biopolymers

Summary

Summary: Polymers synthesized by living organisms. They play a role in the formation of macromolecular structures and are synthesized via the covalent linkage of biological molecules, especially AMINO ACIDS; NUCLEOTIDES; and CARBOHYDRATES.

Top Publications

  1. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
  2. pmc Novel eukaryotic enzymes modifying cell-surface biopolymers
    Vivek Anantharaman
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Biol Direct 5:1. 2010
  3. pmc Robust pore size analysis of filamentous networks from three-dimensional confocal microscopy
    Walter Mickel
    Institut fur Theoretische Physik, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Biophys J 95:6072-80. 2008
  4. pmc ATP-binding cassette transporter G26 is required for male fertility and pollen exine formation in Arabidopsis
    Teagen D Quilichini
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
    Plant Physiol 154:678-90. 2010
  5. ncbi Extraction of extracellular polymeric substances (EPS) of sludges
    Hong Liu
    Department of Civil Engineering, Centre for Environmental Engineering Research, The University of Hong Kong, Pokfulam Road, Hong Kong
    J Biotechnol 95:249-56. 2002
  6. ncbi Characterisation of aquatic humic and non-humic matter with size-exclusion chromatography--organic carbon detection--organic nitrogen detection (LC-OCD-OND)
    Stefan A Huber
    DOC LABOR Dr Huber, Karlsruhe, Germany
    Water Res 45:879-85. 2011
  7. pmc Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state
    Marina Caldara
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Biol 22:2325-30. 2012
  8. ncbi Layer-by-layer assembly of chitosan and recombinant biopolymers into biomimetic coatings with multiple stimuli-responsive properties
    Rui R Costa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Avepark, Zona Industrial da Gandra, São Cláudio do Barco, 4806 909 Caldas das Taipas, Guimaraes, Portugal
    Small 7:2640-9. 2011
  9. pmc The basic reproductive ratio of life
    Michael L Manapat
    Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 263:317-27. 2010
  10. ncbi Extracellular polymeric substances (EPS) of microbial aggregates in biological wastewater treatment systems: a review
    Guo Ping Sheng
    School of Chemistry, University of Science and Technology of China, Hefei, China
    Biotechnol Adv 28:882-94. 2010

Detail Information

Publications364 found, 100 shown here

  1. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity...
  2. pmc Novel eukaryotic enzymes modifying cell-surface biopolymers
    Vivek Anantharaman
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Biol Direct 5:1. 2010
    ..external tests, capsules, cell walls and waxes contain highly modified proteins, glycans and other composite biopolymers. Using comparative genomics and sequence profile analysis we identify several novel enzymes that could be ..
  3. pmc Robust pore size analysis of filamentous networks from three-dimensional confocal microscopy
    Walter Mickel
    Institut fur Theoretische Physik, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    Biophys J 95:6072-80. 2008
    ..We also provide empirical support for a recent claim that the percolation threshold of a fiber network is close to the fiber diameter for which the Euler index of the networks becomes zero...
  4. pmc ATP-binding cassette transporter G26 is required for male fertility and pollen exine formation in Arabidopsis
    Teagen D Quilichini
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
    Plant Physiol 154:678-90. 2010
    ....
  5. ncbi Extraction of extracellular polymeric substances (EPS) of sludges
    Hong Liu
    Department of Civil Engineering, Centre for Environmental Engineering Research, The University of Hong Kong, Pokfulam Road, Hong Kong
    J Biotechnol 95:249-56. 2002
    ..Optimization of extraction procedures and/or development of a more effective extraction method are warranted...
  6. ncbi Characterisation of aquatic humic and non-humic matter with size-exclusion chromatography--organic carbon detection--organic nitrogen detection (LC-OCD-OND)
    Stefan A Huber
    DOC LABOR Dr Huber, Karlsruhe, Germany
    Water Res 45:879-85. 2011
    ..This approach is described with recent improvements in fraction assignation (humic substances, biopolymers, building blocks, low molecular weight organic acids and neutrals, hydrophobic organic carbon), the coupling of ..
  7. pmc Mucin biopolymers prevent bacterial aggregation by retaining cells in the free-swimming state
    Marina Caldara
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Biol 22:2325-30. 2012
    ..Using defined in vitro assays, we found that mucin biopolymers, the main functional constituents of mucus, promote the motility of planktonic bacteria and prevent their ..
  8. ncbi Layer-by-layer assembly of chitosan and recombinant biopolymers into biomimetic coatings with multiple stimuli-responsive properties
    Rui R Costa
    3B s Research Group Biomaterials, Biodegradables and Biomimetics, University of Minho, Avepark, Zona Industrial da Gandra, São Cláudio do Barco, 4806 909 Caldas das Taipas, Guimaraes, Portugal
    Small 7:2640-9. 2011
    ..The results suggest that such films could be used in the future as smart biomimetic coatings of biomaterials for different biomedical applications, including those in tissue engineering or in controlled delivery systems...
  9. pmc The basic reproductive ratio of life
    Michael L Manapat
    Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    J Theor Biol 263:317-27. 2010
    ..Our work on the evolution of replication has interesting parallels to infection dynamics. Life (replication) can be seen as an infection of prelife...
  10. ncbi Extracellular polymeric substances (EPS) of microbial aggregates in biological wastewater treatment systems: a review
    Guo Ping Sheng
    School of Chemistry, University of Science and Technology of China, Hefei, China
    Biotechnol Adv 28:882-94. 2010
    ..However, as EPS are very complex, the knowledge regarding EPS is far from complete and much work is still required to fully understand their precise roles in the biological treatment process...
  11. ncbi Spectroscopic study of extracellular polymeric substances from Bacillus subtilis: aqueous chemistry and adsorption effects
    Anselm Omoike
    Department of Soil, Water and Environmental Science, University of Arizona, Tucson, Arizona 85721 0038, USA
    Biomacromolecules 5:1219-30. 2004
    ..Goethite-EPS spectra show emergent vibrations consistent with P-O-Fe bonding, which suggests a role of phosphodiester groups in the adsorption reaction...
  12. ncbi An ABCG/WBC-type ABC transporter is essential for transport of sporopollenin precursors for exine formation in developing pollen
    Hyunju Choi
    POSTECH University of Zurich Global Research Laboratory, Division of Molecular Life Sciences, POSTECH, Pohang 790 784, Korea
    Plant J 65:181-93. 2011
    ..Taken together, these results suggest that ABCG26 plays a crucial role in the transfer of sporopollenin lipid precursors from tapetal cells to anther locules, facilitating exine formation on the pollen surface...
  13. pmc Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization
    Ivan M Blasutig
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 1084 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Mol Cell Biol 28:2035-46. 2008
    ..Together, these data identify pYDXV/Nck signaling as a potent and portable mechanism for physiological and pathological actin regulation...
  14. ncbi Origin of self-replicating biopolymers: autocatalytic feedback can jump-start the RNA world
    Meng Wu
    Department of Physics and Astronomy, Origins Institute, McMaster University, Hamilton, ON, L8S 4M1, Canada
    J Mol Evol 69:541-54. 2009
    Life is based on biopolymers that have the ability to replicate themselves. Here we consider how a self-replicating RNA system may have originated...
