dietary cholesterol

Summary

Summary: Cholesterol present in food, especially in animal products.

Top Publications

  1. ncbi Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol
    E Sarkkinen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Am J Clin Nutr 68:1215-22. 1998
  2. ncbi Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    Kristiaan Wouters
    Department of Molecular Genetics, Physiology and Electron Microscopy Unit, Nutrition and Toxicology Research and Cardiovascular Research, Institutes of Maastricht University, Maastricht, The Netherlands
    Hepatology 48:474-86. 2008
  3. ncbi Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis
    R M Weggemans
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 73:885-91. 2001
  4. ncbi Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease
    Maria Vinaixa
    Metabolomics Platform, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, IISPV, Universitat Rovira i Virgili, Avda Països Catalans 26, 43007 Tarragona, Spain
    J Proteome Res 9:2527-38. 2010
  5. pmc Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization
    Heather M Alger
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 285:14267-74. 2010
  6. ncbi Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol
    H Gullberg
    Laboratory of Developmental Biology, Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Mol Endocrinol 14:1739-49. 2000
  7. pmc Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice
    Savitha Subramanian
    Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Arterioscler Thromb Vasc Biol 28:685-91. 2008
  8. ncbi Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient mice
    Monica Tous
    Centre de Recerca Biomedica, Institut de Recerca en Ciències de la Salut IRCIS, Hospital Universitari de Sant Joan, Calle Sant Joan s n, 43201 Reus, Spain
    Biochem Biophys Res Commun 340:1078-84. 2006
  9. ncbi Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues
    Ikuyo Ichi
    Department of Food Science and Nutrition, Nara Women s University, Nara, Japan
    Nutrition 23:570-4. 2007
  10. ncbi Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism
    Hyoun ju Kim
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA
    J Lipid Res 43:1750-7. 2002

Research Grants

Detail Information

Publications224 found, 100 shown here

  1. ncbi Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol
    E Sarkkinen
    Department of Clinical Nutrition, University of Kuopio, Finland
    Am J Clin Nutr 68:1215-22. 1998
    ..The magnitude of the influence of the apolipoprotein (apo) E genotype on the lipid response to different cholesterol-lowering diet modifications has been controversial...
  2. ncbi Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    Kristiaan Wouters
    Department of Molecular Genetics, Physiology and Electron Microscopy Unit, Nutrition and Toxicology Research and Cardiovascular Research, Institutes of Maastricht University, Maastricht, The Netherlands
    Hepatology 48:474-86. 2008
    ..The role of steatosis and dietary cholesterol in the etiology of diet-induced NASH was investigated using hyperlipidemic mouse models fed a Western diet...
  3. ncbi Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis
    R M Weggemans
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 73:885-91. 2001
    ..OBJECTIVE: The objective was to review the effect of dietary cholesterol on the ratio of total to HDL cholesterol...
  4. ncbi Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease
    Maria Vinaixa
    Metabolomics Platform, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, IISPV, Universitat Rovira i Virgili, Avda Països Catalans 26, 43007 Tarragona, Spain
    J Proteome Res 9:2527-38. 2010
    ..b>Dietary cholesterol increased the hepatic concentrations of cholesterol, triglycerides, and oleic acid but also decreased the [..
  5. pmc Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization
    Heather M Alger
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 285:14267-74. 2010
    ..lipid (TG and cholesteryl ester) accumulation, with the greatest differences occurring in situations where dietary cholesterol was elevated...
  6. ncbi Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol
    H Gullberg
    Laboratory of Developmental Biology, Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Mol Endocrinol 14:1739-49. 2000
    ..contribution of thyroid hormone receptors (TR) alpha1 and beta in this regulation, the responses to 2% dietary cholesterol and T3 were studied in TRalpha1 and TRbeta knockout mice under hypo- and hyperthyroid conditions...
  7. pmc Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice
    Savitha Subramanian
    Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
    Arterioscler Thromb Vasc Biol 28:685-91. 2008
    Chronic systemic inflammation accompanies obesity and predicts development of cardiovascular disease. Dietary cholesterol has been shown to increase inflammation and atherosclerosis in LDL receptor-deficient (LDLR(-/-)) mice...
  8. ncbi Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient mice
    Monica Tous
    Centre de Recerca Biomedica, Institut de Recerca en Ciències de la Salut IRCIS, Hospital Universitari de Sant Joan, Calle Sant Joan s n, 43201 Reus, Spain
    Biochem Biophys Res Commun 340:1078-84. 2006
    ..Both tissues respond in a similar way when dietary cholesterol is provided for a few weeks but differently if the conditions persist for a protracted period of time...
  9. ncbi Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues
    Ikuyo Ichi
    Department of Food Science and Nutrition, Nara Women s University, Nara, Japan
    Nutrition 23:570-4. 2007
    ..In addition, we found a relation among lipid markers of atherosclerosis such as cholesterol, triacylglycerol, and ceramide concentrations...
  10. ncbi Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism
    Hyoun ju Kim
    Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA
    J Lipid Res 43:1750-7. 2002
    ..This study demonstrates that cholesterol overrides the PUFA-mediated repression of the SCD1 gene and regulates SCD1 gene expression through a mechanism independent of SREBP-1 maturation...
  11. pmc Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice
    S Alberti
    Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
    J Clin Invest 107:565-73. 2001
    ..mouse lines with targeted disruptions of each of these LXR receptors and have compared their responses to dietary cholesterol. Serum and hepatic cholesterol levels and lipoprotein profiles of cholesterol-fed animals revealed no ..
  12. ncbi Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in mice
    Katherine E Lewis
    Department of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
    Circulation 110:540-5. 2004
    ..Therefore, we hypothesized that diet-induced increases in SAA would increase atherosclerosis independent of their effect on plasma cholesterol levels...
  13. ncbi Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxide
    Karen Y Stokes
    Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130 3932, USA
    Free Radic Biol Med 33:1026-36. 2002
    ..Agents that act to maintain the normal balance between NO and reactive oxygen species (ROS) in vascular endothelial cells may prove particularly useful in this regard...
  14. ncbi Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: a randomized clinical trial
    Janette Khoury
    Department of Obstetrics and Gynecology, National University Hospital, Oslo, Norway
    Am J Obstet Gynecol 193:1292-301. 2005
    ..We assessed the effect of a cholesterol-lowering diet on maternal, cord, and neonatal plasma lipids and pregnancy outcome...
