calcitriol

Summary

Summary: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

Top Publications

  1. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
  2. ncbi Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
  3. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
  4. ncbi Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    Orlando Gutierrez
    Department of Medicine Internal Medicine Residency Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Am Soc Nephrol 16:2205-15. 2005
  5. pmc VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression
    Mark B Meyer
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 26:37-51. 2012
  6. pmc No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial
    Carla Bizzarri
    Department of Endocrinology and Diabetes, Bambino Gesu Children s Hospital, Rome, Italy
    Diabetes Care 33:1962-3. 2010
  7. ncbi Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts
    Evelyne van Etten
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:93-101. 2005
  8. ncbi 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells
    A Boonstra
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 167:4974-80. 2001
  9. ncbi Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA
    FASEB J 19:1067-77. 2005
  10. ncbi Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns
    Kambis Sadeghi
    Surgical Research Laboratories, Medical University of Vienna, A 1090 Vienna, Austria
    Eur J Immunol 36:361-70. 2006

Detail Information

Publications338 found, 100 shown here

  1. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
    ..This overview provides a brief description of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D. It also provides information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy...
  2. ncbi Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
    ..Paricalcitol, a new vitamin D analogue, appears to lessen the elevations in serum calcium and phosphorus levels, as compared with calcitriol, the standard form of injectable vitamin D.
  3. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  4. ncbi Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease
    Orlando Gutierrez
    Department of Medicine Internal Medicine Residency Training Program, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    J Am Soc Nephrol 16:2205-15. 2005
    Hyperphosphatemia, calcitriol deficiency, and secondary hyperparathyroidism (SHPT) are common complications of chronic kidney disease (CKD)...
  5. pmc VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression
    Mark B Meyer
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 26:37-51. 2012
    ..These data reveal additional complexity in the regulation of target genes by 1,25-(OH)(2)D(3) and support a direct action of both VDR and the TCF4/β-catenin regulatory complex at c-FOS and c-MYC...
  6. pmc No protective effect of calcitriol on beta-cell function in recent-onset type 1 diabetes: the IMDIAB XIII trial
    Carla Bizzarri
    Department of Endocrinology and Diabetes, Bambino Gesu Children s Hospital, Rome, Italy
    Diabetes Care 33:1962-3. 2010
    We investigated whether supplementation of the active form of vitamin D (calcitriol) in recent-onset type 1 diabetes can protect beta-cell function evaluated by C-peptide and improve glycemic control assessed by A1C and insulin requirement...
  7. ncbi Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts
    Evelyne van Etten
    Laboratory of Experimental Medicine and Endocrinology LEGENDO, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    J Steroid Biochem Mol Biol 97:93-101. 2005
    ....
  8. ncbi 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells
    A Boonstra
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304, USA
    J Immunol 167:4974-80. 2001
    ....
  9. ncbi Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA
    FASEB J 19:1067-77. 2005
    ..Our findings reveal a novel activity of 1,25-dihydroxyvitamin D3 and the VDR in regulation of primate innate immunity...
  10. ncbi Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns
    Kambis Sadeghi
    Surgical Research Laboratories, Medical University of Vienna, A 1090 Vienna, Austria
    Eur J Immunol 36:361-70. 2006
    ..Our data provide strong evidence that 1,25(OH)(2)D3 primes monocytes to respond less effectively to bacterial cell wall components in a VDR-dependent mechanism, most likely due to decreased levels of TLR2 and TLR4...
  11. ncbi Minireview: vitamin D receptor: new assignments for an already busy receptor
    Anthony W Norman
    Department of Biochemistry and Biomedical Sciences, University of California, Riverside, California 92506, USA
    Endocrinology 147:5542-8. 2006
    ....
  12. pmc Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling
    H G Pálmer
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, E 28029 Madrid, Spain
    J Cell Biol 154:369-87. 2001
    ..Our results show that 1alpha,25(OH)2D(3) induces E-cadherin and modulates beta-catenin-TCF-4 target genes in a manner opposite to that of beta-catenin, promoting the differentiation of colon carcinoma cells...
  13. ncbi Randomized, open-label phase III trial of docetaxel plus high-dose calcitriol versus docetaxel plus prednisone for patients with castration-resistant prostate cancer
    Howard I Scher
    Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 29:2191-8. 2011
    To compare the efficacy and safety of docetaxel plus high-dose calcitriol (DN-101) to docetaxel plus prednisone in an open-label phase III trial.
  14. ncbi Reversibility of calcitriol-induced medial artery calcification in rats with intact renal function
    Alicia Bas
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    J Bone Miner Res 21:484-90. 2006
    ..Induction and regression of calcitriol-induced VC was studied in 47 rats...
  15. pmc Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response
    Jun Tang
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:4624-32. 2009
    ..Oral calcitriol (1,25-dihydroxyvitamin D(3)) prevented as well as partly reversed disease and suppressed immunological responses...
  16. pmc Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo
    M D Griffin
    Department of Internal Medicine, Division of Nephrology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 98:6800-5. 2001
    ..We conclude that 1alpha,25(OH)(2)D(3)/VDR mediates physiologically relevant inhibition of DC maturity that is resistant to maturational stimuli and modulates antigen-specific immune responses in vivo...
  17. ncbi Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system
    Hiroshi Tsujikawa
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Mol Endocrinol 17:2393-403. 2003
    ..These observations suggest that klotho may participate in a negative regulatory circuit of the vitamin D endocrine system, through the regulation of 1alpha-hydroxylase gene expression...
  18. ncbi Mortality risk among hemodialysis patients receiving different vitamin D analogs
    F Tentori
    Dialysis Clinic Inc, Albuquerque, New Mexico, USA
    Kidney Int 70:1858-65. 2006
    ..In for-profit dialysis clinics, mortality was higher for patients on calcitriol compared to paricalcitol. Doxercalciferol, a second vitamin D2 analog, is currently available...
  19. ncbi Circulating calcitriol concentrations and total mortality
    Armin Zittermann
    Department of Cardio Thoracic Surgery, Heart Center North Rhine Westfalia, Ruhr University Bochum, Bad Oeynhausen, Germany
    Clin Chem 55:1163-70. 2009
    ..Little is known, however, about the effect of low concentrations of the vitamin D hormone calcitriol on total mortality...
