cholecalciferol

Summary

Summary: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.

Top Publications

  1. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
  2. ncbi Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 77:204-10. 2003
  3. ncbi Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial
    Kerrie M Sanders
    Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Victoria, Australia 3220
    JAMA 303:1815-22. 2010
  4. ncbi Vitamin D2 is much less effective than vitamin D3 in humans
    Laura A G Armas
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:5387-91. 2004
  5. pmc Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:677-81. 2008
  6. ncbi Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial
    Thomas Larsen
    Department of Medical Research, Holstebro Hospital, Holstebro, Denmark
    Am J Hypertens 25:1215-22. 2012
  7. pmc Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling
    H G Pálmer
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, E 28029 Madrid, Spain
    J Cell Biol 154:369-87. 2001
  8. ncbi Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level
    R Vieth
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 73:288-94. 2001
  9. ncbi Vitamin D(3) is more potent than vitamin D(2) in humans
    Robert P Heaney
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E447-52. 2011
  10. ncbi Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
    Rolf Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Nutr 48:349-54. 2009

Detail Information

Publications358 found, 100 shown here

  1. ncbi Overview of general physiologic features and functions of vitamin D
    Hector F DeLuca
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706 1544, USA
    Am J Clin Nutr 80:1689S-96S. 2004
    ..This overview provides a brief description of the physiologic, endocrinologic, and molecular biologic characteristics of vitamin D. It also provides information on new selective analogs of 1alpha,25-dihydroyvitamin D3 for therapy...
  2. ncbi Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
    Robert P Heaney
    Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 77:204-10. 2003
    The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin.
  3. ncbi Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial
    Kerrie M Sanders
    Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, Victoria, Australia 3220
    JAMA 303:1815-22. 2010
    ..Improving vitamin D status may be an important modifiable risk factor to reduce falls and fractures; however, adherence to daily supplementation is typically poor...
  4. ncbi Vitamin D2 is much less effective than vitamin D3 in humans
    Laura A G Armas
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:5387-91. 2004
    ..5:1. Vitamin D(2) potency is less than one third that of vitamin D(3). Physicians resorting to use of vitamin D(2) should be aware of its markedly lower potency and shorter duration of action relative to vitamin D(3)...
  5. pmc Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D
    Michael F Holick
    Department of Medicine, Boston University School of Medicine, 715 Albany Street, M 1013, Boston, Massachusetts 02118, USA
    J Clin Endocrinol Metab 93:677-81. 2008
    ..Two reports suggested that vitamin D2 is less effective than vitamin D3 in maintaining vitamin D status...
  6. ncbi Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial
    Thomas Larsen
    Department of Medical Research, Holstebro Hospital, Holstebro, Denmark
    Am J Hypertens 25:1215-22. 2012
    ..In people living at northern latitudes diminished cholecalciferol synthesis in the winter increases the risk of vitamin D deficiency...
  7. pmc Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling
    H G Pálmer
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, E 28029 Madrid, Spain
    J Cell Biol 154:369-87. 2001
    ..Our results show that 1alpha,25(OH)2D(3) induces E-cadherin and modulates beta-catenin-TCF-4 target genes in a manner opposite to that of beta-catenin, promoting the differentiation of colon carcinoma cells...
  8. ncbi Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level
    R Vieth
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Am J Clin Nutr 73:288-94. 2001
    ..The Food and Nutrition Board of the National Academy of Sciences states that 95 microg vitamin D/d is the lowest observed adverse effect level (LOAEL)...
  9. ncbi Vitamin D(3) is more potent than vitamin D(2) in humans
    Robert P Heaney
    Creighton University, 601 North 30th Street, Suite 4841, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 96:E447-52. 2011
    ..Current unitage for the calciferols suggests that equimolar quantities of vitamins D(2) (D2) and D(3) (D3) are biologically equivalent. Published studies yield mixed results...
  10. ncbi Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels
    Rolf Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Nutr 48:349-54. 2009
    ..Studies have suggested that vitamin D may be important for both insulin sensitivity and insulin secretion, and that supplementation with vitamin D may subsequently prevent development of type 2 diabetes...
  11. ncbi The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients
    A M Borissova
    Department of Endocrinology, University Hospital, 6 Damjan Gruev str, 1303 Sofia, Bulgaria
    Int J Clin Pract 57:258-61. 2003
    ..The diabetic patients were treated with cholecalciferol 1332 IU daily for one month. The mean plasma 25(OH)D level was 35.3 +/- 15...
  12. ncbi The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial
    M D Witham
    Ageing and Health, Ninewells Hospital, Dundee DD1 9SY, UK
    Diabetologia 53:2112-9. 2010
    ..We compared the effect of 100,000 and 200,000 IU doses of vitamin D(3) on endothelial function, blood pressure and markers of glycaemic control in patients with type 2 diabetes...
  13. pmc Efficacy and safety of a short course of very-high-dose cholecalciferol in hemodialysis
    Haimanot Wasse
    Division of Nephrology, Emory University, Atlanta, GA, USA
    Am J Clin Nutr 95:522-8. 2012
    ..Vitamin D deficiency is highly prevalent among hemodialysis patients, but little data exist in support of an optimal repletion regimen...
  14. ncbi Impact of cholecalciferol treatment on biomarkers of inflammation and myocardial structure in hemodialysis patients without hyperparathyroidism
    Sergio Bucharles
    Renal Division, Center for Health and Biological Sciences, Pontificia Universidade Catolica do Parana, Curitiba, Parana, Brazil
    J Ren Nutr 22:284-91. 2012
    ..The aim of this study was to evaluate the impact of cholecalciferol supplementation on biomarkers of mineral metabolism, inflammation, and cardiac function in a group of HD ..
  15. ncbi Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement
    Anna Mari Natri
    University of Helsinki, Department of Applied Chemistry and Microbiology, Finland
    J Nutr 136:123-7. 2006
    ..The bioavailability of cholecalciferol from bread is not known...
  16. ncbi A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness
    Yanbin Dong
    Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Clin Endocrinol Metab 95:4584-91. 2010
    ..Vitamin D insufficiency/deficiency is commonly observed in black youth...
  17. ncbi Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial
    Christian Wejse
    Infectious Disease Research Unit, Aarhus University Hospital, Skejby, Brendstrupgaardsvej, 8200 Aarhus N, Denmark
    Am J Respir Crit Care Med 179:843-50. 2009
    ..Vitamin D has been shown to be involved in the host immune response toward Mycobacterium tuberculosis...
  18. ncbi Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly
    Elisabetta Romagnoli
    Department of Clinical Sciences, University of Rome Sapienza, Viale del Policlinico 155, 00161 Rome, Italy
    J Clin Endocrinol Metab 93:3015-20. 2008
    In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status.
  19. ncbi Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects
    M Sneve
    Department of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway
    Eur J Endocrinol 159:675-84. 2008
    Investigate whether cholecalciferol supplementation leads to weight loss in overweight and obese adults.
