ketocholesterols

Summary

Summary: Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro.

Top Publications

  1. ncbi Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death
    C Miguet
    , , INSERM U 498, BP 1542, 21034 Dijon Cedex, France
    Cell Death Differ 8:83-99. 2001
  2. ncbi Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
    Andrew J Brown
    School of Biotechnology and Biomolecular Sciences, Sydney, Australia
    Mol Aspects Med 30:111-22. 2009
  3. pmc Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages
    Natalie E Freeman
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
    J Lipid Res 46:1933-43. 2005
  4. pmc Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells
    W Martinet
    Division of Pharmacology, Department of Pharmaceutical Sciences, University of Antwerp, Wilrijk, Belgium
    Br J Pharmacol 154:1236-46. 2008
  5. ncbi In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress
    Hanna Larsson
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, SE 141 86 Stockholm, Sweden
    Free Radic Biol Med 43:695-701. 2007
  6. ncbi Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation
    Anne Vejux
    INSERM UMR 866 IFR100, CHU Hôpital du Bocage, BP77908, 21079, Dijon Cedex, France
    Histochem Cell Biol 127:609-24. 2007
  7. ncbi Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function
    Levente Kiss
    Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest 1082, Hungary
    Int J Mol Med 18:1113-7. 2006
  8. ncbi Oxidized lipoproteins and macrophages
    Wendy Jessup
    Cell Biology Group, Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Vascul Pharmacol 38:239-48. 2002
  9. pmc Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization
    Jiahn Dar Huang
    Mechanism of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1821:637-46. 2012
  10. ncbi 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells
    Won Hyo Lee
    Department of Pathology, Chungnam National University, College of Medicine, Taejon 301 747, Korea
    Z Naturforsch C 64:307-10. 2009

Detail Information

Publications151 found, 100 shown here

  1. ncbi Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death
    C Miguet
    , , INSERM U 498, BP 1542, 21034 Dijon Cedex, France
    Cell Death Differ 8:83-99. 2001
    ....
  2. ncbi Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
    Andrew J Brown
    School of Biotechnology and Biomolecular Sciences, Sydney, Australia
    Mol Aspects Med 30:111-22. 2009
    ..We summarise their location, generation, metabolism and elimination, as well as providing insights into the latest research into their regulatory roles in cholesterol homeostasis...
  3. pmc Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages
    Natalie E Freeman
    Department of Biochemistry and Molecular Biology, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 0581, USA
    J Lipid Res 46:1933-43. 2005
    ..These results suggest that 7KC not only initiates the apoptosis pathway by activating cPLA2, as we have reported previously, but also participates in the downstream signaling pathway when esterified by ACAT to form 7KC-arachidonate...
  4. pmc Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells
    W Martinet
    Division of Pharmacology, Department of Pharmaceutical Sciences, University of Antwerp, Wilrijk, Belgium
    Br J Pharmacol 154:1236-46. 2008
    ..Statins protect patients from myocardial infarction, though they induce SMC apoptosis. We investigated whether statins and 7-ketocholesterol exerted additive cell death effects...
  5. ncbi In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress
    Hanna Larsson
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, SE 141 86 Stockholm, Sweden
    Free Radic Biol Med 43:695-701. 2007
    ..In addition, the biological within-day and between-day variations of the two oxysterols were determined. In summary, the present investigation clearly shows an interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol in humans...
  6. ncbi Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation
    Anne Vejux
    INSERM UMR 866 IFR100, CHU Hôpital du Bocage, BP77908, 21079, Dijon Cedex, France
    Histochem Cell Biol 127:609-24. 2007
    ..These findings demonstrate that myelin figure formation is a caspase-independent event closely linked with the cytotoxicity of oxysterols, and they highlight a relationship between caspase activity and polar lipid accumulation...
  7. ncbi Effects of 7-ketocholesterol on the activity of endothelial poly(ADP-ribose) polymerase and on endothelium-dependent relaxant function
    Levente Kiss
    Department of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest 1082, Hungary
    Int J Mol Med 18:1113-7. 2006
    ..Our experimental results suggest that although 7-ketocholesterol can activate PARP enzyme in endothelial cells, it is not sufficient on its own to cause impairment in the endothelium-dependent vascular reactivity...
  8. ncbi Oxidized lipoproteins and macrophages
    Wendy Jessup
    Cell Biology Group, Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Vascul Pharmacol 38:239-48. 2002
    ..Here we review macrophage responses to oxidized lipoproteins and provide novel data on the effects of a major oxidation product, 7-ketocholesterol, on high-density lipoprotein (HDL) function in cholesterol removal from macrophages...
  9. pmc Sterculic acid antagonizes 7-ketocholesterol-mediated inflammation and inhibits choroidal neovascularization
    Jiahn Dar Huang
    Mechanism of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1821:637-46. 2012
    ..Our data suggests that sterculic acid may be useful in treating CNV in certain forms of age-related macular degeneration...
  10. ncbi 7-ketocholesterol induces endoplasmic reticulum stress in HT-29 cells
    Won Hyo Lee
    Department of Pathology, Chungnam National University, College of Medicine, Taejon 301 747, Korea
    Z Naturforsch C 64:307-10. 2009
    ..In the current study using the human colon cancer HT-29 cell line, we have demonstrated that 7-Kchol promotes endoplasmic reticulum (ER) stress via gene up-regulation of ER chaperone and membrane kinases...