  20. pmc Chondro/osteoblastic and cardiovascular gene modulation in human artery smooth muscle cells that calcify in the presence of phosphate and calcitriol or paricalcitol
    V Shalhoub
    Department of Metabolic Disorders, Amgen, Inc, Thousand Oaks, California, USA
    J Cell Biochem 111:911-21. 2010
    ..Cultured CASMCs were exposed to phosphate-containing differentiation medium (DM) with and without calcitriol, paricalcitol, or the calcimimetic R-568 (10(-11)-10(-7) M) for 7 days...
  21. ncbi Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Biochem Pharmacol 72:332-43. 2006
    ....
  22. ncbi Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3
    Jürgen Schauber
    Division of Dermatology, University of California, San Diego and VA San Diego Healthcare System, San Diego, California, USA
    J Invest Dermatol 128:816-24. 2008
    ....
  23. ncbi Intravenous calcitriol therapy increases serum concentrations of fibroblast growth factor-23 in dialysis patients with secondary hyperparathyroidism
    Hiroshi Nishi
    Division of Nephrology and Dialysis Center, Kobe University School of Medicine, Kobe, Japan
    Nephron Clin Pract 101:c94-9. 2005
    ..Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy.
  24. ncbi Oral calcitriol for reduction of proteinuria in patients with IgA nephropathy: a randomized controlled trial
    Li Jun Liu
    Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, PR China
    Am J Kidney Dis 59:67-74. 2012
    Vitamin D has shown efficacy in the reduction of proteinuria in patients with chronic kidney disease. This study aimed to determine the effect of calcitriol on urinary protein excretion in patients with immunoglobulin A (IgA) nephropathy.
  25. ncbi Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients
    Mohammad Hassan Eftekhari
    Nutrition Department, Research Center for Health Sciences, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz I R Iran
    Asia Pac J Clin Nutr 20:521-6. 2011
    ..Type 2 diabetes is a major public health problem. Recent epidemiological evidence also points to a potential association of vitamin D insufficiency with adverse metabolic risks, including that for type 2 diabetes...
  26. pmc Association of oral calcitriol with improved survival in nondialyzed CKD
    Abigail B Shoben
    Department of Biostatistics, Puget Sound Veterans Affairs Medical Center, Seattle, WA, USA
    J Am Soc Nephrol 19:1613-9. 2008
    ..We evaluated associations of oral calcitriol use with mortality and dialysis dependence in 1418 nondialysis patients with CKD and hyperparathyroidism in the ..
  27. ncbi Oral calcitriol for the treatment of persistent proteinuria in immunoglobulin A nephropathy: an uncontrolled trial
    Cheuk Chun Szeto
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Am J Kidney Dis 51:724-31. 2008
    ..We conducted an open-label study to evaluate the antiproteinuric effect of calcitriol on proteinuria in patients with immunoglobulin A (IgA) nephropathy.
  28. pmc No effect of the 1alpha,25-dihydroxyvitamin D3 on beta-cell residual function and insulin requirement in adults with new-onset type 1 diabetes
    Markus Walter
    Diabetes Research Institute, Forschergruppe Diabetes eV, Munich, Germany
    Diabetes Care 33:1443-8. 2010
    ..To determine whether daily intake of 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] is safe and improves beta-cell function in patients with recently diagnosed type 1 diabetes...
  29. pmc Vitamin D receptor activators can protect against vascular calcification
    Suresh Mathew
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Am Soc Nephrol 19:1509-19. 2008
    ..In an effort to explain this discrepancy, we studied the effects of the VDR activators calcitriol and paricalcitol on aortic calcification in a mouse model of chronic kidney disease (CKD)-stimulated ..
  30. ncbi Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells
    Juan Kong
    Dept of Medicine, Univ of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 290:E916-24. 2006
    ....
  31. ncbi Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:1305-15. 2006
    ..The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D...
  32. ncbi Vitamin D3: a transcriptional modulator of the interferon-gamma gene
    M Cippitelli
    Laboratory of Pathophysiology, Regina Elena Cancer Institute, Rome, Italy
    Eur J Immunol 28:3017-30. 1998
    ..The overall data indicate that direct modulation of the IFN-gamma promoter activity is one of the possible mechanisms involved in the repressive effect of 1,25-(OH)2D3 on IFN-gamma gene expression...
  33. ncbi Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells
    Jacqueline Moreno
    Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Cancer Res 65:7917-25. 2005
    b>Calcitriol exhibits antiproliferative and pro-differentiation effects in prostate cancer. Our goal is to further define the mechanisms underlying these actions...
  34. pmc Tissue-selective regulation of aromatase expression by calcitriol: implications for breast cancer therapy
    Aruna V Krishnan
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305 5103, USA
    Endocrinology 151:32-42. 2010
    ..We show that calcitriol, the hormonally active form of vitamin D, regulates the expression of aromatase in a tissue-selective manner...
  35. ncbi Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo
    Hitoshi Saito
    Pharmaceutical Research Department II, Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412 8513, Japan
    J Biol Chem 280:2543-9. 2005
    ....
  36. pmc Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene
    D D'Ambrosio
    Roche Milano Ricerche, I 20132, Milan, Italy
    J Clin Invest 101:252-62. 1998
    ..Thus, 1,25(OH)2D3 may negatively regulate IL-12 production by downregulation of NF-kappaB activation and binding to the p40-kappaB sequence...
  37. pmc Cyclical chromatin looping and transcription factor association on the regulatory regions of the p21 (CDKN1A) gene in response to 1alpha,25-dihydroxyvitamin D3
    Anna Saramaki
    Department of Biosciences, University of Kuopio, FIN 70210 Kuopio, Finland
    J Biol Chem 284:8073-82. 2009
    ..In conclusion, 1alpha,25-dihydroxyvitamin D(3) regulates p21 transcription by inducing cyclical chromatin looping that depends on both histone deacetylation and demethylation...
  38. pmc Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD
    Jason R Stubbs
    3901 Rainbow Boulevard, MS 3002, Kansas City, KS 66160, USA
    J Am Soc Nephrol 21:353-61. 2010
    ..These data suggest that nutritional vitamin D therapy has a biologic effect on circulating monocytes and associated inflammatory markers in patients with ESRD...
  39. ncbi Differences in transcriptional effects of 1α,25 dihydroxyvitamin D3 on fibroblasts associated to breast carcinomas and from paired normal breast tissues
    Laura Tojeiro Campos
    Departamento de Radiologia e Oncologia, Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Arnaldo, 455, Sala 4112, CEP 01246 903, Sao Paulo, SP, Brazil
    J Steroid Biochem Mol Biol 133:12-24. 2013
    ..Co-expression network and interactome analysis of genes commonly regulated by 1,25D in NAFs and CAFs revealed differences in their co-expression values, suggesting that 1,25D effects in NAFs are distinct from those triggered in CAFs...
