troponin t

Summary

Summary: One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.

Top Publications

  1. ncbi Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population
    James A de Lemos
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75390 9047, USA
    JAMA 304:2503-12. 2010
  2. pmc Muscleblind proteins regulate alternative splicing
    Thai H Ho
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 23:3103-12. 2004
  3. ncbi Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
  4. pmc Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study
    Justin T Saunders
    6565 Fannin, MS A 601, Houston, TX 77030, USA
    Circulation 123:1367-76. 2011
  5. pmc A sensitive cardiac troponin T assay in stable coronary artery disease
    Torbjørn Omland
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway
    N Engl J Med 361:2538-47. 2009
  6. ncbi Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
    Amy J Sehnert
    Department of Biochemistry and Biophysics, University of California at San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143 0448, USA
    Nat Genet 31:106-10. 2002
  7. pmc Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction
    Ying Qing Li
    Sun Yat Sen University, The First Affiliated Hospital, Department of Emergency, Guangzhou, People s Republic of China
    Clinics (Sao Paulo) 68:75-80. 2013
  8. ncbi Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 116:1242-9. 2007
  9. ncbi Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism
    Mareike Lankeit
    Department of Cardiology and Pulmonology, University of Gottingen, 37099 Gottingen, Germany
    Eur Heart J 31:1836-44. 2010
  10. ncbi National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes
    David A Morrow
    Brigham and Women s Hospital, Harvard University, Boston, MA, USA
    Circulation 115:e356-75. 2007

Detail Information

Publications343 found, 100 shown here

  1. ncbi Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population
    James A de Lemos
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75390 9047, USA
    JAMA 304:2503-12. 2010
    Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk of death and adverse cardiovascular events; however, cTnT is rarely detectable in the general population using ..
  2. pmc Muscleblind proteins regulate alternative splicing
    Thai H Ho
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    EMBO J 23:3103-12. 2004
    ..that MBNL proteins regulate alternative splicing of two pre-mRNAs that are misregulated in DM, cardiac troponin T (cTNT) and insulin receptor (IR)...
  3. ncbi Sensitive troponin I assay in early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    N Engl J Med 361:868-77. 2009
    ..Cardiac troponin testing is central to the diagnosis of acute myocardial infarction. We evaluated a sensitive troponin I assay for the early diagnosis and risk stratification of myocardial infarction...
  4. pmc Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study
    Justin T Saunders
    6565 Fannin, MS A 601, Houston, TX 77030, USA
    Circulation 123:1367-76. 2011
    We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated with incident coronary heart disease (CHD), mortality, and hospitalization for heart failure (HF) in a general population of ..
  5. pmc A sensitive cardiac troponin T assay in stable coronary artery disease
    Torbjørn Omland
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway
    N Engl J Med 361:2538-47. 2009
    In most patients with stable coronary artery disease, plasma cardiac troponin T levels are below the limit of detection for the conventional assay...
  6. ncbi Cardiac troponin T is essential in sarcomere assembly and cardiac contractility
    Amy J Sehnert
    Department of Biochemistry and Biophysics, University of California at San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143 0448, USA
    Nat Genet 31:106-10. 2002
    Mutations of the gene (TNNT2) encoding the thin-filament contractile protein cardiac troponin T are responsible for 15% of all cases of familial hypertrophic cardiomyopathy, the leading cause of sudden death in young athletes...
  7. pmc Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction
    Ying Qing Li
    Sun Yat Sen University, The First Affiliated Hospital, Department of Emergency, Guangzhou, People s Republic of China
    Clinics (Sao Paulo) 68:75-80. 2013
    ..of this study were to evaluate the expression of cardiac-specific miRNAs (miR-1, -133a, -208b, and -499) in patients with acute myocardial infarction and to compare the diagnostic values of these miRNAs with that of cardiac troponin T.
  8. ncbi Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure
    Roberto Latini
    Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 116:1242-9. 2007
    Circulating cardiac troponin T, a marker of cardiomyocyte injury, predicts adverse outcome in patients with heart failure (HF) but is detectable in only a small fraction of those with chronic stable HF...
  9. ncbi Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism
    Mareike Lankeit
    Department of Cardiology and Pulmonology, University of Gottingen, 37099 Gottingen, Germany
    Eur Heart J 31:1836-44. 2010
    To assess the role of cardiac troponin T (cTnT) levels on admission using a new, highly sensitive assay (hsTnT) in the risk assessment of normotensive patients with acute pulmonary embolism (PE).
  10. ncbi National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes
    David A Morrow
    Brigham and Women s Hospital, Harvard University, Boston, MA, USA
    Circulation 115:e356-75. 2007
  11. pmc Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults
    Christopher R DeFilippi
    Department of Medicine, G3K63, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21212, USA
    JAMA 304:2494-502. 2010
    ..Older adults comprise the majority of new-onset heart failure (HF) diagnoses, but traditional risk-factor prediction models have limited accuracy in this population to identify those at highest risk for hospitalization or death...
  12. ncbi Serial measurement of cardiac troponin T using a highly sensitive assay in patients with chronic heart failure: data from 2 large randomized clinical trials
    Serge Masson
    Department of Cardiovascular Research, Istituto Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Circulation 125:280-8. 2012
    ..Less is known about the relation between serial measurements of high-sensitivity cardiac troponin T (hs-cTnT) and future events in HF...
  13. ncbi Effect of competitive marathon cycling on plasma N-terminal pro-brain natriuretic peptide and cardiac troponin T in healthy recreational cyclists
    Guenther Neumayr
    Institute of Sports Medicine and Cardiovascular Medicine, University Clinics of Innsbruck, Innsbruck, Austria
    Am J Cardiol 96:732-5. 2005
    ..of exercise-induced cardiac dysfunction, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and cardiac troponin T (cTnT) were measured in recreational cyclists (n = 29) during the Otztal Radmarathon 2004...
  14. pmc Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs
    Yuan Yuan
    Department of Molecular Genetics and Microbiology and the Genetics Institute, University of Florida, College of Medicine, Gainesville, FL, USA
    Nucleic Acids Res 35:5474-86. 2007
    ..Our results provide a mechanistic basis for dsCUG-induced MBNL1 sequestration and highlight a striking similarity in the binding sites for MBNL proteins on splicing precursor and pathogenic RNAs...
  15. ncbi Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere
    L Thierfelder
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Cell 77:701-12. 1994
    ..implicated components of the troponin complex as candidate genes at other FHC loci, particularly cardiac troponin T, which was mapped in this study to chromosome 1q...
  16. ncbi Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy
    M Kamisago
    Cardiovascular Division, Brigham and Women s Hospital, and Harvard Medical School and Howard Hughes Medical Institute, Boston, MA, USA
    N Engl J Med 343:1688-96. 2000
    ..To elucidate this important cause of heart failure, we investigated other genetic causes of dilated cardiomyopathy...
  17. ncbi Incremental value of copeptin for rapid rule out of acute myocardial infarction
    Tobias Reichlin
    Department of Internal Medicine, University Hospital, Basel, Switzerland
    J Am Coll Cardiol 54:60-8. 2009
    ..The purpose of this study was to examine the incremental value of copeptin for rapid rule out of acute myocardial infarction (AMI)...
