hydroxycholesterols

Summary

Summary: Cholesterol which is substituted by a hydroxy group in any position.

Top Publications

  1. ncbi Oxysterols direct immune cell migration via EBI2
    Sébastien Hannedouche
    Euroscreen s a, 6041 Gosselies, Belgium
    Nature 475:524-7. 2011
  2. pmc Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
    Ulf Diczfalusy
    Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Lipid Res 50:2258-64. 2009
  3. ncbi Oxysterols direct B-cell migration through EBI2
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, California 92121, USA
    Nature 475:519-23. 2011
  4. pmc Oxysterols are allosteric activators of the oncoprotein Smoothened
    Sigrid Nachtergaele
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    Nat Chem Biol 8:211-20. 2012
  5. ncbi Oxysterols and atherosclerosis
    A J Brown
    Cell Biology Group, Heart Research Institute, Sydney, NSW, Australia
    Atherosclerosis 142:1-28. 1999
  6. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
  7. pmc Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
    Rebecca Schule
    Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
    J Lipid Res 51:819-23. 2010
  8. ncbi Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
    Andrew J Brown
    School of Biotechnology and Biomolecular Sciences, Sydney, Australia
    Mol Aspects Med 30:111-22. 2009
  9. pmc Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
    Arun Radhakrishnan
    Department of Molecular Genetics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:6511-8. 2007
  10. ncbi Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
    Christopher M Adams
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:52772-80. 2004

Research Grants

  1. MACROPHAGE DERIVED FACTOR AND LEYDIG CELL FUNCTION
    JAMES HUTSON; Fiscal Year: 2001
  2. The pharmacological actions of antiprogestins in uterine fibroids
    Donald P McDonnell; Fiscal Year: 2010
  3. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
  4. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
  5. Fetal Origin of Male Reproductive Disorders
    Vassilios Papadopoulos; Fiscal Year: 2009
  6. ACUTE HORMONAL REGULATION OF STEROIDOGENESIS
    Vassilios Papadopoulos; Fiscal Year: 2008
  7. Role of Egr-1 in Corpus Luteum Function
    John Davis; Fiscal Year: 2006
  8. Attenuating sterol synthesis in WT and NPC mice brains
    Ta Yuan Chang; Fiscal Year: 2005
  9. IGF-I SIGNALING IN GRANULOSA CELLS
    John Davis; Fiscal Year: 2004
  10. Development of peptide antagonists of estrogen signaling
    Donald McDonnell; Fiscal Year: 2005

Detail Information

Publications217 found, 100 shown here

  1. ncbi Oxysterols direct immune cell migration via EBI2
    Sébastien Hannedouche
    Euroscreen s a, 6041 Gosselies, Belgium
    Nature 475:524-7. 2011
    ..This demonstrates that CH25H generates EBI2 biological activity in vivo and indicates that the EBI2-oxysterol signalling pathway has an important role in the adaptive immune response...
  2. pmc Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
    Ulf Diczfalusy
    Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Lipid Res 50:2258-64. 2009
    ..The possibility is discussed that 25-hydroxycholesterol may have a role in the inflammatory response, in addition to its more established role in the regulation of cholesterol homeostasis...
  3. ncbi Oxysterols direct B-cell migration through EBI2
    Changlu Liu
    Johnson and Johnson Pharmaceutical Research and Development, L L C, 3210 Merryfield Row, San Diego, California 92121, USA
    Nature 475:519-23. 2011
    ....
  4. pmc Oxysterols are allosteric activators of the oncoprotein Smoothened
    Sigrid Nachtergaele
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA
    Nat Chem Biol 8:211-20. 2012
    ..Our work suggests that these enigmatic sterols, which have multiple effects on cell physiology, may act as ligands for signaling receptors and provides a generally applicable framework for probing sterol signaling mechanisms...
  5. ncbi Oxysterols and atherosclerosis
    A J Brown
    Cell Biology Group, Heart Research Institute, Sydney, NSW, Australia
    Atherosclerosis 142:1-28. 1999
    ....
  6. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
    ..The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system...
  7. pmc Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
    Rebecca Schule
    Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tubingen, Tubingen, Germany
    J Lipid Res 51:819-23. 2010
    ..If the accumulation of 27-hydroxycholesterol is an important pathogenetic factor, a reduction of its levels may reduce or prevent the neurological symptoms. A possible strategy to achieve this is discussed...
  8. ncbi Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis
    Andrew J Brown
    School of Biotechnology and Biomolecular Sciences, Sydney, Australia
    Mol Aspects Med 30:111-22. 2009
    ..We summarise their location, generation, metabolism and elimination, as well as providing insights into the latest research into their regulatory roles in cholesterol homeostasis...
  9. pmc Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
    Arun Radhakrishnan
    Department of Molecular Genetics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:6511-8. 2007
    ..These studies define Insigs as oxysterol-binding proteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal cells...
  10. ncbi Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
    Christopher M Adams
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:52772-80. 2004
    ..These data imply that cholesterol interacts with SCAP directly by inducing it to bind to Insigs, whereas 25-HC works indirectly through a putative 25-HC sensor protein that elicits SCAP-Insig binding...
