cholesterol

Summary

Summary: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.

Top Publications

  1. ncbi Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    Scott W Altmann
    Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
    Science 303:1201-4. 2004
  2. doi Lipid rafts as a membrane-organizing principle
    Daniel Lingwood
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Science 327:46-50. 2010
  3. pmc NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    Peter Duewell
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1357-61. 2010
  4. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
  5. ncbi Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    R W Mahley
    Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
    Science 240:622-30. 1988
  6. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
  7. pmc MiR-33 contributes to the regulation of cholesterol homeostasis
    Katey J Rayner
    Department of Medicine, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
    Science 328:1570-3. 2010
  8. ncbi The MARTINI force field: coarse grained model for biomolecular simulations
    Siewert J Marrink
    Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, Department of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Phys Chem B 111:7812-24. 2007
  9. pmc Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
    Jan E Carette
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 477:340-3. 2011
  10. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992

Detail Information

Publications310 found, 100 shown here

  1. ncbi Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    Scott W Altmann
    Department of Cardiovascular Endocrine Research, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ, 07033 0539, USA
    Science 303:1201-4. 2004
    Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for coronary heart disease...
  2. doi Lipid rafts as a membrane-organizing principle
    Daniel Lingwood
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Science 327:46-50. 2010
    ..Lipid rafts are fluctuating nanoscale assemblies of sphingolipid, cholesterol, and proteins that can be stabilized to coalesce, forming platforms that function in membrane signaling and ..
  3. pmc NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    Peter Duewell
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1357-61. 2010
    ..Mature atherosclerotic lesions contain macroscopic deposits of cholesterol crystals in the necrotic core, but their appearance late in atherogenesis had been thought to disqualify them ..
  4. ncbi Prediction of coronary heart disease using risk factor categories
    P W Wilson
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Mass 01701, USA
    Circulation 97:1837-47. 1998
    ..of this study was to examine the association of Joint National Committee (JNC-V) blood pressure and National Cholesterol Education Program (NCEP) cholesterol categories with coronary heart disease (CHD) risk, to incorporate them ..
  5. ncbi Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
    R W Mahley
    Gladstone Foundation Laboratories for Cardiovascular Disease, University of California, San Francisco 94140 0608
    Science 240:622-30. 1988
    ..lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body...
  6. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    Previous trials have demonstrated that lowering low-density lipoprotein (LDL) cholesterol levels below currently recommended levels is beneficial in patients with acute coronary syndromes...
  7. pmc MiR-33 contributes to the regulation of cholesterol homeostasis
    Katey J Rayner
    Department of Medicine, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
    Science 328:1570-3. 2010
    b>Cholesterol metabolism is tightly regulated at the cellular level...
  8. ncbi The MARTINI force field: coarse grained model for biomolecular simulations
    Siewert J Marrink
    Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, Department of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    J Phys Chem B 111:7812-24. 2007
    ..Application to a bilayer/cholesterol system at various concentrations shows the typical cholesterol condensation effect similar to that observed in ..
  9. pmc Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
    Jan E Carette
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 477:340-3. 2011
    ..involved in the fusion of endosomes to lysosomes, and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter protein Niemann-Pick C1 (NPC1)...
  10. ncbi Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
    A S Plump
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021 6399
    Cell 71:343-53. 1992
    apoE-deficient mice have been created by homologous recombination in ES cells. On a low fat, low cholesterol chow diet these animals have plasma cholesterol levels of 494 mg/dl compared with 60 mg/dl in control animals, and when ..
  11. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
    Proper coordination of cholesterol biosynthesis and trafficking is essential to human health...
  12. ncbi Lipid rafts and signal transduction
    K Simons
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 1:31-9. 2000
    ..Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades...
  13. ncbi The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    M S Brown
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Cell 89:331-40. 1997
  14. ncbi Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
    M Drab
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauer Strasse 108, D 01307 Dresden, Germany
    Science 293:2449-52. 2001
    ..Thus, caveolin-1 and caveolae play a fundamental role in organizing multiple signaling pathways in the cell...
  15. ncbi Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Münster (PROCAM) study
    Gerd Assmann
    Institute of Arteriosclerosis Research at the University of Münster, Germany
    Circulation 105:310-5. 2002
    ..Although several scoring schemes have been suggested to calculate this profile, many omit information on important variables such as family history of coronary heart disease or LDL cholesterol.
  16. ncbi Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians?
    Chee Eng Tan
    Department of Endocrinology, Singapore General Hospital, Singapore, Republic of Singapore
    Diabetes Care 27:1182-6. 2004
    ..The objectives of this study were to determine the optimal waist circumference for diagnosing central obesity in Asians and to estimate the prevalence of the metabolic syndrome in an Asian population...
  17. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  18. doi Brain cholesterol in normal and pathological aging
    Mauricio Martin
    Department of Molecular and Developmental Genetics, VIB, 3000 Leuven, Belgium
    Biochim Biophys Acta 1801:934-44. 2010
    ..These are critically challenged in the aging brain. Changes in the levels of cholesterol, a major membrane component especially enriched in neurons, accompany the brain aging process...
  19. pmc A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor
    Michael A Hanson
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Structure 16:897-905. 2008
    The role of cholesterol in eukaryotic membrane protein function has been attributed primarily to an influence on membrane fluidity and curvature. We present the 2...
