copenhagen, Denmark
    Int Wound J 2:64-73. 2005
    ..The results of this randomised, controlled study suggest an important role of sustained silver-releasing dressings in the treatment of critically colonised chronic wounds...
  11. ncbi Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications
    Joanne E McBane
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5G1G6, Canada
    Biomaterials 32:6034-44. 2011
    ....
  12. ncbi Synthesis, characterization, and in vitro activity of antibiotic releasing polyurethanes to prevent bacterial resistance
    V Ruggeri
    Department of Chemistry, University of Rome La Sapienza, P le Aldo Moro 5, 00185, PO BOX no 34, Roma 62, Italy
    J Biomed Mater Res A 81:287-98. 2007
    ..Thus, in order to obtain high antimicrobial-polymer affinity we synthesized or modified polyurethanes to introduce different functional groups...
  13. ncbi Endothelium regeneration on luminal surface of polyurethane vascular scaffold modified with diamine and covalently grafted with gelatin
    Yabin Zhu
    Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
    Biomaterials 25:423-30. 2004
    ..Therefore, the aminolysis and the following biomacromolecule immobilization is a promising way to enhance the cell-PU interaction that can accelerate the endothelium regeneration, which is crucial for blood vessel tissue engineering...
  14. ncbi Decreased fibroblast cell density on chemically degraded poly-lactic-co-glycolic acid, polyurethane, and polycaprolactone
    Rylie J Vance
    Department of Biomedical Engineering, Purdue University, 1296 Potter Building, West Lafayette, IN 47907 1296, USA
    Biomaterials 25:2095-103. 2004
    ....
  15. ncbi In vitro and in vivo cartilage engineering using a combination of chondrocyte-seeded long-term stable fibrin gels and polycaprolactone-based polyurethane scaffolds
    Daniela Eyrich
    Department of Pharmaceutical Technology, University of Regensburg, Regensburg, Germany
    Tissue Eng 13:2207-18. 2007
    ..The presented composite system is suggested as a promising alternative toward clinical application of engineered cartilaginous tissue for plastic and reconstructive surgery...
  16. ncbi Synthesis, characterizations and biocompatibility of alternating block polyurethanes based on P3/4HB and PPG-PEG-PPG
    Guangyao Li
    Multidisciplinary Research Center, Shantou University, Daxue Lu 243, Shantou, Guangdong 515063, China
    J Biomed Mater Res A 98:88-99. 2011
    Block copolymers with exactly controlled structures, that is, alternating block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutrate) (P3/4HB-diol) and poly (propylene glycol)-poly(ethylene glycol)-poly(propylene glycol) (..
  17. ncbi Tissue response to poly(ether)urethane-polydimethylsiloxane-fibrin composite scaffolds for controlled delivery of pro-angiogenic growth factors
    Paola Losi
    Laboratory for Biomaterials and Graft Technology, Institute of Clinical Physiology, CNR, Via Aurelia Sud, 54100 Massa, Italy
    Biomaterials 31:5336-44. 2010
    ..In conclusion, this study showed that the semi-IPN composite scaffold acting as a pro-angiogenic GFs delivery system has therapeutic potential for the local treatment of ischemic tissue and wound healing...
  18. ncbi Alternative block polyurethanes based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(ethylene glycol)
    Jueyu Pan
    Multidisciplinary Research Center, Shantou University, Daxue Lu 243, Shantou, Guangdong 515063, China
    Biomaterials 30:2975-84. 2009
    ..The thermal property was studied by DSC and TGA. Platelet adhesion study revealed that the alternative block polyurethanes possess excellent hemocompatibility...
  19. ncbi Small calibre polyhedral oligomeric silsesquioxane nanocomposite cardiovascular grafts: influence of porosity on the structure, haemocompatibility and mechanical properties
    Maqsood Ahmed
    Centre for Nanotechnology and Regenerative Medicine, University College London, London, UK
    Acta Biomater 7:3857-67. 2011
    ..Whilst the different graft samples induced varying levels of cytokine secretion in vitro, no distinct pattern suggesting a non-trivial relationship was observed...
  20. ncbi Surface modification of POSS-nanocomposite biomaterials using reactive oxygen plasma treatment for cardiovascular surgical implant applications
    Atefeh Solouk
    Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London UCL, UK
    Biotechnol Appl Biochem 58:147-61. 2011
    ..Such materials enhanced the EC response and promoted endothelialization on optimized films, thus demonstrating their use as bypass graft materials...
  21. ncbi Potential of silver nanoparticle-coated polyurethane foam as an antibacterial water filter
    Prashant Jain
    Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600036, India
    Biotechnol Bioeng 90:59-63. 2005
    ..Combined with the low cost and effectiveness in its applications, the technology may have large implications to developing countries...
  22. pmc Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes
    G Donelli
    Department of Technologies and Health, Istituto Superiore di Sanita, Viale Regina Elena, Rome, Italy
    Antimicrob Agents Chemother 51:2733-40. 2007
    ..We showed that our functionalized polyurethanes could adsorb a significant amount of dispersin B, which was able to exert its hydrolytic activity against the ..
  23. ncbi Comparison between polyurethanes containing castor oil (soft segment) and cancellous bone autograft in the treatment of segmental bone defect induced in rabbits
    Oduvaldo Câmara Marques Pereira-Junior
    Department of Veterinary Surgery and Anesthesiology, Faculty of Veterinary, Medicine and Animal Science, Sau Paulo University, Rubiãc Júnior, Botucatu, SP, Brazil
    J Biomater Appl 21:283-97. 2007
    The aim of this study is to compare polyurethanes containing castor oil (soft segment) in granular form compared to cancellous bone autograft applied to a segmental bone defect...
  24. ncbi Potential role of fire retardant-treated polyurethane foam as a source of brominated diphenyl ethers to the US environment
    Robert C Hale
    Department of Environmental Sciences, Virginia Institute of Marine Science, College of William and Mary, Gloucester Point 23062, USA
    Chemosphere 46:729-35. 2002
    ..Subsequent dispersal of these penta-containing foam fragments may be one mechanism by which these BDEs reach the environment...
  25. ncbi Toward the next-generation nanomedicines: design of multifunctional multiblock polyurethanes for effective cancer treatment
    Mingming Ding
    College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
    ACS Nano 7:1918-28. 2013
    ..approach for the design and fabrication of smart intracellular targeted nanovehicles for effective cancer treatment, and opens a new era in the development of biodegradable polyurethanes for next-generation nanodelivery systems.