  11. ncbi Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes
    Xiaobo Li
    Department of Medicine Veterans Affairs McGuire Medical Center, Virginia Commonwealth University, Richmond, VA 23249, USA
    J Lipid Res 48:2587-96. 2007
    ..Specific small interfering RNA decreased SULT2B1b mRNA, protein, and activity levels. These findings demonstrate that mitochondria synthesize 25HC, which is subsequently 3beta-sulfated to form 25HC3S...
  12. ncbi Oxysterol biosynthetic enzymes
    D W Russell
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235 9046, USA
    Biochim Biophys Acta 1529:126-35. 2000
    ..This article focuses on the properties of these enzymes...
  13. ncbi Patched1 regulates hedgehog signaling at the primary cilium
    Rajat Rohatgi
    Departments of Developmental Biology, Genetics, and Bioengineering and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 317:372-6. 2007
    ..When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function...
  14. ncbi Oxysterols as markers of neurological disease--a review
    Valerio Leoni
    Division of Biochemistry and Genetics, National Institute of Neurology C Besta, Milan, Italy
    Scand J Clin Lab Invest 69:22-5. 2009
    ..Compared with other available biomarkers in CSF, such as Total Tau, Phospo-Tau and beta(42) amyloid, the 24S-hydroxycholesterol appears to be the most sensitive biomarker in the evaluation of patients with cognitive impairment disease...
  15. pmc Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA
    J Alzheimers Dis 19:1007-19. 2010
    ..We propose that leptin administration may prevent the progression of sporadic forms of AD that are related to increased cholesterol and oxidized cholesterol metabolite levels...
  16. pmc Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    S Alberti
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Clin Invest 107:565-73. 2001
    ..Thus, our data indicate that LXRbeta has no complete overlapping function compared with LXRalpha in the liver...
  17. pmc Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma
    Lihua Jin
    Key Laboratory for Cell Biology and Tumor Cell Engineering of the Ministry of Education, Xiamen University, Fujian 361005, China
    Mol Endocrinol 24:923-9. 2010
    ..In this study, we showed that hydroxycholesterols promote the recruitment of coactivators by RORgamma using biochemical assays...
  18. ncbi Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression
    Paola Palozza
    Institute of General Pathology, Catholic University School of Medicine, 00168 Rome, Italy
    J Nutr Biochem 22:259-68. 2011
    ..Taken all together, these data bring new information on the anti-atherogenic properties of lycopene, and on its mechanisms of action in atherosclerosis prevention...
  19. ncbi Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Japan
    Respirology 17:533-40. 2012
    ..The aim of this study was to assess the production of 25-HC in the airways and to elucidate the role of 25-HC in neutrophil infiltration in the airways of patients with chronic obstructive pulmonary disease (COPD)...
  20. pmc Cholesterol 25-hydroxylation activity of CYP3A
    Akira Honda
    Department of Gastroenterology, Center for Collaborative Research, Ibaraki 300 0395, Japan
    J Lipid Res 52:1509-16. 2011
    ..650, P < 0.0001, n = 78), but did not significantly correlate with the levels of 27-hydroxycholesterol or 24S-hydroxycholesterol. These results demonstrate the significance of CYP3A on the production of 25-hydroxycholesterol...
  21. ncbi Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
    Maura Heverin
    Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    J Lipid Res 45:186-93. 2004
    ..The high correlation between lathosterol and 24-hydroxycholesterol is consistent with a close coupling between synthesis and metabolism of cholesterol in the frontal cortex of the AD brain...
  22. ncbi 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
    Michihisa Umetani
    Department of Pharmacology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, Texas 75390 9050, USA
    Nat Med 13:1185-92. 2007
    ..Taken together, these studies point to 27HC as a contributing factor in the loss of estrogen protection from vascular disease...
  23. ncbi In vivo interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol, potential surrogate markers for oxidative stress
    Hanna Larsson
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Huddinge, SE 141 86 Stockholm, Sweden
    Free Radic Biol Med 43:695-701. 2007
    ..In addition, the biological within-day and between-day variations of the two oxysterols were determined. In summary, the present investigation clearly shows an interconversion of 7beta-hydroxycholesterol and 7-ketocholesterol in humans...
  24. pmc Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus
    Jaya R P Prasanthi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, United States of America
    PLoS ONE 6:e26420. 2011
    ....
  25. ncbi A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken
    Yorio Maeda
    Department of Surgery I, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Steroids 67:703-8. 2002
    ..7Beta-hydroxycholesterol was converted to 7-ketocholesterol in all vertebrates tested. The interconversion between 7alpha- and 7beta-hydroxycholesterol via 7-ketocholesterol was observed in the hamster in this in vitro study...
  26. ncbi Arachidonate metabolism and the signaling pathway of induction of apoptosis by oxidized LDL/oxysterol
    S R Panini
    Department of Biochemistry and Molecular Biology, James H. Quillen College of Medicine, East Tennessee State University, Ross Drive, Building 11, Johnson City, TN 37614, USA
    J Lipid Res 42:1678-86. 2001
    ....
