electron transport complex iv

Summary

Summary: A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

Top Publications

  1. ncbi DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates
    O Folmer
    Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
    Mol Mar Biol Biotechnol 3:294-9. 1994
  2. pmc Biological identifications through DNA barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Proc Biol Sci 270:313-21. 2003
  3. ncbi DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification success
    Rudolf Meier
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
    Syst Biol 55:715-28. 2006
  4. pmc Identification of Birds through DNA Barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario, Canada
    PLoS Biol 2:e312. 2004
  5. pmc DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae)
    M Alex Smith
    Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 103:3657-62. 2006
  6. ncbi HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
  7. pmc DNA barcoding Australia's fish species
    Robert D Ward
    CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    Philos Trans R Soc Lond B Biol Sci 360:1847-57. 2005
  8. ncbi The campaign to DNA barcode all fishes, FISH-BOL
    R D Ward
    CSIRO Wealth from Oceans Flagship, CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    J Fish Biol 74:329-56. 2009
  9. pmc mtDNA mutations increase tumorigenicity in prostate cancer
    John A Petros
    Department of Urology, Emory University, 1365A Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:719-24. 2005
  10. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009

Detail Information

Publications281 found, 100 shown here

  1. ncbi DNA primers for amplification of mitochondrial cytochrome c oxidase subunit I from diverse metazoan invertebrates
    O Folmer
    Center for Theoretical and Applied Genetics, Rutgers University, New Brunswick, New Jersey 08903 231
    Mol Mar Biol Biotechnol 3:294-9. 1994
    ..Preliminary comparisons revealed that these COI primers generate informative sequences for phylogenetic analyses at the species and higher taxonomic levels...
  2. pmc Biological identifications through DNA barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Proc Biol Sci 270:313-21. 2003
    ..Its assembly will also generate important new insights into the diversification of life and the rules of molecular evolution...
  3. ncbi DNA barcoding and taxonomy in Diptera: a tale of high intraspecific variability and low identification success
    Rudolf Meier
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore, Singapore
    Syst Biol 55:715-28. 2006
    ..We conclude with an outlook on the prospects of obtaining complete barcode databases and the future use of DNA sequences in a modern integrative taxonomy...
  4. pmc Identification of Birds through DNA Barcodes
    Paul D N Hebert
    Department of Zoology, University of Guelph, Guelph, Ontario, Canada
    PLoS Biol 2:e312. 2004
    ..The growing evidence for the effectiveness of DNA barcodes as a basis for species identification supports an international exercise that has recently begun to assemble a comprehensive library of COI sequences linked to named specimens...
  5. pmc DNA barcodes reveal cryptic host-specificity within the presumed polyphagous members of a genus of parasitoid flies (Diptera: Tachinidae)
    M Alex Smith
    Biodiversity Institute of Ontario, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 103:3657-62. 2006
    ..If general, these results will increase estimates of global species richness and imply that tropical conservation and host-parasite interactions may be more complex than expected...
  6. ncbi HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
    ..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
  7. pmc DNA barcoding Australia's fish species
    Robert D Ward
    CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    Philos Trans R Soc Lond B Biol Sci 360:1847-57. 2005
    ..We conclude that cox1 sequencing, or 'barcoding', can be used to identify fish species...
  8. ncbi The campaign to DNA barcode all fishes, FISH-BOL
    R D Ward
    CSIRO Wealth from Oceans Flagship, CSIRO Marine and Atmospheric Research, GPO Box 1538, Hobart, Tasmania 7001, Australia
    J Fish Biol 74:329-56. 2009
    ..However, current results indicate these issues are of little concern for the great majority of specimens...
  9. pmc mtDNA mutations increase tumorigenicity in prostate cancer
    John A Petros
    Department of Urology, Emory University, 1365A Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:719-24. 2005
    ..The mutant tumors also generated significantly more ROS. Therefore, mtDNA mutations do play an important role in the etiology of prostate cancer...
  10. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..Mitochondrial dysfunction provides a plausible mechanistic rationale for the hypometabolism in brain that precedes AD diagnosis and suggests therapeutic targets for prevention of AD...
  11. ncbi The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A
    T Tsukihara
    Institute for Protein Research, Osaka University, Suita, Japan
    Science 272:1136-44. 1996
    ..Possible channels for chemical protons to produce H2O, for removing the produced water, and for O2, respectively, were identified...
  12. pmc A universal DNA mini-barcode for biodiversity analysis
    Isabelle Meusnier
    Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    BMC Genomics 9:214. 2008
    ..It may be difficult in practice, however, to retrieve a 650 bp fragment from archival specimens, (because of DNA degradation) or from environmental samples (where universal primers are needed)...
  13. ncbi Co-translational membrane insertion of mitochondrially encoded proteins
    Martin Ott
    Cell Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Biochim Biophys Acta 1803:767-75. 2010
    ..The specific hallmarks and the critical components of this machinery are discussed in this review article...
  14. pmc Rcf1 and Rcf2, members of the hypoxia-induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex
    Vera Strogolova
    Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA
    Mol Cell Biol 32:1363-73. 2012
    ..Based on our findings, we propose a model where the Hig1 proteins regulate the COX enzyme activity through Cox3 and associated Cox12 protein, in a manner that may be influenced by the neighboring AAC proteins...
  15. pmc Mitochondrial cox1 sequence data reliably uncover patterns of insect diversity but suffer from high lineage-idiosyncratic error rates
    Lars Hendrich
    Department of Entomology, Zoological State Collection, Munich, Germany
    PLoS ONE 5:e14448. 2010
    ..Then, we contrasted phylogenetic subsampling with the hitherto more commonly applied geographical subsampling, where sister species are not necessarily captured...
  16. pmc Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation
    David U Mick
    Abteilung für Biochemie II, Universitat Gottingen, D 37073 Gottingen, Germany
    Nat Rev Mol Cell Biol 12:14-20. 2011
    ..New findings on the early steps of cytochrome c oxidase assembly reveal how the mitochondrial translation of its core component, cytochrome c oxidase subunit 1 (Cox1), is directly coupled to the assembly of this respiratory complex...