  26. ncbi Ability of polyurethane foams to support cell proliferation and the differentiation of MSCs into osteoblasts
    M Zanetta
    Department of Bioengineering, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy
    Acta Biomater 5:1126-36. 2009
    ..Both PU foams therefore appeared to stimulate cell adhesion and proliferation in vitro, sustaining the MSCs' growth and differentiation into osteoblasts...
  27. ncbi Novel electrospun polyurethane/gelatin composite meshes for vascular grafts
    Nicola Detta
    Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications, UdR INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56122, San Piero a Grado, Pisa, Italy
    J Mater Sci Mater Med 21:1761-9. 2010
    ..Results suggest that composite Tecoflex-Gelatin meshes could be promising alternatives to conventional vascular grafts, deserving of further studies on both their mechanical behaviour and smooth muscle cell compatibility...
  28. ncbi Polyurethanes in biomedical applications
    Ayer Burke
    European University of Lefke, Faculty of Architecture and Engineering Department of Electrical and Electronic Engineering, Turkish Republic of Northern Cyprus, Turkey
    Adv Exp Med Biol 553:83-101. 2004
  29. ncbi Evaluation of in situ curable biodegradable polyurethanes containing zwitterion components
    Raju Adhikari
    CSIRO Molecular and Health Technologies, Clayton South, Vic, Australia
    J Mater Sci Mater Med 21:1081-9. 2010
    ..Subcutaneous implantation of these polymers into rats confirmed that the polymers degraded slowly. Only a very mild inflammatory response was observed and the polymers were able to support new, well vascularised tissue formation...
  30. ncbi The behavior of endothelial cells on polyurethane nanocomposites and the associated signaling pathways
    Huey Shan Hung
    Center of Tissue Engineering and Stem Cells Research, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomaterials 30:1502-11. 2009
    ..5 ppm was observed in FAK-GFP transfected ECs. It was concluded that PU-Au nanocomposites activated FAK and the PI3K/Akt signaling pathway in ECs, leading to proliferation and migration of ECs on these surfaces...
  31. ncbi Pollen-imprinted polyurethanes for QCM allergen sensors
    Michael Jenik
    Department of Analytical Chemistry and Food Chemistry, University of Vienna, Waehringer Strasse 38, 1090, Vienna, Austria
    Anal Bioanal Chem 394:523-8. 2009
    ..When the amount of pollen grains on the electrode surface exceeds the number of available imprints, the excess particles move freely, resulting in positive, non-Sauerbrey frequency shifts...
  32. ncbi Isolation of methylene dianiline and aqueous-soluble biodegradation products from polycarbonate-polyurethanes
    Y W Tang
    Department of Biomaterials, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ont, Canada M5G 1G6
    Biomaterials 24:2805-19. 2003
    Polycarbonate-polyurethanes (PCNUs) have provided the medical device industry with practical alternatives to oxidation-sensitive polyether-urethanes (PEUs)...
  33. ncbi Synthesis and characterisation of enhanced barrier polyurethane for encapsulation of implantable medical devices
    Nima Roohpour
    Interdisciplinary Research Centre in Biomedical Materials, School of Engineering and Material Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
    J Mater Sci Mater Med 20:1803-14. 2009
    ..b>Polyurethanes have been used as biocompatible membranes for decades...
  34. ncbi Polyurethane foam/spheroid culture system using human hepatoblastoma cell line (Hep G2) as a possible new hybrid artificial liver
    Y Yamashita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cell Transplant 10:717-22. 2001
    ..These results indicate the possibility of the development of a multicapillary PUF (MC-PUF) packed-bed culture system of hepatocyte spheroids as a HALSS using Hep G2...
  35. ncbi Tissue engineering of a hybrid bypass graft for coronary and lower limb bypass surgery
    S T Rashid
    Biomaterial and Tissue Engineering Centre, Royal Free and University College Medical School, University College London, London, UK
    FASEB J 22:2084-9. 2008
    ..This is probably because the mechanical stimuli orient cells and increase the release of matrix proteins and attachment factors. The stage is now set for developing a hybrid graft for in vivo studies...
  36. ncbi Effect of different gamma-irradiation doses on cytotoxicity and material properties of porous polyether-urethane polymer
    H J Haugen
    Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, PO Box 1109 Blindern, NO 0317 Oslo, Norway
    J Biomed Mater Res B Appl Biomater 80:415-23. 2007
    ..It is recommended that TPU produced with the described foaming method should be sterilized by gamma-irradiation at 25 kGy or higher doses...
  37. ncbi Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study
    K C Münter
    Ghent University Hospital, Ghent, Belgium
    J Wound Care 15:199-206. 2006
    ..To compare the effect of the sustained silver-releasing foam dressing Contreet Foam (ColoplastA/S) with local best practice (LBP) on delayed healing ulcers using a real-life setting...
  38. ncbi Biodegradable polyurethanes: synthesis and applications in regenerative medicine
    Scott A Guelcher
    Department of Chemical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    Tissue Eng Part B Rev 14:3-17. 2008
    Biostable polyurethanes (PURs) have been incorporated in biomedical devices since the 1960s. The mechanisms of degradation and compositions with improved in vivo biostability have been investigated extensively...
  39. ncbi In vitro stability of polyether and polycarbonate urethanes
    M C Tanzi
    Bioengineering Department, Polytechnic of Milan, Milano, Italy
    J Biomater Appl 14:325-48. 2000
    ..When the oxidative test was applied to catheters made of a PEU and a PCU, the results confirmed the better stability of poly-carbonate-urethanes...
  40. ncbi Gold nanoparticles induce surface morphological transformation in polyurethane and affect the cellular response
    Shan Hui Hsu
    Department of Chemical Engineering, Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC
    Biomacromolecules 9:241-8. 2008
    ..The different cellular response on PU-Au nanocomposites was attributed to the extensively modified surface morphology and phase separation in the presence of a small amount of Au nanoparticles...
  41. ncbi The interaction between hydrolytic and oxidative pathways in macrophage-mediated polyurethane degradation
    Joanne E McBane
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Biomed Mater Res A 82:984-94. 2007
    Although relatively resistant to oxidation, polycarbonate-based polyurethanes (PCNUs) are degraded by monocyte-derived macrophages (MDM) by a co-mediated mechanism involving both hydrolytic and oxidative pathways...
  42. ncbi Evaluation of a new silver foam dressing in patients with critically colonised venous leg ulcers
    I Lazareth
    I Vascular Unit, St Joseph Hospital, Paris, France
    J Wound Care 16:129-32. 2007
    ..To evaluate the performance (efficacy and safety) of an absorbent dressing impregnated with silver salts (UrgoCell Silver) in the management of leg ulcers with clinical signs of critical colonisation...