  11. pmc 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation
    Ignacio M Larrayoz
    Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 51:4942-55. 2010
    ..The purpose of this study was to examine the signaling pathways involved in the 7KCh-mediated inflammatory response focusing on three cytokines, VEGF, IL-6, and IL-8...
  12. ncbi 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type
    Malgorzata Wamil
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5909-18. 2008
    ..Thus, the activity and reaction direction of adipose 11beta-HSD1 is altered under conditions of oxysterol excess, and could impact upon the pathophysiology of obesity and its complications...
  13. pmc 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation
    Ernesto F Moreira
    Section on Mechanisms of Retinal Diseases, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 50:523-32. 2009
    ..The purpose of this study was to identify and localize 7-ketocholesterol (7kCh) in the primate retina and to examine the potential consequences of its presence in oxidized lipid deposits in the retina...
  14. pmc OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids
    Riikka Hynynen
    National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
    J Lipid Res 50:1305-15. 2009
    ....
  15. ncbi 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways
    Arnaud Berthier
    INSERM U498 Métabolisme des lipoprotéines et interactions vasculaires, Dijon Cedex, France
    FEBS J 272:3093-104. 2005
    ..Therefore, it appears that 7-ketocholesterol-induced apoptosis is a complex phenomenon resulting from calcium-dependent activation of several pro-apoptotic pathways and also one survival pathway...
  16. ncbi Caspase-8, -12, and -3 activation by 7-ketocholesterol in retinal neurosensory cells
    Aneesh Neekhra
    Department of Ophthalmology, School of Medicine, University of California, Irvine, California, USA
    Invest Ophthalmol Vis Sci 48:1362-7. 2007
    ..To determine the caspase pathways involved with 7-ketocholesterol (7kCh)-induced apoptosis in rat R28 cells...
  17. pmc 7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death
    Marie Charlotte Royer
    INSERM UMR866 and Université de Bourgogne, F 21079 Dijon, France
    J Biol Chem 284:15826-34. 2009
    ..Akt-PKB dephosphorylation was prevented by alpha-tocopherol, but not gamma-tocopherol pretreatment...
  18. pmc The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is associated with an early activation of protein kinase C
    Valerie Deckert
    Laboratoire de Biochimie des Lipoprotéines INSERM U498, Faculte de Medecine, 7 Boulevard Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Br J Pharmacol 137:655-62. 2002
    ....
  19. ncbi Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat, Postfach 101007, D 40001 Dusseldorf, Germany
    Free Radic Biol Med 41:1139-50. 2006
    ..The dietary polyphenol (-)-epicatechin inhibited not only formation but also cytotoxic actions of both oxLDL and oxysterols...
  20. pmc 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol
    Tijana Mitić
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, Scotland, UK
    Biochimie 95:548-55. 2013
    ..This mechanism may be important in the cardioprotective effects of 11β-HSD1 inhibitors...
  21. ncbi Clinical significance of serum 7-ketocholesterol concentrations in the progression of coronary atherosclerosis
    Takashi Hitsumoto
    The Department of Internal Medicine, Sakura Medical Center, School of Medicine, Toho University, Chiba, Japan
    J Atheroscler Thromb 16:363-70. 2009
    ..The aim of this study was to clarify the clinical significance of serum 7-ketocholesterol concentrations (s-7KCHO) in the progression of coronary atherosclerosis...
  22. ncbi Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol
    Ignacio R Rodriguez
    Laboratory of Retinal Cell and Molecular Biology, Section on Mechanisms of Retinal Diseases, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Invest Ophthalmol Vis Sci 45:2830-7. 2004
    ..To determine which components present in oxidized LDL are responsible for the cytotoxicity associated with its internalization by culture ARPE19 cells...
  23. ncbi Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1
    Zoltan Balazs
    Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Mol Cell Endocrinol 301:117-22. 2009
    ..In conclusion, cellular factors such as H6PDH can significantly modulate the effect of inhibitors and alternative 7-oxygenated substrates on intracellular glucocorticoid availability...
  24. ncbi 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling
    Cheikh I Seye
    Laboratory of Pharmacology, University of Antwerp, Campus Drie Eiken, Wilrijk, B 2610 Antwerp, Belgium
    Cardiovasc Res 64:144-53. 2004
    ..We investigated whether cytochrome c release participated in SMC death induced by 7-ketocholesterol and whether the processes were reversible...
  25. ncbi Effects of oxygenated sterol on phospholipid bilayer properties: a molecular dynamics simulation
    A M Smondyrev
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chem Phys Lipids 112:31-9. 2001
    ..Results of our simulations are in a good agreement with the data available from the experiment...
  26. ncbi Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
    Anne Vejux
    DSV DIEP SBTN, Universite de Nice Sophia Antipolis, France
    Mol Aspects Med 30:153-70. 2009
    ..This basic knowledge on oxysterols contributes to a better understanding of the associated pathologies, so that new treatments and drugs can be designed...
