glial fibrillary acidic protein

Summary

Summary: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.

Top Publications

  1. ncbi Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    Eric A Bushong
    National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093 0608, USA
    J Neurosci 22:183-92. 2002
  2. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
  3. doi GFAP in health and disease
    J Middeldorp
    Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Prog Neurobiol 93:421-43. 2011
  4. ncbi hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
    L Zhuo
    Department of Pathobiological Sciences, Waisman Center, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Genesis 31:85-94. 2001
  5. ncbi Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)
    L F Eng
    Department of Pathology, VAPA Health Care System, Palo Alto 94304, USA
    Neurochem Res 25:1439-51. 2000
  6. ncbi Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins
    S Safavi-Abbasi
    Department of Anatomy and Developmental Neurobiology, , , Germany
    Glia 36:102-15. 2001
  7. ncbi Protective role of reactive astrocytes in brain ischemia
    Lizhen Li
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 28:468-81. 2008
  8. ncbi Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    T G Bush
    Medical Research Council Cambridge Centre for Brain Repair, and Department of Anatomy, University of Cambridge, United Kingdom
    Neuron 23:297-308. 1999
  9. ncbi Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
    E D Hall
    Central Nervous System Diseases Research, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan, USA
    Glia 23:249-56. 1998
  10. ncbi Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium
    N L Johnston-Wilson
    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD 21287 4933, USA
    Mol Psychiatry 5:142-9. 2000

Research Grants

  1. Defining a clinically relevant time point for astrocyte targeted therapy in ALS
    Brian K Kaspar; Fiscal Year: 2013
  2. Alexander Disease: Cellular and Molecular Mechanisms
    Albee Messing; Fiscal Year: 2012
  3. Johnny J He; Fiscal Year: 2014
  4. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey A Johnson; Fiscal Year: 2013
  5. Philip K Liu; Fiscal Year: 2014
  6. Perivascular astrocyte morphology during motor neuron degeneration
    Ileana Lorenzini; Fiscal Year: 2012
  7. Tonia S Rex; Fiscal Year: 2016
  8. Diana M Sama; Fiscal Year: 2015
  9. J Timothy Greenamyre; Fiscal Year: 2015
  10. GFAP Biomarker of Whole Body Cooling Outcome and Efficacy in the Neonate with HIE
    Allen D Everett; Fiscal Year: 2012

Detail Information

Publications431 found, 100 shown here

  1. ncbi Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    Eric A Bushong
    National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093 0608, USA
    J Neurosci 22:183-92. 2002
    ..of astrocyte form and distribution is based predominantly on studies that used the astrocytic marker glial fibrillary acidic protein (GFAP) and on studies using metal-impregnation techniques...
  2. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
    ....
  3. doi GFAP in health and disease
    J Middeldorp
    Department of Astrocyte Biology and Neurodegeneration, Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Prog Neurobiol 93:421-43. 2011
    b>Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development...
  4. ncbi hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo
    L Zhuo
    Department of Pathobiological Sciences, Waisman Center, University of Wisconsin, 1500 Highland Avenue, Madison, WI 53705 2280, USA
    Genesis 31:85-94. 2001
    ..mouse, we have generated a transgenic line expressing Cre recombinase under the control of the human glial fibrillary acidic protein (hGFAP) promoter...
  5. ncbi Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)
    L F Eng
    Department of Pathology, VAPA Health Care System, Palo Alto 94304, USA
    Neurochem Res 25:1439-51. 2000
    It is now well established that the glial fibrillary acidic protein (GFAP) is the principal 8-9 nm intermediate filament in mature astrocytes of the central nervous system (CNS)...
  6. ncbi Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins
    S Safavi-Abbasi
    Department of Anatomy and Developmental Neurobiology, , , Germany
    Glia 36:102-15. 2001
    ..These experiments demonstrate that the recently described RhoA-mediated signaling cascade between the cell surface and cytoskeletal proteins is only one of several signaling pathways acting on the astrocytic cytoskeleton...
  7. ncbi Protective role of reactive astrocytes in brain ischemia
    Lizhen Li
    Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology at Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Cereb Blood Flow Metab 28:468-81. 2008
    ..Previously, we generated mice deficient in two intermediate filament (IF) proteins, glial fibrillary acidic protein (GFAP) and vimentin, whose upregulation is the hallmark of reactive astrocytes...
  8. ncbi Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice
    T G Bush
    Medical Research Council Cambridge Centre for Brain Repair, and Department of Anatomy, University of Cambridge, United Kingdom
    Neuron 23:297-308. 1999
    ....
  9. ncbi Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
    E D Hall
    Central Nervous System Diseases Research, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan, USA
    Glia 23:249-56. 1998
    ..the time course of microglial (major histocompatibility-II antigen immunoreactivity) and astrocytic (glial fibrillary acidic protein immunoreactivity) activation in relation to the course of motor neuron disease in the TgN(SOD1-G93A)..
  10. ncbi Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium
    N L Johnston-Wilson
    Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, MD 21287 4933, USA
    Mol Psychiatry 5:142-9. 2000
    ..Four of these are forms of glial fibrillary acidic protein (GFAP), one is dihydropyrimidinase-related protein 2, and the sixth is ubiquinone cytochrome c ..
  11. ncbi In vitro characterization of a spontaneously immortalized human Müller cell line (MIO-M1)
    G Astrid Limb
    Division of Cell Biology, Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK
    Invest Ophthalmol Vis Sci 43:864-9. 2002
    ..To characterize a spontaneously immortalized human Müller cell line and to determine whether it retains the characteristics of primary isolated cells without undergoing differentiation in vitro...
  12. ncbi Astrocyte intermediate filaments in CNS pathologies and regeneration
    Milos Pekny
    Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, Box 430, 405 30 Goteborg, Sweden
    J Pathol 204:428-37. 2004
    ..GFAP is the principal astrocyte intermediate filament protein and dominant mutations in the GFAP gene have been shown to lead to Alexander disease, a fatal neurodegenerative condition in humans...
  13. pmc Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    Proc Natl Acad Sci U S A 90:10061-5. 1993
    ..mice were generated in which the cytokine interleukin 6 (IL-6), under the regulatory control of the glial fibrillary acidic protein gene promoter, was overexpressed in the CNS...
  14. ncbi Dopamine depletion impairs precursor cell proliferation in Parkinson disease
    Günter U Höglinger
    INSERM U289 Hôpital de la Salpetrière, F 75651 Paris, France
    Nat Neurosci 7:726-35. 2004
    ..These observations suggest that the generation of neural precursor cells is impaired in Parkinson disease as a consequence of dopaminergic denervation...