  43. ncbi Electrospinning and biocompatibility evaluation of biodegradable polyurethanes based on L-lysine diisocyanate and L-lysine chain extender
    Jian Han
    School of Materials Science and Engineering, Beijing Institute of Technology, No 5 Zhongguancun South Street, Haidian District, Beijing 100081, China
    J Biomed Mater Res A 96:705-14. 2011
    A series of biodegradable polyurethanes (PUs) were synthesized using poly(ε-caprolactone) diol (PCL) to react with L-lysine ethyl ester diisocyanate (LDI) chain extend with L-lysine ethyl ester (LEE) in solution of DMF...
  44. ncbi Bio-based biodegradable and biocompatible hyperbranched polyurethane: a scaffold for tissue engineering
    Beauty Das
    Advanced Polymer and Nanomaterial Laboratory, Department of Chemical Sciences, Tezpur University, Tezpur 784028, India
    Macromol Biosci 13:126-39. 2013
    Hyperbranched polyurethanes are synthesized using TDI, PCL diol, butanediol, and pentaerythritol (1-5 wt%) as the B(4) reactant with and without the monoglyceride of sunflower oil...
  45. ncbi Catalyst-free synthesis of high elongation degradable polyurethanes containing varying ratios of isosorbide and polycaprolactone: physical properties and biocompatibility
    Hyung Seok Park
    Department of Nanobiomedical Science and WCU Research Center, Dankook University Graduate School, Chungnam, 330 714, South Korea
    J Mater Sci Mater Med 24:281-94. 2013
    Biocompatible and biodegradable polyurethanes were prepared with fixed aliphatic diisocyanate level and varying ratios of isosorbide, and PCL diol via a simple one-shot polymerization without a catalyst...
  46. ncbi Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
    Guang Yuh Chiou
    Institute of Pharmacology, National Yang Ming University, Taiwan
    J Control Release 159:240-50. 2012
    ..Our results demonstrated that miR145 acts as a switch regulating lung CSC-like and EMT properties, and provide insights into the clinical prospect of miR145-based therapies for malignant lung cancers...
  47. ncbi [Assessment of the mechanical properties and biocompatibility of a new electrospun polyurethane vascular prosthesis]
    Wei He
    Department of Vascular Surgery, Sun Yat Sen University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:2006-11. 2011
    ..To develop a small-caliber vascular grafts and study its morphologies, mechanical properties and biocompatibility...
  48. ncbi Photofunctional polyurethane nanofabrics doped by zinc tetraphenylporphyrin and zinc phthalocyanine photosensitizers
    Jiri Mosinger
    Faculty of Science, Charles University in Prague, Hlavova 2030, 128 40 Praha 2, Czech Republic
    J Fluoresc 19:705-13. 2009
    ..All nanofabrics have bactericidal surfaces and photooxidize inorganic and organic substrates. ZnTPP and ZnPc in the polyurethane nanofabrics are less photostable than incorporated free-base tetraphenylporphyrin (TPP)...
  49. ncbi In vitro fibroblast response to polyurethane organosilicate nanocomposites
    K E Styan
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia
    J Biomed Mater Res A 86:571-82. 2008
    ..The results of this study suggest that QAC may be unsuitable as organic modifiers for nanoparticles destined for biomedical use. Alternative modifiers based on AUA confer equivalent dispersion and are of low toxicity...
  50. ncbi Pore size, tissue ingrowth, and endothelialization of small-diameter microporous polyurethane vascular prostheses
    Ze Zhang
    Departement de Chirurgie, Faculte de Medecine, Université Laval Centre recherche de Hôpital Pavillon Saint François d Assise, CHUQ, 10, Rue de l Espinay, Local E0 165, Quebec QC, Canada G1V 3L5
    Biomaterials 25:177-87. 2004
    ..Expanded PTFE prostheses displayed smooth, thin intima, very limited tissue ingrowth, and incomplete coverage of endothelial-like cells...
  51. ncbi Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles
    Fernanda Crisante
    Department of Chemistry, Sapienza University of Rome P le A Moro 5, 00185 Rome, Italy
    Eur J Pharm Sci 36:555-64. 2009
    ..For these systems the drug delivery was at least of 50% with respect to nanoparticles alone with a prolonged antimicrobial activity up to 9 days...
  52. ncbi Physicochemical characterisation and biological evaluation of polyvinylpyrrolidone-iodine engineered polyurethane (Tecoflex(®))
    Anand P Khandwekar
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai, 600036, India
    J Mater Sci Mater Med 22:1231-46. 2011
    ..These results demonstrated that the PVP-I entrapment process can be applied on polyurethane in order to reduce/lower complications associated with bacterial adhesion and deposition of encrustation on polyurethanes.
  53. ncbi In vitro experiments and in vivo implants to evaluate a new silicone-based polyurethane material for replacement of small vessels
    Giorgio Soldani
    Laboratory for Biomaterials and Graft Technology, Institute of Clinical Physiology, CNR, Hospital G Pasquinucci, Massa, Italy
    Cardiol Young 14:20-3. 2004
  54. ncbi Fluorescent polyurethane nanofabrics: a source of singlet oxygen and oxygen sensing
    Jiri Mosinger
    Faculty of Science, Charles University in Prague, Hlavova 2030, 128 43 Praha 2, Czech Republic
    Langmuir 26:10050-6. 2010
    ..The integrated SODF achieved more than 20% of the prompt fluorescence for nanofabric loaded with 5 wt % TPP. The dependence of SODF intensity on the TPP concentration in nanofibers is nearly quadratic...
  55. ncbi Silicone based polyurethane materials: a promising biocompatible elastomeric formulation for cardiovascular applications
    E Briganti
    Laboratory for Biomaterials and Graft Technology, G Pasquinucci Hospital, Institute of Clinical Physiology CNR, Massa, Italy
    J Mater Sci Mater Med 17:259-66. 2006
    ..The achieved material shows properties similar to both polyurethanes and silicones. The material was transformed into porous membranes by a spray-deposition technique...
  56. ncbi TecoflexTM functionalization by curdlan and its effect on protein adsorption and bacterial and tissue cell adhesion
    Anand P Khandwekar
    Department of Biotechnology, Indian Institute of Technology Madras, Chennai, India
    J Mater Sci Mater Med 20:1115-29. 2009
    ..Using such simple surface entrapment process, it will be possible to develop well-defined surface modifications that promote specific cell interactions and perhaps better performance in the long-term as implant...