  27. ncbi Lipids deposited in human atheromatous lesions induce apoptosis of human vascular smooth muscle cells
    Masaki Ohtsuka
    Department of Internal Medicine, Sakura Hospital, Medical Center of Toho University, 564 Shimoshizu, Sakura, Chiba 285 8741, Japan
    J Atheroscler Thromb 13:256-62. 2006
    ..These results suggest that lipids deposited in human atheromatous lesions may induce apoptosis of SMC and that oxysterols may be important factor contributing to induce apoptosis among deposited lipids...
  28. pmc Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration
    Ignacio R Rodriguez
    Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, Bethesda, MD 20892, USA
    J Lipid Res 51:2847-62. 2010
    ..The chronic mode of formation and the potent inflammatory properties of 7KCh indicate it may be an "age-related" risk factor in aging diseases such as atherosclerosis, Alzheimer's, and age-related macular degeneration...
  29. pmc Functional implications of plasma membrane condensation for T cell activation
    Carles Rentero
    Centre for Vascular Research, University of New South Wales and the Department of Haematology, Prince of Wales Hospital, Sydney, Australia
    PLoS ONE 3:e2262. 2008
    ..Our data emphasizes lipids as an important medium for the organization at T cell activation sites and strongly indicates that membrane condensation is an important element of the T cell activation process...
  30. ncbi Phlorizin- and 6-ketocholestanol-mediated antagonistic modulation of alamethicin activity in phospholipid planar membranes
    Tudor Luchian
    Department of Biophysics and Medical Physics, Faculty of Physics, Alexandru I Cuza University, Boulevard Carol I, no 11, Iasi, Romania, R 6600
    Langmuir 22:8452-7. 2006
    ....
  31. ncbi Early involvement of ROS overproduction in apoptosis induced by 7-ketocholesterol
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Turin, Italy
    Antioxid Redox Signal 8:375-80. 2006
    ..In fact, two metabolic inhibitors of NADPH-oxidase and the antioxidant epicatechin very well counteracted 7-ketocholesterol-induced apoptosis by preventing the oxysterol pro-oxidant action...
  32. ncbi Effect of agents modifying the membrane dipole potential on properties of syringomycin E channels
    Olga S Ostroumova
    Institute of Cytology of the Russian Academy of Sciences, St Petersburg 194064, Russia
    Langmuir 23:6889-92. 2007
    ..Overall, the results support the model of the small SRE channel synchronization in the cluster as voltage-dependent orientation of the lipid dipoles associated with the channel pores...
  33. pmc Iron nanoparticles increase 7-ketocholesterol-induced cell death, inflammation, and oxidation on murine cardiac HL1-NB cells
    Edmond Kahn
    INSERM U678 UMR S UPMC, IFR 14, CHU Pitie Salpetriere, 75634 Paris Cedex 13, France
    Int J Nanomedicine 5:185-95. 2010
    ....
  34. ncbi Determination of serum 7-ketocholesterol concentrations and their relationships with coronary multiple risks in diabetes mellitus
    Kei Endo
    The Center of Diabetes, Endocrinology, and Metabolism, Toho University Medical Center Sakura Hospital, 564 1 Shimoshizu, Sakura City, Chiba, Japan
    Diabetes Res Clin Pract 80:63-8. 2008
    ..3+/-7.0 ng/ml). Furthermore, s-7KCHO increased according to the number of concurrent coronary risk factors. These results suggest that serum 7-ketocholesterol levels may depend on the multiple risk factors and serum LDL-C levels...
  35. ncbi Impact of 7-ketocholesterol and very long chain fatty acids on oligodendrocyte lipid membrane organization: evaluation via LAURDAN and FAMIS spectral image analysis
    Edmond Kahn
    INSERM U678 UMR S UPMC, IFR 14, CHU Pitie Salpetriere, 75634 Paris Cedex 13, France
    Cytometry A 79:293-305. 2011
    ..Only 7KC was capable to induce a green emission with LAURDAN. Thus, at concentrations inducing oligodendrocyte cell death, 7KC (25 μM) is more efficient than C24:0 and C26:0 (20 μM), to trigger lateral lipid membrane disorganization...
  36. ncbi Influence of molecular dipoles on human skin permeability: Use of 6-ketocholestanol to enhance the transdermal delivery of bacitracin
    Josep Cladera
    School of Biomedical Sciences, Medical School, University of Nottingham, Nottingham NG 7 2UH, United Kingdom
    J Pharm Sci 92:1018-27. 2003
    ....
  37. ncbi Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme
    Roberto A S Schweizer
    Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne, 3010 Berne, Switzerland
    J Biol Chem 279:18415-24. 2004
    ..Together, our results suggest that 11beta-HSD1 efficiently catalyzes the first step in the rapid hepatic metabolism of dietary 7KC, which may explain why dietary 7KC has little or no effect on the development of atherosclerosis...
  38. pmc Sterol structure and sphingomyelin acyl chain length modulate lateral packing elasticity and detergent solubility in model membranes
    Xin Min Li
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912 3698, USA
    Biophys J 85:3788-801. 2003
    ....
  39. ncbi The polar nature of 7-ketocholesterol determines its location within membrane domains and the kinetics of membrane microsolubilization by apolipoprotein A-I
    John B Massey
    Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Biochemistry 44:10423-33. 2005
    ..Compared to cholesterol, 7-ketocholesterol can differentially modulate membrane properties involved in protein-membrane association and function...
