carboxymethylcellulose

Summary

Summary: A cellulose derivative which is a Beta-(1->4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.

Top Publications

  1. ncbi Anaphylactic shock after intra-articular injection of carboxymethylcellulose
    J Montoro
    Al lergo Centre, Barcelona, Spain
    Allergol Immunopathol (Madr) 28:332-3. 2000
  2. ncbi Comparison of a novel liquid (Adcon-P) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) in postsurgical adhesion formation in a murine model
    Mustafa Oncel
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Dis Colon Rectum 46:187-91. 2003
  3. ncbi Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps
    D Prabakaran
    Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour University, Sagar, MP 470 003, Sagar, India
    Int J Pharm 259:173-9. 2003
  4. ncbi Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomized, evaluator-blinded multicenter study
    Zane Cohen
    Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Dis Colon Rectum 48:1130-9. 2005
  5. ncbi Microplate-based carboxymethylcellulose assay for endoglucanase activity
    Zhizhuang Xiao
    Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montreal, Que, Canada H4B 1R6
    Anal Biochem 342:176-8. 2005
  6. pmc Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in
    Hideho Okada
    G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    J Clin Oncol 29:330-6. 2011
  7. pmc Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
    Marina Caskey
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:2357-66. 2011
  8. ncbi Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs
    A E Clausen
    Centre of Pharmacy, Institute of Pharmaceutical Technology and Biopharmaceutics, University of, Vienna, Austria
    Eur J Pharm Biopharm 51:25-32. 2001
  9. ncbi Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Pharm 389:24-31. 2010
  10. ncbi Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models
    Mark J Ernsting
    Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Biomaterials 33:1445-54. 2012

Detail Information

Publications245 found, 100 shown here

  1. ncbi Anaphylactic shock after intra-articular injection of carboxymethylcellulose
    J Montoro
    Al lergo Centre, Barcelona, Spain
    Allergol Immunopathol (Madr) 28:332-3. 2000
    Sodium carboxymethylcellulose (SCMC) is the sodium salt of a polycarboxymethyl ether of cellulose. SCMC is widely used in pharmaceutical and food industries...
  2. ncbi Comparison of a novel liquid (Adcon-P) and a sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) in postsurgical adhesion formation in a murine model
    Mustafa Oncel
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Dis Colon Rectum 46:187-91. 2003
    ..This study aimed to compare the effectiveness of a novel liquid antiadhesive barrier with a conventional sheet (Seprafilm) antiadhesive barrier in a murine cecal abrasion model...
  3. ncbi Effect of hydrophilic polymers on the release of diltiazem hydrochloride from elementary osmotic pumps
    D Prabakaran
    Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr Harisingh Gour University, Sagar, MP 470 003, Sagar, India
    Int J Pharm 259:173-9. 2003
    ..Criteria for selecting the most appropriate model were based on best goodness of fit and smallest sum of squared residuals...
  4. ncbi Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomized, evaluator-blinded multicenter study
    Zane Cohen
    Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Dis Colon Rectum 48:1130-9. 2005
    ..a bioresorbable membrane containing up to 23 percent glycerol and chemically modified sodium hyaluronate/carboxymethylcellulose offers ease of handling and has been shown to provide significant postoperative adhesion prevention in ..
  5. ncbi Microplate-based carboxymethylcellulose assay for endoglucanase activity
    Zhizhuang Xiao
    Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montreal, Que, Canada H4B 1R6
    Anal Biochem 342:176-8. 2005
  6. pmc Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in
    Hideho Okada
    G12 a Research Pavilion at the Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213 1863, USA
    J Clin Oncol 29:330-6. 2011
    ..GAA) epitopes and administration of polyinosinic-polycytidylic acid [poly(I:C)] stabilized by lysine and carboxymethylcellulose (poly-ICLC) in HLA-A2(+) patients with recurrent malignant gliomas...
  7. pmc Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
    Marina Caskey
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:2357-66. 2011
    ..Therefore, a chemically defined PRR agonist like poly ICLC can be a reliable and authentic microbial mimic for inducing innate immune responses in humans...
  8. ncbi Thiolated carboxymethylcellulose: in vitro evaluation of its permeation enhancing effect on peptide drugs
    A E Clausen
    Centre of Pharmacy, Institute of Pharmaceutical Technology and Biopharmaceutics, University of, Vienna, Austria
    Eur J Pharm Biopharm 51:25-32. 2001
    The purpose of this study was to evaluate the effect of sodium carboxymethylcellulose (NaCMC) and carboxymethylcellulose-cysteine (CMC-Cys) conjugates on the intestinal permeation of sodium fluorescein (NaFlu) and model peptide drugs, ..
  9. ncbi Characterisation of freeze-dried wafers and solvent evaporated films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Pharm 389:24-31. 2010
    Freeze-dried (lyophilised) wafers and solvent cast films from sodium alginate (ALG) and sodium carboxymethylcellulose (CMC) have been developed as potential drug delivery systems for mucosal surfaces including wounds...
  10. ncbi Preclinical pharmacokinetic, biodistribution, and anti-cancer efficacy studies of a docetaxel-carboxymethylcellulose nanoparticle in mouse models
    Mark J Ernsting
    Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Ontario Institute for Cancer Research, Toronto, Ontario, Canada
    Biomaterials 33:1445-54. 2012
    We have developed a polymer conjugate (Cellax) composed of acetylated carboxymethylcellulose (CMC), docetaxel (DTX), and PEG, designed to enhance the pharmacokinetics (PK) and antitumor efficacy of DTX...
  11. ncbi Experimental model of knee contracture in extension: its prevention using a sheet made from hyaluronic acid and carboxymethylcellulose
    M Hayashi
    Orthopaedic Department, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Kawachi gun, Tochigi 329 0498, Japan
    Knee Surg Sports Traumatol Arthrosc 12:545-51. 2004
    ..The usage of HA/CMC sheet should be effective for prevention of contracture occurring after trauma such as treatment for intra-articular fracture...
  12. ncbi Effect of carboxymethylcellulose nasal packing on wound healing after functional endoscopic sinus surgery
    Konrad G Kastl
    Department of Otorhinolaryngology, University Hospital Ulm, Ulm, Germany
    Am J Rhinol Allergy 23:80-4. 2009
    ..The purpose of this study was to investigate the effect of carboxy-methylated cellulose (CMC) nasal packing on wound healing after FESS compared with no nasal packing...