  57. ncbi Polyurethanes loaded with antibiotics: influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis
    A Piozzi
    Department of Chemistry, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    J Chemother 16:446-52. 2004
    Acidic or basic polyurethanes were loaded with antibiotics to develop materials to prevent medical device-related infections...
  58. ncbi Enzymatic degradation of poly(ether urethane) and poly(carbonate urethane) by cholesterol esterase
    Elizabeth M Christenson
    Center for Applied Polymer Research, Case Western Reserve University, Cleveland, OH 44106, USA
    Biomaterials 27:3920-6. 2006
    ..The oxidative H(2)O(2)/CoCl(2) treatment continues to accurately predict the long-term biostability of polyurethanes.
  59. ncbi Antimicrobial activity of polyurethanes coated with antibiotics: a new approach to the realization of medical devices exempt from microbial colonization
    A Piozzi
    Department of Chemistry, University La Sapienza, P le Aldo Moro, Rome 00185, Italy
    Int J Pharm 280:173-83. 2004
    ..In this paper, two antibiotics, rifampin and amoxicillin, have been adsorbed on polyurethanes exhibiting acidic or basic properties...
  60. ncbi Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivo
    Stanley J Stachelek
    Department of Pediatrics, The Children s Hospital of Philadelphia, Pennsylvania 19104 4318, USA
    Ann Thorac Surg 81:47-55. 2006
    ....
  61. ncbi Synthesis of two-component injectable polyurethanes for bone tissue engineering
    Ian C Bonzani
    Department of Materials, Imperial College London, London SW7 2AZ, UK
    Biomaterials 28:423-33. 2007
    ..Based on preliminary mechanical analysis and cytotoxicity results, these injectable polymers may have a number or potential orthopaedic applications; ranging from bone glues to scaffolds for bone regeneration...
  62. ncbi Bioactivity of polyurethane-based scaffolds coated with Bioglass
    M Bil
    Faculty of Materials Science and Engineering, Warsaw University of Technology, Woloska141, 02 507 Warsaw, Poland
    Biomed Mater 2:93-101. 2007
    ..PUR and PUR/PDLLA foams with Bioglass coating have potential to be used as bioactive, biodegradable scaffolds in bone tissue engineering...
  63. ncbi Porous bioactive scaffold of aliphatic polyurethane and hydroxyapatite for tissue regeneration
    Li Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu 610064, People s Republic of China
    Biomed Mater 4:025003. 2009
    ..The porous composite scaffold has good homogenization and a perfect three-dimensional structure for cell migration and bone tissue ingrowth, and should have good prospects for bone tissue regeneration...
  64. ncbi Nanocomposite containing bioactive peptides promote endothelialisation by circulating progenitor cells: an in vitro evaluation
    N Alobaid
    Academic Division of Surgical and Interventional Sciences, Biomaterials and Tissue Engineering Centre BTEC, University College London, Hampstead Campus, London NW3 2PF, UK
    Eur J Vasc Endovasc Surg 32:76-83. 2006
    ..We hypothesised that a novel approach to improve endothelialisation of bypass grafts by EPCs would be the creation on the graft lumen of a microenvironment that supports EPC adhesion and differentiation...
  65. ncbi The use of long-chain plant polyprenols as a means to modify the biological properties of new biodegradable polyurethane scaffolds for tissue engineering. A pilot study
    Krystyna Walinska
    Department of Biology, Institute of Biotechnology and Environmental Sciences, University of Zielona Gora, ul prof Z Szafrana 1, Zielona Gora 65 516, Poland
    J Mater Sci Mater Med 19:129-35. 2008
    ..Impregnation of polyurethane scaffolds with biologically active amphiphilic polyprenols may be a route to facilitate the cell-material interaction...
  66. ncbi The effect of provisional restoration type on micromovement of implants
    Stefan Holst
    Dental Clinic 2, Department of Prosthodontics, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Prosthet Dent 100:173-82. 2008
    ..The impact of acrylic resin or metal-reinforced acrylic resin provisional restorations on this movement is currently unknown...
  67. ncbi Platelet adhesion onto segmented polyurethane film surfaces modified by addition and crosslinking of PEO-containing block copolymers
    J H Lee
    Department of Polymer Science and Engineering, Hannam University, Daedeog Ku, Taejon, South Korea
    Biomaterials 21:683-91. 2000
    ....
  68. ncbi Hydroxyapatite-coated polyurethane for auricular cartilage replacement: an in vitro study
    Avashnee Chetty
    Council for Scientific and Industrial Research, Material Science and Manutacturing, PO Box 395, CSIR MSM, Polymers, Ceramics, and Composites, Pretoria, Gauteng, South Africa
    J Biomed Mater Res A 84:475-82. 2008
    ..This indicates that HA coated PU surfaces are cytocompatible towards fibroblasts and could potentially be applied to auricular cartilage tissue replacement...
  69. ncbi Biocompatibility of resin-modified filling materials
    W Geurtsen
    Department of Conservative Dentistry and Periodontology, Medical University Hannover, Germany
    Crit Rev Oral Biol Med 11:333-55. 2000
    ..Therefore, it is critical, both for our patients and for the profession, that the biological effects of resin-based filling materials be clarified in the near future...
  70. ncbi Long-term in vivo biostability of poly(dimethylsiloxane)/poly(hexamethylene oxide) mixed macrodiol-based polyurethane elastomers
    Anne Simmons
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney NSW 2052, Australia
    Biomaterials 25:4887-900. 2004
    ..Pellethane 80A, and as good as or better than both of the harder commercially available negative control polyurethanes, Pellethane 55D and Bionate 55D...
  71. ncbi Tissue engineered cartilage generated from human trachea using DegraPol scaffold
    Lin Yang
    Division of Thoracic Surgery, Laboratory of Tissue Engineering, University Hospital, Raemistrasse 100, CH 8091 Zurich, Switzerland
    Eur J Cardiothorac Surg 24:201-7. 2003
    ..In this study, we optimized isolation and cultivation techniques for human tracheal cartilage, assessing the feasibility of seeding these cells onto a novel, three-dimensional (3-D) polyester-urethane polymer (DegraPol)...
  72. ncbi Synthesis and characterization of non-leaching biocidal polyurethanes
    J A Grapski
    Department of Chemical Engineering, University of Delaware, Newark 19716, USA
    Biomaterials 22:2239-46. 2001
    The biocidal activities of a series of quaternized polyurethanes were examined against Staphylococcus aureus and Escherichia coli...