  15. pmc Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury
    Roberta Brambilla
    The Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Exp Med 202:145-56. 2005
    ..dn) form of the inhibitor of kappaB alpha under the control of an astrocyte-specific promoter (glial fibrillary acidic protein [GFAP]-dn mice) leads to a dramatic improvement in functional recovery 8 wk after contusive spinal ..
  16. ncbi Glial reactivity, an early feature of diabetic retinopathy
    E Rungger-Brandle
    Cell Biology Laboratory, University Eye Clinic, Geneva, Switzerland
    Invest Ophthalmol Vis Sci 41:1971-80. 2000
    ..To characterize early structural gliotic reactions in retinal Müller cells, astrocytes, and microglia in experimentally induced diabetes...
  17. ncbi A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat
    Veronica Asnaghi
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes 52:506-11. 2003
    We tested the hypothesis that the apoptosis of inner retina neurons and increased expression of glial fibrillary acidic protein (GFAP) observed in the rat after a short duration of diabetes are mediated by polyol pathway activity...
  18. ncbi The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells
    Cindi M Morshead
    Department of Surgery, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 18:76-84. 2003
    ..Using a transgenic mouse expressing herpes-simplex virus thymidine kinase from the glial fibrillary acidic protein (GFAP) promotor, we have selectively killed dividing GFAP-positive cells in the presence of ..
  19. doi Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain
    Sara Ekmark-Lewén
    Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, Uppsala, Sweden
    Restor Neurol Neurosci 28:311-21. 2010
    ..The aims for this study were to compare the temporal and spatial expression pattern of vimentin- and glial fibrillary acidic protein (GFAP) in a weight drop model of mild cerebral contusion injury in the rat...
  20. pmc Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention
    Linda Papa
    Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, FL, USA
    Ann Emerg Med 59:471-83. 2012
    This study examines whether serum levels of glial fibrillary acidic protein breakdown products (GFAP-BDP) are elevated in patients with mild and moderate traumatic brain injury compared with controls and whether they are associated with ..
  21. ncbi Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma
    Linda E Pelinka
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Research Unit of the Austrian Worker s Compensation Board, Vienna, Austria
    J Trauma 57:1006-12. 2004
    This study aimed to determine whether glial fibrillary acidic protein (GFAP) is released after traumatic brain injury (TBI), whether GFAP is related to brain injury severity and outcome after TBI, and whether GFAP is released after ..
  22. doi Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase
    Masahiro Honda
    Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Yamaguchi, Japan
    J Trauma 69:104-9. 2010
    Serum glial fibrillary acidic protein (GFAP) is a specific predictor of brain damage and neurologic outcome in patients with traumatic brain injury (TBI)...
  23. ncbi Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration
    Ulrika Wilhelmsson
    Department of Medical Biochemistry, Sahlgrenska Academy at Goteborg University, SE 405 30 Goteborg, Sweden
    J Neurosci 24:5016-21. 2004
    ..lesion model in mice, we found that reactive astrocytes devoid of the intermediate filament proteins glial fibrillary acidic protein and vimentin (GFAP-/-Vim-/-), and consequently lacking intermediate filaments (Colucci-Guyon et al...
  24. ncbi Non-invasive imaging of GFAP expression after neuronal damage in mice
    Lingyun Zhu
    Xenogen Corporation, 860 Atlantic Avenue, Alameda, CA 94501, USA
    Neurosci Lett 367:210-2. 2004
    Up-regulation of glial fibrillary acidic protein (GFAP) expression is often used as a surrogate marker of neuronal damage...
  25. pmc The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes
    Jun ichi Satoh
    Department of Immunology, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 165:577-92. 2004
    ..and double-immunolabeling analysis showed that the 14-3-3 protein interacts with both vimentin and glial fibrillary acidic protein in cultured human astrocytes...
  26. doi Glial fibrillary acidic protein-expressing neural progenitors give rise to immature neurons via early intermediate progenitors expressing both glial fibrillary acidic protein and neuronal markers in the adult hippocampus
    Y Liu
    Department of Anatomy, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Neuroscience 166:241-51. 2010
    ..in the subgranular zone (SGZ) of the dentate gyrus, where primary neuronal progenitors that express glial fibrillary acidic protein (GFAP) develop into granule neurons...
  27. ncbi DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain
    T Takizawa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
    Dev Cell 1:749-58. 2001
    ..We show that astrocytes, as judged by glial fibrillary acidic protein (GFAP) expression, never emerge from neuroepithelial cells on embryonic day (E) 11...
  28. doi GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study
    P E Vos
    Departments of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurology 75:1786-93. 2010
    ..This study aims to validate glial fibrillary acidic protein (GFAP) and S100B concentrations in blood as outcome predictors of TBI using cutoff levels of 1...
  29. pmc Proinflammatory cytokines increase glial fibrillary acidic protein expression in enteric glia
    G B T von Boyen
    Department of Medicine I Gastroenterology, University of Ulm, Albert Einstein Allee 11, 89069 Ulm, Germany
    Gut 53:222-8. 2004
    Enteric glia protect the integrity of the gut, as loss of enteric glial fibrillary acidic protein (GFAP) positive (+) glia leads to a haemorrhagic jejunoileitis...
  30. pmc Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide
    Saurav Brahmachari
    Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Neurosci 26:4930-9. 2006
    Increased expression of glial fibrillary acidic protein (GFAP) represents astroglial activation and gliosis during neurodegeneration. However, the molecular mechanism behind increased expression of GFAP in astrocytes is poorly understood...
  31. ncbi Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression
    Geoffrey P Lewis
    Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, California 93106, USA
    Int Rev Cytol 230:263-90. 2003
    ..The up-regulation of one of these intermediate filament proteins, glial fibrillary acidic protein (GFAP), historically has been an indicator of "stress" in central nervous system (CNS) ..
  32. doi Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-delta
    Simone A van den Berge
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Aging Cell 9:313-26. 2010
    ..the SVZ specifically expresses an assembly-compromised isoform of the intermediate filament protein glial fibrillary acidic protein (GFAP-delta)...
  33. pmc Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study
    Stefania Mondello
    Department of Anesthesiology, University of Florida, 1600 S, W, Archer Road, Gainesville, FL 32610 0254, USA
    Crit Care 15:R156. 2011
    ..to investigate the relationships among neuronal (Ubiquitin carboxy-terminal hydrolase L1 [UCH-L1]) and glial (glial fibrillary acidic protein [GFAP]) biomarker levels in serum, neuroradiological findings and outcomes after severe TBI.
  34. ncbi Two distinct subpopulations of nestin-positive cells in adult mouse dentate gyrus
    Satoshi Fukuda
    Department of Integrated Biosciences, University of Tokyo, Kashiwa 277 8562, Japan
    J Neurosci 23:9357-66. 2003
    ..1 M(Omega) (geometric mean), and their radial processes were stained with anti-glial fibrillary acidic protein antibody...