  27. ncbi Comparative study of the cytotoxicity and apoptosis-inducing potential of commonly occurring oxysterols
    J A Woods
    Department of Food Science, Food Technology and Nutrition, University College, Cork, Ireland
    Cell Biol Toxicol 17:127-37. 2001
    ..Therefore, oxysterol-induced apoptosis may not be dependent on the generation of an oxidative stress...
  28. ncbi Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain
    I Bjorkhem
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska University Hospital, Huddinge, Sweden
    J Intern Med 260:493-508. 2006
    ..An overview of the above studies is presented and the possibility that the cholesterol 24S-hydroxylase in the brain may be important for memory and learning and that it may be a new drug target is discussed...
  29. ncbi 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type
    Malgorzata Wamil
    Endocrinology Unit, Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5909-18. 2008
    ..Thus, the activity and reaction direction of adipose 11beta-HSD1 is altered under conditions of oxysterol excess, and could impact upon the pathophysiology of obesity and its complications...
  30. ncbi Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols
    Joelle Makoukji
    University Paris Descartes, Unité Mixte de Recherche UMR 8194, Centre National de la Recherche Scientifique CNRS, 75270 Paris, France
    J Neurosci 31:9620-9. 2011
    ....
  31. ncbi Differential expression of cholesterol hydroxylases in Alzheimer's disease
    James Brown
    Departments of Pharmacology and Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    J Biol Chem 279:34674-81. 2004
    ....
  32. pmc Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes
    Shunlin Ren
    Department of Medicine, Veterans Affairs McGuire Medical Center Virginia Commonwealth University, Richmond, VA 23249, USA
    Biochem Biophys Res Commun 360:802-8. 2007
    ..In contrast, 25-hydroxycholesterol increased SREBP1 and FAS mRNA levels in primary human hepatocytes. The results imply that 25HC3S is a potent regulator of SREBP mediated lipid metabolism...
  33. pmc 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator
    Carolyn D DuSell
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 22:65-77. 2008
    ..Moreover, given the product-precursor relationship between 27HC and cholesterol, our findings have implications with respect to breast cancer risk in obese/hypercholesteremic individuals...
  34. pmc OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids
    Riikka Hynynen
    National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
    J Lipid Res 50:1305-15. 2009
    ....
  35. ncbi Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain
    Maura Heverin
    Department of Surgical Sciences, Karolinska University Hospital, Solna, Sweden
    J Lipid Res 46:1047-52. 2005
    ....
  36. pmc Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo
    Jared S Johnson
    Department of Orthopedic Surgery, UCLA, Los Angeles, California, USA
    J Cell Biochem 112:1673-84. 2011
    ..These data suggest that Oxy34 and Oxy49 are effective novel osteoinductive molecules and may be suitable candidates for further development and use in orthopedic indications requiring local bone formation...
  37. ncbi Role of 8-iso-prostaglandin F2alpha and 25-hydroxycholesterol in the pathophysiology of endometriosis
    Indu Sharma
    Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Fertil Steril 94:63-70. 2010
    ..To investigate the involvement of 8-iso-PGF(2alpha) and 25-hydroxycholesterol (25-OH-Chol) in the pathophysiology of endometriosis...
  38. ncbi Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis
    Jung Hwan Yoon
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea
    Hepatology 39:732-8. 2004
    ..This enhanced COX-2 protein expression by oxysterols may participate in the genesis and progression of cholangiocarcinoma...
  39. pmc Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions
    Sarah E Gale
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:1755-64. 2009
    ..These studies implicate oxysterol-membrane interactions in acute regulation of sterol homeostatic responses and provide new insights into the mechanism through which oxysterols regulate cellular cholesterol balance...
  40. ncbi Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients
    C E Teunissen
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, FdG, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Neurosci Lett 347:159-62. 2003
    ..The decreased levels of brain specific and peripheral sterols indicate a role for cholesterol homeostasis in relation to the pathology of multiple sclerosis, at least in the primary progressive clinical subtype...
  41. ncbi Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
    H Rosen
    Department of Molecular Virology, Faculty of Medicine, Hebrew University, 91120 Jerusalem, Israel
    J Biol Chem 273:14805-12. 1998
    ..The results do not support the contention that 27-hydroxylated steroids are critical for maintenance of cholesterol homeostasis or levels of vitamin D metabolites in the circulation...
  42. pmc Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol
    Gurdeep Marwarha
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58202, USA
    Cell Signal 24:484-92. 2012
    ..Our study implicates ER stress as the mechanistic link in the 27-OHC-induced negative regulation of leptin, a hormone that has potential therapeutic effects in AD by reducing Aβ and phosphorylated tau accumulation...
  43. ncbi Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling
    F Gilardi
    Laboratory of Biochemistry and Molecular Biology of Lipids Mass spectrometry Giovanni Galli, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Neuroscience 164:530-40. 2009
    ....
  44. ncbi Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity
    Joseph Roitelman
    Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer 52621, Israel
    J Biol Chem 279:6465-73. 2004
    ..This Apomine-enhanced activation of sterol-regulatory element-binding protein-2 was prevented by sterols or mevalonate. Taken together, our results provide a molecular mechanism for the hypocholesterolemic activity of Apomine...