  13. ncbi A sprayable hyaluronate/carboxymethylcellulose adhesion barrier exhibits regional adhesion reduction efficacy and does not impair intestinal healing
    Holly K Sheldon
    Department of Surgery, Boston University Medical Center, 88 East Newton Street, C 500, Boston, MA 02118, USA
    J Gastrointest Surg 16:325-33. 2012
    ..The aim of this study was to assess the effectiveness of the sprayable adhesion barrier Sepraspray® in preventing adhesions to sites of direct application and to remote sites...
  14. ncbi Characterization of novel photocrosslinked carboxymethylcellulose hydrogels for encapsulation of nucleus pulposus cells
    Anna T Reza
    Department of Bioengineering, University of Pennsylvania, Room 240 Skirkanich Hall, 210 S 33rd Street, Philadelphia, PA 19104, USA
    Acta Biomater 6:179-86. 2010
    ..One candidate material is carboxymethylcellulose (CMC), a water-soluble derivative of cellulose...
  15. ncbi Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Drug Dev Ind Pharm 35:986-96. 2009
    Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air...
  16. ncbi Sodium carboxymethylcellulose scaffolds and their physicochemical effects on partial thickness wound healing
    Nor Amlizan Ramli
    Universiti Teknologi MARA, 42300, Puncak Alam, Selangor, Malaysia
    Int J Pharm 403:73-82. 2011
    ..critical physicochemical attributes of low (LV), medium (MV) and high molecular weight (HV) sodium carboxymethylcellulose (SCMC) scaffolds in partial thickness wound healing...
  17. ncbi Tumor-targeted drug delivery using MR-contrasted docetaxel - carboxymethylcellulose nanoparticles
    Mark J Ernsting
    Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Ontario Institute for Cancer Research, MaRS Centre South Tower, Toronto, Ontario M5G 0A3, Canada
    Biomaterials 33:3931-41. 2012
    A carboxymethylcellulose-based polymer conjugate with nanoparticle forming properties (Cellax) has been shown to enhance the pharmacokinetics, specificity of biodistribution, anti-tumor efficacy and safety of docetaxel (DTX) in comparison ..
  18. ncbi In vitro drug release studies of polymeric freeze-dried wafers and solvent-cast films using paracetamol as a model soluble drug
    Joshua S Boateng
    Department of Pharmaceutical Sciences, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, John Arbuthnott Building, 27 Taylor Street, Glasgow G4 0NR, UK
    Int J Pharm 378:66-72. 2009
    ..and release characteristics from freeze-dried wafers and solvent-cast films prepared from sodium carboxymethylcellulose (CMC) have been investigated to determine the mechanisms of drug release from the two systems...
  19. ncbi Prevention of adhesion formation after radical oophorectomy using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier
    Robert E Bristow
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Phipps 281, Baltimore, MD 21287, USA
    Gynecol Oncol 99:301-8. 2005
    To evaluate the efficacy of a hyaluronate-carboxymethylcellulose (HA-CMC) barrier for prevention of pelvic adhesion formation in women undergoing primary cytoreductive surgery with radical oophorectomy for locally advanced epithelial ..
  20. ncbi Comparative effectiveness of several agents for preventing postoperative adhesions
    Jehat Kutlay
    2nd General Surgery Department, SSK Ankara Teaching Hospital, Ankara 06090, Turkey
    World J Surg 28:662-5. 2004
    ..001, p = 0.017, p < 0.001, respectively). Intraperitoneal SCMC and administration of LMWH were more effective than giving aprotinin...
  21. ncbi Identification of cellulase genes from the metagenomes of compost soils and functional characterization of one novel endoglucanase
    Hao Pang
    Guangxi Key Laboratory of Subtropical Bioresources Conservation and Utilization, College of Life Science and Technology, Guangxi University, Nanning, Guangxi, People s Republic of China
    Curr Microbiol 58:404-8. 2009
    ..The recombinant protein, Umcel9B, showed activity against carboxymethyl cellulose, indicating that Umcel9B is an endoactive enzyme. Enzymatic activity occurs optimally at a pH of 7.0 and a temperature of 25 degrees C...
  22. ncbi Prevention of peritendinous adhesions following flexor tendon injury with seprafilm
    Adnan Menderes
    Dokuz Eylul University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Izmir, Turkey
    Ann Plast Surg 53:560-4. 2004
    ..As a result, it was concluded that in rabbit the peritendinous adhesions following flexor tendon repairs could be lowered with Seprafilm and hyaluronic acid...
  23. ncbi A novel OCT technique to measure in vivo the corneal adhesiveness for sodium carboxymethylcellulose in humans and its validity in the diagnosis of dry eye
    Pietro Emanuele Napoli
    Department of Surgical Sciences, Eye Clinic, University of Cagliari, Cagliari, Italy
    Invest Ophthalmol Vis Sci 55:3179-85. 2014
    ....
  24. ncbi Swellable drug-polyelectrolyte matrices of drug-carboxymethylcellulose complexes. Characterization and delivery properties
    María V Ramírez Rigo
    Departamento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Cordoba, Argentina
    Drug Deliv 16:108-15. 2009
    ..delivery properties of swellable drug-polyelectrolyte matrices prepared with complexes of the acid form of carboxymethylcellulose (HCMC)...
  25. ncbi Carboxymethylcellulose as a new carrier substance for intravitreal injection of reproducible amounts of triamcinolone
    T Kube
    Department of Ophthalmology, University of Freiburg, Killianstrasse 5, 79106 Freiburg, Germany
    Graefes Arch Clin Exp Ophthalmol 244:1385-90. 2006
    ..The aim of this study was to find a safe vehicle that would allow intravitreal injection of an exact amount of triamcinolone acetonide without potentially retinotoxic preservatives...
  26. ncbi Protection of trocar sites from gallbladder cancer implantation by sodium hyaluronate carboxymethylcellulose-based bioresorbable membrane (Seprafilm) in a murine model [corrected]
    T Sasaki
    First Department of Surgery, Fukuoka University School of Medicine, Nanakuma 7 45 1, Jonan ku, Fukuoka, 814 0180, Japan
    Surg Endosc 18:246-51. 2004
    ..We examined the protective effect of a sodium hyaluronate-based bioresorbable membrane (Seprafilm) on tumor cell implantation at laparoscopic trocar sites...