  35. ncbi Adult human subventricular, subgranular, and subpial zones contain astrocytes with a specialized intermediate filament cytoskeleton
    Reinko F Roelofs
    Netherlands Institute for Brain Research, Graduate School Neurosciences, Amsterdam, The Netherlands
    Glia 52:289-300. 2005
    Human glial fibrillary acidic protein-delta (GFAP-delta) is a GFAP protein isoform that is encoded by an alternative splice variant of the GFAP-gene...
  36. ncbi Three-dimensional confocal morphometry reveals structural changes in astrocyte morphology in situ
    Alexandr Chvatal
    Department of Neurobiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Neurosci Res 85:260-71. 2007
    ..Our data show that astrocytes in brain slices undergoing hypotonic stress display cell volume regulation as well as transient changes in morphology...
  37. ncbi Blood-retinal barrier disruption and ultrastructural changes in the hypoxic retina in adult rats: the beneficial effect of melatonin administration
    C Kaur
    Department of Anatomy, Yong Loo Lin School of Medicine, Blk MD10, 4 Medical Drive, National University of Singapore, Singapore 117597
    J Pathol 212:429-39. 2007
    ..In hypoxic rats, mRNA and protein expression of glial fibrillary acidic protein (GFAP) and aquaporin-4 (AQ4) were significantly increased...
  38. doi Live imaging of neuroinflammation reveals sex and estrogen effects on astrocyte response to ischemic injury
    Pierre Cordeau
    Department of Anatomy and Physiology, Universite Laval, Quebec, Canada
    Stroke 39:935-42. 2008
    ..We sought to develop a model system for live analysis of brain inflammatory response in ischemic injury...
  39. doi Endocannabinoids mediate neuron-astrocyte communication
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid 28002, Spain
    Neuron 57:883-93. 2008
    ..They also reveal the existence of an endocannabinoid-glutamate signaling pathway where astrocytes serve as a bridge for nonsynaptic interneuronal communication...
  40. ncbi Expression of glial fibrillary acidic protein and glutamine synthetase by Müller cells after optic nerve damage and intravitreal application of brain-derived neurotrophic factor
    Hao Chen
    Department of Pharmacology, University of Tennessee at Memphis, USA
    Glia 38:115-25. 2002
    ..Using immunocytochemistry and Western blot analysis, temporal changes in the expression of glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS) were examined in rats after optic nerve crush alone, or in ..
  41. ncbi Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity
    James P O'Callaghan
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Expert Opin Drug Saf 4:433-42. 2005
    ..Using a panel of known neurotoxic agents, the authors have shown that the astroglial protein, glial fibrillary acidic protein (GFAP), can serve as one such biomarker of neurotoxicity...
  42. ncbi Expression of interleukin-17 in ischemic brain tissue
    G Z Li
    Department of Neurology, the First Affiliated Clinic College of Harbin Medical University, Harbin, China
    Scand J Immunol 62:481-6. 2005
    ..IL-17 production by neuroglial cells was assayed by double-staining using antibody glial fibrillary acidic protein (GFAP) and antibody IL-17...
  43. ncbi Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    J Neurosci 26:2467-73. 2006
    ..Both compounds also reduced interleukin (IL)-12p40, IL-1alpha, and IL-1beta and increased IL-RA and TGF-beta1 mRNA. Therefore, both thalidomide and lenalidomide bear promise as therapeutic interventions for the treatment of ALS...
  44. ncbi Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis
    Graham W Kay
    Agriculture and Life Sciences Division, Lincoln University, Canterbury, New Zealand
    Brain Pathol 16:110-6. 2006
    ..This prenatal activation of non-neuronal cells within the affected brain indicates the onset of pathogenesis during brain development and that an ordered sequence of glial activation precedes neurodegeneration...
  45. pmc Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus
    Karin Borges
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 201:416-27. 2006
    ..These findings demonstrate astrocyte degeneration in the mouse dentate hilus specifically in the mouse pilocarpine epilepsy model, followed by astrogenesis leading to hilar repopulation...
  46. ncbi Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  47. ncbi Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration
    Esther Carrasco
    Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Diabetes Care 30:2902-8. 2007
    ..To test the hypothesis that a reduction of somatostatin (SST) in the retina exists in patients without clinically detectable diabetic retinopathy and that it is associated with retinal neurodegeneration...
  48. doi GFAP promoter elements required for region-specific and astrocyte-specific expression
    Youngjin Lee
    Department of Neurobiology and Civitan International Research Center, Evelyn F McKnight Brain Institute and Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0021, USA
    Glia 56:481-93. 2008
    b>Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein in astrocytes, one of the most abundant cell types in the vertebrate central nervous system (CNS)...
  49. pmc Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways
    Guomei Tang
    Department of Pathology, Center for Neurobiology and Behavior, Center for Parkinson s Disease and Other Movement Disorders, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 17:1540-55. 2008
    b>Glial fibrillary acidic protein (GFAP) is the principle intermediate filament (IF) protein in astrocytes...
  50. doi Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability
    Hussein Mansour
    School of Medical Sciences Anatomy and Histology and Bosch Institute, University of Sydney, Sydney, NSW 2006, Australia
    Aging Cell 7:526-40. 2008
    ..b>Glial fibrillary acidic protein (GFAP), S100 and Pax2 were used to identify astrocytes, and blood vessels were localized using ..
  51. pmc Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation
    Esther Carrasco
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Instituto de Salut Carlos III ISCIII, Barcelona, Spain
    Mol Vis 14:1496-502. 2008
    ..Retinal neurodegeneration was assessed by measuring glial fibrilar acidic protein (GFAP) by confocal laser microscopy and counting the apoptotic TUNEL positive cells in which nuclear fragmentation as well as condensation were present...
  52. doi Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina
    Aysegül Tura
    University Eye Hospital of the Center of Ophthalmology at the Eberhard Karls University of Tübingen, Tubingen, Germany
    Invest Ophthalmol Vis Sci 50:452-61. 2009
    ..To analyze the outcomes of Rho-kinase (ROCK) inhibition on retinal cell survival and glial reactivity under adverse conditions...
  53. doi Glial fibrillary acidic protein and S-100 colocalization in the enteroglial cells in dilated and nondilated portions of colon from chagasic patients
    Alexandre B M da Silveira
    Anatomy Sector, Morphology Department, Biomedical Sciences Institute, Universidade Federal de Uberlandia, 38400 902, Brazil
    Hum Pathol 40:244-51. 2009
    ..were to characterize the phenotype of enteric glial cells according to the expression of S-100 and glial fibrillary acidic protein and to look for correlation between these data and the neuronal loss in the colon of chagasic ..
