vimentin

Summary

Summary: An intermediate filament protein found in most differentiating cells, in cells grown in tissue culture, and in certain fully differentiated cells. Its insolubility suggests that it serves a structural function in the cytoplasm. MW 52,000.

Top Publications

  1. pmc Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
    Melissa G Mendez
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    FASEB J 24:1838-51. 2010
  2. pmc Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
    Marie Schoumacher
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Paris, Cedex 05, France
    J Cell Biol 189:541-56. 2010
  3. ncbi Novel functions of vimentin in cell adhesion, migration, and signaling
    Johanna Ivaska
    VTT Medical Biotechnology, Itäinen Pitkäkatu 4C, FI 20520 Turku, Finland
    Exp Cell Res 313:2050-62. 2007
  4. ncbi Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo
    Maria I Kokkinos
    Department of Surgery, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    Cells Tissues Organs 185:191-203. 2007
  5. pmc Vimentin in cancer and its potential as a molecular target for cancer therapy
    Arun Satelli
    Department of Pediatrics, Unit 853, The University of Texas MD Anderson Cancer Center, 1515 Holocombe Blvd, Houston, TX 77030, USA
    Cell Mol Life Sci 68:3033-46. 2011
  6. doi Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
    K Vuoriluoto
    Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland
    Oncogene 30:1436-48. 2011
  7. doi Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin
    Jin Feng Huang
    The Department of Medical Genetics, Second Military Medical University, Shanghai, China
    Hepatology 57:1882-92. 2013
  8. pmc Vimentin intermediate filaments modulate the motility of mitochondria
    Oxana E Nekrasova
    Group of Cell Biology, Institute of Protein Research, Russian Academy of Sciences, Moscow 119988, Russia
    Mol Biol Cell 22:2282-9. 2011
  9. pmc Vimentin organization modulates the formation of lamellipodia
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 22:1274-89. 2011
  10. doi Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma
    Min A Kim
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Histopathology 54:442-51. 2009

Detail Information

Publications379 found, 100 shown here

  1. pmc Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
    Melissa G Mendez
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    FASEB J 24:1838-51. 2010
    b>Vimentin is used widely as a marker of the epithelial to mesenchymal transitions (EMTs) that take place during embryogenesis and metastasis, yet the functional implications of the expression of this type III intermediate filament (IF) ..
  2. pmc Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
    Marie Schoumacher
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Paris, Cedex 05, France
    J Cell Biol 189:541-56. 2010
    ..Moreover, intact microtubules and vimentin intermediate filament networks are required for further growth...
  3. ncbi Novel functions of vimentin in cell adhesion, migration, and signaling
    Johanna Ivaska
    VTT Medical Biotechnology, Itäinen Pitkäkatu 4C, FI 20520 Turku, Finland
    Exp Cell Res 313:2050-62. 2007
    b>Vimentin is the major intermediate filament (IF) protein of mesenchymal cells...
  4. ncbi Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo
    Maria I Kokkinos
    Department of Surgery, St Vincent s Hospital, University of Melbourne, Melbourne, Australia
    Cells Tissues Organs 185:191-203. 2007
    ..filament status changes from a keratin-rich network which connects to adherens junctions and hemidesmosomes, to a vimentin-rich network connecting to focal adhesions...
  5. pmc Vimentin in cancer and its potential as a molecular target for cancer therapy
    Arun Satelli
    Department of Pediatrics, Unit 853, The University of Texas MD Anderson Cancer Center, 1515 Holocombe Blvd, Houston, TX 77030, USA
    Cell Mol Life Sci 68:3033-46. 2011
    b>Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress...
  6. doi Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
    K Vuoriluoto
    Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland
    Oncogene 30:1436-48. 2011
    ..The intermediate filament protein vimentin is an important marker of EMT and a requisite regulator of mesenchymal cell migration...
  7. doi Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin
    Jin Feng Huang
    The Department of Medical Genetics, Second Military Medical University, Shanghai, China
    Hepatology 57:1882-92. 2013
    ..LncRNA-Dreh could combine with the intermediate filament protein vimentin and repress its expression, and thus further change the normal cytoskeleton structure to inhibit tumor metastasis...
  8. pmc Vimentin intermediate filaments modulate the motility of mitochondria
    Oxana E Nekrasova
    Group of Cell Biology, Institute of Protein Research, Russian Academy of Sciences, Moscow 119988, Russia
    Mol Biol Cell 22:2282-9. 2011
    Interactions with vimentin intermediate filaments (VimIFs) affect the motility, distribution, and anchorage of mitochondria...
  9. pmc Vimentin organization modulates the formation of lamellipodia
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 22:1274-89. 2011
    b>Vimentin intermediate filaments (VIF) extend throughout the rear and perinuclear regions of migrating fibroblasts, but only nonfilamentous vimentin particles are present in lamellipodial regions...
  10. doi Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma
    Min A Kim
    Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
    Histopathology 54:442-51. 2009
    ..EMT is known to be involved in the progression and metastasis of various cancers. The aim was to evaluate the expression of EMT-related proteins in gastric carcinoma (GC)...
  11. doi NF-kappaB and epithelial to mesenchymal transition of cancer
    Chengyin Min
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118 2394, USA
    J Cell Biochem 104:733-44. 2008
    ..Overall, NF-kappaB is identified as a key target in prevention and in the treatment of invasive carcinomas...
  12. doi Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways
    Sze Wan Shan
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto M4N 3M5, Canada
    J Cell Sci 126:1517-30. 2013
    ..In contrast, the passenger strand miR-17-3p repressed expression of vimentin, an intermediate filament with the ability to modulate metabolism, and GalNT7, an enzyme that regulates ..
  13. pmc Telocytes in human epicardium
    L M Popescu
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
    J Cell Mol Med 14:2085-93. 2010
    ..Human autopsy hearts from 10 adults and 15 foetuses were used for conventional IHC for c-kit/CD117, CD34, vimentin, S-100, τ, Neurokinin 1, as well as using laser confocal microscopy...
  14. ncbi Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA
    Int Rev Cytol 230:263-90. 2003
    ..detachment, a "mechanical" injury to the retina, GFAP, and another intermediate filament protein, vimentin, dramatically increase in Müller cells...
  15. pmc Tumor suppressive microRNA‑138 contributes to cell migration and invasion through its targeting of vimentin in renal cell carcinoma
    Takeshi Yamasaki
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
    Int J Oncol 41:805-17. 2012
    ..analysis (miR‑138 transfectants and RCC clinical specimens) and TargetScan database studies showed that vimentin (VIM) is a promising candidate target gene of miR‑138...
  16. doi Aberrant expression of nuclear vimentin and related epithelial-mesenchymal transition markers in nasopharyngeal carcinoma
    Weiren Luo
    Cancer Research Institute, Southern Medical University, Guangzhou, Guangdong Province, People s Republic of China
    Int J Cancer 131:1863-73. 2012
    Expression of vimentin and the epithelial to mesenchymal transition (EMT) markers E-cadherin, β-catenin is essential for the progression of various human cancers...
