calcifediol

Summary

Summary: The major circulating metabolite of vitamin D3 (CALCIFEROL). It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.

Top Publications

  1. ncbi Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    Armin Zittermann
    Klinik für Thorax und Kardiovaskularchirurgie and Institut für Laboratoriums und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 89:1321-7. 2009
  2. ncbi Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
    Rolf Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Nutr 48:349-54. 2009
  3. ncbi Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study
    John J McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
    Arch Gen Psychiatry 67:889-94. 2010
  4. pmc Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:7711-5. 2004
  5. ncbi Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3
    Zoe Maunsell
    Department of Clinical Biochemistry, Northwick Park Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom
    Clin Chem 51:1683-90. 2005
  6. ncbi C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status
    Ravinder J Singh
    Department of Laboratory Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 91:3055-61. 2006
  7. ncbi A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness
    Yanbin Dong
    Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Endocrinol Metab 95:4584-91. 2010
  8. pmc 25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture
    Xinjian Peng
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Breast Cancer Res Treat 113:31-41. 2009
  9. ncbi Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women
    Allan G Need
    Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, SA, Australia
    Clin Endocrinol (Oxf) 62:738-41. 2005
  10. ncbi Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries
    Pentti Tuohimaa
    Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:104-8. 2004

Detail Information

Publications253 found, 100 shown here

  1. ncbi Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers
    Armin Zittermann
    Klinik für Thorax und Kardiovaskularchirurgie and Institut für Laboratoriums und Transfusionsmedizin, Herzzentrum NRW, Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Am J Clin Nutr 89:1321-7. 2009
    ..However, there is also evidence that calcitriol increases lipogenesis and decreases lipolysis...
  2. ncbi Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
    Rolf Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Nutr 48:349-54. 2009
    ..Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes...
  3. ncbi Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study
    John J McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
    Arch Gen Psychiatry 67:889-94. 2010
    ..Clues from the epidemiology of schizophrenia suggest that low levels of developmental vitamin D may be associated with increased risk of schizophrenia...
  4. pmc Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase
    Jeffrey B Cheng
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:7711-5. 2004
    ..These data identify CYP2R1 as a biologically relevant vitamin D 25-hydroxylase and reveal the molecular basis of a human genetic disease, selective 25-hydroxyvitamin D deficiency...
  5. ncbi Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3
    Zoe Maunsell
    Department of Clinical Biochemistry, Northwick Park Hospital, North West London Hospitals NHS Trust, Harrow, United Kingdom
    Clin Chem 51:1683-90. 2005
    ..Competitive binding techniques are unable to distinguish between the 2 metabolites and suffer from interference from other hydroxy metabolites of vitamin D...
  6. ncbi C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status
    Ravinder J Singh
    Department of Laboratory Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 91:3055-61. 2006
    ..During subsequent clinical use, we identified significantly elevated results in some infants. We hypothesized this might represent assay interference caused by C-3 epimers of 25OHD(2) or 25OHD(3)...
  7. ncbi A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness
    Yanbin Dong
    Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Endocrinol Metab 95:4584-91. 2010
    ..Vitamin D insufficiency/deficiency is commonly observed in black youth...
  8. pmc 25-Hydroxyvitamin D3 is a natural chemopreventive agent against carcinogen induced precancerous lesions in mouse mammary gland organ culture
    Xinjian Peng
    IIT Research Institute, 10 West 35th Street, Chicago, IL 60616, USA
    Breast Cancer Res Treat 113:31-41. 2009
    ..We conclude that 25(OH)D(3) could serve as a non-toxic natural chemopreventive agent for further development for breast cancer prevention...
  9. ncbi Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women
    Allan G Need
    Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, University of Adelaide, Adelaide, SA, Australia
    Clin Endocrinol (Oxf) 62:738-41. 2005
    ....
  10. ncbi Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries
    Pentti Tuohimaa
    Medical School, University of Tampere, Tampere, Finland
    Int J Cancer 108:104-8. 2004
    ..It is recommended that vitamin D deficiency be supplemented, but too high vitamin D serum level might also enhance cancer development...
  11. ncbi Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol
    Britta Diesel
    Institut fur Humangenetik, Theoretische Medizin, Universitat des Saarlandes, Saarbrucken, Germany
    Clin Cancer Res 11:5370-80. 2005
    ..A better understanding of the vitamin D(3) metabolism is required to evaluate its potential therapeutic value for cancers. Here, we set out to contribute to the understanding of vitamin D(3) metabolism in glioblastoma multiforme...
  12. ncbi Risk factors for variation in 25-hydroxyvitamin D₃ and D₂ concentrations and vitamin D deficiency in children
    Anna Maija Tolppanen
    Medical Research Council, Centre for Causal Analysis in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, 15 23 Oakfield Grove, Clifton, Bristol BS8 2BN, United Kingdom
    J Clin Endocrinol Metab 97:1202-10. 2012
    ..Suboptimal vitamin D status is common and associated with adverse health outcomes...
  13. ncbi Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion
    Daniel Zehnder
    Division of Medical Sciences, The University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK
    J Am Soc Nephrol 13:621-9. 2002
    ..The rapid induction of endothelial 1alpha-OHase activity by inflammatory cytokines suggests a novel autocrine/paracrine role for the enzyme, possibly as a modulator of endothelial cell adhesion...
  14. ncbi 25-Hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand
    Yan Ru Lou
    Department of Anatomy, Medical School, University of Tampere, Tampere, FIN 33014, Finland
    J Steroid Biochem Mol Biol 118:162-70. 2010
    ..In conclusion, 25-hydroxyvitamin D(3) is an agonistic vitamin D receptor ligand with gene regulatory and anti-proliferative properties...