  20. pmc Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis
    Amit V Khera
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, USA
    N Engl J Med 364:127-35. 2011
    High-density lipoprotein (HDL) may provide cardiovascular protection by promoting reverse cholesterol transport from macrophages...
  21. pmc High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    Vadim Cherezov
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 318:1258-65. 2007
    ..b>Cholesterol, a necessary component for crystallization, mediates an intriguing parallel association of receptor molecules ..
  22. ncbi Functions of lipid rafts in biological membranes
    D A Brown
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215, USA
    Annu Rev Cell Dev Biol 14:111-36. 1998
    ..Instead, sphingolipid and cholesterol-rich membranes such as plasma membranes appear to exist, at least partially, in the liquid-ordered phase or a ..
  23. pmc SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    Jay D Horton
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 109:1125-31. 2002
  24. pmc Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease
    Hae Ki Min
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Cell Metab 15:665-74. 2012
    ..NAFLD is characterized by both triglyceride and free cholesterol (FC) accumulation without a corresponding increment in cholesterol esters...
  25. pmc Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches
    Anton I Rosenbaum
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065, USA
    J Neurochem 116:789-95. 2011
    b>Cholesterol is an important lipid of mammalian cells. Its unique physicochemical properties modulate membrane behavior and it serves as the precursor for steroid hormones, oxysterols and vitamin D...
  26. pmc Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
    Robert Ehehalt
    Max Planck Institute of Molecular Cell Biology and Genetics, D 01307 Dresden, Germany
    J Cell Biol 160:113-23. 2003
    ..Here, we demonstrate that lipid rafts are critically involved in regulating A beta generation. Reducing cholesterol levels in N2a cells decreased A beta production...
  27. ncbi CNS synaptogenesis promoted by glia-derived cholesterol
    D H Mauch
    Synapse Group and, Protein Chemistry Group, , D-13092 Berlin, Germany
    Science 294:1354-7. 2001
    ..Here, we identify this factor as cholesterol complexed to apolipoprotein E-containing lipoproteins...
  28. pmc RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42
    Benjamin Misselwitz
    Institute of Microbiology, D BIOL, ETH Zurich, Zurich, Switzerland
    Mol Syst Biol 7:474. 2011
    ..Both effects are attributable to mislocalization of cholesterol, sphingolipids, Rac1 and Cdc42 away from the plasma membrane into a large intracellular compartment...
  29. pmc Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations
    Jennifer E Griffin
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Chem Biol 19:218-27. 2012
    ..we used comprehensive metabolite profiling to identify the biochemical pathways utilized during growth on cholesterol, a critical carbon source during chronic infection...
  30. pmc High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
    Jennifer E Griffin
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Pathog 7:e1002251. 2011
    ..that are required for persistence in the host, we defined the pathways necessary for the utilization of cholesterol, a critical carbon source during infection...
  31. pmc Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
    Joanna Rejman
    Department of Membrane Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Biochem J 377:159-69. 2004
    ..With an increase in size (50-500 nm), cholesterol depletion increased the efficiency of inhibition of uptake...
  32. ncbi Silencing of microRNAs in vivo with 'antagomirs'
    Jan Krutzfeldt
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 438:685-9. 2005
    ..Analysis of the functional annotation of downregulated genes specifically predicted that cholesterol biosynthesis genes would be affected by miR-122, and plasma cholesterol measurements showed reduced levels in ..
  33. ncbi Structural basis of pore formation by the bacterial toxin pneumolysin
    Sarah J Tilley
    School of Crystallography and Institute of Structural Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, United Kingdom
    Cell 121:247-56. 2005
    ..as a soluble monomer that kills target cells by assembling into large oligomeric rings and forming pores in cholesterol-containing membranes...
  34. pmc Mycobacterial persistence requires the utilization of host cholesterol
    Amit K Pandey
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655
    Proc Natl Acad Sci U S A 105:4376-80. 2008
    ..We now show that mce4 encodes a cholesterol import system that enables M...
  35. pmc LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    Noam Zelcer
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095, USA
    Science 325:100-4. 2009
    Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis...
  36. pmc Xenobiotic, bile acid, and cholesterol transporters: function and regulation
    Curtis D Klaassen
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160 7417, USA
    Pharmacol Rev 62:1-96. 2010
    ..Transporters are important transmembrane proteins that mediate the cellular entry and exit of a wide range of substrates throughout the body and thereby play important roles in human physiology, pharmacology, pathology, and toxicology...
  37. pmc Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    Daniel I Chasman
    Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000730. 2009
    ..Associations with mean lipoprotein particle size but not cholesterol content were found for LDL at four loci (7q11.23, LPL (8p21.3), 12q24.31.B, and LIPG (18q21...
  38. pmc Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons
    M Simons
    Cell Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10 2209, D 69012 Heidelberg, Germany
    Proc Natl Acad Sci U S A 95:6460-4. 1998
    ..By reducing the cellular cholesterol level of living hippocampal neurons by 70% with lovastatin and methyl-beta-cyclodextrin, we show that the ..
  39. pmc Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor
    Bruno Sainz
    Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA
    Nat Med 18:281-5. 2012
    ..Here we show that the cellular Niemann-Pick C1-like 1 (NPC1L1) cholesterol uptake receptor is an HCV entry factor amendable to therapeutic intervention...
