- Design and development of polymers for gene delivery
Daniel W Pack
Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
Nat Rev Drug Discov 4:581-93. 2005
..In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function ..
- Porosity of 3D biomaterial scaffolds and osteogenesis
Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Biomaterials 26:5474-91. 2005
..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
- Toxicity of cationic lipids and cationic polymers in gene delivery
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China
J Control Release 114:100-9. 2006
..Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce ..
- Synthetic biodegradable polymers as orthopedic devices
J C Middleton
Birmingham Polymers, Inc, AL 35211, USA
Biomaterials 21:2335-46. 2000
..In this article we will focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired...
- Polymers for drug delivery systems
William B Liechty
Department of Chemical Engineering, University of Texas, Austin, TX 78712 1062, USA
Annu Rev Chem Biomol Eng 1:149-73. 2010
b>Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and ..
- Synthetic genetic polymers capable of heredity and evolution
Vitor B Pinheiro
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Science 336:341-4. 2012
Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown...
- Long-circulating and target-specific nanoparticles: theory to practice
S M Moghimi
Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
Pharmacol Rev 53:283-318. 2001
..With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states...
- Polymer vesicles
Dennis E Discher
School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104 6393, USA
Science 297:967-73. 2002
..including stability, fluidity, and intermembrane dynamics, are greatly influenced by characteristics of the polymers. Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but ..
- Block copolymer micelles for drug delivery: design, characterization and biological significance
Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
Adv Drug Deliv Rev 47:113-31. 2001
..As an important perspective on carrier systems based on polymeric micelles, their feasibility as non-viral gene vectors is also summarized in this review article...
- Biodegradable, elastic shape-memory polymers for potential biomedical applications
mnemoScience GmbH, Pauwelsstrabetae 19, D 52074 Aachen, Germany
Science 296:1673-6. 2002
..This report describes a group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature...
- Bioreducible polymers for gene silencing and delivery
Department of Chemistry, Pohang University of Science and Technology, Korea
Acc Chem Res 45:1100-12. 2012
..Among the numerous multifunctional polymers that have been designed and evaluated as gene delivery vectors, polymers with redox-sensitive (or bioreducible) ..
- Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Nano Lett 6:2427-30. 2006
..In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles...
- Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction
Infection Biology, Department of Biomedicine, University Hospital, CH 4056 Basel, Switzerland
Antimicrob Agents Chemother 54:4208-18. 2010
..This is the first report investigating the global metabolic effects of silver in the context of a therapeutic application. We anticipate that the compounds presented here open a new treatment field with a high medical impact...
- Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
Pedro M M Mesquita
Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Infect Dis 200:599-608. 2009
..The lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present experiments were designed to evaluate the predictive value of in vitro models of microbicide safety...
- Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group
Department of Physics, University of Michigan, Ann Arbor, 48109, USA
Langmuir 21:10348-54. 2005
Polycationic polymers are used extensively in biology to disrupt cell membranes and thus enhance the transport of materials into the cell...
- Functional supramolecular polymers
Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Tokyo, Japan
Science 335:813-7. 2012
Supramolecular polymers can be random and entangled coils with the mechanical properties of plastics and elastomers, but with great capacity for processability, recycling, and self-healing due to their reversible monomer-to-polymer ..
- The chemistry and applications of antimicrobial polymers: a state-of-the-art review
El Refaie Kenawy
Department of Chemistry, Polymer Research Group, Faculty of Science, University of Tanta, Tanta 31527, Egypt
Biomacromolecules 8:1359-84. 2007
..The use of antimicrobial polymers offers promise for enhancing the efficacy of some existing antimicrobial agents and minimizing the environmental ..
- Cationic polymers and their therapeutic potential
Sangram Keshari Samal
Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, S4 bis, B 9000 Ghent, Belgium
Chem Soc Rev 41:7147-94. 2012
The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and ..