  18. ncbi Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis
    Nadia A Khan
    Division of Internal Medicine, University of British Columbia, Canada
    Circulation 112:3088-96. 2005
    ....
  19. ncbi Prevalence and determinants of troponin T elevation in the general population
    Thomas W Wallace
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 113:1958-65. 2006
    The prevalence and determinants of cardiac troponin T (cTnT) elevation in the general population are unknown, and the significance of minimally increased cTnT remains controversial...
  20. ncbi Soluble ST2, high-sensitivity troponin T- and N-terminal pro-B-type natriuretic peptide: complementary role for risk stratification in acutely decompensated heart failure
    Domingo A Pascual-Figal
    Cardiology Department, Virgen de la Arrixaca Hospital and School of Medicine, University of Murcia, Murcia, Spain
    Eur J Heart Fail 13:718-25. 2011
    ..To investigate the use of biomarkers providing independent information regarding physiology in acutely decompensated heart failure (ADHF) for assessment of risk...
  21. pmc Troponin T for the detection of dialysis-induced myocardial stunning in hemodialysis patients
    Tobias Breidthardt
    School of Graduate Entry Medicine and Health, University of Nottingham Medical School at Derby and Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom
    Clin J Am Soc Nephrol 7:1285-92. 2012
    Circulating troponin T levels are frequently elevated in patients undergoing long-term dialysis. The pathophysiology underlying these elevations is controversial.
  22. ncbi Haemodialysis patients longitudinally assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and cardiac troponin I assays
    Leo H Jacobs
    Department of Clinical Chemistry, University Hospital Maastricht, Maastricht 6202 AZ, The Netherlands
    Ann Clin Biochem 46:283-90. 2009
    ..This study compares the performance of a precommercial high-sensitive cTnT assay (hs-cTnT) with two contemporary cTn assays in detecting cTn elevations in ESRD patients during a six-month follow-up...
  23. ncbi Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy
    H Watkins
    Howard Hughes Medical Institute, Boston, MA
    N Engl J Med 332:1058-64. 1995
    ..can be caused by mutations in the genes for beta cardiac myosin heavy chain, alpha-tropomyosin, or cardiac troponin T. It is not known how often the disease is caused by mutations in the tropomyosin and troponin genes, and the ..
  24. ncbi Is serum troponin T a useful marker of myocardial damage in newborn infants with perinatal asphyxia?
    S Costa
    Division of Neonatology, Catholic University of the Sacred Heart, Rome, Italy
    Acta Paediatr 96:181-4. 2007
    To assess the correlation of echocardiographic signs of myocardial damage to serum cardiac troponin T (cTnT) concentrations in newborn infants with perinatal asphyxia.
  25. ncbi Elevated high-sensitivity cardiac troponin T is associated with increased mortality after acute exacerbation of chronic obstructive pulmonary disease
    A D Høiseth
    Department of Medicine, Akershus University Hospital, 1478 Lørenskog, Norway
    Thorax 66:775-81. 2011
    ..In the present prospective study the prevalence and prognostic value of elevated cardiac troponin T (cTnT) in unselected patients with AECOPD have been investigated, using a novel high-sensitivity assay (hs-cTnT ..
  26. pmc Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy
    S Morimoto
    Laboratory of Clinical Pharmacology, Department of Pharmacology, Graduate School of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 99:913-8. 2002
    A deletion mutation Delta K210 in cardiac troponin T (cTnT) was recently found to cause familial dilated cardiomyopathy (DCM)...
  27. ncbi Copeptin improves early diagnosis of acute myocardial infarction
    Till Keller
    Department of Medicine II, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    J Am Coll Cardiol 55:2096-106. 2010
    ..Early identification of myocardial infarction in chest pain patients is crucial to identify patients at risk and to maintain a fast treatment initiation...
  28. ncbi Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype
    Mahmooda Mirza
    National Heart and Lung Institute, Imperial College London, London SW3 6LY, United Kingdom
    J Biol Chem 280:28498-506. 2005
    ..Inherited DCM can result from mutations in the genes encoding cardiac troponin T, troponin C, and alpha-tropomyosin; different mutations in the same genes cause hypertrophic cardiomyopathy...
  29. ncbi Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes
    Arman S Postadzhiyan
    Medical University Sofia, Bulgaria
    Clin Biochem 41:126-33. 2008
    ....
  30. ncbi Detectable serum cardiac troponin T as a marker of poor prognosis among patients with chronic precapillary pulmonary hypertension
    Adam Torbicki
    Department of Chest Medicine, Institute of Tuberculosis and Lung Diseases, Medical University of Warsaw, Poland
    Circulation 108:844-8. 2003
    ..We checked whether detection of cardiac troponin T (cTnT), a specific marker of myocyte injury, could be useful in prognostic stratification of those patients.
  31. pmc Diagnostic performance of high-sensitivity troponin T, myeloperoxidase, and pregnancy-associated plasma protein A assays for triage of patients with acute myocardial infarction
    Dilshad Ahmed Khan
    Department of Pathology, Army Medical College National University of Sciences and Technology, Islamabad, Pakistan
    Korean J Lab Med 31:172-8. 2011
    ..We aimed to compare the diagnostic accuracy of high-sensitivity troponin T (hs-cTnT) with myeloperoxidase (MPO) and pregnancy-associated plasma protein A (PAPP-A) for early diagnosis of ..
  32. ncbi Combined testing of high-sensitivity troponin T and copeptin on presentation at prespecified cutoffs improves rapid rule-out of non-ST-segment elevation myocardial infarction
    Evangelos Giannitsis
    Medizinische Klinik, Abteilung für Innere Medizin III, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Clin Chem 57:1452-5. 2011
    ..We prospectively tested whether copeptin adds information to that provided by a high-sensitivity cardiac troponin T (hscTnT) assay in the early evaluation of patients with suspected acute myocardial infarction, particularly non-..
  33. pmc Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region
    T Palm
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Biophys J 81:2827-37. 2001
    Fifteen percent of the mutations causing familial hypertrophic cardiomyopathy are in the troponin T gene...
  34. ncbi Arterial stiffness is associated with minimally elevated high-sensitivity cardiac, troponin T levels in a community-dwelling population
    Yongyi Bai
    Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China
    Atherosclerosis 218:493-8. 2011
    ..Minimally elevated levels of plasma cardiac troponin T (TnT), a marker of cardiomyocyte injury, can be detected by the high-sensitivity TnT (hsTnT) assay...
  35. ncbi High-sensitive troponin T: a novel biomarker for prognosis and disease severity in patients with pulmonary arterial hypertension
    Arthur Filusch
    Department of Cardiology, Angiology and Respiratory Medicine, University Medical Center, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
    Clin Sci (Lond) 119:207-13. 2010
    ..However, rarely detectable, cTnT [cardiac TnT (troponin T)] is a significant prognostic marker...
  36. ncbi Severe familial left ventricular non-compaction cardiomyopathy due to a novel troponin T (TNNT2) mutation
    Mark Luedde
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Cardiovasc Res 86:452-60. 2010
    ..Here, we describe a family with LVNC due to a novel missense mutation, pE96K, in the cardiac troponin T gene (TNNT2).
