serum amyloid a protein

Summary

Summary: An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.

Top Publications

  1. ncbi Polymorphisms in the SAA1 gene are associated with ankle-to-brachial index in Han Chinese healthy subjects
    Xiang Xie
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P R China
    Blood Press 20:232-8. 2011
  2. ncbi C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
  3. pmc Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes
    R Badolato
    Laboratory of Molecular Immunoregulation, Program Resources, Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    J Exp Med 180:203-9. 1994
  4. pmc Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function
    R L Meek
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 91:3186-90. 1994
  5. pmc Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease
    Steven Bozinovski
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia 3010
    Proc Natl Acad Sci U S A 109:935-40. 2012
  6. pmc Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients
    Brandon L Pierce
    Fred Hutchinson Cancer Center, Cancer Prevention Research Program, 1100 Fairview Ave N, M4 B402, Seattle WA 98109 1024, USA
    J Clin Oncol 27:3437-44. 2009
  7. pmc Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey
    Xiang Xie
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
    PLoS ONE 5:e13997. 2010
  8. ncbi Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states
    S Urieli-Shoval
    Hematology Unit, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    Curr Opin Hematol 7:64-9. 2000
  9. ncbi Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway
    Katri Niemi
    Wihuri Research Institute, 00140 Helsinki, Finland
    J Immunol 186:6119-28. 2011
  10. pmc Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice
    Jennifer L Ather
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 187:64-73. 2011

Detail Information

Publications314 found, 100 shown here

  1. ncbi Polymorphisms in the SAA1 gene are associated with ankle-to-brachial index in Han Chinese healthy subjects
    Xiang Xie
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P R China
    Blood Press 20:232-8. 2011
    OBJECTIVE. Recent study suggested that the genetic polymorphisms of serum amyloid A protein (SAA) were linked to cardiovascular disease (CVD)...
  2. ncbi C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    ..Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events...
  3. pmc Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes
    R Badolato
    Laboratory of Molecular Immunoregulation, Program Resources, Inc DynCorp, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    J Exp Med 180:203-9. 1994
    ..On the basis of these data, we suggest that SAA may participate in enhancing the migration of monocytes and PMN to inflamed tissues during an acute phase response...
  4. pmc Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function
    R L Meek
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 91:3186-90. 1994
    ..Furthermore, expression of SAAs by endothelial cells is compatible with the evidence that SAA modulates platelet aggregation and function and possibly adhesion at the endothelial cell surface...
  5. pmc Serum amyloid A opposes lipoxin A₄ to mediate glucocorticoid refractory lung inflammation in chronic obstructive pulmonary disease
    Steven Bozinovski
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia 3010
    Proc Natl Acad Sci U S A 109:935-40. 2012
    ..Taken together, these findings identify SAA as a therapeutic target for inhibition and implicate SAA as a mediator of GC-resistant lung inflammation that can overwhelm organ protective signaling by lipoxins at ALX/FPR2 receptors...
  6. pmc Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients
    Brandon L Pierce
    Fred Hutchinson Cancer Center, Cancer Prevention Research Program, 1100 Fairview Ave N, M4 B402, Seattle WA 98109 1024, USA
    J Clin Oncol 27:3437-44. 2009
    ..04; CRP P trend = .07). CONCLUSION Circulating SAA and CRP may be important prognostic markers for long-term survival in breast cancer patients, independent of race, tumor stage, and body mass index...
  7. pmc Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey
    Xiang Xie
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
    PLoS ONE 5:e13997. 2010
    b>Serum amyloid A protein (SAA) is not only an inflammatory factor, but also an apolipoprotein that can replace apolipoprotein A1 (apoA1) as the major apolipoprotein of high-density lipoprotein (HDL), which has been linked to ..
  8. ncbi Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states
    S Urieli-Shoval
    Hematology Unit, Hadassah University Hospital, Mount Scopus, Jerusalem, Israel
    Curr Opin Hematol 7:64-9. 2000
    ..In addition, recent experiments suggest that SAA may play a "housekeeping" role in normal human tissues...
  9. ncbi Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway
    Katri Niemi
    Wihuri Research Institute, 00140 Helsinki, Finland
    J Immunol 186:6119-28. 2011
    ..Furthermore, the SAA-induced secretion of active cathepsin B may lead to extracellular processing of SAA and, thus, potentially to the development of amyloid A amyloidosis...
  10. pmc Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice
    Jennifer L Ather
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 187:64-73. 2011
    ....
  11. ncbi Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
    B Delia Johnson
    Graduate School of Public Health, University of Pittsburgh, Parran 127, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Circulation 109:726-32. 2004
    ..However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear...
  12. pmc A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
    S B Su
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Exp Med 189:395-402. 1999
    ..In contrast, SAA was not a ligand or agonist for FPR, the high affinity fMLP receptor. Thus, SAA is the first chemotactic ligand identified for FPRL1. Our results suggest that FPRL1 mediates phagocyte migration in response to SAA...
  13. ncbi Promoting export of macrophage cholesterol: the physiological role of a major acute-phase protein, serum amyloid A 2.1
    Shui Pang Tam
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada K7L 3N6
    J Lipid Res 43:1410-20. 2002
    ....
  14. ncbi Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein
    A S Whitehead
    Department of Immunology, Children s Hospital, Boston, Massachusetts
    J Biol Chem 267:3862-7. 1992
    A novel serum amyloid A protein (SAA) has been identified as a normal apolipoprotein component of non-acute phase high density lipoprotein...
  15. ncbi The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    Sachie Hiratsuka
    Department of Pharmacology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Nat Cell Biol 10:1349-55. 2008
    ..Thus, blocking SAA3-TLR4 function in the pre-metastatic phase could prove to be an effective strategy for the prevention of pulmonary metastasis...
  16. pmc Serum amyloid A3 does not contribute to circulating SAA levels
    Tsuyoshi Chiba
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Lipid Res 50:1353-62. 2009
    ..In contrast, SAA3 could be detected in medium from cultured adipocytes. Our findings indicate that the expression of SAA3 in adipose tissue is upregulated by obesity, but it does not contribute to the circulating pool of SAA in mice...