  54. doi The impact of age and gender on the striatal astrocytes activation in murine model of Parkinson's disease
    Agnieszka Ciesielska
    Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
    Inflamm Res 58:747-53. 2009
    ..The aim of the present study was to determine how aging and gender influence the response of astrocytes to 1-methyl-4-phenyl-1,2,3,6-tetrahydropiridine (MPTP) intoxication...
  55. doi Retinal vascular changes after glial disruption in rats
    Weiyong Shen
    Save Sight Institute, University of Sydney, Sydney, Australia
    J Neurosci Res 88:1485-99. 2010
    ..in regions of glial disruption, as reflected by reduced expression of GS and increased expression of glial fibrillary acidic protein and vimentin...
  56. pmc Structural remodeling of fibrous astrocytes after axonal injury
    Daniel Sun
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 30:14008-19. 2010
    ..They are characterized by hypertrophy of the soma and processes and an increase in the expression of glial fibrillary acidic protein. Because the cells obscure each other in immunostaining, little is known about the behavior of a ..
  57. doi Micro-structured materials and mechanical cues in 3D collagen gels
    James B Phillips
    Department of Life Sciences, The Open University, Milton Keynes, UK
    Methods Mol Biol 695:183-96. 2011
    ..These systems therefore provide a highly controllable mechanical and chemical micro-environment for investigating a wide range of cellular responses...
  58. pmc Interplay between SIN3A and STAT3 mediates chromatin conformational changes and GFAP expression during cellular differentiation
    Pei Yi Cheng
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    PLoS ONE 6:e22018. 2011
    ..The mechanisms of neural development underlying suppression and de-suppression of differentiation-related genes for cell fate specifications are not well understood...
  59. pmc Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats
    Ayano Katagiri
    Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan
    Mol Pain 8:23. 2012
    ..We therefore studied the reflex to noxious mechanical or heat stimulation of the tongue, P2Y12R and glial fibrillary acidic protein (GFAP) immunohistochemistries in the trigeminal ganglion (TG) in a rat model of unilateral lingual ..
  60. doi A literature review of the feasibility of glial fibrillary acidic protein as a biomarker for stroke and traumatic brain injury
    Leora Schiff
    United BioSource Corporation, Lexington, MA 0242, USA
    Mol Diagn Ther 16:79-92. 2012
    ..b>Glial fibrillary acidic protein (GFAP), a brain-specific biomarker that is released into the blood following TBI and stroke, is being ..
  61. pmc P53 is required for the developmental restriction in Müller glial proliferation in mouse retina
    Yumi Ueki
    Department of Biological Structure, University of Washington, Seattle, Washington, USA
    Glia 60:1579-89. 2012
    ..These data show that p53 plays an essential role in limiting the potential of Müller glia to re-enter the mitotic cycle as the retina matures during postnatal development...
  62. doi Neuromyelitis optica lesions may inform multiple sclerosis heterogeneity debate
    Wolfgang Bruck
    Department of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Ann Neurol 72:385-94. 2012
    ..The aim of our study was to compare the histological characteristics of early active demyelinating NMO and MS brain lesions...
  63. doi Temporal relationship between aquaporin-4 and glial fibrillary acidic protein in cerebellum of neonate and adult rats administered a BBB disrupting spider venom
    Leila Miguel Stavale
    Department of Histology and Embryology, Institute of Biology, State University of Campinas UNICAMP, 13 083 970 Campinas, SP, Brazil
    Toxicon 66:37-46. 2013
    Two astrocyte markers, the glial water channel aquaporin-4 (AQP4) and the glial fibrillary acidic protein (GFAP), have been implicated in several physiological and pathological conditions in the central nervous system (CNS) as well as in ..
  64. pmc Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease
    Rujin Tian
    Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032, USA
    Am J Pathol 168:888-97. 2006
    ..neurological disorder caused by mutations in the astrocyte-specific intermediate filament protein glial fibrillary acidic protein (GFAP)...
  65. ncbi Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals
    Ana M Fernandez
    Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Neurosci 27:8745-56. 2007
    ..These results suggest that calcineurin forms part of a molecular pathway whereby reactive astrocytes determine the outcome of the neuroinflammatory process by directing it toward either its resolution or its progression...
  66. doi Intracerebroventricular administration of Shiga toxin type 2 altered the expression levels of neuronal nitric oxide synthase and glial fibrillary acidic protein in rat brains
    Javier Boccoli
    Laboratorio de Fisiopatogenia, Departamento de Fisiologia, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155 Piso 7, Ciudad Autonoma de Buenos Aires, 1121, Argentina
    Brain Res 1230:320-33. 2008
    ..work, we observed that the intracerebroventricular administration of Stx2 increased the expression of glial fibrillary acidic protein (GFAP) leading to astrogliosis...
  67. pmc Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models
    W Xie
    Pain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0531, USA
    Neuroscience 160:847-57. 2009
    ..SNL caused extensive satellite glial cell activation (as defined by glial fibrillary acidic protein [GFAP] immunoreactivity) which peaked on day 1 and was still observed on day 10...
  68. pmc Altered functional properties of satellite glial cells in compressed spinal ganglia
    Haijun Zhang
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Glia 57:1588-99. 2009
    ..SGCs responded within 12 h of the onset of CCD as indicated by an increased expression of glial fibrillary acidic protein (GFAP) in the compressed DRG but to lesser extent in neighboring or contralateral DRGs...
  69. pmc Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model
    Zhi You Cai
    Department of Neurology, Anhui Medical University, Lu an 237005, China
    Neurosci Bull 26:28-36. 2010
    ..To study the neuroprotective mechanism of minocycline against vascular cognitive impairment after cerebral ischemia...
  70. doi Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder
    Lori L Altshuler
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Bipolar Disord 12:541-9. 2010
    ..Specifically, it is not known whether differences in the density and/or volume of neurons or glial cells contribute to tissue volume changes seen on magnetic resonance images...
  71. pmc Distribution of enteric glia and GDNF during gut inflammation
    Georg B T von Boyen
    Department of Medicine I, University of Ulm, Germany
    BMC Gastroenterol 11:3. 2011
    ..The aim of the study was to determine the distribution of EGCs and GDNF during gut inflammation and to elucidate a possible diminished enteric glia network in IBD...
  72. doi RBP-J promotes the maturation of neuronal progenitors
    Okiru Komine
    Laboratory of Molecular Neuroscience, School of Biomedical Science and Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Dev Biol 354:44-54. 2011
    ..This study shows a novel RBP-J function that promotes INP differentiation...