  17. ncbi Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2
    Christine L Chaffer
    Bernard O Brien Institute of Microsurgery, The University of Melbourne, St Vincent s Hospital, Australia
    Cancer Res 66:11271-8. 2006
    ..This model is the first to specifically model steps of the latter part of the metastatic cascade in isogenic cell lines, and confirms the suspected role of MET in secondary tumor growth...
  18. pmc The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer
    S Al-Saad
    Institute of Medical Biology, University of Tromso Norway, Tromso, Norway
    Br J Cancer 99:1476-83. 2008
    b>Vimentin, nuclear factor-kappaB (NF-kappaB) p105, fascin, E-cadherin, TGF-beta, Par6 and atypical PKC are molecular markers that play an important role in cell differentiation...
  19. ncbi Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis
    Y Byun
    Center for Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Cell Death Differ 8:443-50. 2001
    ..recently developed to identify cDNAs encoding caspase substrates, we isolated the intermediate filament protein vimentin as a caspase substrate...
  20. doi Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome
    Lai Kui Liu
    Department of Oral Pathology, College of Stomatology, Nanjing Medical University, Jiangsu 210029, China
    Mod Pathol 23:213-24. 2010
    ..Using quantitative immunohistochemistry, we examined the expression of vimentin, E-cadherin, and beta-catenin in 83 oral squamous cell carcinoma patients, and the relationships between the ..
  21. ncbi Intermediate filament protein partnership in astrocytes
    C Eliasson
    Department of Medical Biochemistry, University of Gothenburg, SE 405 30 Gothenburg, Sweden
    J Biol Chem 274:23996-4006. 1999
    ..Astrocytes may express three types of intermediate filament proteins: glial fibrillary acidic protein (GFAP), vimentin, and nestin...
  22. ncbi The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
    ..of the epithelial markers desmoplakin, E-cadherin, and beta-catenin and up-regulation of the mesenchymal marker vimentin. The cells lost epithelial cell morphology and acquired fibroblast-like properties...
  23. pmc Introducing intermediate filaments: from discovery to disease
    John E Eriksson
    Department of Biology, Abo Akademi University, Turku, Finland
    J Clin Invest 119:1763-71. 2009
    ..e., maintenance of structural and mechanical integrity of cells and tissues. However, many disease conditions seem to link to the nonmechanical functions of IFs, many of which have been defined only in the past few years...
  24. ncbi Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature
    Judy R van Beijnum
    Angiogenesis Laboratory, Department of Pathology, University Hospital Maastricht, PO Box 5800, 6202AZ Maastricht, The Netherlands
    Blood 108:2339-48. 2006
    ..Antibody targeting of 4 cell-surface-expressed or secreted products (vimentin, CD59, HMGB1, IGFBP7) inhibited angiogenesis in vitro and in vivo...
  25. ncbi Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration
    Ulrika Wilhelmsson
    Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, SE 405 30 Goteborg, Sweden
    J Neurosci 24:5016-21. 2004
    ..found that reactive astrocytes devoid of the intermediate filament proteins glial fibrillary acidic protein and vimentin (GFAP-/-Vim-/-), and consequently lacking intermediate filaments (Colucci-Guyon et al., 1994; Pekny et al...
  26. pmc The intermediate filament vimentin mediates microRNA miR-378 function in cellular self-renewal by regulating the expression of the Sox2 transcription factor
    Zhaoqun Deng
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada
    J Biol Chem 288:319-31. 2013
    ..We also observed opposite levels of vimentin in the cancer cell lines and human breast carcinoma specimens...
  27. doi Epithelial to mesenchymal transition (EMT) biomarkers--E-cadherin, beta-catenin, APC and Vimentin--in oral squamous cell carcinogenesis and transformation
    S Y Chaw
    The University of Queensland, School of Dentistry, 200 Turbot Street, Brisbane, Queensland 4000, Australia
    Oral Oncol 48:997-1006. 2012
    To investigate immunohistochemical (IHC) analysis of E-cadherin, β-catenin, APC and Vimentin for prediction of oral malignant transformation.
  28. pmc Vimentin rearrangement during African swine fever virus infection involves retrograde transport along microtubules and phosphorylation of vimentin by calcium calmodulin kinase II
    Sandra Stefanovic
    Division of Immunology, Pirbright Laboratories, Institute for Animal Health, Surrey Ash Road, Woking, Surrey GU24 ONF, United Kingdom
    J Virol 79:11766-75. 2005
    African swine fever virus (ASFV) infection leads to rearrangement of vimentin into a cage surrounding virus factories...
  29. pmc Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophage phagocytic activities
    Amanda E Starr
    Centre for Blood Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 287:13382-95. 2012
    ..b>Vimentin, cystatin C, galectin-1, IGFBP-7, and secreted protein, acidic and rich in cysteine (SPARC) were among those ..
  30. ncbi Regulation of vimentin by SIP1 in human epithelial breast tumor cells
    S Bindels
    Laboratory of Tumor and Developmental Biology, Center for Biomedical Integrated Genoproteomics, University of Liege, CHU Sart Tilman, Liege, Belgium
    Oncogene 25:4975-85. 2006
    The expression of Smad interacting protein-1 (SIP1; ZEB2) and the de novo expression of vimentin are frequently involved in epithelial-to-mesenchymal transitions (EMTs) under both normal and pathological conditions...
  31. doi Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain
    Sara Ekmark-Lewén
    Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    Restor Neurol Neurosci 28:311-21. 2010
    ..The aims for this study were to compare the temporal and spatial expression pattern of vimentin- and glial fibrillary acidic protein (GFAP) in a weight drop model of mild cerebral contusion injury in the rat...
  32. pmc High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion
    Laura Lehtinen
    Medical Biotechnology, VTT Technical Research Centre of Finland and Turku Centre for Biotechnology, University of Turku, Turku, Finland
    Oncotarget 4:48-63. 2013
    b>Vimentin is an intermediate filament protein, with a key role in the epithelial to mesenchymal transition as well as cell invasion, and it is often upregulated during cancer progression...
  33. pmc TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells
    G M Marshall
    Children s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia
    Oncogene 29:6172-83. 2010
    ..TRIM16 bound directly to cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells...
  34. ncbi Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury
    Jun Zou
    Department of Structural Pathology, Institute of Nephrology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Virchows Arch 448:485-92. 2006
    ..To gain insight into the role of IF proteins in podocytes, we investigated the expression of nestin, vimentin, and desmin in puromycin aminonucleoside (PAN) nephrosis...
  35. pmc TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members
    Yongzhong Wu
    Department of Biochemistry and the Massey Cancer Center, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1773:427-39. 2007
    b>Vimentin exhibits a complex pattern of developmental and tissue-specific expression regulated by such growth factors as TGFbeta1, PDGF, FGF, EGF and cytokines...
  36. doi Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility
    Rachel J Paccione
    Philips Institute, Virginia Commonwealth University, Richmond, Virginia, USA
    Mol Cancer Ther 7:2894-903. 2008
    ..In the current study, we have investigated the role of vimentin in proliferation and motility...