  73. ncbi In vivo resorption of a biodegradable polyurethane foam, based on 1,4-butanediisocyanate: a three-year subcutaneous implantation study
    B van Minnen
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Biomed Mater Res A 85:972-82. 2008
    Degradable polyurethanes (PUs), based on aliphatic diisocyanates, can be very useful in tissue regeneration applications. Their long-term in vivo degradation has not been extensively investigated...
  74. ncbi Analysis and evaluation of a biomedical polycarbonate urethane tested in an in vitro study and an ovine arthroplasty model. Part II: in vivo investigation
    Imran Khan
    Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, Cambridge CB2 3QZ, UK
    Biomaterials 26:633-43. 2005
    ..The findings in this study provide compelling evidence for the biostability and effectiveness of acetabular cups incorporating a Corethane 80A compliant bearing layer...
  75. ncbi Biological monitoring of aromatic diisocyanates in workers exposed to thermal degradation products of polyurethanes
    Christina Rosenberg
    Finnish Institute of Occupational Health, Helsinki
    J Environ Monit 4:711-6. 2002
    ..was assessed by biological monitoring among workers exposed to the thermal degradation products of polyurethanes (PURs) in five PUR-processing environments...
  76. ncbi Preparation, degradation, and calcification of biodegradable polyurethane foams for bone graft substitutes
    Katarzyna Gorna
    Polymer Research, AO ASIF Research Institute, Clavadelerstrasse, CH 7270 Davos, Switzerland
    J Biomed Mater Res A 67:813-27. 2003
    ..All polyurethane scaffolds induced the deposition of calcium phosphate crystals, the structure and calcium:phosphorus atomic ratio of which depended on the chemical composition of the polyurethane and varied from 1.52-2.0...
  77. ncbi Mechanical properties of small-diameter polyurethane vascular grafts reinforced by weft-knitted tubular fabric
    Weilin Xu
    Hubei New Textile and Its Application Key Laboratory, Wuhan University of Science and Engineering, Wuhan 430073, People s Republic of China
    J Biomed Mater Res A 92:1-8. 2010
    ..Microporous structure can also be fabricated in the wall of the reinforced composite vascular grafts...
  78. ncbi Assessment of PEO/PTMO multiblock copolymer/segmented polyurethane blends as coating materials for urinary catheters: in vitro bacterial adhesion and encrustation behavior
    Jae Hyung Park
    Department of Materials Science and Engineering, Center for Biomaterials and Biotechnology, Kwangju Institute of Science and Technology, South Korea
    Biomaterials 23:3991-4000. 2002
    ....
  79. ncbi Local delivery of tobramycin from injectable biodegradable polyurethane scaffolds
    Andrea E Hafeman
    Department of Chemical Engineering, 2301 Vanderbilt Place, VU Station B 351604, Vanderbilt University, Nashville, TN 37235, USA
    J Biomater Sci Polym Ed 21:95-112. 2010
    ..The versatility of the materials, as well as their potential for injection and controlled release, may present promising opportunities for new therapies for healing of infected wounds...
  80. ncbi Network structures and thermal properties of polyurethane films prepared from liquefied wood
    Y Kurimoto
    Institute of Wood Technology, Akita Prefectural University, Noshiro, Japan
    Bioresour Technol 77:33-40. 2001
    ..8 or with more than 10.6% dissolved wood started above 262 degrees C under an N2 atmosphere. The thermostability was lost at low crosslink density or with large amount of co-polymerized glycerol structures in the PU networks...
  81. ncbi A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors
    Enrica Briganti
    Laboratory for Biomaterials and Graft Technology, G Pasquinucci Hospital, Institute of Clinical Physiology, CNR, 54100Massa, Italy
    J Control Release 142:14-21. 2010
    ....
  82. ncbi Elastomeric biodegradable polyurethane blends for soft tissue applications
    J D Fromstein
    Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, Toronto, Ontario, Canada
    J Biomater Sci Polym Ed 13:391-406. 2002
    Four biodegradable polyurethane blends were made from segmented polyurethanes that contain amino acid-based chain extender and diisocyanate groups...
  83. ncbi Characterization of biodegradable polyurethane microfibers for tissue engineering
    Danielle N Rockwood
    Department of Materials Science and Engineering, University of Delaware, 201 DuPont Hall, Newark, DE 19716, USA
    J Biomater Sci Polym Ed 18:743-58. 2007
    ..It is believed that an electrospun matrix of this biodegradable polyurethane shows promise for use in soft tissue engineering and regenerative medicine applications...
  84. ncbi Microbial degradation of polyurethane, polyester polyurethanes and polyether polyurethanes
    T Nakajima-Kambe
    Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan
    Appl Microbiol Biotechnol 51:134-40. 1999
    ..Thus, PUR esterase and PHA depolymerase are probably different in terms of their evolutionary origin and it is possible that PUR esterases come to be classified as a new solid-polyester-degrading enzyme family...
  85. ncbi New prostheses for use in bypass grafts with special emphasis on polyurethanes
    Alok Tiwari
    Tissue Engineering Centre, University Department of Surgery, The Royal Free Hospital and Royal Free and University College Medical School, University College London, Pond Street, NW3 2QG, London, UK
    Cardiovasc Surg 10:191-7. 2002
    ..This review will focus on the lack of compliance in current vascular bypass grafts and the promise of the new polyurethane polymers in a new generation of small-bore bypass grafts...
  86. ncbi Biodegradable polyurethanes for implants. II. In vitro degradation and calcification of materials from poly(epsilon-caprolactone)-poly(ethylene oxide) diols and various chain extenders
    Katarzyna Gorna
    Polymer Research, AO ASIF Research Institute, CH 7270 Davos, Switzerland
    J Biomed Mater Res 60:592-606. 2002
    Linear, biodegradable, aliphatic polyurethanes with various degrees of hydrophilicity were synthesized in bulk at 50-100 degrees C...
  87. ncbi Electrospun aligned nanofibrous scaffold of carbon nanotubes-polyurethane composite for endothelial cells
    Zhaozhao Han
    Department of Biomedical Engineering, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P R China
    J Nanosci Nanotechnol 9:1400-2. 2009
    ..These results indicated the favorable interactions between ECs and the nanofibrous scaffold of MWNT/PU, implying that the aligned nanofibrous scaffold has a promising potential for vascular engineering...
  88. ncbi Biodegradation of lactic acid based polymers under controlled composting conditions and evaluation of the ecotoxicological impact
    Jukka Tuominen
    Department of Chemical Technology, Polymer Technology, Helsinki University of Technology, P O Box 6100, FIN 02150 HUT, Finland
    Biomacromolecules 3:445-55. 2002
    ..All other polymers, including poly(ester-urethane) chain linked with 1,4-butane diisocyanate, showed no toxicological effect...
