proanthocyanidins

Summary

Summary: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.

Top Publications

  1. ncbi Proanthocyanidins--a final frontier in flavonoid research?
    Richard A Dixon
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, Oklahoma 73401, USA
    New Phytol 165:9-28. 2005
  2. pmc Ectopic expression of VvMybPA2 promotes proanthocyanidin biosynthesis in grapevine and suggests additional targets in the pathway
    Nancy Terrier
    UMR SPO 1083, Campus SupAgro INRA, F 34060 Montpellier, France
    Plant Physiol 149:1028-41. 2009
  3. pmc Proanthocyanidins modulate microRNA expression in human HepG2 cells
    Anna Arola-Arnal
    Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 6:e25982. 2011
  4. pmc The grapevine transcription factor VvMYBPA1 regulates proanthocyanidin synthesis during fruit development
    Jochen Bogs
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Glen Osmond, 5064, Australia
    Plant Physiol 143:1347-61. 2007
  5. pmc Proanthocyanidin synthesis and expression of genes encoding leucoanthocyanidin reductase and anthocyanidin reductase in developing grape berries and grapevine leaves
    Jochen Bogs
    Commonwealth Scientific and Industrial Research Organization, Plant Industry, Horticulture Unit, Glen Osmond, South Australia
    Plant Physiol 139:652-63. 2005
  6. ncbi MALDI-TOF MS analysis of plant proanthocyanidins
    Maria Monagas
    Instituto de Fermentaciones Industriales CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Pharm Biomed Anal 51:358-72. 2010
  7. ncbi Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    De Yu Xie
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Science 299:396-9. 2003
  8. pmc MATE transporters facilitate vacuolar uptake of epicatechin 3'-O-glucoside for proanthocyanidin biosynthesis in Medicago truncatula and Arabidopsis
    Jian Zhao
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 21:2323-40. 2009
  9. ncbi Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis
    Yan Hong Wang
    Department of Pharmacy, People s Hospital of Gansu Province, Lanzhou 730000, Gansu, China
    Int Immunopharmacol 11:1620-7. 2011
  10. ncbi Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
    D Bagchi
    Department of Pharmaceutical and Administrative Sciences, Creighton University School of Pharmacy and Allied Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
    Toxicology 148:187-97. 2000

Detail Information

Publications291 found, 100 shown here

  1. ncbi Proanthocyanidins--a final frontier in flavonoid research?
    Richard A Dixon
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, Oklahoma 73401, USA
    New Phytol 165:9-28. 2005
    b>Proanthocyanidins are oligomeric and polymeric end products of the flavonoid biosynthetic pathway. They are present in the fruits, bark, leaves and seeds of many plants, where they provide protection against predation...
  2. pmc Ectopic expression of VvMybPA2 promotes proanthocyanidin biosynthesis in grapevine and suggests additional targets in the pathway
    Nancy Terrier
    UMR SPO 1083, Campus SupAgro INRA, F 34060 Montpellier, France
    Plant Physiol 149:1028-41. 2009
    Grapevine (Vitis vinifera) proanthocyanidins contribute to plant defense mechanisms against biotic stress and also play a critical role in organoleptic properties of wine...
  3. pmc Proanthocyanidins modulate microRNA expression in human HepG2 cells
    Anna Arola-Arnal
    Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain
    PLoS ONE 6:e25982. 2011
    ..b>Proanthocyanidins, which are the most abundant polyphenol class in the human diet, have positive health effects on a variety ..
  4. pmc The grapevine transcription factor VvMYBPA1 regulates proanthocyanidin synthesis during fruit development
    Jochen Bogs
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Glen Osmond, 5064, Australia
    Plant Physiol 143:1347-61. 2007
    b>Proanthocyanidins (PAs; or condensed tannins) can protect plants against herbivores, contribute to the taste of many fruits, and act as dietary antioxidants beneficial for human health...
  5. pmc Proanthocyanidin synthesis and expression of genes encoding leucoanthocyanidin reductase and anthocyanidin reductase in developing grape berries and grapevine leaves
    Jochen Bogs
    Commonwealth Scientific and Industrial Research Organization, Plant Industry, Horticulture Unit, Glen Osmond, South Australia
    Plant Physiol 139:652-63. 2005
    b>Proanthocyanidins (PAs), also called condensed tannins, can protect plants against herbivores and are important quality components of many fruits...
  6. ncbi MALDI-TOF MS analysis of plant proanthocyanidins
    Maria Monagas
    Instituto de Fermentaciones Industriales CSIC, Juan de la Cierva 3, 28006 Madrid, Spain
    J Pharm Biomed Anal 51:358-72. 2010
    b>Proanthocyanidins or condensed tannins are among the most abundant polyphenols compounds in our diet and may play a key role in the prevention of cardiovascular and neurodegenerative diseases and cancer...
  7. ncbi Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis
    De Yu Xie
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Science 299:396-9. 2003
    ..Ectopic expression of BAN in tobacco flower petals and Arabidopsis leaves results in loss of anthocyanins and accumulation of CTs...
  8. pmc MATE transporters facilitate vacuolar uptake of epicatechin 3'-O-glucoside for proanthocyanidin biosynthesis in Medicago truncatula and Arabidopsis
    Jian Zhao
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 21:2323-40. 2009
    ..membrane vesicles when expressed in yeast, there is no evidence that cyanidin 3-O-glucoside is converted to proanthocyanidins after transport into the vacuole...
  9. ncbi Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis
    Yan Hong Wang
    Department of Pharmacy, People s Hospital of Gansu Province, Lanzhou 730000, Gansu, China
    Int Immunopharmacol 11:1620-7. 2011
    The aim of this study was to elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE) on recurrent ulcerative colitis (UC) in rats...
  10. ncbi Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
    D Bagchi
    Department of Pharmaceutical and Administrative Sciences, Creighton University School of Pharmacy and Allied Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
    Toxicology 148:187-97. 2000
    ..Oligomeric proanthocyanidins, naturally occurring antioxidants widely available in fruits, vegetables, nuts, seeds, flowers and bark, ..
  11. pmc Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress
    Sabry M Attia
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 3:404-13. 2010
    This study has been initiated to determine whether proanthocyanidins can protect against doxorubicin-induced mutagenicity in mice and to elucidate the potential mechanism of this protection...