  17. pmc Serum uric acid levels are associated with polymorphism in the SAA1 gene in Chinese subjects
    Xiang Xie
    Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, People s Republic of China
    PLoS ONE 7:e40263. 2012
    Serum uric acid (SUA) is a cardiovascular risk marker associated with inflammation. The serum amyloid A protein (SAA) is an inflammatory factor and is associated with cardiovascular disease (CVD)...
  18. pmc Serum amyloid A regulates granulomatous inflammation in sarcoidosis through Toll-like receptor-2
    Edward S Chen
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 181:360-73. 2010
    ....
  19. pmc Cutting edge: TLR2 is a functional receptor for acute-phase serum amyloid A
    Ni Cheng
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 181:22-6. 2008
    ..Selective reduction of SAA-induced gene expression was observed in tlr2-/- mouse macrophages compared with wild-type cells. These results suggest a potential role for SAA in inflammatory diseases through activation of TLR2...
  20. ncbi Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion
    Chang Yeop Han
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    Diabetes 56:2260-73. 2007
    ..We hypothesize that adipocyte hypertrophy leads to increased production of SAA and hyaluronan, which act in concert to recruit and retain monocytes, thereby leading to local inflammation in adipose tissue...
  21. ncbi Serum amyloid A induces IL-8 secretion through a G protein-coupled receptor, FPRL1/LXA4R
    Rong He
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago 60012, USA
    Blood 101:1572-81. 2003
    ..The ability of FPRL1/LXA4R to mediate 2 drastically different and opposite functions suggests that it plays a role in the modulation of inflammatory and immune responses...
  22. ncbi The acute-phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein
    Paul K Witting
    Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia
    Free Radic Biol Med 51:1390-8. 2011
    ..The relative HDL to SAA concentrations may regulate the proatherogenic properties of SAA on the vascular endothelium...
  23. ncbi Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy
    Mary Connolly
    St Vincent s University Hospital, Dublin Academic Medical Centre, The Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
    Arthritis Rheum 64:1035-45. 2012
    ..To investigate the relationship between acute-phase serum amyloid A (A-SAA) and joint destruction in inflammatory arthritis...
  24. ncbi Serum amyloid A-induced mRNA expression and release of tumor necrosis factor-alpha (TNF-alpha) in human neutrophils
    Elaine Hatanaka
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Sao Paulo, SP CEP 05508 900, Brazil
    Immunol Lett 91:33-7. 2004
    ..These data are congruent with the increasing evidence of the role of SAA in modulating inflammatory and immune responses, possibly contributing to the pool of cytokines produced in acute inflammation and in chronic diseases...
  25. ncbi Hyperglycemia-induced production of acute phase reactants in adipose tissue
    Y Lin
    Department of Cell Biology, Department of Medicine, and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 276:42077-83. 2001
    ..Adipose tissue may therefore play a major role in the pathogenic sequelae of Type II diabetes, in particular the cardiovascular problems associated with prolonged hyperglycemia...
  26. ncbi Serum amyloid A stimulates matrix-metalloproteinase-9 upregulation via formyl peptide receptor like-1-mediated signaling in human monocytic cells
    Ha Young Lee
    Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong A University, Busan 602 714, Republic of Korea
    Biochem Biophys Res Commun 330:989-98. 2005
    ..Taken together, we suggest that SAA plays a role in the modulation of inflammatory and immune responses via FPRL1, by inducing MMP-9 upregulation in human monocytic cells...
  27. ncbi Serum amyloid A induction of cytokines in monocytes/macrophages and lymphocytes
    Changjie Song
    Department of Cardiology and ANZAC Research Institute Vascular Biology Group, Concord Hospital, University of Sydney, Sydney, Australia
    Atherosclerosis 207:374-83. 2009
    ..This study explored SAA-induced cytokine production and secretion by mononuclear cells...
  28. ncbi Serum amyloid A: a marker of adiposity-induced low-grade inflammation but not of metabolic status
    Christine Poitou
    INSERM U755, Paris, France
    Obesity (Silver Spring) 14:309-18. 2006
    ..We studied the variations of expression of the SAA gene in adipose and liver tissues and of SAA serum levels, as well as their relationships with metabolic features during weight loss...
  29. ncbi HDL cholesterol transport during inflammation
    Deneys R van der Westhuyzen
    Department of Internal Medicine, Cardiovascular Research Center and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky, USA
    Curr Opin Lipidol 18:147-51. 2007
    ....
  30. ncbi Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition
    C Poitou
    Department of Nutrition and Biochemistry, French Institute of Health and Medical Research Avenir, EA 3502, Paris VI University, Hotel Dieu Hospital, Paris, France
    Diabetologia 48:519-28. 2005
    ..In the present study a series of histopathological, cellular and gene expression studies was performed to assess the importance of SAA in common obesity and its possible production by mature adipocytes...
  31. ncbi Erythrocyte sedimentation rate, C-reactive protein level, and serum amyloid a protein for patient selection and monitoring of anti-tumor necrosis factor treatment in ankylosing spondylitis
    Mirjam K de Vries
    VU University Medical Centre, Amsterdam, The Netherlands
    Arthritis Rheum 61:1484-90. 2009
    ....
  32. ncbi Natural history and outcome in systemic AA amyloidosis
    Helen J Lachmann
    National Amyloidosis Centre and Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London
    N Engl J Med 356:2361-71. 2007
    Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders...
  33. ncbi IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system
    Keisuke Hagihara
    Department of Medical Science I, School of Health and Sport Sciences, Osaka University, Osaka, Japan
    Biochem Biophys Res Commun 314:363-9. 2004
    ..We were able to demonstrate that IL-6 plays a critical role in the synergistic induction of human SAA gene when stimulated with proinflammatory cytokines...
  34. pmc Acute phase protein response in an experimental model of ovine caseous lymphadenitis
    Peter D Eckersall
    Division of Animal Production and Public Health, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Rd, Glasgow, G61 1QH, UK
    BMC Vet Res 3:35. 2007
    ..The concentration of Hp in serum increases in experimental CLA but it is not known if SAA and AGP respond in parallel or have differing response profiles...