  17. ncbi Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    Takayuki Akimoto
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:19587-93. 2005
    ..These findings suggest that contractile activity-induced activation of the p38 MAPK pathway promotes Pgc-1alpha gene expression and skeletal muscle adaptation...
  18. ncbi Taenia asiatica and Taenia saginata: genetic divergence estimated from their mitochondrial genomes
    H K Jeon
    Department of Parasitology and Medical Research Institute, Chungbuk National University College of Medicine, Chongju, Chungbuk 361 763, Republic of Korea
    Exp Parasitol 113:58-61. 2006
    ..8%. The actual sequence divergence was computed 4.5% from the cox1 gene, and 4.1% from the cob gene. These results support the designation of T. asiatica as a separate species from T. saginata...
  19. pmc DNA barcodes distinguish species of tropical Lepidoptera
    Mehrdad Hajibabaei
    Department of Integrative Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
    Proc Natl Acad Sci U S A 103:968-71. 2006
    ..If these results are general, DNA barcoding will significantly aid species identification and discovery in tropical settings...
  20. pmc A ranking system for reference libraries of DNA barcodes: application to marine fish species from Portugal
    Filipe O Costa
    CBMA Centre of Molecular and Environmental Biology, Department of Biology, University of Minho, Campus de Gualtar, Braga, Portugal
    PLoS ONE 7:e35858. 2012
    ..We propose a ranking system to attribute a confidence level to species identifications associated with DNA barcode records from a RLDB. Here we apply the proposed ranking system to a newly generated RLDB for marine fish of Portugal...
  21. pmc Neotropical bats: estimating species diversity with DNA barcodes
    Elizabeth L Clare
    Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 6:e22648. 2011
    ..Our analysis provides strong support for the continued assembly of DNA barcoding libraries and ongoing taxonomic investigation of bats...
  22. ncbi Slow mitochondrial DNA sequence evolution in the Anthozoa (Cnidaria)
    T L Shearer
    Department of Biological Sciences, 109 Cooke Hall, University at Buffalo, Buffalo, NY 14260, USA
    Mol Ecol 11:2475-87. 2002
    ..Slow evolution and unique characteristics may be common in primitive metazoans, suggesting that patterns of mtDNA evolution in these organisms differ from that in other animal systems...
  23. pmc Cryptic diversity in Indo-Pacific coral-reef fishes revealed by DNA-barcoding provides new support to the centre-of-overlap hypothesis
    Nicolas Hubert
    Laboratoire ECOMAR, Faculté des Sciences et Technologies, Universite de la Reunion, Saint Denis, Reunion, France
    PLoS ONE 7:e28987. 2012
    ....
  24. pmc The role of the LRPPRC (leucine-rich pentatricopeptide repeat cassette) gene in cytochrome oxidase assembly: mutation causes lowered levels of COX (cytochrome c oxidase) I and COX III mRNA
    Fenghao Xu
    Metabolism Research Programme, The Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8
    Biochem J 382:331-6. 2004
    ..A more diffuse distribution of LRPPRC in LSFC cells compared with controls was evident when viewed by immunofluorescence microscopy, with less LRPPRC present in peripheral mitochondria...
  25. ncbi p53 regulates mitochondrial respiration
    Satoaki Matoba
    Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1650-3. 2006
    ..That SCO2 couples p53 to mitochondrial respiration provides a possible explanation for the Warburg effect and offers new clues as to how p53 might affect aging and metabolism...
  26. pmc Arrangement of the respiratory chain complexes in Saccharomyces cerevisiae supercomplex III2IV2 revealed by single particle cryo-electron microscopy
    Eugenia Mileykovskaya
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 287:23095-103. 2012
    ..The supercomplex contains about 50 molecules of cardiolipin (CL) with a fatty acid composition identical to that of the inner membrane CL pool, consistent with CL-dependent stabilization of the supercomplex...
  27. ncbi Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation
    Daniel J M Fernández-Ayala
    Institute of Medical Technology, Tampere University Hospital, University of Tampere, 33014 Tampere, Finland
    Cell Metab 9:449-60. 2009
    ..AOX appears to offer promise as a wide-spectrum therapeutic tool in OXPHOS disorders...
  28. ncbi Molecular prospecting for cryptic species of nematodes: mitochondrial DNA versus internal transcribed spacer
    Michael S Blouin
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Int J Parasitol 32:527-31. 2002
    ..On the other hand, internal transcribed spacer remains an excellent tool for DNA diagnostics (quickly distinguishing between known species) owing to its lower level of intraspecific polymorphism...
  29. ncbi Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease
    Maik Huttemann
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Bioenerg Biomembr 40:445-56. 2008
    ..This model is presented in light of the recently emerging understanding of mechanisms that regulate mammalian cytochrome c oxidase and its substrate cytochrome c as representative enzymes for the entire OxPhos system...
  30. ncbi Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase
    B Kadenbach
    Fachbereich Chemie, Philipps Universitat, Marburg, Germany
    Free Radic Biol Med 29:211-21. 2000
    ..High substrate pressure (sigmoidal v/s kinetics), palmitate and 3,5-diiodothyronine (binding to subunit Va) increase also delta p, ROS production and slip but without dephosphorylation of COX...
  31. pmc Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core
    Ileana C Soto
    Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Biochim Biophys Acta 1817:883-97. 2012
    ..This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes...
  32. ncbi Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b
    Daniela Fornuskova
    Department of Pediatrics, First Faculty of Medicine, Charles University in Prague, Ke Karlovu 2, Prague 2, 12808 Czech Republic
    Biochem J 428:363-74. 2010
    ....
  33. ncbi Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene
    L C Papadopoulou
    Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece
    Nat Genet 23:333-7. 1999
    ..The clinical phenotype caused by mutations in human SCO2 differs from that caused by mutations in SURF1, the only other known COX assembly gene associated with a human disease, Leigh syndrome...