  40. ncbi Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages
    Katharina Gaus
    Macrophage Biology Group, Centre for Vascular Research, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia
    FASEB J 18:574-6. 2004
    ..We propose that cholesterol exported to apoA-1 from this major slow efflux pool derives from nonraft regions of the plasma membrane but that the interaction of apoA-1 with lipid rafts is necessary to stimulate this efflux...
  41. ncbi Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis
    Anne Vejux
    INSERM U866, Faculte des Sciences Gabriel, 6 Bd Gabriel, 21000 Dijon, France
    J Nutr Biochem 20:45-61. 2009
    ..Thus, 7KC-induced apoptosis is a PI3-K-dependent event, and Vit-E up- and down-regulates PI3-K activity and phospholipidosis, respectively...
  42. ncbi Activation of caspase-3-dependent and -independent pathways during 7-ketocholesterol- and 7beta-hydroxycholesterol-induced cell death: a morphological and biochemical study
    Céline Prunet
    Inserm U498 IFR 100, CHU Hôpital du Bocage, Laboratoire de Biochimie Medicale, BP 77908, 21079 Dijon Cedex, France
    J Biochem Mol Toxicol 19:311-26. 2005
    ..We conclude that caspase-3 is essential to trigger 7-keto- and 7beta-OH-induced apoptosis, that these oxysterols simultaneously activate caspase-3-dependent and/or -independent modes of cell death...
  43. ncbi Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production
    G Lizard
    Inserm U498 Métabolisme des lipoprotéines humaines et interactions vasculaires, CHU Hôpital du Bocage, 2 bd Marechal de Lattre de tassigny, 21034 Dijon Cedex, France
    FASEB J 12:1651-63. 1998
    ..Taken together, our data demonstrate that GSH is implied in the control of 7-ketocholesterol-induced apoptosis associated with the production of ROS...
  44. ncbi Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus
    S Ferderbar
    Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Diabetes Metab Res Rev 23:35-42. 2007
    ..The aim of this study was to evaluate the formation of cholesterol oxides (ChOx) as biomarkers of oxidative stress in subjects with impaired glucose tolerance (IGT) and diabetes...
  45. ncbi Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1
    Alex Odermatt
    Department of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Freiburgstrasse 15, 3010 Berne, Switzerland
    Mol Cell Endocrinol 248:15-23. 2006
    ..These aspects may be relevant for understanding the physiological role of 11beta-HSD1 and for developing therapeutic interventions to control glucocorticoid reactivation...
  46. ncbi Effects of the membrane dipole potential on the interaction of saquinavir with phospholipid membranes and plasma membrane receptors of Caco-2 cells
    T Asawakarn
    School of Biomedical Sciences, University of Nottingham, Nottingham NG 7 2UH, United Kingdom
    J Biol Chem 276:38457-63. 2001
    ..Such a role is suggested to contribute to the altered behavior of receptor-mediated signaling systems in membrane rafts...
  47. ncbi Effects of caspase inhibitors (z-VAD-fmk, z-VDVAD-fmk) on Nile Red fluorescence pattern in 7-ketocholesterol-treated cells: investigation by flow cytometry and spectral imaging microscopy
    Anne Vejux
    INSERM UMR 866 Lipides, Nutrition et Cancer équipe Biochimie Métabolique et Nutritionnelle, IFR Santé STIC, Université de Bourgogne Faculté des Sciences Gabriel, 21000 Dijon, France
    Cytometry A 71:550-62. 2007
    ..So, we investigated the effects of the broad-spectrum caspase inhibitor z-VAD-fmk and of the caspase-2 inhibitor z-VDVAD-fmk on lipid profile evaluated by staining with Nile Red (NR)...
  48. pmc High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1
    Naoki Terasaka
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:15093-8. 2007
    ..These findings indicate a specific role for ABCG1 in promoting efflux of 7-ketocholesterol and related oxysterols from macrophages onto HDL and in protecting these cells from oxysterol-induced cytotoxicity...
  49. ncbi Baseline oxysterols and other markers of oxidative stress, inflammation and malnutrition in the vitamin e and intima media thickness progression in end-stage renal disease (VIPER) cohort
    Mona Boaz
    Epidemiology Unit, E Wolfson Medical Center, Holon, Israel
    Nephron Clin Pract 100:c111-9. 2005
    ..This study was designed to compare levels of the oxysterols 7-ketocholesterol (7KC) and 7beta-hydroxycholesterol (7betaOH) between a cohort of HD patients and healthy controls...
  50. ncbi 7-Ketocholesterol favors lipid accumulation and colocalizes with Nile Red positive cytoplasmic structures formed during 7-ketocholesterol-induced apoptosis: analysis by flow cytometry, FRET biphoton spectral imaging microscopy, and subcellular fractionati
    Anne Vejux
    INSERM U498, Hopital du Bocage, Dijon, France
    Cytometry A 64:87-100. 2005
    ..In this study on human promonocytic U937 cells, we determined the effects and the interactions of 7KC with cellular lipids during 7KC-induced apoptosis...