  27. ncbi Calcium sulfate-carboxymethylcellulose bone graft binder: Histologic and morphometric evaluation in a critical size defect
    Mark A Reynolds
    Department of Periodontics, University of Maryland, Dental School, Baltimore, Maryland, USA
    J Biomed Mater Res B Appl Biomater 83:451-8. 2007
    Calcium sulfate (CS) is widely used as a bone graft binder and expander. Recent reports indicate that carboxymethylcellulose (CMC) can improve the clinical properties of CS when used as binder for particulate bone grafts; however, limited ..
  28. pmc The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways
    Uta Griesenbach
    Department of Gene Therapy, Imperial College at the National Heart and Lung Institute, London SW3 6LR, UK
    Biomaterials 31:2665-72. 2010
    ..Methylcellulose or carboxymethylcellulose (0.25-1...
  29. ncbi Rapamycin and a hyaluronic acid-carboxymethylcellulose membrane did not lead to reduced adhesion formations in a rat abdominal adhesion model
    Arne Dietrich
    Clinic for Abdominal, Vascular, Thoracic and Transplant Surgery, Chirurgische Klinik II, Leipzig University, Liebigstr 18, 04103 Leipzig, Germany
    Arch Gynecol Obstet 285:1603-9. 2012
    ..Rapamycin, an immunosuppressive in transplant surgery, has an additional antiproliferative effect. The aim of this study was to investigate the potential protective effects of rapamycin on postoperative adhesion development...
  30. ncbi Effect of a mixed solution of sodium hyaluronate and carboxymethyl cellulose on upper limb dysfunction after total mastectomy: a double-blind, randomized clinical trial
    Eun Joo Yang
    Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea
    Breast Cancer Res Treat 136:187-94. 2012
    ..These results provide evidence that HA-CMC may provide pain relief and improve ROM of the shoulder without causing adverse effects. The effect on pectoralis tightness should be investigated in further studies...
  31. ncbi Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells
    Alexandru Mihai Grumezescu
    University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, Department of Science and Engineering of Oxidic Materials and Nanomaterials, Polizu Street no 1 7, 011061 Bucharest, Romania
    Int J Pharm 436:771-7. 2012
    ..The obtained systems are not cytotoxic and do not influence the eukaryotic HCT8 cell cycle, representing potential tools for the delivery of drugs in a safe, effective and less expensive manner...
  32. ncbi Utilization and safety of sodium hyaluronate-carboxymethylcellulose adhesion barrier
    Shazia Bashir
    1 Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 2 Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 3 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 4 Herbert Irving Comprehensive Cancer Center, New York, New York
    Dis Colon Rectum 56:1174-84. 2013
    Little is known about the use and toxicity of antiadhesion substances such as sodium hyaluronate-carboxymethylcellulose.
  33. ncbi Analysis of postoperative complications associated with the use of anti-adhesion sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier after cytoreductive surgery for ovarian, fallopian tube and peritoneal cancers
    Lauren S Krill
    The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Gynecol Oncol 120:220-3. 2011
    ..To evaluate the risk of postoperative complications related to HA-CMC use in patients undergoing optimal cytoreductive surgery for primary and recurrent ovarian, fallopian tube, and peritoneal cancers...
  34. ncbi Treatment of recurrent sinonasal polyposis with steroid-infused carboxymethylcellulose foam
    Steven D Pletcher
    Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, 2233 Post Street, San Francisco, CA 94115, USA
    Am J Rhinol Allergy 24:451-3. 2010
    ..This study was designed to evaluate the efficacy of steroid-infused carboxymethylcellulose (CMC) foam as a treatment for recurrence of chronic rhinosinusitis with nasal polyposis after endoscopic ..
  35. ncbi Postoperative intra-abdominal collections using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier at the time of laparotomy for uterine or cervical cancers
    Mario M Leitao
    Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Gynecol Oncol 119:208-11. 2010
    ..The primary objective of the current study was to determine whether the use of HA-CMC is associated with the development of postoperative intra-abdominal collections in patients undergoing laparotomy for uterine or cervical malignancies...
  36. ncbi Carboxymethylcellulose-stabilized collagenous rhOP-1 device-a novel carrier biomaterial for the repair of mandibular continuity defects
    Huiming Wang
    Department of Oral and Maxillofacial Surgery, University of Kiel, Kiel, Germany
    J Biomed Mater Res A 68:219-26. 2004
    ..We hypothesized that the addition of carboxymethylcellulose (CMC) may stabilize the device and facilitate the regeneration of mandibular continuity defects without ..
  37. ncbi An amidated carboxymethylcellulose hydrogel for cartilage regeneration
    Gemma Leone
    Department of Chemical and Biosystem Sciences and Technologies and C R I S M A, University of Siena, Via A Moro N 2, Siena 53100, Italy
    J Mater Sci Mater Med 19:2873-80. 2008
    An amidic derivative of carboxymethylcellulose was synthesized (CMCA)...
  38. ncbi A randomized, multi-center, clinical trial to assess the efficacy and safety of alginate carboxymethylcellulose hyaluronic acid compared to carboxymethylcellulose hyaluronic acid to prevent postoperative intrauterine adhesion
    Tak Kim
    Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, South Korea
    J Minim Invasive Gynecol 19:731-6. 2012
    To estimate the efficacy of alginate carboxymethylcellulose hyaluronic acid (ACH) gel to prevent intrauterine adhesions after hysteroscopic surgery in comparison with carboxymethylcellulose hyaluronic acid (CH) gel, which is known as an ..
  39. ncbi Comparison of human amniotic membrane and hyaluronate/carboxymethylcellulose membrane for prevention of adhesion formation in rats
    Sefa Kelekci
    Department of Obstetrics and Gynecology, Zekai Tahir Burak Women s Health Education and Research Hospital, Ankara, Turkey
    Arch Gynecol Obstet 276:355-9. 2007
    To investigate the effectiveness of human amniotic membrane (HAM) in the prevention of postoperative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose (HA/CMC) membrane in a rat model.