  34. ncbi A comprehensive DNA sequence library is essential for identification with DNA barcodes
    Torbjørn Ekrem
    Section of Natural History, Museum of Natural History and Archaeology, Norwegian University of Science and Technology, NO 7491 Trondheim, Norway
    Mol Phylogenet Evol 43:530-42. 2007
    ..Thus, if a well-matching cox1 sequence is not already available in the library, the prospects of approximately identifying an unknown taxon, even to the correct genus of subtribe Tanytarsina, are not good...
  35. ncbi Cytochrome c oxidase--structure, function, and physiology of a redox-driven molecular machine
    O M H Richter
    Institute of Biochemistry, Biocenter, J W Goethe Universitat, Marie Curie Str 9, 60439 Frankfurt, Germany
    Rev Physiol Biochem Pharmacol 147:47-74. 2003
    ..Moreover, the successful elucidation of 3-D structures for both the mitochondrial and several bacterial oxidases has greatly helped in designing mutagenesis approaches to study functional aspects in these enzymes...
  36. ncbi Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase
    Margaret T T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:4761-71. 2005
    ..The results are consistent with our hypothesis that the mechanism of photobiomodulation involves the up-regulation of cytochrome c oxidase, leading to increased energy metabolism in neurons functionally inactivated by toxins...
  37. ncbi Patterns of evolution of mitochondrial cytochrome c oxidase I and II DNA and implications for DNA barcoding
    Amanda D Roe
    CW403 Biological Sciences Building, Department of Biological Sciences, University of Alberta, Edmonton, Alta, Canada
    Mol Phylogenet Evol 44:325-45. 2007
    ..Consequently, we recommend that researchers should maximize sequence length to increase the probability of sampling regions of high phylogenetic informativeness, and to minimize stochastic variation in estimating total divergence...
  38. ncbi Rapid diagnostic PCR assays for members of the Culicoides obsoletus and Culicoides pulicaris species complexes, implicated vectors of bluetongue virus in Europe
    Damien V Nolan
    School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, Scotland, UK
    Vet Microbiol 124:82-94. 2007
    ..pulicaris complex or in a multiplex PCR to identify members of the C. obsoletus complex. This approach provides a valuable diagnostic tool for monitoring species composition in mixed field collections of Culicoides...
  39. ncbi A three-gene dinoflagellate phylogeny suggests monophyly of prorocentrales and a basal position for amphidinium and heterocapsa
    Huan Zhang
    Department of Marine Sciences, University of Connecticut, Groton, CT 06340, USA
    J Mol Evol 65:463-74. 2007
    ..The position of these lineages needs to be further verified...
  40. ncbi Genetic patterns across multiple introductions of the globally invasive crab genus Carcinus
    John A Darling
    US Environmental Protection Agency, National Exposure Research Laboratory, Molecular Ecology Research Branch, Cincinnati, OH 45268, USA
    Mol Ecol 17:4992-5007. 2008
    ..maenas invasions vary broadly in the degree to which they retain genetic diversity, although populations with the least variation typically derive from secondary invasions or from introductions that occurred more than 100 years ago...
  41. ncbi Slow mitochondrial COI sequence evolution at the base of the metazoan tree and its implications for DNA barcoding
    Danwei Huang
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore
    J Mol Evol 66:167-74. 2008
    ..Caution is also advised for Porifera and Hydrozoa because of relatively low identification success rates as even threshold divergence that maximizes the "barcoding gap" does not improve identification success...
  42. pmc The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process
    Tomitake Tsukihara
    Institute for Protein Research, Osaka University, 3 2 Yamada Oka, Suita 565 0871, Japan
    Proc Natl Acad Sci U S A 100:15304-9. 2003
    ..Infrared results indicate that the conformation of Asp-51 is controlled only by the oxidation state of the low-spin heme. These results indicate that the low-spin heme drives the proton-pumping process...
  43. ncbi Barcoding aphids (Hemiptera: Aphididae) of the Korean Peninsula: updating the global data set
    Wonhoon Lee
    Insect Biosystematics Laboratory, Research Institute for Agricultural and Life Sciences, Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Mol Ecol Resour 11:32-7. 2011
    ..Based on these results, we conclude that DNA barcodes can provide an effective tool for identifying aphid species in such applications as pest management, monitoring and plant quarantine...
  44. ncbi Species within the Bemisia tabaci (Hemiptera: Aleyrodidae) complex in soybean and bean crops in Argentina
    V Alemandri
    Instituto de Fitopatología y Fisiología Vegetal Instituto Nacional de Tecnología Agropecuaria IFFIVE INTA, Camino 60 cuadras Km 5 1 2, X5020ICA Córdoba, Argentina
    J Econ Entomol 105:48-53. 2012
    ..These primers were either unable to distinguish between the two indigenous members of the complex in Argentina or indicated a difference when none was evident on the basis of mtCOI sequence comparison...
  45. ncbi Cytochrome C oxidase activity and oxygen tolerance
    Jian Li Campian
    Molecular Targets Group, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 282:12430-8. 2007
    ..These observations may suggest new pharmaceutical strategies to diminish oxygen-mediated cellular damage...
  46. ncbi Identifying Canadian mosquito species through DNA barcodes
    A Cywinska
    Department of Biological Sciences, Brock University, St Catharines, Ontario, Canada
    Med Vet Entomol 20:413-24. 2006
    ..4% (range 0.2-17.2%), whereas those for conspecific individuals averaged 0.5% (range 0.0-3.9%)...
  47. pmc Probing evolutionary patterns in neotropical birds through DNA barcodes
    Kevin C R Kerr
    Department of Integrative Biology, Biodiversity Institute of Ontario, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 4:e4379. 2009
    ..This study begins to address this gap by assembling a library of mitochondrial COI sequences, or DNA barcodes, for Argentinian birds and comparing their patterns of genetic diversity to those of North American birds...
  48. ncbi Cryptic ecological diversification of a planktonic estuarine copepod, Acartia tonsa
    Gang Chen
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Mol Ecol 17:1451-68. 2008
    ....
  49. ncbi Discrimination of Culicoides midge larvae using multiplex polymerase chain reaction assays based on DNA sequence variation at the mitochondrial cytochrome C oxidase I gene
    Jan M Schwenkenbecher
    Institute of Biological and Environmental Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, United Kingdom
    J Med Entomol 46:610-4. 2009
    ..l. complex. These assays yield two PCR products: one species-specific and one generic band. We show the application of the assays in the analysis of Culicoides larvae from three different farms in northeast Scotland...