  12. pmc Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo
    H Koo
    Eastman Department of Dentistry, University of Rochester Medical Center, Rochester, NY 14620, USA hyun_koo urmc rochester edu
    Caries Res 44:116-26. 2010
    ..The presence of proanthocyanidins (PAC) in cranberry extracts has been linked to biological activities against specific virulence attributes ..
  13. ncbi The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro
    L Y Foo
    Blueberry Cranberry Research Center, Rutgers University, Chatswortli, NJ 08019, USA
    Phytochemistry 54:173-81. 2000
    Ethyl acetate extracts of Sephadex LH20-purified proanthocyanidins of American cranberry (Vaccinium macrocarpon Ait...
  14. ncbi Bioactive compounds in cranberries and their role in prevention of urinary tract infections
    Amy B Howell
    Marucci Center or Blueberry and Cranberry Research and Extension, Rutgers, The State University of New Jersey, Chatsworth, NJ 08019, USA
    Mol Nutr Food Res 51:732-7. 2007
    ..However, recently, a group of proanthocyanidins (PACs) with A-type linkages were isolated from cranberry which exhibit bacterial antiadhesion activity ..
  15. ncbi Proanthocyanidin biosynthesis in plants. Purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA
    Gregory J Tanner
    CSIRO Plant Industry, GPO Box 1600, Canberra, Australian Capital Territory 2601, Australia
    J Biol Chem 278:31647-56. 2003
    ..This may be because Arabidopsis seems to produce only an epicatechin, rather than a dual catechin/epicatechin-based PA similar to many other plants...
  16. ncbi Metabolism of dietary procyanidins in rats
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, Saint Genes Champanelle, France
    Free Radic Biol Med 35:837-44. 2003
    ..This will have to be considered to explain the health effects of procyanidins. The contribution of their microbial metabolites should also be further investigated...
  17. ncbi Occurrence and biological significance of proanthocyanidins in the American diet
    Ronald L Prior
    US Department of Agriculture, Agricultural Research Service, Arkansas Children s Nutrition Center, 1120 Marshall St, Little Rock, AR 72202, USA
    Phytochemistry 66:2264-80. 2005
    Dietary intake of proanthocyanidins (PAs) has been largely unknown because of the lack of reliable values for their content in foods...
  18. ncbi The strawberry transcription factor FaMYB1 inhibits the biosynthesis of proanthocyanidins in Lotus corniculatus leaves
    Francesco Paolocci
    National Research Council, Plant Genetics Institute Perugia, Perugia Division, Via Madonna Alta 130, 06128 Perugia, Italy
    J Exp Bot 62:1189-200. 2011
    b>Proanthocyanidins (PAs) are agronomically important biopolymers in higher plants composed primarily of catechin and epicatechin units...
  19. pmc Grape seed proanthocyanidins reactivate silenced tumor suppressor genes in human skin cancer cells by targeting epigenetic regulators
    Mudit Vaid
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Toxicol Appl Pharmacol 263:122-30. 2012
    Grape seed proanthocyanidins (GSPs) have been shown to have anti-skin carcinogenic effects in in vitro and in vivo models. However, the precise epigenetic molecular mechanisms remain unexplored...
  20. pmc Early steps in proanthocyanidin biosynthesis in the model legume Medicago truncatula
    Yongzhen Pang
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Physiol 145:601-15. 2007
    Oligomeric proanthocyanidins (PAs) composed primarily of epicatechin units accumulate in the seed coats of the model legume Medicago truncatula, reaching maximal levels at around 20 d after pollination...
  21. ncbi Proanthocyanidins in health care: current and new trends
    P Cos
    Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    Curr Med Chem 11:1345-59. 2004
    ..An important but often overlooked group of polyphenols is that of the proanthocyanidins. Therefore, the present review is focused mainly on the antioxidant activity of proanthocyanidins and its ..
  22. pmc Multi-targeted prevention and therapy of cancer by proanthocyanidins
    Vijayalakshmi Nandakumar
    Department of Dermatology, University of Alabama at Birmingham, 1670, University Boulevard, Volker Hall 557, PO Box 202, Birmingham, AL 35294, USA
    Cancer Lett 269:378-87. 2008
    ..b>Proanthocyanidins are considered as one of them, and are abundantly available in various parts of the plants, such as fruits, ..
  23. pmc Grape proanthocyanidins induce apoptosis by loss of mitochondrial membrane potential of human non-small cell lung cancer cells in vitro and in vivo
    Tripti Singh
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e27444. 2011
    ..Here, we report that grape seed proanthocyanidins (GSPs) induce apoptosis of NSCLC cells, A549 and H1299, in vitro which is mediated through increased ..
  24. ncbi Dietary feeding of proanthocyanidins from grape seeds prevents photocarcinogenesis in SKH-1 hairless mice: relationship to decreased fat and lipid peroxidation
    Anshu Mittal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Carcinogenesis 24:1379-88. 2003
    ..Dietary feeding of proanthocyanidins extracted from grape seeds (GSP) (0.2 and 0...
  25. ncbi Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice
    Som D Sharma
    Department of Dermatology, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Mol Cancer Ther 6:995-1005. 2007
    We have shown previously that dietary grape seed proanthocyanidins (GSP) inhibit UVB-induced photocarcinogenesis in mice...
  26. ncbi Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B
    Praveen K Vayalil
    Department of Dermatology, University of Alabama at Birmingham, 35294, USA
    Carcinogenesis 25:987-95. 2004
    ..of our efforts to develop newer and effective chemopreventive agents for PCA, we evaluated the effect of proanthocyanidins from grape seeds (GSP) on metastasis-specific MMP-2 and -9 in human prostate carcinoma DU145 cells by ..
  27. ncbi Dietary grape seed proanthocyanidins inhibit 12-O-tetradecanoyl phorbol-13-acetate-caused skin tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated mouse skin, which is associated with the inhibition of inflammatory responses
    Syed M Meeran
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Carcinogenesis 30:520-8. 2009
    Grape seed proanthocyanidins (GSPs) possess anticarcinogenic activities...
  28. ncbi Flavan-3-ols: nature, occurrence and biological activity
    Patricia M Aron
    Department of Food Science and Technology, Oregon State University, Corvallis, OR, USA
    Mol Nutr Food Res 52:79-104. 2008
    ..flavonoid consumed in the American diet, the flavan-3-ols and their polymeric condensation products, the proanthocyanidins, are regarded as functional ingredients in various beverages, whole and processed foods, herbal remedies and ..