  89. ncbi Catalyst-dependent drug loading of LDI-glycerol polyurethane foams leads to differing controlled release profiles
    Wesley N Sivak
    Department of Bioengineering, School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
    Acta Biomater 4:1263-74. 2008
    ..0x10(-8)). These results clearly demonstrate the long-term, catalyst-dependent release of DB-67 from LDI-glycerol polyurethane foams, indicating their potential for use in implantable drug-delivery devices...
  90. ncbi Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes
    Changhong Zhang
    Department of Bioengineering, Clemson University, Clemson, SC 29634, USA
    J Control Release 131:128-36. 2008
    ..The pH dependent properties were used to fabricate scaffolds by drop-on-demand printing. Bicine extended polyurethanes may be of interest for possible drug delivery applications, customizable scaffold fabrication and other ..
  91. ncbi Novel porous hydroxyapatite prepared by combining H2O2 foaming with PU sponge and modified with PLGA and bioactive glass
    Xiao Huang
    School of Materials Science and Engineering, Nanyang Technological University, Nanyang Avenue, 639798, Singapore
    J Biomater Appl 21:351-74. 2007
    ..The porous HA-based composites obtained from this study have suitable porous structures, proper mechanical properties, and a high bioactivity, and thus finds potential application as scaffolds for bone tissue engineering...
  92. ncbi Enhanced biocompatibility in biostable poly(carbonate)urethane
    Shan Hui Hsu
    Department of Chemical Engineering, National Chung Hsing University, Taichung, 402, Taiwan
    Macromol Biosci 4:464-70. 2004
    In this work, we synthesized two MDI-based polyurethanes, including a poly(ether)urethane (PEU) and a poly(carbonate)urethane (PCU), by using different soft segments, poly(tetramethylene oxide) and poly(hexyl, ethyl)carbonate diol (M ..
  93. ncbi A single center experience in the use of polyurethaneurea arteriovenous grafts
    Dijana Jefic
    Department of Nephrology and Hypertension, St John Hospital and Medical Center, Detroit, Michigan, USA
    Nephrol News Issues 19:44-7. 2005
    ..Polyurethaneurea (PUU) grafts can be cannulated within 24 hours of placement, avoiding the need for temporary catheters...
  94. ncbi Synthesis of biocompatible segmented polyurethanes from aliphatic diisocyanates and diurea diol chain extenders
    Scott A Guelcher
    Department of Biomedical Engineering, Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, PA 15213 3890, USA
    Acta Biomater 1:471-84. 2005
    ..However, many medical-grade polyurethanes are prepared from aromatic diisocyanates and can degrade in vivo to carcinogenic aromatic diamines, although ..
  95. ncbi Understanding the biodegradation of polyurethanes: from classical implants to tissue engineering materials
    J P Santerre
    Biomaterials Discipline, Faculty of Dentistry, University of Toronto, Toronto, Ont, Canada M5G 1G6
    Biomaterials 26:7457-70. 2005
    After almost half a century of use in the health field, polyurethanes (PUs) remain one of the most popular group of biomaterials applied for medical devices...
  96. pmc Preparation and characterization of highly porous, biodegradable polyurethane scaffolds for soft tissue applications
    Jianjun Guan
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Pittsburgh, PA 15219, USA
    Biomaterials 26:3961-71. 2005
    ..These biodegradable and flexible scaffolds demonstrate potential for future application as cell scaffolds in cardiovascular tissue engineering or other soft tissue applications...
  97. ncbi Multicenter evaluation of a polytetrafluoroethylene vascular access graft as compared with the expanded polytetrafluoroethylene vascular access graft in hemodialysis applications
    M H Glickman
    Virginia Vascular Associates, Norfolk 23502, USA
    J Vasc Surg 34:465-72; discussion 472-3. 2001
    ..Performance measures included graft survival, complications, time to early cannulation, and hemostasis times after cannulation...
  98. ncbi The biocompatibility and antibacterial properties of waterborne polyurethane-silver nanocomposites
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC
    Biomaterials 31:6796-808. 2010
    ..The dispersion of nano Ag was highly associated with the overall performance...
  99. ncbi Effect of the macromolecular architecture of biodegradable polyurethanes on the controlled delivery of ocular drugs
    Gisele Rodrigues da Silva
    School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil
    J Mater Sci Mater Med 20:481-7. 2009
    ..an important type of corticoid used in the treatment of some uveitis, was incorporated into biodegradable polyurethanes (PU) having different macromolecular architectures...
  100. ncbi In vitro degradation and erosion of degradable, segmented polyurethanes containing an amino acid-based chain extender
    G A Skarja
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada
    J Biomater Sci Polym Ed 12:851-73. 2001
    In vitro degradation and erosion of novel, degradable segmented polyurethanes containing a phenylalanine diester chain extender were investigated by exposing the polymers to buffer. chymotrypsin, and trypsin solutions for up to 28 days...
  101. ncbi Clinical and Doppler ultrasonography data of a polyurethane vascular access graft for haemodialysis: a prospective study
    Patrick Wiese
    Department of Nephrology, Klinikum Nuernberg, Germany
    Nephrol Dial Transplant 18:1397-400. 2003
    ..This study obtained new clinical and colour Doppler ultrasound (CDU) data of a polyurethane vascular access graft (PVAG) proposing early post-operative cannulation...

Research Grants60

  1. Biomedical Polymers With Heparin-Binding End Groups
    Robert Ward; Fiscal Year: 2004
    ..In Phase III The Polymer Technology Group will offer polyurethanes and device components with heparin binding capacity for sales or license, as part of its existing catalog of ..
  2. Thromboresistant Polymers via Catalytic Generation of NO
    Mark E Meyerhoff; Fiscal Year: 2012
    ..Our goals for Phase II will now focus on: 1) further synthesizing an array of biomedical grade polyurethanes (PUs) with covalently attached Cu(II)-cyclen complexes as catalytic sites, as well as preparing/evaluating PUs ..
  3. ELECTROSPINNING ARTIFICIAL LIGAMENTS AND TENDONS FOR POTENTIAL PROSTHESES
    JAVIER MACOSSAY-TORRES; Fiscal Year: 2011
    ..These studies will investigate the electrospinning conditions of biocompatible polyurethanes to obtain micro- and nanofibers, which will be assembled into specific secondary structures to resemble ..