  40. pmc Vitamin D receptor as a master regulator of the c-MYC/MXD1 network
    Reyhaneh Salehi-Tabar
    Department of Medicine, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 109:18827-32. 2012
    ..Thus, 1,25D and the VDR regulate the c-MYC/MXD1 network to suppress c-MYC function, providing a molecular basis for cancer preventive actions of vitamin D...
  41. ncbi Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D
    Reinhold G Erben
    Institute of Animal Physiology, Ludwig Maximilians University, 80539 Munich, Germany
    Mol Endocrinol 16:1524-37. 2002
    ..Furthermore, rapid, nongenomic responses to 1,25-(OH)(2)D(3) in osteoblasts were abrogated in homozygous mice, supporting the conclusion that the classical VDR mediates the nongenomic actions of 1,25-(OH)(2)D(3)...
  42. ncbi Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes
    A Ravid
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva 49100, Israel
    J Endocrinol 173:525-32. 2002
    ....
  43. ncbi Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts
    Lorenza Díaz
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico, D F, Mexico
    J Reprod Immunol 81:17-24. 2009
    ..Since trophoblasts produce calcitriol, a hormone with strong immunosuppressive properties, we assessed the effects of this secosteroid on inflammatory ..
  44. ncbi The impact of 1,25(OH)2D3 and its structural analogs on gene expression in cancer cells--a microarray approach
    Carsten Kriebitzsch
    Laboratorium voor Experimentele Geneeskunde en Endocrinologie LEGENDO, Catholic University of Leuven, Belgium
    Anticancer Res 29:3471-83. 2009
    ....
  45. ncbi Molecular cloning of complementary DNA encoding the avian receptor for vitamin D
    D P McDonnell
    Science 235:1214-7. 1987
    ..This cDNA represents perhaps the rarest mRNA cloned to date in eukaryotes, as well as the first receptor sequence described for an authentic vitamin...
  46. ncbi 25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Circulation 111:1666-71. 2005
    ..We therefore tested the possibility that VSMCs possess an endogenous 25-hydroxyvitamin D3-1alpha-hydroxylase system, the final enzyme in the biosynthetic pathway of 1,25(OH)2D3...
  47. pmc Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: importance of mammary CYP27B1 for treatment and prevention
    Aruna V Krishnan
    Division of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States
    J Steroid Biochem Mol Biol 136:289-95. 2013
    b>Calcitriol [1,25(OH)2D3], the hormonally active form of vitamin D exerts anti-proliferative, pro-apoptotic, anti-inflammatory effects and other anticancer actions in breast cancer (BCa) cell cultures and animal models of BCa...
  48. pmc Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor
    I Alroy
    Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Cell Biol 15:5789-99. 1995
    ..This direct inhibition by a nuclear hormone receptor of transcriptional activators of the IL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents...
  49. pmc Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer
    Srilatha Swami
    Department of Medicine Endocrinology, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Endocrinology 153:2576-87. 2012
    1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3) or calcitriol], the hormonally active vitamin D metabolite, exhibits anticancer actions in models of breast cancer and prostate cancer...
  50. ncbi Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts
    G P Thomas
    Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia
    J Endocrinol 170:451-60. 2001
    ....
  51. ncbi Calcium and 1,25-dihydroxyvitamin D3 regulation of adipokine expression
    Xiaocun Sun
    Department of Nutrition, University of Tennessee, Knoxville, TN 37996 1900, USA
    Obesity (Silver Spring) 15:340-8. 2007
    ..However, whether the anti-obesity effect of dietary calcium plays a role in regulation of obesity-associated inflammation is not clear...
  52. ncbi 1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells
    Moshe Ben-Shoshan
    Department of Pediatrics, Dana Children s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mol Cancer Ther 6:1433-9. 2007
    ....
  53. ncbi Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients
    Maria Martinesi
    Department of Biochemical Sciences, University of Florence, Florence, Italy
    Inflamm Bowel Dis 14:597-604. 2008
    ..Our aim was to verify whether 2 vitamin D derivatives, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and EB 1089, could induce cell apoptosis and affect cell-cell interaction by regulating adhesion molecule levels...
  54. ncbi Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine
    Wayne A Cass
    Department of Anatomy and Neurobiology, MN 225 Chandler Medical Center, University of KY, Lexington, KY 40536 0298, USA
    Ann N Y Acad Sci 1074:261-71. 2006
    ..b>Calcitriol, the active metabolite of vitamin D, has potent effects on brain cells, both in vitro and in vivo, including the ..
  55. ncbi Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory
    Annapaula Giulietti
    Laboratory of Experimental Medicine and Endocrinology, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    Diabetes Res Clin Pract 77:47-57. 2007
    ..From these data we concluded that monocytes from type 2 diabetic patients have a pro-inflammatory profile. In addition, 1,25-dihydroxyvitamin D(3) was able to modulate inflammation in these monocytes...
  56. pmc Minireview: Vitamin D: is there a role in extraskeletal health?
    Sylvia Christakos
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue E609, Newark, New Jersey 07103, USA
    Endocrinology 152:2930-6. 2011
    ..In this review, we will summarize what is known and indicate the questions that remain and need to be addressed...
  57. ncbi Protective role of 1 alpha, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells
    Bo Ying Bao
    Department of Urology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Int J Cancer 122:2699-706. 2008
    ..The antioxidative effect of vitamin D strengthens its roles in cancer chemoprevention and adds to a growing list of beneficial effects of vitamin D against cancer...
  58. ncbi Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog
    Rachamallu Aparna
    Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    J Cell Biochem 104:1832-42. 2008
    ..In summary, our results indicate that 1alpha,25(OH)2-16-ene-23-yne-D3, a less calcemic vitamin D analog, exhibits potent anti-inflammatory effects and is a selective COX-2 inhibitor...
  59. ncbi Calcitriol blunts the deleterious impact of advanced glycation end products on endothelial cells
    Yeela Talmor
    Renal Physiology Laboratory, Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba, Tchernichovsky 59, Kfar Saba 44281, Israel
    Am J Physiol Renal Physiol 294:F1059-64. 2008
    ..end products (AGEs), which are elevated in diabetic and uremic patients, may induce vascular dysfunctions, and calcitriol may improve the cardiovascular complications...