  35. ncbi Why working with porcine circulating serum amyloid A is a pig of a job
    L Soler
    Department of Animal Medicine and Surgery, University of Murcia, 30100 Espinardo, Murcia, Spain
    J Theor Biol 317:119-25. 2013
    ..It is concluded that pig systemic SAA is unique compared to other species, which raises questions about the proposed importance of acute phase SAA in HDL metabolism during inflammation in this species...
  36. ncbi Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I
    Deneys R van der Westhuyzen
    Department of Internal Medicine, Graduate Center for Nutrition Sciences, University of Kentucky Medical Center, Lexington, Kentucky 40536 0200, USA
    J Biol Chem 280:35890-5. 2005
    ..We conclude that the acute phase protein SAA plays an important role in HDL cholesterol metabolism by promoting cellular cholesterol efflux through a number of different efflux pathways...
  37. ncbi Structure of the murine serum amyloid A gene family. Gene conversion
    C A Lowell
    J Biol Chem 261:8442-52. 1986
    ..Comparison of the upstream regions of the SAA genes with those of the rat fibrinogen genes, whose expression is also induced by inflammation, reveals sequences common to all six genes which are very improbable on a random basis...
  38. ncbi Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway
    Ronan H Mullan
    Dept of Rheumatology, Education and Research Centre, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Arthritis Rheum 54:105-14. 2006
    ..To examine the role of the acute-phase protein serum amyloid A (A-SAA) in regulating cell adhesion molecule expression, leukocyte recruitment, and angiogenesis in rheumatoid arthritis (RA)...
  39. ncbi Serum amyloid A isoforms in serum and synovial fluid from spontaneously diseased dogs with joint diseases or other conditions
    Mads Kjelgaard-Hansen
    Central Laboratory, Department of Small Animal Clinical Sciences, Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 3, DK 1870 Frederiksberg, Denmark
    Vet Immunol Immunopathol 117:296-301. 2007
    ..In synovial fluid from inflamed joints one or more highly alkaline SAA isoforms (with apparent isoelectric points above 9.3) were identified, with data suggesting local production of these isoforms in the canine inflamed joint...
  40. ncbi Proinflammatory cytokines but not acute phase serum amyloid A or C-reactive protein, downregulate paraoxonase 1 (PON1) expression by HepG2 cells
    Yoshitaka Kumon
    Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
    Amyloid 9:160-4. 2002
    ..These findings suggested that the decrease in serum PON activity after abdominal surgery in our previous clinical study may be ascribed to a decrease in steady state PON1 mRNA expression by liver with proinflammatory cytokines...
  41. ncbi Kinetics of local and systemic isoforms of serum amyloid A in bovine mastitic milk
    S Jacobsen
    Department of Clinical Studies, Large Animal Surgery, Royal Veterinary and Agricultural University, Dyrlaegevej 48, DK 1870 Frederiksberg C, Copenhagen, Denmark
    Vet Immunol Immunopathol 104:21-31. 2005
    ....
  42. ncbi Tanis: a link between type 2 diabetes and inflammation?
    Ken Walder
    Metabolic Research Unit, School of Health Sciences, Deakin University, Waurn Ponds, Victoria, Australia
    Diabetes 51:1859-66. 2002
    ....
  43. ncbi Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family
    M C De Beer
    Department of Biochemistry, University of Kentucky Medical Center, Lexington, Kentucky, 40536, USA
    Genomics 34:139-42. 1996
    ..These data promote our understanding of the evolution of the Saa family. They enhance our ability to develop the mouse as a transgenic and gene deletion model to advance the understanding of the function of these apolipoproteins...
  44. ncbi Identification and validation of SAA as a potential lung cancer biomarker and its involvement in metastatic pathogenesis of lung cancer
    Hye Jin Sung
    Department of Biochemistry, School of Dentistry and Brain Korea 21, Kyungpook National University and ProtAnBio, Daegu, South Korea
    J Proteome Res 10:1383-95. 2011
    ..Our data suggest that a higher concentration of SAA can serve as an indicator of lung adenocarcinoma and represents a therapeutic target for the inhibition of lung cancer metastasis...
  45. ncbi Abdominal fat mass is associated with adaptive immune activation: the CODAM Study
    Marielle M Thewissen
    Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Obesity (Silver Spring) 19:1690-8. 2011
    ..We conclude that abdominal obesity is associated with systemic adaptive immune activation and that innate immune activation and IR constitute independent and equally important pathways explaining this association...
  46. ncbi Association between serum amyloid A proteins and coronary artery disease: evidence from two distinct arteriosclerotic processes
    A I Fyfe
    Department of Medicine, Molecular Biology Institute, UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 96:2914-9. 1997
    ..Elevations of SAA have been reported in unstable coronary syndromes, but the levels and types of SAA protein in humans with spontaneous or transplant-associated coronary artery disease are not known...
  47. ncbi Serum amyloid A-induced IL-6 production by rheumatoid synoviocytes
    Tomohiro Koga
    Clinical Research Center and Department of Rheumatology, NHO Nagasaki Medical Center, Omura, Japan
    FEBS Lett 582:579-85. 2008
    In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)...
  48. pmc Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice
    Savitha Subramanian
    Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Arterioscler Thromb Vasc Biol 28:685-91. 2008
    ..This study was undertaken to determine whether dietary cholesterol and obesity have additive effects on inflammation and atherosclerosis...
  49. ncbi Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes
    Javier Conde
    Correspondence to Dr Oreste Gualillo, Santiago University Clinical Hospital, Research Laboratory 9 NEIRID LAB, Laboratory of Neuro Endocrine Interactions in Rheumatology and Inflammatory Diseases Building C, Level 2, Calle Choupana s n, 15706, Santiago de Compostela, Spain
    Ann Rheum Dis 70:551-9. 2011
    ..Recently, it has been demonstrated that adipose tissue might contribute to degenerative joint diseases via the secretion of potent bioactive molecules termed adipokines...