  29. ncbi Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana
    Jean Marc Routaboul
    Laboratoire de Biologie des Semences, UMR 204 INRA INAPG, Institut Jean Pierre Bourgin, 78026 Versailles Cedex, France
    Planta 224:96-107. 2006
    ..In addition, they also revealed the presence of new products in seed and underlined the plasticity of this metabolic pathway in the mutants...
  30. ncbi Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet
    Ximena Terra
    Department of Biochemistry and Biotechnology, Unitat d Enologia del Centre de Referencia en Tecnologia dels Aliments de la Generalitat de Catalunya, Universitat Rovira i Virgili, Tarragona, Spain
    J Nutr Biochem 20:210-8. 2009
    ....
  31. pmc DkMyb4 is a Myb transcription factor involved in proanthocyanidin biosynthesis in persimmon fruit
    Takashi Akagi
    Laboratory of Pomology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Plant Physiol 151:2028-45. 2009
    b>Proanthocyanidins (PAs) are secondary metabolites that contribute to the protection of the plant and also to the taste of the fruit, mainly through astringency...
  32. ncbi Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells
    S Deprez
    Laboratoire de Chimie Biologique, INRA, Institut National Agronomique Paris-Grignon (INA-PG, Thiverval-Grignon, France
    Antioxid Redox Signal 3:957-67. 2001
    The gut absorption of proanthocyanidins (PAs) and of the related (+)-catechin monomer was investigated with colonic carcinoma (Caco-2) cells of a human origin, grown in monolayers on permeable filters...
  33. ncbi Proanthocyanidin biosynthesis--still more questions than answers?
    De Yu Xie
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Phytochemistry 66:2127-44. 2005
    b>Proanthocyanidins, also known as condensed tannins, are oligomers or polymers of flavan-3-ol units...
  34. pmc Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet
    Isabel Baiges
    Biochemistry and Biotechnology Department, Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Mol Cell Proteomics 9:1499-513. 2010
    Bioactive proanthocyanidins have been reported to have several beneficial effects on health in relation to metabolic syndrome, type 2 diabetes, and cardiovascular disease...
  35. ncbi Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis
    Mi La Cho
    The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea
    Immunol Lett 124:102-10. 2009
    ..These results indicate that intraperitoneal injection of GSPE attenuated CIA in mice. GSPE may be useful in the treatment of rheumatoid arthritis...
  36. ncbi The promoter of the Arabidopsis thaliana BAN gene is active in proanthocyanidin-accumulating cells of the Brassica napus seed coat
    Nathalie Nesi
    UMR118 INRA Agrocampus Ouest Université de Rennes1 Amélioration des Plantes et Biotechnologies Végétales, Le Rheu Cedex, France
    Plant Cell Rep 28:601-17. 2009
    ....
  37. ncbi A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota
    Stavroula Stoupi
    Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK
    Mol Nutr Food Res 54:747-59. 2010
    ..It was confirmed that catabolism favoured removal of the 4'-hydroxyl rather than the 3'-hydroxyl group and that both beta-oxidation and alpha-oxidation occurred...
  38. ncbi Effects of Areca catechu L. containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo
    Pei Ling Huang
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Food Chem Toxicol 48:306-13. 2010
    ..In conclusion, ANE, which contains catechins based oligomeric and polymeric procyanidins, regulates COX-2 expression in vitro and possess anti-inflammatory potential in vivo...
  39. pmc Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc
    Heather Ray
    Saskatoon Research Centre, Agriculture and Agri Food Canada, 107 Science Place, Saskatoon, Saskatchewan, Canada S7N 0X2
    Plant Physiol 132:1448-63. 2003
    ..These results demonstrate that proanthocyanidin biosynthesis can be stimulated in alfalfa forage using an myc-like transgene, and they pave the way for the development of high quality, bloat-safe cultivars with ruminal protein bypass...
  40. ncbi Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver
    H Quesada
    Departament de Bioquimica i Biotecnologia, Nutrigenomics Research Group, Universitat Rovira i Virgili, Tarragona, Spain
    Int J Obes (Lond) 33:1007-12. 2009
    To determine whether proanthocyanidins can protect against dyslipidemia induced by a high-fat diet (HFD) and to address the mechanisms that underlie this hypolipidemic effect.
  41. ncbi Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children
    Martin Gotteland
    Laboratory of Microbiology and Probiotics, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile
    Nutrition 24:421-6. 2008
    ..have been shown to inhibit Helicobacter pylori in vitro owing to bacteriocin production and high levels of proanthocyanidins, respectively. These effects have been confirmed in clinical trials with H. pylori-positive subjects...
  42. ncbi Liquid chromatographic/electrospray ionization mass spectrometric studies of proanthocyanidins in foods
    Liwei Gu
    Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
    J Mass Spectrom 38:1272-80. 2003
    The proanthocyanidins in three foods (pinto beans, plums and cinnamon) were studied with electrospray ionization (ESI) mass spectrometry (MS) in the negative mode following separation by normal-phase high-performance liquid ..
  43. ncbi Intake estimation of total and individual flavan-3-ols, proanthocyanidins and theaflavins, their food sources and determinants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
    Viktoria Knaze
    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology ICO IDIBELL, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Br J Nutr 108:1095-108. 2012
    ..Flavan-3-ol, PA and theaflavin intakes were significantly different among all assessed groups. This study showed heterogeneity in flavan-3-ol, PA and theaflavin intake throughout the EPIC countries...
  44. ncbi Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Nutrition 23:351-5. 2007
    ..The present study examined whether dietary supplementation with cacao liquor proanthocyanidins (CLPr) could prevent elevation of blood glucose levels in mice with diabetes mellitus and obesity.
  45. ncbi Grape seed proanthocyanidins repress the hepatic lipid regulators miR-33 and miR-122 in rats
    Laura Baselga-Escudero
    Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, Tarragona, Spain
    Mol Nutr Food Res 56:1636-46. 2012
    ..Previous studies from our group have shown that proanthocyanidins, which are the most abundant polyphenols in the human diet, regulate lipid metabolism and are potent ..
  46. ncbi Cotton flavonoid structural genes related to the pigmentation in brown fibers
    Yue Hua Xiao
    Key Laboratory of Biotechnology and Crop Quality Improvement of the Ministry of Agriculture, PR China
    Biochem Biophys Res Commun 358:73-8. 2007
    ..staining demonstrated that high transcript levels of these genes in developing fibers and presence of proanthocyanidins in mature fibers co-segregated with brown fiber in a recombination inbred line population...