  51. ncbi Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi)
    Tatiana Saldanha
    Department of Food Science, Faculty of Food Engineering, State University of Campinas, 13083 862 Campinas, SP, Brazil
    Lipids 42:671-8. 2007
    ....
  52. ncbi 7-Ketocholesterol enhances 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells
    Y J Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul, South Korea
    J Neural Transm 113:1877-85. 2006
    ..The findings suggest that 7-ketocholesterol as a promoting agent for the formation of mitochondrial permeability transition may enhance the toxic neuronal cell injury...
  53. ncbi Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells
    Corinne Joffre
    Eye and Nutrition Research Group, INRA, UMR1129 FLAVIC, Dijon, France
    Curr Eye Res 32:271-80. 2007
    ..We investigated the effects of three oxysterols on mitochondrial dysfunctions, inflammation, and oxidative stress in primary cultures of porcine retinal pigment epithelial (RPE) cells...
  54. ncbi Redox regulation of 7-ketocholesterol-induced apoptosis by beta-carotene in human macrophages
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, L go F Vito, 1 00168 Rome, Italy
    Free Radic Biol Med 42:1579-90. 2007
    ..These data suggest a possible antiatherogenic role of beta-carotene through the prevention of 7-KC toxicity in human macrophages...
  55. ncbi Oxysterols regulate expression of the steroidogenic acute regulatory protein
    S R King
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mol Endocrinol 32:507-17. 2004
    ..Secondly, through direct conversion to steroid, oxysterols may account in part for StAR-independent steroid production in the body...
  56. ncbi High preoperative recipient plasma 7beta-hydroxycholesterol is associated with initial poor graft function after liver transplantation
    Stefano Ginanni Corradini
    Department of Clinical Medicine, Division of Gastroenterology, University La Sapienza, Via del Policlinico 155, 00161 Rome, Italy
    Liver Transpl 11:1494-504. 2005
    ..Oxysterols persisted elevated in plasma 1 month after OLT (n = 23). In conclusion, cirrhosis presents upregulated systemic oxidative stress likely of extrahepatic source that is associated with graft failure after OLT...
  57. ncbi Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy
    Marcello Arca
    Department of Clinical and Applied Medical Therapy, University La Sapienza, 00161 Rome, Italy
    Free Radic Biol Med 42:698-705. 2007
    ..More research work is needed to understand the clinical meaning of these findings, which may help to understand the role of oxidative stress in FCHL and lipid-lowering therapy...
  58. ncbi HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs
    Mônica R Mazalli
    Department of Food Science, Faculty of Food Engineering, State University of Campinas, 13083 862 Campinas, SP, Brazil
    Lipids 41:615-22. 2006
    ..The method showed accuracy and precision with a detection limit between 0.002 and 0.079 microg/g. The oxides cholest-5-ene-3beta,20alpha-diol and cholest-5-ene-3beta,25-diol identified by HPLC-UV-RI were not confirmed by HPLC-APCI-MS...
  59. ncbi Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor
    Chang Seok Lee
    Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea
    Neuroreport 17:183-7. 2006
    ..Thus, we conclude that it is most likely mediated by liver X receptor/retinoid X receptor heterodimers...
  60. ncbi Impairment of the cytotoxic and oxidative activities of 7 beta-hydroxycholesterol and 7-ketocholesterol by esterification with oleate
    Serge Monier
    Inserm U498 IFR 100 Inserm, CHU Hôpital du Bocage, Laboratoire de Biochimie Medicale, BP 77908, Dijon Cedex 21079, France
    Biochem Biophys Res Commun 303:814-24. 2003
    ....
  61. ncbi Chronic ethanol feeding increases 7-hydroperoxycholesterol and oxysterols in rat skeletal muscle
    Tetsuo Fujita
    Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Metabolism 51:737-42. 2002
    ..Their elevation in chronic experimental alcoholism, together with increases in cholesterol hydroperoxides, may possibly represent evidence of increased oxidative stress...
  62. ncbi Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaque
    Fausta Micheletta
    Dipartimento di Medicina Interna, University La Sapienza, Via del Policlinico, 155 00161 Rome, Italy
    Arterioscler Thromb Vasc Biol 24:136-40. 2004
    ..We analyzed whether vitamin E supplementation influences oxidative stress in plasma and atherosclerotic plaques of patients with severe atherosclerosis...
  63. ncbi Effect of oxysterols on hematopoietic progenitor cells
    Claudia C Gregorio-King
    Stem Cell Laboratory, The Douglas Hocking Research Institute, The Geelong Hospital, Victoria, Australia
    Exp Hematol 30:670-8. 2002
    ..Given the important regulatory role of apoptosis in hematopoiesis, we investigated the effects of oxysterols on human hematopoietic progenitor cells (HPCs)...
  64. ncbi Effect of chronic ethanol feeding on oxysterols in rat liver
    Koichi Ariyoshi
    Department of Legal Medicine, Kobe University Graduate School of Medicine, SE5 9RS, 7 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Free Radic Res 36:661-6. 2002
    ..0047). In conclusion, this is the first report of increased 7 alpha-OOH, 7 beta-OOH, and 7-keto in liver of rats and their elevation in chronic experimental alcoholism represent evidence of increased oxidative stress...
