Summary: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).

Articles from Journal RESEARCH

Top Publications

  1. ncbi Design and development of polymers for gene delivery
    Daniel W Pack
    Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Nat Rev Drug Discov 4:581-93. 2005
  2. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
  3. ncbi Toxicity of cationic lipids and cationic polymers in gene delivery
    Hongtao Lv
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China
    J Control Release 114:100-9. 2006
  4. ncbi Synthetic biodegradable polymers as orthopedic devices
    J C Middleton
    Birmingham Polymers, Inc, AL 35211, USA
    Biomaterials 21:2335-46. 2000
  5. pmc Polymers for drug delivery systems
    William B Liechty
    Department of Chemical Engineering, University of Texas, Austin, TX 78712 1062, USA
    Annu Rev Chem Biomol Eng 1:149-73. 2010
  6. pmc Synthetic genetic polymers capable of heredity and evolution
    Vitor B Pinheiro
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Science 336:341-4. 2012
  7. ncbi Long-circulating and target-specific nanoparticles: theory to practice
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
    Pharmacol Rev 53:283-318. 2001
  8. ncbi Polymer vesicles
    Dennis E Discher
    School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104 6393, USA
    Science 297:967-73. 2002
  9. ncbi Block copolymer micelles for drug delivery: design, characterization and biological significance
    K Kataoka
    Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Adv Drug Deliv Rev 47:113-31. 2001
  10. ncbi Biodegradable, elastic shape-memory polymers for potential biomedical applications
    Andreas Lendlein
    mnemoScience GmbH, Pauwelsstrabetae 19, D 52074 Aachen, Germany
    Science 296:1673-6. 2002

Detail Information

Articles from Journal RESEARCH1

Publications416 found, 100 shown here

  1. ncbi Design and development of polymers for gene delivery
    Daniel W Pack
    Department of Chemical and Biomolecular Engineering, University of Illinois, Box C 3, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Nat Rev Drug Discov 4:581-93. 2005
    ..In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function ..
  2. ncbi Porosity of 3D biomaterial scaffolds and osteogenesis
    Vassilis Karageorgiou
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 26:5474-91. 2005
    ..New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs...
  3. ncbi Toxicity of cationic lipids and cationic polymers in gene delivery
    Hongtao Lv
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China
    J Control Release 114:100-9. 2006
    ..Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy to produce ..
  4. ncbi Synthetic biodegradable polymers as orthopedic devices
    J C Middleton
    Birmingham Polymers, Inc, AL 35211, USA
    Biomaterials 21:2335-46. 2000
    ..In this article we will focus on properties of biodegradable polymers which make them ideally suited for orthopedic applications where a permanent implant is not desired...
  5. pmc Polymers for drug delivery systems
    William B Liechty
    Department of Chemical Engineering, University of Texas, Austin, TX 78712 1062, USA
    Annu Rev Chem Biomol Eng 1:149-73. 2010
    b>Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and ..
  6. pmc Synthetic genetic polymers capable of heredity and evolution
    Vitor B Pinheiro
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Science 336:341-4. 2012
    Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental functional constraints is currently unknown...
  7. ncbi Long-circulating and target-specific nanoparticles: theory to practice
    S M Moghimi
    Molecular Targeting and Polymer Toxicology Group, School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, United Kingdom
    Pharmacol Rev 53:283-318. 2001
    ..With regard to the targeting issues, attention is particularly focused on the importance of physiological barriers and disease states...
  8. ncbi Polymer vesicles
    Dennis E Discher
    School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104 6393, USA
    Science 297:967-73. 2002
    ..including stability, fluidity, and intermembrane dynamics, are greatly influenced by characteristics of the polymers. Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but ..
  9. ncbi Block copolymer micelles for drug delivery: design, characterization and biological significance
    K Kataoka
    Department of Materials Science, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Adv Drug Deliv Rev 47:113-31. 2001
    ..As an important perspective on carrier systems based on polymeric micelles, their feasibility as non-viral gene vectors is also summarized in this review article...
  10. ncbi Biodegradable, elastic shape-memory polymers for potential biomedical applications
    Andreas Lendlein
    mnemoScience GmbH, Pauwelsstrabetae 19, D 52074 Aachen, Germany
    Science 296:1673-6. 2002
    ..This report describes a group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature...
  11. doi Bioreducible polymers for gene silencing and delivery
    Sejin Son
    Department of Chemistry, Pohang University of Science and Technology, Korea
    Acc Chem Res 45:1100-12. 2012
    ..Among the numerous multifunctional polymers that have been designed and evaluated as gene delivery vectors, polymers with redox-sensitive (or bioreducible) ..
  12. ncbi Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
    Norased Nasongkla
    Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Nano Lett 6:2427-30. 2006
    ..In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles...
  13. pmc Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction
    Oliver Gordon
    Infection Biology, Department of Biomedicine, University Hospital, CH 4056 Basel, Switzerland
    Antimicrob Agents Chemother 54:4208-18. 2010
    ..This is the first report investigating the global metabolic effects of silver in the context of a therapeutic application. We anticipate that the compounds presented here open a new treatment field with a high medical impact...
  14. pmc Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety
    Pedro M M Mesquita
    Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Infect Dis 200:599-608. 2009
    ..The lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present experiments were designed to evaluate the predictive value of in vitro models of microbicide safety...
  15. ncbi Lipid bilayer disruption by polycationic polymers: the roles of size and chemical functional group
    Almut Mecke
    Department of Physics, University of Michigan, Ann Arbor, 48109, USA
    Langmuir 21:10348-54. 2005
    Polycationic polymers are used extensively in biology to disrupt cell membranes and thus enhance the transport of materials into the cell...
  16. pmc Functional supramolecular polymers
    T Aida
    Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Tokyo, Japan
    Science 335:813-7. 2012
    Supramolecular polymers can be random and entangled coils with the mechanical properties of plastics and elastomers, but with great capacity for processability, recycling, and self-healing due to their reversible monomer-to-polymer ..
  17. ncbi The chemistry and applications of antimicrobial polymers: a state-of-the-art review
    El Refaie Kenawy
    Department of Chemistry, Polymer Research Group, Faculty of Science, University of Tanta, Tanta 31527, Egypt
    Biomacromolecules 8:1359-84. 2007
    ..The use of antimicrobial polymers offers promise for enhancing the efficacy of some existing antimicrobial agents and minimizing the environmental ..
  18. doi Cationic polymers and their therapeutic potential
    Sangram Keshari Samal
    Polymer Chemistry and Biomaterials Research Group, Ghent University, Krijgslaan 281, S4 bis, B 9000 Ghent, Belgium
    Chem Soc Rev 41:7147-94. 2012
    The last decade has witnessed enormous research focused on cationic polymers. Cationic polymers are the subject of intense research as non-viral gene delivery systems, due to their flexible properties, facile synthesis, robustness and ..