  40. ncbi miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    Christine Esau
    Isis Pharmaceuticals, 1896 Rutherford Road, Carlsbad, California 92008, USA
    Cell Metab 3:87-98. 2006
    ..miR-122 inhibition in normal mice resulted in reduced plasma cholesterol levels, increased hepatic fatty-acid oxidation, and a decrease in hepatic fatty-acid and cholesterol synthesis ..
  41. doi Thirty-five-year trends in cardiovascular risk factors in Finland
    Erkki Vartiainen
    National Institute for Health and Welfare, Helsinki, Finland
    Int J Epidemiol 39:504-18. 2010
    ..From 1972 to 2007, risk factor surveys have been carried out to monitor risk factor trends and assess their contribution to declining mortality in Finland...
  42. ncbi Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:15-24. 2006
    This paper describes a convergent mechanism for the feedback control of cholesterol synthesis and uptake mediated by SREBPs, membrane bound transcription factors...
  43. ncbi Bile acids: natural ligands for an orphan nuclear receptor
    D J Parks
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development, Research Triangle Park NC, 27709, USA
    Science 284:1365-8. 1999
    Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood...
  44. ncbi Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    D J Peet
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 93:693-704. 1998
    ..that mice lacking the oxysterol receptor, LXR alpha, lose their ability to respond normally to dietary cholesterol and are unable to tolerate any amount of cholesterol in excess of that which they synthesize de novo...
  45. pmc Prediagnostic total and high-density lipoprotein cholesterol and risk of cancer
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 18:2814-21. 2009
    Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized...
  46. pmc Total cholesterol and cancer risk in a large prospective study in Korea
    Cari M Kitahara
    National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    J Clin Oncol 29:1592-8. 2011
    To further clarify the relationship between total cholesterol and cancer, which remains unclear.
  47. pmc Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations
    Nina E Shepardson
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, HIM Room 730, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arch Neurol 68:1385-92. 2011
    Substantial evidence has accumulated in support of the hypothesis that elevated cholesterol levels increase the risk of developing Alzheimer disease (AD)...
  48. pmc Linking lipids to Alzheimer's disease: cholesterol and beyond
    Gilbert Di Paolo
    Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA
    Nat Rev Neurosci 12:284-96. 2011
    ..Although much attention has been given to the link between cholesterol and AD pathogenesis, growing evidence suggests that other lipids, such as phosphoinositides and phosphatidic ..
  49. pmc Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Clin Invest 92:883-93. 1993
    ..Homozygous male and female mice lacking LDL receptors (LDLR-/- mice) were viable and fertile. Total plasma cholesterol levels were twofold higher than those of wild-type litter-mates, owing to a seven- to ninefold increase in ..
  50. ncbi Antiinflammatory properties of HDL
    Philip J Barter
    The Heart Research Institute, 145 Missenden Rd, Camperdown, Sydney 2050, Australia
    Circ Res 95:764-72. 2004
    ..The best recognized of these is the ability of HDL to promote the efflux of cholesterol from cells. This process may minimize the accumulation of foam cells in the artery wall...
  51. pmc Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol
    Hyock Joo Kwon
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell 137:1213-24. 2009
    LDL delivers cholesterol to lysosomes by receptor-mediated endocytosis. Exit of cholesterol from lysosomes requires two proteins, membrane-bound Niemann-Pick C1 (NPC1) and soluble NPC2...
  52. pmc The LDL receptor
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Arterioscler Thromb Vasc Biol 29:431-8. 2009
    ..early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism...
  53. pmc miR-33 links SREBP-2 induction to repression of sterol transporters
    Tyler J Marquart
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 107:12228-32. 2010
    ..SREBP-2) and the liver X receptor (LXR) control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and synthesis, and cholesterol efflux, respectively...
  54. ncbi Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..resistance and central body fat distribution in determining the metabolic syndrome as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III...
  55. pmc The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry
    Samad Amini-Bavil-Olyaee
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Harlyne J Norris Cancer Research Tower, 1450 Biggy Street, Los Angeles, CA 90033, USA
    Cell Host Microbe 13:452-64. 2013
    Vesicle-membrane-protein-associated protein A (VAPA) and oxysterol-binding protein (OSBP) regulate intracellular cholesterol homeostasis, which is required for many virus infections...
  56. doi National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3·0 million participants
    Farshad Farzadfar
    Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA
    Lancet 377:578-86. 2011
    Data for trends in serum cholesterol are needed to understand the effects of its dietary, lifestyle, and pharmacological determinants; set intervention priorities; and evaluate national programmes...
  57. pmc Liver X receptors as integrators of metabolic and inflammatory signaling
    Noam Zelcer
    Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, California 90055 1662, USA
    J Clin Invest 116:607-14. 2006
    ..LXRs function as nuclear cholesterol sensors that are activated in response to elevated intracellular cholesterol levels in multiple cell types...
  58. ncbi An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
    Fajun Yang
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    Nature 442:700-4. 2006
    ..sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis...
  59. doi Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium
    Emyr Lloyd-Evans
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    Nat Med 14:1247-55. 2008
    ..function of NPC1 is unknown, but when it is dysfunctional, sphingosine, glycosphingolipids, sphingomyelin and cholesterol accumulate...
  60. pmc Inflammation impairs reverse cholesterol transport in vivo
    Fiona C McGillicuddy
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 119:1135-45. 2009
    Inflammation is proposed to impair reverse cholesterol transport (RCT), a major atheroprotective function of high-density lipoprotein (HDL)...