  65. ncbi 24-hydroxycholesterol is a substrate for hepatic cholesterol 7alpha-hydroxylase (CYP7A)
    M Norlin
    Division of Biochemistry, Department of Pharmaceutical Biosciences, University of Uppsala, S 751 23 Uppsala, Sweden
    J Lipid Res 41:1629-39. 2000
    ....
  66. ncbi The effect of calcium dobesilate on vascular endothelial function, blood pressure, and markers of oxidation in obese male smokers: a placebo-controlled randomised clinical trial
    Miranda T Schram
    Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, Netherlands
    Atherosclerosis 170:59-72. 2003
    ..Thus, our data provide no evidence of an effect on vascular function of calcium dobesilate in humans...
  67. ncbi Chronology of cellular alterations during 7-ketocholesterol-induced cell death on A7R5 rat smooth muscle cells: analysis by time lapse-video microscopy and conventional fluorescence microscopy
    Jean Marie Zahm
    Institut National de la Santé et de la Recherche Médicale U514, Reims, France
    Cytometry A 52:57-69. 2003
    ..In addition, changes in actin organization were followed by conventional fluorescence microscopy...
  68. ncbi Protection of superoxide-induced cholesterol oxidation by antioxidants in protic conditions
    A Saari Csallany
    Department of Food Science and Nutrition, University of Minnesota, St Paul 55108, USA
    Int J Food Sci Nutr 53:403-9. 2002
    ..The presence of antioxidants markedly retarded the formation of 7-ketocholesterol. The formation of 7beta-hydroxycholesterol or 7alpha-hydroxycholesterol was also reduced, but to a lesser degree...
  69. ncbi Alpha-tocopherol prevents apoptosis of vascular endothelial cells via a mechanism exceeding that of mere antioxidation
    Manabu Uemura
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamigyo, Japan
    Eur J Pharmacol 456:29-37. 2002
    ..Our study suggests that alpha-Toc protects against apoptosis not only by scavenging reactive oxygen species, but also by inhibiting caspase activity, which means that its activity may exceed that of a mere antioxidant...
  70. ncbi Covalent binding of oxidized cholesteryl esters to protein: implications for oxidative modification of low density lipoprotein and atherosclerosis
    Yoshichika Kawai
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 278:21040-9. 2003
    ..The results of this study suggest that the binding of cholesteryl ester core aldehydes to LDL might represent the process common to the oxidative modification of lipoproteins...
  71. ncbi Lysophosphatidylcholine regulates synthesis of biglycan and the proteoglycan form of macrophage colony stimulating factor
    Mary Y Chang
    Department of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
    Arterioscler Thromb Vasc Biol 23:809-15. 2003
    ..It is not known which component of Ox-LDL is responsible for these effects. This study investigated the ability of several bioactive components of Ox-LDL to regulate proteoglycan synthesis...
  72. ncbi Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases small star, filled
    Henrique Girao
    Centre of Ophthalmology, Biomedical Institute for Research in Light and Image IBILI, Faculty of Medicine, University of Coimbra, 3000 Coimbra, Portugal
    Exp Cell Res 291:502-13. 2003
    ....
  73. ncbi Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I
    J Han
    Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 276:16567-72. 2001
    ....
  74. ncbi Metabolism of an oxysterol, 7-ketocholesterol, by sterol 27-hydroxylase in HepG2 cells
    M A Lyons
    Cell Biology Group, Heart Research Institute, Sydney, New South Wales, Australia
    Lipids 36:701-11. 2001
    ..This is the first study to demonstrate that sterol 27-hydroxylase plays an important role in the metabolism of oxysterols such as 7K in liver cells...
  75. ncbi Trojan horse-like behavior of a biologically representative mixture of oxysterols
    Gabriella Leonarduzzi
    Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole, 10, 10043 Orbassano, Torino, Italy
    Mol Aspects Med 25:155-67. 2004
    ..Competition among oxysterols, apparently at NADPH oxidase level, diminishes the macrophage ROS production and direct toxicity that is evoked by defined oxysterols, as for instance, 7-ketocholesterol...
  76. ncbi [Concentration of the oxygenated derivates of cholesterol in pregnant women suffering from diabetes type I]
    Piotr Bodzek
    Katedry i Oddziału Klinicznego Połoznictwa i Ginekologii w Bytomiu
    Wiad Lek 55:50-3. 2002
    ....
  77. ncbi 7-Ketocholesterol forms crystalline domains in model membranes and murine aortic smooth muscle cells
    J E Phillips
    Membrane Biophysics Laboratory, Department of Medicine, Division of Cardiology, MCP Hahnemann University, Allegheny Campus, 320 East North Avenue, Pittsburgh, PA 15212-4772, USA
    Atherosclerosis 159:125-35. 2001
    ..While these domains may decrease its cytotoxicity by inducing the formation of sterol crystals in smooth muscle cells, they may, in a broader capacity, contribute to the sterol crystals found in advanced atherosclerotic lesions...
  78. ncbi Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols
    J A Woods
    Department of Food Science, Food Technology and Nutrition, University College, Cork, Ireland
    Cell Biol Toxicol 17:127-37. 2001
    ..Therefore, oxysterol-induced apoptosis may not be dependent on the generation of an oxidative stress...