  60. ncbi Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice
    Luis E Becker
    Division of Nephrology, Ruperto Carola University, Heidelberg, Germany
    Am J Physiol Renal Physiol 300:F772-82. 2011
    ..To assess a potentially different spectrum of actions, we compared the effects of paricalcitol and calcitriol on remodeling and calcification of the aortic wall in sham-operated and UNX ApoE-/- mice on a diet with normal ..
  61. ncbi 22-Oxa-1alpha,25-dihydroxyvitamin D3 inhibits metastasis and angiogenesis in lung cancer
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, Japan
    Carcinogenesis 26:1044-54. 2005
    ..Our findings show that 22-oxa-1alpha,25-D(3) is beneficial for the prevention of metastasis in lung carcinoma...
  62. ncbi Calcitriol sensitizes colon cancer cells to H2O2-induced cytotoxicity while inhibiting caspase activation
    Ruth Koren
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    J Steroid Biochem Mol Biol 101:151-60. 2006
    The anti-cancer activity of calcitriol, the active metabolite of Vitamin D, in the colon is usually attributed to its anti-proliferative and pro-differentiative actions...
  63. pmc Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo
    Ivy Chung
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 69:967-75. 2009
    b>Calcitriol (1,25-dihydroxycholecalciferol), the major active form of vitamin D, is antiproliferative in tumor cells and tumor-derived endothelial cells (TDEC)...
  64. ncbi Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages
    M Di Rosa
    Department of Bio Medical Sciences, Division of Infectious Diseases, University of Catania, Catania, Italy
    Cell Immunol 280:36-43. 2012
    ....
  65. ncbi 1alpha,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes
    Yohan Bosse
    McGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada
    Physiol Genomics 29:161-8. 2007
    ..The most significant network of upregulated genes included genes involved in morphogenesis, cell growth, and survival as well as genes encoding structural proteins, which are potentially involved in airway remodeling...
  66. ncbi Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells
    Yingfang Song
    Department of Respiratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Respirology 12:486-94. 2007
    ..This study investigated the effect of 1,25-(OH)(2)D(3) on passively sensitized human bronchial (airway) smooth muscle cell (HASMC) proliferation and MMP-9 and ADAM33 expressions...
  67. ncbi Microarray analysis of 1,25(OH)₂D₃ regulated gene expression in human primary osteoblasts
    Paola Tarroni
    Axxam SpA, San Raffaele Biomedical Science Park, 20132 Milan, Italy
    J Cell Biochem 113:640-9. 2012
    ....
  68. ncbi 1,25-Dihydroxyvitamin D(3) increases striatal GDNF mRNA and protein expression in adult rats
    Begoña Sánchez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Spain
    Brain Res Mol Brain Res 108:143-6. 2002
    ..In the present study, using semiquantitative RT-PCR and Western blot, we have shown that 1,25(OH)(2)D(3) administration intraperitoneally, significantly increases GDNF mRNA and protein levels in the striatum of adult rats...
  69. ncbi Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study
    Xiaocun Sun
    University of Tennessee, Knoxville, Tenn 37996 1900, USA
    J Nutrigenet Nutrigenomics 1:30-48. 2008
    Dietary calcium inhibits adiposity, and a key underlying mechanism is suppression of calcitriol, which modulates Ca(2+) signaling and mitochondrial uncoupling in adipocytes...
  70. ncbi Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
    Klára Sochorová
    Institute of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, V Uvalu 84, 150 06 Prague, Czech Republic
    Clin Immunol 133:69-77. 2009
    ..In contrast to calcitriol, paricalcitol has a reduced effect on intestinal calcium resorption thus avoiding undesirable hypercalcemia...
  71. ncbi Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells
    Jana Fritsche
    Department of Hematology and Oncology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Blood 102:3314-6. 2003
    ..Terminal maturation renders DCs unresponsive to the effects of 1,25(OH)2D3, but those cells are able to suppress the differentiation of their own precursor cells in a paracrine way through the production of 1,25(OH)2D3...
  72. ncbi Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol
    Britta Diesel
    Institut fur Humangenetik, Theoretische Medizin, Universitat des Saarlandes, Saarbrucken, Germany
    Clin Cancer Res 11:5370-80. 2005
    ..A better understanding of the vitamin D(3) metabolism is required to evaluate its potential therapeutic value for cancers. Here, we set out to contribute to the understanding of vitamin D(3) metabolism in glioblastoma multiforme...
  73. pmc A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer
    Jae Young So
    Department of Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Mol Pharmacol 79:360-7. 2011
    ..The novel Gemini vitamin D analog, BXL0124, represses CD44 expression in MCF10DCIS.com cells in vitro and in xenograft tumors, suggesting an inhibitory role of a Gemini vitamin D derivative on breast cancer stem cells...
  74. pmc Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity
    Hong Jin Lee
    Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Cancer Prev Res (Phila) 1:476-84. 2008
    ..Our results suggest that Gemini vitamin D analogues may be potent agents for the prevention and treatment of both ER-positive and ER-negative breast cancer without hypercalcemia toxicity...
  75. pmc Cyclical regulation of the insulin-like growth factor binding protein 3 gene in response to 1alpha,25-dihydroxyvitamin D3
    Marjo Malinen
    Department of Biosciences, University of Eastern Finland, Kuopio, Finland
    Nucleic Acids Res 39:502-12. 2011
    ..In conclusion, 1α,25(OH)(2)D(3) regulates IGFBP3 transcription through short-term cyclical association of VDR, HDAC4 and HDAC6 to both VDRE-containing chromatin regions...
  76. pmc Molecular mechanism underlying 1,25-dihydroxyvitamin D regulation of nephrin gene expression
    Dilip K Deb
    Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 286:32011-7. 2011
    ..Nephrin up-regulation likely accounts for part of the renoprotective activity of vitamin D...
  77. ncbi Calcitriol inhibits Ether-à go-go potassium channel expression and cell proliferation in human breast cancer cells
    Rocío García-Becerra
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000 Mexico, DF, Mexico
    Exp Cell Res 316:433-42. 2010
    Antiproliferative actions of calcitriol have been shown to occur in many cell types; however, little is known regarding the molecular basis of this process in breast carcinoma...
  78. ncbi Antitumoral effects of calcitriol in basal cell carcinomas involve inhibition of hedgehog signaling and induction of vitamin D receptor signaling and differentiation
    Anja Uhmann
    Institute of Human Genetics, University of Goettingen, Heinrich Düker Weg 12, 37073 Goettingen, Germany
    Mol Cancer Ther 10:2179-88. 2011
    ..Here, we show that the application of the physiologically active form of vitamin D(3), calcitriol, inhibits proliferation and growth of BCC of Ptch mutant mice in vitro and in vivo...