  19. ncbi Microtubule polymerization dynamics
    A Desai
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143, USA
    Annu Rev Cell Dev Biol 13:83-117. 1997
    ..In this review, we first describe progress toward understanding the mechanism of dynamic instability of pure tubulin and then discuss the function and regulation of microtubule dynamic instability in living cells...
  20. doi Stimuli-responsive polymers and nanomaterials for gene delivery and imaging applications
    Min Suk Shim
    Department of Chemical Engineering and Materials Science, University of California, Irvine, 92697, USA
    Adv Drug Deliv Rev 64:1046-59. 2012
  21. pmc PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
    Sheena McCormack
    MRC Clinical Trials Unit, London, UK
    Lancet 376:1329-37. 2010
    ..PRO2000 vaginal gel was efficacious against HIV-1 transmission in studies in macaques; we aimed to assess efficacy and safety of 2% and 0·5% PRO2000 gels against vaginal HIV-1 transmission in women in sub-Saharan Africa...
  22. ncbi Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
    Catherine M Cowan
    The Department of Surgery, Stanford University School of Medicine, Stanford University, 257 Campus Drive, Stanford, California 94305, USA
    Nat Biotechnol 22:560-7. 2004
    ..The contribution of implanted cells to new bone formation was 84-99% by chromosomal detection. These data show that ADAS cells heal critical-size skeletal defects without genetic manipulation or the addition of exogenous growth factors...
  23. pmc Gold nanocages covered by smart polymers for controlled release with near-infrared light
    Mustafa S Yavuz
    Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130, USA
    Nat Mater 8:935-9. 2009
    ..This system works well with various effectors without involving sophisticated syntheses, and is well suited for in vivo studies owing to the high transparency of soft tissue in the near-infrared region...
  24. pmc Catechol polymers for pH-responsive, targeted drug delivery to cancer cells
    Jing Su
    Biomedical Engineering Department, Northwestern University, Evanston, Illinois 60208, USA
    J Am Chem Soc 133:11850-3. 2011
  25. doi Silk-elastinlike protein polymers for matrix-mediated cancer gene therapy
    Joshua A Gustafson
    Department of Bioengineering, University of Utah, Salt Lake City, USA
    Adv Drug Deliv Rev 62:1509-23. 2010
    Silk-elastinlike protein polymers (SELPs) are recombinant polymers designed from silk fibroin and mammalian elastin amino acid repeats...
  26. ncbi Tuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives
    M Firat Ilker
    Department of Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    J Am Chem Soc 126:15870-5. 2004
    ..hemolytic activity against human red blood cells were measured and compared to determine the selectivity of the polymers for bacterial over mammalian cells...
  27. ncbi Synergistic activity of hydrophilic modification in antibiotic polymers
    Philippe H Sellenet
    Department of Materials Engineering, Purdue University, West Lafayette, Indiana 47907, USA
    Biomacromolecules 8:19-23. 2007
    ..A hydrophilicity based design-paradigm can significantly improve both the efficacy and the biocompatibility of antibacterial materials...
  28. ncbi Dynamics of membrane protein/amphipol association studied by Förster resonance energy transfer: implications for in vitro studies of amphipol-stabilized membrane proteins
    Manuela Zoonens
    Laboratoire de Physico Chimie Moléculaire des Membranes Biologiques, UMR 7099, Centre National de la Recherche Scientifique, and Institut de Biologie Physico Chimique, Universite Paris 7, 13 rue Pierre et Marie Curie, F 75005 Paris, France
    Biochemistry 46:10392-404. 2007
    Amphipols (APols) are short amphipathic polymers that can substitute for detergents to keep membrane proteins (MPs) water-soluble while stabilizing them biochemically...
  29. doi Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect
    H Maeda
    Laboratory of Microbiology and Oncology, Sojo University, Kumamoto, Japan
    Eur J Pharm Biopharm 71:409-19. 2009
  30. doi Mucoadhesive polymeric platforms for controlled drug delivery
    Gavin P Andrews
    School of Pharmacy, The Queen s University of Belfast, Belfast, Ireland
    Eur J Pharm Biopharm 71:505-18. 2009
    ..Evolution of such mucoadhesive formulations has transgressed from first-generation charged hydrophilic polymer networks to more specific second-generation systems based on lectin, thiol and various other adhesive functional groups...
  31. pmc Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    Jianjun Cheng
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biomaterials 28:869-76. 2007
    ..22%+/-0.07% of injected dose per gram of tissue; mean+/-SD, n=4, p=0.002). The ability to control NP size together with targeted delivery may result in favorable biodistribution and development of clinically relevant targeted therapies...
  32. pmc Entropy-driven spatial organization of highly confined polymers: lessons for the bacterial chromosome
    Suckjoon Jun
    Stichting voor Fundamenteel Onderzoek der Materie FOM Institute for Atomic and Molecular Physics AMOLF, Kruislaan 407, 1098 SJ, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:12388-93. 2006
    ..with bacterial chromosome segregation, namely the spatial organization of highly confined, self-avoiding polymers (of nontrivial topology) in a rod-shaped cell-like geometry...
  33. ncbi Amphiphilic block copolymers for drug delivery
    Monica L Adams
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53705 2222, USA
    J Pharm Sci 92:1343-55. 2003
    ..The purpose of this minireview is to provide a concise, yet detailed, introduction to the use of ABCs and polymeric micelles as delivery agents as well as to highlight current and past work in this area...
  34. ncbi Biodegradable polymers for the environment
    Richard A Gross
    Polytechnic University, National Science Foundation Center for Biocatalysis and Bioprocessing of Macromolecules, Six Metrotech Center, Brooklyn, NY 11201, USA
    Science 297:803-7. 2002
    Biodegradable polymers are designed to degrade upon disposal by the action of living organisms...
  35. doi Microbial production of building block chemicals and polymers
    Jeong Wook Lee
    Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering BK21 Program, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, 291 Daehak ro, Yuseong Gu, Daejeon 305 701, Republic of Korea
    Curr Opin Biotechnol 22:758-67. 2011
    ..b>Polymers we use everyday can also be produced either by direct fermentation or by polymerization of monomers that are ..
  36. doi Polyhydroxyalkanoates as a source of chemicals, polymers, and biofuels
    Xue Gao
    Protein Science Laboratory of the Ministry of Education, Dept of Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Curr Opin Biotechnol 22:768-74. 2011
    ..putida makes it possible to achieve precise substrate based design of PHA homopolymers, copolymers, and block polymers, allowing the study of structure-property relationship in a clear way...