  40. ncbi Loading and in vitro controlled release of indomethacin using amphiphilic cholesteryl-bearing carboxymethylcellulose derivatives
    Liqun Yang
    Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, China
    Macromol Biosci 8:279-86. 2008
    ..The CCMC micelles showed pH-responsive behavior during the drug-loading and release processes. CCMC is promising as a potential delivery system for the controlled release of IND with a pH-responsive property...
  41. ncbi Immobilizing Cu,Zn-superoxide dismutase in hydrogels of carboxymethylcellulose improves its stability and wound healing properties
    A Chiumiento
    CRISMA Department of Chemical and Biosystem Sciences and Technologies, University of Siena, Siena, 53100, Italy
    Biochemistry (Mosc) 71:1324-8. 2006
    Hydrogels of carboxymethylcellulose (CMC) with 50 and 90% cross-linking degree (CMC50% and CMC90%, respectively) were prepared and loaded with bovine erythrocyte Cu,Zn-superoxide dismutase (SOD) to obtain two drug delivery systems: SOD-..
  42. ncbi Effect of carboxymethylcellulose and hyaluronate solutions on jejunal healing in horses
    Randy B Eggleston
    Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Am J Vet Res 65:637-43. 2004
    ..inverting anastomosis with a single-layer appositional anastomosis, coated with either 1% sodium carboxymethylcellulose (SCMC) or 0...
  43. ncbi Evaluation of a sheep laparoscopic uterine trauma model and repeat laparoscopy for evaluation of adhesion formation and prevention with sodium carboxymethylcellulose
    Jennifer M Ewoldt
    Departments of Veterinary Clinical Sciences and Veterinary Biosciences, The Ohio State University, Columbus, OH, USA
    Vet Surg 33:668-72. 2004
    ..To evaluate topical application of 1% sodium carboxymethyl cellulose (SCMC) for prevention of postoperative adhesions in a laparoscopic model of uterine trauma in sheep...
  44. ncbi A novel method of endoscopic submucosal dissection with blunt abrasion by submucosal injection of sodium carboxymethylcellulose: an animal preliminary study
    Masahiro Yamasaki
    Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyusyu, Japan
    Gastrointest Endosc 64:958-65. 2006
    ..Submucosal injection of a viscous substance, eg, jelly, obviates the need of submucosal incision with a knife. Sodium carboxymethylcellulose (SCMC), known as cellulose gum, is highly viscous when dissolved in water.
  45. ncbi Does carboxymethylcellulose have a role in reducing time to full enteral feeds in preterm neonates?
    S K Patole
    Department of Neonatology, James Cook University, Townsville, Australia
    Int J Clin Pract 59:544-8. 2005
    The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial...
  46. ncbi A sodium hyaluronate carboxymethylcellulose bioresorbable membrane prevents postoperative small-bowel adhesive obstruction after distal gastrectomy
    Hideki Kawamura
    Department of Surgery, JA Sapporo Kosei Hospital, N3, E8, Chuo Ku, Sapporo, 060 0033, Japan
    Surg Today 40:223-7. 2010
    ..Thus, it is an appropriate operation to test the efficiency of a synthetic absorbable adhesion barrier (Seprafilm)...
  47. ncbi Study of the critical points of experimental HPMC-NaCMC hydrophilic matrices
    L Contreras
    Department of Pharmacy and Pharmaceutical Technology, University of Seville, 41012 Seville, Spain
    Int J Pharm 386:52-60. 2010
    ..The knowledge of this critical barrier will be useful in order to optimize the design of the ternary hydrophilic matrix systems...
  48. ncbi Impact of carboxymethylcellulose on morphology and antibiotic production by Streptomyces hygroscopicus
    Slavica B Ilić
    Faculty of Technology, Bulevar oslobodjenja 124, Leskovac, Yugoslavia
    Curr Microbiol 57:8-11. 2008
    A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7...
  49. ncbi A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases
    Mark J Ernsting
    Drug Delivery and Formulation, Medicinal Chemistry Platform, Ontario Institute for Cancer Research, 101 College Street, Suite 800, Toronto, Ontario M5G 0A3, Canada
    J Control Release 162:575-81. 2012
    Cellax is a PEGylated carboxymethylcellulose conjugate of docetaxel (DTX) which condenses into a 120-nm nanoparticle, and was compared against the approved clinical taxane nanoformulation (Abraxane®) in mouse models...
  50. ncbi Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model
    M Lalountas
    Laboratory of Scientific Research and Experimental Surgery, Second Propedeutical Department of Surgery, Medical School, Aristotle University, and Hippokration General Hospital, Thessaloniki, Greece
    Br J Surg 99:423-9. 2012
    ..this study was to compare the effectiveness of Statofilm, a novel antiadhesive film based on cross-linked carboxymethylcellulose and atorvastatin, with that of sodium hyaluronate-carboxymethylcellulose (Seprafilm(®)) in the prevention ..
  51. ncbi Use of a high-molecular-weight carboxymethylcellulose in a tissue protective solution for prevention of postoperative abdominal adhesions in ponies
    David J Murphy
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Am J Vet Res 63:1448-54. 2002
    To evaluate efficacy and safety of IP administration of high-molecular-weight carboxymethylcellulose (HMW CMC) for the prevention of postoperative intra-abdominal adhesions in ponies.
  52. ncbi Analysis of sodium carboxymethylcellulose administration and related factors associated with postoperative colic and survival in horses with small intestinal disease
    Callie A Fogle
    Department of Clinical Sciences and Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA
    Vet Surg 37:558-63. 2008
    To analyze the effect of the intraoperative use of sodium carboxymethylcellulose (CBMC) and related perioperative factors on postoperative colic and survival in horses that had abdominal surgery for colic.
  53. ncbi Bacterial overgrowth and inflammation of small intestine after carboxymethylcellulose ingestion in genetically susceptible mice
    Alexander Swidsinski
    Humboldt University, Charite Hospital, Laboratory for Molecular Genetics, Polymicrobial Infections and Bacterial Biofilms, 10098 Berlin, Germany
    Inflamm Bowel Dis 15:359-64. 2009
    ..We investigated the influence of 2% carboxymethylcellulose (CMC) on the biostructure of the intestinal microbiota in IL-10 gene-deficient mice.