  20. ncbi Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials
    Heike A Bischoff-Ferrari
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 293:2257-64. 2005
    ..The role and dose of oral vitamin D supplementation in nonvertebral fracture prevention have not been well established...
  21. ncbi High-dose oral vitamin D3 supplementation in the elderly
    C J Bacon
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Osteoporos Int 20:1407-15. 2009
    ..With baseline 25OHD > 50 nmol/L, vitamin D supplementation does not reduce PTH levels...
  22. pmc Cholecalciferol supplementation alters calcitriol-responsive monocyte proteins and decreases inflammatory cytokines in ESRD
    Jason R Stubbs
    3901 Rainbow Boulevard, MS 3002, Kansas City, KS 66160, USA
    J Am Soc Nephrol 21:353-61. 2010
    ..patients who had 25(OH)D insufficiency and were undergoing long-term hemodialysis and assessed changes after cholecalciferol and paricalcitol therapies in both vitamin D-responsive proteins in circulating monocytes and serum levels of ..
  23. ncbi Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects
    Julia Beilfuss
    Department of Gastroenterology, Medical Clinic, University Hospital of North Norway, 9038 Tromsø, Norway
    Cytokine 60:870-4. 2012
    ..We also proposed that the intervention with high dose of cholecalciferol may have effect on the cytokine levels and result in corresponding changes in the measures of insulin ..
  24. ncbi Cholecalciferol (vitamin D) differentially regulates antimicrobial peptide expression in bovine mammary epithelial cells: implications during Staphylococcus aureus internalization
    Ana Dolores Téllez-Pérez
    Centro Multidisciplinario de Estudios en Biotecnología, Universidad Michoacana de San Nicolas de Hidalgo, Km 9 5 Carretera Morelia Zinapécuaro Posta Veterinaria CP 58893, Morelia, Michoacan, Mexico
    Vet Microbiol 160:91-8. 2012
    ..The aim of this study was to determine the effect of cholecalciferol (vitamin D3) on S...
  25. pmc High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial
    Jessica A Alvarez
    Division of Endocrinology, Metabolism, and Lipids, Emory University School of Medicine, Atlanta, GA, USA
    Am J Clin Nutr 96:672-9. 2012
    ..Vitamin D deficiency contributes to secondary hyperparathyroidism, which occurs early in chronic kidney disease (CKD)...
  26. ncbi A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model
    Alessandro Fichera
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    J Surg Res 142:239-45. 2007
    ..Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells...
  27. pmc Cholecalciferol supplementation in hemodialysis patients: effects on mineral metabolism, inflammation, and cardiac dimension parameters
    Patrícia João Matias
    Hemodial Dialysis Unit, Quinta da Mina, Lote 3 r c, 2600 063 Vila Franca de Xira, Portugal
    Clin J Am Soc Nephrol 5:905-11. 2010
    ..The aim of this study was to evaluate the effects of oral cholecalciferol supplementation on mineral metabolism, inflammation, and cardiac dimension parameters in long-term ..
  28. ncbi Ergocalciferol and cholecalciferol in CKD
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am J Kidney Dis 60:139-56. 2012
    ..Based on the current state of the evidence, we provide suggestions for clinical practice and address areas of uncertainty that need further research...
  29. pmc Effects of cholecalciferol on functional, biochemical, vascular, and quality of life outcomes in hemodialysis patients
    Nathan A Hewitt
    Postgraduate Medical School, University of Notre Dame, Sydney, Australia
    Clin J Am Soc Nephrol 8:1143-9. 2013
    ..This randomized controlled trial examined effects of cholecalciferol supplementation in patients on hemodialysis.
  30. ncbi Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes mellitus
    Monica A L Gabbay
    Diabetes Center of Endocrinology Division, Department ofMedicine, Sao Paulo Federal University, Sao Paulo, SP, Brazil
    Arch Pediatr Adolesc Med 166:601-7. 2012
    ..the effect of vitamin D3 on cytokine levels, regulatory T cells, and residual β-cell function decline when cholecalciferol (vitamin D3 administered therapeutically) is given as adjunctive therapy with insulin in new-onset type 1 ..
  31. ncbi Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol
    Britta Diesel
    Institut fur Humangenetik, Theoretische Medizin, Universitat des Saarlandes, Saarbrucken, Germany
    Clin Cancer Res 11:5370-80. 2005
    ..A better understanding of the vitamin D(3) metabolism is required to evaluate its potential therapeutic value for cancers. Here, we set out to contribute to the understanding of vitamin D(3) metabolism in glioblastoma multiforme...
  32. ncbi Randomized controlled trial of cholecalciferol supplementation in chronic kidney disease patients with hypovitaminosis D
    Peter Marckmann
    Clinical Research Unit, Department of Nephrology, Odense University Hospital, Odense, Denmark
    Nephrol Dial Transplant 27:3523-31. 2012
    ..Hypovitaminosis D is common in chronic kidney disease (CKD). Effects of 25-hydroxyvitamin D replenishment in CKD are not well described...
  33. ncbi The ratio of serum 24,25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation
    Dennis Wagner
    Department of Nutritional Sciences, University of Toronto, Canada
    J Steroid Biochem Mol Biol 126:72-7. 2011
    ..The 24,25:25VD(3) ratio may therefore have clinical utility as a marker for VD(3) catabolism and a predictor of serum 25VD(3) response to VD(3) supplementation...
  34. ncbi Genistein aglycone effect on bone loss is not enhanced by supplemental calcium and vitamin D3: a dose ranging experimental study
    A Bitto
    Department of Clinical and Experimental Medicine and Pharmacology, Section of Pharmacology, University of Messina, Italy
    Phytomedicine 18:879-86. 2011
    ..This observation has implications regarding the use of calcium and vitamin D(3) supplementation...
  35. pmc Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes
    Erik Salum
    Department of Cardiology, University of Tartu, 8 Puusepa Street, Tartu, 51014, Estonia
    Cardiovasc Diabetol 11:58. 2012
    ..This study aimed to examine both the effects of diabetes on the functional/structural properties of the aorta and the endothelial function and the effects of vitamin D supplementation...
  36. ncbi No effect of supplementation with cholecalciferol on cytokines and markers of inflammation in overweight and obese subjects
    Rolf Jorde
    Institute of Clinical Medicine, University of Tromsø, Medical Clinic, University Hospital of North Norway, Tromsø, Norway
    Cytokine 50:175-80. 2010
    ..In conclusion, we were not able to demonstrate with certainty any significant relation between serum levels of 25(OH)D levels and a number of cytokines and markers of inflammation...
  37. ncbi Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards
    Reinhold Vieth
    Department of Nutritional Sciences, University of Toronto, Mount Sinai Hospital, Toronto, M5G 1L5, Canada
    J Nutr 136:1117-22. 2006
    ....