  50. ncbi Serum amyloid A enhances plasminogen activation: implication for a role in colon cancer
    Amit Michaeli
    Hematology Unit, Hadassah Hebrew University Medical Center, Mount Scopus, 91240 Jerusalem, Israel
    Biochem Biophys Res Commun 368:368-73. 2008
    ..Together, the data indicate that SAA enhances plasminogen activation and suggest its possible role in plasmin(ogen)-mediated colon cancer progression...
  51. ncbi Local expression of acute phase serum amyloid A mRNA in rheumatoid arthritis synovial tissue and cells
    Y Kumon
    2nd Department of Internal Medicine, Kochi Medical School, Japan
    J Rheumatol 26:785-90. 1999
    ....
  52. ncbi Serum amyloid A is a chemotactic agonist at FPR2, a low-affinity N-formylpeptide receptor on mouse neutrophils
    T S Liang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 270:331-5. 2000
    ..Our results suggest that FPR2 specifically mediates mouse neutrophil migration in response to SAA...
  53. ncbi Significance of SAA1.3 allele genotype in Japanese patients with amyloidosis secondary to rheumatoid arthritis
    T Nakamura
    Section of Internal Medicine and Rheumatology, Kumamoto Center for Arthritis and Rheumatology, 1 15 7 Kuhonji, Kumamoto 862 0976, Japan
    Rheumatology (Oxford) 45:43-9. 2006
    ..To clarify the clinical significance of the SAA1.3 allele in the development and outcome of AA amyloidosis in Japanese patients with rheumatoid arthritis (RA)...
  54. pmc CD36 is a novel serum amyloid A (SAA) receptor mediating SAA binding and SAA-induced signaling in human and rodent cells
    Irina N Baranova
    Department of Laboratory Medicine, Clinical Center, NICHD, National Institutes of Health, Bethesda, Maryland, USA
    J Biol Chem 285:8492-506. 2010
    ..These observations indicate that CD36 is a receptor mediating SAA binding and SAA-induced pro-inflammatory cytokine secretion predominantly through JNK- and ERK1/2-mediated signaling...
  55. ncbi The acute-phase response and serum amyloid A inhibit the inflammatory response to Acinetobacter baumannii Pneumonia
    Rosemarijn Renckens
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 193:187-95. 2006
    ..Acinetobacter baumannii is an emerging pathogen in nosocomial pneumonia. Trauma and postsurgical patients display a profound acute-phase protein response and are susceptible to pneumonia...
  56. ncbi Discovery and identification of Serum Amyloid A protein elevated in lung cancer serum
    SongWei Dai
    Key Laboratory of Cell Proliferation and Regulation of Ministry of Education, Beijing Normal University, Beijing, 100875, China
    Sci China C Life Sci 50:305-11. 2007
    ..gel electrophoresis by matching the molecular weight with peaks on WCX2 chips and was identified as Serum Amyloid A protein (SAA) by MALDI/MS-MS and database searching...
  57. ncbi High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes in the MIRACL study
    Scott Kinlay
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis St, Boston, Mass 02115, USA
    Circulation 108:1560-6. 2003
    ..Although statins reduce inflammatory markers in asymptomatic adults or in patients with stable angina, the effect of statins on the markedly heightened inflammation in patients with acute coronary syndromes is unknown...
  58. ncbi Is serum amyloid A an endogenous TLR4 agonist?
    Silvana Sandri
    Department of Clinical Analysis and Toxicology, Faculty of Pharmaceutical Sciences, Biomedical Science Institute, University of Sao Paulo, Sao Paulo, SP, Brazil
    J Leukoc Biol 83:1174-80. 2008
    ..In conclusion, our study makes a novel observation that SAA might be an endogenous agonist for the TLR4 complex on macrophages. The contribution of this finding in amplifying innate immunity during the inflammatory process is discussed...
  59. ncbi Serum amyloid a is a biomarker of acute exacerbations of chronic obstructive pulmonary disease
    Steven Bozinovski
    Department of Pharmacology, Medical Building Level 8, University of Melbourne, Parkville, 3010 Australia
    Am J Respir Crit Care Med 177:269-78. 2008
    ..Serum amyloid A (SAA) is a novel candidate exacerbation biomarker identified by proteomic screening...
  60. pmc Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A
    Carmela De Santo
    Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
    Nat Immunol 11:1039-46. 2010
    ....
  61. ncbi Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases
    Irina N Baranova
    Department of Laboratory Medicine, W G Magnuson Clinical Center, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 280:8031-40. 2005
    b>Serum amyloid A protein (SAA) is an acute-phase reactant, known to mediate pro-inflammatory cellular responses...
  62. ncbi Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period
    Bas C van Bussel
    Department of Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Hypertension 58:588-95. 2011
    ..This provides evidence that arterial stiffening may be a mechanism through which endothelial dysfunction and low-grade inflammation lead to cardiovascular disease...
  63. pmc Intestinal epithelial serum amyloid A modulates bacterial growth in vitro and pro-inflammatory responses in mouse experimental colitis
    Erik R M Eckhardt
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    BMC Gastroenterol 10:133. 2010
    ....
  64. pmc Intestine may be a major site of action for the apoA-I mimetic peptide 4F whether administered subcutaneously or orally
    Mohamad Navab
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Lipid Res 52:1200-10. 2011
    ..We conclude: i) the dose of 4F administered and not the plasma level achieved determines efficacy; ii) the intestine may be a major site of action for the peptide regardless of the route of administration...
  65. pmc Uremia alters HDL composition and function
    Michael Holzer
    Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Universitatsplatz 4, 8010 Graz, Austria
    J Am Soc Nephrol 22:1631-41. 2011
    ..Assessing HDL composition and function in renal disease may help identify patients at increased risk for cardiovascular disease...