  37. ncbi The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression
    Yongzhong Wu
    The Department of Biochemistry and the Massey Cancer Center, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, VA 23298 0614, USA
    Genes Cells 12:905-18. 2007
    b>Vimentin, a member of the intermediate filament (IF) protein family, exhibits a complex pattern of tissue- and developmental-specific expression...
  38. doi Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth
    Su Yeon Shim
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary T2N 4N1, Canada
    J Biol Chem 283:12232-40. 2008
    ..We isolated a novel Ndel1 molecular complex composed of the IF vimentin, the molecular motor dynein, the lissencephaly protein Lis1, and the cis-Golgi-associated protein alphaCOP...
  39. pmc The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 165:577-92. 2004
    ..immunoprecipitation, and double-immunolabeling analysis showed that the 14-3-3 protein interacts with both vimentin and glial fibrillary acidic protein in cultured human astrocytes...
  40. doi Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    Natalia Wegner
    The Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Immunol Rev 233:34-54. 2010
    ..Four citrullinated antigens, fibrinogen, vimentin, collagen type II, and alpha-enolase, are now well established, with others awaiting further characterization...
  41. pmc Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies
    Guy Lahat
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e10105. 2010
    b>Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly in ..
  42. ncbi N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
    Sanae Nakajima
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 10:4125-33. 2004
    ..The purpose of the study presented here was to investigate whether a gain in N-cadherin in pancreatic cancer is involved in the process of metastasis via EMT and whether its expression is affected by growth factors...
  43. pmc The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin
    Paola Bargagna-Mohan
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536, USA
    Chem Biol 14:623-34. 2007
    ..Here, we show that WFA binds to the intermediate filament (IF) protein, vimentin, by covalently modifying its cysteine residue, which is present in the highly conserved alpha-helical coiled coil ..
  44. pmc Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages
    E R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Ann Rheum Dis 63:373-81. 2004
    ..Peptidylcitrulline can be generated by post-translational conversion of arginine residues. This process, citrullination, is catalysed by a group of calcium dependent peptidylarginine deiminase (PAD) enzymes...
  45. ncbi Vimentin is secreted by activated macrophages
    Nirit Mor-Vaknin
    Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, MI 48109 0640, USA
    Nat Cell Biol 5:59-63. 2003
    b>Vimentin is a widely expressed intermediate filament protein thought to be involved mainly in structural processes, such as wound healing. We now demonstrate that activated human macrophages secrete vimentin into the extracellular space...
  46. pmc Quantitative evaluation of vimentin expression in tumour stroma of colorectal cancer
    C Y Ngan
    Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Br J Cancer 96:986-92. 2007
    Recent studies have identified vimentin, a type III intermediate filament, among genes differentially expressed in tumours with more invasive features, suggesting an association between vimentin and tumour progression...
  47. pmc Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    Ulrike Harre
    Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
    J Clin Invest 122:1791-802. 2012
    ..human osteoclasts expressed enzymes eliciting protein citrullination, and specific N-terminal citrullination of vimentin was induced during osteoclast differentiation...
  48. ncbi Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts
    B Eckes
    Department of Dermatology, University of Cologne, Federal Republic of Germany
    J Cell Sci 111:1897-907. 1998
    Loss of a vimentin network due to gene disruption created viable mice that did not differ overtly from wild-type littermates...
  49. pmc Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments
    Ram K Sihag
    Laboratory of Neurochemistry, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Bldg 49 Room 2A28, MD 20892, USA
    Exp Cell Res 313:2098-109. 2007
    ..In mitotic cells, Cdk1, Rho kinase, PAK1 and Aurora-B kinase are believed to regulate vimentin and glial fibrillary acidic protein phosphorylation in a spatio-temporal manner...
  50. pmc PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility
    Johanna Ivaska
    VTT Technical Research Centre for Finland, Medical Biotechnology and University of Turku Centre for Biotechnology, Turku, Finland
    EMBO J 24:3834-45. 2005
    ..b>Vimentin, an intermediate filament protein upregulated upon epithelial cell transformation, is shown here to be a proximal ..
  51. pmc Endoplasmic reticulum-Golgi intermediate compartment membranes and vimentin filaments participate in vaccinia virus assembly
    Cristina Risco
    Department of Macromolecular Structure, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Campus Universidad Autonoma, Madrid 28049, Spain
    J Virol 76:1839-55. 2002
    ..Moreover, the cytoskeletal vimentin intermediate filaments are found around viral factories and inside the viroplasm foci, where vimentin and the VV ..
  52. ncbi Association of Vimentin overexpression and hepatocellular carcinoma metastasis
    Liang Hu
    Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China
    Oncogene 23:298-302. 2004
    ..One interesting finding is the overexpression of Vimentin (VIM), a well-defined intermediate filament, which has been linked to a more aggressive status in various tumors...
  53. ncbi Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma
    Shona H Lang
    YCR Cancer Research Unit, University of York, Heslington, York, United Kingdom
    Prostate 52:253-63. 2002
    ..The metastatic potential of a series of prostate cell lines was analysed by measuring motility and invasiveness, and further correlated to the expression of epithelial differentiation markers...
  54. ncbi The evaluation of E-Cadherin and vimentin as biomarkers of clinical outcomes among patients with non-small cell lung cancer treated with erlotinib as second- or third-line therapy
    Frank Richardson
    OSI Pharmaceuticals LLC, 2860 Wilderness Place, Boulder, CO 80301, USA
    Anticancer Res 32:537-52. 2012
    E-Cadherin and vimentin protein expression was assessed in late stage non-small cell lung cancer tumors from the placebo controlled clinical trial, NCIC-CTG BR...
  55. pmc A novel role of vimentin filaments: binding and stabilization of collagen mRNAs
    Azariyas A Challa
    Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306, USA
    Mol Cell Biol 31:3773-89. 2011
    ..LARP6 binds the 5'SL of α1(I) and α2(I) mRNAs with high affinity. Here, we report that vimentin filaments associate with collagen mRNAs in a 5'SL- and LARP6-dependent manner and stabilize collagen mRNAs...
  56. pmc Aberrant vimentin methylation is characteristic of upper gastrointestinal pathologies
    Helen Moinova
    Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Cancer Epidemiol Biomarkers Prev 21:594-600. 2012
    We have previously established aberrant DNA methylation of vimentin exon-1 (VIM methylation) as a common epigenetic event in colon cancer and as a biomarker for detecting colon neoplasia...
  57. doi Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital, PO Box 22, 90029 Oulu, Finland
    Breast Cancer Res Treat 138:81-90. 2013
    ..g. EMT-regulating transcription factors are largely unknown. We assessed immunohistochemically vimentin (separately in in situ areas and in invasive cells) as an indicator of EMT, and also EMT-regulating transcription ..