  61. ncbi Perinatal and postnatal exposure to bisphenol a increases adipose tissue mass and serum cholesterol level in mice
    Joji Miyawaki
    Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
    J Atheroscler Thromb 14:245-52. 2007
    ..To investigate whether the perinatal and postnatal exposure of mice to bisphenol A (BPA) caused the development of obesity and/or hyperlipidemia...
  62. ncbi Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
    S H Zhang
    Department of Pathology, University of North Carolina, Chapel Hill 27599 7525
    Science 258:468-71. 1992
    ..Lack of apoE is, therefore, expected to cause accumulation in plasma of cholesterol-rich remnants whose prolonged circulation should be atherogenic...
  63. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  64. doi Application of new cholesterol guidelines to a population-based sample
    Michael J Pencina
    From the Duke Clinical Research Institute M J P, B N, E D P, Department of Biostatistics and Bioinformatics M J P, and Division of Cardiology A M N B, Duke University, Durham, NC the Department of Mathematics and Statistics, Boston University and the Harvard Clinical Research Institute both in Boston R B D KenAnCo Biostatistics, San Antonio, TX K W and Royal Victoria Hospital, McGill University, Montreal A D S
    N Engl J Med 370:1422-31. 2014
    The 2013 guidelines of the American College of Cardiology and the American Heart Association (ACC-AHA) for the treatment of cholesterol expand the indications for statin therapy for the prevention of cardiovascular disease.
  65. pmc cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    E G Lund
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9046, USA
    Proc Natl Acad Sci U S A 96:7238-43. 1999
    The turnover of cholesterol in the brain is thought to occur via conversion of excess cholesterol into 24S-hydroxycholesterol, an oxysterol that is readily secreted from the central nervous system into the plasma...
  66. doi Meta-analysis of comparison of effectiveness of lowering apolipoprotein B versus low-density lipoprotein cholesterol and nonhigh-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trials
    Jennifer G Robinson
    University of Iowa, Iowa City, IA, USA
    Am J Cardiol 110:1468-76. 2012
    ..1 on ileal bypass surgery, and 1 on aggressive versus standard low-density lipoprotein (LDL) cholesterol and blood pressure targets...
  67. pmc High-density lipoprotein heterogeneity and function in reverse cholesterol transport
    George H Rothblat
    Gastroenterology, Hepatology and Nutrition Division, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Curr Opin Lipidol 21:229-38. 2010
    HDL is a cardioprotective lipoprotein, at least in part, because of its ability to mediate reverse cholesterol transport (RCT)...
  68. pmc Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro
    Matthew H Sieber
    Department of Human Genetics, University of Utah School of Medicine, 15 N 2030 E, Room 2100, Salt Lake City, UT 84112 5330 USA
    Cell Metab 15:122-7. 2012
    Although transintestinal cholesterol efflux has been identified as an important means of clearing excess sterols, the mechanisms that underlie this process remain poorly understood...
  69. doi Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review
    Terry A Jacobson
    Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Faculty Office Building, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    J Clin Lipidol 6:5-18. 2012
    ..differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and non-HDL-C in published studies ..
  70. pmc Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
    Abdoulaye Sene
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Cell Metab 17:549-61. 2013
    ..Downregulation of ABCA1 by microRNA-33 impairs the ability of macrophages to effectively efflux intracellular cholesterol, which in turn leads to higher levels of free cholesterol within senescent macrophages...
  71. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  72. doi Cholesterol metabolism in neurons and astrocytes
    Frank W Pfrieger
    CNRS UPR 3212, University of Strasbourg, Institute of Cellular and Integrative Neurosciences INCI, 67084 Strasbourg Cedex, France
    Prog Lipid Res 50:357-71. 2011
    Cells in the mammalian body must accurately maintain their content of cholesterol, which is an essential membrane component and precursor for vital signalling molecules...
  73. ncbi ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
    Matthew A Kennedy
    Department of Biological Chemistry, CHS 33 257, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Cell Metab 1:121-31. 2005
    ..plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL...
  74. ncbi Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    L Boring
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141, USA
    Nature 394:894-7. 1998
    ..These data reveal a role for MCP-1 in the development of early atherosclerotic lesions and suggest that upregulation of this chemokine by minimally oxidized lipids is an important link between hyperlipidaemia and fatty streak formation...
  75. doi Remnant cholesterol as a causal risk factor for ischemic heart disease
    Anette Varbo
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    J Am Coll Cardiol 61:427-36. 2013
    The aim of this study was to test the hypothesis that elevated nonfasting remnant cholesterol is a causal risk factor for ischemic heart disease independent of reduced high-density lipoprotein (HDL) cholesterol.
  76. pmc Plasma membrane rafts play a critical role in HIV-1 assembly and release
    A Ono
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 307, 9000 Rockville Pike, Bethesda, MD 20892-0460, USA
    Proc Natl Acad Sci U S A 98:13925-30. 2001
    ..We show here that Gag specifically associates with cholesterol-enriched microdomains ("rafts") at the plasma membrane...
  77. pmc Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice
    Laurent Yvan-Charvet
    Division of Molecular Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 117:3900-8. 2007
    ..HDL and its apolipoproteins can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporters ABCA1 and ABCG1...