  38. pmc Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults
    Rachael M Biancuzzo
    Department of Medicine, Boston University School of Medicine, MA, USA
    Am J Clin Nutr 91:1621-6. 2010
    ..Vitamin D has been added to calcium-fortified orange juice. It is unknown whether vitamin D is as bioavailable from orange juice as it is from supplements...
  39. ncbi Cholecalciferol loading dose guideline for vitamin D-deficient adults
    Lenneke van Groningen
    Department of Internal Medicine, Rijnstate Hospital Arnhem, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands
    Eur J Endocrinol 162:805-11. 2010
    Severe vitamin D deficiency is very common. Evidence-based guidelines for rapid correction with high-dose oral cholecalciferol are not yet available.
  40. ncbi Vitamin D(3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats
    J Y Wang
    Department of Physiology, National Defense Medical Center, Taipei, Taiwan
    Brain Res 904:67-75. 2001
    ..Since both H(2)O(2) and 6-OHDA may injure cells via free radical and reactive oxygen species, the neuroprotection seen here may operate via a reversal of such a toxic mechanism...
  41. ncbi Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production
    Ai Leng Khoo
    Department of Laboratory Medicine, Laboratory Medical Immunology, Nijmegen, The Netherlands
    Cytokine 55:294-300. 2011
    ..These two effects may have beneficial consequences, by reducing the collateral tissue damage induced by proinflammatory cytokines, while the antibacterial effects of cathelicidin are enhanced...
  42. ncbi Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial
    Heike A Bischoff-Ferrari
    Centre on Aging and Mobility, University of Zurich, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland
    Arch Intern Med 170:813-20. 2010
    ..Care of elderly patients after hip fracture is not well established...
  43. ncbi Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial
    Bahareh Nikooyeh
    Laboratory of Nutrition Research, National Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
    Am J Clin Nutr 93:764-71. 2011
    ..Low serum concentrations of 25-hydroxyvitamin D [25(OH)D] have been associated with impaired glucose tolerance and diabetes...
  44. pmc Serum metabolite profiles and target tissue gene expression define the effect of cholecalciferol intake on calcium metabolism in rats and mice
    James C Fleet
    Department of Foods and Nutrition and the Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN 47907 2059, USA
    J Nutr 138:1114-20. 2008
    We studied the effect of cholecalciferol (VD3) intake on VD3 status and markers of calcium (Ca) homeostasis in mice and rats...
  45. ncbi Vitamin D3 confers protection from autoimmune encephalomyelitis only in female mice
    Karen M Spach
    Department of Nutritional Sciences, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 175:4119-26. 2005
    ....
  46. ncbi The case against ergocalciferol (vitamin D2) as a vitamin supplement
    Lisa A Houghton
    School of Nutrition and Dietetics, Acadia University, Wolfville, Canada
    Am J Clin Nutr 84:694-7. 2006
    Supplemental vitamin D is available in 2 distinct forms: ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3)...
  47. ncbi Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3
    Gerald J Atkins
    Department of Orthopaedics and Trauma, University of Adelaide, Adelaide, South Australia 5000, Australia
    Bone 40:1517-28. 2007
    ..Our results are therefore consistent with the reported benefits of maintaining a healthy vitamin D status in the elderly to reduce the risk of fractures...
  48. ncbi Serum 25-hydroxyvitamin D levels in vitamin D-insufficient hip fracture patients after supplementation with ergocalciferol and cholecalciferol
    Paul Glendenning
    Department of Core Clinical Pathology and Biochemistry, PathWest Royal Perth Hospital, Perth, Western Australia 6000, Australia
    Bone 45:870-5. 2009
    ..However, the equipotency of ergocalciferol and cholecalciferol supplementation in this patient group has not been studied in a randomized trial using high-performance ..
  49. pmc Macrophage-derived IL-1beta stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3
    P Kaler
    Department of Oncology, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, NY10467, USA
    Oncogene 28:3892-902. 2009
    ..Our data therefore established that vitamin D3 exerts its chemopreventive activity by interrupting a crosstalk between tumor epithelial cells and the tumor microenvironment...
  50. ncbi 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients
    Ava Masoumi
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095 7358, USA
    J Alzheimers Dis 17:703-17. 2009
    ..Human macrophages are a new paradigm for testing immune therapies for AD...
  51. pmc The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women
    D Lee Alekel
    Nutrition and Wellness Research Center, Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Am J Clin Nutr 91:218-30. 2010
    ..Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women...
  52. ncbi Vitamin D(3) attenuates cortical infarction induced by middle cerebral arterial ligation in rats
    Y Wang
    National Institute on Drug Abuse, NIH, Baltimore, MD, USA
    Neuropharmacology 39:873-80. 2000
    ..In conclusion, our data indicate that D3 reduces ischemia-induced brain damage and supports the hypothesis that this effect may be through the up-regulation of GDNF mechanisms in cortex...
  53. ncbi Prevention of rickets and vitamin D deficiency in infants, children, and adolescents
    Carol L Wagner
    American College of Obstetrics and Gynecology
    Pediatrics 122:1142-52. 2008
    ..New evidence supports a potential role for vitamin D in maintaining innate immunity and preventing diseases such as diabetes and cancer. The new data may eventually refine what constitutes vitamin D sufficiency or deficiency...
  54. ncbi The tolerability and biochemical effects of high-dose bolus vitamin D2 and D3 supplementation in patients with vitamin D insufficiency
    P Leventis
    Department of Rheumatology, St George s Healthcare NHS Trust, London, UK
    Scand J Rheumatol 38:149-53. 2009
    ..To investigate the practicality and tolerability of high-dose intramuscular (i.m.) vitamin D2 or oral vitamin D3 replacement in vitamin D-insufficient patients, and to evaluate the biochemical efficacy of each formulation...
  55. pmc Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children
    Joyce Maalouf
    Calcium Metabolism and Osteoporosis Program, American University of Beirut Medical Center, Bliss Street, Beirut, Lebanon
    J Clin Endocrinol Metab 93:2693-701. 2008
    ..Hypovitaminosis D is prevalent in youth worldwide, but the safety of vitamin D at doses exceeding 200 IU/d is unknown in this age group. We assessed the safety of high doses of vitamin D(3) administered to apparently healthy schoolchildren...
  56. ncbi Superiority of a high loading dose of cholecalciferol to correct hypovitaminosis d in patients with inflammatory/autoimmune rheumatic diseases
    Pier Paolo Sainaghi
    Internal Medicine and Rheumatology Unit, Department of Translational Medicine, Università del Piemonte Orientale A Avogadro and AOU Maggiore della Carità and the Interdisciplinary Research Center of Autoimmune Diseases IRCAD, Novara, Italy
    J Rheumatol 40:166-72. 2013
    To compare 3 different cholecalciferol supplementation regimens in patients with rheumatic diseases.
  57. ncbi Determination of optimal cholecalciferol treatment in renal transplant recipients using a population pharmacokinetic approach
    Sihem Benaboud
    EA3620, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    Eur J Clin Pharmacol 69:499-506. 2013
    No information on optimal cholecalciferol dosing in kidney transplant patients is currently available because the time-course of serum 25-hydroxy vitamin D [25(OH)D] concentration has never been investigated...