  4. Continuous Biofilm Disrupting Materials
    SHANTHA SARANGAPANI; Fiscal Year: 2009
    ..vascular and other catheters and non-vascular stents are made of thermoplastic medical grade polymers such as polyurethanes. Additives such as colors, inert fillers etc are compounded with a resin under melt conditions, pelletized and ..
  5. COX-2 Mediated Vascular Toxicity of Methylenedianiline
    TAMMY DUGAS; Fiscal Year: 2003
    ..DAPM is a compound used in the production of polyurethanes, which are made into a plethora of products ranging from floor coverings to dialysis tubing and breast ..
  6. LONG TERM BIODEGRADATION OF ELASTOMERS MATERIALS
    P Hiltner; Fiscal Year: 2001
    The combination of outstanding chemical and physical properties of polyurethanes (PU's) coupled with their biocompatibility have led to their use in a wide range of biomedical applications...
  7. LONG TERM BIODEGRADATION OF ELASTOMERS MATERIALS
    P Hiltner; Fiscal Year: 2003
    The combination of outstanding chemical and physical properties of polyurethanes (PU's) coupled with their biocompatibility have led to their use in a wide range of biomedical applications...
  8. CELL AND PROTEIN REACTIONS WITH FOREIGN MATERIALS
    THOMAS HORBETT; Fiscal Year: 2001
    ..For certain polyurethanes (PEUs), important specific materials variables are thought to be the alkyl chain length and density and the ..
  9. INFLAMATION AND INFECTION ON BIOMATERIALS
    ERIC KALER; Fiscal Year: 2001
    ..adsorbed proteins on these interactions and how they are affected by the material surface will be examined on polyurethanes which contain pendant sulfanate, quaternary amine, alkyl, or phosphonate groups...
  10. A DICHOTOMOUS SAMPLER FOR TRIG AEROSOL AND VAPOR
    Roy Rando; Fiscal Year: 1993
    The isocyanates are an important class of commercial chemicals used in the production of polyurethanes and certain pesticides...
  11. INFECTION RESISTANT POLYURETHANE MATERIALS
    Michael Szycher; Fiscal Year: 1999
    ..The investigators seek to develop infection -- resistant polyurethanes using techniques from polymer chemistry, textile science and biomedical research...
  12. Antimicrobial Polymers for Medical Application
    HANS GLASER; Fiscal Year: 2002
    ..These antimicrobial dendrimers have also been successfully immobilized on to linear polyurethanes. These non-leaching biocidal polymers demonstrated antibacterial activity, even though the degree of ..
  13. DEVELOPMENT OF SYNTHETIC POLYURETHANE MATERIALS
    Michael Szycher; Fiscal Year: 1999
    ..Because of legal liability concerns, several manufacturers have withdrawn medical-grade polyurethanes from the implantables market. In addition, the exact composition of these polymers is largely unknown...
  14. BREATHABLE FILMS FOR PROPHYLAXIS & CONTAMINATION CONTROL
    Robert Ward; Fiscal Year: 1990
    ..Five homologous, amphipathic polyurethanes will be synthesized with increasing hydrophilic content, and used to cast elastomeric, pinhole-free films with ..
  15. POLYMER MODIFICATION VIA SURFACE-MODIFYING END GROUPS
    Robert Ward; Fiscal Year: 2000
    ..To date, the SME method has been used primarily with solution- processed segmented polyurethanes giving enhanced thromoboresistance, biostability and abrasion resistance in vitro and in vivo tests...
  16. IN-VIVO EVALUATION OF SURFACE-INDUCED THROMBOGENESIS
    Stuart Cooper; Fiscal Year: 1992
    ..will attempt to elucidate the pathways involved in the biodegradation of medical grade polymers and modified polyurethanes. These studies will lead to a better understanding of the mechanisms involved in artificial surface-induced ..
  17. BIOMEDICAL RESEARCH SUPPORT
    Donald Bers; Fiscal Year: 1991
    ..application include endothelial cell growth, protein adsorption, orthopaedic and dental implant corrosion, polyurethanes for artificial hearts and vascular grafts, cell-surface studies, platelet interactions with synthetic polymers,..
  18. Shape Memory Polymer Devices for Treating Stroke
    Duncan J Maitland; Fiscal Year: 2012
    ..developments during the first award period are the enabling cornerstones of the current proposal: novel SMP polyurethanes with improved thermomechanical, optical and biocompatibility properties;SMP foams;successful animal model and ..
  19. Polyurethane Biomaterials with Heparin Binding Sites
    Robert Ward; Fiscal Year: 2002
    ..Surfaces of the resulting PIME-containing polyurethanes will be characterized by Sum Frequency Generation Spectroscopy (SFG), Contact Angle Goniometry, and Atomic ..
  20. Assesment of a Chronic Subcutaneous Glucose Sensor
    W Ward; Fiscal Year: 2003
    ..The body can be hostile to compounds which coat implanted devices. We will compare two promising polyurethanes as sensor coats: a carbonate based- vs. ether-based polymer...
  21. High-Modulus Polyurethanes for Bone Tissue Engineering
    Aaron Goldstein; Fiscal Year: 2006
    ..b>Polyurethanes are a class of durable biocompatible polymers well suited for numerous biomedical applications...
  22. NANOTEXTURED POLYURETHANES FOR REDUCED PLATELET ADHESION
    CHRISTOPHER SIEDLECKI; Fiscal Year: 2006
    ..Furthermore, the use of 150 mm diameter silicon wafers as will produce nanotextured polymer films suitable for fabrication into diaphragms for use as the blood-contacting surface for use in circulatory support devices. ..
  23. THERMOPLASTIC SILOXANE-URETHANE COPOLYMER DEVELOPMENT
    Robert Ward; Fiscal Year: 1990
    This project would test the hypothesis that biostability of thermoplastic polyurethanes (TPU) can be improved by replacing all or part of the polyether soft segment with telechelic polydimethylsiloxane (PSX) oligomer during synthesis...
  24. METHYLENE DIANILINE TOXICITY TO BILIARY EPITHELIAL CELLS
    Vicente Santa Cruz; Fiscal Year: 2000
    ..dianiline (4,4'-diaminodiphenylmethane, DAPM) is a compound widely used in the production of epoxy resins and polyurethanes which are currently used to make items such as intra-aortic balloons and tubing of artificial dialysis ..
  25. POLYURETHANE-UREA PRIMARY REFERENCE MATERIALS
    Kathleen White; Fiscal Year: 1993
    b>Polyurethanes are used in a variety of biomedical devices including artificial hearts, vascular grafts, catheters, and intra-aortic balloons...