  15. ncbi Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    K E Berge
    Department of Molecular Genetics and McDermott Center for Human Growth and Development and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 290:1771-5. 2000
    ..These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis...
  16. ncbi Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    J Am Coll Nutr 21:250-8. 2002
    ..However, the impact of excess dietary cholesterol intake on plasma cholesterol levels cannot be accurately predicted; therefore, its role in disease ..
  17. ncbi Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice
    Nadya Khan-Merchant
    Nutrition and Health Sciences Program, Division of Biological and Biomedical Sciences, and Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 132:3256-62. 2002
    ..05). Our results suggest that, in mice fed cholesterol, oxidized fatty acids may be atherogenic, both in terms of increased oxidative stress (as seen in study 1) and by increasing the atherogenicity of the plasma cholesterol profile...
  18. ncbi APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's disease
    Hafiz Mohmmad Abdul
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Neurosci Lett 368:148-50. 2004
    ..the brain homogenates from knock-in mice expressing mutant human PS-1 and APP in relation to the intake of dietary cholesterol. The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid ..
  19. pmc Egg consumption and risk of type 2 diabetes in men and women
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:295-300. 2009
    Whereas limited and inconsistent findings have been reported on the relation between dietary cholesterol or egg consumption and fasting glucose, no previous study has examined the association between egg consumption and type 2 diabetes...
  20. ncbi ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens
    Jacob D Mulligan
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 278:13356-66. 2003
    ..0- and 4.4-fold, respectively), whereas biliary lipid concentrations were unaltered by the WHAM mutation. In summary, ABCA1 regulates the efflux of cholesterol from the basolateral but not apical membrane in the intestine and the liver...
  21. pmc Dietary cholesterol plays a role in CD36-mediated atherogenesis in LDLR-knockout mice
    David J Kennedy
    Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 29:1481-7. 2009
    ..We observed no difference in aortic lesion area between Western diet (WD)-fed LDLR(o) and LDLR(o)/CD36(o) mice. The objective was to understand the mechanism of CD36-dependent atherogenesis...
  22. ncbi Dietary fat and incidence of type 2 diabetes in older Iowa women
    K A Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 24:1528-35. 2001
    ..CONCLUSIONS: These data support an inverse relation between incident type 2 diabetes and vegetable fat and substituting polyunsaturated fatty acids for saturated fatty acids and cholesterol...
  23. ncbi Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27 Kip1 -independent pathway
    Claudia Castro
    Laboratorio de Biología Vascular, Departamento de Patología y Terapia Molecular y Celular, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas, C Jaime Roig 11, 46010, Valencia, Spain
    Atherosclerosis 172:31-8. 2004
    ..Our results suggest that rapamycin-dependent atheroprotection occurs through a p27(Kip1)-independent pathway that involves reduced expression of positive cell cycle regulators and MCP-1 within the arterial wall...
  24. ncbi The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    J Nutr 136:1161-5. 2006
    The ATP binding cassette G5 (ABCG5) polymorphisms have been postulated to play a role in the response to dietary cholesterol. The objective of this study was to examine the contribution of the ABCG5 polymorphism on the plasma response to ..
  25. ncbi Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats
    Makoto Asahina
    Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Lipid Res 50:41-6. 2009
    ..identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary ..
  26. ncbi Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behavior
    Wilson G Pond
    USDA Agricultural Research Service, Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Nutr 138:282-6. 2008
    ..designed to test the effect of polymorphism in the cholesterol 7-alpha hydroxylase (CYP7) gene locus and dietary cholesterol (C) on cerebrum C in neonatal pigs fed sow's milk formulas...
  27. ncbi Lipoprotein metabolism in the fat Zucker rat: reduced basal expression but normal regulation of hepatic low density lipoprotein receptors
    W Liao
    Center for Nutrition and Toxicology, Novum, Department of Medicine, Karolinska Institute at Huddinge University Hospital, Sweden
    Endocrinology 138:3276-82. 1997
    ..Challenge with 2% dietary cholesterol for 8 days suppressed hepatic LDL receptor expression in lean animals to similar levels as seen in fat ones,..
  28. ncbi The lipoprotein/lipid profile is modulated by a gene-diet interaction effect between polymorphisms in the liver X receptor-alpha and dietary cholesterol intake in French-Canadians
    Julie Robitaille
    Lipid Research Center, CHUQ CHUL, Ste Foy, Quebec, Canada
    Br J Nutr 97:11-8. 2007
    ..0 mmol/l) and LDL-cholesterol (>3.5 mmol/l) concentrations. dietary cholesterol was obtained from a food-frequency questionnaire. The LXRalpha c.-115G>A, c.-840C>A and c...
  29. ncbi Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do not
    Lawrence L Rudel
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 277:31401-6. 2002
    ..the principal ACAT enzyme within primate hepatocytes, as a regulator of the hypercholesterolemia induced by dietary cholesterol was studied...
  30. ncbi Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogs
    Mohammad Z Abedin
    Department of Surgery, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA
    Dig Dis Sci 47:2192-210. 2002
    ..These data suggest that lovastatin therapy alone may promote gallstone dissolution in humans...
  31. pmc Dietary cholesterol and egg yolks: not for patients at risk of vascular disease
    J David Spence
    Stroke Prevention and Atheroschlerosis Research Centre, Robarts Research Institute, London, Ontario
    Can J Cardiol 26:e336-9. 2010
    ..It is increasingly believed that consumption of dietary cholesterol and egg yolks is harmless...
  32. ncbi Effects of dietary cholesterol and fat on serum non-cholesterol sterols according to different apolipoprotein E subgroups among healthy men
    Markku J Nissinen
    Division of Gastroenterology, Department of Medicine, University of Helsinki, C422, POB 700, Helsinki FI 00029, Finland
    Br J Nutr 100:373-9. 2008
    ..Surrogate sterol markers of cholesterol metabolism reflected absolute ones (especially in the apo E4 group) and apo E phenotypes despite variable amounts of dietary cholesterol and fat.
  33. ncbi Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations
    D L Sparks
    Sun Health Research Institute, Sun City, Arizona, USA
    Ann N Y Acad Sci 903:335-44. 2000
    ..b>Dietary cholesterol induced a twofold increase in beta-amyloid concentration in rabbit hippocampal cortex, which may be related ..