  50. ncbi Phylogeography of Aedes (Stegomyia) aegypti (L.) and Aedes (Stegomyia) albopictus (Skuse) (Diptera: Culicidae) based on mitochondrial DNA variations
    Laurence Mousson
    Insectes et Maladies Infectieuses formerly Ecologie des Systèmes Vectoriels, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Genet Res 86:1-11. 2005
    ..This suggests that African populations of A. aegypti introduced during the slave trade have persisted in Boa Vista, resisting eradication campaigns...
  51. pmc The proton pumping pathway of bovine heart cytochrome c oxidase
    Kunitoshi Shimokata
    Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 104:4200-5. 2007
    ..These results significantly strengthen the proposal that H-pathway is involved in proton pumping...
  52. pmc Phylogeography and genetic diversity of a widespread Old World butterfly, Lampides boeticus (Lepidoptera: Lycaenidae)
    David J Lohman
    Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Republic of Singapore
    BMC Evol Biol 8:301. 2008
    ..Here, we investigate the demographic history and taxonomic status of this widespread species, and screen for the presence or absence of the bacterial endosymbiont Wolbachia...
  53. pmc Mutations in C12orf62, a factor that couples COX I synthesis with cytochrome c oxidase assembly, cause fatal neonatal lactic acidosis
    Woranontee Weraarpachai
    Department of Human Genetics and Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Am J Hum Genet 90:142-51. 2012
    ..We conclude that C12orf62 is required for coordination of the early steps of COX assembly with the synthesis of COX I...
  54. pmc Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene
    Eyal Shteyer
    The Metabolic Disease Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Hum Genet 84:412-7. 2009
    ..Mutation analysis of COX4I2 is warranted in patients with malabsorption due to exocrine pancreatic insufficiency and in patients with dyserythropoeitic anemia...
  55. ncbi Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly
    Erica Balatri
    Magnetic Resonance Center CERM and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy
    Structure 11:1431-43. 2003
    ..The availability of the structure has allowed us to model the homologs Sco1 and Sco2 from S. cerevisiae and to discuss the physiological role of the Sco family...
  56. pmc Activity-based protein profiling reveals mitochondrial oxidative enzyme impairment and restoration in diet-induced obese mice
    Natalie C Sadler
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
    PLoS ONE 7:e47996. 2012
    ....
  57. pmc Mechanism of Cu(A) assembly
    Luciano A Abriata
    Instituto de Biologia Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK Rosario, Argentina
    Nat Chem Biol 4:599-601. 2008
    ..The purported metallochaperone Sco1 is unable to deliver copper ions; instead, it works as a thiol-disulfide reductase to maintain the correct oxidation state of the Cu(A) cysteine ligands...
  58. ncbi Comparative phylogeography among hydrothermal vent species along the East Pacific Rise reveals vicariant processes and population expansion in the South
    S Plouviez
    Laboratoire Adaptation et Diversité en Milieu Marin, Universite Pierre et Marie Curie Paris 6, Paris, France
    Mol Ecol 18:3903-17. 2009
    ....
  59. pmc A histidine residue acting as a controlling site for dioxygen reduction and proton pumping by cytochrome c oxidase
    Kazumasa Muramoto
    Department of Life Science, University of Hyogo, 3 2 1 Kouto, Kamigori, Ako, Hyogo 678 1297, Japan
    Proc Natl Acad Sci U S A 104:7881-6. 2007
    ..These results suggest that His-503 couples the proton transfer for dioxygen reduction with the proton pumping...
  60. ncbi Peripatric speciation drives diversification and distributional pattern of reef hermit crabs (Decapoda: Diogenidae: Calcinus)
    Maria Celia Machel D Malay
    Florida Museum of Natural History and Department of Biology, University of Florida, Gainesville, Florida 32611, USA
    Evolution 64:634-62. 2010
    ..Calcinus speciation patterns do not match well-worn models put forth to explain the origin of Indo-West Pacific diversity, but underscore the complexity of marine diversification...
  61. pmc Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae
    Flavia Fontanesi
    Departments of Neurology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:555-66. 2011
    ..These results suggest that once Ssc1-Mss51 are released from the Cox1 stabilization complex, Cox25 continues to interact with Cox14 and Cox1 to facilitate the formation of multisubunit COX assembly intermediates...
  62. pmc Cytochrome c oxidase: evolution of control via nuclear subunit addition
    Denis Pierron
    Wayne State University School of Medicine, Detroit, MI, USA
    Biochim Biophys Acta 1817:590-7. 2012
    ....
  63. ncbi DNA barcodes for two scale insect families, mealybugs (Hemiptera: Pseudococcidae) and armored scales (Hemiptera: Diaspididae)
    D S Park
    Biological Resource Center, KRIBB, Daejeon, Korea
    Bull Entomol Res 101:429-34. 2011
    ....
  64. ncbi A comprehensive molecular survey of Echinococcus granulosus in formalin-fixed paraffin-embedded tissues in human isolates in Turkey
    Sami Simsek
    Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119 Elazig, Turkey
    Parasitol Res 109:411-6. 2011
    ..In conclusion, the results from the analysis of human isolates of E. granulosus confirmed the occurrence of G1, G3 and G6 genotypes in Turkey and indicated G1/G3 cluster (E. granulosus sensu stricto) as the predominant genotype...
  65. ncbi Proton-pumping mechanism of cytochrome C oxidase
    Shinya Yoshikawa
    Department of Life Science, University of Hyogo, Hyogo, Japan
    Annu Rev Biophys 40:205-23. 2011
    ..Here, recent progress in experimental evaluations of these proposals is reviewed and strategies for improving our understanding of the mechanism of this physiologically important process are discussed...
  66. ncbi The O(2) reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase
    Shinya Yoshikawa
    Department of Life Science, University of Hyogo, Hyogo, Japan
    Biochim Biophys Acta 1807:1279-86. 2011
    ..This article is part of a Special Issue entitled: Allosteric cooperativity in respiratory proteins...