  78. pmc Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion
    Liqing Yu
    McDermott Center for Human Growth and Development and Departments of Molecular Genetics and Biochemistry, The Howard Hughes Medical Institute and Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:16237-42. 2002
    b>Cholesterol and other sterols exit the body primarily by secretion into bile...
  79. pmc Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
    Mireille Ouimet
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Cell Metab 13:655-67. 2011
    The lipid droplet (LD) is the major site of cholesterol storage in macrophage foam cells and is a potential therapeutic target for the treatment of atherosclerosis...
  80. pmc Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation
    Isabelle Gerin
    Laboratory for Physiological Chemistry, de Duve Institute, Universite Catholique de Louvain, 1200 Bruxelles, Belgium
    J Biol Chem 285:33652-61. 2010
    ..activated in situations of reduced lipid abundance and activates numerous genes involved in cholesterol, fatty acid, and phospholipid synthesis...
  81. pmc Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    Robert E Lanford
    Department of Virology and Immunology and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78227, USA
    Science 327:198-201. 2010
    ..The prolonged virological response to SPC3649 treatment without HCV rebound holds promise of a new antiviral therapy with a high barrier to resistance...
  82. pmc Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
    Kristiina Rajamäki
    Wihuri Research Institute, Helsinki, Finland
    PLoS ONE 5:e11765. 2010
    ..As cholesterol crystals are abundant in atherosclerotic lesions, and IL-1beta has been linked to atherogenesis, we explored ..
  83. doi Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis
    S Matthijs Boekholdt
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    JAMA 307:1302-9. 2012
    The associations of low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and apolipoprotein B (apoB) levels with the risk of cardiovascular events among patients treated with statin therapy ..
  84. pmc Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARγ and LXRα pathways
    Giulia Chinetti-Gbaguidi
    Univ Lille Nord de France, Lille, France
    Circ Res 108:985-95. 2011
    ..Macrophages are heterogeneous cells that adapt their response to environmental cytokines. Th1 cytokines promote monocyte differentiation into M1 macrophages, whereas Th2 cytokines trigger an "alternative" M2 phenotype...
  85. pmc Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
    H Shimano
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 100:2115-24. 1997
    The synthesis of cholesterol and its uptake from plasma LDL are regulated by two membrane-bound transcription factors, designated sterol regulatory element binding protein-1 and -2 (SREBP-1 and SREBP-2)...
  86. doi Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
    Carlos G Leon
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Prostate 70:390-400. 2010
    ..Increased expression of several enzymes responsible for cholesterol synthesis and conversion into downstream androgens has been documented in human CRPC tumors in comparison to ..
  87. pmc Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
    Galina Polekhina
    Biota Structural Biology Laboratory, St Vincent s Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Proc Natl Acad Sci U S A 102:600-5. 2005
    The cholesterol-dependent cytolysins (CDCs), a superfamily of pore-forming toxins, are characterized by a conserved undecapeptide motif that is believed to be critical for membrane recognition by means of cholesterol...
  88. doi Sterol metabolism and SREBP activation
    Ryuichiro Sato
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Arch Biochem Biophys 501:177-81. 2010
    b>Cholesterol is one of the major components of membrane lipids. Adjustment of the membrane cholesterol balance is, therefore, pivotal in the maintenance of cellular homeostasis...
  89. pmc Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
    Michael S Brown
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Lipid Res 50:S15-27. 2009
    b>Cholesterol biosynthesis is among the most intensely regulated processes in biology. Synthetic rates vary over hundreds of fold depending on the availability of an external source of cholesterol...
  90. pmc Niemann-Pick disease type C
    Marie T Vanier
    Institut National de la Sante et de la Recherche Medicale, Unité 820, Faculté de Médecine Lyon Est Claude Bernard, 7 Rue G, Paradin, F 69008, Lyon, France
    Orphanet J Rare Dis 5:16. 2010
    ..The exact functions of the NPC1 and NPC2 proteins are still unclear. NP-C is currently described as a cellular cholesterol trafficking defect but in the brain, the prominently stored lipids are gangliosides...
  91. ncbi Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
    Rod Jackson
    Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Lancet 365:434-41. 2005
    In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels...
  92. pmc Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival
    Mingqun Lin
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    Infect Immun 71:5324-31. 2003
    ..Membrane incorporation of cholesterol from the eukaryotic host is known to be essential for other fragile and pleomorphic bacteria and mycoplasmas ..
  93. ncbi Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
    John M Dietschy
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75390 8887, USA
    J Lipid Res 45:1375-97. 2004
    Unesterified cholesterol is an essential structural component of the plasma membrane of every cell...
  94. doi How much does HDL cholesterol add to risk estimation? A report from the SCORE Investigators
    Marie Therese Cooney
    Department of Cardiology Adelaide Meath Hospital, Tallaght, Dublin 24, Ireland
    Eur J Cardiovasc Prev Rehabil 16:304-14. 2009
    ..mortality based on age, sex, country of origin, systolic blood pressure, smoking status and either total cholesterol (TC) or TC/high-density lipoprotein cholesterol (HDL-C) ratio...
  95. pmc Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    Jay D Horton
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 100:12027-32. 2003
    The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2...
  96. ncbi Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential
    Richard G Lee
    Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circ Res 95:998-1004. 2004
    ..CEs) to apoB-containing lipoproteins, whereas LCAT is an antiatherogenic enzyme that facilitates reverse cholesterol transport by esterifying free cholesterol on HDL particles...