  79. pmc Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations
    Erik A Imel
    Departments of Internal Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Endocrinol Metab 95:1846-50. 2010
    ..Treating XLH with phosphate and calcitriol may further increase FGF23 concentrations, based on in vitro and in vivo models.
  80. ncbi 1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression
    H Harant
    Novartis Research Institute, Vienna, Austria
    Eur J Biochem 250:63-71. 1997
    ..1alpha,25-Dihydroxyvitamin D3 (calcitriol) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50%, compared to 30% ..
  81. pmc Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1-34 versus calcitriol and calcium
    Karen K Winer
    the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 7510, USA
    J Clin Endocrinol Metab 95:2680-8. 2010
    ..This is the first randomized controlled study in children comparing treatment with synthetic human PTH 1-34 and calcitriol.
  82. ncbi Differential effects of vitamin D receptor activators on vascular calcification in uremic rats
    M Mizobuchi
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Kidney Int 72:709-15. 2007
    ..Uremic rats were given vehicle, calcitriol, paricalcitol, or doxercalciferol three times a week for 1 month...
  83. ncbi Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery
    S S Jensen
    Institute of Cancer Biology, The Danish Cancer Society, DK-2100 Copenhagen, Denmark
    Mol Endocrinol 15:1370-80. 2001
    ....
  84. ncbi Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer
    Srilatha Swami
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Nutr 137:205S-210S. 2007
    ..prostaglandin (PG) pathway as a novel target for the treatment of prostate cancer (PCa) using a combination of calcitriol and genistein, both of which have known antiproliferative properties...
  85. ncbi Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism
    Katherine Wesseling-Perry
    Division of Pediatric Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Kidney Int 79:112-9. 2011
    We compared the effects of calcitriol and doxercalciferol, in combination with either calcium carbonate or sevelamer, on bone, mineral, and fibroblast growth factor-23 (FGF-23) metabolism in patients with secondary hyperparathyroidism...
  86. ncbi 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
    J Steroid Biochem Mol Biol 118:162-70. 2010
    ..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties...
  87. ncbi 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis
    Christopher G Mayne
    Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53706, USA
    Eur J Immunol 41:822-32. 2011
    ..These data support a model wherein 1,25-(OH)(2) D(3) acts directly on pathogenic CD4(+) T cells to inhibit EAE...
  88. ncbi Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons
    L D Brewer
    Departments of Pharmacology and Internal Medicine, Division of Nephrology, Bone and Mineral Metabolism, College of Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 21:98-108. 2001
    ..Thus, these studies provide the first evidence of (1) direct neuroprotective actions of VDH at relatively low concentrations, and (2) selective downregulation of L-VSCC expression in brain neurons at the same, lower concentrations...
  89. ncbi 1,25-Dihydroxyvitamin D3 decreases podocyte loss and podocyte hypertrophy in the subtotally nephrectomized rat
    Alexander Kuhlmann
    Department of Pathology, Universitiy of Erlangen Nuremberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Am J Physiol Renal Physiol 286:F526-33. 2004
    ..This notion is suggested by less evidence of podocyte injury, decreased podocytes loss, and abrogation of podocyte hypertrophy, findings that may also explain less pronounced albuminuria and glomerulosclerosis...
  90. pmc 1,25-Dihydroxyvitamin D3 inhibits the differentiation and migration of T(H)17 cells to protect against experimental autoimmune encephalomyelitis
    Jae Hoon Chang
    Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
    PLoS ONE 5:e12925. 2010
    ..Vitamin D(3) ameliorates the onset of the experimental autoimmune encephalomyelitis (EAE); however, the direct effect of vitamin D(3) on T cells is largely unknown...
  91. ncbi Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells
    J Ruth Wu-Wong
    Abbott Laboratories, R4CM, AP52, 200 Abbott Park Rd, Abbott Park, IL 60064, USA
    Atherosclerosis 186:20-8. 2006
    ..1microM 1alpha,25-dihydroxyvitamin D3 (calcitriol) or paricalcitol (an analog of calcitriol) for 30 h. The effects of calcitriol and paricalcitol were similar...
  92. pmc Vitamin D and differentiation in cancer
    Elzbieta Gocek
    Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland
    Crit Rev Clin Lab Sci 46:190-209. 2009
    ..However, further studies are needed to fully understand the underlying mechanisms in order to improve the therapeutic approaches...
  93. ncbi Differential effects of paricalcitol and calcitriol on intestinal calcium absorption in hemodialysis patients
    Richard J Lund
    Department of Medicine, Creighton University, 3316 Dodge Street, Omaha, NE 68154, USA
    Am J Nephrol 31:165-70. 2010
    Increased parathyroid activity associated with chronic kidney disease is often managed with calcitriol, which can elevate serum calcium (Ca) by increasing bone resorption and intestinal absorption, whereas paricalcitol promotes less bone ..
  94. ncbi 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease
    M T Cantorna
    Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 130:2648-52. 2000
    ..1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD...
  95. pmc Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury
    Monica Froicu
    Department of Veterinary and Biomedical Sciences, Pathobiology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 8:5. 2007
    ..The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit development of inflammatory bowel disease (IBD) in IL-10 KO mice. Here, the role of the vitamin D receptor (VDR) and 1,25(OH)2D3 in acute experimental IBD was probed...
  96. ncbi Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    J Am Soc Nephrol 13:621-9. 2002
    ..The rapid induction of endothelial 1alpha-OHase activity by inflammatory cytokines suggests a novel autocrine/paracrine role for the enzyme, possibly as a modulator of endothelial cell adhesion...
  97. ncbi Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin
    S Nagpal
    Department of Biology, Allergan, Inc, Irvine, California 92713, U S A
    J Invest Dermatol 109:91-5. 1997
    ..Finally, we demonstrate that TIG2 is expressed at high levels in nonlesional psoriatic skin but at lower levels in the psoriatic lesion and that its expression is up-regulated in psoriatic lesions after topical application of tazarotene...
  98. pmc Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects
    S J Van Cromphaut
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, B 3000 Belgium
    Proc Natl Acad Sci U S A 98:13324-9. 2001
    ....
  99. ncbi Antiproliferative activity in vitro of side-chain analogues of calcitriol against various human normal and cancer cell lines
    A Opolski
    Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Anticancer Res 19:5217-22. 1999
    ..b>Calcitriol and these two analogues revealed strong antiproliferative activity against these two targets with maximal growth ..