  15. pmc Cytochrome P450 family member CYP704B2 catalyzes the {omega}-hydroxylation of fatty acids and is required for anther cutin biosynthesis and pollen exine formation in rice
    Hui Li
    School of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai 200240, China
    Plant Cell 22:173-90. 2010
    ..Our results provide insights into the biosynthesis of the two biopolymers sporopollenin and cutin...
  16. ncbi Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin
    M R Bubb
    Laboratory of Cell Biology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:14869-71. 1994
    ..These results imply that jasplakinolide may exert its cytotoxic effect in vivo by inducing actin polymerization and/or stabilizing pre-existing actin filaments...
  17. ncbi Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease
    Omar M A El-Agnaf
    Department of Biochemistry, Faculty of Medicine and Health Science, United Arab Emirates University, Al Ain P O Box 17666, United Arab Emirates
    FASEB J 20:419-25. 2006
    ..597-0.948). These observations offer new opportunities for developing diagnostic tests for PD and related diseases and for testing therapeutic agents aimed at preventing or reversing the aggregation of alpha-syn...
  18. pmc Import of biopolymers into Escherichia coli: nucleotide sequences of the exbB and exbD genes are homologous to those of the tolQ and tolR genes, respectively
    K Eick-Helmerich
    Mikrobiologie II, Universitat Tubingen, Federal Republic of Germany
    J Bacteriol 171:5117-26. 1989
    ..It is concluded that the exb- and tol-dependent systems originate from a common uptake system for biopolymers.
  19. ncbi Fibrillin-rich microfibrils: elastic biopolymers of the extracellular matrix
    C M Kielty
    School of Medicine, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Muscle Res Cell Motil 23:581-96. 2002
    ..This information will enhance our understanding of the elastic mechanism of these unique extracellular matrix polymers, and may lead to new microfibril-based strategies for repairing elastic tissues in ageing and disease...
  20. ncbi Exploitation of olive oil mill wastewater for combined biohydrogen and biopolymers production
    I Ntaikou
    Department of Chemical Engineering, University of Patras, Karatheodori 1 st, 26500 Patras, Greece
    Bioresour Technol 100:3724-30. 2009
    The present study aimed to the investigation of the feasibility of the combined biohydrogen and biopolymers production from OMW (Olive oil Mill Wastewater), using a two stage system...
  21. pmc Ensemble-based convergence analysis of biomolecular trajectories
    Edward Lyman
    Department of Computational Biology, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Biophys J 91:164-72. 2006
    ..Our initial study on met-enkephalin strongly suggests that even fairly long trajectories (approximately 50 ns) may not be converged for this small--but highly flexible--system...
  22. ncbi Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse
    Timothy S Gomez
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nat Immunol 6:261-70. 2005
    ..These data identify a functionally important interaction between Dyn2 and Vav1 that regulates actin reorganization and multiple signaling pathways in T lymphocytes...
  23. ncbi The role of the biofilm matrix in structural development
    N G Cogan
    Mathematics Department, Tulane University, New Orleans, LA 70118, USA
    Math Med Biol 21:147-66. 2004
    ....
  24. ncbi Genetic regulation of sporopollenin synthesis and pollen exine development
    Tohru Ariizumi
    University of Tsukuba, Gene Research Center, Tsukuba, Ibaraki 305 8572, Japan
    Annu Rev Plant Biol 62:437-60. 2011
    ....
  25. ncbi Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds
    Biji Balakrishnan
    Polymer Chemistry Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Satelmond Palace Campus, Poojapura, Trivandrum, Kerala 695012, India
    Biomaterials 26:3941-51. 2005
    ..The potential of the system as an injectable drug delivery vehicle and as a tissue-engineering scaffold is demonstrated by using primaquine as a model drug and by encapsulation of hepatocytes inside the gel matrix, respectively...
  26. ncbi Yeast [PSI+] prion aggregates are formed by small Sup35 polymers fragmented by Hsp104
    Dmitry S Kryndushkin
    Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya Street 15A, 121552 Moscow, Russia
    J Biol Chem 278:49636-43. 2003
    ..Blocked expression of Hsp104 chaperone causes gradual increase in the size of prion polymers, while inactivation of Hsp104 by guanidine HCl completely stops their fragmentation, which shows indispensability of Hsp104 for this process...
  27. ncbi Helix-like biopolymers can act as dampers of force for bacteria in flows
    Johan Zakrisson
    Department of Physics, Umea University, 901 87 Umea, Sweden
    Eur Biophys J 41:551-60. 2012
    b>Biopolymers are vital structures for many living organisms; for a variety of bacteria, adhesion polymers play a crucial role for the initiation of colonization...
  28. pmc Mucin biopolymers as broad-spectrum antiviral agents
    Oliver Lieleg
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Biomacromolecules 13:1724-32. 2012
    ..Our findings suggest that purified mucins may be used as a broad-range antiviral supplement to personal hygiene products, baby formula or lubricants to support our immune system...
  29. ncbi Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response
    Catarina P Reis
    Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000 295 Coimbra, Portugal
    J Pharm Sci 97:5290-305. 2008
    ..This formulation demonstrates beneficial effects on diabetic symptoms and will be of interest in the treatment of diabetes with oral insulin...
  30. ncbi Interactions between alginate and chitosan biopolymers characterized using FTIR and XPS
    Gwen Lawrie
    School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Biomacromolecules 8:2533-41. 2007
    ..However, in combination with XPS (survey and narrow N 1s scans) and solution stability evaluation, a more complete description of the structure can be obtained. This conclusion challenges the assignment of FTIR spectra in the literature...
  31. ncbi Poly(ethylene glycol)-mediated molar mass control of short-chain- and medium-chain-length poly(hydroxyalkanoates) from Pseudomonas oleovorans
    R D Ashby
    United States Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 E Mermaid Lane, Wyndmoor, PA 19038 USA
    Appl Microbiol Biotechnol 60:154-9. 2002
    ..In contrast, the PHB produced by B-14682 showed a 35% reduction in molar mass in the presence of PEG-400...
  32. ncbi Preparation and characterization of a thermostable and biodegradable biopolymers using natural cross-linker
    Tapas Mitra
    Microbiology Division, Central Leather Research Institute, CSIR, New Delhi, Adyar, Chennai 20, Tamil Nadu, India
    Int J Biol Macromol 48:276-85. 2011
    ..A supplementary file on efficacy of AACC as a wound dressing material is demonstrated in detail with animal model studies...
  33. pmc Structure of bacterial extracellular polymeric substances at different pH values as determined by SAXS
    Iztok Dogsa
    Laboratory for Biophysics, Jozef Stefan Institute, Ljubljana, Slovenia
    Biophys J 89:2711-20. 2005
    ..7. The average distance between the polysaccharide chains at pH 0.7 was 2.3 nm, which indicates a compact EPS structure. Swelling was found to be at a maximum around pH = 8.8, where the average distance between the chains was 4.8 nm...
  34. ncbi Cofilin promotes actin polymerization and defines the direction of cell motility
    Mousumi Ghosh
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Science 304:743-6. 2004
    ..We propose a role for cofilin that is distinct from its role as an actin-depolymerizing factor...