  34. ncbi Response of plasma lipids to dietary cholesterol and wine polyphenols in rats fed polyunsaturated fat diets
    L Fremont
    Laboratoire de Nutrition et Securite Alimentaire, INRA CRJ, Jouy en Josas, France
    Lipids 35:991-9. 2000
    ..0001). However, the cholesterol content of liver microsomes was not affected. Dietary cholesterol altered the distribution of fatty acids mainly by reducing the ratio of arachidonic acid to linoleic acid (..
  35. ncbi Dietary cholesterol suppresses the ability of olive oil to delay the development of atherosclerotic lesions in apolipoprotein E knockout mice
    Sergio Acin
    Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain
    Atherosclerosis 182:17-28. 2005
    ..They also suggest that the mere inclusion of olive oil in Western diets is insufficient and the adoption of Mediterranean diet would be more effective in retarding the development of atherosclerotic lesions...
  36. ncbi Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
    Atherosclerosis 161:85-94. 2002
    ....
  37. ncbi In vitro effect of cholesterol on calcifying activity of vesicles isolated from rabbit aortas
    Howard H T Hsu
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
    Biochim Biophys Acta 1638:235-40. 2003
    ..Altogether, these observations suggest that cholesterol and especially its oxidized forms may induce aortic calcification by directly enhancing the vesicle's ability to calcify...
  38. ncbi Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis
    Monica Tous
    Centre de Recerca Biomedica, Institut de Recerca en Ciències de la Salut, Hospital Universitari de Sant Joan, 43201 Reus, Catalunya, Spain
    Mol Cell Biochem 268:53-8. 2005
    ..We conclude that apolipoprotein E-knockout mice may be a useful model for investigating the mechanisms of diet-induced steatohepatitis...
  39. ncbi Liver copper content of rats hypo- or hyperresponsive to dietary cholesterol
    Ingeborg de Wolf
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands
    J Trace Elem Med Biol 17:177-82. 2003
    ..One strain was dietary cholesterol resistant (SHR/OlaIpcv), whereas the other strain was susceptible to dietary cholesterol (BN-Lx/Cub)...
  40. ncbi Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys
    A K Bhattacharyya
    Department of Pathology, Louisiana State University Medical Center, New Orleans 70112
    Atherosclerosis 67:33-9. 1987
    ..The results also suggest that there might be a lower sensitivity in the feedback inhibition mechanism of cholesterol biosynthesis in the high-responding than in the low-responding rhesus monkeys...
  41. ncbi Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice
    Luis B Agellon
    Department of Biochemistry and Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 277:20131-4. 2002
    b>Dietary cholesterol has been shown to have a stimulatory effect on the murine cholesterol 7alpha-hydroxylase gene (Cyp7a1), but its effect on human cholesterol 7alpha-hydroxylase gene (CYP7A1) expression in vivo is not known...
  42. ncbi Dietary cholesterol modulates delta6 and delta9 desaturase mRNAs and enzymatic activity in rats fed a low-eFA diet
    Rodolfo R Brenner
    Instituto de Investigaciones Bioquimicas de La Plata, CONICET UNLP, Facultad de Ciencias Medicas, Argentina
    Lipids 37:375-83. 2002
    ..Taken together, these results indicate that through its modulating effect on the desaturases, dietary cholesterol may lead an animal or human fed low-EFA diet to a true deficiency by the decreased synthesis of the highly ..
  43. ncbi Cholesterol and copper in the liver of rabbit inbred strains with differences in dietary cholesterol response
    Ingeborg D de Wolf
    Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands
    J Nutr Biochem 14:459-65. 2003
    ..One strain was not reactive to dietary cholesterol (IIIVO/JU), whereas the other strain was reactive to dietary cholesterol (AX/JU)...
  44. ncbi Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
    D F Jelinek
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 265:8190-7. 1990
    ..b>Dietary cholesterol led to an increase in 7 alpha-hydroxylase mRNA levels...
  45. ncbi Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6
    Candace M Kammerer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 22:1720-5. 2002
    ..a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map.
  46. ncbi Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated
    Guorong Xu
    Gastrointestinal Lab 15A Veterans Affairs Medical Center, 385 Tremont Ave, East Orange, NJ 07018 1095, USA
    Am J Physiol Gastrointest Liver Physiol 286:G730-5. 2004
    ..To clarify the mechanism responsible for the upregulation of CYP7A1 in cholesterol-fed rats, the effects of dietary cholesterol (Ch) and cholic acid (CA) on the activation of the nuclear receptors, liver X-receptor (LXR-alpha) and ..
  47. pmc Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult men
    Gisella Mutungi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, 06269 USA
    Lipids Health Dis 6:34. 2007
    ..Subjects were randomly assigned to either EGG (640 mg/d additional dietary cholesterol) or SUB groups [equivalent amount of egg substitute (0 dietary cholesterol contributions) per day] for 12 ..
  48. pmc High dietary cholesterol facilitates classical conditioning of the rabbit's nictitating membrane response
    Bernard G Schreurs
    Department of Physiology and Pharmacology, West Virginia University, Blanchette Rockefeller Neurosciences Institute, Morgantown, WV, USA
    Nutr Neurosci 10:31-43. 2007
    Studies have shown that modifying dietary cholesterol may improve learning and that serum cholesterol levels can be positively correlated with cognitive performance. Rabbits fed a 0, 0.5, 1 or 2% cholesterol diet for eight weeks and 0...
  49. ncbi Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasks
    Vincenzo Micale
    Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy
    Eur Neuropsychopharmacol 18:462-71. 2008
    ..However, evidence for an influence of dietary cholesterol on behavioral models is poor...
  50. pmc Classical conditioning of the rabbit's nictitating membrane response is a function of the duration of dietary cholesterol
    Bernard G Schreurs
    Department of Physiology and Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University, Morgantown, WV, USA
    Nutr Neurosci 10:159-68. 2007
    Modifying dietary cholesterol may improve learning and memory but very high cholesterol can cause pathophysiology and death. Rabbits fed 2% cholesterol for 8, 10 or 12 weeks with 0...
  51. pmc Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levels
    Deya S Darwish
    Department of Neurobiology and Anatomy, Blanchette Rockefeller Neurosciences Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Behav Neurosci 124:115-23. 2010
    ..We show that dietary cholesterol had an adverse effect on memory recall...