  37. ncbi Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    C E Kast
    Institute of Pharmaceutical Technology and Biopharmaceutics, Center of Pharmacy, University of Vienna, Austria
    Biomaterials 22:2345-52. 2001
    ..on the pH-value and the weight ratio of polymer to TGA during the coupling reaction the resulting thiolated polymers, the so-called thiomers, displayed 6.58, 9.88, 27.44, and 38.23 micromole thiol groups per gram polymer...
  38. ncbi Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
    Si Shen Feng
    Division of Bioengineering, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260
    Curr Med Chem 11:413-24. 2004
    ..Nanoparticles of biodegradable polymers can provide an ideal solution to such an adjuvant problem and realize a controlled and targeted delivery of the ..
  39. doi A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency
    Elena Miranda
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Cambridge, UK
    Hepatology 52:1078-88. 2010
    ..severe Z deficiency allele (Glu342Lys) causes the protein to undergo a conformational transition and form ordered polymers that are retained within hepatocytes. This causes neonatal hepatitis, cirrhosis, and hepatocellular carcinoma...
  40. ncbi Chitosan-graft-polyethylenimine as a gene carrier
    Hu Lin Jiang
    School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea
    J Control Release 117:273-80. 2007
    Chitosans have been proposed as biocompatible alternative cationic polymers that are suitable for non-viral delivery. However, the transfection efficiency of chitosan-DNA nanoparticles is still very low...
  41. ncbi The dawning era of polymer therapeutics
    Ruth Duncan
    Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK
    Nat Rev Drug Discov 2:347-60. 2003
  42. ncbi Self-assembly at all scales
    George M Whitesides
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 295:2418-21. 2002
    ..The concept of self-assembly is used increasingly in many disciplines, with a different flavor and emphasis in each...
  43. ncbi Polymer conjugates as anticancer nanomedicines
    Ruth Duncan
    Centre for Polymer Therapeutics, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3XF, UK
    Nat Rev Cancer 6:688-701. 2006
    ..There is growing optimism that ever more sophisticated polymer-based vectors will be a significant addition to the armoury currently used for cancer therapy...
  44. pmc Photodegradable hydrogels for dynamic tuning of physical and chemical properties
    April M Kloxin
    Department of Chemical and Biological Engineering, University of Colorado, 424 UCB ECCH 111, Boulder, CO 80309, USA
    Science 324:59-63. 2009
  45. doi Soft porous crystals
    Satoshi Horike
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto 615 8510, Japan
    Nat Chem 1:695-704. 2009
    ..Recent developments on porous coordination polymers (or metal-organic frameworks) have provided the inherent properties that combine these features...
  46. ncbi Polymer-supported membranes as models of the cell surface
    Motomu Tanaka
    Department of Physics, Technical University of Munich, D 85748 Garching, Germany
    Nature 437:656-63. 2005
    ..Particularly exciting opportunities arise when these systems are coupled with advanced semiconductor technology...
  47. pmc Polymers in small-interfering RNA delivery
    Kaushik Singha
    Department of Chemistry, BK School of Molecular Science, Polymer Research Institute, Pohang University of Science and Technology, Pohang, Korea
    Nucleic Acid Ther 21:133-47. 2011
    ..that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic-co-glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and ..
  48. ncbi Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability
    Seungpyo Hong
    Program in Applied Physics, Department of Chemistry, and Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
    Bioconjug Chem 17:728-34. 2006
    Interactions of polycationic polymers with supported 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers and live cell membranes (KB and Rat2) have been investigated using atomic force microscopy (AFM), cytosolic enzyme ..
  49. doi Folate-functionalized polymeric micelle as hepatic carcinoma-targeted, MRI-ultrasensitive delivery system of antitumor drugs
    Guobin Hong
    Department of Radiology, The Second Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Biomed Microdevices 10:693-700. 2008
  50. doi Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer for coronary revascularisation (LEADERS): a randomised non-inferiority trial
    Stephan Windecker
    Department of Cardiology, and CTU Bern, Bern University Hospital, Bern, Switzerland
    Lancet 372:1163-73. 2008
    ..We compared the safety and efficacy of a biolimus-eluting stent (with biodegradable polymer) with a sirolimus-eluting stent (with durable polymer)...
  51. pmc Antibacterial studies of cationic polymers with alternating, random, and uniform backbones
    Airong Song
    Department of Chemistry, Stony Brook University, Stony Brook, NY 11794 3400, United States
    ACS Chem Biol 6:590-9. 2011
    Antibacterial polymers have potential as pharmaceuticals and as coatings for implantation devices...
  52. doi Dramatic tuning of carbon dioxide uptake via metal substitution in a coordination polymer with cylindrical pores
    Stephen R Caskey
    Department of Chemistry and Macromolecular Science and Engineering Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan, 48109 1055, USA
    J Am Chem Soc 130:10870-1. 2008
    A series of four isostructural microporous coordination polymers (MCPs) differing in metal composition is demonstrated to exhibit exceptional uptake of CO2 at low pressures and ambient temperature...
  53. pmc Functional metagenomics unveils a multifunctional glycosyl hydrolase from the family 43 catalysing the breakdown of plant polymers in the calf rumen
    Manuel Ferrer
    CSIC, Institute of Catalysis, Madrid, Spain
    PLoS ONE 7:e38134. 2012
    Microbial communities from cow rumen are known for their ability to degrade diverse plant polymers at high rates...
  54. pmc The use of amphipols as universal molecular adapters to immobilize membrane proteins onto solid supports
    Delphine Charvolin
    Unite Mixte de Recherche 7099, Centre National de la Recherche Scientifique and Université Paris 7, Institut de Biologie Physico Chimique, Centre National de la Recherche Scientifique, Federated Research Institute 550, Paris, France
    Proc Natl Acad Sci U S A 106:405-10. 2009
    ..for immobilizing functional, unmodified integral membrane proteins onto solid supports, thanks to amphipathic polymers called "amphipols...
  55. ncbi Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering
    F Yang
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    Biomaterials 26:2603-10. 2005
    ..Based on the experimental results, the aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering...
  56. pmc Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach
    Karen Lienkamp
    Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Am Chem Soc 130:9836-43. 2008
    ..Using amphiphilicity, monomer feed ratio, and molecular weight as parameters, polymers with 533 times higher selectivitiy (selecitviy = hemolytic concentration/minimum inhibitory concentration) for ..
  57. pmc Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry
    Takuya Matsumura
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Gastroenterology 137:673-81. 2009
    ..Hepatitis C virus (HCV) gains entry into susceptible cells by interacting with cell surface receptor(s). Viral entry is an attractive target for antiviral development because of the highly conserved mechanism...