  67. pmc Molecular approach to the identification of fish in the South China Sea
    Junbin Zhang
    Department of Aquaculture and Life Science, Shanghai Ocean University, Shanghai, China
    PLoS ONE 7:e30621. 2012
    ..As a contribution to FISH-BOL, we examined the degree to which DNA barcoding can discriminate marine fishes from the South China Sea...
  68. pmc Multiple phosphorylations of cytochrome c oxidase and their functions
    Stefan Helling
    Medizinisches Proteom Center, Funktionelle Proteomik, Ruhr Universitat Bochum, Bochum, Germany
    Proteomics 12:950-9. 2012
    ..We therefore hypothesize that additional phosphorylation(s) may be required for the "allosteric ATP-inhibition," and that these sites may be easily dephosphorylated or difficult to identify by mass spectrometry...
  69. ncbi Phylogeography and biogeography concordance in the marine gastropod Crepipatella dilatata (Calyptraeidae) along the southeastern Pacific coast
    Antonio Brante
    Departamento de Ecologia, Facultad de Ciencias, Universidad Católica de la Santísima Concepción, Concepcion, Chile
    J Hered 103:630-7. 2012
    ..In addition, in this and other marine invertebrate species, gene flow limitations across both sides of the 30°S break may act as a driver of the speciation process...
  70. pmc Assessment of three mitochondrial genes (16S, Cytb, CO1) for identifying species in the Praomyini tribe (Rodentia: Muridae)
    Violaine Nicolas
    Museum national d histoire naturelle, Département de Systématique et Evolution UMR CNRS 7205, Paris, France
    PLoS ONE 7:e36586. 2012
    ....
  71. ncbi Molecular evolution at the cytochrome oxidase subunit 2 gene among divergent populations of the intertidal copepod, Tigriopus californicus
    Paul D Rawson
    School of Marine Sciences, University of Maine, Orono, ME 04469, USA
    J Mol Evol 62:753-64. 2006
    ....
  72. ncbi Molecular comparison of topotypic specimens confirms Anopheles (Nyssorhynchus) dunhami Causey (Diptera: Culicidae) in the Colombian Amazon
    Freddy Ruiz
    Division of Entomology, Walter Reed Army Institute of Research, 503 Robert Grant Av, Maryland 20910, USA
    Mem Inst Oswaldo Cruz 105:899-903. 2010
    ..dunhami and differentiation from these closely related species are highly robust using either DNA ITS2 sequences or COI DNA barcode. DNA methods are advocated for future differentiation of these often sympatric taxa in South America...
  73. pmc Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria
    David U Mick
    Institut fur Biochemie und Molekularbiologie, Zentrum für Biochemie und Molekulare Zellforschung, Universitat Freiburg, D 79104 Freiburg, Germany
    J Cell Biol 191:141-54. 2010
    ..Our data indicate that Coa1 binding to sequestered Mss51 in complex with Cox14, Coa3, and Cox1 is essential for full inactivation...
  74. ncbi Cardiolipin biosynthesis and mitochondrial respiratory chain function are interdependent
    Vishal M Gohil
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Biol Chem 279:42612-8. 2004
    ..This is the first report of regulation of phospholipid biosynthesis by alteration of subcellular compartment pH...
  75. pmc Analysis of Leigh syndrome mutations in the yeast SURF1 homolog reveals a new member of the cytochrome oxidase assembly factor family
    Megan Bestwick
    University of Utah Health Sciences Center, Department of Medicine, Salt Lake City, Utah 84132, USA
    Mol Cell Biol 30:4480-91. 2010
    ..Cyc1 is known to be important at an ill-defined step in the assembly and/or stability of CcO. This new link to Coa4 may begin to further elucidate the role of Cyc1 in CcO biogenesis...
  76. ncbi Long-term high-fat-diet feeding impairs mitochondrial biogenesis in liver of male and female rats
    Antònia Nadal-Casellas
    Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut IUNICS, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Cell Physiol Biochem 26:291-302. 2010
    ..Given the sexual dimorphism previously found in mitochondrial function, the aim of this study was to investigate the gender-dependent effect of chronic high-fat-diet (HFD) feeding on rat liver mitochondrial function and biogenesis...
  77. ncbi Analysis of genetic variability within Thelazia callipaeda (Nematoda: Thelazioidea) from Europe and Asia by sequencing and mutation scanning of the mitochondrial cytochrome c oxidase subunit 1 gene
    D Otranto
    Department of Animal Health and Welfare, University of Bari, Faculty of Veterinary Medicine, P O Box 7, Str Prov per Casamassima Km3, 70010 Valenzano, Bari, Italy
    Mol Cell Probes 19:306-13. 2005
    ..The results for the SSCP analysis and sequencing were concordant, indicating that the mutation scanning approach provides a useful tool for investigating the population genetics and molecular ecology of T. callipaeda...
  78. ncbi NADH dehydrogenase subunit 1 and cytochrome c oxidase subunit I sequences compared for members of the genus Taenia (Cestoda)
    R B Gasser
    Department of Veterinary Science, The University of Melbourne, Werribee, Victoria, Australia
    Int J Parasitol 29:1965-70. 1999
    ..hydatigena and T. pisiformis (of canids) or T. taeniaeformis (of cats). The NADH dehydrogenase subunit 1 sequence data may prove useful in studies of the systematics and population genetic structure of the Taeniidae...
  79. ncbi The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle
    Peter J Adhihetty
    School of Kinesiology and Health Science, York Univ, Toronto, Ontario, M3J 1P3, Canada
    Am J Physiol Cell Physiol 297:C217-25. 2009
    ....
  80. pmc A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy
    Merei Huigsloot
    Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500HB, Nijmegen, The Netherlands
    Am J Hum Genet 88:488-93. 2011
    ....
  81. pmc Exploring the use of cytochrome oxidase c subunit 1 (COI) for DNA barcoding of free-living marine nematodes
    Sofie Derycke
    Marine Biology Research Group, Department of Biology, Ghent University, Ghent, Belgium
    PLoS ONE 5:e13716. 2010
    ..Therefore, we investigate the amplification and sequencing success of two partitions of the COI gene, the M1-M6 barcoding region and the I3-M11 partition...