  47. pmc The swarming motility of Pseudomonas aeruginosa is blocked by cranberry proanthocyanidins and other tannin-containing materials
    Che O'May
    Department of Chemical Engineering, McGill University, 3610 University Street, Montreal, Quebec H3A 2B2, Canada
    Appl Environ Microbiol 77:3061-7. 2011
    ..Derivatives of cranberry fruit, predominantly condensed tannins called proanthocyanidins (PACs) have been reported to interfere with bacterial adhesion, but the effects of PACs and other tannins on ..
  48. ncbi Estimation of daily proanthocyanidin intake and major food sources in the U.S. diet
    Ying Wang
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 141:447-52. 2011
    b>Proanthocyanidins (PA), the polymers of flavan-3-ols, have cardioprotective and cancer preventive properties as shown in clinical studies. The PA intake in a free-living population has not yet been reported, however...
  49. ncbi TRANSPARENT TESTA 19 is involved in the accumulation of both anthocyanins and proanthocyanidins in Arabidopsis
    Satoshi Kitamura
    Department of Ion Beam Applied Biology, Japan Atomic Energy Research Institute, 1233 Watanuki machi, Takasaki, Gunma 370 1292, Japan
    Plant J 37:104-14. 2004
    Flavonoid compounds such as anthocyanins and proanthocyanidins (PAs; so-called condensed tannins) have a multitude of functions in plants...
  50. ncbi Vasodilating procyanidins derived from grape seeds
    David F Fitzpatrick
    Department of Pharmacology, College of Medicine, University of South Florida, Tampa, Florida 33612 4799, USA
    Ann N Y Acad Sci 957:78-89. 2002
    ..These EDR-active compounds (many of which also possess antioxidant activity), individually or in the form of wines, juices, or nutritional supplements, may be useful in preventing or treating cardiovascular diseases...
  51. ncbi Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products
    Qian Cai
    Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi Lu Hospital of Shandong University, China
    Biosci Biotechnol Biochem 75:1692-7. 2011
    ..GSPB2 may therefore have therapeutic potential in preventing and treating vascular complications of diabetes mellitus...
  52. ncbi Analysis of proanthocyanidin cleavage products following acid-catalysis in the presence of excess phloroglucinol
    J A Kennedy
    Department of Horticulture, Viticulture and Oenology, University of Adelaide, Waite Campus, PMB 1, Glen Osmond, South Australia 5064, Australia
    J Agric Food Chem 49:1740-6. 2001
    ..This procedure was used to investigate the composition of proanthocyanidins isolated from the seed and skin tissue of Vitis vinifera L. berries...
  53. ncbi The effect of supplementation of grape seed proanthocyanidin extract on vascular dysfunction in experimental diabetes
    Nilsel Okudan
    Department of Physiology, Selcuk University, Konya, Turkey
    J Med Food 14:1298-302. 2011
    ..Thus supplementation of GSPE may attenuate oxidative stress through the inhibition of lipid peroxidation and may restore endothelial function and reduce the risk of vascular disease in diabetes...
  54. ncbi A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli
    L Y Foo
    Industrial Research, Gracefield Research Center, PO Box 31 310, Lower Hutt, New Zealand
    J Nat Prod 63:1225-8. 2000
    ....
  55. ncbi Proteomics approach to study the mechanism of action of grape seed proanthocyanidin extracts on arterial remodeling in diabetic rats
    Xiao Li Li
    Department of Geriatrics, Qi Lu Hospital of Shandong University, Jinan, Shandong Province 250012, PR China
    Int J Mol Med 25:237-48. 2010
    ..Our findings might help to better understand the mechanism of diabetic macrovascular complications and provide novel targets for evaluating the effects of GSPE therapy...
  56. ncbi Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats
    Seigo Baba
    Nutritional Science Center, Health Laboratory, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama, Japan
    Free Radic Biol Med 33:142-8. 2002
    ..Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions...
  57. pmc Dietary procyanidins enhance transcriptional activity of bile acid-activated FXR in vitro and reduce triglyceridemia in vivo in a FXR-dependent manner
    Josep Maria Del Bas
    Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Campus Sescelades, Tarragona, Spain
    Mol Nutr Food Res 53:805-14. 2009
    ..This study adds dietary procyanidins to the arsenal of FXR ligands with potential therapeutic use to combat hypertriglyceridemia, type 2 diabetes and metabolic syndrome...
  58. ncbi Fractionation of polymeric procyanidins from lowbush blueberry and quantification of procyanidins in selected foods with an optimized normal-phase HPLC-MS fluorescent detection method
    Liwei Gu
    Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 50:4852-60. 2002
    ....
  59. ncbi Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms
    Cinta Bladé
    Nutrigenomics Group, Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain
    Mol Nutr Food Res 54:37-59. 2010
    b>Proanthocyanidins are the most abundant polyphenols in human diets. Epidemiological studies strongly suggest that proanthocyanidins protect against cardiovascular diseases...
  60. pmc Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study
    Amy B Howell
    Institut National de la Sante et de la Recherche Medicale, Espri26, Universite Montpellier 1, Nimes, France
    BMC Infect Dis 10:94. 2010
    ..has traditionally been utilized for prevention of urinary tract infections. The proanthocyanidins (PACs) in cranberry, in particular the A-type linkages have been implicated as important inhibitors of ..
  61. ncbi Cocoa procyanidins are stable during gastric transit in humans
    Laurent Y Rios
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    Am J Clin Nutr 76:1106-10. 2002
    ..Degradation of procyanidins under simulated gastric conditions at pH 2.0 has been reported in vitro...
  62. ncbi Cardioprotective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats
    K Karthikeyan
    Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India
    Int J Cardiol 115:326-33. 2007
    To investigate whether grape seed proanthocyanidins (GSP) might protect the heart against myocardial injury (MI) induced by isoproterenol (ISO), in a rat model.
  63. ncbi Ameliorative effects of lotus seedpod proanthocyanidins on cognitive deficits and oxidative damage in senescence-accelerated mice
    Yushi Gong
    Natural Product Laboratory, Department of Food Science and Technology, Huazhong Agriculture University, Wuhan 430070, People s Republic of China
    Behav Brain Res 194:100-7. 2008
    We investigated the effects of lotus seedpod proanthocyanidins (LSPC) administration by oral gavage for 3 months on body weight, learning and memory deficits using Y-maze test, oxidative stress and antioxidative enzyme activity in brain ..