  37. pmc Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size
    M Licka
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Heart 87:520-4. 2002
    ..considerably longer than cytosolic creatine kinase (CK), CK MB isoenzyme (CK-MB), or lactate dehydrogenase (LDH) and late troponin T release (> 48 hours after onset of chest pain) appears to be less affected by early coronary reperfusion.
  38. ncbi Different functional properties of troponin T mutants that cause dilated cardiomyopathy
    Gayathri Venkatraman
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, 1600 NW 10th Avenue, Miami, FL 33101, USA
    J Biol Chem 278:41670-6. 2003
    The effects of Troponin T (TnT) mutants R141W and DeltaK210, the only two currently known mutations in TnT that cause dilated cardiomyopathy(DCM) independent of familial hypertrophic cardiomyopathy (FHC), and TnT-K273E, a mutation that ..
  39. ncbi Copeptin does not add diagnostic information to high-sensitivity troponin T in low- to intermediate-risk patients with acute chest pain: results from the rule out myocardial infarction by computed tomography (ROMICAT) study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 57:1137-45. 2011
    ..sought to evaluate the predictive value of copeptin and its incremental value beyond that of high-sensitivity cardiac troponin T (hs-cTnT) in patients with acute chest pain and low to intermediate risk for acute coronary syndrome (ACS).
  40. ncbi Early diagnosis of acute myocardial infarction in the elderly using more sensitive cardiac troponin assays
    Miriam Reiter
    Department of Internal Medicine, University Hospital, Petersgraben 4, CH 4031 Basel, Switzerland
    Eur Heart J 32:1379-89. 2011
    ..To examine the diagnostic accuracy of sensitive cardiac troponin (cTn) assays in elderly patients, since elevated levels with sensitive cTn assays were reported in 20% of elderly patients without acute myocardial infarction (AMI)...
  41. ncbi Prognostic value of sensitive troponin T in patients with stable and unstable angina and undetectable conventional troponin
    Gjin Ndrepepa
    Deutsches Herzzentrum, Technische Universitat, Munich, Germany
    Am Heart J 161:68-75. 2011
    ..The objective of this study was to investigate the prognostic value of sensitive cardiac troponin in patients with stable and unstable angina presenting with undetectable levels of conventional troponin...
  42. ncbi Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
    Andrew E Messer
    National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    J Mol Cell Cardiol 42:247-59. 2007
    ..The troponin T phosphorylation level was the same in troponin from failing and non-failing heart (3.1 mol Pi/mol)...
  43. ncbi The role of a common TNNT2 polymorphism in cardiac hypertrophy
    Kazuo Komamura
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    J Hum Genet 49:129-33. 2004
    ..In conclusion, TNNT2 deletion allele could be associated with a predisposition to prominent left ventricular hypertrophy...
  44. ncbi Analytical characteristics of high-sensitivity cardiac troponin assays
    Fred S Apple
    Hennepin County Medical Center, Minneapolis, MN 55415, USA
    Clin Chem 58:54-61. 2012
    ..An evidence-based clinical database is growing rapidly for high-sensitivity (hs) troponin assays. Thus, clarifications of the analytical principles for the immunoassays used in clinical practice are important...
  45. ncbi One-hour rule-out and rule-in of acute myocardial infarction using high-sensitivity cardiac troponin T
    Tobias Reichlin
    Department of Cardiology, University Hospital Basel, Switzerland
    Arch Intern Med 172:1211-8. 2012
    ..Our objective was to develop and validate an algorithm for rapid rule-out and rule-in of AMI...
  46. ncbi Release of cardiac troponin in acute coronary syndromes: ischemia or necrosis?
    A H Wu
    Department of Pathology and Laboratory Medicine, Hartford Hospital, CT, USA
    Clin Chim Acta 284:161-74. 1999
    Analysis of cardiac troponin T and I have been shown to be effective in detecting minor myocardial injury in cardiac patients who present with acute coronary syndromes (ACS)...
  47. ncbi Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: a pilot experimental study
    Martin Albrecht
    Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Schwanenweg 21, 24105 Kiel, Germany
    Basic Res Cardiol 108:314. 2013
    ..RIPC patients showed reduced troponin T serum concentrations in the first 48 h after surgery (P < 0.05 vs...
  48. pmc Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy
    J C Tardiff
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    J Clin Invest 104:469-81. 1999
    Multiple mutations in cardiac troponin T (cTnT) can cause familial hypertrophic cardiomyopathy (FHC)...
  49. ncbi Combined use of high-sensitivity cardiac troponin T and N-terminal pro-B type natriuretic peptide improves measurements of performance over established mortality risk factors in chronic heart failure
    Marta de Antonio
    Heart Failure Unit, Hospital Universitari Germans Trias i Pujol, Carretera de Canyet s n, Badalona, Spain
    Am Heart J 163:821-8. 2012
    ..The objective was to assess high-sensitivity cardiac troponin T (hs-cTnT) in combination with N-terminal pro-B type natriuretic peptide (NT-proBNP) for risk stratification in a ..
  50. pmc Association of cardiac troponin T with left ventricular structure and function in CKD
    Rakesh K Mishra
    University of California, San Francisco, CA, USA
    Am J Kidney Dis 61:701-9. 2013
    Serum cardiac troponin T (cTnT) is associated with increased risk of heart failure and cardiovascular death in several population settings...
  51. pmc Combined determination of highly sensitive troponin T and copeptin for early exclusion of acute myocardial infarction: first experience in an emergency department of a general hospital
    Ulrich Lotze
    Department of Internal Medicine, German Red Cross Hospital Sondershausen, Sondershausen, Germany
    Vasc Health Risk Manag 7:509-15. 2011
    The purpose of this observational study was to test the diagnostic performance of the Elecsys® troponin T high-sensitive system combined with copeptin measurement for early exclusion of acute myocardial infarction (MI) in clinical ..
  52. pmc Diagnostic and prognostic utility of early measurement with high-sensitivity troponin T assay in patients presenting with chest pain
    Sally J Aldous
    Christchurch Hospital, Christchurch, New Zealand
    CMAJ 184:E260-8. 2012
    ..High-sensitivity troponin assays are now available for clinical use. We investigated whether early measurement with such an assay is superior to a conventional assay in the evaluation of acute coronary syndromes...
  53. pmc Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarction
    Youlan L Gu
    Department of Cardiology, Thorax Center, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Clin Res Cardiol 100:1069-76. 2011
    ..of the C-terminal portion of provasopressin (copeptin) with conventional cardiac biomarkers, including creatine kinase isoenzyme (CK-MB), cardiac troponin T (cTnT), and high-sensitivity cTnT (hs-cTnT), in patients with ST-elevation AMI.
  54. ncbi F110I and R278C troponin T mutations that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers
    Olga M Hernandez
    Department of Pharmacology, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 280:37183-94. 2005
    We have studied the physiological effects of the troponin T (TnT) F110I and R278C mutations associated with familial hypertrophic cardiomyopathy (FHC) in humans...