  35. pmc Polymalic acid-based nanobiopolymer provides efficient systemic breast cancer treatment by inhibiting both HER2/neu receptor synthesis and activity
    Satoshi Inoue
    Department of Neurosurgery and Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Cancer Res 71:1454-64. 2011
    ..Our findings offer a preclinical proof of concept for use of the PMLA nanoplatform for combination cancer therapy...
  36. ncbi Electrospinning of collagen/biopolymers for regenerative medicine and cardiovascular tissue engineering
    Scott A Sell
    Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 23284 3067, USA
    Adv Drug Deliv Rev 61:1007-19. 2009
    ..towards the creation of bioresorbable vascular grafts composed of electrospun nanofibers of collagen and other biopolymers. These bioresorbable grafts have compositions that allow for the in situ remodeling of the structure, with the ..
  37. pmc Analysis of TETRAKETIDE α-PYRONE REDUCTASE function in Arabidopsis thaliana reveals a previously unknown, but conserved, biochemical pathway in sporopollenin monomer biosynthesis
    Etienne Grienenberger
    Institut de Biologie Moleculaire des Plantes, Unité Propre de Recherche 2357 du Centre National de la Recherche Scientifique, Universite de Strasbourg, 67084 Strasbourg Cedex, France
    Plant Cell 22:4067-83. 2010
    ..TKPR activities, together with those of ACOS5 and PKSA/B, identify a conserved biosynthetic pathway leading to hydroxylated α-pyrone compounds that were previously unknown to be sporopollenin precursors...
  38. ncbi The solution structure of the bovine S100B protein dimer in the calcium-free state
    P M Kilby
    Department of Biochemistry and Biological NMR Centre, Adrian Building, University of Leicester, Leicester, LE1 7RH, UK
    Structure 4:1041-52. 1996
    ..Identification of a growing class of S100 proteins and the likely neurochemical importance of S100B make the determination of the structure of S100B of interest...
  39. ncbi Marine biopolymer self-assembly: implications for carbon cycling in the ocean
    Pedro Verdugo
    Department of Bioengineering, University of Washington, Friday Harbor Laboratories, Box 351812, Friday Harbor, WA 98250, USA
    Faraday Discuss 139:393-8; discussion 399-417, 419-20. 2008
    Dissolved organic matter is the largest reservoir of reduced carbon in the ocean and is primarily composed of small biopolymers. It is a critical substrate for the microbial community and plays a pivotal role in global carbon cycling.
  40. ncbi Lactose hydrolysis by beta-galactosidase covalently immobilized to thermally stable biopolymers
    Magdy M M Elnashar
    Polymers Department, Centre of Scientific Excellence Advanced Materials and Nanotechnology Laboratory, National Research Center, El Behooth St Dokki, Cairo, Egypt
    Appl Biochem Biotechnol 159:426-37. 2009
    ..The new carrier could be suitable for immobilization of other industrial enzymes...
  41. ncbi Biopolymeric delivery matrices for angiogenic growth factors
    Andreas H Zisch
    Institute for Biomedical Engineering and Department of Materials Science, Swiss Federal Institute of Technology Zurich ETHZ, Moussonstrasse 18, 8044 Zurich, Switzerland
    Cardiovasc Pathol 12:295-310. 2003
    ..Another promising venue to improve angiogenic performance is presented by biomaterials that allow sequential delivery of growth factors with complementary roles in blood vessel initiation and stabilization...
  42. ncbi Designed biomaterials to mimic the mechanical properties of muscles
    Shanshan Lv
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
    Nature 465:69-73. 2010
    ..We anticipate that these biomaterials will find applications in tissue engineering as scaffold and matrix for artificial muscles...
  43. ncbi Synthesis of biopolymers using genetic code reprogramming
    Atsushi Ohta
    Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 113 8656 Tokyo, Japan
    Curr Opin Chem Biol 12:159-67. 2008
    ....
  44. ncbi Structure and function of ESCRT-III
    Suman Lata
    Unit for Virus Host Cell Interaction, UMR 5233 UJF EMBL CNRS, 6 rue Jules Horowitz 38042 Grenoble Cedex 9, France
    Biochem Soc Trans 37:156-60. 2009
    ..Progress towards the understanding of the structures and function of ESCRT-III, its activation, its regulation by accessory factors and its role in abscission of membrane enveloped structures in concert with VPS4 are discussed...
  45. pmc Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid)
    Manabu Fujita
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Control Release 122:356-63. 2007
    ..The results suggest improved efficacy for tandem configuration of antibodies than for single configurations carried by a drug delivery vehicle...
  46. ncbi Physical properties of biopolymers assessed by optical tweezers: analysis of folding and refolding of bacterial pili
    Magnus Andersson
    Department of Physics Umeå University, SE 901 87 Umea, Sweden
    Chemphyschem 9:221-35. 2008
    ..The information retrieved is also compared with that obtained by atomic force microscopy...
  47. ncbi Production of a biopolymer flocculant from Bacillus licheniformis and its flocculation properties
    I L Shih
    Department of Environmental Engineering, Da Yeh University, Taiwan, ROC
    Bioresour Technol 78:267-72. 2001
    ..The high productivity and versatile applications of PGA make its development as a new biodegradable, harmless, biopolymer flocculant economical and advantageous...
  48. ncbi Nonlinear elasticity in biological gels
    Cornelis Storm
    Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA
    Nature 435:191-4. 2005
    ..This theory shows that systems of filamentous proteins arranged in an open crosslinked mesh invariably stiffen at low strains without requiring a specific architecture or multiple elements with different intrinsic stiffness...
  49. pmc Cell therapy attenuates cardiac dysfunction post myocardial infarction: effect of timing, routes of injection and a fibrin scaffold
    Juliana S Nakamuta
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 4:e6005. 2009
    ....
  50. pmc Self-organization of actin filament orientation in the dendritic-nucleation/array-treadmilling model
    Thomas E Schaus
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 104:7086-91. 2007
    ..A +70/0/-70 degree pattern was formed with flexible filaments approximately 100 nm or longer and with velocities < approximately 20% of free polymerization rates...
  51. pmc The EPS matrix: the "house of biofilm cells"
    Hans Curt Flemming
    Biofilm Centre, University of Duisburg Essen, Geibelstrasse 41, D 47057 Duisburg, Germany
    J Bacteriol 189:7945-7. 2007
  52. pmc Polyester synthases: natural catalysts for plastics
    Bernd H A Rehm
    Institut für Molekulare Mikrobiologie und Biotechnologie der Westfälischen Wilhelms Universität Münster, Corrensstrasse 3, 48149 Munster, Germany
    Biochem J 376:15-33. 2003
    ..This review provides a survey of the known biochemical features of these unique enzymes and their proposed catalytic mechanism...
  53. ncbi Physics in cell biology: on the physics of biopolymers and molecular motors
    Erwin Frey
    Hahn Meitner Institut Abteilung Theorie Glienicker Strasse 100, 14109 Berlin, Germany
    Chemphyschem 3:270-5. 2002
    ..The goal of this article is to highlight some examples where physics can contribute to questions in cell biology. One might hope that through interdisciplinary research one can get closer to answering Schrödinger's fundamental question...