  97. pmc High-density lipoprotein function, dysfunction, and reverse cholesterol transport
    Edward A Fisher
    Department of Cardiovascular Medicine, New York University School of Medicine, New York, NY 444195, USA
    Arterioscler Thromb Vasc Biol 32:2813-20. 2012
    Although high high-density lipoprotein (HDL)-cholesterol levels are associated with decreased cardiovascular risk in epidemiological studies, recent genetic and pharmacological findings have raised doubts about the beneficial effects of ..
  98. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
    ..We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease...
  99. pmc Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2070-5. 2004
    ..We report alterations in sphingolipid and cholesterol metabolism during normal brain aging and in the brains of AD patients that result in accumulation of long-chain ..
  100. doi Cellular cholesterol trafficking and compartmentalization
    Elina Ikonen
    Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, University of Helsinki, Helsinki FI 00014, Finland
    Nat Rev Mol Cell Biol 9:125-38. 2008
    b>Cholesterol is an essential structural component in the cell membranes of most vertebrates...

Research Grants70

  1. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..A blood sample may be obtained to test for cholesterol level and genes related to inflammation...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..A blood sample may be obtained to test for cholesterol level and genes related to inflammation...
  3. Mice Humanized with Hepatocytes and iPS Cells from Patients with Metabolic Diseas
    Stephen C Strom; Fiscal Year: 2010
    ..compounds such as drugs or toxins as well as endogenous compounds like hormones, bilirubin and bile acids and cholesterol. Liver-based metabolic disease can result from mutations in genes in these critical pathways...
  4. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..adiposity, branched chain amino acids (BCAAs), free fatty acids (FFAs), ketone bodies, triacylglcyerols (TAG), cholesterol, blood pH, and markers of inflammation and oxidative stress in mice fed a high saturated fat diet;(b) determine ..
  5. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..upon recent evidence, we propose that membrane proteins are concentrated in "protein islands," protein and cholesterol-rich domains separated by expanses of mostly lipid...
  6. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..The candidate previously identified the reverse cholesterol transport (RCT) system as a potential mediator of functional regression and ultimately luteolysis (complete ..
  7. Cardiotrophin-Like Cytokine 1, a Candidate Molecule for the FSGS Factor
    Virginia J Savin; Fiscal Year: 2010
    ..of large amounts of protein in the urine, edema or swelling of tissues, low plasma proteins and increased cholesterol is termed nephrotic syndrome...
  8. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..ratio, homeostasis model assessment of insulin resistance (HOMA-IR), fasting triglyceride levels, total cholesterol, LDL cholesterol, and HDL cholesterol...
  9. T cell regulation by N-glycosylation
    Michael Demetriou; Fiscal Year: 2013
    ..recruitment of Nck, WASp, SLP-76 and CD4-Lck to TCR, F-actin remodeling and transfer of the complex to GM1/cholesterol-enriched microdomains (GEMs)...
  10. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..Metsyn will be defined by National Cholesterol Education Program criteria, using measures of waist girth and/or BMI, blood pressure, and fasting glucose, ..
  11. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..CAD risk factors include high blood pressure, high cholesterol and diabetes. These risk factors are often associated with one another and referred to as metabolic syndrome...
  12. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..The second strategy is the administration of a common anti-cholesterol drug known as lovastatin. This too had similar effects as vaccination...
  13. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..be desirable to develop a test that will identify the biological markers of Alzheimer's disease, much like cholesterol now serving as a biomarker of heart disease...
  14. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..In addition, the amount and type of fat in the diet can regulate the levels of serum cholesterol and triglycerides, risk factors for atherosclerosis...
  15. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..It is clear that chemical change of low density lipoprotein (LDL), which contains "bad cholesterol," is one of the major reasons causing the blood vessels to become harden...
  16. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..risk factors (including waist circumference, systolic blood pressure, fasting triglycerides, fasting HDL cholesterol, fasting plasma glucose, fasting plasma insulin, adiponectin concentrations and insulin resistance indices such ..
  17. Tissue-specific delivery of probes by control of membrane trafficking of endoprot
    Blake Peterson; Fiscal Year: 2010
    ..These unique biological activities result from functional mimicry of free cholesterol, a key component of plasma and endosomal membranes...
  18. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    ..Moreover, increasing numbers of prescription drugs such as cholesterol-lowering drugs and over-the-counter medications, including acetaminophen, can potentially cause liver toxicity ..
  19. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..The CE-rich LDs in the adrenal and ovary serve as important sources of cholesterol substrate for steroid hormone production...
  20. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..collected, frozen, and stored for all participants, and vitamin E, beta-carotene, retinol, and total and HDL cholesterol were determined...
  21. Roles for microRNA-122 in hepatitis C virus RNA amplification
    Peter Sarnow; Fiscal Year: 2013
    ..This application proposes to study the roles for miR-122 in the viral life cycle and in cholesterol biosynthesis using a novel class of antisense molecules, locked nucleic acids (LNAs) that can easily be ..
  22. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..which fitness adaptation exerts an effect on neurocognition -- Notably, low levels of high-density lipoprotein cholesterol (HDL-C), elevated inflammation (C-reactive protein (CRP) and interleukins (IL-1A)), deranged glucose ..
  23. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..inflammatory cells (macrophages and T cells), expansion of vascular smooth muscle cells (vSMCs) and buildup of cholesterol and extracellular matrix within the inner lining of arteries...