  55. ncbi Diagnostic and prognostic impact of copeptin and high-sensitivity cardiac troponin T in patients with pre-existing coronary artery disease and suspected acute myocardial infarction
    Mihael Potocki
    Department of Cardiology, University Hospital Basel, Basel, Switzerland
    Heart 98:558-65. 2012
    ..The early diagnosis of acute myocardial infarction (AMI) can be particularly challenging in patients with known coronary artery disease (CAD) due to pre-existing ECG changes and chronic increases in cardiac troponin (cTn) levels...
  56. ncbi High-sensitive cardiac troponin T outperforms novel diagnostic biomarkers in patients with acute chest pain
    Kai M Eggers
    Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
    Clin Chim Acta 413:1135-40. 2012
    ..However, the information obtained from hs-cTnT levels might be improved when combined with results of other biomarkers of myocardial injury...
  57. pmc Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis
    Marta Vicente-Crespo
    Department of Genetics, University of Valencia, Valencia, Spain
    PLoS ONE 3:e1613. 2008
    ..Such transition fails in the CTG repeat expansion disease myotonic dystrophy due, in part, to sequestration of MBNL proteins by CUG repeat RNA. Four protein isoforms (MblA-D) are coded by the unique Drosophila muscleblind gene...
  58. ncbi Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy
    Yuan Yuan Wang
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cardiovasc Res 87:636-46. 2010
    ..Thyroid hormone (TH) has prominent effects on the heart, and hyperthyroidism is occasionally found to be a cause of dilated cardiomyopathy (DCM). We aim to explore the potential role of TH in the pathogenesis of DCM...
  59. ncbi Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation
    Dong Yun Zhan
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cardiovasc Res 84:64-71. 2009
    ..Using a mouse model of inherited DCM with a troponin mutation, we aim to study the treatment benefits of beta-blockers...
  60. ncbi Decision making with cardiac troponin tests
    Elliott M Antman
    N Engl J Med 346:2079-82. 2002
  61. ncbi Cardiac troponin T isoforms demonstrate similar effects on mechanical performance in a regulated contractile system
    Peter VanBuren
    Cardiology Unit, Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Heart Circ Physiol 282:H1665-71. 2002
    Alteration of troponin T (TnT) isoform expression has been reported in human and animal models of myocardial failure. The two adult beef cardiac TnT isoforms (TnT(3) and TnT(4)) were isolated for comparative functional analysis...
  62. pmc Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study
    Aslan T Turer
    Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75230 9047, USA
    J Am Coll Cardiol 57:2398-405. 2011
    The purpose of this study was to assess whether: 1) very small increases in troponin T, measured by a new highly sensitive cardiac troponin T (hs-cTnT), may reflect ischemia without necrosis; and 2) serial changes can discriminate ..
  63. ncbi Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Division of Cardiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02115 2696, USA
    Circulation 114:2325-33. 2006
    ....
  64. ncbi Association between high-sensitivity cardiac troponin T levels and the predicted cardiovascular risk in middle-aged men without overt cardiovascular disease
    Toshiaki Otsuka
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Am Heart J 159:972-8. 2010
    A slight elevation of cardiac troponin T (TnT) levels in the circulating blood can be detected by the recently developed, high-sensitivity TnT (hsTnT) assay...
  65. ncbi Predictive value of C-reactive protein and troponin T in patients with unstable angina: a comparative analysis. CAPTURE Investigators. Chimeric c7E3 AntiPlatelet Therapy in Unstable angina REfractory to standard treatment trial
    C Heeschen
    Stanford University Medical School, Department of Cardiovascular Medicine, California 94305 5406, USA
    J Am Coll Cardiol 35:1535-42. 2000
    We evaluated C-reactive protein (CRP) and troponin T (TnT) for predicting six-month cardiac risk in patients with unstable angina.
  66. pmc Sensitive cardiac troponin T assay and the risk of incident cardiovascular disease in women with and without diabetes mellitus: the Women's Health Study
    Brendan M Everett
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    Circulation 123:2811-8. 2011
    Very low levels of cardiac troponin T are associated with an increased risk of cardiovascular death in patients with stable chronic coronary disease...
  67. pmc Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients
    Sangeetha Satyan
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 50:1009-19. 2007
    Although the cardiac biomarker troponin T (cTnT) is related strongly to mortality in patients with end-stage renal disease, the independent association of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and cTnT levels in ..
  68. ncbi Over time, high-sensitivity TnT replaces NT-proBNP as the most powerful predictor of death in patients with dialysis-dependent chronic renal failure
    Darryl McGill
    Department of Cardiology, Canberra Hospital, Garran, ACT 2605, Australia
    Clin Chim Acta 411:936-9. 2010
    ..The optimal biomarker and/or combination of biomarkers for predicting mortality remain uncertain. This study evaluates the prognostic value of the new high-sensitivity troponin T (TnT) assay compared to established biomarkers.
  69. ncbi Determinants of troponin release in patients with stable coronary artery disease: insights from CT angiography characteristics of atherosclerotic plaque
    Grigorios Korosoglou
    University of Heidelberg, Department of Cardiology, Im Neuenheimer Feld 410, Heidelberg, 69120, Germany
    Heart 97:823-31. 2011
    ..the determinants of troponin release in patients with stable coronary artery disease (CAD) by comparing high sensitive troponin T (hsTnT) levels with computed tomography angiography (CTA) characteristics of atherosclerotic plaque.
  70. ncbi Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin
    E H Herman
    Division of Applied Pharmacology Research HFD 910, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD 20708, USA
    J Clin Oncol 17:2237-43. 1999
    ..To investigate, over a wide range of cumulative doxorubicin doses, the feasibility of using serum concentrations of cardiac troponin-T (cTnT) as a biomarker for doxorubicin-induced myocardial damage...
  71. ncbi A muscleblind knockout model for myotonic dystrophy
    Rahul N Kanadia
    Department of Molecular Genetics and Microbiology, Powell Gene Therapy Center, Gainesville, FL 32610, USA
    Science 302:1978-80. 2003
    ..Our results support the hypothesis that manifestations of DM can result from sequestration of specific RNA binding proteins by a repetitive element expansion in a mutant RNA...
  72. pmc Identification of CELF splicing activation and repression domains in vivo
    Jin Han
    Department of Pathology, Baylor College of Medicine Houston, TX 77030, USA
    Nucleic Acids Res 33:2769-80. 2005
    ..These results provide a foundation for identifying CELF-interacting proteins involved in activated and/or repressed splicing...
  73. ncbi Role of troponin T in disease
    Aldrin V Gomes
    Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Mol Cell Biochem 263:115-29. 2004
    Several striated muscle myopathies have been directly linked to mutations in contractile and associated proteins. Troponin T (TnT) is one of the three subunits that form troponin (Tn) which together with tropomyosin is responsible for the ..
  74. ncbi Cardiac troponins and renal function in nondialysis patients with chronic kidney disease
    Nasir A Abbas
    Department of Renal Medicine, East Kent Hospitals NHS Trust, Canterbury, UK
    Clin Chem 51:2059-66. 2005
    ..The data on cardiac troponin I (cTnI) are more variable than those for cardiac troponin T (cTnT)...