  58. ncbi Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B
    Catherine M Fisk
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College, Waterloo Campus, London, UK
    J Nutr 142:1286-90. 2012
    Uncertainty remains regarding the efficacy of low intakes of ergocalciferol (vitamin D2 or D2) and cholecalciferol (vitamin D3 or D3) provided in food to increase serum 25-hydroxy-vitamin D (25-OH-D) metabolite concentrations when UV-B ..
  59. pmc Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial
    Daksha P Trivedi
    Clinical Gerontology Unit, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge CB2 2QQ
    BMJ 326:469. 2003
    ..To determine the effect of four monthly vitamin D supplementation on the rate of fractures in men and women aged 65 years and over living in the community...
  60. ncbi Monthly cholecalciferol administration in haemodialysis patients: a simple and efficient strategy for vitamin D supplementation
    Guillaume Jean
    Centre de Rein Artificiel, 42 Avenue du 8 Mai 1945, 69160, Tassin Demi lune, France
    Nephrol Dial Transplant 24:3799-805. 2009
    ..Objective. The aim was to assess the long-term efficiency and safety of a monthly oral dose of cholecalciferol (100 000 IU) in vitamin D-deficient haemodialysis (HD) patients.
  61. pmc The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets
    Tom D Thacher
    Department of Family Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 94:3314-21. 2009
    ..Children with calcium-deficiency rickets have high 1,25-dihydroxyvitamin D values...
  62. ncbi Changes in body composition following a dietary and lifestyle intervention trial: the postmenopausal health study
    Yannis Manios
    Department of Nutrition and Dietetics, Harokopio University, 70, El Venizelou Ave, 176 71 Kallithea, Athens, Greece
    Maturitas 62:58-65. 2009
    ....
  63. ncbi Vitamin D poisoning by table sugar
    Reinhold Vieth
    Department of Laboratory Medicine and Pathobiology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada MG5 1X5
    Lancet 359:672. 2002
  64. ncbi No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year
    R Jorde
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    J Intern Med 267:462-72. 2010
    ..Cross-sectional studies indicate vitamin D to be of importance for glucose tolerance, blood pressure and serum lipids, but whether supplementation with vitamin D would improve cardio-vascular risk factors is not known...
  65. pmc Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease
    J A Alvarez
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Eur J Clin Nutr 67:264-9. 2013
    Vitamin D has anti-inflammatory and immune-regulating properties. We aimed to determine if high-dose cholecalciferol supplementation for 1 year in subjects with early chronic kidney disease (CKD) improved circulating markers of ..
  66. pmc The effect of calcium plus vitamin D on risk for invasive cancer: results of the Women's Health Initiative (WHI) calcium plus vitamin D randomized clinical trial
    Robert L Brunner
    Department of Family and Community Medicine, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Nutr Cancer 63:827-41. 2011
    ..The interactions are only suggestive given multiple testing considerations. The low vitamin D dose provided, limited adherence, and lack of serum 25(OH)D values should be considered when interpreting these findings...
  67. ncbi High-dose cholecalciferol to correct vitamin D deficiency in haemodialysis patients
    Faruk Tokmak
    Department of Nephrology, Marienhospital Herne, Ruhr University, Bochum, Germany
    Nephrol Dial Transplant 23:4016-20. 2008
    ..Non-activated vitamin D may also have beneficial effects on bone, cardiovascular and immune functions. Cholecalciferol is the prevalent non-activated vitamin D in Europe, but there is no valid prospective data available about ..
  68. pmc Actions of vitamin D are mediated by the TLR4 pathway in inflammation-induced colon cancer
    G Murillo
    Division of Carcinogenesis and Chemoprevention, IIT Research Institute, Chicago, IL 60616, USA
    J Steroid Biochem Mol Biol 121:403-7. 2010
    ..Recently, less active vitamin D metabolites, cholecalciferol and 25-hydroxyvitamin D (25(OH)D), have gained considerable attention as promising agents against IBD-related ..
  69. ncbi Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity
    Ikuo Imazeki
    Division of Immunoregulation, Institute for Genetic Medicine, Hokkaido University, Sapparo, Japan
    Biomed Res 27:1-9. 2006
    ..Thus, VitD3 derivatives are demonstrated to inhibit the functional differentiation of DC1, Tc1 and Th1 cells, which play a critical role in type-1 cellular immune responses...
  70. pmc Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis
    Samantha Kimball
    Departments of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:2826-34. 2011
    ..The active metabolite of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], is a potent modulator of immune cells in vitro...
  71. pmc VITA-D: cholecalciferol substitution in vitamin D deficient kidney transplant recipients: a randomized, placebo-controlled study to evaluate the post-transplant outcome
    Ursula Thiem
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Trials 10:36. 2009
    ..As such, vitamin D is thought to exert beneficial effects within the transplant setting, especially in kidney transplant recipients, considering the high prevalence of vitamin D deficiency in kidney transplant recipients...
  72. ncbi Dietary vitamin D3 supplementation at 10× the adequate intake improves functional capacity in the G93A transgenic mouse model of ALS, a pilot study
    Alexandro Gianforcaro
    School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
    CNS Neurosci Ther 18:547-57. 2012
    ..Vitamin D has antioxidant, anti-inflammatory, and neuroprotective properties, and may mitigate amyotrophic lateral sclerosis (ALS) pathology...
  73. pmc Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative
    JoAnn E Manson
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 17:683-91. 2010
    ..We compared CAC scores after trial completion between women randomized to calcium/vitamin D supplementation and women randomized to placebo...
  74. ncbi Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin-angiotensin-aldosterone system inhibition
    Min Jeong Kim
    Imperial College Kidney and Transplant Institute, Hammersmith Hospital, Imperial College London, London, UK
    Kidney Int 80:851-60. 2011
    ..a 7-month period, 63 patients were enrolled and those with low levels of 25(OH)D were treated with oral cholecalciferol for 4 months...
  75. pmc Vitamin D, insulin secretion, sensitivity, and lipids: results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique
    Guri Grimnes
    Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Diabetes 60:2748-57. 2011
    ....
  76. ncbi Effect of cholecalciferol and calcium supplementation on muscle strength and energy metabolism in vitamin D-deficient Asian Indians: a randomized, controlled trial
    Rajat Gupta
    Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India
    Clin Endocrinol (Oxf) 73:445-51. 2010
    ..Vitamin D deficiency is prevalent worldwide. Vitamin D supplementation has shown variable effect on skeletal muscle strength in the elderly with hypovitaminosis D. There is a paucity of similar data in young individuals...
  77. pmc Vitamin D3 deficiency differentially affects functional and disease outcomes in the G93A mouse model of amyotrophic lateral sclerosis
    Jesse A Solomon
    School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada
    PLoS ONE 6:e29354. 2011
    ..We have previously demonstrated that vitamin D(3) supplementation at 10× the adequate intake improves functional outcomes in a mouse model of ALS...