- Microtubule polymerization dynamics
Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
Annu Rev Cell Dev Biol 13:83-117. 1997
..In this review, we first describe progress toward understanding the mechanism of dynamic instability of pure tubulin and then discuss the function and regulation of microtubule dynamic instability in living cells...
- Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
Min Suk Shim
Department of Chemical Engineering and Materials Science, University of California, Irvine, 92697, USA
Adv Drug Deliv Rev 64:1046-59. 2012
- PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
MRC Clinical Trials Unit, London, UK
Lancet 376:1329-37. 2010
..PRO2000 vaginal gel was efficacious against HIV-1 transmission in studies in macaques; we aimed to assess efficacy and safety of 2% and 0·5% PRO2000 gels against vaginal HIV-1 transmission in women in sub-Saharan Africa...
- Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
Catherine M Cowan
The Department of Surgery, Stanford University School of Medicine, Stanford University, 257 Campus Drive, Stanford, California 94305, USA
Nat Biotechnol 22:560-7. 2004
..The contribution of implanted cells to new bone formation was 84-99% by chromosomal detection. These data show that ADAS cells heal critical-size skeletal defects without genetic manipulation or the addition of exogenous growth factors...
- Gold nanocages covered by smart polymers for controlled release with near-infrared light
Mustafa S Yavuz
Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
Nat Mater 8:935-9. 2009
..This system works well with various effectors without involving sophisticated syntheses, and is well suited for in vivo studies owing to the high transparency of soft tissue in the near-infrared region...
- Catechol polymers for pH-responsive, targeted drug delivery to cancer cells
Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA
J Am Chem Soc 133:11850-3. 2011
- Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy
Joshua A Gustafson
Department of Bioengineering, University of Utah, Salt Lake City, USA
Adv Drug Deliv Rev 62:1509-23. 2010
Silk-elastinlike protein polymers (SELPs) are recombinant polymers designed from silk fibroin and mammalian elastin amino acid repeats...
- Tuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives
M Firat Ilker
Department of Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
J Am Chem Soc 126:15870-5. 2004
..hemolytic activity against human red blood cells were measured and compared to determine the selectivity of the polymers for bacterial over mammalian cells...
- Synergistic activity of hydrophilic modification in antibiotic polymers
Philippe H Sellenet
Department of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, USA
Biomacromolecules 8:19-23. 2007
..A hydrophilicity based design-paradigm can significantly improve both the efficacy and the biocompatibility of antibacterial materials...
- Dynamics of membrane protein/amphipol association studied by Förster resonance energy transfer: implications for in vitro studies of amphipol-stabilized membrane proteins
Laboratoire de Physico Chimie Moléculaire des Membranes Biologiques, UMR 7099, Centre National de la Recherche Scientifique, and Institut de Biologie Physico Chimique, Universite Paris 7, 13 rue Pierre et Marie Curie, F 75005 Paris, France
Biochemistry 46:10392-404. 2007
Amphipols (APols) are short amphipathic polymers that can substitute for detergents to keep membrane proteins (MPs) water-soluble while stabilizing them biochemically...
- Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
Laboratory of Microbiology and Oncology, Sojo University, Kumamoto, Japan
Eur J Pharm Biopharm 71:409-19. 2009
- Mucoadhesive polymeric platforms for controlled drug delivery
Gavin P Andrews
School of Pharmacy, The Queen s University of Belfast, Belfast, Ireland
Eur J Pharm Biopharm 71:505-18. 2009
..Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer networks to more specific second-generation systems based on lectin, thiol and various other adhesive functional groups...
- Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Biomaterials 28:869-76. 2007
..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
- Entropy-driven spatial organization of highly confined polymers: lessons for the bacterial chromosome
Stichting voor Fundamenteel Onderzoek der Materie FOM Institute for Atomic and Molecular Physics AMOLF, Kruislaan 407, 1098 SJ, Amsterdam, The Netherlands
Proc Natl Acad Sci U S A 103:12388-93. 2006
..with bacterial chromosome segregation, namely the spatial organization of highly confined, self-avoiding polymers (of nontrivial topology) in a rod-shaped cell-like geometry...