  15. ncbi 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis
    K Takeyama
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113, Japan
    Science 277:1827-30. 1997
    ..These results indicate that the negative feedback regulation of active vitamin D synthesis is mediated by 1alpha(OH)ase through liganded VDR...
  16. pmc Serum 25-hydroxyvitamin D3 levels are associated with breslow thickness at presentation and survival from melanoma
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James s Hospital, Beckett St, Leeds LS9 7TF, United Kingdom
    J Clin Oncol 27:5439-44. 2009
    ..A cohort study was carried out to test the hypothesis that higher vitamin D levels reduce the risk of relapse from melanoma...
  17. pmc Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Carcinogenesis 30:769-76. 2009
    ..Results from the most comprehensive evaluation of serum vitamin D and its related genes to date suggest that tag SNPS in the 3' UTR of VDR may be associated with risk of prostate cancer in men with low vitamin D status...
  18. ncbi Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption
    M Janet Barger-Lux
    Osteoporosis Research Center, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 87:4952-6. 2002
    ..Despite this input, at the late winter visit, 25(OH)D was less than 50 nmol/liter in 3 subjects and less than 75 nmol/liter in 15 subjects...
  19. ncbi Blood vitamin levels in dogs with chronic kidney disease
    A Galler
    Department for Companion Animals and Horses, Clinic for Internal Medicine and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Vet J 192:226-31. 2012
    ..Whether lower vitamin D and folate concentrations in dogs with CKD justify supplementation has to be evaluated in future studies...
  20. pmc Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood: cross-sectional findings from the Avon Longitudinal Study of Parents and Children
    Dylan M Williams
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, United Kingdom
    J Clin Endocrinol Metab 97:1563-71. 2012
    ..Evidence of associations in children, however, is limited, and it is unknown whether associations with risk factors differ for each 25-hydroxyvitamin D analog [25-hydroxyvitamin D(2) (25[OH]D(2)) and 25-hydroxyvitamin D(2) (25[OH]D(3))]...
  21. ncbi Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant
    Pramila Kalra
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India
    Br J Nutr 108:1052-8. 2012
    ..These differences were still evident at 9 months. We conclude that both 1500 μg and two doses of 3000 μg vitamin D₃ had a beneficial effect on infant anthropometry, the larger dose also improving CB ALP and maternal 25(OH)D...
  22. ncbi Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity
    Heike Annette Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich and Waid City Hospital Zurich, Zurich, Switzerland
    J Bone Miner Res 27:160-9. 2012
    ....
  23. pmc An inflection point of serum 25-hydroxyvitamin D for maximal suppression of parathyroid hormone is not evident from multi-site pooled data in children and adolescents
    Kathleen M Hill
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47906, USA
    J Nutr 140:1983-8. 2010
    ....
  24. ncbi A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention
    Heli T Viljakainen
    Calcium Research Unit, Department of Applied Chemistry and Microbiology, University of Helsinki, Helsinki, Finland
    J Bone Miner Res 21:836-44. 2006
    ..Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers...
  25. ncbi Elevated plasma calcifediol is associated with aggressive periodontitis
    Kaining Liu
    Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China
    J Periodontol 80:1114-20. 2009
    ..Serum calcifediol was demonstrated to be potentially associated with periodontal disease...
  26. ncbi Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women
    Bess Dawson-Hughes
    Bone Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:1763S-6S. 2004
    ..Broad-based vitamin D supplementation is needed to remove vitamin D insufficiency as a contributing cause of osteoporosis...
  27. doi Serum 25-OH vitamin D2 and D3 are stable under exaggerated conditions
    John G Lewis
    Clin Chem 54:1931-2. 2008
  28. ncbi Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: a 3-y prospective study
    Marjo K M Lehtonen-Veromaa
    Paavo Nurmi Centre, Sport and Exercise Medicine Unit, Department of Physiology, University of Turku, Turku, Finland
    Am J Clin Nutr 76:1446-53. 2002
    ..Little is known about the effect of vitamin D status on bone gain in adolescents...
  29. ncbi Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells
    Xinjian Peng
    IIT Research Institute, Chicago, Illinois 60616, USA
    J Cell Biochem 110:1324-33. 2010
    ..These data suggest that there is a significant protective role for 25(OH)D(3) against cellular stress in the breast epithelial cells and these effects may be mediated by altered miRNA expression...
  30. ncbi The urgent need to recommend an intake of vitamin D that is effective
    Reinhold Vieth
    Am J Clin Nutr 85:649-50. 2007
  31. ncbi Vitamin D status in renal transplant recipients
    A Stavroulopoulos
    Nottingham Renal and Transplant Unit, Nottingham University Hospitals, City Campus, Nottingham, UK
    Am J Transplant 7:2546-52. 2007
    ..In conclusion 25-OHD was low in virtually all of our renal transplant recipients and may aggravate secondary hyperparathyroidism, but its correction may be difficult in patients with hypercalcaemia...
  32. ncbi 25-Hydroxyvitamin D(3) suppresses PTH synthesis and secretion by bovine parathyroid cells
    C S Ritter
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Kidney Int 70:654-9. 2006
    ..Clotrimazole enhanced 24-hydroxylase mRNA induction, presumably by inhibiting catabolism of 25(OH)D(3). In conclusion, 25(OH)D(3) suppresses PTH synthesis by parathyroid cells, possibly by direct activation of the VDR...
  33. pmc Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight
    A Sita-Lumsden
    Department of Respiratory Medicine, Guy s and St Thomas Foundation Trust, London, UK
    Thorax 62:1003-7. 2007
    ....
  34. ncbi No association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III
    John McGrath
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Australia
    Neuroepidemiology 29:49-54. 2007
    ..We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D(3) [25(OH)D] levels and performance on various cognitive tasks, based on a large, representative community sample...