  54. ncbi FtsZ rings and helices: physical mechanisms for the dynamic alignment of biopolymers in rod-shaped bacteria
    Elisabeth Fischer-Friedrich
    Department of Chemical Physics, Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    Phys Biol 9:016009. 2012
    ..This effect could provide an explanation to the long standing puzzle of transiently observed oscillating FtsZ helices in Escherichia coli cells prior to cell division...
  55. ncbi Fate of biopolymers during rapeseed meal and wheat bran composting as studied by two-dimensional correlation spectroscopy in combination with multiple fluorescence labeling techniques
    Li Ping Wang
    Jiangsu Key Lab for Organic Solid Waste Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, PR China
    Bioresour Technol 105:88-94. 2012
    ..FTIR) correlation spectroscopy and multiple fluorescent labeling, it was possible to study the degradation of biopolymers during rapeseed meal and wheat bran composting...
  56. ncbi Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin-like growth factor binding protein 4 with elastin-like polypeptides
    Ayaka Minato
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, B 57, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    Biomaterials 33:515-23. 2012
    ..These findings suggest that substrate immobilization of soluble factors is a useful technique for differentiation of ESCs in regenerative medicine and tissue engineering...
  57. ncbi Boletus edulis biologically active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells
    Marta Kinga Lemieszek
    Department of Medical Biology, Institute of Agricultural Medicine, Jaczewskiego 2, 20 090 Lublin, Poland
    Food Funct 4:575-85. 2013
    ..Anticancer properties are mainly attributed to biopolymers including mainly polysaccharides, polysaccharopeptides, polysaccharide proteins, glycoproteins and proteins...
  58. ncbi Langmuir-Blodgett films of biopolymers: a method to obtain protein multilayers
    J Sánchez-Gonzalez
    Materials Science and Metallurgical Engineering, Department of Electronics and Electromechanics Engineering, School of Industrial Engineering, University of Extremadura, 06071 Badajoz, Spain
    J Colloid Interface Sci 267:286-93. 2003
    ..Our methodology can be applied to other biomacromolecules to find the best conditions to form LB films from isotherm measurements...
  59. ncbi High-resolution NMR field-cycling device for full-range relaxation and structural studies of biopolymers on a shared commercial instrument
    Alfred G Redfield
    Biochemistry Department, Brandeis University, Mail stop 009, Waltham, MA 02154, USA
    J Biomol NMR 52:159-77. 2012
    ..36 s. Commercial probes are used and sensitivity is that of the host spectrometer reduced only by relaxation during travel. A key element is development of a linkage that prevents vibration of the linear motor from reaching the probe...
  60. ncbi Materials science. Mammalian cells spin a spidery new yarn
    Robert F Service
    Science 295:419-21. 2002
  61. ncbi "Sponge-like" dressings based on biopolymers for the delivery of platelet lysate to skin chronic wounds
    S Rossi
    Department of Drug Sciences, University of Pavia, Pavia, Italy
    Int J Pharm 440:207-15. 2013
    ..The PDGF AB assay confirmed the results obtained from cell proliferation test...
  62. ncbi Interplay of non-Markov and internal friction effects in the barrier crossing kinetics of biopolymers: insights from an analytically solvable model
    Dmitrii E Makarov
    Department of Chemistry and Biochemistry and Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, Texas 78712, USA
    J Chem Phys 138:014102. 2013
    ..Faster transitions (relative to the polymer reconfiguration time scale) involve fewer monomers and, correspondingly, lower friction forces, because the polymer chain does not have enough time to reconfigure in response to the transition...
  63. ncbi Chemical characteristics and immuno-stimulating properties of biopolymers extracted from Acanthopanax sessiliflorus
    Sang Chul Jeong
    Department of Biotechnology, Daegu University, Gyungsan, Gyungbuk 712 714, Korea
    J Biochem Mol Biol 39:84-90. 2006
    During our search for macrophage stimulating compounds from medicinal plants, we isolated biopolymers from Acanthopanax sessiliflorus...
  64. ncbi Assessment of respiration activity and ecotoxicity of composts containing biopolymers
    Michał Kopeć
    Department of Agricultural and Environmental Chemistry, University of Agriculture in Krakow, Al Mickiewicza 21, 31 120 Krakow, Poland
    Ecotoxicol Environ Saf 89:137-42. 2013
    ..In composts containing biopolymers the following were observed: an increase in germination inhibition--2.5 times, roots growth inhibition--1...
  65. ncbi Mineral surface directed membrane assembly
    Martin M Hanczyc
    Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA
    Orig Life Evol Biosph 37:67-82. 2007
    ..Similar interactions between amphiphiles and minerals on early Earth may have resulted in the encapsulation of a diverse array of mineral particulates with catalytic properties...
  66. ncbi Vibrational spectroscopy of biopolymers under mechanical stress: processing cellulose spectra using bandshift difference integrals
    Adriana Šturcová
    WestCHEM, Glasgow University, Glasgow G12 8QQ, Scotland, United Kingdom
    Biomacromolecules 7:2688-91. 2006
    ..The possibility of constructing spectral plots of bandshift has the potential to clarify the interpretation of overlapped, shifting bands in the vibrational spectra of polymers under tension...
  67. pmc Xenobiology: a new form of life as the ultimate biosafety tool
    Markus Schmidt
    Organisation for International Dialogue and Conflict Management, Kaiserstr 50 6, 1070 Vienna, Austria
    Bioessays 32:322-31. 2010
    ....
  68. ncbi Natural biopolymers: novel templates for the synthesis of nanostructures
    Sonal Padalkar
    School of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    Langmuir 26:8497-502. 2010
    ..to be used as templates for the synthesis of functional nanomaterials, but the properties of widely available biopolymers, such as cellulose, have been much less exploited for this purpose...
  69. ncbi Single-molecule speckle analysis of actin filament turnover in lamellipodia
    Naoki Watanabe
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 295:1083-6. 2002
    ..Most of the actin filaments in the lamellipodium were generated by polymerization away from the tip...
  70. ncbi The structure and biological features of fibrinogen and fibrin
    M W Mosesson
    Blood Research Institute, Blood Center of Southeastern Wisconsin, P O Box 2178, Milwaukee, Wisconsin 53201, USA
    Ann N Y Acad Sci 936:11-30. 2001
    ....
  71. ncbi Sequential production of two biopolymers-levan and poly-ε-lysine by microbial fermentation
    Ing Lung Shih
    Department of Environmental Engineering, Da Yeh University, Changhua, Taiwan
    Bioresour Technol 102:3966-9. 2011
    Sequential fermentation for the production of two invaluable biopolymers, levan and poly-ε-lysine (ε-PL), has been successfully developed...
  72. ncbi Importance of structural makeup of biopolymers for organic contaminant sorption
    Xilong Wang
    Department of Plant, Soil, and Insect Sciences, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Environ Sci Technol 41:3559-65. 2007
    ..of pyrene, phenanthrene, naphthalene, and 1-naphthol by original (lignin, chitin, and cellulose) and coated biopolymers was examined...
  73. ncbi Plasma-assisted surface modification of organic biopolymers to prevent bacterial attachment
    Kateryna Bazaka
    Electronic Materials Research Laboratory, School of Engineering and Physical Sciences, James Cook University, Townsville, Queensland, Australia
    Acta Biomater 7:2015-28. 2011
    ..Functional organic plasma polymerised coatings are also discussed for their potential as biosensitive interfaces, connecting inorganic/metallic electronic devices with their physiological environments...