  79. ncbi Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha
    T A Spencer
    Dartmouth College, Hanover, New Hampshire 03755, USA
    J Med Chem 44:886-97. 2001
    ..This model may aid the design of synthetic drugs targeted at this transcriptional regulator of cholesterol homeostasis...
  80. ncbi Flow cytometry and factor analysis evaluation of confocal image sequences of morphologic and functional changes occurring at the mitochondrial level during 7-ketocholesterol-induced cell death
    Edmond Kahn
    National Institute of Health and Medical Research U494, Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Anal Quant Cytol Histol 24:355-62. 2002
    ..To analyze functional and morphologic alterations that occur at the mitochondrial level by flow cytometry and laser scanning confocal microscopy (CLSM) combined with factor analysis of biomedical image sequences (FAMIS)...
  81. ncbi Cholesterol interaction with free radicals produced from carbon tetrachloride or bromotrichloromethane by either catalytic decomposition or via liver microsomal activation
    S L Fanelli
    Centro de Investigaciones Toxicológicas CEITOX CITEFA CONICET, Pcia de Buenos Aires, Argentina
    Chem Biol Interact 98:223-36. 1995
    ..Two additional reaction products were determined as ketocholesterols (IV and V). One chloro Ch was also formed (VI)...
  82. pmc 11β-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE⁻/⁻ mice
    Ricardo A Garcia
    Cardiovascular Drug Discovery, Bristol Myers Squibb Company, Pennington, New Jersey, United States of America
    PLoS ONE 8:e53192. 2013
    ..Pharmacological inhibition of 11βHSD1 has been shown to reduce atherosclerosis in murine models. However, the cellular and molecular details for this effect have not been elucidated...
  83. ncbi [Variance of expressions of extracellular matrix components and effects of anti-osteoporotic drugs on Mönckeberg's arteriosclerosis]
    Eiji Saitoh
    Department of Clinical Chemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
    Yakugaku Zasshi 128:385-92. 2008
    ..Thereupon, it was revealed that 7kc drastically accelerated Pi-induced calcification, and risedronate completely restored the calcification and mRNA expression accelerated by 7kc...
  84. ncbi Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, 1 00168 Rome, Italy
    J Nutr Biochem 21:34-46. 2010
    ..Our study suggests that lycopene may act as a potential antiatherogenic agent by preventing 7-KC-induced oxidative stress and apoptosis in human macrophages...
  85. ncbi Regulation of the expression of interleukin-8 induced by 25-hydroxycholesterol in retinal pigment epithelium cells
    Steve Catarino
    Centre of Ophthalmology and Vision Sciences COCV, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Acta Ophthalmol 90:e255-63. 2012
    ..This study aimed at elucidating the molecular mechanisms involved in the regulation of IL-8 production by several oxysterols in retinal pigment epithelium (RPE) cells...
  86. ncbi Influence of phloretin and 6-ketocholestanol on the permeation of progesterone through porcine skin
    C Valenta
    Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A 1090, Vienna, Austria
    Int J Pharm 217:79-86. 2001
    ..Both showed a lowering ( approximately 5-6 degrees C) in the lipid phase transition temperature that occurs around 75 degrees C in porcine skin...
  87. ncbi Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells
    Monica Deiana
    Dipartimento di Biologia Sperimentale, Sezione di Patologia Sperimentale, Universita degli Studi di Cagliari, Cittadella Universitaria SS 554, 09042 Monserrato, Cagliari, Italy
    Food Chem Toxicol 48:3008-16. 2010
    ..In vitro trials, where the simple phenols were tested during linoleic acid and cholesterol oxidation, gave evidence of a direct scavenging of peroxyl radicals and suggested a hydrogen atom-donating activity...
  88. ncbi Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity
    Irving L M H Aye
    School of Women s and Infants Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
    Biochim Biophys Acta 1801:1013-24. 2010
    ..These results identify syncytial ABCA1 and ABCG1 as important, inducible cholesterol transporters which also prevent placental accumulation of cytotoxic oxysterols...
  89. ncbi Analysis of cholesterol oxidation products in biological samples
    Ulf Diczfalusy
    Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Chemistry, Huddinge University Hospital C1 74, SE 141 86 Huddinge, Sweden
    J AOAC Int 87:467-73. 2004
    ..As oxysterols are found to participate in an increasing number of cellular events, it is obvious that improved methods are needed for their analysis to understand their roles in the living cell...
  90. ncbi Presence of phytosterol oxides in crude vegetable oils and their fate during refining
    Renzo Bortolomeazzi
    Food Science Department, Udine University, via Marangoni 97, 33100 Udine, Italy
    J Agric Food Chem 51:2394-401. 2003
    ..of steratrienes from these compounds, but dihydroxycholesterol underwent considerable decomposition and alpha-epoxycholesterol underwent ring opening with formation of the dihydroxy derivative, whereas 7-ketocholesterol was rather stable..
  91. ncbi LDL oxidative modifications in well- or moderately controlled type 2 diabetes
    P G Scheffer
    Metabolic Laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 20:298-304. 2004
    ....
  92. ncbi Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol
    I Tabas
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Death Differ 11:S12-6. 2004
  93. ncbi In vitro effect of cholesterol on calcifying activity of vesicles isolated from rabbit aortas
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
    Biochim Biophys Acta 1638:235-40. 2003
    ..Altogether, these observations suggest that cholesterol and especially its oxidized forms may induce aortic calcification by directly enhancing the vesicle's ability to calcify...