  73. doi BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, D 52074 Aachen, Germany
    Brain Behav Immun 25:1554-68. 2011
    ..In conclusion, we provide evidence that expression of BLBP in activated astrocytes negatively correlates with disease duration and in parallel with remyelination failure...
  74. doi SNARE protein expression in synaptic terminals and astrocytes in the adult hippocampus: a comparative analysis
    Vanessa Schubert
    Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    Glia 59:1472-88. 2011
    ....
  75. doi The metabolism and toxicity of hemin in astrocytes
    Theresa N Dang
    Blood Brain Interactions Group, School of Psychology and Psychiatry, Monash University, Clayton, Vic, Australia
    Glia 59:1540-50. 2011
    ..However, when H(2)O(2) is present at physiological levels, the toxicity of hemin appears to be caused by other mechanisms that may involve bilirubin and carbon monoxide in this model system...
  76. pmc Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling
    Christopher S Ennen
    Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Obstet Gynecol 205:251.e1-7. 2011
    b>Glial fibrillary acidic protein (GFAP) is specific to astrocytes in the central nervous system. We hypothesized that serum GFAP would be increased in neonates with hypoxic-ischemic encephalopathy (HIE) treated with whole-body cooling.
  77. pmc GFAP mutations, age at onset, and clinical subtypes in Alexander disease
    M Prust
    Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Neurology 77:1287-94. 2011
    ..AxD is an astrogliopathy usually characterized on MRI by leukodystrophy and caused by glial fibrillary acidic protein (GFAP) mutations.
  78. ncbi Microglial activation state and lysophospholipid acid receptor expression
    Chui Se Tham
    Molecular Neuroscience Laboratory, Merck Research Laboratories, 3535 General Atomics Court, San Diego, CA 92121, USA
    Int J Dev Neurosci 21:431-43. 2003
    ..The levels of mRNA of LPA1 and S1P receptors was reduced by overnight exposure to S1P, while the same treatment significantly up-regulated the level of LPA3 mRNA...
  79. ncbi Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
    P E Vos
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurology 62:1303-10. 2004
    To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury.
  80. ncbi Gene expression analysis in mice with elevated glial fibrillary acidic protein and Rosenthal fibers reveals a stress response followed by glial activation and neuronal dysfunction
    Tracy L Hagemann
    Wisman Center, University of Wisconsin, Madison, WI 53705, USA
    Hum Mol Genet 14:2443-58. 2005
    ..Together, these data implicate an initial stress response by astrocytes, which results in the activation of microglia and compromised neuronal function...
  81. ncbi Cytoskeletal anchoring of GLAST determines susceptibility to brain damage: an identified role for GFAP
    Susan M Sullivan
    School of Biomedical Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Biol Chem 282:29414-23. 2007
    b>Glial fibrillary acidic protein (GFAP) is an enigmatic protein; it currently has no unambiguously defined role. It is expressed in the cytoskeleton of astrocytes in the mammalian brain...
  82. ncbi Dietary restriction enhances kainate-induced increase in NCAM while blocking the glial activation in adult rat brain
    Sandeep Sharma
    Department of Biotechnology, Guru Nanak Dev University, Amritsar 143005, India
    Neurochem Res 33:1178-88. 2008
    ..neural cell adhesion molecule (NCAM) and its polysialylated form PSA-NCAM and astrocytic marker glial fibrillary acidic protein (GFAP) was assessed following brain injury by intraperitoneal injection of kainic acid or ..
  83. doi In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells
    Ruth Beckervordersandforth
    Institute for Stem Cell Research, Helmholtz Centre Munich German Research Centre for Environmental Health, Neuherberg Munich, Germany
    Cell Stem Cell 7:744-58. 2010
    ..Our work reveals candidate molecular regulators for unique features of aNSCs and facilitates future selective analysis of aNSCs in other functional contexts, such as aging and injury...
  84. ncbi Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons
    Larry C Schmued
    Division of Neurotoxicology, National Center for Toxicological Research FDA, Jefferson, AR 72079, USA
    Brain Res 1035:24-31. 2005
    ..Triple labeling was accomplished by staining degenerating neurons with Fluoro-Jade C, cell nuclei with DAPI and activated astrocytes with GFAP immunofluoresence...
  85. ncbi Live astrocytes visualized by green fluorescent protein in transgenic mice
    L Zhuo
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
    Dev Biol 187:36-42. 1997
    ..protein (hGFP-S65T) was expressed in transgenic mice under the control of the astrocyte-specific glial fibrillary acidic protein (GFAP) promoter...
  86. ncbi Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model
    Stefania Corti
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Milan, Italy
    Brain 130:1289-305. 2007
    ..Our results support the therapeutic potential of neural stem cell fractions through both neurogenesis and growth factors release in motor neuron disorders...
  87. pmc Regional heterogeneity in astrocyte responses following contusive spinal cord injury in mice
    Robin E White
    Neuroscience Graduate Studies Program, Ohio State University, Columbus, Ohio 43210, USA
    J Comp Neurol 518:1370-90. 2010
    ..BrdU) was administered to mice 3 days after SCI, and cells expressing BrdU and the astrocyte marker, glial fibrillary acidic protein (GFAP), were counted at 3, 7, and 49 days post-injury (DPI)...
  88. doi Astrocytic damage is far more severe than demyelination in NMO: a clinical CSF biomarker study
    R Takano
    Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan
    Neurology 75:208-16. 2010
    Loss of aquaporin 4 and glial fibrillary acidic protein (GFAP) with necrosis and demyelination is a prominent pathologic feature of neuromyelitis optica (NMO)...
  89. ncbi Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression
    V Menet
    Institut National de la Santé et de la Recherche Médicale U336, Universite Montpellier II, F 34095 Montpellier, France
    J Neurosci 21:6147-58. 2001
    ..In mature differentiated astrocytes, vimentin is replaced by the IF protein glial fibrillary acidic protein (GFAP)...
  90. ncbi Cell proliferation without neurogenesis in adult primate neocortex
    D R Kornack
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 294:2127-30. 2001
    ..Thus, our results do not substantiate the claim of neurogenesis in normal adult primate neocortex...
  91. ncbi Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord
    C Lagord
    Department of Medicine, Wolfson Research Laboratories, Queen Elizabeth Medical Centre, University of Birmingham, Edgbaston, United Kingdom
    Mol Cell Neurosci 20:69-92. 2002
    ..The cellular localization and temporal pattern of expression of TGFbeta after spinal cord injury suggest that TGFbeta1 modulates the inflammatory and neuronal responses, while TGFbeta2 regulates glial/collagen scarring...