  82. ncbi Molecular characterization of Swiss Ceratopogonidae (Diptera) and evaluation of real-time PCR assays for the identification of Culicoides biting midges
    Claudia E Wenk
    Institute of Parasitology, University of Zurich, Winterthurerstr 266a, 8057 Zurich, Switzerland
    Vet Parasitol 184:258-66. 2012
    ..Primers and probes of this study were devised to be suitable for multiplexed assays but these evaluations await to be performed...
  83. ncbi Trypanosoma cruzi I-III in southern Brazil causing individual and mixed infections in humans, sylvatic reservoirs and triatomines
    Nilce Gomes Abolis
    Laboratório de Parasitologia Humana, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringa, Av Colombo 5790, Parana, Brazil
    Acta Trop 120:167-72. 2011
    ..cruzi I. Four isolates from triatomines showed patterns of both T. cruzi I and II, indicating mixed infections. This study contributes to the characterisation of the dynamics of T. cruzi populations in southern Brazil...
  84. ncbi Differentiation of Culicoides obsoletus and Culicoides scoticus (Diptera: Ceratopogonidae) based on mitochondrial cytochrome oxidase subunit I
    N Pages
    Fundació CReSA Entomologia, Universitat Autonoma de Barcelona, Campus de Bellaterra, Spain
    J Med Entomol 42:1026-34. 2005
    ..The species-specific PCR diagnostic was compared with morphological discrimination of C. obsoletus and C. scoticus females. The morphologic characters were not fully reliable...
  85. ncbi Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice
    Natasa Dragicevic
    Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, USA
    J Alzheimers Dis 20:S535-50. 2010
    ..Therapeutics that target this cascade could be beneficial in the treatment of AD...
  86. ncbi Identification of tyrosine-phosphorylated proteins of the mitochondrial oxidative phosphorylation machinery
    O Augereau
    Physiopathologie Mitochondriale, INSERM U688, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Cell Mol Life Sci 62:1478-88. 2005
    ..The tyrosine phosphatase PTP 1B was found in brain but not in muscle, heart or liver mitochondria. Our results suggest that tyrosine kinases and phosphatases are involved in the regulation of oxidative phosphorylation...
  87. pmc Molecular approaches to identify cryptic species and polymorphic species within a complex community of fig wasps
    Jin Hua Xiao
    Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e15067. 2010
    ..e. NUMTs, or the effects of Wolbachia infections. The analyses suggest that combining multiple markers is the best choice for inferring species identifications as any one marker may be unsuitable in a given case...
  88. pmc The brain metabolic enhancer methylene blue improves discrimination learning in rats
    Kathryn M Wrubel
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Pharmacol Biochem Behav 86:712-7. 2007
    ....
  89. pmc Design and applicability of DNA arrays and DNA barcodes in biodiversity monitoring
    Mehrdad Hajibabaei
    Biodiversity Institute of Ontario, Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
    BMC Biol 5:24. 2007
    ..DNA arrays (micro and macro) and DNA barcodes are two molecular approaches that have recently garnered much attention. Here, we compare these two platforms for identification of an important group, the mammals...
  90. ncbi The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schistosoma Weinland, 1858
    A E Lockyer
    Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
    Parasitology 126:203-24. 2003
    ..ocellata and T. szidati, seem to be synonymous. The position of Orientobilharzia within the Schistosoma is confirmed, as is an Asian origin for the Schistosoma, followed by subsequent dispersal through India and Africa...
  91. ncbi Regional brain metabolism with cytochrome c oxidase histochemistry in a PS1/A246E mouse model of autosomal dominant Alzheimer's disease: correlations with behavior and oxidative stress
    Catherine Strazielle
    INSERM, U954, Faculty of Medicine, Vandoeuvre les Nancy, 54500, France
    Neurochem Int 55:806-14. 2009
    ....
  92. pmc Reconstructing mammalian phylogenies: a detailed comparison of the cytochrome B and cytochrome oxidase subunit I mitochondrial genes
    Shanan S Tobe
    Centre for Forensic Science, WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom
    PLoS ONE 5:e14156. 2010
    ..Using a Kimura 2-parameter p-distance (x100) threshold of 1.5-2.5, cyt b gives a better resolution for separating species with a lower false positive rate and higher positive predictive value than those of COI...
  93. ncbi A phylogenetic analysis of filarial nematodes: comparison with the phylogeny of Wolbachia endosymbionts
    M Casiraghi
    Istituto di Patologia Generale Veterinaria, , Italy
    Parasitology 122:93-103. 2001
    ..and Wuchereria spp.) and the sister group relationship of Dirofilaria spp. and Onchocerca spp. However, the placement of the Wolbachia-free filaria Acanthocheilonema viteae is ambiguous and dependent on the phylogenetic methods used...
  94. pmc Identifying Fishes through DNA Barcodes and Microarrays
    Marc Kochzius
    Centre for Applied Gene Sensor Technology, FB2 UFT, University of Bremen, Bremen, Germany
    PLoS ONE 5:e12620. 2010
    ..Species identification is a key problem throughout the life cycle of fishes: from eggs and larvae to adults in fisheries research and control, as well as processed fish products in consumer protection...
  95. ncbi Endurance training and detraining in mitochondrial myopathies due to single large-scale mtDNA deletions
    Tanja Taivassalo
    Department of Kinesiology, McGill University, Montreal, Quebec, Canada
    Brain 129:3391-401. 2006
    ..The effects of detraining clearly implicate physical inactivity as an important mechanism in reducing exercise capacity and quality of life in patients with mitochondrial myopathy...
  96. ncbi Comparative genotyping of Echinococcus granulosus infecting buffalo in Iran using cox1 gene
    Arash Amin Pour
    Department of Parasitology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
    Parasitol Res 108:1229-34. 2011
    ....
  97. pmc Towards a global barcode library for Lymantria (Lepidoptera: Lymantriinae) tussock moths of biosecurity concern
    Jeremy R deWaard
    Forest Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 5:e14280. 2010
    ....