  58. doi In vitro biocompatibility studies of antibacterial quaternary polymers
    Thomas R Stratton
    School of Materials Engineering, Purdue University, 701 West Stadium Avenue, West Lafayette, Indiana 47907 2044, USA
    Biomacromolecules 10:2550-5. 2009
    ..We have shown that these copolymers are biocompatible at concentrations above their minimum bactericidal concentrations, leading to selectivity values that compare well with other microbicidal products...
  59. pmc Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency
    Adriana Ordonez
    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, UK
    Hepatology 57:2049-60. 2013
    Point mutants of alpha1 -antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma...
  60. pmc De novo design of antimicrobial polymers, foldamers, and small molecules: from discovery to practical applications
    Gregory N Tew
    Department of Chemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6059, USA
    Acc Chem Res 43:30-9. 2010
    ..Finally, we apply the principles discovered through this work to the design of inexpensive antimicrobial polymers and materials.
  61. ncbi Mutant Neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro
    Didier Belorgey
    Respiratory Medicine Unit and Neurology Unit, Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, United Kingdom
    J Biol Chem 277:17367-73. 2002
    ..9 and 56.6 degrees C, respectively) and more readily formed loop-sheet polymers under physiological conditions...
  62. ncbi Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Jayanth Panyam
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Adv Drug Deliv Rev 55:329-47. 2003
    ..Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed...
  63. doi Polymers for siRNA delivery: inspired by viruses to be targeted, dynamic, and precise
    Ernst Wagner
    Pharmaceutical Biotechnology, Center for System based Drug Research, Ludwig Maximilians Universitat Munchen, Germany
    Acc Chem Res 45:1005-13. 2012
    ..For example, cationic polymers can reversibly package one or more siRNA molecules into nanoparticle cores to protect them against a degradative ..
  64. doi Improved safety and reduction in stent thrombosis associated with biodegradable polymer-based biolimus-eluting stents versus durable polymer-based sirolimus-eluting stents in patients with coronary artery disease: final 5-year report of the LEADERS (Limus
    Patrick W Serruys
    Thoraxcenter, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands
    JACC Cardiovasc Interv 6:777-89. 2013
    ..This study sought to report the final 5 years follow-up of the landmark LEADERS (Limus Eluted From A Durable Versus ERodable Stent Coating) trial...
  65. pmc In vitro toxicity assessment of amphiphillic polymer-coated CdSe/ZnS quantum dots in two human liver cell models
    Wesley E Smith
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, United States
    ACS Nano 6:9475-84. 2012
    ..Thus, further in vivo studies are warranted to ensure that TOPO-PMAT-coated Qdots used in biomedical applications do not induce inflammatory responses as a consequence of hepatic uptake...
  66. ncbi Polymers for gene delivery: current status and future perspectives
    M R Rekha
    Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
    Recent Pat DNA Gene Seq 6:98-107. 2012
    ..Hence there is a need for developing non-viral vectors which can really be used for clinical applications. Polymers are a versatile group of molecules which can be modified and designed or engineered according to the end needs of ..
  67. doi Ocular drug delivery system: a reference to natural polymers
    Priyanka Pahuja
    Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India
    Expert Opin Drug Deliv 9:837-61. 2012
    ..The natural polymers have represented the potential to deliver drugs topically through the limited precorneal area and release over a ..
  68. pmc Combinatorial discovery of polymers resistant to bacterial attachment
    Andrew L Hook
    Laboratory of Biophysics and Surface Analysis, University of Nottingham, Nottingham, UK
    Nat Biotechnol 30:868-75. 2012
    ..These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have ..
  69. doi Nanoporous polymers for hydrogen storage
    Jonathan Germain
    University of California Berkeley, 94720 1460, USA
    Small 5:1098-111. 2009
    ..In this work, progress towards hydrogen storage with nanoporous materials in general and porous organic polymers in particular is critically reviewed...
  70. ncbi Biologically responsive polymeric nanoparticles for drug delivery
    Yolonda L Colson
    Division of Thoracic Surgery, Department of Surgery, Brigham and Women s Hospital, Boston MA 02215, USA
    Adv Mater 24:3878-86. 2012
  71. pmc Variant-specific [PSI+] infection is transmitted by Sup35 polymers within [PSI+] aggregates with heterogeneous protein composition
    Sviatoslav N Bagriantsev
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA
    Mol Biol Cell 19:2433-43. 2008
    ..exist in different heritable conformations, called "variants," and they are composed of detergent-resistant Sup35 polymers, which may be closely associated with themselves, other proteins, or both...
  72. ncbi "Bite-and-Switch" approach using computationally designed molecularly imprinted polymers for sensing of creatinine
    S Subrahmanyam
    Institute of BioScience and Technology, Cranfield University at Silsoe, Bedfordshire MK45 4DT, UK
    Biosens Bioelectron 16:631-7. 2001
    ..has been demonstrated previously for the detection of creatine using creatine-imprinted molecularly imprinted polymers (MIPs) Since MIPs created using traditional methods were unable to differentiate between creatine and creatinine, ..
  73. pmc A combinatorial polymer library approach yields insight into nonviral gene delivery
    Jordan J Green
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Acc Chem Res 41:749-59. 2008
    ..This Account describes an alternative strategy to viral gene delivery: the design of biodegradable polymers that are able to deliver DNA like a synthetic virus...
  74. doi Electrochemical sensor for dopamine based on a novel graphene-molecular imprinted polymers composite recognition element
    Yan Mao
    Engineering Laboratory for Modern Analytical Techniques, c o State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, Jilin, PR China
    Biosens Bioelectron 28:291-7. 2011
    A novel composite of graphene sheets/Congo red-molecular imprinted polymers (GSCR-MIPs) was synthesized through free radical polymerization (FRP) and applied as a molecular recognition element to construct dopamine (DA) electrochemical ..
  75. ncbi Technological and biological evaluation of tablets containing different strains of lactobacilli for vaginal administration
    L Maggi
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    Eur J Pharm Biopharm 50:389-95. 2000
    ..Three different retarding polymers were tested, and all the formulations and tablets were evaluated in terms of technological processability, ..
  76. doi Structure and disassembly of filaments formed by the ESCRT-III subunit Vps24
    Sara Ghazi-Tabatabai
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Structure 16:1345-56. 2008
    ..Among the core yeast ESCRT-III subunits, Snf7 and Vps24 spontaneously form ordered polymers in vitro...