  35. ncbi Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes
    Katinka Stoffels
    Laboratory for Experimental Medicine and Endocrinology LEGENDO, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    J Bone Miner Res 21:37-47. 2006
    ..Cross-talk between the JAK-STAT, the NF-kappaB, and the p38 MAPK pathways is necessary, and direct binding of C/EBPbeta to its recognition sites in the promoter of the 1alpha-hydroxylase gene is a prerequisite...
  36. ncbi 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 87:1738-42. 2008
    ..Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans...
  37. ncbi Association between vitamin D and bone mineral density in Iranian postmenopausal women
    Farhad Hosseinpanah
    Obesity Research Center, Research Institute for Endocrine Sciences, Shaheed Beheshti University of Medical Sciences, PO Box 193 4763, Tehran, Iran
    J Bone Miner Metab 26:86-92. 2008
    ..However, BMD was associated inversely with LnPTH only in femoral neck but not in the other sites. This study did not show any association between 25(OH)D and BMD in free-living Iranian postmenopausal women...
  38. ncbi Accuracy and clinical implications of seven 25-hydroxyvitamin D methods compared with liquid chromatography-tandem mass spectrometry as a reference
    Heinz Jürgen Roth
    Limbach Laboratory, Department of Endocrinology and Oncology, Im Breitspiel 15, 69126 Heidelberg, Germany
    Ann Clin Biochem 45:153-9. 2008
    ..High variability in 25(OH)D measurements due to utilized test and assay technologies and the lack of standardization against reference materials and reference method often confounds proper assessment of vitamin D status...
  39. ncbi Regulation of TNF-alpha by 1alpha,25-dihydroxyvitamin D3 in human macrophages from CAPD patients
    M L Cohen
    Departments of Clinical Biochemistry and Nephrology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Soroka Medical Center, Beer Sheva, Israel
    Kidney Int 59:69-75. 2001
    ..We hypothesize that 1alpha, 25(OH)2D3 may constitute a regulatory mechanism that, by controlling the intensity of the inflammatory response of the peritoneum, will moderate tissue damage during peritonitis...
  40. ncbi The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients
    A M Borissova
    Department of Endocrinology, University Hospital, 6 Damjan Gruev str, 1303 Sofia, Bulgaria
    Int J Clin Pract 57:258-61. 2003
    ..Our results suggest that vitamin D3 supplementation could be an element in the complex treatment of type 2 diabetes mellitus during the winter...
  41. ncbi Initial periodontal therapy reduced systemic and local 25-hydroxy vitamin D(3) and interleukin-1beta in patients with aggressive periodontitis
    Kaining Liu
    Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China
    J Periodontol 81:260-6. 2010
    ..In the present study, the influence of initial periodontal therapy on systemic and local levels of 25-hydroxy vitamin D(3) and three related elements (osteocalcin and interleukin-1beta and -6) in patients with GAgP was investigated...
  42. ncbi Potentially modifiable determinants of vitamin D status in an older population in the Netherlands: the Hoorn Study
    Rob M van Dam
    Institute for Health Sciences, Vrije Universiteit Amsterdam, Netherlands
    Am J Clin Nutr 85:755-61. 2007
    ..Inadequate vitamin D status is common in many populations around the world...
  43. ncbi Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults
    Jared P Reis
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, California 92093 0607, USA
    Diabetes Care 30:1549-55. 2007
    ..We examined the association of 25(OH)D and PTH with the prevalence of metabolic syndrome in a community-based cohort of older adults...
  44. ncbi Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard
    Elina Hypponen
    Centre for Pediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Clin Endocrinol Metab 92:4615-22. 2007
    ..Variation between 25(OH)D assays hampers between-study comparisons and the definition of relevant cutoffs for hypovitaminosis D...
  45. ncbi A cross-sectional study on biochemical parameters of bone turnover and vitamin d metabolites in healthy dutch children and young adults
    Inge M van der Sluis
    Department of Pediatrics, Subdivision Endocrinology, Sophia Children s Hospital Rotterdam, The Netherlands
    Horm Res 57:170-9. 2002
    ..To provide reference data of biochemical markers of bone turnover and vitamin D metabolites for children and young adults...
  46. ncbi Rapid HPLC method for measurement of vitamin D3 and 25(OH)D3 in blood plasma
    A A Olkowski
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, Canada S7N 5A8
    Int J Vitam Nutr Res 73:15-8. 2003
    ..With a significantly shortened time of analysis (10 minutes), the present method allows the possibility for processing of a large number of samples rapidly, efficiently, and at a low cost...
  47. ncbi 25-hydroxy-vitamin d metabolism in human colon cancer cells during tumor progression
    P Bareis
    Department of Pathophysiology, University of Vienna Medical School, Vienna, A-1090, Austria
    Biochem Biophys Res Commun 285:1012-7. 2001
    ....
  48. ncbi Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients
    Giovanni Targher
    Division of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Clin Endocrinol (Oxf) 65:593-7. 2006
    ..To estimate the prevalence of hypovitaminosis D among type 2 diabetic adults and to assess the relationship between hypovitaminosis D and intimal medial thickening (IMT) of the common carotid artery, a marker of preclinical atherosclerosis...
  49. ncbi Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse
    Sonoko Masuda
    Department of Biochemistry, Queen s University, Kingston Ontario, Canada K7L 3N6
    Endocrinology 146:825-34. 2005
    ..These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis...
  50. pmc A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1)
    O Guryev
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Proc Natl Acad Sci U S A 100:14754-9. 2003
    ..Although the physiological importance of these hydroxylated metabolites of D3 and their in vivo formation and mode of action remain to be determined, the rate with which they are formed by CYP11A1 in vitro suggests an important role...
  51. ncbi Estimation of the dietary requirement for vitamin D in healthy adolescent white girls
    Kevin D Cashman
    School of Food and Nutritional Sciences, Department of Medicine, University College Cork, Cork, Ireland
    Am J Clin Nutr 93:549-55. 2011
    ..Knowledge gaps have contributed to considerable variation (between 0 and 15 μg/d) in international dietary recommendations for vitamin D in adolescents...