  64. ncbi Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats
    Josep Maria Del Bas
    Departament de Bioquímica i Biotecnologia CeRTA Universitat Rovira i Virgili, Tarragona, Spain
    FASEB J 19:479-81. 2005
    ..These results could explain, at least in part, the beneficial long-term effects associated with moderate red wine consumption...
  65. ncbi Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials
    Okezie I Aruoma
    Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London SE1 0AA, UK
    Biofactors 27:245-65. 2006
    ..It is an optimized phenolic product containing catechin-type monomers and oligomeric proanthocyanidins, the easily absorbed forms...
  66. ncbi Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases
    Catherine C Neto
    Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth, North Dartmouth, MA 02747, USA
    Mol Nutr Food Res 51:652-64. 2007
    ..that could contribute to these protective effects, including flavonoids such as anthocyanins, flavonols, and proanthocyanidins; substituted cinnamic acids and stilbenes; and triterpenoids such as ursolic acid and its esters...
  67. ncbi Procyanidin dimers are metabolized by human microbiota with 2-(3,4-dihydroxyphenyl)acetic acid and 5-(3,4-dihydroxyphenyl)-gamma-valerolactone as the major metabolites
    Maaike M Appeldoorn
    Laboratory of Food Chemistry, Wageningen University, Wageningen, The Netherlands
    J Agric Food Chem 57:1084-92. 2009
    ..Metabolites that could be quantified accounted for at least 12 mol % of the dimers, assuming 1 mol of dimers is converted into 2 mol of metabolite. A degradation pathway, partly different from that of monomeric flavan-3-ols, is proposed...
  68. ncbi Water deficits accelerate ripening and induce changes in gene expression regulating flavonoid biosynthesis in grape berries
    Simone D Castellarin
    Dipartimento di Scienze Agrarie e Ambientali, University of Udine, Udine, Italy
    Planta 227:101-12. 2007
    ..These results demonstrate that manipulation of abiotic stress through applied water deficits not only modulates compositional changes during berry ripening, but also alters the timing of particular aspects of the ripening process...
  69. ncbi New perspectives on proanthocyanidin biochemistry and molecular regulation
    M A Susan Marles
    Saskatoon Research Centre, Agriculture and Agri Food Canada, 107 Science Place, Saskatoon, Saskatchewan S7N 0X2, Canada
    Phytochemistry 64:367-83. 2003
    ..These advances may now lead to a detailed understanding of how PA synthesis is controlled and to useful alterations in proanthocyanidin concentration for the improvement of forage species, pulses, and other crop plants...
  70. ncbi Characterization of major enzymes and genes involved in flavonoid and proanthocyanidin biosynthesis during fruit development in strawberry (Fragaria xananassa)
    João R M Almeida
    ENEA, Trisaia Research Center, Department of Genetics and Genomics, S S 106, km 419 500, 75026 Rotondella, MT, Italy
    Arch Biochem Biophys 465:61-71. 2007
    The biosynthesis of flavonoids and proanthocyanidins was studied in cultivated strawberry (Fragaria xananassa) by combining biochemical and molecular approaches...
  71. ncbi Grape seed proanthocyanidins inhibit UV-radiation-induced oxidative stress and activation of MAPK and NF-kappaB signaling in human epidermal keratinocytes
    Sudheer K Mantena
    Department of Dermatology, University of Alabama at Birmingham, Volker Hall 557, 1670 University Boulevard, P O Box 202, Birmingham, AL 35294, USA
    Free Radic Biol Med 40:1603-14. 2006
    ..Here, we report the photoprotective effect of grape seed proanthocyanidins (GSPs) on UV-induced oxidative stress and activation of mitogen-activated protein kinase (MAPK) and NF-..
  72. ncbi Cranberries (Vaccinium macrocarpon) and cardiovascular disease risk factors
    Diane L McKay
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachussetts 02111, USA
    Nutr Rev 65:490-502. 2007
    ..Research regarding the bioactivity of cranberries and their constituents on risk factors for CVD is reviewed...
  73. ncbi The transcriptional response of hybrid poplar (Populus trichocarpa x P. deltoides) to infection by Melampsora medusae leaf rust involves induction of flavonoid pathway genes leading to the accumulation of proanthocyanidins
    Manoela Miranda
    Centre for Forest Biology and Department of Biology, University of Victoria, Victoria, BC, Canada
    Mol Plant Microbe Interact 20:816-31. 2007
    ..medusae infection. In this highly compatible plant-pathogen interaction, we postulate that the biotrophic pathogen evades detection and suppresses early host responses...
  74. pmc Dissecting functions of KATANIN and WRINKLED1 in cotton fiber development by virus-induced gene silencing
    Jing Qu
    Temasek Life Sciences Laboratory, National University of Singapore, 117604 Singapore
    Plant Physiol 160:738-48. 2012
    ..Our results provide evidence that the TRV-VIGS system can be used for rapid functional analysis of genes involved in cotton fiber development...
  75. ncbi Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health
    Christian G Krueger
    Complete Phytochemical Solutions, LLC, Cambridge, WI 52523, USA
    Anal Bioanal Chem 405:4385-95. 2013
    The "A-type" proanthocyanidins in cranberry fruit (Vaccinium macrocarpon Ait.) are bioactive components associated with prevention of urinary tract infections (UTI)...
  76. ncbi Analyzing cranberry bioactive compounds
    J Cote
    INRS Institut Armand Frappier, Research Laboratory in Sciences Applied to Food, 531 des Prairies, Laval, Quebec, Canada H7V 1B7
    Crit Rev Food Sci Nutr 50:872-88. 2010
    ..responsible for its brilliant red color, and other secondary plant metabolites (flavonols, flavan-3-ols, proanthocyanidins, and phenolic acid derivatives)...
  77. ncbi Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy
    M Rossi
    Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Ann Oncol 23:1488-93. 2012
    ..Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results...
  78. ncbi Lingonberry (Vaccinium vitis-idaea) and European cranberry (Vaccinium microcarpon) proanthocyanidins: isolation, identification, and bioactivities
    Petri Kylli
    Department of Food and Environmental Sciences, University of Helsinki, P O Box 27, 00014 Helsinki, Finland
    J Agric Food Chem 59:3373-84. 2011
    ..The main phenolic compounds in both lingonberries and cranberries were proanthocyanidins comprising 63-71% of the total phenolic content, but anthocyanins, hydroxycinnamic acids, hydroxybenzoic ..