  100. ncbi The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor
    J O Ward
    Programs of Cell Biology and Human Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Blood 98:3290-300. 2001
    ..These results suggest that PLZF may play an important role in regulating the process by which 1,25(OH)(2)D(3) induces monocytic differentiation in hematopoietic cells...
  101. ncbi Calcitriol down-regulates human ether a go-go 1 potassium channel expression in cervical cancer cells
    Euclides Avila
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan 14000 Mexico, D F, Mexico
    Anticancer Res 30:2667-72. 2010
    Human ether à-go-go-1 (EAG1) potassium channels are promising anticancer targets. Calcitriol has antitumoural properties. This study investigated EAG1 regulation by calcitriol in normal and cancer cells.

Research Grants65

  1. REGULATION OF SKELETAL GROWTH IN RENAL FAILURE
    CHERYL SANCHEZ; Fiscal Year: 2003
    ..b>Calcitriol and recombinant human growth hormone are widely utilized to improve liner growth in children, but large ..
  2. New drug VS-110 for treating inflammatory bowel diseases
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..Vitamin D receptor (VDR), once activated by its endogenous hormone calcitriol (1,25(OH) 2D3), modulates signaling pathways in the inflammation pathway...
  3. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..slightly less hypercalcemic toxic profile (~2-4 fold less toxic than generic Calcijex, the endogenous hormone calcitriol,)...
  4. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..slightly less hypercalcemic toxic profile (~2 to 4 fold less toxic than generic Calcijex, the endogenous hormone calcitriol). A novel VDRM such as VS-105 for treating CKD could potentially achieve annual US sales at $1+ billion...
  5. Vitamin D and Arterial Function in Patients with Chronic Kidney Disease
    Jessica B Kendrick; Fiscal Year: 2013
    ..We hypothesize that the use of calcitriol supplementation in stage IIIB and IV chronic kidney disease patients (CKD) with vitamin D insufficiency or ..
  6. Novel Drug VS-105 for Treatment of Osteoporosis
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2013
    ..VDRMs such as calcitriol are currently used to treat osteoporosis in several ex-US countries...
  7. Vitamin D in Prostate Cancer: Tumor Vasculature Effects
    Candace S Johnson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Calcitriol (vitamin D or 1,25 dihydroxycholecalciferol), a central factor in bone and mineral metabolism, has significant antitumor activity in vitro and in vivo...
  8. A Novel Approach to Phosphorus Lowering in Patients with Chronic Kidney Disease
    Joachim H Ix; Fiscal Year: 2013
    ..of mineral metabolism including urine phosphorus excretion and counter- regulatory hormones FGF23, PTH, and calcitriol are unknown. Changes in these factors may have their own influences on CVD, CKD progression, and bone health...
  9. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..hormone for the treatment of CKD-MBD is pharmacologic preparations of the kidney activated form of vitamin D- calcitriol and analogs such as doxercalciferol...
  10. Insulin Resistance in Chronic Kidney Disease
    Ian H De Boer; Fiscal Year: 2013
    ..action in skeletal muscle is commonly acquired due to unique metabolic abnormalities, including impaired renal calcitriol synthesis, metabolic acidosis, and accumulation of uremic toxins...
  11. Regulation of Bone Mineralization in Renal Osteodystrophy
    ISIDRO BENJAMIN SALUSKY; Fiscal Year: 2012
    ..Large thrice-weekly doses of oral calcitriol or doxercalciferol (1(D2) reduce serum PTH levels and lower bone formation and turnover in patients with ..
  12. Vitamin D Inhibition of HIV and M. Tuberculosis Coinfection in Macrophages
    Stephen A Spector; Fiscal Year: 2010
    ..Of note, our preliminary data suggest that calcitriol the active form of vitamin D3, long associated with possible activity against Mtb, also promotes autophagy and ..
  13. Exploring the interrelationships of mineral metabolism pathways in kidney disease
    Jason Stubbs; Fiscal Year: 2013
    ..specific manipulations will include: 1) the prevention of hyperphosphatemia with phosphate restriction, 2) early calcitriol therapy to counteract the progressive development of 1,25(OH)2D deficiency, 3) early calcimimetic therapy to ..
  14. The effects of 1,25(OH)2D3 on the tumorigenesis of lung squamous cell carcinoma
    SARAH ANNE MAZZILLI; Fiscal Year: 2012
    ..The fact that calcitriol, the active metabolite of vitamin D3, has the ability to induce cell cycle arrest, apoptosis and differentiation ..
  15. Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype
    GEORGE T O'CONNOR; Fiscal Year: 2013
    ..studies will utilize cord blood from healthy, term deliveries to identify the capacity of active vitamin D, calcitriol, to induce IL-10-Treg vs...
  16. The Role of FGF23 in the Pathogenesis of Chronic Kidney Disease
    ANSEL PHILIP AMARAL; Fiscal Year: 2013
    ..FGF23 is a recently discovered endocrine hormone that increases urinary phosphate excretion and inhibits renal calcitriol production...
  17. Assessing and modifying bone quality in chronic kidney disease
    Chris Newman; Fiscal Year: 2013
    ..This is accomplished by calcitriol supplementation...
  18. Calcitonin for treating X-linked hypophosphatemia
    KARL LEONARD INSOGNA; Fiscal Year: 2012
    ..Conventional therapy for XLH with oral phosphate and calcitriol has several limitations including a low therapeutic/toxicity ratio, and a failure to correct growth retardation ..
  19. Novel Biosynthethic Pathway for Secosteroids and the Skin
    Andrzej T Slominski; Fiscal Year: 2013
    ..This defines them as novel endogenous bioregulators. They are at least as potent as 1,25(OH)2D3 (calcitriol) in skin cells displaying anti-proliferative, pro-differentiation and anti-inflammatory properties...
  20. CLINICAL AND GENETIC ANALYSIS OF ADHR
    Michael J Econs; Fiscal Year: 2013
    ..the H193R klotho mutation results in disease;and 9) obtained data indicating that current therapy for XLH with calcitriol and phosphate may worsen elevated FGF23 concentrations...
  21. Encapsulated Active Vitamin D Vaccine for the Treatment of Multiple Sclerosis
    Kristy M Ainslie; Fiscal Year: 2012
    ..targeting leads to in vivo delivery of tolerogenic agents to the DCs, such as the active form of vitamin D (calcitriol)...