  58. pmc PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation
    Maria Isabel Rodriguez
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    PLoS Genet 9:e1003531. 2013
    ..Proteomic analysis of endothelial cells revealed that vimentin, an intermediary filament involved in angiogenesis and a specific hallmark of EndoMT (endothelial to mesenchymal ..
  59. ncbi Detection in fecal DNA of colon cancer-specific methylation of the nonexpressed vimentin gene
    Wei Dong Chen
    Department of Medicine, Ireland Comprehensive Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA
    J Natl Cancer Inst 97:1124-32. 2005
    ..Aberrantly methylated DNA has also been proposed as a potential tumor marker. However, genes such as vimentin, which are transcriptionally silent in normal epithelium, have not until now been considered as targets for ..
  60. doi Vimentin binding is critical for infection by the virulent strain of Japanese encephalitis virus
    Jian Jong Liang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Cell Microbiol 13:1358-70. 2011
    ..One major protein bound with RP-9 and weakly with RP-2ms was identified as the intermediate filament protein vimentin. Infection of RP-9 but not that of RP-2ms was blocked by anti-vimentin antibodies and by recombinant-expressed ..
  61. doi Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients
    Cristina Raimondi
    Division of Medical Oncology, Sapienza University of Rome, Rome, Italy
    Breast Cancer Res Treat 130:449-55. 2011
    ..Samples found positive for CTCs presence (CD45-/CK+) were evaluated for the expression of ER alpha, HER2, ALDH1, vimentin, and fibronectin...
  62. doi Vimentin expression is associated with decreased survival in gastric cancer
    Sho Otsuki
    Department of Surgical Oncology, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo, Tokyo 113 8519, Japan
    Oncol Rep 25:1235-42. 2011
    ..In some cancers, expression of vimentin, a mesenchymal maker, is associated with poor survival...
  63. pmc Characterization of immune responses to cardiac self-antigens myosin and vimentin in human cardiac allograft recipients with antibody-mediated rejection and cardiac allograft vasculopathy
    Dilip S Nath
    Division of Cardiothoracic Surgery, Barnes Jewish Hospital, St Louis, Missouri, USA
    J Heart Lung Transplant 29:1277-85. 2010
    ..to mismatched human leukocyte antigen (HLA) and antibodies (Abs) to the cardiac self-antigens myosin (MYO) and vimentin (VIM) in the pathogenesis of acute antibody-mediated rejection (AMR) in the early post-transplant period (EP, <..
  64. doi Plectin interacts with the rod domain of type III intermediate filament proteins desmin and vimentin
    Bertrand Favre
    Department of Dermatology, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland
    Eur J Cell Biol 90:390-400. 2011
    ..The muscle-specific intermediate filament (IF) protein desmin, which progressively replaces vimentin during differentiation of myoblasts, is one of the important binding partners of plectin in mature muscle...
  65. pmc Vimentin inhibits ATF4-mediated osteocalcin transcription and osteoblast differentiation
    Na Lian
    Department of Medicine, Vanderbilt University Center for Bone Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 284:30518-25. 2009
    ..b>Vimentin was identified by liquid chromatography-mass spectrometry...
  66. ncbi Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts
    K Nishio
    Department of Anatomy and Cell Biology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Histochem Cell Biol 116:321-7. 2001
    ..normal young or immortalized cells growing rapidly, and the protein was identified with a cytoskeletal protein, vimentin. In fact, senescent fibroblasts contained approximately threefold more vimentin protein, and fourfold more ..
  67. doi Vimentin interacts with heterogeneous nuclear ribonucleoproteins and dengue nonstructural protein 1 and is important for viral replication and release
    Rattiyaporn Kanlaya
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 12th Floor Adulyadejvikrom Building, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand
    Mol Biosyst 6:795-806. 2010
    ..Interestingly, vimentin was a common partner for both hnRNP C1/C2 and K...
  68. doi Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin
    Hsiang Yu Chang
    Graduate Institute of Life Sciences, National Defense Medical Center and Academia Sinica, Taipei, Taiwan
    J Agric Food Chem 59:5357-63. 2011
    ..This study found specific increases in Mdm2 and vimentin rather than the coregulation of an array of EMT marker proteins in response to HGF-induced EMT in DU145 prostate ..
  69. ncbi Vimentin: the conundrum of the intermediate filament gene family
    R M Evans
    Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    Bioessays 20:79-86. 1998
    ..However, a knockout mutation of vimentin (-/-), the intermediate filament protein characteristically expressed in cells of mesenchymal origin, results in ..
  70. doi Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells
    Mingli Han
    Department of Endocrine Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
    Mol Cell Biochem 363:427-36. 2012
    ..of miR-21 induced the acquisition of EMT phenotype by activation of mesenchymal cell markers (N-cadherin, Vimentin, α-SMA) and inhibition of epithelial cell marker (E-cadherin) in MCF-7/miR-21 cells, which consistent with ..
  71. doi Involvement of the transcription factor twist in phenotype alteration through epithelial-mesenchymal transition in lung cancer cells
    Harunori Nakashima
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Mol Carcinog 51:400-10. 2012
    ..The lung cancer cell lines with high twist expression also tended to show a high vimentin/E-cadherin ratio, which was supported by a migration assay, in which high twist expression gave rise to high cell ..
  72. pmc Vimentin regulates scribble activity by protecting it from proteasomal degradation
    Dominic C Y Phua
    Epithelial Cell Biology Laboratory, Cancer and Developmental Cell Biology Division, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673, Republic of Singapore
    Mol Biol Cell 20:2841-55. 2009
    ..Scrib binds vimentin via its postsynaptic density 95/disc-large/zona occludens domains and in MDCK cells redistributes from filaments ..
  73. ncbi Vimentin function in lymphocyte adhesion and transcellular migration
    Mikko Nieminen
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, P O Box 123, FIN 20521 Turku, Finland
    Nat Cell Biol 8:156-62. 2006
    ..The initiation of this process was markedly reduced in vimentin-deficient (vim(-/-)) PBMCs and endothelial cells...
  74. doi Vimentin-mediated signalling is required for IbeA+ E. coli K1 invasion of human brain microvascular endothelial cells
    Feng Chi
    Saban Research Institute of Childrens Hospital Los Angeles, Department of Pediatrics, University of Southern California, Los Angeles, CA 90027, USA
    Biochem J 427:79-90. 2010
    ..b>Vimentin was identified as an IbeA-binding protein on the surface of HBMECs (human BMECs)...
  75. ncbi A comparison of intermediate filament markers for presumptive astroglia in the developing rat neocortex: immunostaining against nestin reveals more detail, than GFAP or vimentin
    M Kalman
    Department of Anatomy, Histology and Embryology, Semmelweis University of Medicine, Tuzoltó 58, 1094, Budapest, Hungary
    Int J Dev Neurosci 19:101-8. 2001
    ..rat cortex between the day of birth (P0) and the 18th postnatal day (P18), after immunostaining against nestin, vimentin and glial fibrillary acidic protein (GFAP)...
  76. ncbi Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells
    Marvin C Gershengorn
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 8029, USA
    Science 306:2261-4. 2004
    ....
