Genomes and Genes
Summary: Cholesterol present in food, especially in animal products.
Publications224 found, 100 shown here
- Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterolE Sarkkinen
Department of Clinical Nutrition, University of Kuopio, Finland
Am J Clin Nutr 68:1215-22. 1998..The magnitude of the influence of the apolipoprotein (apo) E genotype on the lipid response to different cholesterol-lowering diet modifications has been controversial...
- Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitisKristiaan Wouters
Department of Molecular Genetics, Physiology and Electron Microscopy Unit, Nutrition and Toxicology Research and Cardiovascular Research, Institutes of Maastricht University, Maastricht, The Netherlands
Hepatology 48:474-86. 2008..The role of steatosis and dietary cholesterol in the etiology of diet-induced NASH was investigated using hyperlipidemic mouse models fed a Western diet...
- Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysisR M Weggemans
Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, Netherlands
Am J Clin Nutr 73:885-91. 2001..OBJECTIVE: The objective was to review the effect of dietary cholesterol on the ratio of total to HDL cholesterol...
- Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver diseaseMaria Vinaixa
Metabolomics Platform, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, IISPV, Universitat Rovira i Virgili, Avda Països Catalans 26, 43007 Tarragona, Spain
J Proteome Res 9:2527-38. 2010..b>Dietary cholesterol increased the hepatic concentrations of cholesterol, triglycerides, and oleic acid but also decreased the [..
- Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilizationHeather M Alger
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
J Biol Chem 285:14267-74. 2010..lipid (TG and cholesteryl ester) accumulation, with the greatest differences occurring in situations where dietary cholesterol was elevated...
- Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterolH Gullberg
Laboratory of Developmental Biology, Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
Mol Endocrinol 14:1739-49. 2000..contribution of thyroid hormone receptors (TR) alpha1 and beta in this regulation, the responses to 2% dietary cholesterol and T3 were studied in TRalpha1 and TRbeta knockout mice under hypo- and hyperthyroid conditions...
- Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient miceSavitha Subramanian
Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195 6426, USA
Arterioscler Thromb Vasc Biol 28:685-91. 2008Chronic systemic inflammation accompanies obesity and predicts development of cardiovascular disease. Dietary cholesterol has been shown to increase inflammation and atherosclerosis in LDL receptor-deficient (LDLR(-/-)) mice...
- Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient miceMonica Tous
Centre de Recerca Biomedica, Institut de Recerca en Ciències de la Salut IRCIS, Hospital Universitari de Sant Joan, Calle Sant Joan s n, 43201 Reus, Spain
Biochem Biophys Res Commun 340:1078-84. 2006..Both tissues respond in a similar way when dietary cholesterol is provided for a few weeks but differently if the conditions persist for a protracted period of time...
- Effect of dietary cholesterol and high fat on ceramide concentration in rat tissuesIkuyo Ichi
Department of Food Science and Nutrition, Nara Women s University, Nara, Japan
Nutrition 23:570-4. 2007..In addition, we found a relation among lipid markers of atherosclerosis such as cholesterol, triacylglycerol, and ceramide concentrations...
- Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanismHyoun ju Kim
Departments of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA
J Lipid Res 43:1750-7. 2002..This study demonstrates that cholesterol overrides the PUFA-mediated repression of the SCD1 gene and regulates SCD1 gene expression through a mechanism independent of SREBP-1 maturation...
- Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient miceS Alberti
Department of Biosciences at Novum, Karolinska Institutet, Huddinge, Sweden
J Clin Invest 107:565-73. 2001..mouse lines with targeted disruptions of each of these LXR receptors and have compared their responses to dietary cholesterol. Serum and hepatic cholesterol levels and lipoprotein profiles of cholesterol-fed animals revealed no ..
- Increase in serum amyloid a evoked by dietary cholesterol is associated with increased atherosclerosis in miceKatherine E Lewis
Department of Medicine, University of Washington, Seattle, Wash 98195 6426, USA
Circulation 110:540-5. 2004..Therefore, we hypothesized that diet-induced increases in SAA would increase atherosclerosis independent of their effect on plasma cholesterol levels...
- Hypercholesterolemia promotes inflammation and microvascular dysfunction: role of nitric oxide and superoxideKaren Y Stokes
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, LA 71130 3932, USA
Free Radic Biol Med 33:1026-36. 2002..Agents that act to maintain the normal balance between NO and reactive oxygen species (ROS) in vascular endothelial cells may prove particularly useful in this regard...
- Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: a randomized clinical trialJanette Khoury
Department of Obstetrics and Gynecology, National University Hospital, Oslo, Norway
Am J Obstet Gynecol 193:1292-301. 2005..We assessed the effect of a cholesterol-lowering diet on maternal, cord, and neonatal plasma lipids and pregnancy outcome...
- Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transportersK E Berge
Department of Molecular Genetics and McDermott Center for Human Growth and Development and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
Science 290:1771-5. 2000..These data suggest that ABCG5 and ABCG8 normally cooperate to limit intestinal absorption and to promote biliary excretion of sterols, and that mutated forms of these transporters predispose to sterol accumulation and atherosclerosis...
- Pre-menopausal women, classified as hypo- or hyperresponders, do not alter their LDL/HDL ratio following a high dietary cholesterol challengeKristin L Herron
Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
J Am Coll Nutr 21:250-8. 2002..However, the impact of excess dietary cholesterol intake on plasma cholesterol levels cannot be accurately predicted; therefore, its role in disease ..
- Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout miceNadya Khan-Merchant
Nutrition and Health Sciences Program, Division of Biological and Biomedical Sciences, and Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA 30322, USA
J Nutr 132:3256-62. 2002..05). Our results suggest that, in mice fed cholesterol, oxidized fatty acids may be atherogenic, both in terms of increased oxidative stress (as seen in study 1) and by increasing the atherogenicity of the plasma cholesterol profile...
- APP and PS-1 mutations induce brain oxidative stress independent of dietary cholesterol: implications for Alzheimer's diseaseHafiz Mohmmad Abdul
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
Neurosci Lett 368:148-50. 2004..the brain homogenates from knock-in mice expressing mutant human PS-1 and APP in relation to the intake of dietary cholesterol. The APP and PS-1 mice displayed increased oxidative stress as measured by protein oxidation and lipid ..