  94. ncbi 7-ketocholesterol inhibits Na,K-ATPase activity by decreasing expression of its α1-subunit and membrane fluidity in human endothelial cells
    M J Duran
    INSERM U603, Marseille, France
    Cell Mol Biol (Noisy-le-grand) 56:OL1434-41. 2010
    ..These data demonstrate that 7-ketocholesterol induces endothelial dysfunction without cell death that may contribute to early events in atherosclerosis...
  95. ncbi 7-Ketocholesterol delivered to mice in chylomicron remnant-like particles is rapidly metabolised, excreted and does not accumulate in aorta
    M A Lyons
    Cell Biology Group, Heart Research Institute, 145 Missenden Road, Camperdown, 2050, Sydney, Australia
    Biochim Biophys Acta 1530:209-18. 2001
    ..Indeed, the data encourage further investigation into the contribution that dietary oxysterols may or may not make to atherogenesis...
  96. pmc A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma
    Xuntian Jiang
    Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 52:1435-45. 2011
    ..The LC-MS/MS assay was able to discriminate with high sensitivity and specificity between control and NPC1 subjects, and offers for the first time a noninvasive, rapid, and highly sensitive method for diagnosis of NPC1 disease...
  97. ncbi The effect of oxycholesterols on thermo-induced membrane dynamics
    Mun delanji C Vestergaard
    School of Materials Science, Japan Advanced Institute of Science and Technology JAIST, 1 1 Asahidai, Nomi, Ishikawa 923 1292, Japan
    Biochim Biophys Acta 1808:2245-51. 2011
    ..These findings improve the mechanisms reported previously that attributed the induced dynamics solely to membrane oxidation...
  98. ncbi Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterols
    Wei Li
    Division of Experimental Pathology, Department of Clinical and Experimental Medicine, Linkoping University, Linköping 581 85, Sweden
    Biochem Biophys Res Commun 409:711-6. 2011
    ..The results suggest the cell death induced by 7-oxysterols may contribute to endothelial dysfunction and atherothrombosis...
  99. ncbi Absorption of cholesterol oxidation products from ordinary foodstuff in humans
    J Linseisen
    Institute of Nutrition Science of the Technical University of Munich, Germany
    Ann Nutr Metab 42:221-30. 1998
    ..Information on the absorption of cholesterol oxidation products (COP) from ordinary foodstuff in humans is scarce...
  100. pmc ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet
    Naoki Terasaka
    Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 118:3701-13. 2008
    ..Our data suggest that ABCG1 and HDL maintain EC function in HCD-fed mice by promoting efflux of cholesterol and 7-oxysterols and preserving active eNOS dimer levels...
  101. pmc AM-251 and SR144528 are acyl CoA:cholesterol acyltransferase inhibitors
    Douglas Thewke
    Department of Biochemistry and Molecular Biology, Quillen College of Medicine, East Tennessee State University, 807 University Parkway, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 381:181-6. 2009
    ..This work is the first evidence that AM-251 and SR144528 are inhibitors of ACAT and as a result, might have anti-atherosclerotic activities independent of their affect on cannabinoid signaling...

Research Grants9

  1. INTERACTION OF ATHEROGENIC LIPOPROTEINS WITH MACROPHAGES
    IRA A TABAS; Fiscal Year: 2010
    ..abstract_text> ..
  2. FORM CELL APO (A)/LP(A) RECEPTOR--CLONING AND FUNCTION
    Ira Tabas; Fiscal Year: 2002
    ..The studies in this proposal will lead to the molecular identification of a novel cholesterol-induced receptor on foam cells and should provide important insight into the role of foam cell-apo(a)/Lp(a) interactions in atherogenesis. ..
  3. EXTRACELLULAR MATRIX ABNORMALITIES IN CORNEAL EDEMA
    MARIA KENNEY; Fiscal Year: 2002
    ....
  4. Abnormalities in Keratoconus Corneas
    MARIA KENNEY; Fiscal Year: 2003
    ..These studies will provide fundamental insights into KC pathogensis and may provide a basis for therapy. ..
  5. Mineralization studies related to atherosclerosis
    HOWARD HSU; Fiscal Year: 2004
    ..abstract_text> ..
  6. Regulation of stearoyl-CoA desaturases by oleate
    Douglas Thewke; Fiscal Year: 2004
    ..Ectotopic expression of SREBPs or other trans-acting factors will be used to determine their contribution to oleate regulation of SCD transcription. ..
  7. Conference on Cellular Biology of Atherosclerosis
    Ira Tabas; Fiscal Year: 2005
    ....
  8. Macrophage Death in Plaque Vulnerability
    Ira Tabas; Fiscal Year: 2005
    ..New insights in this area may suggest new therapeutic strategies to combat cardiovascular disease. ..
  9. The role of CB2 receptors in oxLDL-induced apopotosis and atherogenesis
    Douglas Thewke; Fiscal Year: 2006
    ..They may also provide new pharmacologically exploitable targets for the development of novel pharmaceuticals for treatment of atherosclerosis. [unreadable] [unreadable] [unreadable]..