  74. ncbi Biopolymers: shape memory in spider draglines
    Olivier Emile
    Laboratoire de Physique des Lasers, UMR CNRS 6627, Universite de Rennes 1, 35042 Rennes, France
    Nature 440:621. 2006
    ....
  75. ncbi High-resolution 14N-edited 1H-13C correlation NMR experiment to study biological solids
    Jean Paul Amoureux
    Unité de Catalyse et Chimie du Solide, UMR CNRS 8181, Universite de Lille 1, 59652 Villeneuve d Ascq cedex, France
    J Magn Reson 194:317-20. 2008
    ..The experiment is demonstrated on a (13)C enriched l-histidine. HCl x H(2)O powder sample...
  76. pmc Universal sequence replication, reversible polymerization and early functional biopolymers: a model for the initiation of prebiotic sequence evolution
    Sara Imari Walker
    NSF NASA Center for Chemical Evolution, Georgia Institute of Technology, Atlanta, Georgia, United States of America
    PLoS ONE 7:e34166. 2012
    ....
  77. ncbi An algorithm for extracting the network geometry of three-dimensional collagen gels
    Andrew M Stein
    Institute for Mathematics and Its Applications, University of Minnesota, Minneapolis, MN 55403, USA
    J Microsc 232:463-75. 2008
    ....
  78. ncbi The amino-terminal heptad repeats of the coiled-coil neck domain of pulmonary surfactant protein d are necessary for the assembly of trimeric subunits and dodecamers
    P Zhang
    Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Biol Chem 276:19862-70. 2001
    ..These studies provide strong evidence that the amino-terminal heptad repeats of the neck domain are necessary for the intracellular, trimeric association of SP-D monomers and for the assembly and secretion of functional dodecamers...
  79. ncbi Effect of biopolymers on structure and ice recrystallization in dynamically frozen ice cream model systems
    A Regand
    Department of Food Science, University of Guelph, Guelph, ON, NIG 2W1, Canada
    J Dairy Sci 85:2722-32. 2002
    ..Thermodynamic incompatibility between biopolymers was observed to promote localized high concentrations of milk proteins located at the ice crystal interface, ..
  80. ncbi Effect of instrument tuning on the detectabilityof biopolymers in electrospray ionization mass spectrometry
    Herbert Oberacher
    Instrumental Analysis and Bioanalysis, Saarland University, 66123 Saarbrucken, Germany
    J Mass Spectrom 38:108-16. 2003
    ....
  81. ncbi Hydrophobic hydration is an important source of elasticity in elastin-based biopolymers
    B Li
    Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195-7610, USA
    J Am Chem Soc 123:11991-8. 2001
    ..On the whole, our simulations support the hydrophobic mechanism of elasticity and provide a framework for description of the molecular basis of this phenomenon...
  82. ncbi Characterization and singlet oxygen quenching capacity of spray-dried microcapsules of edible biopolymers containing antioxidant molecules
    Adelia F Faria
    Department of Food Science, Faculty of Food Engineering, University of Campinas UNICAMP, Rua Monteiro Lobato 80, P O Box 6121, CEP 13083 862, Campinas, Brazil
    J Agric Food Chem 58:8004-11. 2010
    ..The contribution of the biopolymer as quencher of (1)O(2) was also investigated. The present results can be applied to the design of edible antioxidant microcapsules within the food and cosmetic industries...
  83. ncbi Extracellular Polymeric Substances diversity of biofilms grown under contrasted environmental conditions
    Monique Ras
    LBAE, Laboratoire de Biologie appliquée à l Agro alimentaire et à l Environnement, Institut Universitaire de Technologie, Universite Paul Sabatier Toulouse III, 24 Rue d Embaquès, 32000 Auch, France
    Water Res 45:1529-38. 2011
    ..This study brings new elements for designing EPS fractionation and shows that size distribution analysis is an interesting tool to relate EPS diversity with macro-scale characteristics of biofilms...
  84. ncbi From natural to designer self-assembling biopolymers, the structural characterisation of fibrous proteins & peptides using fibre diffraction
    Kyle Morris
    School of Life Sciences, John Maynard Smith Building, University of Sussex, Brighton, UK
    Chem Soc Rev 39:3445-53. 2010
    ..In the second part, we will discuss the advances in structure determination, with particular reference to the use of X-ray fibre diffraction...
  85. pmc Diterpenoid biopolymers: new directions for renewable materials engineering
    Matthew L Hillwig
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA
    Biopolymers 95:71-6. 2011
    ..Furthermore, this biosynthetic toolbox is continuously expanding, providing new possibilities for renewing dwindling stocks of naturally occurring resinite materials and engineering new materials for future applications...
  86. ncbi Extraction of extracellular polymeric substances from aerobic granule with compact interior structure
    Sunil S Adav
    Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
    J Hazard Mater 154:1120-6. 2008
    ..However, detailed study disproved the use of EEM results as a quantitative index of extracted EPS from sludge flocs or from granules...
  87. ncbi Evaluation of size exclusion chromatography (SEC) for the characterization of extracellular polymeric substances (EPS) in anaerobic granular sludges
    Stephane Simon
    Groupement de Recherche Eau Sol Environnement, Faculte des Sciences et Techniques, Universite de Limoges, 123, Avenue A Thomas, 87060 Limoges Cedex, France
    Bioresour Technol 100:6258-68. 2009
    ..This phenomenon was observed mainly for the largest and smallest molecules and molecules which display interactions with column packing...
  88. ncbi PHA synthase engineering toward superbiocatalysts for custom-made biopolymers
    Christopher T Nomura
    Department of Chemistry, State University of New York College of Environmental Science and Forestry, 121 Jahn Laboratory, Syracuse, NY 13210, USA
    Appl Microbiol Biotechnol 73:969-79. 2007
    ..This review covers the recent history of PHA synthase engineering and also summarizes studies that have utilized engineered PHA synthases...
  89. pmc FRET fluctuation spectroscopy of diffusing biopolymers: contributions of conformational dynamics and translational diffusion
    Kaushik Gurunathan
    Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287 5601, USA
    J Phys Chem B 114:980-6. 2010
    The use of fluorescence correlation spectroscopy (FCS) to study conformational dynamics in diffusing biopolymers requires that the contributions to the signal due to translational diffusion are separated from those due to conformational ..
  90. pmc F-actin, a model polymer for semiflexible chains in dilute, semidilute, and liquid crystalline solutions
    J Kas
    Division of Experimental Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biophys J 70:609-25. 1996
    ..We also report the novel direct observation of u-shaped defects, called hairpins, in the nematic domains...
  91. pmc Refolding dynamics of stretched biopolymers upon force quench
    Changbong Hyeon
    Department of Chemistry, Chung Ang University, Seoul 156 756, Republic of Korea
    Proc Natl Acad Sci U S A 106:20288-93. 2009
    Single-molecule force spectroscopy methods can be used to generate folding trajectories of biopolymers from arbitrary regions of the folding landscape...