  98. pmc MIR-210 modulates mitochondrial respiration in placenta with preeclampsia
    S Muralimanoharan
    Center for Pregnancy and Newborn Research, Dept of Ob Gyn, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Placenta 33:816-23. 2012
    ..These data collectively suggest that miR-210 overexpression during PE could be responsible for placental mitochondria dysfunction...
  99. ncbi Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase
    C Oswald
    Institute of Genetics, Dresden University of Technology, 01062 Dresden, Germany
    J Mol Biol 389:470-9. 2009
    ..An interdependent assembly scenario for the formation of supercomplexes that rather requires the coordinated synthesis and association of individual complexes, is proposed...
  100. ncbi Taxonomy. Will DNA bar codes breathe life into classification?
    Eliot Marshall
    Science 307:1037. 2005
  101. ncbi Low doses of insulin-like growth factor-I induce mitochondrial protection in aging rats
    Juan E Puche
    Department of Medical Physiology, School of Medicine, University CEU Universidad San Pablo, Boadilla del Monte, 28668, Madrid, Spain
    Endocrinology 149:2620-7. 2008
    ..In conclusion, these results show that the cytoprotective effect of IGF-I is closely related to a mitochondrial protection, leading to reduce free radical production, oxidative damage, and apoptosis, and to increased ATP production...

Research Grants62

  1. Nanoelectrode arrays for study of the molecular mechanisms, triggers, and inhibit
    Peter J Burke; Fiscal Year: 2012
    ..A high throughput technology to monitor P in mitochondria will allow further studies of these issues in cancer biology. ..
  2. Development of an instrument to track oxygen from blood to mitochondria in vivo
    Kenneth A Schenkman; Fiscal Year: 2013
    ..Our long-term goal is to develop the cell oximeter for clinical use in ambulances, emergency departments, intensive care units, and operating rooms. ..
  3. Quantum Chemistry of Proton Pumping by Cytochrome c Oxidases
    Louis Noodleman; Fiscal Year: 2013
    ..Understanding the structures, mechanisms, and functions of mitochondrial CcO's is important for better analysis of many genetic and metabolic diseases and cancers, and is also relevant to pathologies of aging. ..
  4. 3-D CRYSTALLIZATION OF MEMBRANE PROTEINS
    JAMES GOUAUX; Fiscal Year: 1999
    ..Extending the methods elucidated from this research to other systems will provide a structural understanding of such human conditions as cystic fibrosis, retinitis pigmentosa and multidrug resistance. ..
  5. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003
    ..The varied and pertinent expertise of her committee members will make the development phase of her patient-oriented clinical research career a well-rounded and enlightening experience. ..
  6. MOLECULAR GENETICS OF BACILLUS SUBTILIS CYTOCHROME AA3
    Harry Taber; Fiscal Year: 1993
    ....
  7. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..
  8. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  9. Neurochemical Organization of Brain Stem Respiratory Nuclei
    MARGARET TT WONG RILEY; Fiscal Year: 2010
    ....
  10. Proton-coupled electron translocation in metalloenzymes
    ROBERT CUKIER; Fiscal Year: 2006
    ..Contemporaneously, we will explore PTR by simulation methodologies that we are developing, which combine quantum mechanics and molecular dynamics to quantitatively describe proton translocation. ..
  11. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
    ..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
  12. Cytochrome C Oxidase I:A Biomarker for Colon Cancer Risk
    Claire Payne; Fiscal Year: 2006
    ..Various molecular and cellular techniques will be used in these studies. ..
  13. Catalytic Mechanisms of Heme-Copper Oxidases
    Marian Fabian; Fiscal Year: 2005
    ..abstract_text> ..
  14. Role of Subunit III in Cytochrome Oxidase Function
    Jonathan Hosler; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  16. Mouse Models of Mitochondrial Encephalomyopathies
    CARLOS MORAES; Fiscal Year: 2009
    ..We expect these studies to provide evidence that specific defects in the OXPHOS can manifest as distinct phenotypic alterations. ..
  17. OXIDATIVE PHOSPHORYLATION IN CELL GROWTH AND DEATH
    CARLOS TORRES MORAES; Fiscal Year: 2010
    ..abstract_text> ..
  18. Preventive of Bile Acid-Induced Colonic Oxidative DNA Damage
    Claire Margaret Payne; Fiscal Year: 2010
    ..129 mice) developed in our laboratory;2) NOS-/- k.o./DOC mouse model;3) arginine-enhanced colon tumor ApcMin/+ mouse model developed in our laboratory;4) the AOM mouse model of colon carcinogenesis using A/J mice. ..
  19. Molecular mechanism of redox driven proton pumps
    Marian Fabian; Fiscal Year: 2010
    ..Specific aims will be addressed using the purified bovine heart oxidase, enzyme incorporated into phospholipid vesicles and in submitochondrial particles. ..
  20. EXPLORING NUCLEAR-MITOCHONDRIAL DNA INTERACTIONS
    CARLOS MORAES; Fiscal Year: 2004
    ..We will also study some physical and biochemical properties of oocyte mitochondria and test if these specific features are optimized for mitochondrial maintenance in the egg. ..
  21. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  22. PROTEIN TARGETS OF OXIDATIVE DAMAGE DURING AGING
    RAJINDAR SOHAL; Fiscal Year: 2003
    ..abstract_text> ..
  23. Influence of Diet on Mitochondria & Cardiolipin During Heart Failure in SHHF Rats
    GENEVIEVE SPARAGNA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Transmission genetics of mammalian mitochondrial DNA
    Eric Shoubridge; Fiscal Year: 2008
    ..abstract_text> ..
  25. Old Westbury Neuroscience Research Institute MIDARP
    George Stefano; Fiscal Year: 2008
    ..abstract_text> ..
  26. Modulation of ATP synthesis in mitochondrial disorders
    Giovanni Manfredi; Fiscal Year: 2008
    ....
  27. Cortical Representational Plasticity of Oral Structures
    KENNETH CATANIA; Fiscal Year: 2003
    ..abstract_text> ..