  77. doi RCAS1, MT, and vimentin as potential markers of tumor microenvironment remodeling
    Magdalena Dutsch-Wicherek
    Department of Otolaryngology Head and Neck Surgery, Jagiellonian University, Sniadeckich 2, Krakow, Poland
    Am J Reprod Immunol 63:181-8. 2010
    ..Lastly, vimentin is a protein that would appear to be the marker for the mesenchymal transition of cells from the epithelial ..
  78. pmc Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance
    F Terzi
    INSERM U 380, Institut Cochin de Genetique Moleculaire, Paris, France
    J Clin Invest 100:1520-8. 1997
    ..Disruption, by homologous recombination, of the gene encoding vimentin, a class III intermediate filament protein mainly expressed in vascular cells, was reported to result in ..
  79. ncbi Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: correlation with histopathological parameters, hormone receptors, and oncoproteins
    N Dandachi
    Institute of Pathological Anatomy, Landeskliniken Salzburg, Salzburg, Austria
    J Pathol 193:181-9. 2001
    ..In human breast carcinomas, up-regulation of tenascin-C (TN-C) and vimentin (Vim) is frequently observed in cancer cells and correlates with increased malignancy...
  80. ncbi Antibodies to alpha B-crystallin, vimentin, and heat shock protein 70 in aqueous humor of patients with normal tension glaucoma and IgG antibody patterns against retinal antigen in aqueous humor
    Stephanie C Joachim
    Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany
    Curr Eye Res 32:501-9. 2007
    ..To show the existence of IgG antibodies against retinal antigens in aqueous humor of normal tension glaucoma patients...
  81. pmc Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung
    Ludmila Prudkin
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mod Pathol 22:668-78. 2009
    ..analyzed for immunohistochemical expression by image analysis of E-cadherin, N-cadherin, integrin-alpha v beta 6, vimentin, and matrix metalloproteinase-9. The findings were compared with the patients' clinicopathologic features...
  82. ncbi Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase
    Eran Perlson
    Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Mol Biol 364:938-44. 2006
    Cleavage fragments of de novo synthesized vimentin were recently reported to interact with phosphorylated Erk1 and Erk2 MAP kinases (pErk) in injured sciatic nerve, thus linking pErk to a signaling complex retrogradely transported on ..
  83. pmc Culture of rat endometrial telocytes
    Kota Hatta
    Division of Cardiovascular Surgery and Toronto, General Research Institute, University Health Network, Toronto, ON, Canada
    J Cell Mol Med 16:1392-6. 2012
    ..In both species, telocytes also stained positive for vimentin and connexin 43. Telopodes were observed connecting cell colonies and connecting distant cells...
  84. doi MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer
    Chun Wen Cheng
    Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan
    Breast Cancer Res Treat 134:1081-93. 2012
    ..The functional interaction between the candidate miRNA, miR-30a, and the target gene, Vim, which codes for vimentin, a protein involved in epithelial-mesenchymal transition, was examined using the luciferase reporter assay, ..
  85. ncbi C-kit immunopositive interstitial cells (Cajal-type) in human myometrium
    Sanda M Ciontea
    Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, 050474, Romania
    J Cell Mol Med 9:407-20. 2005
    ..interstitial cells in human uterus are contradictory in terms of c-kit immunoreactivity: either negative (but vimentin-positive) in pregnant myometrium, or positive, presumably in the endometrium...
  86. ncbi Vimentin-positive, c-kit-negative interstitial cells in human and rat uterus: a role in pacemaking?
    R A Duquette
    Department of Physiology, The University of Liverpool, Liverpool, United Kingdom
    Biol Reprod 72:276-83. 2005
    ..They stained positive for the intermediate filament, vimentin, a marker for cells of mesenchymal origin but not differentiated myocytes...
  87. ncbi Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion
    Lorna McInroy
    Centre for Stem Cell Research and Regenerative Medicine, School of Biological and Biomedical Sciences, University of Durham, DH1 3LE Durham, UK
    Biochem Biophys Res Commun 360:109-14. 2007
    b>Vimentin is a type III Intermediate filament protein that is expressed frequently in epithelial carcinomas correlating with invasiveness and poor prognosis...
  88. ncbi Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression
    V Menet
    Institut National de la Santé et de la Recherche Médicale U336, Universite Montpellier II, F 34095 Montpellier, France
    J Neurosci 21:6147-58. 2001
    ..astrocytes play a major role in neuronal migration and neuritogenesis, and their IFs are mainly composed of vimentin. In mature differentiated astrocytes, vimentin is replaced by the IF protein glial fibrillary acidic protein (..
  89. ncbi High-resolution multi-parameter DNA flow cytometry enables detection of tumour and stromal cell subpopulations in paraffin-embedded tissues
    Willem E Corver
    Department of Pathology, Leiden University Medical Centre, The Netherlands
    J Pathol 206:233-41. 2005
    ..Cells were simultaneously stained for keratin (FITC), vimentin (R-PE), and DNA (PI) before flow cytometric analysis...
  90. pmc The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton
    Melanie L Styers
    Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 15:5369-82. 2004
    ..Concomitant with these architectural changes, and similarly to AP-3-null mocha cells, fibroblasts lacking vimentin were compromised in their vesicular zinc uptake, their organellar pH, and their total and surface content of AP-3 ..
  91. pmc Forced unfolding of proteins within cells
    Colin P Johnson
    Biophysical Engineering Lab, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 317:663-6. 2007
    ..Within mesenchymal stem cells-as a prototypical adherent cell-nonmuscle myosin IIA and vimentin are just two of the cytoskeletal proteins identified that show differential labeling in tensed versus drug-..
  92. ncbi Impaired wound healing in embryonic and adult mice lacking vimentin
    B Eckes
    Department of Dermatology, University of Cologne, Koln, Germany
    J Cell Sci 113:2455-62. 2000
    It is generally assumed that the vimentin intermediate filament network present in most mesenchymally-derived cells is in part responsible for the strength and integrity of these cells, and necessary for any tissue movements that require ..
  93. ncbi Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides
    Lena Innala
    Department of Rheumatology, Department of Clinical Immunology, and Department of Transfusion Medicine, University Hospital, Umea, Sweden
    J Rheumatol 35:1002-8. 2008
    ..To evaluate the predictive values for disease progression of various antibodies against citrullinated peptide proteins (ACPA) and their relation to PTPN22 1858C/T polymorphism and HLA-DRB1 alleles in early rheumatoid arthritis (RA)...
  94. pmc Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas
    Socorro Maria Rodriguez-Pinilla
    Laboratory of Breast and Gynaecological Cancer, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    J Clin Pathol 60:1006-12. 2007
    To determine whether basal-like phenotype and vimentin and/or laminin are related in both sporadic/familial (BRCA1 or BRCA2 mutated) tumours.