  52. ncbi Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidity
    Michio Hashimoto
    Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane 693 8501, Japan
    Mol Cell Biochem 293:1-8. 2006
    ..These results suggest that DHA is a more potent membrane-fluidizer than EPA in withstanding cholesterol-induced decreases in platelet membrane fluidity and a stronger ameliorative modulator of platelet hyperaggregation...
  53. ncbi Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolase
    B R Krause
    Department of Vascular and Cardiac Diseases, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Lipids 33:489-98. 1998
    ..that WAY-121,898 inhibits more than just the intestinal (lumenal) pCEH, and that the role of this enzyme in cholesterol metabolism may be different within and across species, the former depending upon the dietary cholesterol load.
  54. ncbi Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterol
    Kenichiro Yasutake
    Dietetic Laboratory, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
    Scand J Gastroenterol 44:471-7. 2009
    ..The purpose of this study was to identify potential nutritive factors that affect NAFLD and its related nutritional problems...
  55. ncbi Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosis
    Lan Wu
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA
    J Lipid Res 47:2215-22. 2006
    ..Our data suggest that when lipoprotein profiles are similar, addition of fat to a cholesterol-rich diet does not increase atherosclerotic lesion formation in Ldlr(-/-) mice...
  56. pmc Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption
    M H Lee
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Nat Genet 27:79-83. 2001
    The molecular mechanisms regulating the amount of dietary cholesterol retained in the body, as well as the body's ability to exclude selectively other dietary sterols, are poorly understood...
  57. pmc Effects of dietary cholesterol and simvastatin on cholesterol synthesis in Smith-Lemli-Opitz syndrome
    Yen Ming Chan
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Res 65:681-5. 2009
    ..However, the effect of dietary cholesterol and simvastatin on cholesterol synthesis in SLOS has not been reported...
  58. ncbi Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice
    P N Howles
    Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
    J Biol Chem 271:7196-202. 1996
    ..These results indicate that cholesterol esterase is responsible for mediating intestinal absorption of cholesteryl esters but does not play a primary role in free cholesterol absorption...
  59. ncbi Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis
    Heather Basciano
    Department of Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
    Am J Physiol Endocrinol Metab 297:E462-73. 2009
    Although the atherogenic role of dietary cholesterol has been well established, its diabetogenic potential and associated metabolic disturbances have not been reported...
  60. ncbi Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjects
    Lisa R Tannock
    Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 6426, USA
    Circulation 111:3058-62. 2005
    Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known.
  61. ncbi Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet
    Gisella Mutungi
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 138:272-6. 2008
    ..Increasing intake of dietary cholesterol from eggs in the context of a low-fat diet maintains the LDL cholesterol (LDL-C)/HDL-C for both hyper- and ..
  62. ncbi Increased dietary cholesterol enhances cold tolerance in Drosophila melanogaster
    Scott M Shreve
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Cryo Letters 28:33-7. 2007
    ..7+/-4.4 percent) compared to flies on a control diet (20.0+/-2.9 percent). These results suggest a mechanistic link between protection from chilling or cold shock injury and modifications to the cellular membrane...
  63. ncbi Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: effects of dietary cholesterol and phytosterols
    M H Moghadasian
    Department of Pathology and Laboratory Medicine, St Paul s Hospital and University of British Columbia, Vancouver, Canada
    Lab Invest 79:355-64. 1999
    ....
  64. ncbi The effect of ingestion of egg on the serum lipid profile of healthy young Indians
    Gayatri Chakrabarty
    Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029
    Indian J Physiol Pharmacol 48:286-92. 2004
    ..However, since up to one-third of the population may be hyperresponders, knowing the response of an individual is important before making the egg a regular item of the diet...
  65. ncbi Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterol
    E Malle
    Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University, Graz, A 8010, Austria
    Biochem Biophys Res Commun 289:894-900. 2001
    ..We propose that monocyte-derived MPO could connect chronic inflammatory conditions with arterial lipid/lipoprotein deposition during diet-induced atherogenesis in rabbits...
  66. ncbi Eggs and heart disease risk: perpetuating the misperception
    Donald J McNamara
    Am J Clin Nutr 75:333-5. 2002
  67. ncbi Dietary cholesterol enhances torpor in a rodent hibernator
    F Geiser
    Department of Zoology, University of Washington, Seattle 98195, USA
    J Comp Physiol B 167:416-22. 1997
    b>Dietary cholesterol can affect both body lipid composition and steroid hormone concentration...
  68. ncbi Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs
    Peter Verhamme
    Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
    Cardiovasc Res 56:135-44. 2002
    To study the effect of dietary cholesterol withdrawal on size and composition of LDL-hypercholesterolemia-induced coronary plaques in miniature pigs.
  69. pmc Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neurons
    Desheng Wang
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, United States
    Neurosci Lett 479:327-31. 2010
    Previous work has shown high dietary cholesterol can affect learning and memory including rabbit eyeblink conditioning and this effect may be due to increased membrane cholesterol and enhanced hippocampal amyloid beta production...
  70. ncbi Dietary cholesterol and atherosclerosis
    D J McNamara
    Egg Nutrition Center, 1050 17th St NW, Suite 560, Washington, DC 20036, USA
    Biochim Biophys Acta 1529:310-20. 2000
    The perceived relationship between dietary cholesterol, plasma cholesterol and atherosclerosis is based on three lines of evidence: animal feeding studies, epidemiological surveys, and clinical trials...
  71. ncbi The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in rats
    Takako Yokozawa
    Institute of Natural Medicine, University of Toyama, Sugitani, Japan
    Biol Pharm Bull 29:760-5. 2006
    ..The present study suggests that Kangen-karyu could play a protective role against hypercholesterolemia through the regulation of cholesterol levels and inhibition of lipid peroxidation...
  72. ncbi Hepatic HMG-CoA reductase expression and resistance to dietary cholesterol
    Gene C Ness
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    Exp Biol Med (Maywood) 229:412-6. 2004
    ..A (HMG-CoA) reductase determines the relative sensitivity to the serum cholesterol raising action of dietary cholesterol was examined in 9 strains of rat. For further comparison purposes, hamsters were also examined...
  73. ncbi Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico
    Martha Nydia Ballesteros
    Centro de Investigacion y Desarrollo AC, Hermosillo, Sonora, Mexico
    Am J Clin Nutr 80:855-61. 2004
    ..An increased incidence of coronary artery disease (CAD) is prevalent in northern Mexico. Effects of specific dietary components on risk factors for CAD have not been evaluated in children...