- Amphiphilic block copolymers for drug delivery
Monica L Adams
Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53705 2222, USA
J Pharm Sci 92:1343-55. 2003
..The purpose of this minireview is to provide a concise, yet detailed, introduction to the use of ABCs and polymeric micelles as delivery agents as well as to highlight current and past work in this area...
- Biodegradable polymers for the environment
Richard A Gross
Polytechnic University, National Science Foundation Center for Biocatalysis and Bioprocessing of Macromolecules, Six Metrotech Center, Brooklyn, NY 11201, USA
Science 297:803-7. 2002
Biodegradable polymers are designed to degrade upon disposal by the action of living organisms...
- Microbial production of building block chemicals and polymers
Jeong Wook Lee
Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
Curr Opin Biotechnol 22:758-67. 2011
..b>Polymers we use everyday can also be produced either by direct fermentation or by polymerization of monomers that are ..
- Polyhydroxyalkanoates as a source of chemicals, polymers, and biofuels
Protein Science Laboratory of the Ministry of Education, Dept of Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
Curr Opin Biotechnol 22:768-74. 2011
..putida makes it possible to achieve precise substrate based design of PHA homopolymers, copolymers, and block polymers, allowing the study of structure-property relationship in a clear way...
- Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
C E Kast
Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
Biomaterials 22:2345-52. 2001
..on the pH-value and the weight ratio of polymer to TGA during the coupling reaction the resulting thiolated polymers, the so-called thiomers, displayed 6.58, 9.88, 27.44, and 38.23 micromole thiol groups per gram polymer...
- Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
Si Shen Feng
Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
Curr Med Chem 11:413-24. 2004
..Nanoparticles of biodegradable polymers can provide an ideal solution to such an adjuvant problem and realize a controlled and targeted delivery of the ..
- A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency
Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Cambridge, UK
Hepatology 52:1078-88. 2010
..severe Z deficiency allele (Glu342Lys) causes the protein to undergo a conformational transition and form ordered polymers that are retained within hepatocytes. This causes neonatal hepatitis, cirrhosis, and hepatocellular carcinoma...
- Chitosan-graft-polyethylenimine as a gene carrier
Hu Lin Jiang
School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
J Control Release 117:273-80. 2007
Chitosans have been proposed as biocompatible alternative cationic polymers that are suitable for non-viral delivery. However, the transfection efficiency of chitosan-DNA nanoparticles is still very low...
- The dawning era of polymer therapeutics
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
Nat Rev Drug Discov 2:347-60. 2003
- Self-assembly at all scales
George M Whitesides
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Science 295:2418-21. 2002
..The concept of self-assembly is used increasingly in many disciplines, with a different flavor and emphasis in each...
- Polymer conjugates as anticancer nanomedicines
Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
Nat Rev Cancer 6:688-701. 2006
..There is growing optimism that ever more sophisticated polymer-based vectors will be a significant addition to the armoury currently used for cancer therapy...
- Photodegradable hydrogels for dynamic tuning of physical and chemical properties
April M Kloxin
Department of Chemical and Biological Engineering, University of Colorado, 424 UCB ECCH 111, Boulder, CO 80309, USA
Science 324:59-63. 2009
- Soft porous crystals
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto 615 8510, Japan
Nat Chem 1:695-704. 2009
..Recent developments on porous coordination polymers (or metal-organic frameworks) have provided the inherent properties that combine these features...
- Polymer-supported membranes as models of the cell surface
Department of Physics, Technical University of Munich, D 85748 Garching, Germany
Nature 437:656-63. 2005
..Particularly exciting opportunities arise when these systems are coupled with advanced semiconductor technology...