  66. ncbi Serum amyloid A (SAA): a concise review of biology, assay methods and clinical usefulness
    T Yamada
    Department of Clinical Pathology, Jichi Medical School, Minamikawachi, Tochigi, Japan
    Clin Chem Lab Med 37:381-8. 1999
    ..In viral infection and kidney allograft rejection, SAA proved more useful than CRP. Development of convenient assay methods for SAA will facilitate its use in clinical laboratories...
  67. ncbi Serum amyloid A in atherosclerosis
    Victoria L King
    Division of Cardiovascular Medicine, Lexington, Kentucky, USA
    Curr Opin Lipidol 22:302-7. 2011
    ....
  68. ncbi Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment triage in biodosimetry applications
    Natalia I Ossetrova
    AFRRI, SRD, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Health Phys 98:204-8. 2010
    ....
  69. ncbi Serum amyloid A is a better predictor of clinical outcomes than C-reactive protein in non-ST-segment elevation acute coronary syndromes
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    Circ J 71:186-90. 2007
    ....
  70. pmc Defective inflammatory response in interleukin 6-deficient mice
    E Fattori
    Istituto di Ricerche di Biologia Molecolare IRBM P Angeletti, Pomezia, Roma
    J Exp Med 180:1243-50. 1994
    ..Our results reinforce the idea that different patterns of cytokines are involved in systemic and localized tissue damage, and identify IL-6 as an essential mediator of the inflammatory response to localized inflammation...
  71. ncbi Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts
    K Migita
    First Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Lab Invest 78:535-9. 1998
    ..Our data indicate that SAA is a potent inducer of MMPs in the RA synovium and may play a critical role in the degradation of extracellular matrix in the rheumatoid joint...
  72. pmc Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota
    Christopher S Reigstad
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e5842. 2009
    ..6+/-0.1-fold, respectively). Our data suggest that LPS, and potentially other products of the indigenous gut microbiota, might elevate cytokine expression in tissues and thus exacerbate chronic low-grade inflammation observed in obesity...
  73. ncbi Characterization of constitutive human serum amyloid A protein (SAA4) as an apolipoprotein
    M C De Beer
    Department of Biochemistry, University of Kentucky, Lexington, USA
    J Lipid Res 36:526-34. 1995
    ..Using two-dimensional electrophoresis and phosphorimaging, SAA4 was found to be associated with a specific subpopulation of only three HDL particles, not involved in the initial cholesterol transfer from cells...
  74. ncbi Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 98:839-44. 1998
    ..We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and whether randomized treatment with pravastatin reduces that risk...
  75. ncbi Local expression of the serum amyloid A and formyl peptide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis
    Rosemary O'Hara
    St Vincent s University Hospital, Dublin, Ireland
    Arthritis Rheum 50:1788-99. 2004
    ....
  76. ncbi Serum amyloid A is a ligand for scavenger receptor class B type I and inhibits high density lipoprotein binding and selective lipid uptake
    Lei Cai
    Department of Internal Medicine, Graduate Center for Nutritional Sciences, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Biol Chem 280:2954-61. 2005
    ....
  77. ncbi Serum amyloid A binding to formyl peptide receptor-like 1 induces synovial hyperplasia and angiogenesis
    Mi Sook Lee
    Division of Molecular Life Sciences, Pohang University of Science and Technology, Pohang, Korea
    J Immunol 177:5585-94. 2006
    ..These observations indicate that the binding of SAA to FPRL1 may contribute to the destruction of bone and cartilage via the promotion of synoviocyte hyperplasia and angiogenesis, thus providing a potential target for the control of RA...
  78. ncbi Clinical utility of serum amyloid A and macrophage migration inhibitory factor as serum biomarkers for the detection of nonsmall cell lung carcinoma
    Nayela Khan
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 101:379-84. 2004
    ..In the current pilot study, the authors evaluated two overexpressed proteins in lung carcinoma, serum amyloid A (SAA) and macrophage migration inhibitory factor (MIF), as potential diagnostic serum biomarkers for this malignancy...
  79. ncbi Serum amyloid A protein levels as a possible aid in the diagnosis of acute appendicitis in children
    Lilia Lycopoulou
    First Department of Pediatrics, Athens University, Athens, Greece
    Clin Chem Lab Med 43:49-53. 2005
    ..The objective of our study was to evaluate serum amyloid A protein (SAA) levels in children with confirmed acute appendicitis and to compare the sensitivity and specificity ..
  80. ncbi [Secondary amyloidosis with irreversible acute renal failure caused by visceral leishmaniasis in a patient with AIDS]
    M Navarro
    Servicio de Nefrologia, Hospital Universitario Germans Trias i Pujol, Ctra del Canyet s n, 08916 Badalona, Barcelona
    Nefrologia 26:745-6. 2006
    ..Renal biopsy showed glomerular AA amyloid deposits. This is the first case described in humans of secondary amyloidosis caused by visceral leishmaniasis...
  81. ncbi SAA1 gene polymorphisms and the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis
    Junya Ajiro
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Mod Rheumatol 16:294-9. 2006
    ..Both C-13T and C2995T were associated with the development of amyloidosis. Examining both polymorphisms may be more useful than examining only one of them for estimating the risk of the development of amyloidosis...
  82. pmc mRNA expression and release of interleukin-8 induced by serum amyloid A in neutrophils and monocytes
    Fernanda Pereira Ribeiro
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, São Paulo CEP 05508 900, SP, Brazil
    Mediators Inflamm 12:173-8. 2003
    ..In conclusion, SAA appears to be an important mediator of the inflammatory process, possibly contributing to the pool of IL-8 produced in chronic diseases, which may play a role in degenerative diseases...
  83. ncbi Serum amyloid A is an activator of PMN antimicrobial functions: induction of degranulation, phagocytosis, and enhancement of anti-Candida activity
    R Badolato
    Clinica Pediatrica, Universita di Brescia, Italy
    J Leukoc Biol 67:381-6. 2000
    ....
  84. ncbi Serum amyloid A induces CCL20 secretion in mononuclear cells through MAPK (p38 and ERK1/2) signaling pathways
    Silvana Sandri
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, São Paulo CEP 05508 900, Brazil
    Immunol Lett 121:22-6. 2008
    ..Our results point to SAA as an important link of innate to adaptive immunity, once it might act on the recruitment of mononuclear cells...