  24. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..These MUFA serve as precursors for the synthesis of hepatic lipids (triglycerides (TG) and cholesterol esters (CE) and thus play a role in the development of hepatic steatosis...
  25. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..Biomarker measures studied include C-reactive protein, white blood count, albumin, uric acid, creatinine, serum cholesterol, glycosylated hemoglobin, dehydroepiandrosterone sulfate (DHEAS &DHEA), fasting glucose and insulin ..
  26. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..This includes virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids...
  27. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..binding protein (SREBP) transcription factors have been identified as key regulators of genes involved in both cholesterol and lipid homeostasis...
  28. A2b Adenosine Receptor Regulation of Metabolic Disease and Inflammation
    Anna Eisenstein; Fiscal Year: 2013
    ..Furthermore, administration of a high fat, high cholesterol diet (HFD) vastly upregulates the expression of the A2b adenosine receptor (A2bAR), and A2bAR KO mice subjected ..
  29. Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
    THOMAS JAY EBERT; Fiscal Year: 2013
    ..or 3-hydroxy-3-methyl-glutaryl- coenzyme A reductase inhibitors, that are used routinely to lower blood cholesterol levels, modulate I/R injury in a dose related manner;and 4) statins reduce hyperglycemia inhibition of APC, and ..
  30. Biochemical Characterization of Cytochrome b5 Reductase in Candida albicans
    MARY JOLENE PATRICIA HOLLOWAY; Fiscal Year: 2010
    ..cb5r), has a high pharmacological significance owing to its role in fatty acid elongation, ergosterol (or cholesterol in mammals) biosynthesis, and cytochrome P450-mediated detoxification of xenobiotics...
  31. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
  32. Mechanistic Studies on Prostate Cancer Prevention by Gugulipid
    Dong Xiao; Fiscal Year: 2013
    ..GL has been used in many clinical trials that have focused on its cholesterol-lowering effect and the products of standardized formulations of Commiphora mukul are already in human use in U...
  33. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..baseline predict changes in fasting glucose, A1C and insulin resistance, in lipids (serum triglycerides, total cholesterol, LDLc, HDLc, nonHDLc, and oxidized LDL), and in total fat mass and bone density measured by dual x-ray ..
  34. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..Ossabaw swine fed a normal maintenance diet (7% kcal from fat) or an atherogenic diet (45% kcal from fat and 2% cholesterol) for 20 weeks...
  35. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ..lipid secretion is a tightly regulated process requiring synthesis, assembly and transport of triglyceride and cholesterol ester containing droplets (cytoplasmic lipid droplets -CLD) to the apical membrane of mammary epithelial cells ..
  36. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..e. its effect on cholesterol homeostasis in the central nervous system...
  37. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial obstruction, ..
  38. The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver Disease
    KATHLEEN ELIZABETH COREY; Fiscal Year: 2013
    ..of a two lipid biomarkers, oxidized low density lipoproteins (OxLDL) and non-high density lipoprotein cholesterol for NAFLD...
  39. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..particular, nonalcoholic fatty liver disease (NAFLD) is a disorder of hepatic lipid homeostasis in which both cholesterol and triglycerides accumulate in hepatocytes...
  40. Chemical Biology Studies of 3-Iodothyronamine and Related Thyroid Hormone Metabol
    THOMAS STERLING SCANLAN; Fiscal Year: 2013
    ..lipoprotein of low density lipoprotein (LDL) particles, suggesting a potential role of T1AM in modulating cholesterol homeostasis. T1AM has very unusual pharmacokinetic properties for a biogenic primary phenethylamine...
  41. A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
    Steven Kawut; Fiscal Year: 2009
    ..Simvastatin decreases cholesterol, stabilizes the endothelial cell layer, increases the bioavailability of nitric oxide, reduces oxidative stress,..
  42. Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD Risk
    Christopher D Gardner; Fiscal Year: 2010
    ..Secondary outcomes include blood pressure, blood cholesterol, fasting insulin, serum isoprostanes (a measure of oxidative stress) and s-nitrosyl glutathione (a stable, ..
  43. Impact of Diabetes and Hyperlipidemia on Host Defense
    Hardy Kornfeld; Fiscal Year: 2013
    ..We now plan testing whether combined high glucose and high cholesterol or triglyceride synergistically weaken TB defense...
  44. MECHANISMS OF FGF RECEPTOR REGULATION AND SIGNALING
    Moosa Mohammadi; Fiscal Year: 2013
    ..FGF19 subfamily acts in an endocrine fashion to regulate major metabolic processes including glucose, lipid, cholesterol, and bile acid metabolism, and phosphate/vitamin D homeostasis...
  45. Epistasis in Steroidogenic Genes in the Prediction of Alzheimer's Disease
    CRAIG STEPHEN ATWOOD; Fiscal Year: 2013
    ..the major risk factor for AD, and ABCA7, recently associated with AD from GWAS, alter the neuronal transport of cholesterol, the precursor from which all sex steroids are synthesized...
  46. Exploring persistent epigenetic changes after prenatal famine exposure in humans
    L H Lumey; Fiscal Year: 2010
    ..are related to disease risk factors for cardio-vascular disease and diabetes such as obesity, elevated blood cholesterol or fasting glucose values...