  26. TACTILE SENSORS FOR THE INSENSATE HAND
    John Webster; Fiscal Year: 1990
    ..8) Make the system available to physicians who treat patients with insensate hands. (9) Investigate alternative sensors such as capacitive, semiconductor strain gage, and optical sensors as a possible improvement...
  27. Polyurethane Calcification:Mechanism and Inhibition
    Robert Levy; Fiscal Year: 2004
    Polyurethane calcification and associated thrombosis remain major obstacles hindering the long term use of polyurethanes in prosthetic valves and ventricular assist systems...
  28. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2002
    ....
  29. Assessment of Tissue Response to Stress
    Joan Sanders; Fiscal Year: 2006
    ..this technology could be applied to other areas of rehabilitation, for example, shoe design for patients with insensate feet, cushion design for wheelchair users, and mattress design for bedridden patients [unreadable] [unreadable]..
  30. Skin Adaptation to Mechanical Stress
    Joan Sanders; Fiscal Year: 2006
    ..By understanding the process of skin adaptation (natural skin strengthening) at both a cellular and molecular level, therapies to encourage skin adaptation before breakdown occurs can be intelligently pursued. ..
  31. INTERFACE MECHANICS, MATERIALS AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2007
    ..The development of methods to predict and overcome the detrimental effects of residual limb shape change and ultimately prevent soft-tissue breakdown will help to prevent secondary disability and morbidity in the amputee population. ..
  32. INTERFACE MECHANICS, MATERIALS, AND TISSUE RESPONSE
    Joan Sanders; Fiscal Year: 2003
    ....
  33. NEW BIOMATERIALS TO MINIMIZE SCAR TISSUE FORMATION
    Joan Sanders; Fiscal Year: 2002
    ..e. soft-tissue complications that require surgical repair through use of a biomaterial. The new materials will prevent scar tissue formation and reduce the occurrence of secondary complications. ..
  34. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2007
    ....
  35. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
  36. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2001
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  37. CERAMIC WHISKER REINFORCEMENT OF DENTAL COMPOSITE RESINS
    HUAKUN XU; Fiscal Year: 2002
    ....
  38. BIOFUNCTIONAL MATERIALS CONTAINING PROTEIN MIMETICS
    WEIYUAN KAO; Fiscal Year: 2003
    ..The controlled release of these bioactive factors may have therapeutic values in the fundamental processes of inflammation, biocompatibility, and tissue healing. ..
  39. Interaction between host cells and multicomponent material matrix
    WEIYUAN KAO; Fiscal Year: 2009
    ..e., human blood-derived macrophages, dermal fibroblasts, and keratinocytes) using monoculture and binary cell culture systems. (3) To ascertain IPN efficacy in vivo in modulating the host reaction and healing. ..
  40. Isocyanate Exposure Intervention Study in Body Shops
    Youcheng Liu; Fiscal Year: 2004
    ..abstract_text> ..
  41. Minimally Invasive Surgical Therapies for BPH - Treatme*
    Robert Donnell; Fiscal Year: 2005
    ..In summary, this proposal outlines what we believe to be the outstanding credentials of the Division of Urology, the Medical College of Wisconsin to serve as a clinical center in this multi-institutional trial. ..
  42. New Serodiagnostics for Isocyanate Exposure, A Major Cause of Occupational Asthma
    ADAM WISNEWSKI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  43. CONTROLLED-RELEASE SEALANT TO PREVENT SECONDARY CARIES
    Kenneth Anusavice; Fiscal Year: 2004
    ..mutans, site specific levels of S. mutans at the margins of amalgam and composite restorations, and the width of marginal crevices adjacent to amalgam and composite restorations). ..
  44. Methyl Mercury Evaluation in Dental Waste Water
    James Drummond; Fiscal Year: 2003
    ..Hypothesis: Element mercury released in DWW is converted to Hg(lI) and then in more limited amounts to methyl-mercury by specific biofilm bacterial species in the Dental sewage pipes. ..
  45. Development of Gel Dosimeters for Radiotherapy
    John Adamovics; Fiscal Year: 2002
    ..Even though it is difficult to predict the annual number of conformal radiotherapies performed it is clearly growing in number. There are over 600,000 patients annually requiring radiation therapy in USA. ..
  46. Antiretroviral Therapy, Endothelial Dysfunction and Atherosclerosis
    Tammy R Dugas; Fiscal Year: 2010
    ..The proposed work will thus be of clinical benefit in devising ways in which to better treat HIV-infected individuals. ..
  47. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
  48. Regulation of Sodium Excretion in Knockout Mice
    John Lorenz; Fiscal Year: 2008
    ..abstract_text> ..
  49. Novel Nanostructured Dental Glass-Ionomers for Advanced Dental Restoratives
    Dong Xie; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  50. p38alpha and beta MAP Kinases in Endothelial Cells
    Yan Lin Guo; Fiscal Year: 2005
    ..This investigation may provide new knowledge to the development of novel therapeutic drugs for diseases associated with angiogenesis. ..
  51. Novel Amino Acid-Based Glass-Ionomer Biomaterials
    Dong Xie; Fiscal Year: 2005
    ..abstract_text> ..
  52. Isocyanate Antigens and T-cells that Cause Asthma
    ADAM WISNEWSKI; Fiscal Year: 2005
    ..Together the results should provide significant insights into the pathogenesis of diisocyanate asthma. ..
  53. Periodontal Disease and Prematurity
    Ananda Dasanayake; Fiscal Year: 2006
    ..The collective expertise of the investigative team and the excellent clinical and research facilities are additional strengths. ..
  54. Human Lung gamma/delta T cells, Antigens and Functions
    ADAM WISNEWSKI; Fiscal Year: 2004
    ..The results of these experiments should provide important insights into the role of airway mucosal gamma/delta T cells in maintaining human pulmonary immune homeostasis. ..
  55. NANOPOROUS INOGANIC BIOCAPSULES
    Tejal Desai; Fiscal Year: 2003
    ..abstract_text> ..
  56. P38alpha in Mouse Embryonic Stem Cells
    Yan Lin Guo; Fiscal Year: 2007
    ..The knowledge derived from this study could be valuable for the development of cell-based therapeutic approaches for diseases associated with angiogenesis and cardiovascular malfunction. [unreadable] [unreadable] [unreadable]..
  57. Physical Activity, Nutrition & Built Environment in a Bi-national Border Setting
    George King; Fiscal Year: 2006
    ..By identifying how the built environment may be contributing to intake and activity, the proposed research should lead to a better understanding of the causes of obesity and routes for prevention and treatment. ..