  85. pmc Serum amyloid A induces reactive oxygen species (ROS) production and proliferation of fibroblast
    E Hatanaka
    Instituto de Ciências da Atividade Física e Esportes, Universidade Cruzeiro do Sul, Sao Paulo, Brazil
    Clin Exp Immunol 163:362-7. 2011
    ..These findings support the notion that, in chronic inflammatory sites, SAA activated fibroblast proliferation and ROS production...
  86. ncbi Inflammation-responsive transcription factor SAF-1 activity is linked to the development of amyloid A amyloidosis
    Alpana Ray
    Department of Veterinary Pathobiology, University of Missouri, 126A Connaway Hall, Columbia, MO 65211, USA
    J Immunol 177:2601-9. 2006
    ..Together, these results provide direct evidence that SAF-1 plays a key role in the development of AA amyloidosis, a consequence of chronic inflammation...
  87. ncbi Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments
    Tadashi Nakamura
    Internal Medicine and Rheumatology, Kumamoto Center for Arthritis and Rheumatology, 1 15 7 Kuhonji, Kumamoto 862 0976, Japan
    Clin Exp Rheumatol 29:850-7. 2011
    ..These AA amyloid fibrils derive from the circulatory acute-phase reactant serum amyloid A protein (SAA), and may be controlled by treatment...
  88. pmc Expression of serum amyloid a in human ovarian epithelial tumors: implication for a role in ovarian tumorigenesis
    Simcha Urieli-Shoval
    Hematology Unit, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem 91240, Israel
    J Histochem Cytochem 58:1015-23. 2010
    ..Enhanced expression of SAA in ovarian carcinomas may play a role in ovarian tumorigenesis and may have therapeutic application...
  89. ncbi Could antibodies against serum amyloid A function as physiological regulators in humans?
    Katja Lakota
    Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia
    Autoimmunity 44:149-58. 2011
    ..7 μg/ml (97.5th percentile). Significantly, higher concentrations of SAA were observed for antiphospholipid syndrome, rheumatoid arthritic, and SLE patients...
  90. ncbi Serum amyloid A has antiviral activity against hepatitis C virus by inhibiting virus entry in a cell culture system
    Muriel Lavie
    Hepatitis C Laboratory, CNRS Institut de Biologie de Lille UMR8161 and Institut Pasteur de Lille, Lille, France
    Hepatology 44:1626-34. 2006
    ..In conclusion, our data demonstrate an antiviral activity for SAA and suggest a tight relationship between SAA and HDL in modulating HCV infectivity...
  91. pmc The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury
    Christian Klein
    Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
    J Clin Invest 115:860-9. 2005
    ..Additionally, we identified the IL-6-gp130-STAT3-dependent proteins KC and SAA2 as new candidates for therapeutic targets in liver diseases...
  92. ncbi Docosahexaenoic acid regulates serum amyloid A protein to promote lipolysis through down regulation of perilipin
    Ya C Wang
    Department of Animal Science and Technology Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
    J Nutr Biochem 21:317-24. 2010
    ..DHA also enhances the expression of serum amyloid A protein (SAA), a possible lipid metabolism related gene...
  93. ncbi IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction
    Dorothée Missé
    Research Institute for Development, Laboratory of Retroviral and Molecular Immunology, Montpellier, France
    J Immunol 178:407-15. 2007
    ..Taken together, these results suggest new correlates of EU protection and identify a cascade involving IL-22 and the acute phase protein pathway that is associated with innate host resistance to HIV infection...
  94. ncbi The acute phase protein serum amyloid A primes neutrophils
    Elaine Hatanaka
    Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, CEP 05508 900, SP, Sao Paulo, Brazil
    FEMS Immunol Med Microbiol 38:81-4. 2003
    ..Our finding points to a priming effect of SAA probably associated with mobilization of receptors for opsonized particles and strengthens the role of SAA as an effector of neutrophil functions in inflammation...
  95. ncbi Nonexpression of the human serum amyloid A three (SAA3) gene
    B Kluve-Beckerman
    Department of Medicine, Indiana University, Indianapolis
    DNA Cell Biol 10:651-61. 1991
    ....
  96. pmc Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function
    Leif E Sander
    Department of Medicine III, RWTH University Hospital, 52074 Aachen, Germany
    J Exp Med 207:1453-64. 2010
    ..Thus, gp130-dependent communication between the liver and MDSCs through APPs controls inflammatory responses during infection...
  97. ncbi Characterisation of the pig acute phase protein response to road transport
    Matilde Piñeiro
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, 50009 Zaragoza, Spain PigCHAMP Pro Europa S A Ctra San Rafael 42, 40006 Segovia, Spain
    Vet J 173:669-74. 2007
    ..The results demonstrate that shipment of pigs by road can result in an APP response that is probably related to the stress of transport...
  98. ncbi Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro
    Veneracion G Cabana
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Lipid Res 45:317-25. 2004
    ..In the absence of both apoA-I and apoE, SAA-HDL is not formed and SAA associates with any available lipoprotein...
  99. ncbi Anti-interleukin 6 receptor antibody inhibits murine AA-amyloidosis
    Masahiko Mihara
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co Ltd, Shizuoka, Japan
    J Rheumatol 31:1132-8. 2004
    ..We examined whether anti-interleukin 6 receptor (IL-6R) antibody prevented the development of AA-amyloidosis in mouse models...
  100. pmc Identification of a novel serum amyloid A protein in BALB/c mice
    M C De Beer
    Division of Rheumatology, University of Kentucky College of Medicine, Lexington
    Biochem J 280:45-9. 1991
    Four serum amyloid A protein (SAA) genes and two SAA gene products, SAA1 and SAA2, were identified in BALB/c mice...