  74. pmc Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21
    S B Patel
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9052, USA
    J Clin Invest 102:1041-4. 1998
    The molecular mechanisms regulating the amount of dietary cholesterol retained in the body as well as the body's ability to selectively exclude other dietary sterols are poorly understood...
  75. ncbi Dietary cholesterol reduces lipoprotein lipase activity in the atherosclerosis-susceptible Bio F(1)B hamster
    Martina A McAteer
    Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
    Br J Nutr 89:341-50. 2003
    ....
  76. ncbi Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
    J Nutr 133:1036-42. 2003
    ..of normolipidemic men, classified on the basis of their response to prolonged consumption of additional dietary cholesterol. Using a crossover design, 40 men aged 18-57 y were randomly allocated to an egg (640 mg/d additional ..
  77. ncbi Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbits
    Paolo Zatta
    CNR Center on Metalloproteins, Department of Biology, University of Padova, Italy
    J Alzheimers Dis 4:1-9. 2002
    ..The relevance on the cholesterol metabolism in Alzheimer's disease pathogenesis is also discussed...
  78. ncbi Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammation
    Ya Fan Yeh
    Institute of Public Health, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 11:599-606. 2004
    ..the link between the intake of animal fat and asthma, a murine model was developed to examine the effect of dietary cholesterol on pulmonary allergic inflammation...
  79. pmc Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston MA 02120, USA
    Am J Clin Nutr 87:964-9. 2008
    A reduction in dietary cholesterol is recommended to prevent cardiovascular disease (CVD)...
  80. pmc Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit model
    Michael T Johnstone
    Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, RW 453, Boston, MA 02115, USA
    Circulation 110:2060-5. 2004
    ..This study evaluated the effect of angiotensin receptor blockade on both the development of atherosclerosis and the disruption of plaque in a modified Constantinides animal model...
  81. ncbi Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats
    O A Adaramoye
    Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Clin Exp Pharmacol Physiol 32:40-6. 2005
    ..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
  82. pmc Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol
    Manal Zabalawi
    Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Pathol 163:1201-13. 2003
    ....
  83. ncbi A review of scientific research and recommendations regarding eggs
    Stephen B Kritchevsky
    Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Coll Nutr 23:596S-600S. 2004
    ..This concern is based on three observations: 1. eggs are a rich source of dietary cholesterol; 2. when fed experimentally, dietary cholesterol increases serum cholesterol and; 3...
  84. pmc De Novo induction of atherosclerosis by Chlamydia pneumoniae in a rabbit model
    I W Fong
    Departments of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
    Infect Immun 67:6048-55. 1999
    ..pneumoniae. These data are compatible with de novo induction of atherogenesis by C. pneumoniae in rabbits and suggest that C. pneumoniae may be important in the pathogenesis of atherosclerosis in humans...
  85. ncbi Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged, 1980 (NIPPON DATA80)
    Yasuyuki Nakamura
    Division of Cardiology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan
    Am J Clin Nutr 80:58-63. 2004
    ..Because egg yolk has a high cholesterol concentration, limited egg consumption is often suggested to help prevent ischemic heart disease (IHD)...
  86. ncbi The impact of egg limitations on coronary heart disease risk: do the numbers add up?
    D J McNamara
    Egg Nutrition Center, Washington, DC 20036, USA
    J Am Coll Nutr 19:540S-548S. 2000
    ..The "dietary cholesterol equals blood cholesterol" view is a standard of dietary recommendations, yet few consider whether the ..
  87. ncbi Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge
    Christine M Greene
    Departments of Nutritional Science, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 135:2793-8. 2005
    We previously evaluated the responses to dietary cholesterol in children and young adults...
  88. ncbi Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake
    Kristin L Herron
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    Atherosclerosis 184:113-20. 2006
    ..The presence of individual alleles in this population was associated with differences in plasma lipids and LDL size. However, these relationships were independent of dietary cholesterol.
  89. ncbi Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populations
    Maria Luz Fernandez
    Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
    Curr Opin Clin Nutr Metab Care 9:8-12. 2006
    ..The effects of egg intake on plasma lipids and low-density lipoprotein (LDL) atherogenicity in healthy populations need to be addressed...
  90. ncbi MRI of early- and late-stage arterial remodeling in a low-level cholesterol-fed rabbit model of atherosclerosis
    John A Ronald
    Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
    J Magn Reson Imaging 26:1010-9. 2007
    ..To monitor early- and late-stage arterial remodeling following low-level cholesterol (CH) feeding in rabbits using a standardized MRI protocol...
  91. ncbi Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in ApoE-deficient mice
    Ikuyo Ichi
    Department of Food Science and Nutrition, Nara Women s University, Nara 630 8506, Japan
    Lipids 42:893-900. 2007
    ..In apoE-/- mice, dietary cholesterol significantly increased several ceramides and degradation products of apoB in plasma compared to those fed ..
  92. ncbi Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure
    P H Groot
    Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Welwyn, Hertfordshire, UK
    Arterioscler Thromb Vasc Biol 16:926-33. 1996
    ..On the basis of these findings, we suggest that the APOE*3 Leiden mouse represents a promising model for intervention studies with hypolipidemic and antiatherosclerotic drugs...
  93. ncbi Defatted avocado pulp reduces body weight and total hepatic fat but increases plasma cholesterol in male rats fed diets with cholesterol
    Einat Naveh
    Department of Food Engineering and Biotechnology, Technion, Israel
    J Nutr 132:2015-8. 2002
    ..Regardless of dietary cholesterol, hepatic total fat levels, as evaluated histologically, but not directly, were lower in avocado-fed rats...
  94. pmc Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis
    Robert Kleemann
    Department of Vascular and Metabolic Diseases, TNO Quality of Life, Biosciences, Gaubius Laboratory, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    Genome Biol 8:R200. 2007
    Increased dietary cholesterol intake is associated with atherosclerosis. Atherosclerosis development requires a lipid and an inflammatory component. It is unclear where and how the inflammatory component develops...
  95. ncbi Orlistat inhibits dietary cholesterol absorption
    B Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Obes Res 9:599-604. 2001
    ..Therefore, we evaluated the effect of orlistat treatment on dietary cholesterol absorption as a possible mechanism for the independent effect of orlistat on plasma cholesterol ..
  96. ncbi Does p-glycoprotein play a role in gastrointestinal absorption and cellular transport of dietary cholesterol?