  92. ncbi Nonlinear elasticity of composite networks of stiff biopolymers with flexible linkers
    C P Broedersz
    Department of Physics and Astronomy, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Phys Rev Lett 101:118103. 2008
    ..This model yields a crossover from a linear elastic regime to a highly nonlinear elastic regime that stiffens in a way quantitatively consistent with experiment...
  93. ncbi Identification and quantification of major organic foulants in treated domestic wastewater affecting filterability in dead-end ultrafiltration
    Xing Zheng
    Technische Universitat Berlin, Chair of Water Quality Control, Sekr KF 4, Strasse des 17 Juni 135, 10623 Berlin, Germany
    Water Res 43:238-44. 2009
    ..Mechanism analysis demonstrates that based on the delivered biopolymer load to membrane pore blocking or cake/gel fouling is the main fouling mechanism in the present experiment conditions...
  94. ncbi Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury
    Liudmila N Novikova
    Department of Integrative Medical Biology, Umea University, Sweden
    Curr Opin Neurol 16:711-5. 2003
    ..This article reviews recent experimental advances in the development of biosynthetic implants for repair of spinal cord injury...
  95. pmc LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thaliana
    Sung Soo Kim
    Department of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Plant Cell 22:4045-66. 2010
    ..These results show that hydroxylated α-pyrone polyketide compounds generated by the sequential action of ACOS5 and PKSA/B are potential and previously unknown sporopollenin precursors...
  96. pmc Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens
    A Bacon
    Vaccine Research Unit Medeva Group Development, Department of Biochemistry, Imperial College of Science and Technology, London SW7 2AY, United Kingdom
    Infect Immun 68:5764-70. 2000
    We have evaluated the ability of two carbohydrate biopolymers, chitosan and gellan, to enhance antibody responses to subunit influenza virus vaccines delivered to the respiratory tracts of mice...
  97. ncbi Asymmetrical flow field-flow fractionation technique for separation and characterization of biopolymers and bioparticles
    G Yohannes
    Laboratory of Analytical Chemistry, Department of Chemistry, P O Box 55, FIN 00014, University of Helsinki, Finland
    J Chromatogr A 1218:4104-16. 2011
    ..theoretical background of analyte retention and separation efficiency in FFF, followed by a comprehensive overview of the current status of asymmetrical flow FFF with selected applications in the field of biopolymers and bioparticles.
  98. ncbi Mass spectrometry in toxinology: a 21st-century technology for the study of biopolymers from venoms
    Pierre Escoubas
    Toxicon 47:609-13. 2006
    ..and appropriate ionization techniques have permitted the application of mass spectrometry to the analysis of biopolymers such as proteins, sugars and nucleic acids and have opened the door to a multiplicity of applications, and not ..
  99. ncbi Search of periodicities in primary structure of biopolymers: a general Fourier approach
    - Makeev VJu
    Engelgardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    Comput Appl Biosci 12:49-54. 1996
    We discuss a new convenient way to study periodical patterns in primary structures of biopolymers which appeared recently...
  100. ncbi Standards and guidelines for biopolymers in tissue-engineered medical products: ASTM alginate and chitosan standard guides. American Society for Testing and Materials
    M Dornish
    Pronova Biomedical a s, Oslo, Norway
    Ann N Y Acad Sci 944:388-97. 2001
    ..Together these two guides represent part of the effort on behalf of the ASTM and other interested parties to ensure quality and standardization in TEMPS...
  101. ncbi Unconventional salt trend from soft to stiff in single neurofilament biopolymers
    Roy Beck
    Departments of Materials and Physics, University of California Santa Barbara, Santa Barbara, California 93106, United States
    Langmuir 26:18595-9. 2010
    ..The results are in agreement with present X-ray and microscopy data yet present a theoretical challenge for polyampholyte interchain interactions...

Research Grants63

  1. Protein biomarkers of pulmonary hypertension in sickle cell disease
    Mark E McComb; Fiscal Year: 2013
    ..lead to changes in protein function, rates of turnover and in modulation of interactions with other proteins, biopolymers and ligands...
  2. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2013
    ..these results will help us understand the interactions of intracellular solutes with each other and with biopolymers which are a key determinant of amount of water in the cell, cell volume, biopolymer volume fraction and even ..
  3. Multifunctional nanoparticles for enhanced drug delivery to the lung
    HUGH DAVID SMYTH; Fiscal Year: 2013
    ..mode, (2) we prove that our nanoparticles can be heated and they act like nanoknives cutting through biopolymers such as DNA that causes CF mucus to be diffusion limiting, (3) we demonstrate also our ability to synthesize a ..
  4. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012
    ..without using harmful, volatile organic solvents and/or strong acid and base;(2) using only naturally occurring biopolymers, including polysaccharides and keratin, as support materials to strengthen the structure and expand the ..
  5. Protease Operated Depot for Delivery of GLP-1
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..This strategy leverages our previous experience in biomaterials development of recombinant ELP-based biopolymers that can be designed to undergo a phase transition in vivo, driven by body heat to form a highly viscous ..
  6. Structural origin of fibrin clot mechanical properties
    John W Weisel; Fiscal Year: 2012
    ..the research proposed in this application, the structural basis of the elastic and viscous properties of fibrin biopolymers is going to be examined using an integrated approach, which includes different levels of analysis, the ..
  7. Expanding the Genetic Alphabet by Design and Selection
    Floyd E Romesberg; Fiscal Year: 2013
    ..Expansion of the genetic alphabet would make possible the site-specific labeling of DNA and RNA - just as these biopolymers are receiving increased attention for applications ranging from novel materials to therapeutics...
  8. DNA and RNA Stability in Glycine Betaine, TMAO, and Urea Solutions: Correlating S
    JEFFREY JAMES contact SCHWINEFUS; Fiscal Year: 2010
    ..Cellular biochemical reactions involving nucleic acids occur in aqueous solutions of salts, cosolutes, and biopolymers, such as proteins...
  9. Ultrafast Spectroscopic Methods to Probe Photodamage and Unfolding in Biopolymers
    David W McCamant; Fiscal Year: 2012
    ..With Specific Aim #2, we will develop new methodologies to impulsively initiate thermal unfolding of biopolymers. This will allow the numerous tools of time-resolved spectroscopy, which currently have applications limited to ..
  10. DnaK Protein Inhibitor Antimicrobials
    Michael Sturgess; Fiscal Year: 2003
    ..Many antibacterial peptides have intracellular target biopolymers, but because the peptides have to reach the cell interior, their action on bacterial and host cell membranes ..
  11. Molecular Mechanisms of L. monocytogenes Adhesion Through Surface Biopolymers
    NEHAL IBRAHIM ABU LAIL; Fiscal Year: 2010
    ..of Listeria monocytogenes to surfaces is limited by the lack of molecular-scale studies on how the surface biopolymers of L. monocytogenes affect their attachment to surfaces...
  12. PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRY
    PAUL WARREN STERNBERG; Fiscal Year: 2013
    ..regulation of gene expression, signal transduction, eukaryotic cell biology, synthetic biological circuits, biopolymers, and protein and cell structure...
  13. 2010 Biopolymers Gordon Research Conference
    Dorothy Beckett; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Funds are requested for partial support of the 2010 Biopolymers Gordon Research Conference...