  45. pmc Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIα
    Sangeeta Banerji
    Departments of Pediatrics and Biochemistry and Molecular Biology, Atlantic Research Centre, Dalhousie University, Halifax, NS, Canada
    Mol Biol Cell 21:4141-50. 2010
    ....
  46. ncbi The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols
    B A Janowski
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA
    J Biol Chem 276:45408-16. 2001
    ..LY295427 overcame the suppression of SREBP processing mediated by several oxysterols but not by LDL-derived cholesterol. We conclude that LY295427 achieves a therapeutically desirable end point by an unique mechanism of action...
  47. pmc Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1
    Natalia Mast
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:5607-13. 2011
    ....
  48. ncbi Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry
    Ines Burkard
    Institute of Clinical Chemistry, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Lipid Res 45:776-81. 2004
    ....
  49. ncbi 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols
    Robert J Fakheri
    New York University School of Medicine, NY, USA
    Steroids 77:575-7. 2012
    ..Using this molecule as a starting point, this review hopes to establish a common language to keep all investigators on the same page...
  50. ncbi The detection of 20S-hydroxycholesterol in extracts of rat brains and human placenta by a gas chromatograph/mass spectrometry technique
    Ying Yong Lin
    Department of Obstetrics and Gynecology, The St Luke s Roosevelt Institute for Health Sciences, New York, NY 10019, USA
    J Steroid Biochem Mol Biol 85:57-61. 2003
    ..The possible role of 20(S)-hydroxycholesterol in steroid hormone biosynthesis and in other biological processes is discussed...
  51. pmc The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome
    Yuqin Wang
    Institute of Mass Spectrometry, School of Medicine, Swansea University, Singleton Park, Swansea, SA2 8PP, UK
    J Proteome Res 7:1606-14. 2008
    ..Taken together, this data leads to the hypothesis that, in times of cholesterol excess, 24S-hydroxycholesterols signals down-regulation of cholesterol synthesis enzymes through SREBP-2, but up-regulates apo E synthesis (..
  52. pmc Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling
    Sunita Sharma
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Neurobiol Dis 32:426-32. 2008
    ..We suggest that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 signaling...
  53. pmc 11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol
    Tijana Mitić
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, College of Medicine and Veterinary Medicine, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, Scotland, UK
    Biochimie 95:548-55. 2013
    ..This mechanism may be important in the cardioprotective effects of 11β-HSD1 inhibitors...
  54. ncbi Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples
    Yasukazu Yoshida
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka 563 8577, Japan
    Anal Biochem 379:105-15. 2008
    ..t8-iso-PGF(2alpha), tHODE, tHETE, and t7-OHCh are measured satisfactorily and inclusively by the current method from biological fluids and tissues, and they can account for a large portion of oxidized lipids in vivo...
  55. ncbi Control of apolipoprotein E secretion in the human hepatoma cell line KYN-2
    F Brahimi
    , EA 3117, , 30 rue Lionnois, 54000 Nancy, France
    Cell Biochem Funct 19:51-8. 2001
    ..The response of KYN-2 cells to both cytokines and cholesterol differs from that found in astrocytoma cells, suggesting that blood variations of apoE concentrations in AD may not reflect the dysregulations taking place in the brain...
  56. ncbi Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate
    Leyuan Xu
    Department of Medicine, McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Research 151, 1201 Broad Rock Blvd, Richmond, VA 23249, USA
    Lipids 45:821-32. 2010
    ..The current findings suggest that 25HC and 25HC3S serve as potent regulators in cross-talk of lipid metabolism and inflammatory response in the hepatocytes...
  57. ncbi Regulation of sterol regulatory element-binding proteins by cholesterol flux in CaCo-2 cells
    F J Field
    Department of Internal Medicine, 4 522 JCP, 200 Hawkins Drive, and Veterans Administration, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    J Lipid Res 42:1687-98. 2001
    ..In contrast, 25-hydroxycholesterol influx or cholesterol depletion alters the amount of mature SREBP, leading to the regulation of sterol-responsive gene expression...
  58. ncbi High circulating levels of 7beta- and 7alpha-hydroxycholesterol and presence of apoptotic and oxidative markers in arterial lesions of normocholesterolemic atherosclerotic patients undergoing endarterectomy
    C Prunet
    Laboratoire de Biochimie Medicale, Inserm U498 IFR 100, CHU Hôpital du Bocage, BP 77908, 21079 Dijon Cedex, France
    Pathol Biol (Paris) 54:22-32. 2006
    ..At the arterial level, apoptotic cells were mainly identified in low grade lesions and no statin effects were found on oxidation and apoptosis...
  59. ncbi Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio
    Yvonne Steffen
    Institut fur Biochemie und Molekularbiologie I, Heinrich Heine Universitat, Postfach 101007, D 40001 Dusseldorf, Germany
    Free Radic Biol Med 41:1139-50. 2006
    ..The dietary polyphenol (-)-epicatechin inhibited not only formation but also cytotoxic actions of both oxLDL and oxysterols...