  75. ncbi Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy
    Paul Robinson
    Department of Cardiovascular Medicine, Wellcome Trust Center for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Biol Chem 277:40710-6. 2002
    ..compared the in vitro regulatory properties of recombinant human cardiac troponin reconstituted using wild type troponin T with troponin containing the DeltaLys-210 troponin T mutant that causes dilated cardiomyopathy (DCM) and the ..
  76. ncbi The prognostic value of troponin in patients with non-ST elevation acute coronary syndromes: a meta-analysis
    P A Heidenreich
    Veterans Affairs Palo Alto Health Care System, California 94304, USA
    J Am Coll Cardiol 38:478-85. 2001
    ..This study was designed to compare the prognostic value of an abnormal troponin level derived from studies of patients with non-ST elevation acute coronary syndromes (ACS)...
  77. ncbi Myocardial damage in falciparum malaria detectable by cardiac troponin T is rare
    A Gunther
    Institut fur Tropenmedizin, Charite, Humboldt Universitat zu Berlin, Germany
    Trop Med Int Health 8:30-2. 2003
    To estimate the prevalence of myocardial damage in falciparum malaria by serum concentration of cardiac troponin T.
  78. ncbi Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction
    Julien Ochala
    Department of Neuroscience, Clinical Neurophysiology, University Hospital, Entrance 85, SE 751 85, Uppsala, Sweden
    J Mol Med (Berl) 86:1197-204. 2008
    ..alpha-actin, beta-tropomyosin, gamma-tropomyosin, fast skeletal muscle troponin I, slow skeletal muscle troponin T, fast skeletal muscle troponin T, and nebulin, respectively) have been identified...
  79. ncbi Cardiac troponins in renal insufficiency: review and clinical implications
    Benjamin J Freda
    Department of Internal Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    J Am Coll Cardiol 40:2065-71. 2002
    ..Serum troponin T is increased more frequently than troponin I in patients with renal failure, leading clinicians to question its ..
  80. ncbi Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy
    F Yanaga
    Department of Clinical Pharmacology, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 274:8806-12. 1999
    Human wild-type cardiac troponin T, I, C and five troponin T mutants (I79N, R92Q, F110I, E244D, and R278C) causing familial hypertrophic cardiomyopathy were expressed in Escherichia coli, and then were purified and incorporated into ..
  81. pmc Minimally elevated cardiac troponin T and elevated N-terminal pro-B-type natriuretic peptide predict mortality in older adults: results from the Rancho Bernardo Study
    Lori B Daniels
    Division of Cardiology, Department of Medicine, University of California at San Diego, San Diego, California, USA
    J Am Coll Cardiol 52:450-9. 2008
    This study investigated the prognostic value of detectable cardiac troponin T (TnT) and elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in a population of community-dwelling older adults.
  82. ncbi HMGB1 as a predictor of infarct transmurality and functional recovery in patients with myocardial infarction
    M Andrassy
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Intern Med 270:245-53. 2011
    ..The aim of this study was to analyse serum HMGB1 concentration and its correlation with infarct transmurality and functional recovery in patients with ST-elevation (STEMI) and non-ST-elevation myocardial infarction (NSTEMI)...
  83. ncbi Highly sensitive cardiac troponin T values remain constant after brief exercise- or pharmacologic-induced reversible myocardial ischemia
    Kerstin Kurz
    Department of Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Clin Chem 54:1234-8. 2008
    Using a new precommercial high-sensitivity cardiac troponin T (hsTnT) assay, we evaluated whether hsTnT increases after reversible myocardial ischemia.
  84. ncbi Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function
    Q Q Huang
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Cell Physiol 294:C213-22. 2008
    In contrast to skeletal muscles that simultaneously express multiple troponin T (TnT) isoforms, normal adult human cardiac muscle contains a single isoform of cardiac TnT...
  85. ncbi Analytical validation of a high-sensitivity cardiac troponin T assay
    Evangelos Giannitsis
    Medizinische Klinik, Abteilung für Innere Medizin III, Universitatsklinikum Heidelberg, Germany
    Clin Chem 56:254-61. 2010
    We report the development of a novel high-sensitivity cardiac troponin T (hs-cTnT) assay, a modification of the Roche fourth-generation cTnT assay, and validation of the analytical performance of this assay.
  86. ncbi Prognostic usefulness of circulating high-sensitivity troponin T in aortic stenosis and relation to echocardiographic indexes of cardiac function and anatomy
    Helge Røsjø
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway
    Am J Cardiol 108:88-91. 2011
    The new high-sensitivity cardiac troponin T (hs-cTnT) assay seems to provide important prognostic information in patients with stable cardiovascular disease...
  87. ncbi Measurement of a plasma stroke biomarker panel and cardiac troponin T in marathon runners before and after the 2005 Boston marathon
    Adam J Saenz
    Division of Laboratory Medicine, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Clin Pathol 126:185-9. 2006
    ....
  88. pmc The C-terminus of troponin T is essential for maintaining the inactive state of regulated actin
    Andrew J Franklin
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA
    Biophys J 102:2536-44. 2012
    ..Deletion of the 14 C-terminal residues of cardiac troponin T leads to hypertrophic cardiomyopathy...
  89. ncbi Biochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPD
    Catherina L Chang
    Department of Respiratory Medicine, Waikato Hospital, Level 01 Menzies Building, Hamilton 3204, New Zealand
    Thorax 66:764-8. 2011
    ..studies suggest that plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T are often elevated in patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) and are ..
  90. ncbi A molecular screening strategy based on beta-myosin heavy chain, cardiac myosin binding protein C and troponin T genes in Italian patients with hypertrophic cardiomyopathy
    Francesca Girolami
    Genetic Diagnostic Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    J Cardiovasc Med (Hagerstown) 7:601-7. 2006
    ..for most known mutations: beta-myosin heavy chain (MYH7), cardiac myosin binding protein C (MYBPC3) and cardiac troponin T (TNNT2). Their prevalence in Italian HCM patients is unknown...
  91. pmc Determinants of high-sensitivity cardiac troponin T during acute exacerbation of chronic obstructive pulmonary disease: a prospective cohort study
    Arne Didrik Høiseth
    Dept, of Medicine, Akershus University Hospital and Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, Oslo, Norway
    BMC Pulm Med 12:22. 2012
    A high-sensitivity cardiac troponin T (hs-cTnT) concentration above the 99th percentile (i.e. 14 ng/L) is common during Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) and associated with increased mortality...
  92. pmc Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy
    Ray E Hershberger
    Division of Cardiovascular Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circ Cardiovasc Genet 2:306-13. 2009
    ..This is critically important as genetic DCM, usually presenting with advanced, life-threatening disease, may be preventable with early intervention in relatives known to carry the mutation...
  93. ncbi Cardiac troponin T and end stage renal disease
    Alaa Eldin M Gabr
    Department of Internal Medicine, King Fahd Specialist Hospital, PO Box 2290, Buraidah, Kingdom of Saudi Arabia
    Saudi Med J 25:1015-9. 2004
    The aim of this study is to investigate the relationship between serum concentration of cardiac troponin T (cTnT) and other cardiac markers and ischemic heart disease (IHD) in end stage renal disease (ESRD) patients on chronic ..