    C Leon
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B C, Canada
    Drug Dev Ind Pharm 32:779-82. 2006
    ..the potential role of p-glycoprotein (Pgp) on the gastrointestinal absorption and cellular transport of dietary cholesterol. This is currently a controversial issue due to the conflicting evidence about the role of this ABC ..
  97. ncbi Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats
    Jen Ying Deng
    Department of Life Science, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
    Am J Physiol Heart Circ Physiol 293:H978-87. 2007
    ..The cardiac metabolic alterations that impair contractile functions may lead to the development of cardiomyopathy...
  98. ncbi Study of garlic extracts and fractions on cholesterol plasma levels and vascular reactivity in cholesterol-fed rats
    K Slowing
    Department of Pharmacology, School of Pharmacy, Complutense University, 28040 Madrid, Spain
    J Nutr 131:994S-9S. 2001
    ..These data suggest that garlic fractions could prevent diet-induced hypercholesterolemia and vascular alterations in the endothelium-dependent relaxation associated with atherosclerosis...
  99. ncbi Dietary cholesterol absorption; more than just bile
    K Lu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    Trends Endocrinol Metab 12:314-20. 2001
    Absorption of dietary cholesterol from the intestine is an important part of cholesterol homeostasis and represents the first step that allows dietary cholesterol to exert its metabolic effects...
  100. ncbi Protective effects of vitamin E and selenium on the renal morphology in rats fed high-cholesterol diets
    S Gonca
    Department of Histology Embryology, Kocaeli University Faculty of Medicine, Derince, Kocaeli, Turkey
    Pathobiology 68:258-63. 2000
    ..In addition, it was concluded that antioxidant therapy may prevent LDL oxidation and generation of free radicals...
  101. ncbi Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosis
    Anna Rull
    Centre de Recerca Biomedica, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, C Sant Joan s n, 43201 Reus, Spain
    Cytokine 48:273-9. 2009
    ..We conclude that dietary cholesterol upregulation of hepatic MCP-1 may help to understand the role of circulating MCP-1 in conditions where ..

Research Grants63

  1. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The plasma levels of LDL are strongly influenced by dietary cholesterol and body's ability to store and metabolize ingested cholesterol...
  2. Dietary Cholesterol and Defects in Cholesterol Synthesis
    ROBERT DAVID STEINER; Fiscal Year: 2013
    ..Together, the in vivo and in vitro studies proposed should shed light on the pathogenesis of SLOS, and offer insights into treatment that to date have eluded investigators. ..
  3. Regulation of Metabolism by Dietary Sterols
    SHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013
    ..The pathway how our bodies regulate dietary cholesterol was elucidated by our recent work on a genetic disorder, sitosterolemia, which is associated with premature ..
  4. The role of caveolin 1 in intestinal lipid processing and transport
    JESSICA OTIS; Fiscal Year: 2013
    ..efflux to high-density lipoproteins (HDL);mice lacking CAV1 have altered plasma lipids despite normal dietary cholesterol absorption. Thus, intestinal caveolae may play a role in lipid metabolism and cardiovascular disease...
  5. Inflammation, Atherosclerosis and ApoA-I
    Mary G Sorci-Thomas; Fiscal Year: 2013
    ..Regardless of the level of dietary cholesterol, DKO mice consistently showed lower plasma cholesterol than SKO mice, yet greater aortic cholesterol ..
  6. Effect of Nutritional Factors on Macrophage Accumulation in Adipose Tissue
    Alan Chait; Fiscal Year: 2012
    ..These nutritional factors include glucose excess, certain saturated fatty acids and dietary cholesterol (or oxysterols that result from cholesterol oxidation in foods)...
  7. Intralumental Effect on Cholesterol Absorption/Synthesis
    James Heubi; Fiscal Year: 2009
    ..the intraluminal solubilization and distribution within micelles and vesicles of biliary compared to dietary cholesterol in humans and assess the impact of ezetimibe treatment on absorption of endogenous or exogenous cholesterol ..
  8. Cholesterol and copper affect learning and memory
    Bernard G Schreurs; Fiscal Year: 2013
    ..This work is important because of the impact it will have on understanding the role of dietary cholesterol and beta amyloid deposits in learning and memory and on our understanding of the pathogenesis of failures ..
  9. Co-localizing Quantitative Trait Loci for Bone Mineral Density and HDL in Mice
    CHERYL LYNNE ACKERT-BICKNELL; Fiscal Year: 2013
    ..Furthermore, both of these BMD QTL interact with dietary cholesterol intake...
  10. Cholesterol_fat_absorption
    Ephraim Sehayek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The absorption of dietary cholesterol and fat from the intestine are important modifiers of plasma cholesterol level, adiposity, and risk for atherosclerotic cardiovascular diseases...
  11. Fetal Lead Exposure, Genes, and Neurodevelopment
    Howard Hu; Fiscal Year: 2010
    ..impact on behavior and that assess the potential for measures of maternal circulating cholesterol, maternal dietary cholesterol, and infant 24S-hydroxy cholesterol (a novel plasma biomarker of CNS cholesterol) to modify the lead-gene ..
  12. Atherogenic Induction of Neuroinflammation
    Narayan R Bhat; Fiscal Year: 2010
    ..The specific objectives are to determine if the kinase depletion and pharmacological intervention reduce dietary cholesterol-induced neuroinflammation and increased amyloid deposition in the APPTg mice with the outcome of an ..
  13. Sterol and Coenzyme Q metabolism in C. elegans
    Fernando Gomez; Fiscal Year: 2010
    ..Nematodes are unable to synthesize sterols de novo, and rely on dietary cholesterol for their sterol needs...
  14. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..four diets will be fed to subjects consuming a cholesterol-free diet and in the presence of 600 mg/day of dietary cholesterol. The metabolic effects of long chain polyunsaturated fatty acids derived from fish oil will be examined in ..
  15. REVERSE CHOLESTEROL TRANSPORT IN HUMANS
    Richard E Ostlund; Fiscal Year: 2013
    ..a different oral tracer, to partition fecal cholesterol into excreted endogenous cholesterol, unabsorbed dietary cholesterol and newly-synthesized cholesterol derived from the liver and intestine...