  60. ncbi 25-hydroxycholesterol is produced by testicular macrophages during the early postnatal period and influences differentiation of Leydig cells in vitro
    Jau Jiin Chen
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA
    Biol Reprod 66:1336-41. 2002
    ..These findings support the hypothesis that testicular macrophages play an important role in the differentiation of Leydig cells through the secretion of 25-hydroxycholesterol...
  61. ncbi 25-hydroxycholesterol induces mitochondria-dependent apoptosis via activation of glycogen synthase kinase-3beta in PC12 cells
    Y K Choi
    College of Pharmacy, Seoul National University, Seoul, Republic of Korea
    Free Radic Res 42:544-53. 2008
    ..Pharmacological intervention of GSK-3beta-JNK-caspase signalling pathway may be useful for the reduction of cytotoxicity of oxysterols...
  62. ncbi Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7beta-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals
    Carole Miguet-Alfonsi
    CHU Hôpital du Bocage, Laboratoire de Biochimie Medicale, INSERM U498, BP 1542, 21034 Cedex, Dijon, France
    Biochem Pharmacol 64:527-41. 2002
    ....
  63. ncbi Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers
    Ines Burkard
    Institute of Clinical Chemistry, Center for Integrative Human Physiology, University Hospital Zurich, CH 8091 Zurich, Switzerland
    Atherosclerosis 194:71-8. 2007
    ..Our data on the lipoprotein distribution of oxysterols as well as on their intra- and inter-individual variation set the stage for future clinical studies...
  64. ncbi Cytotoxic effect of 7beta-hydroxycholesterol on human NCI-H460 lung cancer cells
    Kyoung Ah Kang
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Korea
    Biol Pharm Bull 28:1377-80. 2005
    ..7beta-OHC resulted in generation of reactive oxygen species (ROS) during apoptosis. On the whole, the results indicated that 7beta-OHC inhibited the proliferation of NCI-H460 cells through apoptosis via caspase activation...
  65. ncbi Plasma 7beta-hydroxycholesterol as a possible predictor of lung cancer risk
    Jakob Linseisen
    German Cancer Research Centre, Division of Clinical Epidemiology, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 11:1630-7. 2002
    ..Because of the rather high-risk estimate, research on possible intrinsic biological effects of this compound should be encouraged...
  66. pmc Translocation of oxysterol binding protein to Golgi apparatus triggered by ligand binding
    N D Ridgway
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Cell Biol 116:307-19. 1992
    ..We conclude that OSBP is triggered to bind extrinsically to Golgi membranes when it binds oxysterols and speculate that this translocation may play a role in the transport, metabolism, or regulatory actions of oxysterols...
  67. ncbi Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
    Anne Vejux
    DSV DIEP SBTN, Universite de Nice Sophia Antipolis, France
    Mol Aspects Med 30:153-70. 2009
    ..This basic knowledge on oxysterols contributes to a better understanding of the associated pathologies, so that new treatments and drugs can be designed...
  68. ncbi Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
    J M Lehmann
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 272:3137-40. 1997
    ..Our data provide evidence for a new hormonal signaling pathway that activates transcription in response to oxysterols and suggest that LXRs play a critical role in the regulation of cholesterol homeostasis...
  69. ncbi 7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependent
    Stéphanie Lemaire-Ewing
    INSERM U866, Dijon, France
    Cell Biol Toxicol 25:127-39. 2009
    ..These results demonstrate that oxysterol-induced IL-8 secretion is a calcium-dependent phenomenon involving the MEK/ERK1/2 pathway leading to the activation of IL-8 gene via AP-1 (c-fos)...
  70. ncbi Effects of 25-hydroxycholesterol on cholesterol esterification and sterol regulatory element-binding protein processing are dissociable: implications for cholesterol movement to the regulatory pool in the endoplasmic reticulum
    Ximing Du
    School of Biotechnology and Biomolecular Sciences, Biological Sciences Building D26, University of New South Wales, Sydney, 2052, Australia
    J Biol Chem 279:47010-6. 2004
    ..In light of our results, we question the security of previous work that has inferred cholesterol transport to the ER regulatory pool based solely on cholesterol esterification...
  71. ncbi Oxysterols: friends, foes, or just fellow passengers?
    Ingemar Bjorkhem
    Division of Clinical Chemistry, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
    Arterioscler Thromb Vasc Biol 22:734-42. 2002
    ..The present review is a critical evaluation of the literature on oxysterols, in particular, the in vivo evidence for a role of oxysterols as physiological regulators of cholesterol homeostasis and as atherogenic factors...
  72. ncbi 25-hydroxycholesterol induces lipopolysaccharide-tolerance and decreases a lipopolysaccharide-induced TNF-alpha secretion in macrophages
    M C Englund
    The Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, SE 413 45 Goteborg, Sweden
    Atherosclerosis 158:61-71. 2001
    ..In vitro studies of the TNF-alpha promoter suggests possible interactions between Sp1 and Sp3 and the NF-kappaB transcription factor complex that might affect the transcriptional initiation...
  73. pmc LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes
    B A Laffitte
    Howard Hughes Medical Institute, Department of Pathology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 98:507-12. 2001
    ..Together with our previous work, these findings support a central role for LXR signaling pathways in the control of macrophage cholesterol efflux through the coordinate regulation of apoE, ABCA1, and ABCG1 expression...