  22. Dysregulated Mineral Metabolism in Acute Kidney Injury
    David E Leaf; Fiscal Year: 2013
    ..We will enroll 60 patients and randomly assign them 1:1 to receive a single administration of calcitriol 2mcg IV versus placebo. Participants with AKI will be stratified in equal numbers into the two groups...
  23. Pilot Studies Targeting Mineral Metabolism in Chronic Kidney Disease
    MYLES S WOLF; Fiscal Year: 2013
    ..Rising FGF23 in CKD maintains normal serum phosphate, but also inhibits renal calcitriol production, which causes secondary hyperparathyroidism, and reduces klotho expression, which accelerates ..
  24. Mechanisms of uremic vascular calcification
    Koba A Lomashvili; Fiscal Year: 2013
    ..Vascular calcification will be induced by injecting calcitriol in wild type uremic chimeric mice with vitamid D receptor deficient (VDR-/-) portions of abdominal aorta (..
  25. FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.
    ERIK ALLEN IMEL; Fiscal Year: 2013
    ..impact of FGF23 on phosphate and skeletal metabolism in healthy children, the effect of treatment of XLH with calcitriol and phosphate on FGF23, or the impact of FGF23 on adverse outcomes of XLH therapy...
  26. VITAMIN D RECEPTOR AND REGULATION OF HORMONE RESPONSE
    David Feldman; Fiscal Year: 2010
    ..role of the vitamin D receptor (VDR) in regulating the response to the active hormone, 1,25-dihydroxyvitamin D3 (calcitriol)...
  27. Renal Osteodystrophy and Vascular Calcification
    Keith A Hruska; Fiscal Year: 2013
    ..first, in early CKD causing the CKD-MBD how does the skeleton contribute to vascular calcification (VC);and how calcitriol blocks CKD stimulated VC and inhibits the actions of hyperphosphatemia...
  28. Vitamin D and Hormonal Mechanisms of Cardiovascular Disease in Obesity
    Anand Vaidya; Fiscal Year: 2013
    ..physiologic experimental protocol that is designed to test whether the active vitamin D metabolite, calcitriol, can modulate adipose-tissue RAS activity and influence circulating adiponectin levels in obesity...
  29. Vitamin D, genomics, and asthma morbidity in Puerto Rican children
    John M Brehm; Fiscal Year: 2013
    ..genome-wide survey of VDR binding in bronchial epithelial and smooth muscle cells treated with varying doses of calcitriol. We will then measure genome-wide gene expression in calcitriol-stimulated bronchial epithelial cells treated ..
  30. Anti-Tumor Mechanisms and Therapeutic Effects of Vitamin D
    Donald L Trump; Fiscal Year: 2013
    Abstract Studies in our laboratory demonstrate that vitamin D (1,25 dihydroxycholecalciferol or calcitriol) has significant antitumor activity in vitro and in vivo in a variety of murine, rat and human tumor model systems...
  31. Human Cathelicidin (hCAP18) in Chronic Kidney Disease
    Ishir Bhan; Fiscal Year: 2013
    ..The ability of two different forms of vitamin D therapy (ergocalciferol and calcitriol) to modify hCAP18 levels will be determined.
  32. ROLE OF CHLORIDE IN SODIUM-DEPENDENT HYPERTENSION
    Theodore Kurtz; Fiscal Year: 1990
    ..and electrolytes, and plasma concentrations of renin, aldosterone, catecholamines, parathyroid hormone and calcitriol (1,25-D) will also be determined...
  33. GLUCOCORTICOIDS & VITAMIN D: ROLE IN ANTI-TUMOR EFFECTS
    Candace Johnson; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Vitamin D, 1,25 dihydroxycholecalciferol (calcitriol) has significant antiproliferative activity in vivo and in vitro...
  34. ENDOCHONDRAL BONE FORMATION IN RENAL FAILURE
    ISIDRO SALUSKY; Fiscal Year: 1999
    ..b>Calcitriol and recombinant human growth hormone (rhGH) are widely utilized to improve linear growth in these children...
  35. Evaluation of CYP24 as a Target for Enhancing Vitamin D*
    Donald Trump; Fiscal Year: 2006
    ..In vitro and in vivo calcitriol (1,25 dihydroxycholcalciferol) is antiproliferative and potentiates the antitumor effects of cytotoxic agents (e...
  36. MODULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1993
    Activated macrophages produce the most biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), at inflammatory sites in considerable quantity...
  37. ASYMMETRIC SYNTHESIS OF PHYSIOLOGICALLY ACTIVE COMPOUNDS
    Gary Posner; Fiscal Year: 1992
    1 alpha, 25-Dihydroxyvitamin D3 (calcitriol) is a powerful regulator of calcium metabolism in humans and is used clinically in treating certain calcium metabolic disorders and osteoporosis...
  38. Vitamin D Receptor-Cofactor Interactions as Targets for Novel Drug Discovery
    John Norris; Fiscal Year: 2009
    ..Indeed, two VDR ligands, Calcitriol (1,25-(OH)2D3) and its synthetic analog Alfacalcidol (1alpha-hydroxyvitamin D3), have been approved for the ..
  39. Parathyroid and Thymus Transplants in DiGeorge Syndrome
    MARY MARKERT; Fiscal Year: 2005
    ..Parathyroid function will be considered a success if the patient can be removed from all calcium and calcitriol supplementation...
  40. DIURNAL AND PULSATILE PTH SECRETION IN RENAL FAILURE
    William Goodman; Fiscal Year: 2001
    ..The impact of daily oral and thrice weekly intermittent oral doses of calcitriol on diurnal PTH secretion and pulsatile PTH release in patients with secondary hyperparathyroidism will also be ..
  41. KHCO3 PREVENTS NACL INDUCED BONE RESORPTION IN HUMANS?
    Anthony Sebastian; Fiscal Year: 1999
    ..cyclic AMP, markers of bone resorption (deoxypyridinoline, N-telopeptide); and serum parathyroid hormone, calcitriol, and markers of bone formation (osteocalcin, type I collagen propeptide) will be measured...
  42. Role of FGF-23 in Regulation of Phosphate Homeostasis
    Suzanne Jan de Beur; Fiscal Year: 2004
    ..similar disorders characterized by hypophosphatemia, decreased renal phosphate reabsorption, defective calcitriol synthesis, and defective skeletal mineralization...
  43. REGULATION OF BONE TURNOVER IN RENAL OSTEODYSTROPHY
    M Langub; Fiscal Year: 2003
    ..It is known that parathyroid hormone (PTH), calcitriol, and interleukins act on bone of ESRD patients...