  94. ncbi Long-term outcomes in hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene
    Ferdinando Pasquale
    Heart Hospital, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
    Circ Cardiovasc Genet 5:10-7. 2012
    Hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene (TNNT2) has been associated with a high risk of sudden cardiac death (SCD) and mild left ventricular hypertrophy...
  95. ncbi Serum cardiac troponin T levels as an indicator of myocardial injury in ischemic and hemorrhagic stroke patients
    Ismail Apak
    Department of Neurology, Dicle University Faculty of Medicine, Diyabakir, Turkey
    Tohoku J Exp Med 205:93-101. 2005
    ..However, the studies on cardiac troponin T (cTnT) which is more sensitive and specific to myocardium after stroke are relatively scarce...
  96. ncbi Predictive value of the high-sensitivity troponin T assay and the simplified Pulmonary Embolism Severity Index in hemodynamically stable patients with acute pulmonary embolism: a prospective validation study
    Mareike Lankeit
    Department of Cardiology and Pulmonology, University of Gottingen, Germany
    Circulation 124:2716-24. 2011
    The new, high-sensitivity troponin T (hsTnT) assay may improve risk stratification of normotensive patients with acute pulmonary embolism (PE)...
  97. ncbi Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome
    Michael Weber
    Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany
    Am Heart J 162:81-8. 2011
    ..present study, we aimed to analyze the diagnostic and prognostic potential of a newly developed high-sensitive troponin T assay and compared these results with those of a contemporary troponin T assay in 2 distinct patient cohorts, ..
  98. ncbi Novel biomarkers in early diagnosis of acute myocardial infarction compared with cardiac troponin T
    Conor J McCann
    The Heart Centre, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK
    Eur Heart J 29:2843-50. 2008
    ..To evaluate the role of novel biomarkers in early detection of acute myocardial infarction (MI) in patients admitted with acute chest pain...
  99. ncbi Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease
    B Lindahl
    Department of Cardiology, University of Uppsala, Sweden
    N Engl J Med 343:1139-47. 2000
    ..unstable coronary artery disease, there is a relation between the short-term risk of death and blood levels of troponin T (a marker of myocardial damage) and C-reactive protein and fibrinogen (markers of inflammation)...
  100. ncbi High serum cardiac troponin T concentrations in preterm infants with respiratory distress syndrome
    D Trevisanuto
    Pediatric Department, Medical School, University of Padua, Italy
    Acta Paediatr 89:1134-6. 2000
    ..On day 2 of life, cardiac troponin T (cTnT), biochemical marker of myocardial injury, was measured in 46 preterm infants (gestational age < or =32 ..
  101. pmc High-sensitivity troponin T concentrations in acute chest pain patients evaluated with cardiac computed tomography
    James L Januzzi
    Massachusetts General Hospital, Boston, MA 02114, USA
    Circulation 121:1227-34. 2010
    ..Most conventional troponin methods lack sufficient precision at this low level...

Research Grants63

  1. Right ventricular contractile dysfunction after pressure overload
    CLIFFORD RUSSELL GREYSON; Fiscal Year: 2013
    ..Agents with potential clinical utility will be identified using the isolated papillary muscle model and tested in the pig model. ..
  2. Role of troponin T isoforms in nemaline myopathy
    Jian Ping Jin; Fiscal Year: 2012
    ..The ANM allele contains a nonsense mutation in the slow skeletal muscle troponin T (TnT) gene (TNNT1), which results in truncation of the TnT protein at amino acid 179...
  3. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    ..In vitro studies have shown that most FHC-linked mutations in sarcomeric proteins (e.g., troponin T, troponin I, tropomyosin) increase myofilament Ca2+ sensitivity...
  4. Epidemiologic Study of Sick Sinus Syndrome
    Alvaro Alonso; Fiscal Year: 2012
    ..Biomarkers of interest include: C-reactive protein, NT-proBNP, and troponin T. SSS incident events will be identified from hospitalization discharge codes and Medicare (from the Center for ..
  5. Randomized trial of inhaled nitric oxide to treat acute pulmonary embolism
    Jeffrey A Kline; Fiscal Year: 2013
    ..Clinical efficacy will be defined as normal RV size, systolic function on echocardiogram and viability by serum troponin T <14 pg/mL. The basic science study tests two translational and mechanistic questions. 1...
  6. Protein intake, nutrition and cardiovascular disease in stage V CKD
    Srinivasan Beddhu; Fiscal Year: 2011
    ..Arterial stiffness (aortic pulse wave velocity) and myocardial injury (serum cardiac troponin T). The study population will be a prospective cohort of 210 HD patients recruited at Utah and Northern California...
  7. Macronutrient Regulation of Alternative Pre-mRNA Splicing
    Scot R Kimball; Fiscal Year: 2013
    ..a novel and evolutionarily conserved homeostatic response wherein alternative splicing of the pre-mRNA encoding troponin T, a protein that affects muscle force production, is tightly regulated in response to changes in body weight...
  8. The Role of the Proteasome in Troponin related Cardiomyopathies
    ALDRIN VERNO GOMES; Fiscal Year: 2013
    ..Mutations in cardiac troponin T (cTnT) are responsible for ~7% of all familial hypertrophic cardiomyopathy (FHC) cases...
  9. The Regulation of Sarcomeric Function by Tropomyosin
    David F Wieczorek; Fiscal Year: 2010
    ..Tropomyosin (TM) plays an essential regulatory role in the sarcomere through its binding to actin and the troponin T (TnT) complex...
  10. The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle C
    Jose Renato Pinto; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The cardiac troponin complex (CTn) is made up of cardiac troponin T (CTnT), that attaches the complex to the thin filament;cardiac troponin I (CTnI), involved in the inhibition of muscle contraction ..
  11. The role of Raf-MEK signaling in the pathogenesis of hypertrophic cardiomyopathy
    JASON BECKER; Fiscal Year: 2013
    ..We recently developed a zebrafish model of a human hypertrophic cardiomyopathy mutation in cardiac Troponin T. A comparison between our zebrafish model and a mouse model of HCM, discovered that the cardiac natriuretic ..
  12. Proteolytic Regulation of Troponin T &Cardiac Function
    Jian Ping Jin; Fiscal Year: 2013
    ..by Ca2+ through the troponin complex that consists of three protein subunits: troponin C, troponin I, and troponin T (TnT)...
  13. Tropin T and Excitation-Contraction Coupling in Aging Skeletal Muscle
    Osvaldo Delbono; Fiscal Year: 2013
    ..However, the mechanism leading to impaired Cav1.1 transcription with aging and its treatment is unknown. Troponin T (TnT) is known to mediate the interaction between the Tn complex and tropomyosin (Tm) in the myoplasm, which is ..
  14. The Role of Cardiomyopathic Troponin C Mutations in Skeletal and Cardiac Muscle C
    Jose Renato Pinto; Fiscal Year: 2013
    Project Summary The cardiac troponin complex (CTn) is made up of cardiac troponin T (CTnT), that attaches the complex to the thin filament;cardiac troponin I (CTnI), involved in the inhibition of muscle contraction and cardiac/slow ..