  74. ncbi The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one
    L Liscum
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111
    J Biol Chem 264:11796-806. 1989
    ..Analysis of intracellular cholesterol transport reveals that LDL-derived cholesterol accumulates in the lysosomes of U18666A-treated CHO cells which results in impaired movement of LDL-derived cholesterol to other cell membranes...
  75. ncbi Induction of apoptosis by 25-hydroxycholesterol in adult rat Leydig cells: protective effect of 17beta-estradiol
    Carine Travert
    Biochemistry Laboratory EA 2608 USC INRA 2006, IBFA, University of Caen, Esplanade de la Paix, 14302 Caen Cedex, France
    Reprod Toxicol 22:564-70. 2006
    ..These data suggested that this oxysterol can be used by rat Leydig cells in culture for sterol metabolism, but also induces apoptosis which could be inhibited by 17beta-estradiol...
  76. ncbi 25-Hydroxycholesterol has a dual effect on the proliferation of cultured rat astrocytes
    Esther Velázquez
    Department of Biochemistry and Molecular Biology III, Faculty of Medicine, Complutense University, 28040 Madrid, Spain
    Neuropharmacology 51:229-37. 2006
    ..This could be of interest for gaining a better knowledge of the pathophysiological processes occurring in these cells...
  77. pmc 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway
    Yongjie Ma
    Veterans Affairs McGuire Medical Center Virginia Commonwealth University, Richmond, VA 23249, USA
    Am J Physiol Endocrinol Metab 295:E1369-79. 2008
    ..We conclude that 25HC3S acts in macrophages as a cholesterol satiety signal, downregulating cholesterol and fatty acid synthetic pathways via inhibition of LXR/SREBP signaling. A possible role of oxysterol sulfation is proposed...
  78. ncbi Changes in human plasma levels of the brain specific oxysterol 24S-hydroxycholesterol during progression of multiple sclerosis
    Valerio Leoni
    Department of Experimental and Clinical Biomedical Science DSBSC, University of Insubria, Varese, Italy
    Neurosci Lett 331:163-6. 2002
    ..The possibility is discussed that plasma levels of 24S-OH-chol may add significantly to existing methods used for evaluation of the different phases of multiple sclerosis...
  79. ncbi Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis
    A Vejux
    Unité Transporter in Imaging and Radiotherapy in Oncology, Commissariat a l Energie Atomique, DSV DIEP SBTN, Faculte de Medicine, Universite de Nice Sophia Antipolis, Nice, France
    Braz J Med Biol Res 41:545-56. 2008
    ....
  80. ncbi Role of p160 coactivator complex in the activation of liver X receptor
    Jarkko Huuskonen
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Arterioscler Thromb Vasc Biol 24:703-8. 2004
    ..In this study, we have investigated the role of p160 coactivator complex in the regulation of ATP-binding transporter A1 (ABCA1), a clinically important gene transcriptionally upregulated by LXR/RXR (retinoid X receptor) heterodimer...
  81. ncbi Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 368:303-8. 2004
    ..Our results support the observation, that cholesterol metabolism is altered in dementing disorders, indicated by different plasma concentrations of brain specific and peripherally produced oxysterols...
  82. ncbi Origin of oxysterols in hepatic bile of patients with biliary infection
    Tadashi Yoshida
    Division of Gastroenterology, Tsukuba Memorial Hospital and Institute of Clinical Medicine, University of Tsukuba, Japan
    Am J Gastroenterol 98:2275-80. 2003
    ..The purpose of this study was to determine if infection of the biliary tract was associated with increased concentrations of oxysterols in the bile and, if so, which oxysterols showed a significant change...
  83. ncbi Serum cholesterol, precursors and metabolites and cognitive performance in an aging population
    C E Teunissen
    European Graduate School of Neuroscience EURON, Universiteit Maastricht, Maastricht, The Netherlands
    Neurobiol Aging 24:147-55. 2003
    ..Thus, relative high serum ratios of the cholesterol precursors lanosterol and lathosterol, indicative for a high rate of endogenous cholesterol synthesis, are associated with relatively low memory performance in this aging population...
  84. pmc 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling
    Carolyn D DuSell
    Duke University Medical Center, Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA
    Trends Pharmacol Sci 29:510-4. 2008
    ..These results provide an interesting potential link between cholesterol (and cholesterol metabolism) and ER function, the physiological and pathological importance of which remains to be determined...
  85. ncbi Production of 25-hydroxycholesterol by testicular macrophages and its effects on Leydig cells
    Y O Lukyanenko
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Biol Reprod 64:790-6. 2001
    ....
  86. ncbi Oxysterols: functional significance in fetal development and the maintenance of normal retinal function
    Norman B Javitt
    New York University School of Medicine, New York, New York, USA
    Curr Opin Lipidol 18:283-8. 2007
    ..Recent findings extend the biologic activities of oxysterols as ligands for nuclear receptors to a role in morphogenesis during fetal development and to a role in the metabolism of photooxidation products of cholesterol in the retina...