  54. ncbi Reduction in adhesive small-bowel obstruction by Seprafilm adhesion barrier after intestinal resection
    Victor W Fazio
    Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 49:1-11. 2006
    ..Although Seprafilm has been demonstrated to reduce adhesion formation, it is not known whether its usage would translate into a reduction in adhesive small-bowel obstruction...
  55. ncbi Clinical performance of a mid-viscosity artificial tear for dry eye treatment
    Peter A Simmons
    Eye Care Research and Development, Allergan LLC, Irvine, CA 92612, USA
    Cornea 26:294-302. 2007
    We report the results of 3 studies conducted to evaluate the performance of a 1.0% carboxymethylcellulose (CMC) mid-viscosity artificial tear compared to currently marketed low-viscosity tears.
  56. ncbi Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose
    Jinichi Fukami
    Kyoto Pharmaceutical Industries Ltd, 38 Nishinokyo, Kyoto 604 8444, Japan
    Int J Pharm 310:101-9. 2006
    ..Wetting time prepared from carboxymethylcellulose (NS-300) having the hardness of 4 kg was 3 s...
  57. ncbi Efficacy of antiadhesion barrier solution on periimplant capsule formation in a white rat model
    Dae Hyun Lew
    Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea
    Ann Plast Surg 65:254-8. 2010
    ..It also made the collagen fibers in the capsule loose and parallel. Therefore, AABS seemed to be effective in reducing the periimplant capsule formation...
  58. ncbi Novel synthetic dermal fillers based on sodium carboxymethylcellulose: comparison with crosslinked hyaluronic acid-based dermal fillers
    Samuel J Falcone
    FzioMed Inc, San Luis Obispo, California 93401, USA
    Dermatol Surg 33:S136-43; discussion S143. 2007
    ..For dermal fillers composed of XLHA, a polymer concentration above approximately 25 mg/mL is not practical because it cannot be easily injected through a small-bore needle...
  59. ncbi Aquacel Ag in the management of partial-thickness burns: results of a clinical trial
    Daniel M Caruso
    Maricopa Medical Center, Phoenix, Arizona 85008, USA
    J Burn Care Rehabil 25:89-97. 2004
    ..Overall, Aquacel Ag combines several properties known to be beneficial for the management of partial-thickness burns and is a very good choice for superficial and mid-thickness burn injuries...
  60. ncbi Polymeric films as vehicle for buccal delivery: swelling, mechanical, and bioadhesive properties
    K K Peh
    School of Pharmaceutical Sciences, University of Science Malaysia, Penang, Malaysia
    J Pharm Pharm Sci 2:53-61. 1999
    ..To investigate the suitability of an SCMC (sodium carboxymethyl cellulose/polyethylene glycol 400/carbopol 934P) and an HPMC (hydroxypropylmethyl cellulose/polyethylene glycol 400/carbopol 934P) films as drug vehicle for buccal delivery...
  61. pmc A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma
    Myrna R Rosenfeld
    Department of Neurology, 3 W Gates, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Neuro Oncol 12:1071-7. 2010
    ..to determine the safety and efficacy of polyinosinic-polycytidylic acid stabilized with poly-l-lysine and carboxymethylcellulose (poly-ICLC) when added to radiation and temozolomide (TMZ) in adults with newly diagnosed glioblastoma (GB)..
  62. ncbi Development of biodegradable aluminium carboxymethylcellulose matrices for mosquito larvicides
    Nisha Mathew
    Vector Control Research Centre ICMR Pondicherry 605 006, India
    Pest Manag Sci 60:685-90. 2004
    ..Among the 20 matrices developed by entrapping the organophosphorus mosquito larvicide, fenthion, in carboxymethylcellulose ionotropically cross-linked with aluminium ions which were studied for release profiles, two matrices, ..
  63. ncbi Preventing intraperitoneal adhesions with vitamin E and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats
    Fredy Corrales
    HG, UCS, Caxias do Sul, Brazil
    Acta Cir Bras 23:36-41. 2008
    To compare the effectiveness of intraperitoneally administered vitamin E with the sodium hyaluronate/carboxymethylcellulose membrane (HA/CBMC) in preventing postoperative intraperitoneal adhesion formation.
  64. ncbi Effects of a hyaluronate-carboxymethylcellulose membrane (Seprafilm) on human polymorphonuclear neutrophil functions
    Kohei Otake
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan
    J Surg Res 149:243-9. 2008
    ..The present study evaluates the effect of Seprafilm itself on human PMNs in experimental models in vitro...
  65. ncbi Release of liposome-encapsulated calcein from liposome entrapping gelatin-carboxymethylcellulose films: a presentation of different possibilities
    Catalina Peptu
    Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26510, Greece
    J Nanosci Nanotechnol 8:2249-58. 2008
    Liposome entrapment in films consisting of gelatin (GEL) or GEL/sodium carboxymethylcellulose (NaCMC) mixtures, as a method to alter drug release kinetics from polymeric films and/or incorporate sensitive bioactive molecules in solid ..
  66. doi Allergic contact dermatitis to carboxymethylcellulose in Comfeel hydrocolloid dressing
    Florence Pasche Koo
    Department of Dermatology, Geneva University Hospital, 1211 Geneva 4, Switzerland
    Contact Dermatitis 58:375-6. 2008
  67. ncbi Effect of various calcium/phosphates ratios of carboxymethylcellulose-based saliva substitutes on mineral loss of bovine enamel in vitro
    Hendrik Meyer-Lueckel
    Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Campus Benjamin Franklin, Charite Universitatsmedizin Berlin, Germany
    J Dent 35:851-7. 2007
    The present study evaluated the effects of various calcium and phosphate concentrations and ratios of carboxymethylcellulose (CMC)-based solutions on the mineral loss of predemineralised bovine enamel in vitro.
  68. ncbi Effect of carboxymethylcellulose-based saliva substitutes on predemineralised dentin evaluated by microradiography
    P Tschoppe
    Department of Operative Dentistry and Periodontology, CharitéCentrum for Dental Medicine, Charite Universitatsmedizin Berlin, Assmannshauser Strasse 4 6, Berlin, Germany
    Arch Oral Biol 53:250-6. 2008
    This study investigated the effect of six lab-produced saliva substitutes based on carboxymethylcellulose (CMC) differing in octacalciumphosphate saturations (OCP-s) on mineralisation of bovine dentin in vitro.