  92. ncbi Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment
    William A Gomes
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Biol 255:164-77. 2003
    ..Therefore, BMPs are likely important mediators of astrocyte development in vivo...
  93. ncbi Astrocytes from mouse brain slices express ClC-2-mediated Cl- currents regulated during development and after injury
    Judit K Makara
    Department of Physiology and Laboratory of Cellular and Molecular Physiology, Semmelweis University Medical School, Budapest, Hungary
    Mol Cell Neurosci 23:521-30. 2003
    ..Current density was significantly lower in a corresponding population of astrocytes isolated from immature brain and in reactive astrocytes within a lesion site...
  94. doi Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus
    A M Espinosa-Oliva
    Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, c Prof Garcia Gonzalez, 2, 41012 Sevilla, Spain
    Neurobiol Aging 32:85-102. 2011
    ..Treatment with RU486, a potent inhibitor of glucocorticoid receptor activation, significantly protected animals against the deleterious effects observed in LPS-stressed animals...
  95. doi TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices
    Min Zhou
    Ordway Research Institute, Albany, New York 12208, USA
    J Neurosci 29:8551-64. 2009
    ..These results support TWIK-1 and TREK-1 as being the major components of the long-sought K(+) channels underlying the passive conductance of mature hippocampal astrocytes...
  96. ncbi Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus
    Weiya Ma
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 Boulevard LaSalle, Verdun, Montreal, Quebec, Canada H4H 1R3
    Pain 99:175-84. 2002
    ..In summary, our data indicate that PSNL activates ERK/MAP and JNK/MAP kinase pathways in astrocytes in the dorsal horn and the gracile nucleus, these events possibly being involved in the pathogenesis of neuropathic pain...
  97. doi Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression
    Qiong Liu
    Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine, Institutes of Brain Science, Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Eur Neuropsychopharmacol 19:796-805. 2009
    ....
  98. ncbi Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    L Holcomb
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nat Med 4:97-100. 1998
    ..This suggests that some aspects of the behavioral phenotype in these mice may be related to an event that precedes plaque formation...
  99. pmc Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor
    S A Koblar
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, 3050 Australia
    Proc Natl Acad Sci U S A 95:3178-81. 1998
    ..the low-affinity leukemia inhibitory factor receptor (LIFR-/-) fail to generate astrocytes expressing glial fibrillary acidic protein (GFAP) when cultured in vitro...
  100. ncbi Release of glial tissue-specific proteins after acute stroke: A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein
    M Herrmann
    Division of Neuropsychology and Behavioral Neurology, Otto von Guericke University, Magdeburg, Germany
    Stroke 31:2670-7. 2000
    This study was aimed at the comparative analysis of serum concentrations of glial fibrillary acidic protein (GFAP) and protein S-100B in patients with acute stroke.
  101. ncbi A comparison of intermediate filament markers for presumptive astroglia in the developing rat neocortex: immunostaining against nestin reveals more detail, than GFAP or vimentin
    M Kalman
    Department of Anatomy, Histology and Embryology, Semmelweis University of Medicine, Tuzoltó 58, 1094, Budapest, Hungary
    Int J Dev Neurosci 19:101-8. 2001
    ..day of birth (P0) and the 18th postnatal day (P18), after immunostaining against nestin, vimentin and glial fibrillary acidic protein (GFAP)...

Research Grants65

  1. Defining a clinically relevant time point for astrocyte targeted therapy in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..astrocytes by breeding transgenic mice contacting the floxed mtSOD1 with mice expressing Cre from the glial fibrillary acidic protein (GFAP) promoter had significant effects in the disease These crosses showed that disease progression ..
  2. Alexander Disease: Cellular and Molecular Mechanisms
    Albee Messing; Fiscal Year: 2012
    ..Brenner Title: Biochemistry and Genetics of Alexander Disease Description (provided by applicant): Glial fibrillary acidic protein (GFAP) is a structural protein found almost exclusively in astrocytes...
  3. Johnny J He; Fiscal Year: 2014
    ..Moreover, we have shown that Tat activates glial fibrillary acidic protein (GFAP) expression in astrocytes and results in astrocyte dysfunction and subsequent neuron death...
  4. The Nrf2-ARE Pathway in Amyotrophic Lateral Sclerosis
    Jeffrey A Johnson; Fiscal Year: 2013
    ..We have generated glial fibrillary acidic protein (GFAP)-Nrf2 mice that selectively overexpress Nrf2 in astrocytes...
  5. Philip K Liu; Fiscal Year: 2014
    ..goal is to evaluate the efficiency of SPION-sORN (and SPION-sODN) for targeting astroglia-specific glial fibrillary acidic protein (GFAP) mRNA...
  6. Perivascular astrocyte morphology during motor neuron degeneration
    Ileana Lorenzini; Fiscal Year: 2012
    ..Although recent publications have documented changes in astrocytes beyond its glial fibrillary acidic protein (GFAP) upregulation, little effort has been dedicated to astrocytes surrounding blood vessels in ..
  7. Tonia S Rex; Fiscal Year: 2016
    ..EpoR76E, decreases levels of C1Q and glial fibrillary acidic protein in the retina of 10 month old DBA/2J mice...
  8. Diana M Sama; Fiscal Year: 2015
    ..Because quiescent NPCs and astrocytes express glial fibrillary acidic protein (GFAP), this study utilizes a novel transgenic mouse in which [unreadable]-catenin signaling is ..
  9. J Timothy Greenamyre; Fiscal Year: 2015
    ..recently developed in our lab, that over- express DJ-1 selectively in astrocytes under control of the glial fibrillary acidic protein promoter...
  10. GFAP Biomarker of Whole Body Cooling Outcome and Efficacy in the Neonate with HIE
    Allen D Everett; Fiscal Year: 2012
    ..project of subacute brain injury biomarkers, we have identified that the astrocyte-specific protein glial fibrillary acidic protein (GFAP) is a circulating biomarker of brain injury in neonates with HIE and neonates on ECMO support ..
  11. In vivo Profiling of Glial and Neuronal Activities in Psychostimulant Abuse
    Philip K Liu; Fiscal Year: 2010
    ..The targets to be investigated in this project are mRNAs of glial fibrillary acidic protein (GFAP) and neuronal cFos protein...
  12. Non-Invasive Quantitation of Cellular and Biochemical Changes in Hereditary Ataxi
    GULIN OZ; Fiscal Year: 2009
    ..Associations will be sought between these MRS markers and glial fibrillary acidic protein levels in cerebrospinal fluid (CSF) as determined by ELISA as an independent measure of reactive ..
  13. Ultra-sensitive magnetic assays for rapid detection of stroke biomarkers
    MARK S DIIORIO; Fiscal Year: 2012
    ..A number of studies have shown glial fibrillary acidic protein (GFAP) to be a promising biomarker...