- Egg consumption and risk of type 2 diabetes in men and womenLuc Djousse
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 32:295-300. 2009Whereas limited and inconsistent findings have been reported on the relation between dietary cholesterol or egg consumption and fasting glucose, no previous study has examined the association between egg consumption and type 2 diabetes...
- ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickensJacob D Mulligan
Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Biol Chem 278:13356-66. 2003..0- and 4.4-fold, respectively), whereas biliary lipid concentrations were unaltered by the WHAM mutation. In summary, ABCA1 regulates the efflux of cholesterol from the basolateral but not apical membrane in the intestine and the liver...
- Dietary cholesterol plays a role in CD36-mediated atherogenesis in LDLR-knockout miceDavid J Kennedy
Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Arterioscler Thromb Vasc Biol 29:1481-7. 2009..We observed no difference in aortic lesion area between Western diet (WD)-fed LDLR(o) and LDLR(o)/CD36(o) mice. The objective was to understand the mechanism of CD36-dependent atherogenesis...
- Dietary fat and incidence of type 2 diabetes in older Iowa womenK A Meyer
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes Care 24:1528-35. 2001..CONCLUSIONS: These data support an inverse relation between incident type 2 diabetes and vegetable fat and substituting polyunsaturated fatty acids for saturated fatty acids and cholesterol...
- Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27 Kip1 -independent pathwayClaudia Castro
Laboratorio de Biología Vascular, Departamento de Patología y Terapia Molecular y Celular, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas, C Jaime Roig 11, 46010, Valencia, Spain
Atherosclerosis 172:31-8. 2004..Our results suggest that rapamycin-dependent atheroprotection occurs through a p27(Kip1)-independent pathway that involves reduced expression of positive cell cycle regulators and MCP-1 within the arterial wall...
- The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggsKristin L Herron
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
J Nutr 136:1161-5. 2006The ATP binding cassette G5 (ABCG5) polymorphisms have been postulated to play a role in the response to dietary cholesterol. The objective of this study was to examine the contribution of the ABCG5 polymorphism on the plasma response to ..
- Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in ratsMakoto Asahina
Laboratory of Nutrition Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
J Lipid Res 50:41-6. 2009..identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary ..
- Neonatal dietary cholesterol and alleles of cholesterol 7-alpha hydroxylase affect piglet cerebrum weight, cholesterol concentration, and behaviorWilson G Pond
USDA Agricultural Research Service, Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
J Nutr 138:282-6. 2008..designed to test the effect of polymorphism in the cholesterol 7-alpha hydroxylase (CYP7) gene locus and dietary cholesterol (C) on cerebrum C in neonatal pigs fed sow's milk formulas...
- Lipoprotein metabolism in the fat Zucker rat: reduced basal expression but normal regulation of hepatic low density lipoprotein receptorsW Liao
Center for Nutrition and Toxicology, Novum, Department of Medicine, Karolinska Institute at Huddinge University Hospital, Sweden
Endocrinology 138:3276-82. 1997..Challenge with 2% dietary cholesterol for 8 days suppressed hepatic LDL receptor expression in lean animals to similar levels as seen in fat ones,..
- The lipoprotein/lipid profile is modulated by a gene-diet interaction effect between polymorphisms in the liver X receptor-alpha and dietary cholesterol intake in French-CanadiansJulie Robitaille
Lipid Research Center, CHUQ CHUL, Ste Foy, Quebec, Canada
Br J Nutr 97:11-8. 2007..0 mmol/l) and LDL-cholesterol (>3.5 mmol/l) concentrations. dietary cholesterol was obtained from a food-frequency questionnaire. The LXRalpha c.-115G>A, c.-840C>A and c...
- Primates highly responsive to dietary cholesterol up-regulate hepatic ACAT2, and less responsive primates do notLawrence L Rudel
Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Biol Chem 277:31401-6. 2002..the principal ACAT enzyme within primate hepatocytes, as a regulator of the hypercholesterolemia induced by dietary cholesterol was studied...
- Lovastatin alters biliary lipid composition and dissolves gallstones: a long-term study in prairie dogsMohammad Z Abedin
Department of Surgery, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA
Dig Dis Sci 47:2192-210. 2002..These data suggest that lovastatin therapy alone may promote gallstone dissolution in humans...
- Dietary cholesterol and egg yolks: not for patients at risk of vascular diseaseJ David Spence
Stroke Prevention and Atheroschlerosis Research Centre, Robarts Research Institute, London, Ontario
Can J Cardiol 26:e336-9. 2010..It is increasingly believed that consumption of dietary cholesterol and egg yolks is harmless...
- Effects of dietary cholesterol and fat on serum non-cholesterol sterols according to different apolipoprotein E subgroups among healthy menMarkku J Nissinen
Division of Gastroenterology, Department of Medicine, University of Helsinki, C422, POB 700, Helsinki FI 00029, Finland
Br J Nutr 100:373-9. 2008..Surrogate sterol markers of cholesterol metabolism reflected absolute ones (especially in the apo E4 group) and apo E phenotypes despite variable amounts of dietary cholesterol and fat.
- Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observationsD L Sparks
Sun Health Research Institute, Sun City, Arizona, USA
Ann N Y Acad Sci 903:335-44. 2000..b>Dietary cholesterol induced a twofold increase in beta-amyloid concentration in rabbit hippocampal cortex, which may be related ..
- Response of plasma lipids to dietary cholesterol and wine polyphenols in rats fed polyunsaturated fat dietsL Fremont
Laboratoire de Nutrition et Securite Alimentaire, INRA CRJ, Jouy en Josas, France
Lipids 35:991-9. 2000..0001). However, the cholesterol content of liver microsomes was not affected. Dietary cholesterol altered the distribution of fatty acids mainly by reducing the ratio of arachidonic acid to linoleic acid (..
- Dietary cholesterol suppresses the ability of olive oil to delay the development of atherosclerotic lesions in apolipoprotein E knockout miceSergio Acin
Departamento de Bioquimica y Biologia Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain
Atherosclerosis 182:17-28. 2005..They also suggest that the mere inclusion of olive oil in Western diets is insufficient and the adoption of Mediterranean diet would be more effective in retarding the development of atherosclerotic lesions...
- Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcificationHoward H T Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160 7410, USA
Atherosclerosis 161:85-94. 2002....
- In vitro effect of cholesterol on calcifying activity of vesicles isolated from rabbit aortasHoward H T Hsu
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 7410, USA
Biochim Biophys Acta 1638:235-40. 2003..Altogether, these observations suggest that cholesterol and especially its oxidized forms may induce aortic calcification by directly enhancing the vesicle's ability to calcify...
- Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitisMonica Tous
Centre de Recerca Biomedica, Institut de Recerca en Ciències de la Salut, Hospital Universitari de Sant Joan, 43201 Reus, Catalunya, Spain
Mol Cell Biochem 268:53-8. 2005..We conclude that apolipoprotein E-knockout mice may be a useful model for investigating the mechanisms of diet-induced steatohepatitis...
- Liver copper content of rats hypo- or hyperresponsive to dietary cholesterolIngeborg de Wolf
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands
J Trace Elem Med Biol 17:177-82. 2003..One strain was dietary cholesterol resistant (SHR/OlaIpcv), whereas the other strain was susceptible to dietary cholesterol (BN-Lx/Cub)...
- Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeysA K Bhattacharyya
Department of Pathology, Louisiana State University Medical Center, New Orleans 70112
Atherosclerosis 67:33-9. 1987..The results also suggest that there might be a lower sensitivity in the feedback inhibition mechanism of cholesterol biosynthesis in the high-responding than in the low-responding rhesus monkeys...
- Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic miceLuis B Agellon
Department of Biochemistry and Canadian Institutes of Health Research Group in Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
J Biol Chem 277:20131-4. 2002b>Dietary cholesterol has been shown to have a stimulatory effect on the murine cholesterol 7alpha-hydroxylase gene (Cyp7a1), but its effect on human cholesterol 7alpha-hydroxylase gene (CYP7A1) expression in vivo is not known...
- Dietary cholesterol modulates delta6 and delta9 desaturase mRNAs and enzymatic activity in rats fed a low-eFA dietRodolfo R Brenner
Instituto de Investigaciones Bioquimicas de La Plata, CONICET UNLP, Facultad de Ciencias Medicas, Argentina
Lipids 37:375-83. 2002..Taken together, these results indicate that through its modulating effect on the desaturases, dietary cholesterol may lead an animal or human fed low-EFA diet to a true deficiency by the decreased synthesis of the highly ..
- Cholesterol and copper in the liver of rabbit inbred strains with differences in dietary cholesterol responseIngeborg D de Wolf
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Graduate School of Animal Health, Utrecht University, Utrecht, The Netherlands
J Nutr Biochem 14:459-65. 2003..One strain was not reactive to dietary cholesterol (IIIVO/JU), whereas the other strain was reactive to dietary cholesterol (AX/JU)...
- Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesisD F Jelinek
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
J Biol Chem 265:8190-7. 1990..b>Dietary cholesterol led to an increase in 7 alpha-hydroxylase mRNA levels...
- Locus controlling LDL cholesterol response to dietary cholesterol is on baboon homologue of human chromosome 6Candace M Kammerer
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Arterioscler Thromb Vasc Biol 22:1720-5. 2002..a potential quantitative trait locus (QTL) in baboons that influenced low density lipoprotein cholesterol response to dietary cholesterol. We performed linkage analyses to locate this QTL by using data on the baboon genetic linkage map.
- Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activatedGuorong Xu
Gastrointestinal Lab 15A Veterans Affairs Medical Center, 385 Tremont Ave, East Orange, NJ 07018 1095, USA
Am J Physiol Gastrointest Liver Physiol 286:G730-5. 2004..To clarify the mechanism responsible for the upregulation of CYP7A1 in cholesterol-fed rats, the effects of dietary cholesterol (Ch) and cholic acid (CA) on the activation of the nuclear receptors, liver X-receptor (LXR-alpha) and ..
- Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult menGisella Mutungi
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, 06269 USA
Lipids Health Dis 6:34. 2007..Subjects were randomly assigned to either EGG (640 mg/d additional dietary cholesterol) or SUB groups [equivalent amount of egg substitute (0 dietary cholesterol contributions) per day] for 12 ..
- High dietary cholesterol facilitates classical conditioning of the rabbit's nictitating membrane responseBernard G Schreurs
Department of Physiology and Pharmacology, West Virginia University, Blanchette Rockefeller Neurosciences Institute, Morgantown, WV, USA
Nutr Neurosci 10:31-43. 2007Studies have shown that modifying dietary cholesterol may improve learning and that serum cholesterol levels can be positively correlated with cognitive performance. Rabbits fed a 0, 0.5, 1 or 2% cholesterol diet for eight weeks and 0...
- Behavioral effects of dietary cholesterol in rats tested in experimental models of mild stress and cognition tasksVincenzo Micale
Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy
Eur Neuropsychopharmacol 18:462-71. 2008..However, evidence for an influence of dietary cholesterol on behavioral models is poor...
- Classical conditioning of the rabbit's nictitating membrane response is a function of the duration of dietary cholesterolBernard G Schreurs
Department of Physiology and Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University, Morgantown, WV, USA
Nutr Neurosci 10:159-68. 2007Modifying dietary cholesterol may improve learning and memory but very high cholesterol can cause pathophysiology and death. Rabbits fed 2% cholesterol for 8, 10 or 12 weeks with 0...
- Dietary cholesterol impairs memory and memory increases brain cholesterol and sulfatide levelsDeya S Darwish
Department of Neurobiology and Anatomy, Blanchette Rockefeller Neurosciences Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Behav Neurosci 124:115-23. 2010..We show that dietary cholesterol had an adverse effect on memory recall...
- Docosahexaenoic acid but not eicosapentaenoic acid withstands dietary cholesterol-induced decreases in platelet membrane fluidityMichio Hashimoto
Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane 693 8501, Japan
Mol Cell Biochem 293:1-8. 2006..These results suggest that DHA is a more potent membrane-fluidizer than EPA in withstanding cholesterol-induced decreases in platelet membrane fluidity and a stronger ameliorative modulator of platelet hyperaggregation...
- Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolaseB R Krause
Department of Vascular and Cardiac Diseases, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
Lipids 33:489-98. 1998..that WAY-121,898 inhibits more than just the intestinal (lumenal) pCEH, and that the role of this enzyme in cholesterol metabolism may be different within and across species, the former depending upon the dietary cholesterol load.
- Nutritional investigation of non-obese patients with non-alcoholic fatty liver disease: the significance of dietary cholesterolKenichiro Yasutake
Dietetic Laboratory, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan
Scand J Gastroenterol 44:471-7. 2009..The purpose of this study was to identify potential nutritive factors that affect NAFLD and its related nutritional problems...