  52. ncbi Changes in vitamin D binding protein and vitamin D concentrations associated with liver transplantation
    PETER P REESE
    Renal Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Liver Int 32:287-96. 2012
    ..Vitamin D deficiency is associated with fractures, infections and death. Liver disease impairs vitamin D and vitamin D binding protein (DBP) metabolism...
  53. ncbi Optimal serum calcidiol concentration for cancer prevention
    P Tuohimaa
    Medical School, 33520 University of Tampere, Tampere, Finland
    Anticancer Res 32:373-81. 2012
    ..In these cells, calcidiol and calcitriol act synergistically, therefore fluctuations of the serum calcidiol concentration may define the hormonal activity and cancer development...
  54. ncbi Vitamin D status in relation to nutritional depletion and muscle function in patients with advanced pulmonary disease
    L Førli
    Department of Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Exp Lung Res 35:524-38. 2009
    ..Low serum calcidiol concentration was associated with fat mass, lung obstruction, and low intake of vitamin D, especially in the underweight patients, and calcidiol was a predictor of walking distance...
  55. ncbi High prevalence of vitamin D deficiency in African American kidney transplant recipients
    Shreyank S Tripathi
    Division of Nephrology, Department of Internal Medicine, Virginia Commonwealth University Health System, Richmond, VA 23298 0160, USA
    Transplantation 85:767-70. 2008
    ..01) and alkaline phosphatase level was positively associated with intact PTH levels (P<0.002). Vitamin D(3) deficiency and insufficiency is present in most of the African American kidney transplant patients...
  56. ncbi Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone
    C Brot
    Osteoporosis Research Clinic, Dep 545, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Br J Nutr 86:S97-103. 2001
    ..Thus, we have shown, that healthy middle-aged Danish women are prone to vitamin D insufficiency in the winter-spring period, if they avoid sun exposure in the summer period and abstain from vitamin D supplementation...
  57. ncbi Vitamin D and the risk of acute allograft rejection following human liver transplantation
    Davide Bitetto
    DPMSC Medical Liver Transplantation Unit, Internal Medicine, University of Udine, Udine, Italy
    Liver Int 30:417-44. 2010
    ..Vitamin D may act as an immune modulator in experimental and human organ transplantation, but these data are yet to be confirmed in human liver transplantation (LT)...
  58. ncbi Double treatment with paricalcitol-associated calcifediol and cardiovascular risk biomarkers in haemodialysis
    Celestino Piñera-Haces
    Servicio de Nefrología Hospital Universitario Marqués de Valdecilla Universidad de Cantabria Santander, Spain
    Nefrologia 33:77-84. 2013
    ..Currently, there is still controversy regarding the type of supplementation needed by CKD patients on HD...
  59. ncbi Barriers to optimizing vitamin D3 intake for the elderly
    Robert P Heaney
    Creighton University, Omaha, NE 68178, USA
    J Nutr 136:1123-5. 2006
    ..The age-related decline in cutaneous input, taken together with the UL, creates a substantial barrier to the deployment of public health strategies to optimize vitamin D status in the elderly...
  60. ncbi Serum concentrations of 1,25-dihydroxycholecalciferol and 25-hydroxycholecalciferol in clinically normal dogs and dogs with acute and chronic renal failure
    Bernhard Gerber
    Clinic for Small Animal Internal Medicine, Faculty of Veterinary Medicine, University of Zurich, Winterthurstrasse 260, 8057 Zurich, Switzerland
    Am J Vet Res 64:1161-6. 2003
    ..To compare serum concentrations of 1,25-dihydroxycholecalciferol (1,25-[OH]2D3) and 25-hydroxycholecalciferol (25-[OH]D3) in healthy control dogs and dogs with naturally occurring acute renal failure (ARF) and chronic renal failure (CRF)...
  61. ncbi Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color
    Laura A G Armas
    Creighton University Medical Center, Omaha, Nebraska 68131, USA
    J Am Acad Dermatol 57:588-93. 2007
    ..Ultraviolet (UV)-B light increases vitamin D levels, but the dose response and the effect of skin pigmentation have not been well characterized...
  62. ncbi Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease
    Martin Hewison
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:316-21. 2007
    ..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues...
  63. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  64. ncbi Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D
    Bruce W Hollis
    Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Nutr 135:317-22. 2005
    ..Recent studies reveal that current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation...
  65. ncbi Automated measurement of 25-OH vitamin D3 on the Roche Modular E170 analyzer
    Aila Leino
    TYKSLAB, the Hospital District of Southwest Finland, Turku, Finland
    Clin Chem 54:2059-62. 2008
    ..We assessed the analytical performance of the Elecsys 25-OH-D(3) assay on a Roche Modular E 170 analyzer...
  66. ncbi Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men
    Juha Petri Ruohola
    Research Institute of Military Medicine, Helsinki, Finland
    J Bone Miner Res 21:1483-8. 2006
    ..The average serum 25(OH)D concentration was significantly lower in the group with fracture, suggesting a relationship between vitamin D and fatigue bone stress fracture...
  67. ncbi Assessing vitamin D status: pitfalls for the unwary
    Jeffrey K C Lai
    National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT, Australia
    Mol Nutr Food Res 54:1062-71. 2010
    ..Newer assays using alternative biological samples to determine the circulating 25(OH)D have been proposed and advances in the genetics of vitamin D and the role of vitamin D-binding protein may improve future assay accuracy...
  68. ncbi A sensitive LC/MS/MS assay of 25OH vitamin D3 and 25OH vitamin D2 in dried blood spots
    Darryl Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Q4076, Australia
    Clin Chim Acta 403:145-51. 2009
    ..While a number of methods exist to measure 25OHD in sera, none have been specifically developed to examine dried blood spots (DBS)...