- Polymers in small-interfering RNA delivery
Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, Pohang, Korea
Nucleic Acid Ther 21:133-47. 2011
..that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and ..
- Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability
Program in Applied Physics, Department of Chemistry, and Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
Bioconjug Chem 17:728-34. 2006
Interactions of polycationic polymers with supported 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers and live cell membranes (KB and Rat2) have been investigated using atomic force microscopy (AFM), cytosolic enzyme ..
- Folate-functionalized polymeric micelle as hepatic carcinoma-targeted, MRI-ultrasensitive delivery system of antitumor drugs
Department of Radiology, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
Biomed Microdevices 10:693-700. 2008
- Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer for coronary revascularisation (LEADERS): a randomised non-inferiority trial
Department of Cardiology, and CTU Bern, Bern University Hospital, Bern, Switzerland
Lancet 372:1163-73. 2008
..We compared the safety and efficacy of a biolimus-eluting stent (with biodegradable polymer) with a sirolimus-eluting stent (with durable polymer)...
- Antibacterial studies of cationic polymers with alternating, random, and uniform backbones
Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, United States
ACS Chem Biol 6:590-9. 2011
Antibacterial polymers have potential as pharmaceuticals and as coatings for implantation devices...
- Dramatic tuning of carbon dioxide uptake via metal substitution in a coordination polymer with cylindrical pores
Stephen R Caskey
Department of Chemistry and Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan, 48109 1055, USA
J Am Chem Soc 130:10870-1. 2008
A series of four isostructural microporous coordination polymers (MCPs) differing in metal composition is demonstrated to exhibit exceptional uptake of CO2 at low pressures and ambient temperature...
- Functional metagenomics unveils a multifunctional glycosyl hydrolase from the family 43 catalysing the breakdown of plant polymers in the calf rumen
CSIC, Institute of Catalysis, Madrid, Spain
PLoS ONE 7:e38134. 2012
Microbial communities from cow rumen are known for their ability to degrade diverse plant polymers at high rates...
- The use of amphipols as universal molecular adapters to immobilize membrane proteins onto solid supports
Unite Mixte de Recherche 7099, Centre National de la Recherche Scientifique and Université Paris 7, Institut de Biologie Physico Chimique, Centre National de la Recherche Scientifique, Federated Research Institute 550, Paris, France
Proc Natl Acad Sci U S A 106:405-10. 2009
..for immobilizing functional, unmodified integral membrane proteins onto solid supports, thanks to amphipathic polymers called "amphipols...
- Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering
Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576
Biomaterials 26:2603-10. 2005
..Based on the experimental results, the aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering...
- Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach
Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Am Chem Soc 130:9836-43. 2008
..Using amphiphilicity, monomer feed ratio, and molecular weight as parameters, polymers with 533 times higher selectivitiy (selecitviy = hemolytic concentration/minimum inhibitory concentration) for ..
- Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Gastroenterology 137:673-81. 2009
..Hepatitis C virus (HCV) gains entry into susceptible cells by interacting with cell surface receptor(s). Viral entry is an attractive target for antiviral development because of the highly conserved mechanism...
- In vitro biocompatibility studies of antibacterial quaternary polymers
Thomas R Stratton
School of Materials Engineering, Purdue University, 701 West Stadium Avenue, West Lafayette, Indiana 47907 2044, USA
Biomacromolecules 10:2550-5. 2009
..We have shown that these copolymers are biocompatible at concentrations above their minimum bactericidal concentrations, leading to selectivity values that compare well with other microbicidal products...
- Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency
Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK
Hepatology 57:2049-60. 2013
Point mutants of alpha1 -antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma...
- De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications
Gregory N Tew
Department of Chemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6059, USA
Acc Chem Res 43:30-9. 2010
..Finally, we apply the principles discovered through this work to the design of inexpensive antimicrobial polymers and materials.
- Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro
Respiratory Medicine Unit and Neurology Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, United Kingdom
J Biol Chem 277:17367-73. 2002
..9 and 56.6 degrees C, respectively) and more readily formed loop-sheet polymers under physiological conditions...
- Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
Adv Drug Deliv Rev 55:329-47. 2003
..Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed...
- Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise
Pharmaceutical Biotechnology, Center for System based Drug Research, Ludwig Maximilians Universitat Munchen, Germany
Acc Chem Res 45:1005-13. 2012
..For example, cationic polymers can reversibly package one or more siRNA molecules into nanoparticle cores to protect them against a degradative ..
- Improved safety and reduction in stent thrombosis associated with biodegradable polymer-based biolimus-eluting stents versus durable polymer-based sirolimus-eluting stents in patients with coronary artery disease: final 5-year report of the LEADERS (Limus
Patrick W Serruys
Thoraxcenter, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands
JACC Cardiovasc Interv 6:777-89. 2013
..This study sought to report the final 5 years follow-up of the landmark LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) trial...
- In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models
Wesley E Smith
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, United States
ACS Nano 6:9475-84. 2012
..Thus, further in vivo studies are warranted to ensure that TOPO-PMAT-coated Qdots used in biomedical applications do not induce inflammatory responses as a consequence of hepatic uptake...
- Polymers for gene delivery: current status and future perspectives
M R Rekha
Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
Recent Pat DNA Gene Seq 6:98-107. 2012
..Hence there is a need for developing non-viral vectors which can really be used for clinical applications. Polymers are a versatile group of molecules which can be modified and designed or engineered according to the end needs of ..
- Ocular drug delivery system: a reference to natural polymers
Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India
Expert Opin Drug Deliv 9:837-61. 2012
..The natural polymers have represented the potential to deliver drugs topically through the limited precorneal area and release over a ..
- Combinatorial discovery of polymers resistant to bacterial attachment
Andrew L Hook
Laboratory of Biophysics and Surface Analysis, University of Nottingham, Nottingham, UK
Nat Biotechnol 30:868-75. 2012
..These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have ..
- Nanoporous polymers for hydrogen storage
University of California Berkeley, 94720 1460, USA
Small 5:1098-111. 2009
..In this work, progress towards hydrogen storage with nanoporous materials in general and porous organic polymers in particular is critically reviewed...
- Biologically responsive polymeric nanoparticles for drug delivery
Yolonda L Colson
Division of Thoracic Surgery, Department of Surgery, Brigham and Women s Hospital, Boston MA 02215, USA
Adv Mater 24:3878-86. 2012
- Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition
Sviatoslav N Bagriantsev
Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
Mol Biol Cell 19:2433-43. 2008
..exist in different heritable conformations, called "variants," and they are composed of detergent-resistant Sup35 polymers, which may be closely associated with themselves, other proteins, or both...
- "Bite-and-Switch" approach using computationally designed molecularly imprinted polymers for sensing of creatinine
Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire MK45 4DT, UK
Biosens Bioelectron 16:631-7. 2001
..has been demonstrated previously for the detection of creatine using creatine-imprinted molecularly imprinted polymers (MIPs) Since MIPs created using traditional methods were unable to differentiate between creatine and creatinine, ..
- A combinatorial polymer library approach yields insight into nonviral gene delivery
Jordan J Green
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Acc Chem Res 41:749-59. 2008
..This Account describes an alternative strategy to viral gene delivery: the design of biodegradable polymers that are able to deliver DNA like a synthetic virus...
- Electrochemical sensor for dopamine based on a novel graphene-molecular imprinted polymers composite recognition element
Engineering Laboratory for Modern Analytical Techniques, c o State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, Jilin, PR China
Biosens Bioelectron 28:291-7. 2011
A novel composite of graphene sheets/Congo red-molecular imprinted polymers (GSCR-MIPs) was synthesized through free radical polymerization (FRP) and applied as a molecular recognition element to construct dopamine (DA) electrochemical ..