  77. ncbi Prospects for cationic polymers in gene and oligonucleotide therapy against cancer
    Thomas Merdan
    Department of Pharmaceutics and Biopharmacy, Philipps University, Ketzerbach 63, 35032 Marburg, Germany
    Adv Drug Deliv Rev 54:715-58. 2002
    ..This review will introduce the most important cationic polymers used as non-viral vectors for gene and oligonucleotide delivery and will summarize strategies for the targeting ..
  78. doi Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    Islamic Azad University, Najafabad Branch, Isfahan, Iran
    J Tissue Eng Regen Med 5:e17-35. 2011
    ..shown to enhance the nerve regeneration process and this consequently makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering...
  79. ncbi Polymers of intrinsic microporosity (PIMs): organic materials for membrane separations, heterogeneous catalysis and hydrogen storage
    Neil B McKeown
    School of Chemistry, Cardiff University, Cardiff, CF10 3AT, UK
    Chem Soc Rev 35:675-83. 2006
    ..describes recent research directed towards the synthesis of polymer-based organic microporous materials termed Polymers of Intrinsic Microporosity (PIMs)...
  80. doi Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
    Qing Xu
    CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, China
    Biomaterials 33:1627-39. 2012
    ..Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy.
  81. doi Recent advances in the development of semiconducting DPP-containing polymers for transistor applications
    Christian B Nielsen
    Department of Chemistry and Centre for Plastic Electronics, Imperial College London, London SW7 2AZ, United Kingdom
    Adv Mater 25:1859-80. 2013
    This progress report summarizes the numerous DPP-containing polymers recently developed for field-effect transistor applications including diphenyl-DPP and dithienyl-DPP-based polymers as the most commonly reported materials, but also ..
  82. doi Mechanisms underlying molecularly imprinted polymer molecular memory and the role of crosslinker: resolving debate on the nature of template recognition in phenylalanine anilide imprinted polymers
    Gustaf D Olsson
    Bioorganic and Biophysical Chemistry Laboratory, School of Natural Sciences, Linnaeus University, SE 391 82 Kalmar, Sweden
    J Mol Recognit 25:69-73. 2012
    ..for phenylalanine anilide imprinted co-(ethylene glycol dimethacrylate-methacrylic acid) molecularly imprinted polymers have been employed to investigate the mechanistic basis for template selective recognition in these systems...
  83. doi Zwitterionic polymer-based platform with two-layer architecture for ultra low fouling and high protein loading
    Chun Jen Huang
    Department of Chemical Engineering, University of Washington, Seattle, Washington 98195 1750, USA
    Anal Chem 84:3440-5. 2012
    ..disulfide (TED) and water in the reaction were varied to regulate the packing density and chain length of polymers, respectively, for the second pCB layer...
  84. doi Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers
    Tsutomu Ishihara
    Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
    Biomacromolecules 11:2700-6. 2010
    ..this study, we evaluated the induction of the ABC phenomenon using nanoparticles coated with various hydrophilic polymers instead of PEG...
  85. doi Block copolymer micelles for delivery of cancer therapy: transport at the whole body, tissue and cellular levels
    Andrew S Mikhail
    Leslie Dan Faculty of Pharmacy, Institute Biomaterials and Biomedical Engineering, University of Toronto, 144 College Street, Toronto, Ontario, Canada
    J Control Release 138:214-23. 2009
    ..This review aims to highlight these and other important advancements as well as to bring attention to the many critical questions that remain to be addressed regarding the fate of BCM-based drug formulations in vivo...
  86. ncbi Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy
    Younsoo Bae
    Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Bioconjug Chem 16:122-30. 2005
  87. doi Environmental and health hazard ranking and assessment of plastic polymers based on chemical composition
    Delilah Lithner
    Department of Plant and Environmental Sciences, University of Gothenburg, P O Box 461, 405 30 Goteborg, Sweden
    Sci Total Environ 409:3309-24. 2011
    ..Most chemicals used for producing plastic polymers are derived from non-renewable crude oil, and several are hazardous...
  88. doi Structure and assembly of Gram-positive bacterial pili: unique covalent polymers
    Hae Joo Kang
    School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Curr Opin Struct Biol 22:200-7. 2012
    ..recently characterised pili expressed by Gram-positive pathogens represent a novel variation; completely covalent polymers in which sortase-mediated isopeptide bonds link successive pilin subunits...
  89. pmc Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
    Patrick Midoux
    Centre de Biophysique Moléculaire CNRS UPR 4301 affiliated to the University of Orléans and Inserm, rue Charles Sadron, F 45071 Orleans cedex 2, France
    Br J Pharmacol 157:166-78. 2009
    ..Here, we present a current report on a particular class of carriers including the polymers, peptides and lipids, which is based on the exploitation of the imidazole ring as an endosome destabilization ..
  90. ncbi Effect of fiber diameter on spreading, proliferation, and differentiation of osteoblastic cells on electrospun poly(lactic acid) substrates
    Anand S Badami
    Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061 0211, USA
    Biomaterials 27:596-606. 2006
    ..These studies show that topographical factors designed into biomaterial scaffolds can regulate spreading, orientation, and proliferation of osteoblastic cells...
  91. ncbi Phase inversion dynamics of PLGA solutions related to drug delivery. Part II. The role of solution thermodynamics and bath-side mass transfer
    K J Brodbeck
    Department of Chemical Engineering, University of Illinois, Urbana 61801, USA
    J Control Release 62:333-44. 1999
    ..An interpretation of these results in terms of a qualitative model for the protein release mechanism is also given...
  92. ncbi Polymeric growth factor delivery strategies for tissue engineering
    Ruth R Chen
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA
    Pharm Res 20:1103-12. 2003
    ..The purpose of this review is to present the application of polymeric delivery systems for growth factor delivery in tissue engineering...
  93. doi Sterilizable gels from thermoresponsive block copolymer worms
    Adam Blanazs
    Department of Chemistry, The University of Sheffield, Dainton Building, Brook Hill, Sheffield S3 7HF, UK
    J Am Chem Soc 134:9741-8. 2012
    ..Biocompatibility tests indicate good cell viabilities for these worm gels, which suggest potential biomedical applications...
  94. ncbi Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review
    Meera George
    Polymer Section, Chemical Science Division, Regional Research Laboratory CSIR, Trivandrum 695 019, India
    J Control Release 114:1-14. 2006
    ..sensitive hydrogels like alginate and chitosan have attracted increasing attention, since most of the synthetic polymers are immunogenic and the incorporation of proteins in to these polymers require harsh environment which may ..