  69. ncbi Review: vitamin D, immunity and lupus
    M Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova Italy
    Lupus 17:6-10. 2008
    ..Treatment of vitamin D deficiency could be particularly important in SLE patients due to concomitant insults on their tissues such as bone, and in view of the possible immunomodulatory effects exerted by vitamin D...
  70. pmc Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity
    Anne Thea McGill
    University of Auckland Human Nutrition Unit, University of Auckland, Auckland, New Zealand
    Nutr J 7:4. 2008
    ..In the current study, serum vitamin D3 was inversely related to weight, BMI and markers of TIIDM (large waist, raised HbA1c) but not to adipose mass nor to MetSyn per se...
  71. ncbi Vitamin D deficiency in veiled or dark-skinned pregnant women
    S R Grover
    Royal Women's Hospital, Melbourne, Vic
    Med J Aust 175:251-2. 2001
    ..5-93.8 nmol/L). CONCLUSIONS: Our findings are a cause for concern, because vitamin D deficient women are at risk of bone disease and their children at risk of neonatal hypocalcaemia and rickets...
  72. ncbi 25-hydroxyvitamin D3 is an active hormone in human primary prostatic stromal cells
    Yan Ru Lou
    Department of Anatomy, Medical School, FIN 33014, University of Tampere, Finland
    FASEB J 18:332-4. 2004
    ..Altogether our results suggest that 25OHD3 at a high but physiological concentration acts as an active hormone with respect to vitamin D3 responsive gene regulation and suppression of cell proliferation...
  73. pmc Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity
    Andrzej T Slominski
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e9907. 2010
    ..UVB induces transformation of the steroidal 5,7-dienes to pregnacalciferol (pD) and a lumisterol-like compounds (pL)...
  74. ncbi Measurement of 25-hydroxyvitamin D3 (25OHD3) and 25-hydroxyvitamin D2 (25OHD2) in human serum using liquid chromatography-tandem mass spectrometry and its comparison to a radioimmunoassay method
    Huiping Chen
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Chim Acta 391:6-12. 2008
    ..We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to measure 25OHD(3) and 25OHD(2) in human serum and compared it to the traditionally used DiaSorin radioimmunoassay (RIA)...
  75. ncbi Proximal tubule endocytic apparatus as the specific renal uptake mechanism for vitamin D-binding protein/25-(OH)D3 complex
    Armando Luis Negri
    Physiology and Biophysics Department, Universidad del Salvador School of Medicine, Buenos Aires, Argentina
    Nephrology (Carlton) 11:510-5. 2006
    ....
  76. ncbi Quantification of serum 25-hydroxyvitamin D(2) and D(3) using HPLC-tandem mass spectrometry and examination of reference intervals for diagnosis of vitamin D deficiency
    Amy K Saenger
    Department of Laboratory Medicine, University of Washington Medical Center and Harborview Medical Center, Seattle, WA 98195, USA
    Am J Clin Pathol 125:914-20. 2006
    ..This LC-MS/MS method provides a rapid, accurate, sensitive, and cost-effective alternative to other methods for detection of 25(OH)D(2) and 25(OH)D(3) at nanomolar concentrations...
  77. ncbi C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation
    Maya Kamao
    Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe 658 8558, Japan
    J Biol Chem 279:15897-907. 2004
    ..These results indicate that C-3 epimerization may be a common metabolic pathway for the major metabolites of vitamin D3...
  78. pmc Vitamin D metabolism and action in human bone marrow stromal cells
    Shuanhu Zhou
    Department of Orthopedic Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Endocrinology 151:14-22. 2010
    ....
  79. ncbi Inappropriate serum levels of retinol, alpha-tocopherol, 25 hydroxyvitamin D3 and 24,25 dihydroxyvitamin D3 levels in healthy Spanish adults: simultaneous assessment by HPLC
    J M Mata-Granados
    SANYRES GRUPO PRASA, E 14012, Cordoba, Spain
    Clin Biochem 41:676-80. 2008
    ..Simultaneous assessment of the status of lipid-soluble vitamins; retinol, alpha-tocopherol, 25 hydroxyvitamin D(3) and 24,25 dihydroxyvitamin D(3) in serum of blood donors, paradigm of a healthy population...
  80. ncbi Prostatic 25-hydroxyvitamin D-1alpha-hydroxylase and its implication in prostate cancer
    Tai C Chen
    Vitamin D, Skin and Bone Research Laboratory, Division of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    J Cell Biochem 88:315-22. 2003
    ..Thus, the results suggest that the defect in enzyme activity may result from the decreased promoter activity in prostate cancer cells...
  81. ncbi Biochemical effects of calcifediol supplementation in mild, asymptomatic, hyperparathyroidism with concomitant vitamin D deficiency
    M Luisa Isidro
    Endocrine Department, Complejo Hospitalario Universitario, As Xubias 84, A Coruna, 15006, Spain
    Endocrine 36:305-10. 2009
    ..Twenty-seven patients were included in this study. Calcifediol was started at a dose of 480-960 IU/24 h (8-16 microg/24 h) and adjusted up to a maximum of 960 IU/24 h (16 ..
  82. ncbi Occupational exposure to solar UVB and seasonal monitoring of serum levels of 25-hydroxy vitamin D3: a case-control study
    Esther Azizi
    Department of Dermatology, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Photochem Photobiol 85:1240-4. 2009
    ..In the rest of the year 25-OH-D3 ranged between >or=20.0 and 29.0 ng mL(-1). Monitoring 25-OH-D3 may disclose undesirable vitamin D status following reduced sun exposure for skin cancer prevention among outdoor workers...