- Technological and biological evaluation of tablets containing different strains of lactobacilli for vaginal administration
Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
Eur J Pharm Biopharm 50:389-95. 2000
..Three different retarding polymers were tested, and all the formulations and tablets were evaluated in terms of technological processability, ..
- Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
Structure 16:1345-56. 2008
..Among the core yeast ESCRT-III subunits, Snf7 and Vps24 spontaneously form ordered polymers in vitro...
- Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
Department of Pharmaceutics and Biopharmacy, Philipps University, Ketzerbach 63, 35032 Marburg, Germany
Adv Drug Deliv Rev 54:715-58. 2002
..This review will introduce the most important cationic polymers used as non-viral vectors for gene and oligonucleotide delivery and will summarize strategies for the targeting ..
- Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
Islamic Azad University, Najafabad Branch, Isfahan, Iran
J Tissue Eng Regen Med 5:e17-35. 2011
..shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering...
- Polymers of intrinsic microporosity (PIMs): organic materials for membrane separations, heterogeneous catalysis and hydrogen storage
Neil B McKeown
School of Chemistry, Cardiff University, Cardiff, CF10 3AT, UK
Chem Soc Rev 35:675-83. 2006
..describes recent research directed towards the synthesis of polymer-based organic microporous materials termed Polymers of Intrinsic Microporosity (PIMs)...
- Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
Biomaterials 33:1627-39. 2012
..Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy.
- Recent advances in the development of semiconducting DPP-containing polymers for transistor applications
Christian B Nielsen
Department of Chemistry and Centre for Plastic Electronics, Imperial College London, London SW7 2AZ, United Kingdom
Adv Mater 25:1859-80. 2013
This progress report summarizes the numerous DPP-containing polymers recently developed for field-effect transistor applications including diphenyl-DPP and dithienyl-DPP-based polymers as the most commonly reported materials, but also ..
- Mechanisms underlying molecularly imprinted polymer molecular memory and the role of crosslinker: resolving debate on the nature of template recognition in phenylalanine anilide imprinted polymers
Gustaf D Olsson
Bioorganic and Biophysical Chemistry Laboratory, School of Natural Sciences, Linnaeus University, SE 391 82 Kalmar, Sweden
J Mol Recognit 25:69-73. 2012
..for phenylalanine anilide imprinted co-(ethylene glycol dimethacrylate-methacrylic acid) molecularly imprinted polymers have been employed to investigate the mechanistic basis for template selective recognition in these systems...
- Zwitterionic polymer-based platform with two-layer architecture for ultra low fouling and high protein loading
Chun Jen Huang
Department of Chemical Engineering, University of Washington, Seattle, Washington 98195 1750, USA
Anal Chem 84:3440-5. 2012
..disulfide (TED) and water in the reaction were varied to regulate the packing density and chain length of polymers, respectively, for the second pCB layer...
- Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Biomacromolecules 11:2700-6. 2010
..this study, we evaluated the induction of the ABC phenomenon using nanoparticles coated with various hydrophilic polymers instead of PEG...
- Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels
Andrew S Mikhail
Leslie Dan Faculty of Pharmacy, Institute Biomaterials and Biomedical Engineering, University of Toronto, 144 College Street, Toronto, Ontario, Canada
J Control Release 138:214-23. 2009
..This review aims to highlight these and other important advancements as well as to bring attention to the many critical questions that remain to be addressed regarding the fate of BCM-based drug formulations in vivo...
- Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy
Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
Bioconjug Chem 16:122-30. 2005
- Environmental and health hazard ranking and assessment of plastic polymers based on chemical composition
Department of Plant and Environmental Sciences, University of Gothenburg, P O Box 461, 405 30 Goteborg, Sweden
Sci Total Environ 409:3309-24. 2011
..Most chemicals used for producing plastic polymers are derived from non-renewable crude oil, and several are hazardous...