  87. ncbi Hypoxia increases 25-hydroxycholesterol-induced interleukin-8 protein secretion in human macrophages
    Ellen Knutsen Rydberg
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, Goteborg University, SE 41345 Goteborg, Sweden
    Atherosclerosis 170:245-52. 2003
    ..Thus, hypoxia in atherosclerotic plaques may increase the secretion of IL-8 from oxysterol-containing foam cells, which subsequently may accelerate the progression of atherosclerosis...
  88. ncbi Oxysterol mixtures prevent proapoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation
    Fiorella Biasi
    Department of Clinical and Biological Sciences, University of Torino, S Luigi Gonzaga Hospital, Torino, Italy
    FASEB J 18:693-5. 2004
    ..As a consequence, a more subtle gene modulation by oxysterols becomes facilitated in vascular cells...
  89. ncbi Control of apolipoprotein E secretion by 25-hydroxycholesterol and proinflammatory cytokines in the human astrocytoma cell line CCF-STTG1
    Y Gueguen
    INSERM U525 (Equipe 4, , , Nancy, France
    Cell Biol Toxicol 17:191-9. 2001
    ..Surprisingly, oxysterols would be able to limit this phenomenon...
  90. pmc Liquid chromatography-tandem mass spectrometry determination of plasma 24S-hydroxycholesterol with chromatographic separation of 25-hydroxycholesterol
    Andrea E DeBarber
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Anal Biochem 381:151-3. 2008
    ..The availability of an LC-MS method offers advantages such as simplified sample work-up and analysis...
  91. ncbi Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease
    Alina Solomon
    Department of Neurology, University of Kuopio, Kuopio, Finland
    Neurosci Lett 462:89-93. 2009
    ..This study investigates the relation of 24OHC as well as markers of extracerebral cholesterol homeostasis (lanosterol, lathosterol, cholesterol, LDL-C, HDL-C and 27-hydroxycholesterol) with brain volumes in memory clinic patients...
  92. pmc Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols
    D S Lala
    Departments of Orphan Nuclear Receptor and Retinoid Research, Ligand Pharmaceuticals, 10255 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 94:4895-900. 1997
    ..Finally, ligand-dependent transactivation of SF-1 by oxysterols may play an important role in enhancing steroidogenesis in vivo...
  93. ncbi Oxysterols enhance osteoblast differentiation in vitro and bone healing in vivo
    Tara L Aghaloo
    Division of Diagnostic and Surgical Sciences, University of California at Los Angeles School of Dentistry, Room 53 068 CHS, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Orthop Res 25:1488-97. 2007
    ..These results identify oxysterols as potential agents in local and systemic enhancement of bone formation...
  94. pmc Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle
    Othman Ghribi
    Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, ND 58202, USA
    J Alzheimers Dis 15:673-84. 2008
    ..We also have found pathological hallmarks in the skeletal muscle of cholesterol-fed rabbits that are suggestive of inclusion body myositis, a disease that shares some pathological similarities with AD...
  95. ncbi Oxysterol-induced toxicity in R28 and ARPE-19 cells
    John M Ong
    Molecular Eye Research Laboratory, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Neurochem Res 28:883-91. 2003
    ..These in vitro findings provide evidence that cholesterol oxides can directly damage cultured retinal and RPE cells. The oxysterol-induced oxidative stress in these cells may be a factor in the pathology of retinal degenerative diseases...
  96. ncbi The role of 24S-hydroxycholesterol in Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Nutr Health Aging 7:37-41. 2003
    ..This review will give a brief overview on the relevance of 24S-hydroxycholesterol as a possible risk factor and diagnostic state marker for AD...
  97. ncbi Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells
    Corinne Joffre
    Eye and Nutrition Research Group, INRA, UMR1129 FLAVIC, Dijon, France
    Curr Eye Res 32:271-80. 2007
    ..We investigated the effects of three oxysterols on mitochondrial dysfunctions, inflammation, and oxidative stress in primary cultures of porcine retinal pigment epithelial (RPE) cells...
  98. ncbi Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells
    Valérie Riendeau
    Centre de recherche sur les maladies lipidiques, Centre hospitalier universitaire de Quebec Centre de recherche du centre hospitalier de l Universite Laval, Universite Laval, Quebec, QC, Canada
    Free Radic Res 43:1019-28. 2009
    ..All together, cell survival triggered by LXRs is impaired in the presence of cholesterol or high concentrations of 27-OH in human U937 macrophages and is not effective in HASMC...
  99. ncbi Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols
    S Lemaire-Ewing
    INSERM U498, Métabolisme des Lipoprotéines Humaines et Interactions Vasculaires, CHU Hôpital du Bocage, Dijon, France
    Cell Biol Toxicol 21:97-114. 2005
    ..None of the effects observed for the oxysterols were detected for cholesterol. Therefore, oxysterols may have cytotoxic, oxidative, and/or inflammatory effects, or none whatsoever...