  14. Orly Lazarov; Fiscal Year: 2016
    ..of siRNA for PS1 silencing in a cell type-specific manner, in nestin-expressing neural stem cells and glial fibrillary acidic protein-expressing astrocytes...
  15. MOLECULAR MARKERS OF PROGNOSIS IN MEDULLOBLASTOMA
    SANDRA BIGNER; Fiscal Year: 2000
    ..the distribution of synaptophysin, neuron-specific enolase, neurofilament proteins, and glial fibrillary acidic protein, in these specimens...
  16. The Effect of Perinatal Hypoxia on White Matter Astrocytes
    MATTHEW DONALD RAYMOND; Fiscal Year: 2012
    ..I also hypothesize that HX promotes generation of oligodendrocytes from glial fibrillary acidic protein (GFAP)-expressing astrocytes...
  17. Jeffrey L Spees; Fiscal Year: 2015
    ..reactive astrocytes in the peri-infarct area of the cortex, significantly reduced the expression of glial fibrillary acidic protein (GFAP, a marker of activated hypertrophic astrocytes), and significantly increased stroke infarct ..
  18. PHARMACOLOGY OF FETAL STRIATAL TISSUE TRANSPLANTS
    Andrew Norman; Fiscal Year: 1992
    ..We will investigate the presence of astrocytes in the transplant and host brain using the markers for glial fibrillary acidic protein and vimentin which label mature and immature astrocytes respectively...
  19. DIFFERENTIATION AND STROMA-INDUCTION IN NEURAL TUMORS
    LUCIEN RUBINSTEIN; Fiscal Year: 1980
    ....
  20. CYTOKINES AND AIDS DEMENTIA COMPLEX
    Iain Campbell; Fiscal Year: 2000
    ..was employed in which the expression of the cytokines IL-6 and IL-3 was targeted to astrocytes using glial fibrillary acidic protein (GFAP)-fusion gene constructs...
  21. GLIAL ACTIVATION IN AGED MEMORY IMPAIRED RATS
    Kiminobu Sugaya; Fiscal Year: 1999
    ..gene expression for b-amyloid protein precursor (APP), manganese super oxide dismutase (Mn-SOD) and glial fibrillary acidic protein (GFAP) in aged Long-Evans rats...
  22. ETHANOL EFFECTS ON GLIAL RESPONSES TO CNS TISSUE INSULT
    David Davies; Fiscal Year: 1991
    ..The cultures are to be evaluated for glial fibrillary acidic protein immunoreactivity, ultrastructural, and neurotrophic properties...
  23. SECOND MESSENGERS IN ASTROCYTES AND PRECURSOR CELLS
    Bridget Shafit Zagardo; Fiscal Year: 1991
    The goal of this proposal is to understand the role of second messenger systems in the regulation of glial fibrillary acidic protein(GFAP) and in the maturation of bipotential precursor cells from the nervous system in vitro...
  24. Gene engineering of nerve stem using HSV amplicon vector
    Yoshinaga Saeki; Fiscal Year: 2003
    ..will examine five human genes, hypoxanthine-phosphoribosyltransferase, nestin, myelin basic protein, glial fibrillary acidic protein, and microtubule-associated protein tau as a housekeeping, NSC-specific, oligodendrocyte-specific, ..
  25. EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS--INHIBITION OF C
    Scott Barnum; Fiscal Year: 2002
    ..mouse model in which a soluble murine-specific inhibitor, sCrry, is produced by astrocytes using a glial fibrillary acidic protein (GFAP) promoter construct...
  26. Nicotinic Receptors in Glia-Neuron Interactions
    Sukumar Vijayaraghavan; Fiscal Year: 2009
    ..signaling in astrocytes using acute hippocampal slices from mice expressing GFP linked to the glial fibrillary acidic protein (GFAP). Electrophysiological analyses will be carried out examining nicotinic currents on astrocytes...
  27. GENE THERAPY: LYSOSOMAL DISEASES WITH MENTAL RETARDATION
    ROBERT DESNICK; Fiscal Year: 1999
    ..The four Projects will be supported within the Program by three Cores: Administrative (Core A), Laboratory Animal (Core B) and Microscopy (Core C). ..
  28. BRAIN MACROPHAGES AND REPRODUCTIVE AGING
    Frederick Naftolin; Fiscal Year: 2002
    ..immunolabeling for the neuronal marker microtubule-associated protein 2 (MAP 2), the astroglia marker glial fibrillary acidic protein (GFAP), the macrophage marker OX42, and, the appearance of a cell adhesion molecule 1 (I-CAM-1) to ..
  29. The Role of C3 and C3 receptors in Experimental Autoimmune Encephalomyelitis
    Scott Barnum; Fiscal Year: 2007
    ..In the latter C3a is expressed in the CNS under the control of a glial fibrillary acidic protein (GFAP) promoter...
  30. STUDIES ON THE IMMUNOPATHOLOGY OF MULTIPLE SCLEROSIS
    UTE TRAUGOTT; Fiscal Year: 1990
    ..Cultured human astrocytes and oligodendrocytes will be employed to study lymphokine-induced MHC expression and involvement in antigen presentation...
  31. Hippocampal atrophy in major depression
    Craig Stockmeier; Fiscal Year: 2007
    ..In Aim 3, the density and size of glial fibrillary acidic protein (GFAP) -immunoreactive cell bodies, and the areal fraction occupied by GFAP-immunoreactivity in ..
  32. NERVE GROWTH FACTOR AND OROFACIAL NEUROPATHIC PAIN
    Leigh Anderson; Fiscal Year: 2001
    ..activity and conduction velocity), and ganglionic cytochemistry (CGRP, tyrosine hydroxylase, c-jun, glial fibrillary acidic protein, p75 and trkA NGF receptors and brain derived neurotrophic factor) in the ipsilateral and ..
  33. Analysis of Genomic and Proteomic Changes in Glia That Lead To Hydrocephalus
    Ken McCarthy; Fiscal Year: 2009
    ..of HC, referred to as Ro1HC, is based on the over expression of a Gi coupled GPCR in cells expressing glial fibrillary acidic protein (GFAP)...
  34. ACETYLCHOLINESTERASE & CHOLINERGIC NEURONS IN THE BRAIN
    LARRY BUTCHER; Fiscal Year: 1992
    ..other compounds, (2) immunohistochemical demonstration of choline acetyltransferase, NGF receptor, glial fibrillary acidic protein, and cytoskeletal proteins, (3) histochemical and histologic processing for acetylcholinesterase, ..