  69. ncbi A pre-application drop containing carboxymethylcellulose can reduce multipurpose solution-induced corneal staining
    Jerry R Paugh
    Southern California College of Optometry, Fullerton, Fullerton, California 92831, USA
    Optom Vis Sci 84:65-71. 2007
    ..In vitro data suggest that carboxymethylcellulose (CMC) may neutralize polyhexanides...
  70. pmc Fewer intraperitoneal adhesions with use of hyaluronic acid-carboxymethylcellulose membrane: a randomized clinical trial
    Wietske W Vrijland
    Department of Surgery, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Ann Surg 235:193-9. 2002
    ..To assess the effectiveness of bioresorbable Seprafilm membrane in preventing abdominal adhesions in a prospective clinical randomized multicenter trial...
  71. ncbi The effect of commercially available saliva substitutes on predemineralized bovine dentin in vitro
    H Meyer-Lueckel
    Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Freie Universitaet, Berlin, Germany
    Oral Dis 8:192-8. 2002
    ..The objective of this study was to evaluate the effects of various saliva substitutes (Artisial; Glandosane; Oralube; Saliva medac; Oralbalance) on the lesion depth and the mineral content of predemineralized bovine dentin in vitro...
  72. ncbi Microbicidal properties of a silver-containing hydrofiber dressing against a variety of burn wound pathogens
    P G Bowler
    ConvaTec Global Development Centre, Deeside, United Kingdom
    J Burn Care Rehabil 25:192-6. 2004
    ..Based on our results, the silver-containing dressing is likely to provide a barrier to infection, in addition to providing proven fluid-handling benefits of the AQUACEL Hydrofiber dressing, in the management of partial-thickness burns...
  73. ncbi Comparison of the ionic silver-containing hydrofiber and paraffin gauze dressing on split-thickness skin graft donor sites
    Visnu Lohsiriwat
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Ann Plast Surg 62:421-2. 2009
    ..70, respectively (P = 0.027). There was no infection or seroma in both groups. In conclusion, ionic silver-containing Hydrofiber dressing can reduce STSG donor site pain and promote re-epithelization compared to paraffin gauze dressing...
  74. ncbi Viscous carboxymethylcellulose in the prevention of epidural scar formation
    T Kitano
    Department of Orthopaedic Surgery, University of Texas South Western Medical Center, Dallas, Texas
    Spine (Phila Pa 1976) 16:820-3. 1991
    ..One agent was carboxymethylcellulose and the other five agents represented various compositions of modified carboxymethylcellulose...
  75. ncbi Effects of hyaluronic acid-carboxymethylcellulose membrane on extraneural adhesion formation and peripheral nerve regeneration
    Gokhan Adanali
    Department of Plastic and Reconstructive Surgery, Ankara Numune Research and Training Hospital, Ankara, Turkey
    J Reconstr Microsurg 19:29-36. 2003
    ..In the present study, the effect of the membrane formed by a mixture of hyaluronic acid and carboxymethylcellulose (HA-CMC) on nerve regeneration and perineurial scar formation was investigated...
  76. ncbi Modelling the cost implications of using carboxymethylcellulose dressing compared with gauze in the management of surgical wounds healing by secondary intention in the US and UK
    Julian F Guest
    CATALYST Health Economics Consultants, Northwood, Middlesex, UK
    Curr Med Res Opin 21:281-90. 2005
    ..To estimate the costs of using carboxymethyl cellulose dressing (CMCD; Aquacel* Hydrofiber) compared to gauze in managing surgical wounds healing by secondary intention in the US and UK...
  77. ncbi Bone defect healing with an osteogenic protein-1 device combined with carboxymethylcellulose
    Stephen D Cook
    Department of Orthopaedic Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, SL 32, New Orleans, Louisiana 70112, USA
    J Biomed Mater Res B Appl Biomater 75:137-45. 2005
    ..The addition of carboxymethylcellulose (CMC) to the particulate collagen carrier (OPCMC device) to form the putty consistency was evaluated in ..
  78. ncbi Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anh
    S C Kunder
    Department of Microbiology and Immunology, Medical College of Pennsylvania, Philadelphia 19129
    Antiviral Res 21:233-45. 1993
    ..pICLC also effectively protected aged mice against lethal MCMV infection and effectively induced IFN. These results emphasize the potential for BRM treatment in immunocompromised hosts...
  79. doi Laparoscopic application of hyaluronate/carboxymethylcellulose slurry: an adhesion barrier in a slurry formulation goes where the available sheets cannot
    Bradford W Fenton
    Department of Obstetrics and Gynecology, Summa Health System, Akron, OH, USA
    Am J Obstet Gynecol 199:325.e1. 2008
  80. ncbi A novel instrument and technique for using Seprafilm hyaluronic acid/carboxymethylcellulose membrane during laparoscopic myomectomy
    Hiroyuki Takeuchi
    Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan
    J Laparoendosc Adv Surg Tech A 16:497-502. 2006
    ..Seprafilm can be used safely and efficiently during laparoscopic surgery...
  81. ncbi Paradoxical inflammatory reaction to Seprafilm: case report and review of the literature
    Marianne David
    Department of Surgery and the Department of Pathology, George Washington University, Washington, DC 20037, USA
    South Med J 98:1039-41. 2005
    ..The information provided by this and other atypical reports suggests that further studies aimed at identifying the incidence and pathophysiological mechanisms for such paradoxical reactions are needed...
  82. ncbi Antiadhesive effect of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose after endoscopic sinus surgery
    Jeong Hong Kim
    Department of Otorhinolaryngology, Brain Korea 21 Project for Medical Science, Seoul, South Korea
    Am J Rhinol 21:95-9. 2007
    We evaluated the clinical efficacy and safety of the mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HA-CMC) for prevention of adhesion after endoscopic sinus surgery.
  83. ncbi Prevention of adhesion formation after radical hysterectomy using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier: a cost-effectiveness analysis
    Robert E Bristow
    The Kelly Gynecologic Oncology Service, Department of Obstetrics and Gynecology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Gynecol Oncol 104:739-46. 2007
    ....