  47. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..Oxidation changes "good cholesterol" into "bad cholesterol," which can no longer clean up blood vessels and airways...
  48. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2013
    ..resistin, IL-6, and TNF-alpha);circulating and tissue levels of free fatty acids, triglyceride and cholesterol;and fat cell size distribution in mesenteric and subcutaneous fat tissue...
  49. NPC1L1 and Metabolic Diseases
    Liqing Yu; Fiscal Year: 2013
    ..by applicant): Niemann-Pick C1-Like 1 (NPC1L1) was originally identified as an essential protein for intestinal cholesterol absorption...
  50. Dietary Cholesterol and Defects in Cholesterol Synthesis
    ROBERT DAVID STEINER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We propose a study of cholesterol metabolism and the effects of cholesterol deficiency in Smith-Lemli-Opitz Syndrome (SLOS)...
  51. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..Study (WHS) participants and conduct a detailed, prospective cohort evaluation of standard lipid markers (total cholesterol, low-density lipoprotein cholesterol (LDL-C), HDL-C, triglycerides), and novel lipid markers (apolipoprotein A-..
  52. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial obstruction, ..
  53. StAR expression: Integration of Transcription with regulation via the mRNA 3'UTR
    COLIN ROBERT JEFCOATE; Fiscal Year: 2012
    ..ACTH stimulation of cortisol synthesis starts with the conversion of cholesterol to pregnenolone by mitochondrial cytochrome P450 11A1...
  54. Diet Quality and CVD Risk Factors in a Family Based Weight Management Study
    Alice H Lichtenstein; Fiscal Year: 2013
    ..Measuring the CVD risk factors (total, HDL and LDL cholesterol, triglyceride, hsCRP, glucose and insulin concentrations, blood pressure and waist circumference) in the ..
  55. CELLULAR REGULATION OF CLATHRIN ASSEMBLY AND FUNCTION
    Frances M Brodsky; Fiscal Year: 2013
    ..These include nutrient and cholesterol uptake, glucose transporter and insulin targeting, immune receptor traffic during antigen presentation and ..
  56. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..the role of certain ion channels (TRPC channels) that when eliminated abolish the inhibitory effect of high cholesterol in a mouse model...
  57. Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Clavia Ruth Wooton-Kee; Fiscal Year: 2011
    ..have decreased expression of genes involved in several metabolic pathways, including bile acid synthesis (cholesterol 71-hydroxylase (Cyp7a1)), cholesterol synthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase)),..
  58. Hepatic Lipase and HCV Infection
    Tianyi Wang; Fiscal Year: 2010
    ..Interestingly, recent studies have linked host cholesterol and fatty acid metabolic pathways to HCV life cycle...
  59. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..steroids: Cort, Mifepristone (a GR receptor antagonist), eplerenone (an MR receptor antagonist) and/or cholesterol. The secretion of endogenous Cort will be stimulated by stress...
  60. Lipoprotein Structure and Function by Individual Particle Electron Tomography
    Gang Ren; Fiscal Year: 2013
    ..HDL, LDL, IDL and VLDL respectively), as well as chylomicrons;HDL and LDL are major players in plasma cholesterol metabolism...
  61. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..CES1 has been shown to liberate free cholesterol from neutral lipid droplets in macrophages and in the last funding cycle we showed that this function can be ..
  62. New pathways regulating bile acid homeostasis and cholestatic liver diseases
    Li Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The conversion to bile acids represents a major pathway for cholesterol elimination from the body, which is therefore of critical importance in maintaining cholesterol homeostasis...
  63. Over-Expression of microRNA-126 in Macrophages for Treatment of Atherosclerosis
    Suzette Laing; Fiscal Year: 2013
    ..The continued monocyte recruitment and cholesterol accumulation in the vessel wall facilitates chronic disease progression...
  64. Beauveriolide-Derived Cyclodepsipeptides as a New Class of Anti-Alzheimer's Drugs
    Paul Wentworth; Fiscal Year: 2010
    ..It has been shown definitively that the generation and clearance of A2 in the CNS is regulated by cholesterol homeostasis...
  65. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2006
    The objective of this application is to investigate the predictive value of using measures of cholesterol homeostasis to identify individuals at high risk of developing cardiovascular disease (CVD) relative to established risk factors...
  66. Amyloid Beta-Protein: ApoE and Cholesterol Homeostasis
    WELLINGTON WOOD; Fiscal Year: 2009
    This application focuses on mechanisms of amyloid beta-protein perturbation of cholesterol and apoE homeostasis within astrocytes and resulting consequences on neuronal function...
  67. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The dominant underlying factor for this disease includes elevated plasma low density lipoprotein (LDL)-cholesterol levels in association with hypertriglyceridemia, abdominal obesity, or insulin resistance...
  68. Novel Modulators of LDL Metabolism
    Nabil Elshourbagy; Fiscal Year: 2009
    ..A high cholesterol level is a well-known risk factor for heart disease...
  69. Cholesterol Uptake by Cryptosporidium
    Isabelle Coppens; Fiscal Year: 2010
    ..We demonstrated that Cryptosporidium developing in enterocytes contains significant amounts of cholesterol though it lacks the genes for cholesterol biosynthesis and modification...
  70. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    Gallbladder epithelial cells and cholangiocytes are exposed to high concentrations of cholesterol because the major pathway of cholesterol excretion from the body is through bile...