  28. Effect of Age on Exercise-Induced Cardioprotection
    JOSEPH STARNES; Fiscal Year: 2003
    ..The results of this Aim will provide key direction for the effective design of further comprehensive studies using inhibitors and/or activators of specific proteins or signaling pathways. ..
  29. Chronic Alcohol and Liver Oxidative Stress
    Shannon Bailey; Fiscal Year: 2003
    ..This investigation should thus provide information on ethanol-elicited alterations that contribute to oxidative damage in the liver. ..
  30. Mitochondrial Function and Aging in S. cerevisiae
    PAUL KIRCHMAN; Fiscal Year: 2003
    ..Results from these experiments will serve to clarify the role of variations in mitochondrial function in determining longevity. ..
  31. Cytochrome Oxidase Polymorphisms in Aging
    Russell Swerdlow; Fiscal Year: 2007
    ..This work could help explain why complex genetic diseases are sometimes associated with mitochondrial dysfunction. ..
  32. In Vivo EPR Imaging of Myocardial Oxygen Consumption
    Guanglong He; Fiscal Year: 2009
    ..Critical information will be obtained regarding the regulatory role of endothelium-derived NO on myocardial oxygen consumption, redox alterations, and postichemic myocardial injury and protection in cardiac physiology and disease. ..
  33. BIOENERGETIC MECHANISMS IN MULTICENTER ENZYMES
    Shelagh Ferguson Miller; Fiscal Year: 2002
    ..For sGC, we will study the molecular mechanisms that allow efficient NO/O2 discrimination and begin work aimed at understanding how NO binding triggers cyclase activity. ..
  34. MOLECULAR GENETICS OF MAMMALIAN CYTOCHROME C OXIDASE
    Lawrence Grossman; Fiscal Year: 2001
    ....
  35. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN DOUGLAS ALLOWAY; Fiscal Year: 2010
    ....
  36. Oral Yeast Carriage and Salivary Antifungal Activity
    EVA HELMERHORST; Fiscal Year: 2008
    ..The experiments outlined here will provide the basis for a better understanding of antifungal mechanisms exerted by saliva in the oral cavity. [unreadable] [unreadable] [unreadable]..
  37. INDUCTION AND BIOGENESIS OF SUBCELLULAR ORGANELLES
    Samuel Kaplan; Fiscal Year: 2008
    ..It is likely, that these studies will serve as a guide to the potential role of the electron transport chain in gene regulation in higher organisms. ..
  38. IGF-1 in neocortical development and plasticity
    David Riddle; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  39. IGF-1 Receptor Signaling in Mammary Gland Development
    Darryl Hadsell; Fiscal Year: 2006
    ..abstract_text> ..
  40. Oxidants, Mitochondria,and Renal Ischemia/Reperfusion
    LEE MACMILLAN CROW; Fiscal Year: 2005
    ..This information will be helpful in determining possible therapeutic interventions for improving current techniques in renal preservation and transplantation. ..
  41. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2004
    ..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..
  42. ANTIESTROGEN-RECEPTOR INTERACTION WITH DNA
    Russell Hilf; Fiscal Year: 2005
    ..Overall, the plan is to determine how the ERa and ERb subtypes interact with natural EREs, various ligands, and with each other to regulate gene expression." ..
  43. Pathogenesis of a Novel Limb-Girdle Muscular Dystrophy
    Michio Hirano; Fiscal Year: 2003
    ..For the patients, achieving the proposed goals will allow more accurate prenatal diagnosis, genetic counseling, and perhaps contribute to more rational therapies in the future. ..
  44. Improving Bayesian Phylogeny
    Bret Larget; Fiscal Year: 2006
    ..abstract_text> ..
  45. Attentional Regulation of Plasticity in Auditory Cortex
    Daniel Polley; Fiscal Year: 2004
    ..abstract_text> ..
  46. DESIGN, SYNTHESIS AND STUDY OF NEW SENSITIZERS FOR PDT
    MICHAEL DETTY; Fiscal Year: 2004
    ....
  47. Functional organization of auditory corticothalamic projection systems
    Daniel Llano; Fiscal Year: 2007
    ..It is hoped that this work will lead to a better understanding of speech perception and to new ways to diagnose and treat patients who have lost their ability to use language. [unreadable] [unreadable] [unreadable]..
  48. Development and Improvement of an Animal Resource Core
    Dale Bredesen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. Population genetic structure and bionomics of Anopheles lesteri in China
    Yajun Ma; Fiscal Year: 2007
    ..lesteri mosquitoes as well as the geographic variation of its bionomics. This information is particularly useful for the design of rational area-specific vector control methods. [unreadable] [unreadable]..
  50. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2008
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..
  51. Center for Integrative Studies of Aging
    Dale Bredesen; Fiscal Year: 2004
    ....
  52. Lung Metabolism: Multiple Indicator Dilution
    Said H Audi; Fiscal Year: 2010
    ..Such results will provide targets for future mechanistic studies designed to evaluate the utility of the differentially altered redox enzymes as potential therapeutic targets for protection from O2 toxicity. ..
  53. Genetic analysis of Htr2c RNA editing in amygdala
    DAVID AIREY; Fiscal Year: 2008
    ..The brain region of investigation is the amygdala, which is rich in serotonin 2C receptors and plays important roles in anxiety disorders and depression. [unreadable] [unreadable]..
  54. Functional Organization of Somatosensory Cortex
    KEVIN ALLOWAY; Fiscal Year: 2007
    ..To address this issue, conditional cross-correlation analysis will be used to quantify the impact of synchronized activity in SI on the probability of neuronal responsiveness in corresponding parts of the MI whisker representation. ..
  55. PINEAL OPIOID RECEPTORS & ANALGESIC ACTION OF MELATONIN
    Manuchair Ebadi; Fiscal Year: 2002
    ..Therefore, future research must synthesize highly efficacious melatonin analogues capable of providing maximum analgesia and hopefully being devoid of addiction liability now associated with currently available narcotics. ..
  56. The organization and plasticity of cortical areas representing the dentition
    KENNETH CATANIA; Fiscal Year: 2009
    ..The long-term goal of these experiments is to identify general principles of brain organization and plasticity. ..