  79. ncbi Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds
    W G Li
    Department of Pharmacology, Lanzhou Medical College, Lanzhou 730000, China
    Acta Pharmacol Sin 22:1117-20. 2001
    To investigate the anti-inflammatory effect and mechanism of proanthocyanidins (PA) from grape seeds.
  80. ncbi Impact of different stages of juice processing on the anthocyanin, flavonol, and procyanidin contents of cranberries
    Brittany L White
    Department of Food Science, University of Arkansas, Fayetteville, Arkansas 72703, United States
    J Agric Food Chem 59:4692-8. 2011
    ..The results indicate that cranberry polyphenolics are relatively stable during processing compared to other berries; however, more work is needed to determine their fate during storage of juices...
  81. pmc Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats
    Nancy Garbacki
    Laboratoire de Physiologie Humaine, CHU, Tour 3, Universite de Liege, Avenue de l Hopital, 3, B 4000 Sart Tilman, Belgium
    BMC Pharmacol 4:25. 2004
    The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats.
  82. ncbi Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease
    Salka Elbøl Rasmussen
    Department of Toxicology and Risk Assessment, Danish Institute for Food and Veterinary Research, Soeborg, Denmark
    Mol Nutr Food Res 49:159-74. 2005
    ..Red wine is rich in the complex polyphenols, the proanthocyanidins, and these compounds have recently attracted attention as potential cardiac-protective compounds...
  83. ncbi Structural analysis of A-type or B-type highly polymeric proanthocyanidins by thiolytic degradation and the implication in their inhibitory effects on pancreatic lipase
    Hideto Kimura
    The Department of Research and Development, Kotobuki Seika Co, Ltd, 2028 Hatagasaki, Yonago, Tottori 683 0845, Japan
    J Chromatogr A 1218:7704-12. 2011
    Compared with oligomeric proanthocyanidins, highly polymeric proanthocyanidins have more difficulty to analyze the molecular sizes and the mode of interflavan linkages of flavan-3-ol units through doubly linked A-type bonds and single B-..
  84. ncbi Cranberry proanthocyanidins: natural weapons against periodontal diseases
    Karine Feghali
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, QC, Canada G1V 0A6
    J Agric Food Chem 60:5728-35. 2012
    Cranberry ( Vaccinium macrocarpon ) is known to have a beneficial effect on several aspects of human health. Proanthocyanidins (PACs), the most abundant flavonoids extracted from red cranberry fruits, have been reported to possess ..
  85. ncbi Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats
    Ximena Terra
    Department of Biochemistry and Biotechnology, Nutrigenomic Research Group, Rovira i Virgili University, Tarragona, 43007, Spain
    J Nutr Biochem 22:380-7. 2011
    ..The dietary regular intake of food or drinks containing procyanidins might help prevent low-grade inflammatory-related diseases...
  86. ncbi Interaction between grape-derived proanthocyanidins and cell wall material. 1. Effect on proanthocyanidin composition and molecular mass
    Keren A Bindon
    The Australian Wine Research Institute, Hartley Grove, Urrbrae, 5064 Adelaide, Australia
    J Agric Food Chem 58:2520-8. 2010
    ..Analysis of proanthocyanidins before and after fining with cell wall material by phloroglucinolysis provided information on recovery by ..
  87. ncbi Characterization of proanthocyanidins in grape seeds using electrospray mass spectrometry
    Yoji Hayasaka
    The Australian Wine Research Institute, PO Box 197, Glen Osmond, SA, 5064, Australia
    Rapid Commun Mass Spectrom 17:9-16. 2003
    ..ES-MS data together with the complementary information provided by acid hydrolysis provides a detailed picture of the composition of grape seed PAs...
  88. ncbi Major phenolics in apple and their contribution to the total antioxidant capacity
    Ki Won Lee
    Department of Food Science and Technology, Cornell University, Geneva, NY 14456, USA
    J Agric Food Chem 51:6516-20. 2003
    ..80) > phloretin (9.11) > chlorogenic acid (8.75). These results indicate that flavonoids such as quercetin, epicatechin, and procyanidin B(2) rather than vitamin C contribute significantly to the total antioxidant activity of apples...
  89. ncbi Biosynthesis and genetic regulation of proanthocyanidins in plants
    Fei He
    Center for Viticulture and Enology, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, PR China
    Molecules 13:2674-703. 2008
    b>Proanthocyanidins (PAs), also known as condensed tannins, are a group of polyphenolic secondary metabolites synthesized in plants as oligomers or polymers of flavan-3-ol units via the flavonoid pathway...
  90. ncbi The Arabidopsis TDS4 gene encodes leucoanthocyanidin dioxygenase (LDOX) and is essential for proanthocyanidin synthesis and vacuole development
    Sharon Abrahams
    CSIRO Plant Industry, GPO Box 1600, Canberra, Australian Capital Territory 2601, Australia
    Plant J 35:624-36. 2003
    ..These results show that in addition to its established role in the formation of anthocyanin, LDOX is also part of the PA biosynthesis pathway...
  91. ncbi Antioxidant effects of a grapeseed procyanidin extract and oleoyl-estrone in obese Zucker rats
    Vanessa M Castrillejo
    Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain
    Nutrition 27:1172-6. 2011
    ....
  92. ncbi Grape seed procyanidin B2 inhibits advanced glycation end product-induced endothelial cell apoptosis through regulating GSK3β phosphorylation
    Bao Ying Li
    Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qilu Hospital of Shandong University, Jinan, Shandong Province, Peoples Republic of China
    Cell Biol Int 35:663-9. 2011
    ..GSPB2 therapy could become an effective approach to battling AGEs-induced endothelial apoptosis...
  93. ncbi Dimeric procyanidin B2 inhibits constitutively active NF-kappaB in Hodgkin's lymphoma cells independently of the presence of IkappaB mutations
    Gerardo G MacKenzie
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Biochem Pharmacol 75:1461-71. 2008
    ..Thus, several signaling pathways should be targeted when designing therapeutics for HL. In this regard, the capacity of B2 to inhibit NF-kappaB could be valuable in a multi-drug approach...
  94. ncbi Influence of vine vigor on grape (Vitis vinifera L. Cv. Pinot Noir) and wine proanthocyanidins
    Jessica M Cortell
    Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331, USA
    J Agric Food Chem 53:5798-808. 2005
    ..monitoring soil, vine growth, yield components, and fruit composition (soluble solids, flavan-3-ol monomers, proanthocyanidins, and pigmented polymers) on a georeferenced grid pattern to assess patterns in growth and development...