  84. ncbi Strategies for refinement of abdominal device implantation in mice: strain, carboxymethylcellulose, thermal support, and atipamezole
    Nancy A Johnston
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, USA
    J Am Assoc Lab Anim Sci 46:46-53. 2007
    ..associated with increased mortality (atipamezole) or were otherwise detrimental (the abdominal lubricant carboxymethylcellulose), whereas others had little or no effect on recovery (thermal support)...
  85. ncbi Effect of polymers used in saliva substitutes on demineralized bovine enamel and dentin
    Hendrik Meyer-Lueckel
    Department of Operative Dentistry and Periodontology, Medical University of Berlin, Charite, Germany
    Am J Dent 19:308-12. 2006
    To evaluate the effects of porcine mucin- and carboxymethylcellulose-based (CMC) solutions on the inhibition of demineralization of pre-demineralized bovine enamel and dentin in vitro...
  86. ncbi [Anaphylaxis after injection of corticosteroid preparations--carboxymethylcellulose as a hidden allergen]
    Roland Oppliger
    Unité d Allergologie, Service d allergologie et d immunologie clinique
    J Dtsch Dermatol Ges 2:928-30. 2004
    Two patients developed anaphylaxis after injection of a corticosteroid preparation containing carboxymethylcellulose (E466). In both cases skin tests yielded positive immediate type reactions to pure carboxymethylcellulose...
  87. ncbi Carboxymethylcellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healing
    Qian Garrett
    Institute for Eye Research, University of New South Wales, Sydney, NSW 2052, Australia
    Invest Ophthalmol Vis Sci 48:1559-67. 2007
    In this study, the ability of carboxymethylcellulose (CMC), used in artificial tear formulations, to interact with corneal-epithelial-cells (HCECs) and facilitate corneal epithelial wound healing was investigated.
  88. ncbi The efficacy of a hyaluronate-carboxymethylcellulose bioresorbable membrane that reduces postoperative adhesions is increased by the intra-operative co-administration of a neurokinin 1 receptor antagonist in a rat model
    Rizal Lim
    Department of Surgery, Boston University School of Medicine, Boston, MA, USA
    Surgery 148:991-9. 2010
    Bioresorbable membranes composed of hyaluronic acid and carboxymethylcellulose (HA/CMC) are the most effective method to prevent intra-abdominal adhesions; however, their efficacy may be limited to the site of application...
  89. ncbi Allergy to carboxymethylcellulose
    N Muroi
    Department of Pharmacology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Allergy 57:1212-3. 2002
  90. ncbi Compressed mini-tablets as a biphasic delivery system
    Carla M Lopes
    Departamento de Tecnologia Farmacêutica, Faculdade de Farmacia, Universidade do Porto, Rua Anibal Cunha 164, 4050 047 Porto, Portugal
    Int J Pharm 323:93-100. 2006
    ..Based on the release kinetic parameters calculated, it can be concluded that mini-tablets containing HPMC were particularly suitable approaching to zero-order (constant) release over 8h time periods...
  91. pmc Characterization of a functional soluble form of a Brassica napus membrane-anchored endo-1,4-beta-glucanase heterologously expressed in Pichia pastoris
    M Mølhøj
    Biotechnology Group and Center for Molecular Plant Physiology PlaCe, Danish Institute of Agricultural Sciences, Thorvaldsensvej 40, DK 1871 Frederiksberg C, Denmark
    Plant Physiol 127:674-84. 2001
    ..Size exclusion analysis of Delta(1-90)Cel16-hydrolyzed carboxymethylcellulose showed that Delta(1-90)Cel16 is a true endo-acting glucanase.
  92. ncbi Effective prevention of adhesions with hyaluronate
    Klaus Kramer
    Department of Surgery, University of Muenster, Germany
    Arch Surg 137:278-82. 2002
    ..Hyaluronate sodium in the form of a bioresorbant membrane reduces the development of intra-abdominal adhesions frequently found after implantation of synthetic mesh in the context of surgical hernia repair...
  93. ncbi Coating quality as a function of coating material properties: water-soluble cellulose derivatives as coating agents
    K Nienaltowska
    Food Technology and Engineering, Ghent University Coupure Links 653, BE 9000 Gent, Belgium, 2 Biosystems Engineering, Ghent University
    Commun Agric Appl Biol Sci 72:249-53. 2007
  94. ncbi Mechanical and degradation behavior of polymer-calcium sulfate composites
    K N Lewis
    Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506, USA
    J Mater Sci Mater Med 17:531-7. 2006
    ..The present study investigated the effect of viscous polymers, such as carboxymethylcellulose (CMC) and hyaluronan (HY), on the handling characteristics, mechanical properties, and degradation ..
  95. pmc Formulation of controlled-release baclofen matrix tablets: influence of some hydrophilic polymers on the release rate and in vitro evaluation
    Hamdy Abdelkader
    Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt
    AAPS PharmSciTech 8:E100. 2007
    ..levels of hydrophilic matrixing agents, including methylcellulose (MC), sodium alginate (Alg), and sodium carboxymethylcellulose (CMC), in an attempt to formulate controlled-release matrix tablets containing 25 mg baclofen...
  96. ncbi A new approach for studying correlations between the chemical structure and the rheological properties in carboxymethyl cellulose
    Jonas Enebro
    School of Chemical Science and Engineering, Fibre and Polymer Technology, Royal Institute of Technology KTH, Stockholm, Sweden
    Biomacromolecules 8:3253-7. 2007
    ..Furthermore, the CMC with the strongest attractive intermolecular interactions, according to rheometry, also contained the highest fraction of nonsubstituted cellulose segments...
  97. ncbi The effects of anti-adhesion materials in preventing postoperative adhesion in abdominal cavity (anti-adhesion materials for postoperative adhesions)
    Mustafa Sahin
    Department of General Surgery, Selcuk University Meram Medical Faculty, Konya, Turkey
    Inflammation 30:244-9. 2007
    ..The purpose of this study was to compare the effects of anti-adhesion materials in postoperative adhesions...