- Addition of dietary fat to cholesterol in the diets of LDL receptor knockout mice: effects on plasma insulin, lipoproteins, and atherosclerosisLan Wu
Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY, USA
J Lipid Res 47:2215-22. 2006..Our data suggest that when lipoprotein profiles are similar, addition of fat to a cholesterol-rich diet does not increase atherosclerotic lesion formation in Ldlr(-/-) mice...
- Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorptionM H Lee
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
Nat Genet 27:79-83. 2001The molecular mechanisms regulating the amount of dietary cholesterol retained in the body, as well as the body's ability to exclude selectively other dietary sterols, are poorly understood...
- Effects of dietary cholesterol and simvastatin on cholesterol synthesis in Smith-Lemli-Opitz syndromeYen Ming Chan
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Manitoba, Canada
Pediatr Res 65:681-5. 2009..However, the effect of dietary cholesterol and simvastatin on cholesterol synthesis in SLOS has not been reported...
- Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted miceP N Howles
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0529, USA
J Biol Chem 271:7196-202. 1996..These results indicate that cholesterol esterase is responsible for mediating intestinal absorption of cholesteryl esters but does not play a primary role in free cholesterol absorption...
- Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosisHeather Basciano
Department of Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada
Am J Physiol Endocrinol Metab 297:E462-73. 2009Although the atherogenic role of dietary cholesterol has been well established, its diabetogenic potential and associated metabolic disturbances have not been reported...
- Cholesterol feeding increases C-reactive protein and serum amyloid A levels in lean insulin-sensitive subjectsLisa R Tannock
Department of Medicine, University of Washington, 1959 NE Pacific St, Seattle, WA 98195 6426, USA
Circulation 111:3058-62. 2005Inflammatory markers associated with elevated cardiovascular risk are increased by cholesterol feeding in animal models. However, whether dietary cholesterol increases inflammatory marker levels in humans is not known.
- Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted dietGisella Mutungi
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
J Nutr 138:272-6. 2008..Increasing intake of dietary cholesterol from eggs in the context of a low-fat diet maintains the LDL cholesterol (LDL-C)/HDL-C for both hyper- and ..
- Increased dietary cholesterol enhances cold tolerance in Drosophila melanogasterScott M Shreve
Department of Zoology, Miami University, Oxford, Ohio 45056, USA
Cryo Letters 28:33-7. 2007..7+/-4.4 percent) compared to flies on a control diet (20.0+/-2.9 percent). These results suggest a mechanistic link between protection from chilling or cold shock injury and modifications to the cellular membrane...
- Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: effects of dietary cholesterol and phytosterolsM H Moghadasian
Department of Pathology and Laboratory Medicine, St Paul s Hospital and University of British Columbia, Vancouver, Canada
Lab Invest 79:355-64. 1999....
- The effect of ingestion of egg on the serum lipid profile of healthy young IndiansGayatri Chakrabarty
Department of Physiology, All India Institute of Medical Sciences, New Delhi 110 029
Indian J Physiol Pharmacol 48:286-92. 2004..However, since up to one-third of the population may be hyperresponders, knowing the response of an individual is important before making the egg a regular item of the diet...
- Hypochlorite-modified (lipo)proteins are present in rabbit lesions in response to dietary cholesterolE Malle
Institute of Medical Biochemistry and Molecular Biology, Karl Franzens University, Graz, A 8010, Austria
Biochem Biophys Res Commun 289:894-900. 2001..We propose that monocyte-derived MPO could connect chronic inflammatory conditions with arterial lipid/lipoprotein deposition during diet-induced atherogenesis in rabbits...
- Eggs and heart disease risk: perpetuating the misperceptionDonald J McNamara
Am J Clin Nutr 75:333-5. 2002
- Dietary cholesterol enhances torpor in a rodent hibernatorF Geiser
Department of Zoology, University of Washington, Seattle 98195, USA
J Comp Physiol B 167:416-22. 1997b>Dietary cholesterol can affect both body lipid composition and steroid hormone concentration...
- Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigsPeter Verhamme
Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
Cardiovasc Res 56:135-44. 2002To study the effect of dietary cholesterol withdrawal on size and composition of LDL-hypercholesterolemia-induced coronary plaques in miniature pigs.
- Dietary cholesterol modulates the excitability of rabbit hippocampal CA1 pyramidal neuronsDesheng Wang
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV 26506, United States
Neurosci Lett 479:327-31. 2010Previous work has shown high dietary cholesterol can affect learning and memory including rabbit eyeblink conditioning and this effect may be due to increased membrane cholesterol and enhanced hippocampal amyloid beta production...
- Dietary cholesterol and atherosclerosisD J McNamara
Egg Nutrition Center, 1050 17th St NW, Suite 560, Washington, DC 20036, USA
Biochim Biophys Acta 1529:310-20. 2000The perceived relationship between dietary cholesterol, plasma cholesterol and atherosclerosis is based on three lines of evidence: animal feeding studies, epidemiological surveys, and clinical trials...
- The protective role of Chinese prescription Kangen-karyu extract on diet-induced hypercholesterolemia in ratsTakako Yokozawa
Institute of Natural Medicine, University of Toyama, Sugitani, Japan
Biol Pharm Bull 29:760-5. 2006..The present study suggests that Kangen-karyu could play a protective role against hypercholesterolemia through the regulation of cholesterol levels and inhibition of lipid peroxidation...
- Hepatic HMG-CoA reductase expression and resistance to dietary cholesterolGene C Ness
Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
Exp Biol Med (Maywood) 229:412-6. 2004..A (HMG-CoA) reductase determines the relative sensitivity to the serum cholesterol raising action of dietary cholesterol was examined in 9 strains of rat. For further comparison purposes, hamsters were also examined...
- Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern MexicoMartha Nydia Ballesteros
Centro de Investigacion y Desarrollo AC, Hermosillo, Sonora, Mexico
Am J Clin Nutr 80:855-61. 2004..An increased incidence of coronary artery disease (CAD) is prevalent in northern Mexico. Effects of specific dietary components on risk factors for CAD have not been evaluated in children...
- Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21S B Patel
Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9052, USA
J Clin Invest 102:1041-4. 1998The molecular mechanisms regulating the amount of dietary cholesterol retained in the body as well as the body's ability to selectively exclude other dietary sterols are poorly understood...