  14. Phi29 Motor Nanopore for Single Molecule Sensing
    Peixuan Guo; Fiscal Year: 2013
    ..of the phi29 DNA packaging motor as a highly sensitive device for capture and fingerprinting of chemicals and biopolymers in real time at single molecule resolution using electrophysiological assays...
  15. Software for Homology Modeling of Ribosomes
    FREDRICK OTIENO SIJENYI; Fiscal Year: 2010
    ..of RNA-123 is extended to be able to homology model an entire ribosome, it can be easily adapted to model biopolymers, DNA, and carbohydrates as well as their complexes with each other, RNA, and drug-like small molecules...
  16. Enzyme Mis-Metallation, Consequences and Opportunities
    Anne Frances Miller; Fiscal Year: 2010
    ..chemical transformations involved in antibiotic biosynthesis, metabolism of xenobiotics, construction of biopolymers, and more...
  17. Sensitivity enhancement in solution NMR through dynamic nuclear polarization
    A Joshua Wand; Fiscal Year: 2013
    ..The inability to investigate protens and other biopolymers at well below sub-millimolar concentrations and using sub-micromole amounts presents severe limitations on ..
  18. Microenivironment Dimensionality Modulates Neuronal Signaling
    Jennie B Leach; Fiscal Year: 2012
    ..from two-dimensional (2D) culture into three-dimensional (3D) systems has been a major hurdle in the use of biopolymers for tissue repair applications...
  19. Dental Nanocomposite Materials Using Functional Polymer and HAP Nanocrystals
    Seung Wuk Lee; Fiscal Year: 2009
    ..goal of this proposal is to develop novel dental nanocomposite materials using hydroxyapatite nanocrystals and biopolymers containing two motifs identified by natural and artificial evolution processes...
  20. Increasing the Utility of Polymerases by Directed Evolution
    Floyd E Romesberg; Fiscal Year: 2013
    ..specificity of natural polymerases limits their potential applications to those involving the fully natural biopolymers, which are unsuitable for many diagnostic, therapeutic, and DNA sequencing applications...
  21. Study Protein-Nanomaterial Interactions and Their Impacts on Protein Activities
    Wenwan Zhong; Fiscal Year: 2011
    ..inorganic core materials, nanomaterials interact with biological systems differently than small molecules or biopolymers, objects we have previous knowledge of...
  22. Engineered Nanopores for Single-Molecule Stochastic Sensing
    Liviu Movileanu; Fiscal Year: 2013
    ..at developing engineered nanopore-based biosensors that feature a wider pore diameter to accommodate bulky biopolymers, including proteins, double-stranded DNA, and their complexes with the interacting ligands...
  23. Novel Multimodal Selectors for CE and HPLC
    Apryll Stalcup; Fiscal Year: 2009
    ..work addresses the urgent need for improved technologies for novel and more universal separation strategies for biopolymers (e.g...
  24. Adenosine-releasing brain implants for epilepsy therapy
    Detlev Boison; Fiscal Year: 2011
    ..5) The combination of biopolymers and engineered stem cells promotes the release of adenosine...
  25. Carbohydrate force fields for structure, dynamics and molecular recognition
    Alexander D MacKerell; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Carbohydrates are the most abundant biopolymers on earth. Their biological functions include fuels, energy storage, metabolic intermediates, structural roles and, importantly, molecular recognition...
  26. A Novel SFM-based Method for Studying Single Molecule Dynamics
    Sean B Andersson; Fiscal Year: 2012
    ..In this project we propose to develop a novel method for studying the dynamics of single molecules moving on biopolymers. The method is a new control approach centered on the concept of particle tracking with a scanning force ..
  27. A Novel SFM-based Method for Studying Single Molecule Dynamics
    Sean B Andersson; Fiscal Year: 2011
    ..In this project we propose to develop a novel method for studying the dynamics of single molecules moving on biopolymers. The method is a new control approach centered on the concept of particle tracking with a scanning force ..
  28. Bone Targeting Peptides for the Prevention and Treatment of Infection
    HANNE GRON; Fiscal Year: 2009
    ..to synthetic surfaces (metals, plastics, polymers, etc.) or tissues. These specifying and grafting biopolymers are termed "interfacial biomaterials" (IFBMs)...
  29. Thermally targeted drug delivery by elastin biopolymers
    Ashutosh Chilkoti; Fiscal Year: 2013
    ....
  30. Single Molecule Protein and Biopolymer Folding Dynamics
    Shimon Weiss; Fiscal Year: 2003
    ..methodology to follow conformational dynamics of individual fluorescently-labeled proteins and other biopolymers. In contrast to ensemble methods, single-molecule methods provide information on fluctuations, distributions ..
  31. APBS: Nanoscale Biomolecular Electrostatics Software
    Nathan A Baker; Fiscal Year: 2013
    ..The structures of proteins and other biopolymers are being determined at an increasing rate through structural genomics and other efforts while specific ..
  32. Molecular Principles of FGF-HSGAG Interactions
    Ram Sasisekharan; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): With DNA (RNA) and proteins, two major biopolymers, major scientific effort has been aimed at understanding how sequence dictates function. The third major biopolymer is the polysaccharides...
  33. Dendritic Biomaterials for Oral Delivery of Chemotherapeutics
    Hamid Ghandehari; Fiscal Year: 2010
    ..However, the large size of most biopolymers necessitates administration via the parenteral route...
  34. MASS SPECTROMETRY RESOURCE FOR BIOLOGY AND MEDICINE
    Catherine E Costello; Fiscal Year: 2013
    ..is the development and application of advanced, mass spectrometry-based methods for the characterization of biopolymers that are relevant to human health and disease...
  35. Purchase of a Q-TOF LC/MS System
    Michael C Fitzgerald; Fiscal Year: 2010
    ..variety of sample types, including small organic molecules as well as both synthetic and naturally occurring biopolymers. The Chemistry Department's need to add a Q-TOF mass spectrometer system to its Instrument Facility is ..
  36. In Situ Polymerizing Biodendrimer Scaffolds for Articular Cartilage Repair
    ROBERT NASLUND; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Biodendrimers are a new class of well-defined modular biopolymers prepared from monomers that are natural metabolites or known to be biocompatible, that can be custom-designed to provide ..
  37. LASER-EXCITED RAMAN SPECTROSCOPY OF BIOPOLYMERS
    Nai Teng Yu; Fiscal Year: 1991
    ....
  38. Development of hyperpolarized solid state NMR spectroscopy
    Chan Gyu Joo; Fiscal Year: 2013
    ..NMR: 1) significant reduction in measurement time (which will lead to the study of higher molecular weight biopolymers), 2) improved detection limit, and 3) hyperpolarization at high temperature in an ambient sample condition...
  39. STRUCTURALLY NEW BIOPOLYMERS DERIVED FROM AMINO ACIDS
    Joachim Kohn; Fiscal Year: 1992
    ..In addition, several backbone-modified poly(amino acids) will be charactrized in sufficient detail to evaluate the potential of these materials for medical applications...
  40. Chemical Structure of Anthrax Spore Polysaccharide
    Julia Wang; Fiscal Year: 2005
    ..Because polysaccharides are typically highly stable biopolymers of poor immunogenicity, we hypothesize that EPS plays significant roles in protecting the survival of spores ..