- Structure and assembly of Gram-positive bacterial pili: unique covalent polymers
Hae Joo Kang
School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
Curr Opin Struct Biol 22:200-7. 2012
..recently characterised pili expressed by Gram-positive pathogens represent a novel variation; completely covalent polymers in which sortase-mediated isopeptide bonds link successive pilin subunits...
- Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
Centre de Biophysique Moléculaire CNRS UPR 4301 affiliated to the University of Orléans and Inserm, rue Charles Sadron, F 45071 Orleans cedex 2, France
Br J Pharmacol 157:166-78. 2009
..Here, we present a current report on a particular class of carriers including the polymers, peptides and lipids, which is based on the exploitation of the imidazole ring as an endosome destabilization ..
- Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates
Anand S Badami
Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0211, USA
Biomaterials 27:596-606. 2006
..These studies show that topographical factors designed into biomaterial scaffolds can regulate spreading, orientation, and proliferation of osteoblastic cells...
- Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer
K J Brodbeck
Department of Chemical Engineering, University of Illinois, Urbana 61801, USA
J Control Release 62:333-44. 1999
..An interpretation of these results in terms of a qualitative model for the protein release mechanism is also given...
- Polymeric growth factor delivery strategies for tissue engineering
Ruth R Chen
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
Pharm Res 20:1103-12. 2003
..The purpose of this review is to present the application of polymeric delivery systems for growth factor delivery in tissue engineering...
- Sterilizable gels from thermoresponsive block copolymer worms
Department of Chemistry, The University of Sheffield, Dainton Building, Brook Hill, Sheffield S3 7HF, UK
J Am Chem Soc 134:9741-8. 2012
..Biocompatibility tests indicate good cell viabilities for these worm gels, which suggest potential biomedical applications...
- Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review
Polymer Section, Chemical Science Division, Regional Research Laboratory CSIR, Trivandrum 695 019, India
J Control Release 114:1-14. 2006
..sensitive hydrogels like alginate and chitosan have attracted increasing attention, since most of the synthetic polymers are immunogenic and the incorporation of proteins in to these polymers require harsh environment which may ..
- Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export
Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
Structure 20:1007-18. 2012
- Removal of arsenic from contaminated water sources by sorption onto iron-oxide-coated polymeric materials
Ioannis A Katsoyiannis
Aristotle University of Thessaloniki, Department of Chemistry, Greece
Water Res 36:5141-55. 2002
..Though, among the examined materials, polyHIPE was found to be more effective in the removal of arsenic, as far as it concerns the maximum sorptive capacity before the filtration bed reaches the respective breakthrough point...
- Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility
Patrick J Marsac
Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
Pharm Res 23:2417-26. 2006
..thermodynamic approaches, both practical and theoretical, that will yield a better understanding of which factors are most important for determining the ability of polymers to stabilize amorphous active pharmaceutical ingredients (API).
- Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment
State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Biomaterials 25:4777-83. 2004
..The results showed that improved cell adhesion was attributed to the combination of surface chemistry and surface morphology of PLGA during plasma etching...
- Self-assembly of block copolymers
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada
Chem Soc Rev 41:5969-85. 2012
..As one specific example at a more advanced level, BCP vesicles (polymersomes) and their potential applications are discussed in some detail...
- Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies
Tae You Kim
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
Clin Cancer Res 10:3708-16. 2004
..A phase I study was performed to determine the maximum tolerated dosage, dose-limiting toxicities, and the pharmacokinetic profile of Genexol-PM in patients with advanced, refractory malignancies...
- Photoswitchable gel assembly based on molecular recognition
Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
Nat Commun 3:603. 2012
..The differential affinities of α-cyclodextrin or β-cyclodextrin for the trans-azobenzene and cis-azobenzene are employed in the construction of a photoswitchable gel assembly system...