  98. ncbi Impact of compression pressure on tablet appearance
    Ryuhei Matsumoto
    Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co Ltd, Okubo 3, Tsukuba 300 2611, Ibaraki, Japan
    Int J Pharm 341:44-9. 2007
    ..Thus, the surface roughness seemed to govern gloss and color. The compression pressure seems to be one of the most important factors to control tablet appearance...
  99. ncbi Investigation of an artificial intelligence technology--Model trees. Novel applications for an immediate release tablet formulation database
    Q Shao
    Institute of Pharmaceutical Innovation, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Eur J Pharm Sci 31:137-44. 2007
    ..However, additional and valuable knowledge hidden in the formulation database was extracted from these equations. It is concluded that, as a transparent technology, model trees are useful tools to formulators...
  100. ncbi Comparison of neurofuzzy logic and decision trees in discovering knowledge from experimental data of an immediate release tablet formulation
    Q Shao
    Institute of Pharmaceutical Innovation, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Eur J Pharm Sci 31:129-36. 2007
    ..formulation ingredients (silica aerogel, magnesium stearate, microcrystalline cellulose and sodium carboxymethylcellulose) and process variables (dwell time and compression force) to tablet properties (tensile strength, ..
  101. ncbi Modulation of a pulsatile release drug delivery system using different swellable/rupturable materials
    Hoda A El-Maradny
    Department of Industrial Pharmacy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
    Drug Deliv 14:539-46. 2007
    ..Increasing the level of ethylcellulose coating retarded the diffusion of the release medium to the swelling layer and the rupture of the coat, thus prolonging the lag time...

Research Grants26

  1. Characterization of Tear Dynamics
    Jianhua Wang; Fiscal Year: 2007
    ..g. dry eye). [unreadable] [unreadable]..
  2. Novel Biomaterials as Sealants for Applications in Annulus Fibrosus Repair
    Clare Canal Guterl; Fiscal Year: 2012
    ..The two gels proposed are a genipin cross- linked fibrin gel (fib-gen) and carboxymethylcellulose hydrogel (CMC)...
  3. Hiltonol provides potent neuroprotection from ischemic brain injury in stroke.
    Mary P Stenzel-Poore; Fiscal Year: 2013
    ..Phase I/II clinical trials that consists of polyinosinic-polycytidylic acid stabilized by oly-L-lysine and carboxymethylcellulose (poly-ICLC)...
  4. NIAID Clinical Trial Planning Grant
    Nina Bhardwaj; Fiscal Year: 2011
    ..ex vivo and administered with a potent adjuvant, Poly-ICLC, (polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose;Hiltonol(r), Oncovir), will stimulate innate and adaptive immune responses which will in turn reduce ..
  5. Raising Literacy and Capacity for Incontinence and Skin Care in Dementia
    Donna Bliss; Fiscal Year: 2009
    ....
  6. Impact of Fiber Fermentation on Fecal Incontinence
    Donna Bliss; Fiscal Year: 2007
    ..Differences among the measures of the groups after supplementation will be compared after controlling for baseline values of these measures using ANCOVA. ..
  7. Vaccination With Peptide-loaded alphaDC1s For Malignant Gliomas
    Hideho Okada; Fiscal Year: 2008
    ..Information from this pilot study will establish a basis to design subsequent trials with patient populations in which more significant clinical benefit might be realized. ..
  8. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
  9. Primate Models of Autism
    MELISSA DAWN contact BAUMAN; Fiscal Year: 2010
    ....
  10. Poly-ICLC Prophylaxis Treatment of Ebola Virus Infection
    Andres Salazar; Fiscal Year: 2005
    ..C) To develop GMP manufacturing methods for Poly-ICLC, in compliance with specific FDA guidance. ..
  11. Chimeric Yellow Fever/West Nile Virus:Candidate Vaccine
    Rafi Ahmed; Fiscal Year: 2003
    ..abstract_text> ..
  12. Pox Virus Immunology and Vaccine Development
    Rafi Ahmed; Fiscal Year: 2007
    ..abstract_text> ..
  13. NABTT-Consortium Therapeutic Studies of CNS Malignancies
    Stuart Grossman; Fiscal Year: 2008
    ..abstract_text> ..
  14. Devices for Treating Inflammatory Bone Loss in an Oral Environment
    David A Puleo; Fiscal Year: 2010
    ..This project will develop multifunctional, unitary, controlled release devices that halt the detrimental processes and stimulate localized tissue repair in sites compromised by bacteria. ..
  15. Mechanisms of influenza NA drug resistance
    Jennifer L McKimm Breschkin; Fiscal Year: 2010
    ....
  16. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  17. FASEB Summer Conference on Microbial Polysaccharides
    Arthur Tzianabos; Fiscal Year: 2004
    ..This meeting will provide a unique environment for scientific exchange between a diverse group of investigators in the area of microbial polysaccharides. ..
  18. Molecular Imprinting to Control Cell Responses
    David Puleo; Fiscal Year: 2004
    ..By promoting desired cell activities, biospecific biomaterials can control initial events at the cell-biomaterial interface. ..
  19. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
  20. Surgical Adhesions: Role of T cells in Pathogenesis
    Arthur Tzianabos; Fiscal Year: 2005
    ..abstract_text> ..
  21. ANGIOTENSIN ANALOGS TO TREAT WOUND HEALING
    Kathleen Rodgers; Fiscal Year: 2005
    ..In this phase II SBIR, these compounds will undergo extensive preclinical testing to determine whether they should be further developed as a second generation of wound healing drugs. ..
  22. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..aureus infections. This information may reveal new strategies for the prevention or treatment of S. aureus infections through immunomodulation of the host response to this organism. ..
  23. Biomaterials with Rationally Immobilized Growth Factors
    David Puleo; Fiscal Year: 2006
    ..The findings of these studies will impact the development of bone-contacting biomaterials having the ability to induce desired interracial responses. ..
  24. TEACHING BIOLOGY THROUGH IMMUNOLOGY FELLOWSHIPS
    Arthur Tzianabos; Fiscal Year: 2007
    ..Thus, we will also survey each teacher and school district previously in the program in order to determine the effect of the program on science education and student career choices. [unreadable] [unreadable]..
  25. Novel keratinocyte-based therapy for chronic wounds
    Riley Rees; Fiscal Year: 2002
    ..abstract_text> ..