  95. doi Shear flow increases S-nitrosylation of proteins in endothelial cells
    Bin Huang
    Cardiovascular Division, Institute of Biomedical Sciences, Academia Sinica, 128 sec 2 Academia Rd NanKang, Taipei 11529, Taiwan
    Cardiovasc Res 83:536-46. 2009
    ..S-nitrosylation of endothelial proteins after shear flow treatment has not been fully explored. In this study, the CyDye switch method was utilized to examine S-nitrosylated proteins in ECs after exposure to shear flow...
  96. ncbi Gap junctions and connexin expression in human suburothelial interstitial cells
    G P Sui
    Institute of Urology, London, UK
    BJU Int 90:118-29. 2002
    ..To determine whether suburothelial interstitial cells of the human bladder express gap junctions, and if so, to establish their extent and composition, using immunocytochemistry, confocal microscopy and electron microscopy...
  97. doi Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition
    Hui Jun Zhang
    Tenth People Hospital of Tongji University, Shanghai, China
    Mol Cell Biochem 355:309-14. 2011
    ..under a phase contrast microscope, then western blotting was employed to detect the expression of E-cadherin, vimentin, and fibronectin, and finally cell motility and invasion were evaluated by cell wound-healing as well as invasion ..
  98. doi Expression of E-cadherin and vimentin correlates with metastasis formation in head and neck squamous cell carcinoma patients
    Monique M Nijkamp
    Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, The Netherlands
    Radiother Oncol 99:344-8. 2011
    ..b>Vimentin is highly expressed in mesenchymal cells and is positively correlated with increased metastasis...
  99. pmc Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins
    Katleen Van Steendam
    Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Arthritis Res Ther 12:R132. 2010
    ....
  100. ncbi The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential?
    Eberhard Korsching
    Institute of Pathology, University of Munster, Germany
    J Pathol 206:451-7. 2005
    b>Vimentin expression is a rather rare finding in invasive breast cancer, and is associated with high tumour invasiveness and chemoresistance...
  101. pmc Hierarchical structure controls nanomechanical properties of vimentin intermediate filaments
    Zhao Qin
    Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 4:e7294. 2009
    ..Here we utilize an atomistic-level model of the human vimentin dimer and tetramer to study their response to mechanical tensile stress, and describe a detailed analysis of the ..

Research Grants62

  1. Nuclear-Cytoplasmic Shuttling of Foxc2 via 14-3-3 Determines Proximal Tubule Cell
    DIANA LYNNE GOLDEN; Fiscal Year: 2012
    ..leads to repression of epithelial markers (E-cadherin and catenins) and an increase in mesenchymal markers (vimentin and [unreadable]-Sma)...
  2. Abnormal Bladder Epithelial Cell Gene Expression in BPS/IC
    SUSAN F KEAY; Fiscal Year: 2013
    ..coupled with abnormal proteoglycan and protein expression (including tight junction and adherens proteins, vimentin, and uroplakin III)...
  3. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The E. coli IbeA receptor Vimentin (Vim), in conjunction with its co-receptor PSF, plays an important role in the pathogenesis of neonatal sepsis and meningitis (NSM), which remains a major cause of ..
  4. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..increase disease severity by modulating immune response in lungs leading to presentation of a self protein like Vimentin ensuing autoreactive response. In this proposal, we have 2 aims...
  5. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    ..Nestin, Pax6, GFAP), neuronal progenitors cells and neuroblasts (TUC-4, TUJ-1, PSA-NCAM), or immature glia (Vimentin) will be used to establish the phenotype of the dividing cells...
  6. EXTRACELLULAR MATRIX IN INFLAMMATORY BOWEL DISEASE
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..when the T cell is bound to collagen, and that the pattern of serine phosphorylation on the head domain of vimentin (the key component of the intermediate filament in T cells) is similarly distinct...
  7. Diagnosis of sub-clinical cryptic group A streptococcal myonecrosis
    Amy Evelyn Bryant; Fiscal Year: 2013
    ..Two complimentary approaches will be taken. The first is a vimentin-focused approach that extends our previously published findings supporting a role for vimentin/GAS interaction in ..
  8. Regulation and Catalysis of Human Insulin Degrading Enzyme
    Wei Jen Tang; Fiscal Year: 2013
    ..IDE by dimerization, physiologically relevant cellular factors such as intermediate filament proteins, nestin and vimentin, and by posttranslational modifications such as phosphorylation and acetylation...
  9. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..Mechanistic studies will complement in vitro studies;the expression of RhoA, Rac1, Erk1, PI3K, E-cadherin, vimentin, and fibronectin will assess the effect of CEL therapy on cell migration, activation, survival, and the EMT...
  10. Repressing HIF-1: targets and mechanisms
    Nianli Sang; Fiscal Year: 2012
    ..control system (QCS) plays a central role in regulating HIF-1a stability, and this QCS involves Hsp70/Hsp90, vimentin, proteasome and microtubule function;and 2) histone deacetylase inhibitor-induced repression of HIF-1 ..
  11. Cytoskeletal Pliability within Cells under Stress: RBCs and Marrow-derived SCs
    Dennis E Discher; Fiscal Year: 2012
    ..Within mesenchymal stem cells, initial results show non-muscle myosin IIA, filamin-A, and vimentin are just a few of the cytoskeletal proteins that exhibit differential labeling in tensed versus relaxed cells...
  12. Great Lakes/New England Clinical Validation Center
    Dean E Brenner; Fiscal Year: 2013
    ..In the next grant period, the GLNE-CVC proposes to 1. To determine the performance of vimentin methylation, galectin-3 ligand, the Exact stool DNA panel, and fecal immunochemical test (FIT) for the early ..
  13. ESCHERICHIA COLI INVASION OF BRAIN ENDOTHELIAL CELLS
    Sheng He Huang; Fiscal Year: 2009
    ..coli K1 in vitro (BMEC) and in vivo (meningitis in murine neonates). Vimentin is the common receptor on BMEC and PMN surface that contributes to IbeA/E-mediated pathogenicities...
  14. SpyA, a novel S. pyogenes ADP-ribosyltransferase
    STEPHEN L MOSELEY; Fiscal Year: 2010
    ..pyogenes ADP-ribosylating toxin. SpyA transfers the ADP-ribose portion of NAD onto the cytoskeletal proteins vimentin, actin, and tropomyosin...
  15. Chronic Graft Destruction: Interplay of Allo- and Autoantibodies and Nonadherence
    Steven A Webber; Fiscal Year: 2013
    ..determine the long-term impact of DSA (preformed versus de novo) and antibodies to self-antigens (cardiac myosin, vimentin) on chronic graft function...
  16. Mechanism of Anthrax Lethal Factor Toxicity
    Usamah S Kayyali; Fiscal Year: 2012
    ..the endothelial permeability barrier through strengthening adhesive forces mediated by actin stress fiber and vimentin intermediate filament network formation...
  17. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ..of epithelial markers such as E-cadherin, along with a concomitant upregulation of the mesenchymal markers vimentin and fibronectin as well as inducing the development or a scattering phenotype consistent with the loss of E-..