- Dietary cholesterol reduces lipoprotein lipase activity in the atherosclerosis-susceptible Bio F(1)B hamsterMartina A McAteer
Division of Nutritional Biochemistry, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK
Br J Nutr 89:341-50. 2003....
- Men classified as hypo- or hyperresponders to dietary cholesterol feeding exhibit differences in lipoprotein metabolismKristin L Herron
Department of Nutritional Sciences, University of Connecticut, Storrs 06269, USA
J Nutr 133:1036-42. 2003..of normolipidemic men, classified on the basis of their response to prolonged consumption of additional dietary cholesterol. Using a crossover design, 40 men aged 18-57 y were randomly allocated to an egg (640 mg/d additional ..
- Astrocytosis, microgliosis, metallothionein-I-II and amyloid expression in high cholesterol-fed rabbitsPaolo Zatta
CNR Center on Metalloproteins, Department of Biology, University of Padova, Italy
J Alzheimers Dis 4:1-9. 2002..The relevance on the cholesterol metabolism in Alzheimer's disease pathogenesis is also discussed...
- Enhancing effect of dietary cholesterol and inhibitory effect of pravastatin on allergic pulmonary inflammationYa Fan Yeh
Institute of Public Health, National Yang Ming University, Taipei, Taiwan
J Biomed Sci 11:599-606. 2004..the link between the intake of animal fat and asthma, a murine model was developed to examine the effect of dietary cholesterol on pulmonary allergic inflammation...
- Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health StudyLuc Djousse
Division of Aging, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston MA 02120, USA
Am J Clin Nutr 87:964-9. 2008A reduction in dietary cholesterol is recommended to prevent cardiovascular disease (CVD)...
- Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit modelMichael T Johnstone
Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, RW 453, Boston, MA 02115, USA
Circulation 110:2060-5. 2004..This study evaluated the effect of angiotensin receptor blockade on both the development of atherosclerosis and the disruption of plaque in a modified Constantinides animal model...
- Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic ratsO A Adaramoye
Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria
Clin Exp Pharmacol Physiol 32:40-6. 2005..This reduction and the favourable lipid profile indicate a possible anti-atherogenic property of the extract...
- Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterolManal Zabalawi
Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
Am J Pathol 163:1201-13. 2003....
- A review of scientific research and recommendations regarding eggsStephen B Kritchevsky
Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Am Coll Nutr 23:596S-600S. 2004..This concern is based on three observations: 1. eggs are a rich source of dietary cholesterol; 2. when fed experimentally, dietary cholesterol increases serum cholesterol and; 3...
- De Novo induction of atherosclerosis by Chlamydia pneumoniae in a rabbit modelI W Fong
Departments of Medicine, St Michael s Hospital, University of Toronto, Toronto, Canada
Infect Immun 67:6048-55. 1999..pneumoniae. These data are compatible with de novo induction of atherogenesis by C. pneumoniae in rabbits and suggest that C. pneumoniae may be important in the pathogenesis of atherosclerosis in humans...
- Egg consumption, serum cholesterol, and cause-specific and all-cause mortality: the National Integrated Project for Prospective Observation of Non-communicable Disease and Its Trends in the Aged, 1980 (NIPPON DATA80)Yasuyuki Nakamura
Division of Cardiology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan
Am J Clin Nutr 80:58-63. 2004..Because egg yolk has a high cholesterol concentration, limited egg consumption is often suggested to help prevent ischemic heart disease (IHD)...
- The impact of egg limitations on coronary heart disease risk: do the numbers add up?D J McNamara
Egg Nutrition Center, Washington, DC 20036, USA
J Am Coll Nutr 19:540S-548S. 2000..The "dietary cholesterol equals blood cholesterol" view is a standard of dietary recommendations, yet few consider whether the ..
- Maintenance of the LDL cholesterol:HDL cholesterol ratio in an elderly population given a dietary cholesterol challengeChristine M Greene
Departments of Nutritional Science, University of Connecticut, Storrs, CT 06269, USA
J Nutr 135:2793-8. 2005We previously evaluated the responses to dietary cholesterol in children and young adults...
- Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intakeKristin L Herron
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Atherosclerosis 184:113-20. 2006..The presence of individual alleles in this population was associated with differences in plasma lipids and LDL size. However, these relationships were independent of dietary cholesterol.
- Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populationsMaria Luz Fernandez
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut 06269, USA
Curr Opin Clin Nutr Metab Care 9:8-12. 2006..The effects of egg intake on plasma lipids and low-density lipoprotein (LDL) atherogenicity in healthy populations need to be addressed...
- MRI of early- and late-stage arterial remodeling in a low-level cholesterol-fed rabbit model of atherosclerosisJohn A Ronald
Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
J Magn Reson Imaging 26:1010-9. 2007..To monitor early- and late-stage arterial remodeling following low-level cholesterol (CH) feeding in rabbits using a standardized MRI protocol...
- Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in ApoE-deficient miceIkuyo Ichi
Department of Food Science and Nutrition, Nara Women s University, Nara 630 8506, Japan
Lipids 42:893-900. 2007..In apoE-/- mice, dietary cholesterol significantly increased several ceramides and degradation products of apoB in plasma compared to those fed ..
- Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposureP H Groot
Department of Vascular Biology, SmithKline Beecham Pharmaceuticals, Welwyn, Hertfordshire, UK
Arterioscler Thromb Vasc Biol 16:926-33. 1996..On the basis of these findings, we suggest that the APOE*3 Leiden mouse represents a promising model for intervention studies with hypolipidemic and antiatherosclerotic drugs...
- Defatted avocado pulp reduces body weight and total hepatic fat but increases plasma cholesterol in male rats fed diets with cholesterolEinat Naveh
Department of Food Engineering and Biotechnology, Technion, Israel
J Nutr 132:2015-8. 2002..Regardless of dietary cholesterol, hepatic total fat levels, as evaluated histologically, but not directly, were lower in avocado-fed rats...
- Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysisRobert Kleemann
Department of Vascular and Metabolic Diseases, TNO Quality of Life, Biosciences, Gaubius Laboratory, Zernikedreef 9, 2333 CK Leiden, The Netherlands
Genome Biol 8:R200. 2007Increased dietary cholesterol intake is associated with atherosclerosis. Atherosclerosis development requires a lipid and an inflammatory component. It is unclear where and how the inflammatory component develops...