  78. pmc Dietary vitamin D3 supplements reduce demyelination in the cuprizone model
    Stig Wergeland
    Department of Neurology, Norwegian Multiple Sclerosis Competence Centre, Haukeland University Hospital, Bergen, Norway
    PLoS ONE 6:e26262. 2011
    ..In conclusion, high dietary doses of vitamin D3 reduce the extent of demyelination, and attenuate microglia activation and macrophage infiltration in a toxic model of demyelination, independent of lymphocyte infiltration...
  79. ncbi Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer's disease
    C Oudshoorn
    Department of Internal Medicine, Section of Geriatric Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:539-43. 2008
    ..Recent studies suggest that vitamin D metabolites may be important for preserving cognitive function via specific neuroprotective effects. No large studies have examined the association between vitamin D status and cognition...
  80. pmc Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: a randomized, double-blind, placebo-controlled pilot study
    Karin Amrein
    Medical University of Graz, Department of Internal Medicine, Division of Endocrinology and Metabolism, Auenbruggerplatz 15, 8036 Graz, Austria
    Crit Care 15:R104. 2011
    ..The objective of this trial was to evaluate the safety and efficacy of a single oral high-dose vitamin D3 supplementation in an intensive care setting over a one-week observation period...
  81. pmc 1α,25-dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3
    Vanessa Morales-Tirado
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Immunol 138:212-21. 2011
    ..The enhanced suppressive capacity is likely due to vitamin D3's ability to uniquely modulate cell cycle progression and elevate FOXP3 expression. These data suggest a role for vitamin D3 as a mechanism for catalyzing potency of nTregs...
  82. pmc Evaluation of ergocalciferol or cholecalciferol dosing, 1,600 IU daily or 50,000 IU monthly in older adults
    N Binkley
    Osteoporosis Clinical Center and Research Program, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Clin Endocrinol Metab 96:981-8. 2011
    Whether ergocalciferol (D(2)) and cholecalciferol (D(3)) are equally effective to increase and maintain serum 25-hydroxyvitamin D [25(OH)D] concentration is controversial.
  83. ncbi Comparative effects of a novel plant-based calcium supplement with two common calcium salts on proliferation and mineralization in human osteoblast cells
    Ram Sudheer Adluri
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, CT, USA
    Mol Cell Biochem 340:73-80. 2010
    ..These findings suggest that AC may serve as a superior calcium supplement as compared to other calcium salts tested in the present study. Hence, AC may be developed as a novel anti-osteoporotic supplement in the near future...
  84. ncbi C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation
    Maya Kamao
    Department of Hygienic Sciences, Kobe Pharmaceutical University, Kobe 658 8558, Japan
    J Biol Chem 279:15897-907. 2004
    ..These results indicate that C-3 epimerization may be a common metabolic pathway for the major metabolites of vitamin D3...
  85. ncbi 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions
    Robert P Heaney
    Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA
    Am J Clin Nutr 87:1738-42. 2008
    ..Neither the efficiency of the 25-hydroxylation of vitamin D nor the steady state relation between vitamin D(3) and 25-hydroxyvitamin D [25(OH)D] has been studied in humans...
  86. ncbi High-dose oral vitamin D3 supplementation in rheumatology patients with severe vitamin D3 deficiency
    Cord von Restorff
    Triemli Hospital, Zurich, Switzerland
    Bone 45:747-9. 2009
    ..The aim of this report is to describe changes of 25-hydroxyvitamin D (25(OH)D) serum concentrations achieved with a single oral dose of 300000 IU vitamin D3...
  87. ncbi Pharmacokinetics of a single, large dose of cholecalciferol
    Marium Ilahi
    Creighton University Medical Center, Omaha, NE 68131, USA
    Am J Clin Nutr 87:688-91. 2008
    ..There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence...
  88. ncbi Distinctive dendritic cell modulation by vitamin D(3) and glucocorticoid pathways
    Nianzeng Xing
    Department of Internal Medicine, Division of Nephrology, Mayo Clinic and Foundation, Transplant Center, Charlton Building 10A, 200 First Street, Rochester, MN 55905, USA
    Biochem Biophys Res Commun 297:645-52. 2002
    ..Additive inhibition was most striking for RANTES, CCR5, CCR7, and Rel B. The combined effects of the two hormonal pathways on DCs have unique immunomodulatory potential...
  89. ncbi Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs
    M D Griffin
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Biochem Biophys Res Commun 270:701-8. 2000
    ..Inhibition of DC maturation and stimulatory function was absent in cultures from mice genetically lacking vitamin D receptors (VDR). Vitamin D analogs effectively reduce DC function via VDR-dependent pathways...
  90. ncbi Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients
    Sophia Ish-Shalom
    Metabolic Bone Diseases Unit, Rambam Health Care Campus, Haifa, Israel
    J Clin Endocrinol Metab 93:3430-5. 2008
    ..Different dosing protocols have been used for vitamin D supplementation, but there has been a lack of comparative data among them...
  91. ncbi Vitamin D insufficiency and treatment with oral vitamin D3 in northern-dwelling patients with chronic kidney disease
    Diana Rucker
    Department of Medicine, Division of General Internal Medicine, University of Alberta, University of Alberta Hospital, Edmonton, Alberta, Canada
    J Nephrol 22:75-82. 2009
    ..We studied persons with both of these risk factors to determine the prevalence of vitamin D insufficiency and whether serum 25-hydroxyvitamin D (25(OH)D) levels were affected by oral vitamin D3 supplementation...
  92. ncbi Immunomodulatory effects of vitamin D on monocyte-derived dendritic cells in multiple sclerosis
    Halina Bartosik-Psujek
    Department of Neurology, Medical University of Lublin, Jaczewskiego 8, 20 090 Lublin, Poland
    Mult Scler 16:1513-6. 2010
    ..Moreover, inhibits the secretion of IL 23/12p40 and increases the secretion of CCL2. The data suggest that one of the mechanisms of the beneficial action of vitamin D3 in multiple sclerosis may be associated with its influence on DCs...
  93. ncbi Partial rescue of the phenotype in 1α-hydroxylase gene knockout mice by vitamin D3 injection
    Zeng Li Zhang
    Department of Toxicology, School of Radiation Medicine and Public Health, Soochow University, Suzhou, China
    Endocr Res 36:101-8. 2011
    ..To investigate whether 25-hydroxyvitamin D [25(OH)D] can mediate effects without being converted to 1α,25-dihydroxyvitamin D [1,25(OH)2D]...
  94. ncbi Cholecalciferol and 25-hydroxycholecalciferol content of chicken egg yolk as affected by the cholecalciferol content of feed
    P Mattila
    Agricultural Research Centre of Finland, FIN 316 000, Jokioinen, Finland
    J Agric Food Chem 47:4089-92. 1999
    The predominant source of vitamin D is the synthesis of cholecalciferol in the skin by the action of sunlight; however, due to the relative lack of sunlight, the intake of vitamin D from food is emphasized during winter, especially in ..