  16. DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINS
    PHYLLIS MCPHERSON; Fiscal Year: 1990
    Controlled dietary studies will be carried out in 40 Caucasian males to determine the effects of dietary cholesterol on the apolipoprotein and lipid composition of plasma lipoprotein subfractions and the plasma phosphatidylcholine/free ..
  17. PREMATURE WEANING AND ADULT CHOLESTEROL HOMEOSTASIS
    DONALD MC NAMARA; Fiscal Year: 1993
    ..by premature weaning on the homeostatic responses to changes in dietary fat (corn oil versus lard) and in dietary cholesterol. Studies will determine the effects on the regulation of hepatic and extrahepatic sterol synthesis (hepatic ..
  18. STEROL METABOLISM & DIETARY CHOLESTEROL IN SLO SYNDROME
    WILLIAM CONNOR; Fiscal Year: 2002
    ..The principal investigator (PI) has proposed to feed dietary cholesterol from three different sources, egg yolk, crystalline cholesterol and butterfat to SLOS patients...
  19. EXPRESSION OF APOLIPOPROTEIN GENES IN TRANSGENIC RABBITS
    John Taylor; Fiscal Year: 2001
    ..The rabbit is used as the experimental model because of its exaggerated response to dietary cholesterol, its sensitivity to apoE levels, and its distinct phenotypes upon transgene expression...
  20. LIPID AND LIPOPROTEIN METABOLISM IN INSECTS
    Michael Wells; Fiscal Year: 2005
    ..b>Dietary cholesterol, or sterols that can be converted to cholesterol, are critical for insects because they cannot make sterols ..
  21. PROSPECTIVE STUDY OF DIET AND CARDIOVASCULAR DISEASE
    Jiang He; Fiscal Year: 1999
    Cardiovascular disease is the leading cause of death among residents of the United States. The effect of dietary cholesterol and fat on risk of coronary heart disease (CHD) and stroke has been examined extensively in epidemiologic ..
  22. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    Pancreatic cholesterol esterase (CE) has a dual function in the absorption of dietary cholesterol. First, CE catalyzes the hydrolysis of cholesterol esters to liberate cholesterol for absorption; second, CE transports cholesterol from ..
  23. EPIDEMIOLOGY OF PLASMA FATTY ACIDS AND ATHEROSCLEROSIS
    John Eckfeldt; Fiscal Year: 1991
    ..S. and all other industrialized nations. High dietary cholesterol is now well recognized as a major atherosclerotic risk factor...
  24. SYNTHESIS OF HELMINTHOSPOROL ANALOGS AS ACAT INHIBITORS
    EDUARD CASILLAS; Fiscal Year: 2004
    ..Therefore, ACAT may play an important role in the absorption of dietary cholesterol. An efficient ACAT inhibitor has the potential to function therapeutically as an anti-atherosclerotic agent ..
  25. MECHANISM OF ESTROGEN EFFECTS ON BILIARY CHOLESTEROL
    FRED KERN; Fiscal Year: 1991
    ..Plasma apoprotein A-I and B will be measured by ELISA in both studies. An additional hypothesis that dietary cholesterol contributes to the pathogenesis of cholesterol gallstone in some subjects will be tested by measuring the ..
  26. CELL MUTANTS DEFECTIVE IN CHOLESTEROL ESTER FORAMTION
    Ta Yuan Chang; Fiscal Year: 2003
    ..to play significant roles in lipoprotein assembly and secretion, in steroid hormone production, and in dietary cholesterol absorption...
  27. CHOLESTEROL-RICH DIET AND PLASMA LIPID TRANSPORT
    Wolfgang Patsch; Fiscal Year: 1991
    ..may be challenged because of heterogeneity in the genetic makeup influencing an individual's response to dietary cholesterol. The goals of this proposal are i) to define the principal mechanism(s) which determine the reaction of the ..
  28. HUMAN CHOLESTEROL METABOLISM--NEW METHODS ACUTE STUDIES
    Dale Schoeller; Fiscal Year: 1993
    ..One factor known to increase plasma cholesterol level is dietary cholesterol intake, however, not all individuals increase plasma cholesterol levels in response to cholesterol intake...
  29. CHOLESTEROL METABOLISM IN ATHEROSCLEROSIS RESISTANCE
    MERRILL OVERTURF; Fiscal Year: 1990
    The New Zealand rabbit is a species that is characteristically sensitive to dietary cholesterol and rapidly develops hypercholesterolemia and atherosclerosis...
  30. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..rafts in apical sterol transport;and the regulation of ABC transporters and NPC1L1 in hamster intestine by dietary cholesterol, plant sterols, or fat...
  31. EFFECTS OF LIFESTYLE CHANGES ON CORONARY HEART DISEASE
    Dean Ornish; Fiscal Year: 1992
    ..To date, 17 patients have completed testing at baseline and after one year. In the experimental group, dietary cholesterol had decreased from 215.0 for 2.6 mg/day and total dietary fat has decreased from 70.0 to 15...
  32. CATABOLISM AND EXCRETION OF CHOLESTEROL AND BILE ACIDS
    David Loose; Fiscal Year: 2002
    ..The goal of this proposal is to determine how two key pathways of bile acid biosynthesis are regulated by dietary cholesterol and to determine the mechanisms regulating the apical Na+ -dependent bile-acid transport protein (ASBP) in ..
  33. Genes, Hormones & Environment in an Ovarian Cancer Model
    Daniel Cramer; Fiscal Year: 2007
    ..Steroid production is also enhanced by caffeine use, a predicted risk factor interacting with dietary cholesterol or caffeine metabolism...
  34. Behavioral factors and dietary change in WHTFSMP
    Alok Bhargava; Fiscal Year: 2003
    ..Behavioral factors, anthropometric indicators, energy derived from saturated and polyunsaturated fats, and dietary cholesterol will be explanatory variables in models for plasma LDL cholesterol...
  35. REGULATION OF AMYLOID BETA PROTEIN BY APOE & CHOLESTEROL
    Bruce Yankner; Fiscal Year: 2004
    ..elucidate the role of apoE in the metabolism of AB and amyloid precursor protein (APP) and its control by dietary cholesterol. The studies in this proposal are based on the working hypothesis that the absolute level of apoE is a ..
  36. EFFECTS OF DIETARY CHOLESTEROL ON LIPOPROTEIN METABOLISM
    RAMPRATAP KUSHWAHA; Fiscal Year: 1991
    ..the metabolic and molecular mechanisms by which individuals in a population respond differently to dietary cholesterol and how dietary fat modulates this response...