- Orlistat inhibits dietary cholesterol absorptionB Mittendorfer
Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Obes Res 9:599-604. 2001..Therefore, we evaluated the effect of orlistat treatment on dietary cholesterol absorption as a possible mechanism for the independent effect of orlistat on plasma cholesterol ..
- Does p-glycoprotein play a role in gastrointestinal absorption and cellular transport of dietary cholesterol?C Leon
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, B C, Canada
Drug Dev Ind Pharm 32:779-82. 2006..the potential role of p-glycoprotein (Pgp) on the gastrointestinal absorption and cellular transport of dietary cholesterol. This is currently a controversial issue due to the conflicting evidence about the role of this ABC ..
- Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed ratsJen Ying Deng
Department of Life Science, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
Am J Physiol Heart Circ Physiol 293:H978-87. 2007..The cardiac metabolic alterations that impair contractile functions may lead to the development of cardiomyopathy...
- Study of garlic extracts and fractions on cholesterol plasma levels and vascular reactivity in cholesterol-fed ratsK Slowing
Department of Pharmacology, School of Pharmacy, Complutense University, 28040 Madrid, Spain
J Nutr 131:994S-9S. 2001..These data suggest that garlic fractions could prevent diet-induced hypercholesterolemia and vascular alterations in the endothelium-dependent relaxation associated with atherosclerosis...
- Dietary cholesterol absorption; more than just bileK Lu
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
Trends Endocrinol Metab 12:314-20. 2001Absorption of dietary cholesterol from the intestine is an important part of cholesterol homeostasis and represents the first step that allows dietary cholesterol to exert its metabolic effects...
- Protective effects of vitamin E and selenium on the renal morphology in rats fed high-cholesterol dietsS Gonca
Department of Histology Embryology, Kocaeli University Faculty of Medicine, Derince, Kocaeli, Turkey
Pathobiology 68:258-63. 2000..In addition, it was concluded that antioxidant therapy may prevent LDL oxidation and generation of free radicals...
- Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosisAnna Rull
Centre de Recerca Biomedica, Hospital Universitari Sant Joan de Reus, IISPV, Universitat Rovira i Virgili, C Sant Joan s n, 43201 Reus, Spain
Cytokine 48:273-9. 2009..We conclude that dietary cholesterol upregulation of hepatic MCP-1 may help to understand the role of circulating MCP-1 in conditions where ..
- Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol HomeostasisKamal D Mehta; Fiscal Year: 2010..The plasma levels of LDL are strongly influenced by dietary cholesterol and body's ability to store and metabolize ingested cholesterol...
- Dietary Cholesterol and Defects in Cholesterol SynthesisROBERT DAVID STEINER; Fiscal Year: 2013..Together, the in vivo and in vitro studies proposed should shed light on the pathogenesis of SLOS, and offer insights into treatment that to date have eluded investigators. ..
- Regulation of Metabolism by Dietary SterolsSHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013..The pathway how our bodies regulate dietary cholesterol was elucidated by our recent work on a genetic disorder, sitosterolemia, which is associated with premature ..
- The role of caveolin 1 in intestinal lipid processing and transportJESSICA OTIS; Fiscal Year: 2013..efflux to high-density lipoproteins (HDL);mice lacking CAV1 have altered plasma lipids despite normal dietary cholesterol absorption. Thus, intestinal caveolae may play a role in lipid metabolism and cardiovascular disease...
- Inflammation, Atherosclerosis and ApoA-IMary G Sorci-Thomas; Fiscal Year: 2013..Regardless of the level of dietary cholesterol, DKO mice consistently showed lower plasma cholesterol than SKO mice, yet greater aortic cholesterol ..
- Effect of Nutritional Factors on Macrophage Accumulation in Adipose TissueAlan Chait; Fiscal Year: 2012..These nutritional factors include glucose excess, certain saturated fatty acids and dietary cholesterol (or oxysterols that result from cholesterol oxidation in foods)...
- Intralumental Effect on Cholesterol Absorption/SynthesisJames Heubi; Fiscal Year: 2009..the intraluminal solubilization and distribution within micelles and vesicles of biliary compared to dietary cholesterol in humans and assess the impact of ezetimibe treatment on absorption of endogenous or exogenous cholesterol ..
- Cholesterol and copper affect learning and memoryBernard G Schreurs; Fiscal Year: 2013..This work is important because of the impact it will have on understanding the role of dietary cholesterol and beta amyloid deposits in learning and memory and on our understanding of the pathogenesis of failures ..
- Co-localizing Quantitative Trait Loci for Bone Mineral Density and HDL in MiceCHERYL LYNNE ACKERT-BICKNELL; Fiscal Year: 2013..Furthermore, both of these BMD QTL interact with dietary cholesterol intake...
- Cholesterol_fat_absorptionEphraim Sehayek; Fiscal Year: 2013DESCRIPTION (provided by applicant): The absorption of dietary cholesterol and fat from the intestine are important modifiers of plasma cholesterol level, adiposity, and risk for atherosclerotic cardiovascular diseases...
- Fetal Lead Exposure, Genes, and NeurodevelopmentHoward Hu; Fiscal Year: 2010..impact on behavior and that assess the potential for measures of maternal circulating cholesterol, maternal dietary cholesterol, and infant 24S-hydroxy cholesterol (a novel plasma biomarker of CNS cholesterol) to modify the lead-gene ..
- Atherogenic Induction of NeuroinflammationNarayan R Bhat; Fiscal Year: 2010..The specific objectives are to determine if the kinase depletion and pharmacological intervention reduce dietary cholesterol-induced neuroinflammation and increased amyloid deposition in the APPTg mice with the outcome of an ..
- Sterol and Coenzyme Q metabolism in C. elegansFernando Gomez; Fiscal Year: 2010..Nematodes are unable to synthesize sterols de novo, and rely on dietary cholesterol for their sterol needs...
- DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISMD Illingworth; Fiscal Year: 1991..four diets will be fed to subjects consuming a cholesterol-free diet and in the presence of 600 mg/day of dietary cholesterol. The metabolic effects of long chain polyunsaturated fatty acids derived from fish oil will be examined in ..
- REVERSE CHOLESTEROL TRANSPORT IN HUMANSRichard E Ostlund; Fiscal Year: 2013..a different oral tracer, to partition fecal cholesterol into excreted endogenous cholesterol, unabsorbed dietary cholesterol and newly-synthesized cholesterol derived from the liver and intestine...
- DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINSPHYLLIS MCPHERSON; Fiscal Year: 1990Controlled dietary studies will be carried out in 40 Caucasian males to determine the effects of dietary cholesterol on the apolipoprotein and lipid composition of plasma lipoprotein subfractions and the plasma phosphatidylcholine/free ..
- PREMATURE WEANING AND ADULT CHOLESTEROL HOMEOSTASISDONALD MC NAMARA; Fiscal Year: 1993..by premature weaning on the homeostatic responses to changes in dietary fat (corn oil versus lard) and in dietary cholesterol. Studies will determine the effects on the regulation of hepatic and extrahepatic sterol synthesis (hepatic ..
- STEROL METABOLISM & DIETARY CHOLESTEROL IN SLO SYNDROMEWILLIAM CONNOR; Fiscal Year: 2002..The principal investigator (PI) has proposed to feed dietary cholesterol from three different sources, egg yolk, crystalline cholesterol and butterfat to SLOS patients...
- EXPRESSION OF APOLIPOPROTEIN GENES IN TRANSGENIC RABBITSJohn Taylor; Fiscal Year: 2001..The rabbit is used as the experimental model because of its exaggerated response to dietary cholesterol, its sensitivity to apoE levels, and its distinct phenotypes upon transgene expression...
- LIPID AND LIPOPROTEIN METABOLISM IN INSECTSMichael Wells; Fiscal Year: 2005..b>Dietary cholesterol, or sterols that can be converted to cholesterol, are critical for insects because they cannot make sterols ..
- PROSPECTIVE STUDY OF DIET AND CARDIOVASCULAR DISEASEJiang He; Fiscal Year: 1999Cardiovascular disease is the leading cause of death among residents of the United States. The effect of dietary cholesterol and fat on risk of coronary heart disease (CHD) and stroke has been examined extensively in epidemiologic ..
- Irreversible inhibitors of cholesterol esteraseLORRAINE DECK; Fiscal Year: 2005Pancreatic cholesterol esterase (CE) has a dual function in the absorption of dietary cholesterol. First, CE catalyzes the hydrolysis of cholesterol esters to liberate cholesterol for absorption; second, CE transports cholesterol from ..
- EPIDEMIOLOGY OF PLASMA FATTY ACIDS AND ATHEROSCLEROSISJohn Eckfeldt; Fiscal Year: 1991..S. and all other industrialized nations. High dietary cholesterol is now well recognized as a major atherosclerotic risk factor...
- SYNTHESIS OF HELMINTHOSPOROL ANALOGS AS ACAT INHIBITORSEDUARD CASILLAS; Fiscal Year: 2004..Therefore, ACAT may play an important role in the absorption of dietary cholesterol. An efficient ACAT inhibitor has the potential to function therapeutically as an anti-atherosclerotic agent ..
- MECHANISM OF ESTROGEN EFFECTS ON BILIARY CHOLESTEROLFRED KERN; Fiscal Year: 1991..Plasma apoprotein A-I and B will be measured by ELISA in both studies. An additional hypothesis that dietary cholesterol contributes to the pathogenesis of cholesterol gallstone in some subjects will be tested by measuring the ..
- CELL MUTANTS DEFECTIVE IN CHOLESTEROL ESTER FORAMTIONTa Yuan Chang; Fiscal Year: 2003..to play significant roles in lipoprotein assembly and secretion, in steroid hormone production, and in dietary cholesterol absorption...
- CHOLESTEROL-RICH DIET AND PLASMA LIPID TRANSPORTWolfgang Patsch; Fiscal Year: 1991..may be challenged because of heterogeneity in the genetic makeup influencing an individual's response to dietary cholesterol. The goals of this proposal are i) to define the principal mechanism(s) which determine the reaction of the ..
- HUMAN CHOLESTEROL METABOLISM--NEW METHODS ACUTE STUDIESDale Schoeller; Fiscal Year: 1993..One factor known to increase plasma cholesterol level is dietary cholesterol intake, however, not all individuals increase plasma cholesterol levels in response to cholesterol intake...
- CHOLESTEROL METABOLISM IN ATHEROSCLEROSIS RESISTANCEMERRILL OVERTURF; Fiscal Year: 1990The New Zealand rabbit is a species that is characteristically sensitive to dietary cholesterol and rapidly develops hypercholesterolemia and atherosclerosis...
- ABCs of Intestinal Sterol TransportF Field; Fiscal Year: 2009..rafts in apical sterol transport;and the regulation of ABC transporters and NPC1L1 in hamster intestine by dietary cholesterol, plant sterols, or fat...
- EFFECTS OF LIFESTYLE CHANGES ON CORONARY HEART DISEASEDean Ornish; Fiscal Year: 1992..To date, 17 patients have completed testing at baseline and after one year. In the experimental group, dietary cholesterol had decreased from 215.0 for 2.6 mg/day and total dietary fat has decreased from 70.0 to 15...
- CATABOLISM AND EXCRETION OF CHOLESTEROL AND BILE ACIDSDavid Loose; Fiscal Year: 2002..The goal of this proposal is to determine how two key pathways of bile acid biosynthesis are regulated by dietary cholesterol and to determine the mechanisms regulating the apical Na+ -dependent bile-acid transport protein (ASBP) in ..
- Genes, Hormones & Environment in an Ovarian Cancer ModelDaniel Cramer; Fiscal Year: 2007..Steroid production is also enhanced by caffeine use, a predicted risk factor interacting with dietary cholesterol or caffeine metabolism...
- Behavioral factors and dietary change in WHTFSMPAlok Bhargava; Fiscal Year: 2003..Behavioral factors, anthropometric indicators, energy derived from saturated and polyunsaturated fats, and dietary cholesterol will be explanatory variables in models for plasma LDL cholesterol...
- REGULATION OF AMYLOID BETA PROTEIN BY APOE & CHOLESTEROLBruce Yankner; Fiscal Year: 2004..elucidate the role of apoE in the metabolism of AB and amyloid precursor protein (APP) and its control by dietary cholesterol. The studies in this proposal are based on the working hypothesis that the absolute level of apoE is a ..
- EFFECTS OF DIETARY CHOLESTEROL ON LIPOPROTEIN METABOLISMRAMPRATAP KUSHWAHA; Fiscal Year: 1991..the metabolic and molecular mechanisms by which individuals in a population respond differently to dietary cholesterol and how dietary fat modulates this response...