  83. ncbi High latitude and marine diet: vitamin D status in elderly Faroese
    Christine Dalgård
    Department of Environmental Health, Institute of Public Health, University of Southern Denmark, JB Winslowsvej 17, 2nd Floor, 5000 Odense C, Denmark
    Br J Nutr 104:914-8. 2010
    ..Thus, even in a population with a high intake of marine food, the northern latitude causes a low vitamin D status. Efforts to improve vitamin D status in this population are warranted...
  84. ncbi Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition
    J Y Hsu
    Department of Medicine, Stanford University School of Medicine, California 94305, USA
    Cancer Res 61:2852-6. 2001
    ..This finding has ramifications for both the prevention and therapy of prostate cancer with vitamin D compounds...
  85. ncbi Vitamin D insufficiency in North America
    David A Hanley
    Division of Endocrinology and Metabolism, Departments of Medicine and Oncology, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    J Nutr 135:332-7. 2005
    ..The response to vitamin D supplementation in clinical trials suggests current recommendations for dietary intake of this vitamin are too low and that a higher adequate intake should be recommended...
  86. ncbi Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis
    Sanjeev Patel
    St Helier University Hospital, Carshalton, London, UK
    Arthritis Rheum 56:2143-9. 2007
    ....
  87. ncbi Application of 4-(4-nitrophenyl)-1,2,4-triazoline-3,5-dione to analysis of 25-hydroxyvitamin D3 in human plasma by liquid chromatography/electron capture atmospheric pressure chemical ionization-mass spectrometry
    Tatsuya Higashi
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Anal Sci 19:941-3. 2003
    ..This derivatization-LC/ECAPCI-MS method was applied to a plasma 25-hydroxyvitamin D3 assay, and gave satisfactory results in sensitivity, specificity, measurable range and throughput of the analysis...
  88. ncbi Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences
    G Ruiz-Irastorza
    Servicio de Medicina Interna, Hospital de Cruces, 48903 Bizkaia, Spain
    Rheumatology (Oxford) 47:920-3. 2008
    ..We aimed to establish the prevalence, predictors and clinical consequences of vitamin D deficiency in patients with SLE...
  89. pmc 20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation
    Blazej Zbytek
    Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Invest Dermatol 128:2271-80. 2008
    ..These data imply that the previously unreported pathway of vitamin D3 metabolism by P450scc may have wider biological implications depending, for example, on the extent of adrenal gland or cutaneous metabolism...
  90. ncbi Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults: response to Reis et al
    Giuseppe Lippi
    Diabetes Care 30:e135; author reply e136. 2007
  91. ncbi Vitamin D metabolism in peripheral blood mononuclear cells is influenced by chewing "betel nut" (Areca catechu) and vitamin D status
    William B Ogunkolade
    Center for Diabetes and Metabolic Medicine, Royal London Hospital, London E1 1BB, United Kingdom
    J Clin Endocrinol Metab 91:2612-7. 2006
    ..We previously reported that circulating 1,25(OH)(2)D contributed to determination of VDR-protein levels and VDR genotype was a determinant of both VDR mRNA and VDR-protein in South Asians...
  92. ncbi [The photobiology of vitamin D--a topic of renewed focus]
    Johan Moan
    Avdeling for strålingsbiologi, Rikshospitalet Radiumhospitalet, 0310 Oslo
    Tidsskr Nor Laegeforen 126:1048-52. 2006
    ....
  93. ncbi Effect of cinacalcet on hypercalcemia and bone mineral density in renal transplanted patients with secondary hyperparathyroidism
    Carlos Bergua
    Department of Nephrology and Renal Transplantation, Hospital Clinic, Barcelona, Spain
    Transplantation 86:413-7. 2008
    ..This study prospectively evaluates the effects of cinacalcet therapy on serum calcium (SCa) and parathyroid hormone (PTH) blood levels, and basically on bone mineral density (BMD) in RT patients with persistent hyperparathyroidism...
  94. ncbi Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Mount Sinai Hospital, Toronto, M5G 1L5, Canada
    J Nutr 136:1117-22. 2006
    ....
  95. ncbi Effect of vitamin D and calcium supplementation on bone turnover in institutionalized adults with Down's Syndrome
    P Zubillaga
    Fundacion Uliazpi, Portu Etxe 53, 20018 San Sebastian, Gipuzkoa, Spain
    Eur J Clin Nutr 60:605-9. 2006
    ..To assess the status of vitamin D and the effects of calcium and vitamin D3 supplementation on the bone metabolism in a group of adults with Down's syndrome (DS)...
  96. ncbi Calcimimetics for predialysis patients?
    Albert Fournier
    Am J Kidney Dis 47:196; author reply 196-7. 2006
  97. ncbi Limited availability of nutritional vitamin D causing inappropriate treatment of vitamin D deficiency rickets with a response resembling pseudohypoparathyroidism type II in a Japanese patient
    Y Inamo
    Division of Pediatric Rheumatology and Endocrinology, Department of General Pediatrics, Nihon University Nerima Hikarigaoka Hospital, Nihon University School of Medicine, Tokyo, Japan
    J Endocrinol Invest 28:834-7. 2005
    ..However, because neither is commercially available as a useful formulation in Japan, physicians are forced to inappropriately use calcitriol or analogs...
  98. doi Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease
    Mervet Rouached
    Kidney Int 74:389-90. 2008
  99. ncbi Vitamin D deficiency during various stages of pregnancy in the rat; its impact on development and behaviour in adult offspring
    Darryl W Eyles
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD 4076, Australia
    Psychoneuroendocrinology 32:227-34. 2007
    ..These findings suggest there may be a therapeutic window for maternal dietary intervention in the DVD model of psychosis...