  95. pmc Structural basis for polyadenosine-RNA binding by Nab2 Zn fingers and its function in mRNA nuclear export
    Christoph Brockmann
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Structure 20:1007-18. 2012
  96. ncbi Removal of arsenic from contaminated water sources by sorption onto iron-oxide-coated polymeric materials
    Ioannis A Katsoyiannis
    Aristotle University of Thessaloniki, Department of Chemistry, Greece
    Water Res 36:5141-55. 2002
    ..Though, among the examined materials, polyHIPE was found to be more effective in the removal of arsenic, as far as it concerns the maximum sorptive capacity before the filtration bed reaches the respective breakthrough point...
  97. ncbi Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility
    Patrick J Marsac
    Department of Industrial and Physical Pharmacy, School of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA
    Pharm Res 23:2417-26. 2006
    ..thermodynamic approaches, both practical and theoretical, that will yield a better understanding of which factors are most important for determining the ability of polymers to stabilize amorphous active pharmaceutical ingredients (API).
  98. ncbi Characterization of surface property of poly(lactide-co-glycolide) after oxygen plasma treatment
    Yuqing Wan
    State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
    Biomaterials 25:4777-83. 2004
    ..The results showed that improved cell adhesion was attributed to the combination of surface chemistry and surface morphology of PLGA during plasma etching...
  99. doi Self-assembly of block copolymers
    Yiyong Mai
    Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada
    Chem Soc Rev 41:5969-85. 2012
    ..As one specific example at a more advanced level, BCP vesicles (polymersomes) and their potential applications are discussed in some detail...
  100. ncbi Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies
    Tae You Kim
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
    Clin Cancer Res 10:3708-16. 2004
    ..A phase I study was performed to determine the maximum tolerated dosage, dose-limiting toxicities, and the pharmacokinetic profile of Genexol-PM in patients with advanced, refractory malignancies...
  101. pmc Photoswitchable gel assembly based on molecular recognition
    Hiroyasu Yamaguchi
    Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Nat Commun 3:603. 2012
    ..The differential affinities of α-cyclodextrin or β-cyclodextrin for the trans-azobenzene and cis-azobenzene are employed in the construction of a photoswitchable gel assembly system...

Research Grants75

  1. HK polymers as transfection reagents for siRNA delivery
    Frank Xie; Fiscal Year: 2005
    ..We have developed a group of HK polymers and utilized them as nucleic acid carrier for in vitro and in vivo delivery...
  2. Gene Delivery of P53 in a Tumor-bearing Mouse Model
    ARCHIBALD MIXSON; Fiscal Year: 2007
    ..Recently our laboratory has developed linear and branched HK (histidine-lysine) polymers that in combination with liposomes significantly increased transfection in the presence or absence of serum...
  3. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..therefore, are to (i) develop an exchangeable valve that can be fitted with leaflets composed biodegradable polymers typically used for tissue engineering, and (ii) evaluate the integrity of the tissue ingrowth into the ..
  4. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..We also will add peptides that will target the nanoparticles to specific cells within the bladder. These siRNA polymers will be instilled into the bladder as a treatment for urological diseases...
    Sung Wan Kim; Fiscal Year: 2012
    ..Non-viral polymers possess several characteristics that are favorable for use in cellular therapy of ischemic myocardium...
  6. Hepatocarcinogenesis Secondary to Hepatitis C
    Srikanta Dash; Fiscal Year: 2012
    ..We propose that encapsulation of siRNA-74 into nanoparticles by the use of biodegradable polymers will efficiently deliver siRNA to the hepatocytes and may provide a novel therapeutic strategy for chronic HCV ..
  7. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..Current nanocarriers mainly consist of liposomes and polymers, which are larger in size (>100nm in diameter) and tend to stay at injection sites while smaller nanoparticles ..
  8. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..Carbomers (polymers of acrylic acid) have been used in the pharmaceutical industry to achieve controlled release of medications in ..
  9. Evaluation of a new class of antimicrobial agents against Clostridium difficile
    SAUL R contact TZIPORI; Fiscal Year: 2011
    ..While other interventions have been tried (probiotics, toxin-absorbing polymers, and toxoid vaccines), neither prevention nor treatment strategies have kept up with the increasing numbers of ..
  10. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..The technology is based on the ability of synthetic polymers of N-substituted glycine termed 'peptoids'to serve as specific ligands for immunoglobulin...
  11. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    ..Our approach combines the development of novel adjuvants based on biodegradable polymers with molecular studies to elucidate mechanisms by which antigen-loaded adjuvants stimulate immune responses...
    JANET L YOTHER; Fiscal Year: 2012
    ..studies could have broad relevance for understanding mechanisms involved in synthesis and modulation of similar polymers produced by other pathogenic bacteria...
  13. Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Jeffrey B Kaplan; Fiscal Year: 2013
    ..The extracellular matrix of most biofilms contains polymers such as polysaccharides and DNA...
  14. Novel biofilm polymicrobial infection-resistant implants for otologic application
    Paul Stoodley; Fiscal Year: 2010
    ..RELEVANCE: In Phase I, we developed a combination of antimicrobial/antibiotic compounds incorporated in host polymers that significantly inhibits bacterial attachment and biofilm development of organisms associated with otitis ..
  15. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Joseph Vacanti on a project seeding polymers with endothelial cells to create a vascular graft for treating cerebral aneurysms...
  16. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..Vinculin is an essential protein involved controlling cell shape and motility, in part by anchoring actin polymers to the membrane...
  17. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..ER-produced proteins are frequently N-glycosylated with asparagine-bound sugar polymers (glycans)...
  18. Human Pluripotent Stem Cell Differentiation with Defined O2 & Protein Engagement
    ROBERT SAMUEL LANGER; Fiscal Year: 2010
    ..will be investigated in various forms: (1) unmodified, (2) chemically modified and functionalized with synthetic polymers, and (3) chemically modified with synthetic polymers to which ECM components are attached by physical adsorption ..
  19. Targeting Nanoparticle DNA Delivery to Prostate Tumors
    Janet A Sawicki; Fiscal Year: 2010
    ..is to introduce modifications to a promising new class of cationic, biodegradable, poly([unreadable]-amino ester) polymers that result in efficient, targeted nanoparticle-delivery of DNA to prostate tumor cells and associated ..
    David Stephen Pisetsky; Fiscal Year: 2013
    ..These experiments will also explore novel cationic polymers to block these responses...
  21. Rigid-rod Peptides as Nanocarriers for Delivery of Cancer Drugs
    Katarzyna Slowinska; Fiscal Year: 2013
    ..containing PTX conjugated with the hydrophilic and hydrolyzable groups such as polycarboxylic acids, sugars, polymers and peptides, were synthesized and tested...
    Edward H Egelman; Fiscal Year: 2012
    ..developed that greatly increase our ability to understand the structure and function of many different helical polymers. What emerges in our studies of proteins like bacterial RecA and human Rad51 is that the polymers they form are ..