- EFFECTS OF LIFESTYLE CHANGES ON CORONARY HEART DISEASEK Gould; Fiscal Year: 1992..In the experimental group, dietary cholesterol has decreased from 215.0 to 2.6 mg/day and total dietary fat has decreased from 70.0 to 15...
- GENETIC AND BIOMEDICAL STUDIES OF SITOSTEROLEMIAShailendra Patel; Fiscal Year: 2003..One of these risk factors is cholesterol. Understanding the factors that normally regulate net dietary cholesterol intake may allow us to reduce the impact of this risk factor...
- CHOLESTEROL METABOLISM--BIOLOGIC ROLE OF 27 HYDROXYLATIONorman Javitt; Fiscal Year: 2000..rabbits recent data implying that the cholesterol 27-hydroxylase pathway is specific for the metabolism of dietary cholesterol to bile acids...
- DETECTION OF LDL-RECEPTORS IN COLON AND COLON TUMORSSELWYN BROITMAN; Fiscal Year: 1991..b>Dietary cholesterol contributes to risk for colon cancer epidemiologically and experimentally, but little is known of ..
- DIET EFFECTS--LIPOPROTEIN METABOLISM & PLATELET FUNCTIONHenry Ginsberg; Fiscal Year: 1990..effects of a diet containing 30% fat with those of a 20% fat diet; 3) compare the effects of 3 levels of dietary cholesterol (500 mg, 250 mg, and 100 mg per day); and 4) compare the effects of omega-3 and omega-6 fatty acid...
- MOLECULAR MECHANISMS OF CHOLESTEROL ABSORPTIONDavid Hui; Fiscal Year: 2003..Because high dietary cholesterol intake is a major risk factor for heart disease, diabetes, obesity, and certain forms of cancer, results of ..
- DIETARY CHOLESTEROL EFFECTS ON LIPOPROTEIN METABOLISMLawrence Rudel; Fiscal Year: 1992In some individuals, an elevation in dietary cholesterol intake causes hypercholesterolemia and an increased risk of premature coronary heart disease (CHD)...
- SPECIALIZED CENTER OF RESEARCH IN ARTERIOSCLEROSISRICHARD ST CLAIR; Fiscal Year: 1991..on genetic and biochemical mechanisms in determining hypo or hyperresponsiveness of nonhuman primates to dietary cholesterol, comparative studies of pleomorphic features of fatty streaks, studies on endothelial permeability, lesion ..
- Gene-diet interactions and dietary cholesterol responseJan Breslow; Fiscal Year: 2005b>Dietary cholesterol and saturated fatty acids raise LDL cholesterol levels and atherosclerotic cardiovascular disease risk...
- Cholesterol and Prostate Cancer ProgressionKeith Solomon; Fiscal Year: 2007..This application responds to the RFA by directly evaluating the effect of dietary cholesterol on prostate tumor progression and the ability of membrane cholesterol to regulate the ErbB/PI3K/Akt anti-..
- DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINSChristopher Fielding; Fiscal Year: 1991Increased dietary cholesterol and saturated fat have been shown to be related to increased levels of plasma cholesterol (particularly in low density lipoproteins) and vascular disease...
- LIPID VARIABILITY--INFLUENCE OF STRESSJames Raczynski; Fiscal Year: 1992..affect lipids: dietary intake (including alcohol, caffeine, total calories, total fat, saturated fat, and dietary cholesterol), smoking, and physical activity, and oral contraceptive use, pregnancy status and menstrual stage among ..
- RURAL LIPID RESOURCE CENTER--A PHYSICIAN-ASSIST MODELRoberta Reed; Fiscal Year: 1993..on appropriate drug) and outcome (change in % of total calories as fat and saturated fat, milligrams of dietary cholesterol, mg/di reduction in LDL cholesterol levels, and cost of intervention)...
- Feedback and Hormonal Regulation of Hepatic HMG-CoA ReductaseGENE CHARLES NESS; Fiscal Year: 2010..studies demonstrating that intrinsic resistance to the serum and tissue cholesterol raising action of dietary cholesterol is proportional to the level of expression of hepatic HMGR make knowledge of the physiological mechanisms ..
- Conditioning-specific reflex modificationBERNARD SCHREURS; Fiscal Year: 2004..abstract_text> ..
- Mineralization studies related to atherosclerosisHOWARD HSU; Fiscal Year: 2004..abstract_text> ..
- Hyperglycemia, Aldose Reducatse & Murine AtherosclerosisIra Goldberg; Fiscal Year: 2005..This is significant because it will provide for a model to study this complication and suggest a therapeutic target for prevention of diabetic macrovascular disease. ..
- TREATMENT PREFERENCE AND VEGETARIAN DIET IN WEIGHT LOSSLora Burke; Fiscal Year: 2005..Additionally, the study will provide information on the role of treatment preference, its effect on behavioral and clinical outcomes, and participants' characteristics by treatment preference. ..
- Chromium Effects in Imparied Glucose ToleranceDavid Katz; Fiscal Year: 2006..By contributing to knowledge related to potential diabetes prevention strategies, this study addresses one of the more pressing public health issues in the US today. ..
- Atherogenic Effects of Tyrosine Oxidation in HDLJohn Oram; Fiscal Year: 2004....
- Improving Self-Monitoring in Weight Loss with TechnologyLora E Burke; Fiscal Year: 2010..Subjects will complete assessments at baseline, 6, 12, 18, and 24 months. This innovative study will provide information on the efficacy of combining technological advances with proven behavioral strategies. ..
- IVMT for Fibromyalgia Syndrome: A Pilot StudyDavid Katz; Fiscal Year: 2004..The identification of an effective, safe, inexpensive therapy for fibromyalgia would represent a great advance, and a major contribution to the public health. ..
- ATHEROGENICITY OF APOB CONTAINING LIPOPROTEINSIra Goldberg; Fiscal Year: 2003..Moreover, the experiments are significant for our understanding of atherosclerosis development and may demonstrate molecular methods to alter apoB retention that could be used in treatment and preventative therapies. ..
- Long-term changes in weight and adipokines and the associations with genetic variLora E Burke; Fiscal Year: 2010..The proposed study and mentoring strategies will be placed in the context of an area of NINR emphasis - promoting health and preventing disease as it addresses a highly prevalent chronic disorder - overweight and obesity. ..