  18. Regulation of Type I Collagen in Hepatic Fibrosis
    Branko Stefanovic; Fiscal Year: 2012
    ..5'stem-loop interacting proteins, RBM14, nucleolin, vimentin and RNA helicase A, have been identified by proteomics approach...
  19. Modulation of junctional signaling by BVES in colorectal carcinoma
    Christopher S Williams; Fiscal Year: 2013
    ..the line with conversion to epithelial morphology and increased expression of cytokeratin and reciprocal loss of vimentin. These phenotypic changes were associated with increased E-cadherin expression with a shift in [unreadable]-..
  20. The role of Vimentin in cell adhesion and lung cancer metastasis
    LAUREN SMITH HAVEL; Fiscal Year: 2013
    ..The intermediate filament, vimentin, is upregulated in migrating cells, indicating a role in metastasis...
  21. Roles of CC chemokine activity in mast cell responses and ocular allergy
    Santa Jeremy Ono; Fiscal Year: 2012
    ..For the third aim, the roles of potential proteomic mediators of MIP-1[unreadable]-CCR1 activity, specifically vimentin and PI3K[unreadable], will be assessed using the in vitro mast cell assays and in vivo adoptive transfer model...
  22. Effects of NSAIDs on the genesis of streptococcal myonecrosis after trauma
    Amy Evelyn Bryant; Fiscal Year: 2013
    ..human skeletal muscle cells increases the binding of invasive GAS and that surface-expressed skeletal muscle vimentin mediates this adhesion...
  23. Cadherin Regulation in Dermal Endothelial Cells
    Andrew P Kowalczyk; Fiscal Year: 2013
    ..functions as a scaffold for a series of proteins termed catenins, which couple VE-cadherin to actin and vimentin cytoskeletal networks. p120 catenin regulation of VE-cadherin is the focus of this proposal...
  24. Molecular targets of Corneal Anti-fibrosis
    Royce Mohan; Fiscal Year: 2013
    ..A second innovative discovery, afforded by the chemical genetic approach, illuminated vimentin, a type III intermediate filament (IF) protein, as the binding target of WFA...
  25. Defining the role of eIF4F in metastatic castration resistant prostate cancer
    ANDREW CALEB HSIEH; Fiscal Year: 2013
    ..Moreover, he has identified a cohort of eIF4F regulated pro-invasion mRNAs (YB-1, MTA-1, CD44, and vimentin) in prostate cancer necessary for tumor invasion and metastasis, which he showed can be pharmacologically ..
  26. Molecular Regulation of Epithelial-Mesenchymal Transitions
    DOUGLAS CHASE DEAN; Fiscal Year: 2010
    ..transition defects in the corneal endothelium, with acquisition of E cadherin expression and loss of vimentin expression. Such epithelial/ectodermal vs...
  27. AKT-Vimentin interaction;a potential role in soft tissue sarcoma progression and
    MENASHE BARELI; Fiscal Year: 2013
    ..immuno -incompetent mice, AKT inhibition interferes with STS growth, perhaps by disrupting AKT interaction with vimentin, a critical structural protein that may also have oncologically-relevant functional properties...
  28. The role of FGF signaling in suppressing astrogliosis
    Jean M Hebert; Fiscal Year: 2012
    ..preliminary data indicate that in FGF receptor triple mutants there is a tremendous increase in astrocytic GFAP, Vimentin, and Nestin expression, indicative of astrogliosis...
  29. Regulation and Function of Intermediate Filaments in Cell Mechanics
    Robert D Goldman; Fiscal Year: 2013
    ..in the assembly states and mechanical properties of cytoskeletal IF, specifically the type III IF composed of vimentin (VIF), play important roles in regulating the micromechanical properties of cells in response to mechano- and ..
  30. ACTIONS OF CYCLIC GMP IN SMOOTH MUSCLE
    Thomas Lincoln; Fiscal Year: 1999
    ..that may be involved in localizing cGMP kinase to substrates is the cytoskeletal intermediate filament protein vimentin. We propose to study the mechanism by which cGMP binds to cytoskeletal vimentin in vitro and in the intact cell...
  31. Communication between platelet SERT and plasma 5HT
    Fusun Kilic; Fiscal Year: 2013
    ..surface SERT by focusing on the intracellular tethering of SERT by Rab4, and the 5HT-mediated phosphorylation of vimentin that promotes SERT internalization in platelets...
  32. Corneal Epithelial Growth Factors and Receptors
    STEVEN EUGENE WILSON; Fiscal Year: 2013
    ..The Specific aims of this proposal are to test the hypotheses that 1) development of mature vimentin+/[unreadable]-smooth muscle actin+/desmin+ (V+A+D+) myofibroblasts from corneal stromal or bone marrow- derived ..
  33. miRNAs 424 and 152 as Mediators of the Mesenchymal Phenotype in Breast Cancer EMT
    David J Drasin; Fiscal Year: 2013
    ..this idea, our preliminary data indicate miR-424 is sufficient to induce th mesenchymal-like genes N-cadherin and vimentin, which typically correlate positively with breast cancer metastasis in vivo, without affecting epithelial ..
  34. Alemtuzumab and Regulatory T Cells for Heart Transplant Tolerance in Monkeys
    Angus W Thomson; Fiscal Year: 2013
    ..of anti-donor T cell responses, (iv) development of anti-donor antibodies (Abs), (v) development of anti-vimentin and anti-myosin Abs, and T cell responses to these autoantigens, and (vi) assessment of memory T cell responses...
  35. Mechanisms of Angiogenic Switch Activation During Wound Repair
    Kayla J Bayless; Fiscal Year: 2013
    ..We hypothesize that pro-angiogenic factors stimulate phosphorylation and calpain-dependent cleavage of vimentin, which controls downstream activation of membrane-associated proteinases and initiates sprout formation...
  36. The Effect of Arterial Stiffening on Endothelial Monolayers
    Maria E Murray; Fiscal Year: 2012
    ..This will be done by investigating the cytoskeleton of the cells - particularly the vimentin intermediate filament network as it has been shown to play a role in permeability of the monolayer...
  37. The Role of CARMIL2 in Cell Migration and Invasion
    MICHAEL HUNTER LANIER; Fiscal Year: 2013
    ..b>Vimentin expression is a hallmark of the epithelial-mesenchymal transition in carcinoma cells and correlates strongly with ..
  38. Control of lung cancer invasion and metastasis by vimentin
    Adam I Marcus; Fiscal Year: 2013
    ..Numerous reports show that the intermediate filament protein vimentin is overexpressed in invasive human tumors but is nearly undetectable in non- invasive, stationary tumors...
  39. LCM Analysis and Mouse Models to Validate miRs in Prostate Tumor Progression
    ZENDRA ELIZABETH ZEHNER; Fiscal Year: 2012
    ..verified that miR-17-3p functions in vitro and in vivo as a prostate tumor suppressor and targets the protein, vimentin. Aim 1 will define the impact of miR17-3p to orthoptopic tumorigenicty and metastasis, and elucidate additional ..