  95. ncbi The relative influence of calcium intake and vitamin D status on serum parathyroid hormone and bone turnover biomarkers in a double-blind, placebo-controlled parallel group, longitudinal factorial design
    John Aloia
    Bone Mineral Research Center, Winthrop University Hospital, Mineola, NY 11501, USA
    J Clin Endocrinol Metab 95:3216-24. 2010
    ..Adequate calcium and vitamin D are needed to maintain calcium balance...
  96. ncbi 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
    Jillanne Brown
    School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Neurosci Lett 343:139-43. 2003
    ..The role of vitamin D(3) during brain development warrants closer scrutiny...
  97. pmc Body size and serum 25 hydroxy vitamin D response to oral supplements in healthy older adults
    Miriam Blum
    Bone Metabolism Laboratory, Jean Mayer USDA, HNRC on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    J Am Coll Nutr 27:274-9. 2008
    ..Since vitamin D insufficiency is readily amenable to supplementation, it is important to understand what factors are associated with serum 25 hydroxy vitamin D (25(OH)D) response to vitamin D supplementation...
  98. ncbi Effect of cholecalciferol on parathyroid hormone and vitamin D levels in chronic kidney disease
    T Basturk
    Department of Nephrology, Bagcilar Research and Education Hospital, Istanbul, Turkey
    Minerva Urol Nefrol 63:287-92. 2011
    ..We aimed to determine the effect of a monthly oral vitamin D on the serum 25-hydroxyvitamin D levels and iPTH levels in patients with CKD...
  99. ncbi Hypovitaminosis D and response to cholecalciferol supplementation in patients with autoimmune and non-autoimmune rheumatic diseases
    Pier Paolo Sainaghi
    Immuno Rheumatology Unit, DMCS Università del Piemonte Orientale A Avogadro and AOU Maggiore della Carità, Novara, Italy
    Rheumatol Int 32:3365-72. 2012
    ..6) and older age (F:5.3), but not ARD, predicted plasma 25(OH)vitamin D <75 nmol/l. Cholecalciferol supplementation increased 25(OH)vitamin D plasma concentration equally in both ARD and NARD; however, only 29/..
  100. ncbi The effect of a single dose versus a daily dose of cholecalciferol on the serum 25-hydroxycholecalciferol and parathyroid hormone levels in the elderly with secondary hyperparathyroidism living in a low-income housing unit
    Melissa O Premaor
    Furlanetto Serviço de Emergência, Internal Medicine Division, Hospital de Clínicas in Porto Alegre HCPA, Rua Ramiro Barcelos 2350, Porto Alegre, Brazil
    J Bone Miner Metab 26:603-8. 2008
    ..a randomized, double-blind, controlled clinical trial to compare the effect of two regimens for administering cholecalciferol on the serum 25-hydroxycholecalciferol [25(OH)D] levels and in the reversion of secondary hyperparathyroidism ..
  101. ncbi Dietary cholecalciferol regulates the recruitment and growth of skeletal muscle fibers and the expressions of myogenic regulatory factors and the myosin heavy chain in European sea bass larvae
    Hélène Alami-Durante
    INRA, UR 1067 Nutrition Métabolisme Aquaculture, Saint Pée sur Nivelle, France
    J Nutr 141:2146-51. 2011
    The aim of this study was to determine whether dietary cholecalciferol affects the recruitment and growth of axial skeletal muscle fibers in first-feeding European sea bass. Larvae were fed diets containing 0.28 (VD-L, low dose), 0...

Research Grants72

  1. Vitamin D3, Interference with Androgen Signal and Inhibition of Prostate Cancer
    Bandana Chatterjee; Fiscal Year: 2013
    ..Information gleaned from our research may open up new strategies for prevention and clinical management of prostate cancer. ..
  2. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..The results of the studies will advance our knowledge on how vitamin D can be used as a therapeutic agent to improve inflammation in humans. ..
  3. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..In a 2x2 factorial design, participants will be randomized to moderate-to-high dose vitamin D3 (cholecalciferol;1600 IU [40 5g]/d) and fish oil (EPA [500 mg/d] + DHA [500 mg/d]) supplements (or placebos) independently...
  4. Vitamin D3 Regulation of the Hypothalamic-Pituitary-Gonadal Axis
    Genevieve S Neal-Perry; Fiscal Year: 2012
    ....
  5. Dietary Risk for Colon Cancer in the Mouse
    Leonard H Augenlicht; Fiscal Year: 2013
    ..abstract_text> ..
  6. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements to ..
  7. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..Trial (VITAL) (U01 CA138962), an ongoing, randomized, double-blind, placebo-controlled trial of vitamin D3 (cholecalciferol, 2000 IU/d) and/or marine omega-3 fatty acids (1 gm/d) in 20,000 men and women, to test the effects of ..
  8. Vitamin D and Arterial Function in Patients with Chronic Kidney Disease
    Jessica B Kendrick; Fiscal Year: 2013
    ..vitamin D insufficiency or deficiency will result in improved vascular endothelial function as compared to cholecalciferol supplementation...
  9. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..the context of an ongoing double-blind randomized controlled trial (RCT), the effect of oral vitamin D3 (cholecalciferol) supplementation (2000 IU daily) vs...
  10. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ....
  11. Community Ambulation Following Hip Fracture
    Jay Magaziner; Fiscal Year: 2013
    ..This study will evaluate a 16-week multi-component exercise program provided to patients in their homes to determine if it is effective in improving the ability to walk independently in the community (i.e., community ambulation). ..
  12. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..abstract_text> ..
  13. Vitamin D Deficiency in Glomerular Disease
    Michelle Denburg; Fiscal Year: 2013
    ..of 450 participants in the NIH-funded Nephrotic Syndrome Study Network (NEPTUNE) and (2) a pilot study of cholecalciferol supplementation in 35 children and young adults with FSGS...
  14. Clinical Trial of Vitamin D3 to Reduce Cancer Risk in Postmenopausal Women
    Joan Lappe; Fiscal Year: 2013
    ..Positive findings will provide support for health policy changes to promote optimal vitamin D levels in the population. ..
  15. Randomized trial of active vitamin D, cholecalciferol and placebo for CKD-MBD
    Sharon M Moe; Fiscal Year: 2011
    ..However, it is now known that there is vitamin D conversion outside the kidneys and that cholecalciferol may have direct effects on the target tissues bone and parathyroid gland...
  16. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..study, a large, randomized, double-blind, placebo-controlled trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and/or marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements, to ..
  17. Vitamin D Inhibition of HIV and M. Tuberculosis Coinfection in Macrophages
    Stephen A Spector; Fiscal Year: 2010
    ....
  18. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): We propose a randomized, placebo-controlled clinical trial of vitamin D3 (cholecalciferol) and omega-3 fatty acids (eicosapentaenoic acid plus docosahexaenoic acid) to prevent the development and ..