  15. Novel Biomarkers in Cardiac Surgery to Detect Acute Kidney Injury
    Chirag R Parikh; Fiscal Year: 2013
    ..Aim 2: To construct a multi-marker biomarker panel to improve risk prediction of outcomes in adults and children. ..
  16. Mechanistic Understanding of Troponin T Role in Cardiac Thin Filament Activation
    Murali Chandra; Fiscal Year: 2012
    ..on coordinated interactions among contractile regulatory pro- teins, which include cardiac troponin C (cTnC), troponin T (cTnT), troponin I (cTnI), and tropomyosin (Tm)...
  17. Role of co-chaperone, BAG3, in muscle degeneration under physiological stress
    Shinichi Takayama; Fiscal Year: 2010
    ..deficient muscle, accumulation of ubiquitinated protein, upregulation of proteasome subunit and degradation of troponin T has been observed. Ring finger type ubiquitin ligase, Siah family protein directly interact to BAG3 protein...
  18. Deciphering how tropomyosin regulates the actin filament
    SARAH ELLEN HITCHCOCK-DEGREGORI; Fiscal Year: 2013
    ..A bioinformatics analysis may explain why certain invertebrate tropomyosins are highly allergenic. There is the potential to develop therapeutic peptides to treat diseases involving this class of proteins. ..
  19. Macronutrient Regulation of Alternative Pre-mRNA Splicing
    Scot R Kimball; Fiscal Year: 2012
    ..a novel and evolutionarily conserved homeostatic response wherein alternative splicing of the pre-mRNA encoding troponin T, a gene that affects muscle force production, is tightly regulated in response to changes in body weight...
  20. Electrical Biophysical Forces Impact Cardiac Morphogenesis
    Neil C Chi; Fiscal Year: 2013
    ..which displays nonbeating, but electrically conducting hearts due to a mutation in the sarcomeric gene, cardiac troponin T, and discovered that electrical conduction exclusive of contractile and hemodynamic forces can directly ..
  21. High sensitivity Troponin T as a novel predictor of cardiovascular events
    ALEXIS LYNN BEATTY; Fiscal Year: 2012
    ..This study proposes to evaluate the relationship between high-sensitivity cardiac Troponin T (hs-cTnT) and cardiovascular outcomes in subjects from the Heart and Soul Study, a longitudinal cohort study of ..
  22. Heart-Brain Interactions In Human Acute Ischemic Stroke
    Hakan Ay; Fiscal Year: 2013
    ....
  23. Elucidating Pathways of Vascular Dysfunction and Myocardial Injury in ESRD
    Ruth Dubin; Fiscal Year: 2013
    ..High-sensitivity Troponin T, an extremely sensitive measure of chronic myocardial injury, is a strong, dose-dependent predictor for ..
  24. Systolic &diastolic dysfunction in heart failure and preserved ejection fraction
    Amil M Shah; Fiscal Year: 2013
    ..of systolic dysfunction with soluble biomarkers of myocardial stress (NT-pro-BNP) and injury (high sensitivity troponin T) to develop parsimonious risk prediction models for incident HFpEF and for adverse outcomes in patients with ..
  25. Structural Mechanisms Modulating Contraction in Normal and Diseased Heart
    Paul R Rosevear; Fiscal Year: 2010
    ..Cardiac troponin (cTn) is the calcium sensitive switch consisting of troponin C (cTnC), troponin I (cTnl), and troponin T (cTnT)...
  26. hiPS Derived Cardiomyocyte Assay for Screening Toxicant Differentiation Effects
    Bradley H Garcia; Fiscal Year: 2013
    ..by staining for brachyury, and to monitor differentiation efficiency and yield by staining for cardiac Troponin T and cardiac Troponin I...
  27. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..within the scar will include analysis for the Y chromosome (evidence of successful transplantation), cardiac troponin T, alpha actinin, tropomyosin, myosin heavy chain alpha and phospholamban, which will confirm that transplanted ..
  28. MECHANISM OF MIS-SPLICING IN MYOTONIC DYSTROPHY 1
    MUGE KUYUMCU MARTINEZ; Fiscal Year: 2007
    ..CUG-BP1 regulates alternative splicing of cardiac troponin T (cTNT), insulin receptor (IR) and chloride channel (CIC-1) pre-mRNAs that are mis-spliced in DM1 striated muscle...
  29. FHC Tn Mutations: Functional Consequences & Mechanisms
    James Potter; Fiscal Year: 2005
    ..myosin heavy chain (MHC) mutations, in general, have a higher level of cardiac hypertrophy, those with cardiac Troponin T (CTnT) and some of the reported Troponin I (CTnI) mutations have less hypertrophy and a higher incidence of ..
  30. Molecular Epidemiology of Dilated Cardiomyopath
    Luisa Mestroni; Fiscal Year: 2005
    ..have reported mutations in cardiac actin, delta-sarcoglycan, desmin, tafazzin, beta-myosin heavy chain and troponin T leading to FDC...
  31. Myofilament Protein Isoforms in Neuromuscular Reflex
    Jian Ping Jin; Fiscal Year: 2005
    ..in fiber type-specific myofilament protein isoforms, especially the actin filament-associated regulatory protein troponin T (TnT), in intrafusal fibers may play a role in the pathophysiology of muscle contracture...
  32. DEVELOPING HEART--BIOPHYSICAL ASPECTS
    Page Anderson; Fiscal Year: 1999
    ..Isoform expression of the L-type calcium channel alpha1 subunit and of troponin T, two proteins central to excitation-contraction coupling and the development acquisition of the sarcoplasmic ..
  33. MYOSIN CROSSBRIDGE FUNCTION IN HUMAN HEART FAILURE
    Norman Alpert; Fiscal Year: 1999
    ..the alteration in cross-bridge function found in failing hearts is an isoform shift in the thin filament protein troponin T (TnT) where there is a shift from the adult isoform, TnT1, to the fetal isoform, TnT2...
  34. ALTERNATIVE SPLICING OF THE CARDIAC TROPONIN T GENE
    Steven Lipshultz; Fiscal Year: 1990
    ..This analysis will concentrate on the elucidation of the structure of the mammalian cardiac troponin T (TnT) gene and its regulation during development, in response to hormone stimulation and to work overload ..
  35. ELECTROPHYSIOLOGY OF TRANSGENIC CARDIOMYOPATHIC MICE
    Charles Berul; Fiscal Year: 2001
    ..The second mouse line will have a disruption in the gene encoding the cardiac troponin T protein, which in humans produces HCM characterized by minimal hypertrophy but a high frequency of sudden death...
  36. REGULATION OF CARDIAC CROSS-BRIDGES BY TROPONIN T
    SCOTT BUCK; Fiscal Year: 2004
    ..Of the thin filament regulatory proteins, troponin T (TnT), tropomyosin, and troponin I undergo normal developmental isoform switching in heart...
  37. CARDIAC MUSCLE--MOLECULAR MECHANISMS OF REGULATION
    JOHN PUTKEY; Fiscal Year: 2000
    ..C (TnC) is the Ca2+ receptor in striated muscle which transfers the Ca2+ signal to troponin I (TnI), and then to troponin T and tropomyosin to ultimately modulate the population of productive myosin crossbridges...