  100. ncbi A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors
    Michael Albers
    PheneX Pharmaceuticals AG, 67056 Ludwigshafen, Germany and Department of Vascular and Metabolic Diseases, F Hoffmann La Roche AG, 4070 Basel, Switzerland
    J Biol Chem 281:4920-30. 2006
    ..Our data show how competitive binding of coactivators and corepressors can explain the tissue-specific behavior of partial agonists and open up new routes to a rational design of partial agonists for LXRs...
  101. ncbi Toxicity of cholesterol oxides on cultured neuroretinal cells
    J Y Chang
    Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Curr Eye Res 17:95-103. 1998
    ....

Research Grants24

  1. MACROPHAGE DERIVED FACTOR AND LEYDIG CELL FUNCTION
    JAMES HUTSON; Fiscal Year: 2001
    ..abstract_text> ..
  2. The pharmacological actions of antiprogestins in uterine fibroids
    Donald P McDonnell; Fiscal Year: 2010
    ..abstract_text> ..
  3. Regulation of Bile Acid Synthesis by Nuclear Receptors
    John Y L Chiang; Fiscal Year: 2010
    ..This study could contribute to understanding the mechanisms of metabolic diseases caused by dysregulation of bile acid synthesis and develop therapeutic agents to treat dyslipidemia, liver diseases, obesity and type II diabetes. ..
  4. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..
  5. Fetal Origin of Male Reproductive Disorders
    Vassilios Papadopoulos; Fiscal Year: 2009
    ....
  6. ACUTE HORMONAL REGULATION OF STEROIDOGENESIS
    Vassilios Papadopoulos; Fiscal Year: 2008
    ..Data generated from these studies should test our hypothesis that a mitochondrial cAMP signaling complex (transduceosome) directs and amplifies the effects of cAMP leading to the induction and maintenance of steroidogenesis. ..
  7. Role of Egr-1 in Corpus Luteum Function
    John Davis; Fiscal Year: 2006
    ..abstract_text> ..
  8. Attenuating sterol synthesis in WT and NPC mice brains
    Ta Yuan Chang; Fiscal Year: 2005
    ..Specific Aim 3: To examine the long-term effect of SSI CP-340868 at 2 different doses on life spans of normal and NPC1 mice. ..
  9. IGF-I SIGNALING IN GRANULOSA CELLS
    John Davis; Fiscal Year: 2004
    ..This new insight may uncover mechanistic defects that underlay disorders of folliculogenesis, premature ovarian failure and disorders such as polycystic ovarian syndrome. ..
  10. Development of peptide antagonists of estrogen signaling
    Donald McDonnell; Fiscal Year: 2005
    ..In particular, we see that this approach would be applicable to the treatment of anti-androgen resistant prostate cancers where receptor mutations enable the inappropriate recruitment of transcription coactivators. ..
  11. Role of Benzodiazepine Receptor in Leydig Cell Function
    Vassilios Papadopoulos; Fiscal Year: 2011
    ....
  12. Fourteenth Ovarian Workshop
    John Davis; Fiscal Year: 2002
    ..New investigators will be invited to submit expanded abstracts that will be evaluated for scientific merit and competition for travel awards and the Cornelia P. Channing New Investigator Award. ..
  13. Fifteenth Ovarian Workshop
    John Davis; Fiscal Year: 2004
    ..New investigators will be invited to submit expanded abstracts that will be evaluated for scientific merit and competition for travel awards and the Cornelia P. Channing New Investigator Award. ..
  14. Dual Energy X-Ray Absorptiometer (QDR4500A)
    Frances Tylavsky; Fiscal Year: 2003
    ..It is within the existing structure and function of the GCRC that the administrative and scientific oversight of this DXA will be managed. ..
  15. MECHANISM OF ESTROGENS AND ANTIESTROGENS
    Donald McDonnell; Fiscal Year: 2004
    ..abstract_text> ..
  16. Conference on Tissue-Selective Nuclear Receptors
    Donald McDonnell; Fiscal Year: 2004
    ..The meeting will center upon our understanding of a class of transcription factors whose pharmacology touches some of the most prevalent human diseases ..
  17. ABCA1: A Potential Therapeutic Target for AD
    Radosveta Koldamova; Fiscal Year: 2006
    ..abstract_text> ..
  18. Nuclear Receptors: Steroid Sisters
    Donald McDonnell; Fiscal Year: 2004
    ..abstract_text> ..
  19. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  20. Molecular Determinants of Androgen Receptor Pharmacology
    Donald McDonnell; Fiscal Year: 2006
    ..abstract_text> ..
  21. GENETIC DISSECTION OF PROGESTERONE RECEPTOR FUNCTION
    Donald McDonnell; Fiscal Year: 2004
    ..3) Definition of the molecular mechanism of action of the selective progesterone receptor modulators (SPRMs). (4) Identification of cellular factors which modulate PR-pharmacology. ..
  22. Mineralization studies related to atherosclerosis
    HOWARD HSU; Fiscal Year: 2004
    ..abstract_text> ..
  23. MOLECULAR STUDIES OF EUKARYOTIC CELL SURFACE GROWTH
    Randy Schekman; Fiscal Year: 2005
    ..A mechanistic appreciation of the details of vesicle traffic in yeast will also illuminate the pathology of human diseases that impinge on the secretory pathway. ..