  19. A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
    Jae H Kang; Fiscal Year: 2013
    ..cost-effective randomized double-blind placebo-controlled 2x2 factorial trial of vitamin D (vitamin D3 [cholecalciferol], 2000 IU/day) and marine omega-3 fatty acid (docosahexaenoic acid + eicosapentaenoic acid, 1000 mg/day) ..
  20. Targeting induction of calcium buffer proteins for treatment of viral encephaliti
    John D Morrey; Fiscal Year: 2013
    ..This project could provide new avenues of basic research for WNV and JEV neuro- pathogenesis, and enhance clinical practice for the management of WNV, JEV, and viral encephalitis in general. ..
  21. Supplemental Vitamin D and Functional Outcomes in Early Adolescence
    Richard D Lewis; Fiscal Year: 2010
    ..The findings from this study have important pubiic health implications with respect to vitamin D intake recommendations aimed at improving the health of US children. ..
  22. Biological and Environmental modifiers of Vitamin D3 and Prostate Cancer Risk
    RICK ANTONIUS KITTLES; Fiscal Year: 2013
    ..More importantly, given that UVR and diet are general environmental exposures that can be easily modified, understanding their impact may have broad health implications. ..
  23. Calcium/Vitamin D, Biomarkers & Colon Polyp Prevention
    Roberd Bostick; Fiscal Year: 2009
    ..abstract_text> ..
  24. VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ....
  25. Disruption of Neural Stem Cell Homeostasis by Cytomegalovirus
    DEBORAH HYE SPECTOR; Fiscal Year: 2013
    ....
  26. The role of tolerogenic dendritic cells in islet-cell allograft transplantation
    SHERRIE JILL DIVITO; Fiscal Year: 2010
    ..Therefore, the development of cellular based therapies that prolong islet-cell transplant survival by inducing donor-specific tolerance without side effects is clearly advantageous. ..
  27. The effects of 1,25(OH)2D3 on the tumorigenesis of lung squamous cell carcinoma
    SARAH ANNE MAZZILLI; Fiscal Year: 2012
    ..The overall goal of the project is to determine the preventive effects of vitamin D on lung SCC. ..
  28. SLOS and Neuronal Oxidative Stress
    NED ALLEN PORTER; Fiscal Year: 2013
    ....
  29. Nutritional Intervention for Age-Related Muscular Function and Strength Losses
    John A Rathmacher; Fiscal Year: 2010
    ..Moreover, based upon the incidence of widespread Vitamin D deficiency in all ages, we anticipate the younger population will also benefit from similar supplementation. ..
  30. ISU Vet-LIRN Collaborative Validation of Testing Methods on Animal Diagnostic Spe
    WILSON KIIZA RUMBEIHA; Fiscal Year: 2013
    ..lab has a unique expertise in including aflatoxins, Ractopamine, ionophores, ergot alkaloids, bromethalin, Cholecalciferol, selenium, coumesterol, zearalenone and cyanotoxins...
  31. Chemoprevention of basal cell carcinoma with vitamin D
    Jean Y Tang; Fiscal Year: 2012
    ..Our goal is to determine whether vitamin D is an effective and safe agent to prevent basal cell carcinomas. ..
  32. VITamin D and omegA-3 triaL (VITAL)
    JOANN ELISABETH MANSON; Fiscal Year: 2013
    ..randomized, double-blind, placebo-controlled, 2x2 factorial trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements in the ..
  33. Breast Adipose Participates to Bioactivate Vitamin D and Inhibit Breast Cancer
    Glendon M Zinser; Fiscal Year: 2010
    ..The proposed studies are of an important and under- investigated area of mammary gland biology that may serve as a nutritional preventative and/or therapeutic option to fight breast cancer. ..
  34. HIGH-DOSE VITAMIN D AND ANTIMICROBIAL PEPTIDE EXPRESSION IN LUNG FAILURE
    Thomas R Ziegler; Fiscal Year: 2012
    ....
  35. Vitamin D induction of antibacterial activity in gingival cells
    Gill Diamond; Fiscal Year: 2009
    ..This proposal seeks to examine whether we can develop more in-depth studies of the potential for using vitamin D as a preventative treatment for periodontal disease. ..
  36. Diabetes Prevention in the Vitamin D and Omega-3 Trial
    Yiqing Song; Fiscal Year: 2013
    ....
  37. Can the Sunshine Vitamin Improve Mood and Self-Management in Women with Diabetes?
    Sue M Penckofer; Fiscal Year: 2013
    ..Thus, the potential for using this therapy is highly significant fr women with type 2 diabetes and other chronic populations who suffer from symptoms of depression which significantly impacts the self-management of their health. ..
  38. Regulation and Function of Immunoglobulin D in Mucosal Immune Defense
    Andrea Cerutti; Fiscal Year: 2013
    ..It will also support the use of vitamin D modifying regimens in treating immunopathologies and establish that more effective vaccination strategies against respiratory pathogens should actively boost IgD responses. ..
  39. Vitamin D and Osteoporosis Prevention in Elderly African Americans
    John F Aloia; Fiscal Year: 2013
    ....
  40. Impact of Vitamin D on Diabetic Kidney Disease in African Americans
    VANESSA ASTRUD DIAZ; Fiscal Year: 2012
    ..This project is an attempt to determine the impact of vitamin D supplementation on the progression of early stage diabetic kidney disease. ..
  41. Vitamin D and Immunosenescence in Older Long-Term Care Residents
    Adit A Ginde; Fiscal Year: 2013
    ..Ginde become a leading investigator of interventions to improve immunosenescence and reduce the burden of infection in older adults. ..
  42. Effects of vitamin D and omega-3 fatty acids on infectious diseases and hCAP18
    Carlos A Camargo; Fiscal Year: 2013
    ..The findings may have direct clinical and public health impact for the prevention of infections in older adults. ..
  43. Vitamin D Intervention and Atherosclerosis Progression in African American Women
    Howard N Hodis; Fiscal Year: 2013
    ..This ancillary study provides the opportunity to cost-effectively address whether vitamin D supplementation reduces the progression of atherosclerosis, specifically in an understudied unique cohort of elderly African American women. ..
  44. VITAL-AMD: Prevention of AMD in the VITamin D and OmegA-3 Trial
    Debra A Schaumberg; Fiscal Year: 2013
    ..a randomized, double-blind, placebo-controlled, 2x2 factorial trial designed to test vitamin D (vitamin D3 [cholecalciferol], 2000 IU/d) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], 1 g/d) ..
  45. Genetic Variants Influencing Response to Vitamin D in Colorectal Chemoprevention
    Elizabeth L Barry; Fiscal Year: 2012
    ..The public health significance of this work is substantial due to the prevalence of vitamin D insufficiency and the high incidence of colorectal cancer, osteoporosis, and other common diseases associated with poor vitamin D status. ..