  23. Recombinant Polymers for Transarterial Chemoembolization of Liver Cancer
    AZADEH POURSAID; Fiscal Year: 2013
  24. Chemoprevention of Head &Neck Cancer Using Controlled Release Polymers
    Susan R Mallery; Fiscal Year: 2013
    ..abstract_text> ..
  25. Development of a Next Generation Vaccine for Smoking Cessation and Relapse Preven
    Grayson B Lipford; Fiscal Year: 2010
    ..immune memory;4) Adjuvant (Toll-like receptor agonist) for cell specific immune activation, and 5) Biocompatible polymers for the time release of active components...
  26. Engineering DNA Delivery Polymers using Combinatorial and Cheminformatics Methods
    Kaushal Rege; Fiscal Year: 2013
    ..monomer synthesis, parallel polymer synthesis and cheminformatic modeling for the design and evaluation of polymers for transgene delivery...
  27. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    ..A promising approach has been the use of synthetic polymers as scaffolds for cell-polymer composites which are implanted;these materials have resulted in 16-fold enhancement ..
  28. Thromboresistant Polymers via Catalytic Generation of NO
    Mark E Meyerhoff; Fiscal Year: 2012
    ..Results from Phase I studies have demonstrated that polymers modified with given Cu(II)-complexes as well as organoselenium (RSe) species are capable of generating ..
  29. Characterization of a bacteriophage tubulin involved in viral replication
    JOSEPH A POGLIANO; Fiscal Year: 2013
    ..only will we seek to answer these questions, but our work will also provide new insights into how tubulin family polymers can participate in such divergent functions as cell division, separation of plasmid DNA and organizing DNA into ..
  30. N-acetylglucosamine signaling in fungi
    James B Konopka; Fiscal Year: 2012
    ..a key component of GPI anchors and N-linked glycosylation on proteins, and is a core constituent of extracellular polymers, such as keratin or hyaluronan in humans and cell wall chitin in fungi and parasites...
  31. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2013
    ..FXI activation is enhanced by polymers of inorganic phosphate (poly-P) released from platelet dense granules...
  32. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..Finally, we will evaluate enhanced SHIV protection through mixtures of gel-forming polymers and AAV to increase in vivo AAV transduction and b12scFv-Fc secretion (Rh=9)...
  33. Engineering Polymers For Gene Therapy of Head Cancer
    Hamid Ghandehari; Fiscal Year: 2013
    ..The following Specific Aims will be addressed: 1) Synthesize and characterize silk- elastinlike polymers containing MMP degradable sequences in the backbone...
  34. Screens for novel compounds to correct diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2011
    ..Each HSPG molecule consists of a protein strand onto which the cell assembles sugar polymers, called heparan sulfate, that we showed could capture lipoproteins...
  35. A Novel Electrospun Vascular Graft
    David J Vachon; Fiscal Year: 2010
    ..Surgical approaches involve bypass grafts, many of which are made of synthetic polymers (e.g. ePTFE). For other cardiovascular diseases biomaterials also play an important role...
  36. NIR Light-Activated Nanoparticles for Drug and Gene Delivery
    ..HGN can be easily conjugated to small molecules, targeting ligands, polymers, siRNA and DNA by simple thiol chemistry, or incorporated into or tethered to liposomes...
  37. Carbamazepine for severe liver disease due to antitrypsin deficiency
    David H Perlmutter; Fiscal Year: 2012
    ..responsible for degrading soluble forms of mutant ATZ and autophagy is specialized for disposal of the insoluble polymers and aggregates...
    Barbara A Baird; Fiscal Year: 2013
    ..substrates for patterning antigen on micro- and nanometer lengths scales, including use of thermosensitive polymers for rapidly triggered exposure of antigen...
  39. Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused Ultrasound
    Richard J Price; Fiscal Year: 2013
    ..Subsequently, BPNs with these optimal characteristics will be generated from biodegradable polymers and tested...
  40. Ubiquitin and regulation of prion induction by a short-lived protein
    Keith D Wilkinson; Fiscal Year: 2013
    ..Most prions form highly ordered fibrous polymers (amyloids), resembling the aggregates involved in other amyloidoses and neural inclusion diseases, such as ..
  41. Mechanism of cellulose synthesis and transport across biological membranes
    Jochen Zimmer; Fiscal Year: 2013
    ..Overall, we undertake a multi-disciplinary approach to reveal how one of nature's most abundant polymers is synthesized and translocated across biological membranes.
  42. Structural Biochemistry of PARP-1
    John Pascal; Fiscal Year: 2013
    ..PARP-1 has a unique catalytic activity that synthesizes polymers of ADP-ribose as a posttranslational modification on target proteins, primarily on PARP-1 itself (..
  43. Molecular Mechanisms of Cytoskeletal Regulators
    Kevin C Slep; Fiscal Year: 2013
    ..Microtubules are polymers of a[unreadable]-tubulin heterodimers...
  44. Regulation and Function of a Bacterial Cytoskeleton
    R Dyche Mullins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A major goal of my laboratory is to understand how cytoskeletal polymers establish long-range order in the cytoplasm and help convert a rowdy mob of macromolecules into a living cell...
  45. Design and mechanistic studies of mimics of antimicrobial peptides
    William F Degrado; Fiscal Year: 2012
    ..In the previous funding period we designed a number of small molecules, sequence-specific oligomers, and polymers that address many of these problems. These compounds have robust in vivo activity against S...
  46. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..Ostene is a combination of biocompatible water-soluble polymers which are absorbed completely within 24 to 48 hours of implantation;it is non-inflammatory and also has an ..
  47. Effect of beta-glucan on sepsis
    COURTNI NEWSOME; Fiscal Year: 2009
    Beta-glucan is a class of long-chain glucose polymers in beta-(1,3)(1,6) linkage...
  48. Peptidoglycan synthesis during sporulation
    Jonathan Dworkin; Fiscal Year: 2012
    ..The essential enzymes that synthesize these monomers and assemble them into polymers are well characterized and are the targets of many important antibiotics...
  49. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    JACK CABELL GRIFFIS; Fiscal Year: 2012
    ..MedShape Solutions has developed a series of bioabsorbable polymers capable of carrying various therapeutic agents...
  50. Novel Polymer Coatings to Prevent Biofilms on Urinary Stents and Catheters
    JEFFREY LAWRENCE DALSIN; Fiscal Year: 2011
    ..In brief, antifouling polymers have been coupled to the amino acid L-3,4-dihydroxyphenylalanine (DOPA), a key component of so-called mussel ..