  44. NEGATIVE REGULATION OF GENE EXPRESSION BY VITAMIN D
    NICHOLAS KOSZEWSKI; Fiscal Year: 2002
    Parathyroid hormone (PTH) and calcitriol (1,25(OH)2D3) are key participants in the maintenance of calcium homeostasis in the body...
  45. Calcium, Dairy, and Body Fat in Adolescents
    Connie Weaver; Fiscal Year: 2006
    ..of feeding and that these effects will be associated with a suppression of serum parathyroid hormone (PTH) and calcitriol concentrations...
  46. Serum Vitamin D and Mortality from Eye Melanoma
    Kathleen Egan; Fiscal Year: 2007
    ..The hormonally active form of vitamin D, 1,25(OH)2D3 (calcitriol), is a well-known potent regulator of cell growth and differentiation in cells and tissues expressing the ..
  47. Cardiac Outcomes Associated with Renal Osteodystrophy
    Bryan Kestenbaum; Fiscal Year: 2007
    ..Medication exposures of interest are dosages of phosphate binders and calcitriol. Second, we will recruit a new cohort of 100 dialysis patients from the Northwest Kidney Center and the Veterans&..
  48. RANDOMIZED CALCIUM TRIAL IN HIGH RISK PREGNANCIES
    JORGE PRADA; Fiscal Year: 1999
    ..is a greater need for calcium and a greater increase in serum calcium regulatory hormone concentration (PTH and calcitriol), among adolescent pregnancies and adult multiple gestations compared to adult singleton pregnancy; and, 2) ..
  49. Vitamin D and Dexamethasone in Myelodysplastic Syndromes
    ROBERT REDNER; Fiscal Year: 2003
    ..We have developed a dosing schema of Dexamethasone and calcitriol (the active form of vitamin D) that augments the therapeutic index of calcitriol, and allows for safe ..
  50. OSTEOBLAST PHENOTYPE SUPPRESSION BY PARATHYROID HORMONE
    Ronald Katz; Fiscal Year: 2000
    ..The Osteopontin promoter has response elements for calcitriol (vitamin D3) and phorbol esters, but does not contain a cAMP response element...
  51. MECHANISM OF NON-GENOMIC ACTION OF VITAMIN D
    Keith Hruska; Fiscal Year: 2000
    ..appears to be any question that the vitamin D metabolite, 1alpha,25- dihydroxyvitamin D3 (1alpha,25-(OH)2D3, calcitriol or CT), and its metabolic and synthetic analogs manifest nongenomic actions...
  52. VITAMIN D P450 FUNCTION--NATURAL & DIRECTED MUTAGENESIS
    John Omdahl; Fiscal Year: 2002
    ..enzyme that directs the bioactivation of vitamin D to the pleiotropic hormone 1,25-dihydroxy D3 [1,25(OH)2D3 or calcitriol], which is active in calcium homeostasis, cellular growth and differentiation, and the immune response...
  53. OSTEONECROSIS AMONG RENAL TRANSPLANT RECIPIENTS
    Kenneth Saag; Fiscal Year: 2001
    ..Glucocorticoid dose, markers of bone turnover (NTX, osteocalcin), metabolic diseases (PTH, calcitriol), BMD of the lumbar spine and hip, radiographs and MRI of the femoral head for ON, and responses to quality-of-..
  54. A Phase I/II Clinical Trial of Intravenous (I.V.) Calcitriol with Fixed Doses of
    Nithya Ramnath; Fiscal Year: 2009
    ..In vitro and in vivo calcitriol (1, 25 dihydroxycholcalciferol) is antiproliferative and potentiates the antitumor effects of cytotoxic agents (..
  55. CALCITRIOL IN RECURRENT PROSTATE CANCER
    TOMASZ BEER; Fiscal Year: 2000
    ..Novel agents are needed to delay the progression of prostate cancer in this patient population. Calcitriol is the active metabolite of dietary Vitamin D...
  56. PITUITARY AND BRAIN CALCITRIOL RECEPTORS
    Paula Stern; Fiscal Year: 1980
    ..the proposed work is to identify and characterize receptors for the steroid hormone, 1,25-dihydroxyvitamin D3 (calcitriol) in the pituitary and brain and to determine the functional role of these receptors...
  57. REGULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1992
    ..Vitamin D and its most biologically active metabolite, 1, 25 dihydroxyvitamin-D3 (calcitriol), have been implicated as having significant effects on lymphocyte proliferation, immunoglobulin production and ..
  58. A Novel Vitamin D Target in Human Prostate Cancer
    TOMASZ BEER; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Vitamin D (1,25(OH)2D3, calcitriol) and its analogues show substantial promise for the treatment and prevention of prostate cancer...
  59. Acupuncture for hot flashes in prostate cancer patients
    TOMASZ BEER; Fiscal Year: 2004
    ..The overall goal is to provide prostate cancer patients an effective, low toxicity, non-pharmacologic treatment modality for hot flashes. ..
  60. Resistance and Response Mechanisms to Prostate Cancer Therapy
    TOMASZ BEER; Fiscal Year: 2009
    ..We will test the effectiveness of novel treatments that exploit newly discovered targets in the laboratory and lay the foundation for human trials to develop effective prostate cancer treatment. ..
  61. Oregon Prostate Cancer Conference 2001
    TOMASZ BEER; Fiscal Year: 2003
    ....
  62. REGULATION OF CALCITRIOL ON TPA INDUCED TUMORIGENESIS
    Pi Ling Chang; Fiscal Year: 1999
    DESCRIPTION: The Applicant has observed that calcitriol could enhance 2-O-tetradecanoylphorbol-13-acetate (TPA) - induced tumorigenic transformation of the pre-neoplastic mouse epidermal JB6 line...
  63. REGULATION OF EGF RECEPTORS BY CALCIOTROPIC HORMONES
    Esther Gonzalez; Fiscal Year: 2000
    ..Award which proposes to study the regulation of EGF receptor expression in UMR rat osteoblast-like cells by PTH, calcitriol, and retinoic acid...
  64. CALCITRIOL & DEXAMETHASONE FOR MYELODYSPLASTIC SYNDROMES
    ROBERT REDNER; Fiscal Year: 2004
    ..Abstract Not Provided ..
  65. Calcitriol for Chemoprevention in Preinvasive Bronchial Epithelial Lesions
    Mary Reid; Fiscal Year: 2008
    ..Vitamin D [1,25 dihydroxycholecalciferol (calcitriol)] is a potent anti-proliferative agent in a variety of malignant cell types, including human squamous cell ..