  38. TROPONIN T AND THE REGULATION OF CONTRACTION
    James Potter; Fiscal Year: 2002
    DESCRIPTION (application abstract): "Troponin T (TnT) is one of three proteins (including TnI and TnC) that form the troponin complex (Tn), which regulates skeletal muscle contraction...
  39. Novel MPO-derived plasma lipids as predictors of major adverse coronary events
    David Ford; Fiscal Year: 2009
    ..new biomarkers to that of other biomarkers including C-reactive protein, MPO, chlorotyrosine, nitrotyrosine and troponin T that have previously been quantified in these specimens...
  40. MUSCLE CHEMOMECHANICAL TRANSDUCTION AND ITS REGULATION
    Earl Homsher; Fiscal Year: 2007
    ..of the interaction between the contractile proteins myosin and actin Point, missense, and deletion mutations in troponin T and tropomyosin produce hypertrophic cardiomyopahties and alter cardiac muscle isometnc force, shortening ..
  41. CONTRACTILE PROTEIN EXPRESSION IN FAILING HUMAN HEART
    Michael Bristow; Fiscal Year: 2002
    ..been detected by our group and others in the mRNA and/or protein expression of MyHC, myosin light chains, and troponin T isoforms...
  42. INTERACTIONS OF SKELETAL MUSCLE REGULATORY PROTEINS
    John Collins; Fiscal Year: 1999
    ..the Ca2+-binding troponin C (TnC), the inhibitory troponin I (TnI), actin, and the tropomyosin-binding protein troponin T (TnT)...
  43. The Function of Slow Skeletal TnT in Muscle Contraction
    James Potter; Fiscal Year: 2009
    ..is to determine the molecular mechanisms involved in the regulation of slow skeletal muscle contraction by troponin T (TnT) and to determine what regions of TnT are important for its physiological function...
  44. CELL-MATRIX INTERACTIONS IN LIMB DEVELOPMENT
    Thomas Linsenmayer; Fiscal Year: 2003
    ..Dr. Sarkar's project will examine the roles of developmentally-expressed isoforms of troponin T, a key component of the Ca++ regulatory myofibrillar protein complex of skeletal muscle...
  45. Mechanism of Calcium Regulation in Striated Muscle
    Terence Tao; Fiscal Year: 2007
    ..3) To determine the functional role of troponin T in thin filament regulation...
  46. Mechanisms of Tropomyosin Induced Hypertrophy
    David Wieczorek; Fiscal Year: 2006
    ..The Specific Aims of this proposal are: (1) To address how TM mutations in non-troponin T binding regions lead to cardiac hypertrophy; the focus of Specific Aim 1 is to develop mouse models encoding ..
  47. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
    ..We previously show that the transgene expression driven by rat cardiac troponin T (cTnT) proximal promoter is faithfully recapitulated the endogenous cTnT expression throughout the embryonic ..
  48. MOLECULAR STUDY OF CARDIOGENESIS
    Charles Ordahl; Fiscal Year: 2002
    ..interactions between two distinct regulatory domains that control cardiac-specific transcription of the cardiac troponin T gene (cTNT)...
  49. REGULATION OF CONTRACTION IN MUSCLE AND NONMUSCLE CELLS
    Sarah Hitchcock DeGregori; Fiscal Year: 2006
    ..and dynamics in solution of important functional domains of TM, complexes with the TM binding domains of troponin T (TnT), and a region of myosin proposed to be important for mechanochemical function...
  50. MOLECULAR MECHANISM OF REGULATION OF CONTRACTION
    Sarah Hitchcock DeGregori; Fiscal Year: 2000
    ..Mutations in tropomyosin and troponin T have been found in patients with familial hypertrophic cardiomyopathy...
  51. CARDIAC TROPONIN T MUTATIONS AND HEART FUNCTION
    Amy Sehnert; Fiscal Year: 2003
    ..The proposed research plan specifically addresses the affect of cardiac troponin T (cTnT) mutations on cardiac contractility...
  52. INTEGRATION OF AAV2 GENOME TO MUSCLE-SPECIFIC DNA REGION
    RALPH LINDEN; Fiscal Year: 2005
    ..We have found that the gene encoding the slow skeletal muscle troponin T (TNNTI) is located Ca...
  53. TRANSCRIPTION OF MUSCLE-SPECIFIC GENES IN MYOGENESIS
    Charles Ordahl; Fiscal Year: 1992
    ..We have characterized an embryo specific muscle gene, the gene encoding cardiac troponin T (cTNT)...
  54. Proteolytic modification of cardiac troponin T & function
    Kakoli Parai; Fiscal Year: 2007
    ..By using the transgenic mouse heart as an integrated experimental system, the results will contribute to the understanding of cardiac muscle contraction and adaptation in ischemic heart disease. [unreadable] [unreadable] [unreadable]..
  55. CARDIAC CONTRACTILE PROTEIN COOPERATIVITY
    LARRY TOBACMAN; Fiscal Year: 1991
    ..2) The N-terminal region of troponin T is highly regulated by alternative mRNA processing...
  56. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    We hypothesize that the analytical and clinical validation of cardiac troponin (cTnl) and cardiac troponin T (cTnT) will enable the establishment of reference ranges in a healthy population to be used as cutoff levels for the sensitive ..
  57. HAART Associated Cardiotoxicity in HIV-Infected Children
    Steven Lipshultz; Fiscal Year: 2008
    ..The findings will help determine the need for cardiovascular follow-up, prevention and therapeutic trials. ..
  58. CARDIAC RISK FACTORS IN PEDIATRIC CANCER SURVIVORS
    Steven Lipshultz; Fiscal Year: 2002
    ..If the hypotheses are true, this should enable more rational recommendations for preventive cardiology in long-term survivors to be made and to standardize care and management for this population. ..
  59. Cardiovascular Status of HAART-Exposed Infants/Children
    Steven Lipshultz; Fiscal Year: 2006
    ..and p2C2 HIV seroreverter cohorts to determine how left ventricular (LV) structure and function, serum cardiac troponin T (cTnT), serum pro brain natriuretic peptide (proBNP), and serum high sensitivity C reactive protein (hsCRP) are ..
  60. Primary Cardiomyopathies in Children: Research Directions & Strategies
    Steven Lipshultz; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  61. Phase 3 stem cell transplant for light chain amyloidosis
    Morie A Gertz; Fiscal Year: 2011
    ..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
  62. PEDIATRIC CARDIOMYOPATHY REGISTRY
    Steven Lipshultz; Fiscal Year: 2009
    ..These studies will dramatically increase our understanding of pediatric cardiomyopathy, suggest new areas of research and improved patient management. ..
  63. Genetic Mechanisms of Anthracycline Cardiotoxicity in Pediatric Cancer Survivors
    Steven Lipshultz; Fiscal Year: 2009
    ..If the HFE mutations are related to increased cardiotoxicity of anthracyclines. This study will elucidate the molecular mechanisms of anthracycline cardiotoxicity in pediatric ALL cancer survivors. ..