    SATHYANARAYANA N MURTHY; Fiscal Year: 2013
    ..Three lead (in situ gelling solution) formulations will be developed using suitable polymers to facilitate prolonged retention and drug delivery...
  52. Self-assembling Biomimetic Hydrogels with Bioadhesive Properties for Intervertebr
    ..A need for bioadhesive polymers exists in the area of regenerative medicine...
  53. Actin dynamics and regulation of epithelial barrier in intestinal inflammation
    ANDREI IVANOVICH IVANOV; Fiscal Year: 2013
    ..Actin filaments are highly dynamic polymers undergoing a constant turnover (depolymerization and polymerization)...
  54. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012
    ..and CS which involves strong acid, base and other environmentally harmful chemicals, and (2) the use of man-made polymers to strengthen mechanical properties of CS-based materials;these are not desirable as they may inadvertently alter ..
  55. Myelin Composition Influence on Bilayer Interactions in Multiple Sclerosis
    Jacob N Israelachvili; Fiscal Year: 2010
    ..We hypothesize that polyethylene glycol (PEG) and poloxamers, non-toxic and FDA-approved polymers, recently used to treat spinal cord injuries in animals, might act to heal the myelin sheath via adding an ..
  56. Luminescent Oxygen Nanosensors for Tumor Hypoxia Imaging
    Cassandra L Fraser; Fiscal Year: 2013
    ..e. both fluorescence (F) and phosphorescence (P) detection). 2) BNP polymers will be adapted for passive and active targeting for pO2 monitoring with improved spatial specificity;targeted ..
  57. Regulation of inflammatory responses by nucleic-acid binding polymers
    EDUARTA K HOLL; Fiscal Year: 2013
    ..To test our hypothesis we propose to explore the potential utility of nucleic acid binding polymers as anti-inflammatory agents in the context of SLE...
  58. Elucidation of Antisickling Molecules in a Botanical with Antisickling Activity
    Robert Swift; Fiscal Year: 2013
    ..When deoxygenated, Hb S polymerizes, forming long polymers that deform the biconcave red blood cells (RBCs) into rigid, adherent, sickle-shaped cells...
  59. Polyketals to encapsulate a small molecule p38 inhibitor for cardiac regeneration
    Michael E Davis; Fiscal Year: 2013
    ..Polyketal particles are a new class of polymers that are stable, degrade in to FDA-approved compounds, can be modified easily and can encapsulate proteins while ..
  60. Analysis of Polyhydroxyalkanoate Inclusion Biogenesis
    Douglas Dennis; Fiscal Year: 2009
    ..Polyhydroxyalkanoates (PHAs) are bacterial polymers that are synthesized in inclusions when carbon levels are high and another essential nutrient, such as nitrogen ..
  61. HEPylated G-CSF: Drug with Safer, Enhanced Delivery for Neutropenia Treatment
    Wei Jing; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Poly[ethylene glycol] (PEG) polymers are widely used by pharma to enhance the physical, chemical, and/or biological nature of promising drug candidates...
  62. Kinetochore-Microtubule Interactions
    JOHN RICHARD MCINTOSH; Fiscal Year: 2012
    ..We are also constructing derivatized planar surfaces, modified by the binding of long, hydrophilic polymers, as platforms for presenting complexes of kinetochore proteins to dynamic microtubule ends, so they can interact ..
    ROBERT SAMUEL LANGER; Fiscal Year: 2013
    ..Our specific aims are: 1. To develop next-generation biodegradable polymers for use as efficient and non-toxic vectors for lung cancer and DNA vaccines. 2...
  64. First Clinical Trial of an Anti-Sickling Botanical Drug for Sickle Cell Dise
    Robert Swift; Fiscal Year: 2013
    ..When deoxygenated, Hb S polymerizes, forming long polymers that deform the biconcave red blood cells (RBCs) into rigid, adherent, sickle-shaped cells...
  65. New Frontiers at the Interface of Immunity and Glycobiology
    Andrew D Robertson; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Glycans are naturally occurring polymers of sugars that are important for essentially all of the key functions of the immune system...
  66. Hybridization Chain Reaction: In Situ Amplification for Biological Imaging
    Niles A Pierce; Fiscal Year: 2013
    ..chain reactions in which fluorophore-labeled RNA hairpins self-assemble into tethered fluorescent amplification polymers. During the first funding period, we engineered orthogonal HCR amplifiers that operate independently in the same ..
    Cato Laurencin; Fiscal Year: 1990
    ..With the increasing use of polymers as implants in oral/maxillofacial, orthopaedic and other medical areas, and with the importance of therapeutic ..
    JAN STANNARD; Fiscal Year: 1993
    ..The wear behavior of composites have been evaluated in many respects however the role of the many different polymers used has not been fully investigated...
    Csaba Horvath; Fiscal Year: 1993
    Funds are requested to support travel of participants to the "Reactive Polymers, Ion-Exchangers and Adsorbents" Gordon Research Conference to be held August 22-27, 1993 at the Salve Regina University in Newport, RI...
  70. Expandable Shape-Memory Polymers for Suture Anchors
    Christopher M Yakacki; Fiscal Year: 2011
    ..fixation strength in soft bone and increased cyclic performance due to the design's use of shape-memory polymers. The shape-memory suture anchor will also offer reduced complexity and time during installation as a tap-in ..
  71. Elastic biodegradable ureteral stent
    Haesun Park; Fiscal Year: 2009
    ..Current ureteral stents are made of non-degradable polymers and, unless they are permanent, have to be removed by second procedure, which requires further intervention on ..
    Vladimir Torchilin; Fiscal Year: 2006
    ..To couple many reporter groups to a single antibody molecule, the single-point modification of an antibody with polymers carrying multiple chelating residues (polychelating polymers, PPs) was proposed providing the major increase in ..
    Chih Chang Chu; Fiscal Year: 1990
    ..model compound to test the feasibility of a novel concept to control the biodegradation of synthetic absorbable polymers. The ability to in situ/externally regulate the rate of tensile strength loss SAS would make SAS more suitable in ..
  74. Multi-componet Vaccine for Staphylcoccus epidermidis
    Tomas Maira Litran; Fiscal Year: 2009
    ..S. epidermidis and other related CoNS elaborate, as extracellular polymers, poly-?-DL-glutamic acid (DL-PGA) to facilitate growth and survival in the human host...
  75. Self-microencapsulation in polymer delivery systems without organic solvents
    Steven P Schwendeman; Fiscal Year: 2010
    ..substances, particularly biomacromolecules such as proteins and peptides, in biodegradable controlled-release polymers. Current methods of microencapsulation in polymers such as poly(lactic-co-glycolic acid) (PLGA) suffer from: a) ..