  95. ncbi Role of cranberry on bacterial adhesion forces and implications for Escherichia coli-uroepithelial cell attachment
    Paola A Pinzon-Arango
    Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA
    J Med Food 12:259-70. 2009
    ..were grown in tryptic soy broth supplemented with either light cranberry juice cocktail (L-CJC) or cranberry proanthocyanidins (PACs). Growth of E...
  96. ncbi Peanut allergen Ara h 1 interacts with proanthocyanidins into higher molecular weight complexes
    Evelien L van Boxtel
    Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    J Agric Food Chem 55:8772-8. 2007
    ..These proline-rich regions could explain the binding of proanthocyanidins to Ara h 1 and the formation of multiple Ara h 1 trimer complexes...
  97. ncbi Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis
    Xiao Li Li
    Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Department of Pharmacology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
    Can J Physiol Pharmacol 86:841-9. 2008
    The aim of the study was to investigate the therapeutic effect and mechanism of proanthocyanidins from grape seeds (GSPE) in the treatment of ulcerative colitis (UC)...
  98. ncbi Induction of lactadherin mediates the apoptosis of endothelial cells in response to advanced glycation end products and protective effects of grape seed procyanidin B2 and resveratrol
    Bao Ying Li
    Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi Lu Hospital of Shandong University, Jinan, 250012, Shandong Province, People s Republic of China
    Apoptosis 16:732-45. 2011
    ..Targeting lactadherin with antioxidant could be translated into clinical application in the fighting against DM complications...
  99. ncbi Grape seed proanthocyanidin lowers brain oxidative stress in adult and middle-aged rats
    S Asha Devi
    Laboratory of Gerontology, Department of Zoology, Bangalore University, Bangalore, India
    Exp Gerontol 46:958-64. 2011
    ..These results demonstrate that the extent of OS-related LF accumulation is reducible by GSPE. They also suggest a critical role for GSPE as a neuroprotectant in the hippocampus and in preventing cognitive loss with aging...
  100. ncbi Epicatechin is the primary bioavailable form of the procyanidin dimers B2 and B5 after transfer across the small intestine
    J P Spencer
    Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, London SE1 9RT, UK
    Biochem Biophys Res Commun 285:588-93. 2001
    ..The methylation of dimer may be by catechol-O-methyltransferase, however, at high concentrations of dimer COMT activity is reduced leading to an inhibition of both monomer and dimer O-methylation...
  101. ncbi Back-regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathy
    Bao Ying Li
    Department of Geriatrics, Qi Lu Hospital of Shandong University, Jinan, Shandong Province 250012, People s Republic of China
    J Cell Biochem 104:668-79. 2008
    ..Our findings might help to better understanding of the mechanism of DN, and provide novel targets for estimating the effects of GSPE therapy...

Research Grants51

  1. Bioactivity and structure for cranberry proanthocyanidins
    Jess Reed; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Cranberry Proanthocyanidins may be the constituents responsible for the association between consumption of cranberry juice and decreased risks of urinary tract infections because these ..
  2. Inhibition of Reflux-Induced Esophageal Adenocarcinoma by Proanthocyanidins
    Laura A Kresty; Fiscal Year: 2013
    ....
  3. New Mechanisms of Anti-tumor Activity of A-type PACs from Cranberries
    LAURA MARIE BYSTROM; Fiscal Year: 2012
    ..A unique class of compounds from cranberries, known as A-type proanthocyanidins (A-PACs), have iron chelating properties and are the major component of cranberry fractions that have ..
  4. Feasibility of grape seed extract for lung cancer chemoprevention
    Jenny T Mao; Fiscal Year: 2013
    ..Grape seed contains high levels of polyphenols, including proanthocyanidins. These phytochemicals have been shown to modulate carcinogenic mechanisms, including inhibition of the ..
  5. Biomodification of Dentin Matrix Structure
    Ana Karina B Bedran-Russo; Fiscal Year: 2013
    ..to involve interactions between dentin organic components and a family of phytoconstituents, the oligomeric proanthocyanidins (OPCs)...
  6. Prevention of photocarcinogenesis by dietary immunomodulation
    Santosh Kumar Katiyar; Fiscal Year: 2013
    ..We have demonstrated that dietary grape seed proanthocyanidins (GSPs) provide significant protection against UV-induced skin carcinogenesis in an in vivo mouse model and ..
  7. Proanthocyanidins,Novel bioactive components for prevention of melanoma invasion
    Santosh Kumar Katiyar; Fiscal Year: 2013
    ..Dietary bioactive components that have low toxicity are of interest as chemopreventives, including the proanthocyanidins, which do not exhibit gross toxicity in mice...
  8. Prostate Cancer Prevention by Procyanidins in Grape Seed Extract
    Chapla Agarwal; Fiscal Year: 2012
    ..Grape seed extract (GSE), a rich and commercially available source of proanthocyanidins (also known as procyanidins), is usually consumed as a health supplement for its wide range of beneficial ..
  9. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
    ..Our hypothesis is that a higher intake of the flavanol class of flavonoids (which includes the catechins, proanthocyanidins, and flavanones) is associated with a healthier profile of intermediate markers of cardiovascular disease ..
  10. EFFECT OF CRANBERRY CONSTITUENTS ON UTI PATHOGENESIS
    Scott Hultgren; Fiscal Year: 2007
    ..The Vorsa laboratory has fractionated cranberry fruit into the major flavonoid classes of proanthocyanidins, flavonols and anthocyanins...
  11. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    DIANE FEICKERT BIRT; Fiscal Year: 2010
    ..Additionally/our findings may serve as a basis for using botanical extracts and/or constituents for new, low-cost treatments for important human viral infections. ..
  12. Concentrating anti-UTI phytochemicals from cranberry in a functional food matrix
    William May; Fiscal Year: 2012
    ..phytochemicals naturally present in the American cranberry, in particular, the anti-infective A-type proanthocyanidins that are clearly linked to prevention of urinary tract infections (UTIs) in humans, can be efficiently and ..
  13. Dietary flavanols and angiotensin converting enzyme
    Cesar Fraga; Fiscal Year: 2007
    ..This could allow the development of simple and non- expensive strategies aimed to control hypertension and other disorders related to ROS and NO metabolism. ..