  100. ncbi Determinants of vitamin D levels in nursing home residents
    Paul J Drinka
    Wisconsin Veterans Home, King, WI 54946, USA
    J Am Med Dir Assoc 8:76-9. 2007
    ..To determine the effect of various doses of vitamin D(2) and D(3), as well as ambulatory status (a surrogate for sun exposure), on 25-OH-D levels...
  101. ncbi [Vitamin D: looking for optimum level]
    Maria Teresa Del Campo
    Med Clin (Barc) 127:651-2. 2006

Research Grants62

  1. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..The results of the studies will advance our knowledge on how vitamin D can be used as a therapeutic agent to improve inflammation in humans. ..
  2. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ....
  3. Safe and Effective Vitamin D Supplementation in HIV
    Virginia A Stallings; Fiscal Year: 2012
    ..Inexpensive and easy to administer, vitamin D supplementation may prove to be an effective and feasible treatment for symptoms and prevention of side effects for people of all ages living with HIV/AIDS in the US and around the world. ..
  4. Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast Cancer
    Glendon M Zinser; Fiscal Year: 2010
    ..The proposed studies are of an important and under- investigated area of mammary gland biology that may serve as a nutritional preventative and/or therapeutic option to fight breast cancer. ..
  5. The effect of vitamin D on the clinical and imaging course of multiple sclerosis
    Ellen M Mowry; Fiscal Year: 2013
    ....
  6. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
  7. VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL WOMEN
    John Aloia; Fiscal Year: 2002
    ..If this randomized clinical trial demonstrates a positive effect on prevention of bone loss, a large scale multi-centered trial with fracture prevention as an endpoint will have merit. ..
  8. ASYMMETRIC SYNTHESIS OF PHYSIOLOGICALLY ACTIVE COMPOUNDS
    Gary Posner; Fiscal Year: 1992
    ....
  9. VITAMIN D METABOLISM IN SARCOIDOSIS AND LYMPHOMA
    John Adams; Fiscal Year: 1992
    ....
  10. Biology of a Novel Phosphaturic Protein - sFRP-4
    Rajiv Kumar; Fiscal Year: 2007
    ..Our findings will have important implications with respect to Pi homeostasis, bone mineralization in mammals and humans, and the regulation of ion transport through Wnt signaling in the kidney. ..
  11. Serum Vitamin D and Mortality from Eye Melanoma
    Kathleen Egan; Fiscal Year: 2007
    ..If the proposed hypotheses are supported, findings may offer novel insights, and point to new strategies for cancer control. [unreadable] [unreadable] [unreadable]..
  12. Dairy Products, Calcium, and Risk of Prostate Cancer
    I Min Lee; Fiscal Year: 2004
    ..We also will examine men aged <65, 65-74, and 75+ years. This large database provides a unique and cost-effective opportunity to answer questions of public health importance. ..
  13. VITAMIN D--CHEMICAL AND RELATED STUDIES
    WILLIAM OKAMURA; Fiscal Year: 2001
    ....
  14. Serum Vitamin D, Genetic Polymorphisms & Ovarian Cancer
    Alan Arslan; Fiscal Year: 2005
    ..abstract_text> ..
  15. VITAMIN D3 TO REDUCE SUPPRESSOR CELLS IN CANCER PATIENTS
    M Rita Young; Fiscal Year: 1999
    ..Upon completion, these studies will show if vitamin D3 treatment of patients whose cancers mobilize CD34+ NS cells will induce dendritic cells capable of stimulating immune reactivity to autologous cancer. ..
  16. CALCIDIOL THERAPY FOR PROSTATE CANCER
    Gary Schwartz; Fiscal Year: 2000
    ..Determine the possible toxicity of 25-OH-D by measuring serum 1,25(OH)2D, calcium, and body weight. 3. Correlate 25-OH-D treatment with tumor markers in the xenografts and with histological differentiation of the normal mouse prostates. ..
  17. REGULATION OF THE IMMUNE RESPONSE BY VITAMIN D
    William Rigby; Fiscal Year: 1992
    ....
  18. KIDNEY CELL CULTURE: REGULATION OF CALCIUM METABOLISM
    Helen Henry; Fiscal Year: 1990
    ....
  19. SIDE CHAIN METABOLISM OF VITAMIN D
    Satyanarayana Reddy; Fiscal Year: 1992
    ..This information may also influence our future research into the understanding of the pathogenesis of some of the disease states where there is disturbed vitamin D metabolism...
  20. INSULIN AND RENAL METABOLISM OF 25-HYDROXYVITAMIN D3
    Helen Henry; Fiscal Year: 1980
    ..The results of these studies will increase the understanding of how and why calcium metabolism is perturbed by changes in insulin status and may lead to better understanding and management of patients with diabetes mellitus. ..
  21. Bone-Sparing by Ca Salts With & Without Extra Phosphorus
    Robert Heaney; Fiscal Year: 2008
    ..1 Description, ..
  22. BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS
    Robert Heaney; Fiscal Year: 2001
    ....
  23. Establishing the Vitamin D Requirements During Lactation
    Bruce W Hollis; Fiscal Year: 2010
    ..The findings of this study will generate important new information for health care professionals and policy makers with regard to vitamin D requirements and the potential benefit to both mother and infant. ..
  24. Evaluation of Vitamin D Requirements During Pregnancy
    Bruce Hollis; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  25. PTH (7-34) for Chemotherapy alopecia in Breast Cancer
    Michael Holick; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  26. THE PHOTOBIOLOGY OF VITAMIN D
    Michael Holick; Fiscal Year: 2005
    ..Results from this study should provide important new insights into the photoproduction of toxisterols and suprasterols in human skin and provide new information about their potential biologic functions in the skin. ..
  27. EFFECT OF POTASSIUM BICARBONATE ON BONE AND MUSCLE
    Bess Dawson Hughes; Fiscal Year: 2008
    ....