  40. Rap1Gap and Tumor Progression
    Judy L Meinkoth; Fiscal Year: 2013
    ..Rap1GAP-deficient tumor cells lacked E-cadherin and acquired the expression of vimentin, indicative of epithelial-to-mesenchymal transition...
  41. Gene-Product Auto-Targeting to Tumor Vessels
    Shulin Li; Fiscal Year: 2013
    ..We also revealed that this tumor-targeting IL-12 (IL-12-VNTANST) binds to vimentin, a protein known as an intracellular protein and increased in metastatic tumors...
  42. Endocrine Status of MG Stroma Alters Breast CA Invasion
    Pepper Schedin; Fiscal Year: 2004
    ..The effects of mammary matrix on key markers of EMT, actin fiber organization, and expression of E-cadherin, vimentin, gelsolin and Fspl proteins, will be determined biochemically...
  43. PHARMACOLOGY OF FETAL STRIATAL TISSUE TRANSPLANTS
    Andrew Norman; Fiscal Year: 1992
    ..presence of astrocytes in the transplant and host brain using the markers for glial fibrillary acidic protein and vimentin which label mature and immature astrocytes respectively...
  44. Mechanisms of fibrosis in pediatric liver diseases
    Rebecca G Wells; Fiscal Year: 2011
    ..1) that cholangiocyte dysfunction, namely the acquisition of mesenchymal characteristics including expression of vimentin, is typical of pediatric biliary fibrosis;2) that cholangiocytes are mechanosensitive, and that their responses ..
  45. AUTOANTIBODIES TO CELLULAR MATRIX ANTIGENS IN CFS
    ENG TAN; Fiscal Year: 2000
    ..Cellular structures (nuclear envelope, vimentin-containing intermediate filaments and a nuclear matrix particle visualized in immunofluorescence as reticulated ..
  46. ENDOTHELIAL CELL CYTOSKELETON IN HYPEROXIA
    Susan Harding; Fiscal Year: 1992
    ..studies will involve all three cytoskeletal filament systems, the microfilaments (actin), intermediate filaments (vimentin, desmin and keratin), and microtubules (tubulin). We will pursue the following specific aims...
  47. MECHANISMS OF INFLAMMATORY EDEMA
    DOUGLAS SHASBY; Fiscal Year: 2005
    ..It is also linked via gamma-cantenin to vimentin. Our data and that of others indicate that histamine decreases the association of VE-cadherin with the ..
  48. VIMENTINSS REGULATORY FACTORS INVOLVED IN DEVELOPMENT
    ZENDRA ZEHNER; Fiscal Year: 2003
    ..The cytoskeletal proteins, vimentin and desmin, provide an excellent model system for determining how genes are differentially expressed during ..
  49. INTERMEDIATE FILAMENTS--MOLECULAR APPROACH TO FUNCTION
    STEPHEN TAPSCOTT; Fiscal Year: 1990
    ..will be the contribution of desmin to myofibril integrity; the ability of mature neurons to transport and degrade vimentin; the role of neurofilaments in neurite stability; and the role of IF in cell viability and differentiation...
  50. MECHANISMS AND BIOLOGICAL ROLE OF KINESIN PROCESSIVITY
    Daniel Pierce; Fiscal Year: 2001
    ..It also functions in transport of non-membranous vimentin particles and organization of the intermediate filaments...
  51. Mechanisms of Calmodulin-dependent EC Barrier Regulation
    Alexander Verin; Fiscal Year: 2004
    ..proteins including Ca2+/CaM-dependent regulatory protein caldesmon and CaMKII targets, filamin, tau and vimentin. Together, these data clearly convey the complex involvement of Ca2+/CaM-dependent signaling pathways in the ..
  52. Polarized Targeting of Metabotropic Glutamate Receptors
    Anna Francesconi; Fiscal Year: 2004
    ..Preliminary results have identified three proteins, alpha-actinin-4, myosin IC and vimentin as potential components of the mGluRlb associated complex...
  53. MICROTUBULES IN TESTICULAR TOXICITY OF CARBENDAZIM
    MARION MILLER; Fiscal Year: 1999
    ..The vimentin-knockout mouse provides an excellent experimental model for testing the role of intermediate filaments in the ..
  54. HOW DO NEURONS REPLACE VIMENTIN WITH NEUROFILAMENTS?
    Thomas Shea; Fiscal Year: 1999
    ..of neuronal intermediate filaments (IFs) accompanies these events, in which neurons rely on the generic vimentin IF system to initiate the outgrowth of highly-plastic, putative axonal neurites, then subsequently deposit ..
  55. MOLECULAR ANALYSIS OF CYTOKERATINS DURING TUMOR INVASION
    Mary Hendrix; Fiscal Year: 1992
    ..expression of cytokeratins (CKs) by certain human melanoma cells, in addition to their classical expression of vimentin, plays an important role in contributing to the invasive behavior of the highly metastatic tumor cells...
  56. KIDNEY INJURY MOLECULE-1 IN RENAL INJURY AND REPAIR
    Zhiwei Zhang; Fiscal Year: 2003
    ..portion, and its expression in the postischemic kidney is also co-localized with the de-differentiation marker vimentin and proliferation marker bromodeoxyuridine...
  57. ROLE OF EXTRACELLULAR MATRIX IN MORPHOGENESIS
    Elizabeth Hay; Fiscal Year: 1993
    ..We expect vimentin mRNA to appear before cells elongate, actin mRNA to move to the front end as the cells elongate and type I ..
  58. FUNCTION OF GFAP IN ASTROCYTE DEVELOPMENT AND DISEASE
    Albee Messing; Fiscal Year: 2002
    ..fiber formation by crossing the GFAP transgene into mice that are unable to express the endogenous mouse GFAP, vimentin, or alphaB-crystallin (three of the major components of Rosenthal fibers)...
  59. DIGITAL IMAGING FLUORESCENCE MICROSCOPY FACILITY
    Kevin Strange; Fiscal Year: 1991
    ..in single living cells and to localize ankyrin with respect to other membrane an cytoskeletal components such as vimentin, tubulin, the Na+/K+ ATPase, etc. Finally, Dr...
  60. Mechanisms of TGFbeta-mediated fibroblastic transition
    Andrei Bakin; Fiscal Year: 2006
    ..in cell morphology, reorganization of the cell cytoskeleton, expression of fibroblastic markers (fibronectin, vimentin) and enhancement of cell migration...
  61. GLIAL FILAMENT ASSOCIATED PROTEINS IN HUMAN ASTROCYTOMAS
    Omar Skalli; Fiscal Year: 2000
    ..of astrocytoma cells; 3) To characterize at the molecular level the interactions between IFAP 300, GFAP, vimentin, and the plasma membrane; 4) To determine the factors regulating the interactions between IFAP 300 and glial ..
  62. MOLECULAR REGULATION OF INTERMEDIATE FILAMENT STRUCTURE
    Robert Evans; Fiscal Year: 1991
    ..The proposed experiments will use the intermediate filament protein vimentin as a model for phosphorylation regulated filament organization...