  35. UNIQUE GLIAL CELL POPULATION IN THE BRAIN
    Akiko Nishiyama; Fiscal Year: 1999
    ..appears to be distinct from microglia, mature oligodendrocyte, or mature astrocytes that express glial fibrillary acidic protein (GFAP). The specific aims of this proposal are designed to address the following questions: 1...
  36. MICHAEL JOSEPH BARRESI; Fiscal Year: 2015
    ..since the time of Cajal, but over the last few decades the increase of available markers particularly glial fibrillary acidic protein has made their identification as astroglial cells increasingly easier...
  37. Neuroprotective Properties of Enhanced Glutamate Uptake
    Margaret Sutherland; Fiscal Year: 2005
    ..Transgene expression is driven by the astrocyte-specific glial fibrillary acidic protein (GFAP) promoter and results in a 3-5 fold increase in synaptosomal, hippocampal, cerebrocortical and ..
  38. GLIAL CELL SIGNALING IN CENTRAL NERVOUS SYSTEM INJURY
    Andrew Charles; Fiscal Year: 1999
    ..with changes in membrane potential, cell volume, cell morphology, cell viability, and expression of glial fibrillary acidic protein in astrocytes...
  39. Analyses and Applications of GFAP Transcription
    Michael Brenner; Fiscal Year: 2010
    ..We are approaching this goal by studying the transcriptional regulation of the gene encoding glial fibrillary acidic protein (GFAP), an astrocyte-specific protein whose synthesis is greatly increased during the reactive ..
  40. TRANSGENIC MODELS FOR NEUROTOXICITY AND DNA REPAIR
    MELVIN BILLINGSLEY; Fiscal Year: 1999
    ..project, transgenic mice will be developed in which reporter genes will be inserted under control of glial fibrillary acidic protein (GFAP) promoter elements...
  41. DEVELOPMENTAL EXPRESSION OF NOVOCANS
    Sara Szuchet; Fiscal Year: 2002
    ..in rat brains, using monoclinal antibodies (mass) against NOVOCAIN and either a polyclonal anti-GFAP (glial fibrillary acidic protein), revealed (mostly) co-localization with M.P. but not GFAP (but see below)...
  42. NEUROFIBROMIN AS A NEGATIVE REGULATOR FOR ASTROCYTES
    David Gutmann; Fiscal Year: 2002
    ..it was demonstrated that mice heterozygous for a targeted NF1 gene mutation have increased numbers of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in their brains...
  43. MOLECULAR THERAPEUTICS FOR HIV COGNITIVE DYSFUNCTION
    Bassel Sawaya; Fiscal Year: 2003
    ..Toward this end, we will utilize the tissue specific promoters, macrosialin and glial fibrillary acidic protein (GFAP), in order to target gene expression to microglia and astrocytes, respectively.
  44. CHARACTERIZATION OF NEURAL STEM CELLS IN THE ADULT BRAIN
    Arturo Alvarez Buylla; Fiscal Year: 2007
    ..Type B cells have the structure of astrocytes and express glial fibrillary acidic protein (GFAP)...
  45. MOLECULAR AND CELLULAR RESPONSES OF BRAIN TO IRRADIATION
    William McBride; Fiscal Year: 1999
    ..Strategies for therapeutic intervention to increase the effectiveness of radiotherapy for brain cancer might be generated as a result of this study. ..
  46. MOUSE MODELS FOR HTLV-1 INDUCED PATHOGENESIS
    Michael Nerenberg; Fiscal Year: 1993
    ..by use of the rat neuron specific enolase promoter and specifically to astrocytes by the murine glial fibrillary acidic protein promoter...
  47. BRAIN SPECIFIC PROTEIN--GFA PROTEIN IN ASTROCYTES
    AMICO BIGNAMI; Fiscal Year: 1993
    ..Conversely, other hyaluronate-binding fractions co-localized in brain and mesenchyma during embryonal development...
  48. A New Tool for Targeted Antisense Knockdown in Brain
    Robert Gibbs; Fiscal Year: 2006
    ..conjugates on cell viability using standard Nissl stain, as well as immunohistochemical detection of glial fibrillary acidic protein, and histochemical detection of microglial infiltration...
  49. Opiate's Effects on the Inflammation and Cytotoxicity in HIV-1 Transgenic Rat
    SULIE CHANG; Fiscal Year: 2007
    ..HIV-1-induced cytotoxicity in vivo by measuring changes in neurons (NeuN-labeled cells), astrocytes (glial fibrillary acidic protein-labeled cells), and synapses (using synaptophsin and SNAP-25 to identify synapses) in combination ..
  50. CELLULAR CORRELATES OF AXONAL SPROUTING
    CHARLES PADEN; Fiscal Year: 1992
    ..of macrophage-specific antigens by glial cells of the NL; (3) determine if altered expression of glial fibrillary acidic protein, vimentin, and glial hyaluronate-binding protein by pituicytes accompanies sprouting; and (4), ..
  51. PATHOGENESIS AND TREATMENT OF MULTIPLE SCLEROSIS
    MURRAY BORNSTEIN; Fiscal Year: 1990
    ..Core A- will supply organtoypic cultures for this program and, in addition, will establish cultures of endothelial cells and CNS tissue...
  52. INHIBITION OF CPB-MEDIATED NEUROLOGICAL DYSFUNCTION
    Suzanne McKenna; Fiscal Year: 2004
    ..have undergone CPB: neuromotor functioning, rotorod test, Morris Water Maze task, and fluoro-jade and glial fibrillary acidic protein staining of the hippocampus to examine degenerating neurons and astrocyte proliferation, respectively...
  53. COCAINE AND BRAIN DEVELOPMENT
    James West; Fiscal Year: 1993
    ..b>Glial fibrillary acidic protein (GFAP) immunocytochemistry will be used to identify affected regions throughout the brain...
  54. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  55. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  56. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  57. MICROARRAY ANALYSIS OF RETINAL DEGENERATION IN MICE
    Caroline Zeiss; Fiscal Year: 2007
    ..Colin Barnstable, Professor of Neurobiology and Ophthalmology, who is an internationally recognized molecular biologist using mouse models of retinal development and degeneration. ..
  58. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  59. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  60. FUNCTION OF GFAP IN ASTROCYTE DEVELOPMENT AND DISEASE
    Albee Messing; Fiscal Year: 2002
    DESCRIPTION (Adapted from applicant's abstract): Glial fibrillary acidic protein (GFAP) is one of the major structural proteins in astrocytes, and its expression is markedly up-regulated following injury...
  61. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  62. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..abstract_text> ..
  63. Neurogenesis in the Human Brain
    Alfredo Quinones Hinojosa; Fiscal Year: 2003
    ....