  101. ncbi Interaction between serum amyloid A and leukocytes - a possible role in the progression of vascular complications in diabetes
    Elaine Hatanaka
    Departamento de Analises Clinicas e Toxicologicas, Universidade de Sao Paulo, Sao Paulo, CEP 05508 900, SP, Brazil
    Immunol Lett 108:160-6. 2007
    ..Accordingly, the hyper-responsiveness of leukocytes to SAA may be relevant to the proinflammatory conditions associated to vascular complications in diabetic patients...

Research Grants64

  1. METABOLISM OF SERUM AMYLOID A (SAA:HDL)
    Barbara Kluve Beckerman; Fiscal Year: 2007
    ..By clarifying pathogenic mechanisms at the cellular level, these studies will help identify potential targets for drugs aimed at inhibiting amyloid formation or arresting its progression. ..
  2. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..We seek support for additional blood markers to PROMIS by assaying plasma biomarkers potentially relevant to atherogenesis, plaque rupture and/or thrombosis. ..
  3. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..Understanding the pathogenesis of the reactive form of amyloidosis may reveal avenues for treatment of not only AA amyloidosis but also other forms of amyloidosis in the Veteran population. ..
  4. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ....
  5. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Shorter telomeres have been linked to cancer risk. The project includes 438 postmenopausal, overweight/obese, sedentary women who have already completed the trial from which blood samples will be used. ..
  6. Regulation of HMGB1 Release in Endotoxemia
    Haichao Wang; Fiscal Year: 2013
    ....
  7. Role of serum amyloid A in interferon-gamma expression and T helper 1 cell differ
    Rong Lucy He; Fiscal Year: 2013
    ....
  8. Impact of Inflammatory Genes on Glandular Hyperplasia in Children with Sinusitis
    Mary C Rose; Fiscal Year: 2010
    ....
  9. GRADS Cooperative Research Project: JHU Clinical Center
    David R Moller; Fiscal Year: 2013
    ..These studies may establish links between specific clinical phenotypes, microbial etiologies, and common pathogenic mechanisms to provide a framework for new therapeutic approaches to sarcoidosis. ..
  10. A Prospective Study of Colorectal Cancer: One-Carbon Metabolism and Inflammation
    Cornelia M Ulrich; Fiscal Year: 2012
    ..Through this research, we will learn more about how to prevent colorectal cancer and about possible public health recommendations based on genetic characteristics. ..
  11. PROTEINS OF COAGULATION PATHWAYS
    John H Griffin; Fiscal Year: 2013
    ..This project will reveal new insights into the pathophysiology of thrombosis and may improve diagnosis and treatment of thrombosis. ..
  12. Mechanisms of abdominal aortic aneurysm formation
    Alan Daugherty; Fiscal Year: 2010
    ..These projects will be supported by Cores of: A. Administration. B. Human studies. C. Mouse maintenance. D. Quantitative pathology. ..
  13. AMSA: ALXR/FBR Mediated Signaling in Severe Asthma
    Bruce D Levy; Fiscal Year: 2013
    ....
  14. HDL Structure and Metabolism During Inflammation
    Frederick C de Beer; Fiscal Year: 2011
    ..b>Serum amyloid A protein (SAA) is dramatically induced by cytokines and can even become the major apolipoprotein of HDL...
  15. Serum Amyloid A3 in Allergic Asthma: An Endogenous Mediator of Disease Severity
    Matthew E Poynter; Fiscal Year: 2013
    ....
  16. PATHOBIOLOGY OF MACROVASCULAR DISEASE IN DIABETES
    Karin E Bornfeldt; Fiscal Year: 2012
    ..The increased understanding of the pathogenesis of the premature vascular disease in diabetes that will be derived has important therapeutic implications for the prevention and treatment of macrovascular disease in diabetes. ..
  17. Regulation of NF-kB and 1kB Proteins
    Sankar Ghosh; Fiscal Year: 2010
    ..genes, including IL-1,IL-2, IL-2Ra, IL-6, IL-8,1L-12,TNF-a, p-IFN, GM-CS r, COX-2, E-selectin and serum amyloid A protein. NF-KB acts as a critical co-ordinating element in the body's response to infection and injury, and ..
  18. Blood Markers of Vulnerability in High Risk Vascular Patients
    Mary Mcgrae McDermott; Fiscal Year: 2012
    ..Findings may help clinicians identify patients who are at particularly high-risk for an impending heart attack. Results are also expected to elucidate specific triggers of acute coronary events. ..
  19. Chronic sialidase effects on amyloid aggregation and associated pathology
    Michael P McDonald; Fiscal Year: 2010
    ..However, GD3S is absent from birth in these mice, and they lack many of the gangliosides critical for normal brain development. The objective of the proa in Alzheimer patients. ..
  20. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  21. Smooth muscle cell lipid metabolism and serum amyloid A
    Barbara M Schreiber; Fiscal Year: 2010
    ..Cardiovascular disease remains a major public health concern. Elucidation of mechanisms that promote disease vs. protect against it will lead to future strategies for drug development. ..
  22. MOLECULAR ASPECTS OF AMYLOIDOSIS
    WARREN LIAO; Fiscal Year: 1999
    ..to study the pathogenesis of secondary amyloidosis using a transgenic animal model. ..
  23. Atherogenicity of Pathogens in Murine Model
    Catherine Champagne; Fiscal Year: 2003
    ..Results from these studies will help in the identification of new targets for atherosclerosis and vascular disease therapies. ..
  24. TRANSCRIPTIONAL CONTROL OF SERUM AMYLOID GENES
    Hugh Rienhoff; Fiscal Year: 1991
    ..Long-term goals of the investigator include contributing to our knowledge and treatment of hereditary disorders at a molecular level...
  25. REGULATION OF SERUM AMYLOID A PROTEIN SYNTHESIS
    BIMAL RAY; Fiscal Year: 1992
    ..These studies will enable the formation of the basis for future work regarding the regulation of SAA biosynthesis in patients with disease which predisposes to amyloidosis...
  26. Amyloid Precursor Proteins in Sarcoidosis
    DAVID MOLLER; Fiscal Year: 2005
    ..abstract_text> ..