  37. EFFECTS OF LIFESTYLE CHANGES ON CORONARY HEART DISEASE
    K Gould; Fiscal Year: 1992
    ..In the experimental group, dietary cholesterol has decreased from 215.0 to 2.6 mg/day and total dietary fat has decreased from 70.0 to 15...
  38. GENETIC AND BIOMEDICAL STUDIES OF SITOSTEROLEMIA
    Shailendra Patel; Fiscal Year: 2003
    ..One of these risk factors is cholesterol. Understanding the factors that normally regulate net dietary cholesterol intake may allow us to reduce the impact of this risk factor...
  39. CHOLESTEROL METABOLISM--BIOLOGIC ROLE OF 27 HYDROXYLATIO
    Norman Javitt; Fiscal Year: 2000
    ..rabbits recent data implying that the cholesterol 27-hydroxylase pathway is specific for the metabolism of dietary cholesterol to bile acids...
  40. DETECTION OF LDL-RECEPTORS IN COLON AND COLON TUMORS
    SELWYN BROITMAN; Fiscal Year: 1991
    ..b>Dietary cholesterol contributes to risk for colon cancer epidemiologically and experimentally, but little is known of ..
  41. DIET EFFECTS--LIPOPROTEIN METABOLISM & PLATELET FUNCTION
    Henry Ginsberg; Fiscal Year: 1990
    ..effects of a diet containing 30% fat with those of a 20% fat diet; 3) compare the effects of 3 levels of dietary cholesterol (500 mg, 250 mg, and 100 mg per day); and 4) compare the effects of omega-3 and omega-6 fatty acid...
  42. MOLECULAR MECHANISMS OF CHOLESTEROL ABSORPTION
    David Hui; Fiscal Year: 2003
    ..Because high dietary cholesterol intake is a major risk factor for heart disease, diabetes, obesity, and certain forms of cancer, results of ..
  43. DIETARY CHOLESTEROL EFFECTS ON LIPOPROTEIN METABOLISM
    Lawrence Rudel; Fiscal Year: 1992
    In some individuals, an elevation in dietary cholesterol intake causes hypercholesterolemia and an increased risk of premature coronary heart disease (CHD)...
  44. SPECIALIZED CENTER OF RESEARCH IN ARTERIOSCLEROSIS
    RICHARD ST CLAIR; Fiscal Year: 1991
    ..on genetic and biochemical mechanisms in determining hypo or hyperresponsiveness of nonhuman primates to dietary cholesterol, comparative studies of pleomorphic features of fatty streaks, studies on endothelial permeability, lesion ..
  45. Gene-diet interactions and dietary cholesterol response
    Jan Breslow; Fiscal Year: 2005
    b>Dietary cholesterol and saturated fatty acids raise LDL cholesterol levels and atherosclerotic cardiovascular disease risk...
  46. Cholesterol and Prostate Cancer Progression
    Keith Solomon; Fiscal Year: 2007
    ..This application responds to the RFA by directly evaluating the effect of dietary cholesterol on prostate tumor progression and the ability of membrane cholesterol to regulate the ErbB/PI3K/Akt anti-..
  47. DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINS
    Christopher Fielding; Fiscal Year: 1991
    Increased dietary cholesterol and saturated fat have been shown to be related to increased levels of plasma cholesterol (particularly in low density lipoproteins) and vascular disease...
  48. LIPID VARIABILITY--INFLUENCE OF STRESS
    James Raczynski; Fiscal Year: 1992
    ..affect lipids: dietary intake (including alcohol, caffeine, total calories, total fat, saturated fat, and dietary cholesterol), smoking, and physical activity, and oral contraceptive use, pregnancy status and menstrual stage among ..
  49. RURAL LIPID RESOURCE CENTER--A PHYSICIAN-ASSIST MODEL
    Roberta Reed; Fiscal Year: 1993
    ..on appropriate drug) and outcome (change in % of total calories as fat and saturated fat, milligrams of dietary cholesterol, mg/di reduction in LDL cholesterol levels, and cost of intervention)...
  50. Feedback and Hormonal Regulation of Hepatic HMG-CoA Reductase
    GENE CHARLES NESS; Fiscal Year: 2010
    ..studies demonstrating that intrinsic resistance to the serum and tissue cholesterol raising action of dietary cholesterol is proportional to the level of expression of hepatic HMGR make knowledge of the physiological mechanisms ..
  51. Conditioning-specific reflex modification
    BERNARD SCHREURS; Fiscal Year: 2004
    ..abstract_text> ..
  52. Mineralization studies related to atherosclerosis
    HOWARD HSU; Fiscal Year: 2004
    ..abstract_text> ..
  53. Hyperglycemia, Aldose Reducatse & Murine Atherosclerosis
    Ira Goldberg; Fiscal Year: 2005
    ..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
  54. TREATMENT PREFERENCE AND VEGETARIAN DIET IN WEIGHT LOSS
    Lora Burke; Fiscal Year: 2005
    ..Additionally, the study will provide information on the role of treatment preference, its effect on behavioral and clinical outcomes, and participants' characteristics by treatment preference. ..
  55. Chromium Effects in Imparied Glucose Tolerance
    David Katz; Fiscal Year: 2006
    ..By contributing to knowledge related to potential diabetes prevention strategies, this study addresses one of the more pressing public health issues in the US today. ..
  56. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ....
  57. Improving Self-Monitoring in Weight Loss with Technology
    Lora E Burke; Fiscal Year: 2010
    ..Subjects will complete assessments at baseline, 6, 12, 18, and 24 months. This innovative study will provide information on the efficacy of combining technological advances with proven behavioral strategies. ..
  58. IVMT for Fibromyalgia Syndrome: A Pilot Study
    David Katz; Fiscal Year: 2004
    ..The identification of an effective, safe, inexpensive therapy for fibromyalgia would represent a great advance, and a major contribution to the public health. ..
  59. ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINS
    Ira Goldberg; Fiscal Year: 2003
    ..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
  60. Long-term changes in weight and adipokines and the associations with genetic vari
    Lora E Burke; Fiscal Year: 2010
    ..The proposed study and mentoring strategies will be placed in the context of an area of NINR emphasis - promoting health and preventing disease as it addresses a highly prevalent chronic disorder - overweight and obesity. ..