  46. Novel Biosynthethic Pathway for Secosteroids and the Skin
    Andrzej T Slominski; Fiscal Year: 2013
    ..These are necessary for further development in Phase I clinical trials in patients with scleroderma or other fibrosing diseases, which represents our ultimate goal (clinical application). ..
  47. Vitamin D3 Supplementation for Low-Risk Prostate Cancer: A Randomized Trial
    Sebastiano Gattoni-Celli; Fiscal Year: 2013
    ..3) To analyze changes in the serum levels of cholecalciferol, 25(OH)D, 1,25(OH)2D, and prostate-specific antigen (PSA) at baseline and at the end of the study, and to ..
  48. Radiosensitization of Breast Cancer Cells by Vitamin D3 and Vitamin D Analogs
    Eden Wilson; Fiscal Year: 2012
    ....
  49. Vitamin D3 Metabolism and Colorectal Cancer: Correlating Phenotype to Genotype
    Josephia R Muindi; Fiscal Year: 2011
    ..tested in the two specific aims below using blood samples from two CRC patient cohorts (non intervention and cholecalciferol intervention of colorectal cancer patients)...
  50. Omega-3 Fatty Acids for Prevention of Dry Eye Disease: VITAL-DED
    Debra A Schaumberg; Fiscal Year: 2013
    ..to test marine omega-3 FA (465 mg/d eicosapentaenoic acid + 375 mg/d docosahexaenoic acid) and vitamin D3 (cholecalciferol, 2000 IU/d) supplements in the primary prevention of cancer and cardiovascular disease among 20,000 men and ..
  51. Vitamin D3 Effects on Musculoskeletal Symptoms with Use of Aromatase Inhibitors
    Alice C Shapiro; Fiscal Year: 2012
    ....
  52. ROLE OF CYP24 IN NON-SMALL CELL LUNG CANCER
    Pamela A Hershberger; Fiscal Year: 2013
    ..The therapeutic implication of this paradigm, once confirmed, is that agents that inhibit CYP24 can be used to restore vitamin D3-mediated growth control in NSCLC. ..
  53. Ph 2 Study of Vitamin D for Tx of Respiratory Complications in Sickle Cell Ds
    Margaret T Lee; Fiscal Year: 2013
    ..function, airway hyperreactivity and airway inflammation;and (3) to examine the effects of monthly oral vitamin D3 on immune function, using measures of T-cell effector and regulatory function and of systemic inflammation ..
  54. Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and Hypertension
    Howard D Sesso; Fiscal Year: 2013
    ..double-blind, placebo-controlled, 2x2 factorial trial, will test 2000 IU/day of vitamin D (as vitamin D3 [cholecalciferol]) and 1 g/day of marine I-3 FA (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements on ..
  55. Optimizing Vitamin D Treatment in HIV/AIDS: An RCT
    DOUGLAS THOMAS DIETERICH; Fiscal Year: 2013
    ..This information is essential for designing definitive multicenter trials in the future. ..
  56. Vitamin D and Periodontal Disease
    Gill Diamond; Fiscal Year: 2013
    ....
  57. Cellular Efflux and Metabolism of Protease Inhibitors
    Ashim Mitra; Fiscal Year: 2004
    ..The brain parenchymal and alveolar lining - two sanctuary sites that are 'protected' from optimal antiretroviral drug access. 4) to study the effect of protein binding on the influx and efflux of model compounds, and anti-HIV drugs. ..
  58. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..In our laboratory we synthesized a novel vitamin D analog, 1a-hydroxy-24-ethyl-cholecalciferol [1cc(OH)D5]...
  59. Dietary modulation of mammary tumorigenesis in the PymT model
    Lidija Klampfer; Fiscal Year: 2012
    ....
  60. Vitamin D3 Inhibition of Hedgehog Signaling and Cancer Chemoprevention
    ERVIN HAROLD EPSTEIN; Fiscal Year: 2013
    ..Thus there is urgent need for further investigation into the relation of vitamin D3 to cancer risk. ..
  61. Dendritic Cell-Targeting Microparticles for Subcellularly-Targeted Delivery of In
    BENJAMIN GEORGE KESELOWSKY; Fiscal Year: 2013
    ..This novel and innovative approach holds promise for correcting autoimmune responses in T1D and represents a simple, clinically translatable system. ..
  62. Vitamin D3 alters stromal-epithelial inflammatory crosstalk in human prostate
    Larisa Nonn; Fiscal Year: 2013
    ..trial (N=60, completed at the University of Toronto) wre given 400IU, 10,000IU or 40,000IU of vitamin D3 (cholecalciferol) for 4-6 weeks prior to radical prostatectomy...
  63. GROWTH AND DIFFERENTIATION OF HUMAN MAST CELLS
    ROBERT BRESSLER; Fiscal Year: 1993
    ..A greater understanding of these important aspects of mast cell biology will offer important insights into the pathophysiology of mast cell-related diseases...
  64. d-Penicillamine Chelation in lead-poisoned Children - A Phase ll/lll Trial
    Michael Shannon; Fiscal Year: 2007
    ..consequences of lead poisoning include impairment of heme synthesis, reduction in I-hydroxylation of 25(OH)-cholecalciferol (the Vitamin D precursor) and renal injury that results in microproteniuria, an increased risk of ..
  65. OSTEOPOROSIS/DIHYDROXYVITAMIN REGULATED GENE EXPRESSION
    Sylvia Christakos; Fiscal Year: 1993
    ..These studies could lead to future investigations concerning genetic manipulation of calcium responsiveness during aging. ..
  66. 1,25 DIHYDROXY VITAMIN D3 AND CELLULAR IMMUNITY
    Stavros Manolagas; Fiscal Year: 1991
    ....
  67. The pigmentary system: securing a place in the sun
    Andrzej Slominski; Fiscal Year: 2009
    ..Methodist Healthcare accredited by the ACCME to provide continuing medical education for physicians decided to co-sponsor this meeting and designated this educational activity for a maximum of 26 AMA PRA Category 1 Credits. ..
  68. Dose-dependent anti-inflammatory effects of vitamin D in a human gingivitis model
    Raul Garcia; Fiscal Year: 2009
    ..We hypothesize that oral cholecalciferol supplementation can reduce susceptibility to gingivitis over a wide range of serum 25-OHD concentrations in ..
  69. Vitamin D status in pregnant women
    Theresa Scholl; Fiscal Year: 2009
    ..Underscoring the importance of prevention during reproductive life is the fact that small infants born to the women may be at high risk of cardiovascular disease and type 2 diabetes in later life. ..
  70. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..abstract_text> ..
  71. Calcium, Vitamin D, and Markers of Adenomatous Polyps
    Roberd Bostick; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  72. CHEMISTRY AND PHYSIOLOGY OF BONE
    Mitsuo Yamauchi; Fiscal Year: 1991
    ..Phosphoprotein and collagen structure will be modeled by computer to ascertain structural relationships...