  27. REGULATION OF C REACTIVE PROTEIN GENE EXPRESSION
    STEPHEN DOWTON; Fiscal Year: 1992
    ..The proposed studies will have general implications for understanding mechanisms of eukaryotic gene control as well as questions specifically related to cytokine mediated control of inflammation...
  28. A Thermo Electron LTQ Mass Spectrometer
    Joseph Zaia; Fiscal Year: 2006
    ..and post-trranslational modification structures of transthyretin, immunoglobulin light chains, and serum amyloid A protein in amyloid diseases (Skinner); (5) the role of decorins in corneal biochemistry (Trinkaus-Randall); (6) ..
  29. Exercise effects on oxidative damage among women
    Cornelia Ulrich; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. White matter damage in Alzheimer?s disease: New cellular targets and mechanisms
    Mark Noble; Fiscal Year: 2009
    ..This research will help in identifying new means of protecting against amyloid [unreadable] toxicity. ..
  31. GENERAL CLINICAL RESEARCH CENTER
    Paul Calabresi; Fiscal Year: 1990
    ..The 1,500 square foot facility, renovated through a private foundaton grant, will have capacity to serve 24 study subjects...
  32. Inhibition of TNF in Patients with Alcoholic Hepatitis
    Vijay Shah; Fiscal Year: 2005
    ..serial serum TNF bioactivity, IL-6 levels, and serum markers of inflammation (C-reactive protein and serum amyloid A protein) and hepatocyte regeneration (hepatocyte growth factor and transforming growth factor alpha) in control ..
  33. Analysis of lipids, inflammation, and pulmonary function
    GEORGE O CONNOR; Fiscal Year: 2003
    ..abstract_text> ..
  34. High throughput tau oligomer assay for drug screening for Alzheimer's disease
    James Moe; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. Novel Serum Markers for Pancreatic Adenocarcinoma
    SEAN MULVIHILL; Fiscal Year: 2006
    ..This work has direct health-related significance in identifying improved screening tests for pancreatic cancer. ..
  36. UV&IR MALDI REFLECTION TIME OF FLIGHT MASS SPECTROMETER
    Catherine Costello; Fiscal Year: 2001
    ..immunoglobin light chain fragments following indolent plasma cell dyscrasia in the bone marrow (AL), of serum amyloid A protein (systemic amyloidosis, AA) and of the serum protein transthyretin in patients having inherited genetic ..
  37. DIABETES AND CARDIOVASCULAR RISK IN MEXICO CITY
    Michael Stern; Fiscal Year: 2000
    ..e., the hypothesis that both type II diabetes and atherosclerosis have common genetic and environmental antecedents. ..
  38. MOLECULAR ASPECTS OF AMYLOIDOSIS
    WARREN LIAO; Fiscal Year: 1991
    ....
  39. HDL RECEPTOR SR B1--REGULATION AND ROLE
    DENEYS VAN DER WESTHUYZEN; Fiscal Year: 2000
    ..This will be achieved by determining the effect of adenovirus-mediated over-expression of SR-B1 on the levels of normal and acute phase HDL and of other lipoproteins. ..
  40. HUMAN LIPOPROTEIN PATHOPHYSIOLOGY
    JOHN ALBERS; Fiscal Year: 2009
    ..abstract_text> ..
  41. Inflammatory Genomics in Human Carotid Artery Disease
    GAIL JARVIK; Fiscal Year: 2006
    ..Genes that are implicated in disease may eventually allow targeted therapy. ..
  42. c-FN as a predictor of hemorrhagic transformation in t-PA treated stroke patients
    Albert Man; Fiscal Year: 2007
    ..Successful development will increase safety and usage of this highly beneficial treatment as well as lower overall healthcare cost as a result of stroke. [unreadable] [unreadable] [unreadable]..
  43. SAA and sPLA2 Role in Atherogenesis
    FREDERICK DE BEER; Fiscal Year: 2004
    ..The first is the cytokine mediated induction of acute phase serum amyloid A protein (SAA) that increases hundreds of fold and can even become the major apolipoprotein on HDL...
  44. SPLA2--INFLUENCE ON LIPOPROTEIN METABOLISM
    FREDERICK DE BEER; Fiscal Year: 2000
    ..These are the concomitant induction of cytokines of secretory non-pancreatic phospholipase A2(sPLA2) and serum amyloid A protein (SAA)...
  45. EUKARYOTIC GENE ISOLATION AND EXPRESSION
    John Morrow; Fiscal Year: 1980
    ..We also propose to isolate cDNA and genome clones encoding glutathione S-transferase and murine serum amyloid A. These will be used to explore the control of synthesis of their messenger RNAs. ..
  46. Sex steroid hormones and risk of Alzheimer's Disease with age
    Emily Rosario; Fiscal Year: 2007
    ..The proposed studies will utilize a combination of animal models and analyses of human tissues to investigate the hypothesis that age-related androgen depletion increases the risk for developing AD. [unreadable] [unreadable]..
  47. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  48. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..
  49. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  50. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  51. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  52. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  53. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  54. MECHANISM OF SERUM AMYLOID A PROTEIN SYNTHESIS
    BIMAL RAY; Fiscal Year: 2003
    ..abstract_text> ..
  55. Mechanism of MMP gene induction in osteoarthritis
    BIMAL RAY; Fiscal Year: 2004
    ..abstract_text> ..
  56. Inflammation and Infection as Risk Factors in Stroke
    Mitchell Elkind; Fiscal Year: 2006
    ..Nationally recognized experts in stroke epidemiology and basic vascular biology will serve as mentors for these studies. ..
  57. Inflammatory and Infectious Burden and Risk of Stroke
    Mitchell Elkind; Fiscal Year: 2008
    ..The cross-sectional associations between inflammatory and infectious markers and quantitative MRI abnormalities will also be assessed. ..
  58. MECHANISM OF SERUM AMYLOID A PROTEIN SYNTHESIS
    BIMAL RAY; Fiscal Year: 2005
    ..Results of these studies will improve understanding of the basic mechanisms of cellular response to inflammation and help in the development of a therapeutic regimen to control harmful effects of chronic inflammation. ..