  28. NIH OSTEOPOROSIS & RELATED BONE DISEASES RESOURCE CENTER
    Bess Dawson Hughes; Fiscal Year: 2002
    ..Specific efforts include supporting the National Osteoporosis Data Group, collecting and disseminating definitive statistics on bone diseases and on conditions co-morbid with osteoporosis, and preparing summary reports. ..
  29. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  30. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  31. Estrogen regulation of osteoclastogenesis in older men
    Pamela Taxel; Fiscal Year: 2003
    ..abstract_text> ..
  32. CALCIUM AND VITAMIN D MALNUTRITION IN ELDERLY WOMEN
    Joan Lappe; Fiscal Year: 2003
    ..This is a valid method to determine compliance, far superior to the traditional pill counts, and thus a substantial aid to measure the anti-fracture efficacy of calcium alone or calcium plus vitamin D interventions. ..
  33. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  34. Genetics of Stress Induced Hypertension in Black Youth
    Yanbin Dong; Fiscal Year: 2009
    ..Understanding the connections between salt, stress and genetics will provide a fresh approach into evaluating risk factors for high blood pressure. ..
  35. Determination of RDA for Vitamin D in Caucasian and African American Women
    John Gallagher; Fiscal Year: 2009
    ..The results from this study will also help in designing future larger clinical trials of the effect of vitamin D on falls and fractures. ..
  36. Genetics and cardiovascular reactivity in young twins
    Yanbin Dong; Fiscal Year: 2005
    ....
  37. Dual Energy X-Ray Absorptiometer (QDR4500A)
    Frances Tylavsky; Fiscal Year: 2003
    ..It is within the existing structure and function of the GCRC that the administrative and scientific oversight of this DXA will be managed. ..
  38. DIET AND GENETIC INTERACTIONS IN PROSTATE CANCER
    Edward Giovannucci; Fiscal Year: 2001
    ..The buccal brushings, along with providing the basis for the specific aims in this application, will allow for the rapid testing of future specific hypotheses. ..
  39. Vitamin D Hormone Signaling in Bone Mineral Homeostasis
    Mark R Haussler; Fiscal Year: 2010
    ..new therapeutic strategies to prevent and treat osteoporosis with bone anabolic 1,25(OH)2D3 analogs, but could also shed light on the novel anticancer effects of vitamin D at sites such as the colon, skin, breast and ..
  40. OSTEOPOROTIC ORAL BONE QUANTIFICATION
    Charles Hildebolt; Fiscal Year: 2002
    ..It is anticipated that these PSP methods will result in better prevention, diagnosis and treatment of bone loss and will facilitate research aimed at establishing risk factors for alveolar bone loss. ..
  41. FUNCTION OF THE VITAMIN D RECEPTOR AND BONE DISEASE
    MARK HAUSSLER; Fiscal Year: 2002
    ....
  42. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2003
    ..abstract_text> ..
  43. Variation in the ALOX5 gene and response to omega-3 fatty acid supplements
    Charles Stephensen; Fiscal Year: 2007
    ..Indicators of cardiovascular risk will also be assessed before and after intervention, including blood lipid profile, blood pressure, heart rate, and plasma CRP, glucose and insulin concentrations. [unreadable] [unreadable] [unreadable]..
  44. DIFERENTIAL ACTIVATION OF THE VITAMIN D RECEPTOR
    Sara Peleg; Fiscal Year: 2003
    ..These studies will facilitate the development of selective vitamin D receptor modulators that may be useful for treatment of various clinical conditions, including osteoporosis, secondary hyperparathyroidism, and cancer. ..
  45. EXERCISE AND CALCIUM EFFECT ON PUBERTAL BONE GAIN
    Joan Lappe; Fiscal Year: 2006
    ..If these findings hold, they would provide strong support for the essential role of calcium in addition to exercise in maximizing bone mass in growing females. ..
  46. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  47. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  48. A comprehensive smoking index to model smoking history
    Thomas Dietrich; Fiscal Year: 2006
    ..Significance: The CSI may be an efficient way to capture different characteristics of smoking in a single variable to model smoking history in epidemiologic models of chronic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  49. Predictors of Living Kidney Donor Recruitment
    Peter Reese; Fiscal Year: 2006
    ..The primary outcome of successful recruitment will be registration of a potential donor at a transplant center for evaluation. [unreadable] [unreadable] [unreadable]..
  50. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..
  51. Calcium Foods and Bone Health of Adolescent Girls
    Joan Lappe; Fiscal Year: 2007
    ..Lack of a calcium effect would provide support for further research into other methods or concomitant methods of maximizing skeletal development. ..
  52. Vitamin A Regulates Th1/Th2 Development via RXR Pathway
    Charles Stephensen; Fiscal Year: 2007
    ..In addition, receptor-selective retinoids are currently used in cancer therapy and are being evaluated for diabetes. This work will help evaluate possible side effects of these therapies. ..
  53. 25-hydroxy-D3 as a possible chemopreventive agent for breast cancer
    Xinjian Peng; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. VITAMIN D METABOLISM THROUGH A RING MODIFICATION
    Satyanarayana Reddy; Fiscal Year: 2002
    ..abstract_text> ..
  55. Outcomes of Sleep Disorders in Older Men-Portland
    Eric Orwoll; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  56. NOVEL FUNCTIONS OF THE VITAMIN D RECEPTOR AND DISEASE
    MARK HAUSSLER; Fiscal Year: 2007
    ..abstract_text> ..
  57. ORAL AND SKELETAL BONE LOSS IN OLDER MEN
    Eric Orwoll; Fiscal Year: 2006
    ..Since the MrOS cohort is already established through other funds, this request will provide a very cost-effective means for addressing these important oral health issues. ..
  58. Bone-Active Treatments for Chronic Periodontitis
    Charles Hildebolt; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..