  14. Grape Seed Extract-Cardiac Impact and Drug Interaction
    Steven Bolling; Fiscal Year: 2005
    ..Our studies will utilize a standardized grape seed extract IH636, rich in antioxidant proanthocyanidins. Using rabbit cardiac myocyte and whole heart procedures, we will determine if three weeks of IH636 ..
  15. BIOLOGICAL ACTIVITY OF NATURAL PROANTHOCYANIDIN MIXTURES
    Mary Smith; Fiscal Year: 2002
    ..b>Proanthocyanidins have only recently demonstrated important roles in chemoprevention...
  16. Proanthocyanidins: Novel Skin Cancer Preventive Agent
    Santosh Katiyar; Fiscal Year: 2006
    ..Prevention of skin cancer risk will result to protect and prolong the human health and lives. ..
  17. Prevention of UV-carcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2004
    ..abstract_text> ..
  18. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  19. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  20. Identification of Bioactive Cranberry Metabolites
    Amy Howell; Fiscal Year: 2006
    ..b>Proanthocyanidins have been identified as the potential active compounds in cranberry, preventing the in vitro adhesion of P-..
  21. COPPER NUTRITION AND DEVELOPMENT
    Carl Keen; Fiscal Year: 2004
    ..This information should provide new insights into the mechanisms underlying copper deficient pathologies and may contribute to our understanding of this process during human development. ..
  22. Pre & Postdoctoral Training in Nutrition
    Carl Keen; Fiscal Year: 2005
    ..Throughout our training we work to ensure that our graduates have vision and adaptability to work in environments where the skills and views of health professionals trained in nutrition are in urgent demand. ..
  23. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2009
    ..abstract_text> ..
  24. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..Finally, they will examine the effects of the diets on the activation of NFkB and cell signaling pathways. ..
  25. GOLDENSEAL(HYDRASTIS CANADENSIS)REMEDY FOR ORAL DISEASES
    Christine Wu; Fiscal Year: 2002
    ..This application of CAM research will help to achieve better oral health and oral disease prevention, one of the to priority areas of focus specified b the U.S. Public Health Service in "Health People 2000." ..
  26. Effects of Soy on Estrogens in Breast Fluid and Urine
    Gertraud Maskarinec; Fiscal Year: 2010
    ..The NAF approach is the only way to learn more about the beneficial and adverse effects of soy directly in the female breast without applying invasive procedures to women without breast disease or surgery. ..
  27. Nutritional Risk Factors for Type 2 Diabetes in the Multiethnic Cohort
    Gertraud Maskarinec; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  28. Inflammatory Markers in a 2-Year Soy Intervention among Premenopausal Women
    Gertraud Maskarinec; Fiscal Year: 2008
    ..The statistical analysis will apply general linear models to compare the levels of inflammatory markers by soy intake, while taking into account the repeated measurement design. [unreadable] [unreadable] [unreadable] [unreadable]..
  29. Center for Nutrient-Gene Interaction in Cancer Preventi*
    Stephen Barnes; Fiscal Year: 2008
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..
  30. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  31. ESOPHAGEAL ADENOCARCINOGENESIS AND ITS PREVENTION
    Chung Yang; Fiscal Year: 2007
    ..These studies are expected to fully elucidate the roles of oxidative stress and aberrant AA metabolism in the formation of EAC and help develop effective agents for its prevention. ..
  32. CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN AD
    Giulio Pasinetti; Fiscal Year: 2001
    ..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
  33. Integrated Instrumentation for Proteomics
    Helen Kim; Fiscal Year: 2002
    ....
  34. 9.4 Tesla Fourier Transform Mass Spectrometer
    Stephen Barnes; Fiscal Year: 2002
    ..Overall, the FT-MS instrument will sustain the high quality of biomedical research that is a hallmark of UAB. ..
  35. NESTED CASE CONTROL STUDY OF MAMMOGRAPHIC DENSITY
    Gertraud Maskarinec; Fiscal Year: 2002
    ....
  36. MATHEMATICAL MODELING IN NUTRITION
    James Hargrove; Fiscal Year: 2003
    ..Lastly, a panel will discuss the use of modeling in undergraduate and graduate education, and will make recommendations for appropriate activities of a new Research Interest Section on Mathematical Modeling. ..
  37. Blueprints for Transforming Research at UIC College of Dentistry
    Christine Wu; Fiscal Year: 2003
    ..With the systematic infrastructure improvement initiative, and through integration of interdisciplinary research and creation of critical mass, UIC COD will play a leading role in US academic dentistry. ..
  38. A sensitive triple quadrupole mass spectrometer
    Stephen Barnes; Fiscal Year: 2004
    ..It is anticipated that a commercial nanospray interface for use in nanoLC-MS analysis will be available by the fall of 2003. ..
  39. Breast Density, IGF-I, & Prolactin, in Four Populations
    Gertraud Maskarinec; Fiscal Year: 2004
    ..The statistical analysis will include mixed models to explore the relation between hormone levels and breast density while controlling for confounders and for clustering by study location. ..
  40. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  41. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Chung Yang; Fiscal Year: 2005
    ..Jointly, we intend to make major contributions to the use of tea for the I chemoprevention of cancer. ..
  42. Soy Consumption and Breast Tissue Proliferation
    Gertraud Maskarinec; Fiscal Year: 2006
    ....
  43. AMINO ACID CONJUGATION OF BILE ACIDS
    Stephen Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  44. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
  45. COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASE
    Giulio Pasinetti; Fiscal Year: 2002
    ..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
  46. Targeting Histone Deacetylation: A Tool for Chemopevention of Esophageal Cancer
    Laura Kresty; Fiscal Year: 2008
    ..goal of identifying and translating efficacious preventive agents into the clinic for evaluation in high risk human cohorts, including patients with long standing Barrett's esophagus or [unreadable] [unreadable] [unreadable]..
  47. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    ....
  48. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2006
    ..abstract_text> ..
  49. APPLICATION OF NOVEL OPTICAL METHODS TO CELL DYNAMICS
    Alan Verkman; Fiscal Year: 2001
    ..These studies will address the hypothesis that the membrane skeleton of these cells is a mobile, dynamic structure. ..
  50. PHYSIOLOGY AND MOLECULAR BIOLOGY OF LUNG WATER TRANSPORT
    Alan Verkman; Fiscal Year: 2007
    ..abstract_text> ..