  41. Ophthalmic Sealants for Corneal Surgeries
    MICHAEL CARNAHAN; Fiscal Year: 2005
    Biodendrimers are a new class of well-defined modular biopolymers prepared from monomers that are natural metabolites or known to be biocompatible, that can be custom-designed to provide a unique hydrogel sealant for repairing cornea! ..
  42. Prevention and Treatment of Oral Biofilms and Related Oral Disease by Soluble Chi
    SHENDA BAKER; Fiscal Year: 2009
    ..We have developed derivatives of natural biopolymers that have demonstrable effectiveness in clumping a wide spectrum of bacteria and preventing the adhesion of ..
  43. EPITHELIALIZATION OF TISSUE ENGINEERED CORNEAS
    JEAN JACOB; Fiscal Year: 2003
    ..the surfaces of these materials have not improved the epithelial cell response because 1) adsorption of these biopolymers to synthetic materials is non-specific and therefore they lay down on the surface in many different ..
  44. Chlipoplex Nanoparticle Prophylactics for RSV Infection
    Shyam Mohapatra; Fiscal Year: 2004
    ..The Transgenex Therapeutics (TGT), a start-up biotech company is developing biopolymers, called chlipoplexes, which protect the pDNAs and target them to the epithelial cells, macrophages or dendritic ..
  45. MUTATIONAL EFFECTS ON COLLAGEN'S STRUCTURE & STABILITY
    TERI KLEIN; Fiscal Year: 2003
    ..analysis of sequence information (bioinformatics) allows for more direct studies at a molecular level of large biopolymers and fibril proteins such as collagen...
  46. Endomyocardial Catheter Delivery of Artificial Biopolymer Matrices for Enhanced C
    Didier Rouy; Fiscal Year: 2009
    ..Our group has developed a catheter based technology that enables accurate and controlled delivery of biopolymers, with or without cells, into target zones in the myocardium...
  47. PENTENYL GLYCOSIDES--TRANSFORMATIONS AT ANOMERIC CENTER
    Bert Fraser Reid; Fiscal Year: 1999
    ..investigator states that the importance of the project stems from the fact that of the three major families of biopolymers, proteins, oligonucleotides and oligosaccharides, the last is the least well understood because their isolation,..
  48. Development of photoaffinity ligands for the alpha3beta4 nicotinic acetylcholine
    Faming Jiang; Fiscal Year: 2010
    ..labeling (PAL) has been a powerful approach for identifying subunits and mapping the active sites of biopolymers such as DNA and protein molecules, and it enables the direct probing of a target protein through a covalent ..
  49. Numerical Methods that Solve the PBE for Biomolecular Electrostatics
    ALEXANDER BOSCHITSCH; Fiscal Year: 2007
    ..Conduct preliminary studies using the fast mPBE solver to assess the salt-dependent behavior of complex-shape biopolymers in multivalent salt solutions. Research Design...
  50. HIGH CONTENT SCREENING OF 3D CULTURED CANCER CELLS
    TOM ZAREMBINSKI; Fiscal Year: 2013
    ..as it is specifically recognized by cells via the CD44 and RHAMM receptors (unlike PEG, alginate, or other biopolymers), and can be selectively degraded by the hyaluronidases characteristic of invasive cancers...
  51. Thermally Targeted Delivery of DOX
    RAYMOND BUDDE; Fiscal Year: 2007
    ..The amino acid sequence of the designed polypeptides is based on elastin-like polypeptide (ELP) biopolymers which are soluble in aqueous solution at physiological temperature (37 [unreadable]C), but aggregate when the ..
  52. A New Method for Sterilizing Biomedical Materials
    PENNY STARKEY; Fiscal Year: 2002
    ..to a variety of biomedical materials, including thermally and hydrolytically sensitive polymers, as well as biopolymers. The method will find application in sterilizing numerous biomedical materials...
  53. NEW BIOPOLYMERS FOR MEDICAL APPLICATIONS
    Simon Williams; Fiscal Year: 1993
    The long-term objectives of this research are to use a biological catalyst known as a polymerase, to create new biopolymers and identify those with useful properties for the biomedical industry...
  54. HEPARIN SEQUENCES FOR APPLICATIONS TO HEMOSTASIS
    PETER SEEBERGER; Fiscal Year: 2002
    DESCRIPTION: Heparin-like glycosaminoglycans (HLGAGs) are the most acidic naturally occurring biopolymers, found in the extracellular matrices...
  55. GENETICALLY ENGINEERED POLYMER FOR GENE DELIVERY
    HARNIDREZA GHANDEHARI; Fiscal Year: 1999
    ..Through sequence-specific design, this technology provides a unique means to synthesize biopolymers with sell defined properties such as charge periodicity, molecular weight, and three dimensional structure, and ..
  56. Novel 3-dimensional platform for high-throughput glycomics discovery
    Xichun Zhou; Fiscal Year: 2007
    ..Glycomics is an emerging field that focuses on studying the interactions of carbohydrates with other biopolymers, particularly proteins, to gain a better understanding of the roles of carbohydrates in biological processes...
  57. NEW APPROACHES TO ANALYSIS OF BIOPOLYMERS
    Alexander Varshavsky; Fiscal Year: 1990
    ..The results of the proposed studies should be of immediate utility for molecular biological studies on cancer as well as for many other fields of biochemical research...
  58. Targeted Delivery of c-Myc Inhibitory Polypeptides
    Drazen Raucher; Fiscal Year: 2007
    ..The amino acid sequence of the designed polypeptides is based on elastin-like (ELP) biopolymers which are soluble in aqueous solution below physiological temperature 37 degrees C, but aggregate when the ..
  59. IONIC DISTRIBUTIONS IN POLYNUCLEOTIDE SOLUTIONS
    PETER ROSSKY; Fiscal Year: 1992
    The strong mutual interaction between biopolymers and their solution environment exerts a widely appreciated influence on the structures and function of such macromolecules. This is particularly true of the highly charged polynucleotides...
  60. DELIVERY OF BIOPOLYMERS USING CATIONIC PEPTIDES
    Lawrence Steinman; Fiscal Year: 1999
    The long term objective of this proposal is to use short, cationic peptides as a efficient method of delivering biopolymers, such as intact autoantigens, immunodominant peptides, and antisense oligonucleotides into the cytoplasm of ..
  61. OPTICAL ROTATORY POWER OF BIOPOLYMERS
    JEN YANG; Fiscal Year: 1991
    ..A combination of limited proteolysis and recombinant DNA technique will provide useful information about this synaptic enzyme...
  62. STRUCTURE AND FUNCTION OF SYNTHETIC GLYCOSAMINOGLYCANS
    PETER SEEBERGER; Fiscal Year: 2004
    Heparin-like glycosaminoglycans (HLGAGs) are the most acid naturally occurring biopolymers. These complex polysaccharides, found in the extracellular matrix, play a key role in regulating the biological activity of several proteins in ..
  63. Ligand-Binding in the Reaction Mechanism of DAO
    GEORGE GASSNER; Fiscal Year: 2004
    ..and nucleic acid-binding interactions of DAO and the modulation of its catalytic activity associated with these biopolymers. The primary structure, glycosylation, cofactor content, specific activity, and substrate specificities of the ..