fish oils

Summary

Summary: Oils high in unsaturated fats extracted from the bodies of fish or fish parts, especially the livers. Those from the liver are usually high in vitamin A. The oils are used as dietary supplements, in soaps and detergents, as protective coatings, and as a base for other food products such as vegetable shortenings.

Top Publications

  1. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  2. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
  3. ncbi Blood levels of long-chain n-3 fatty acids and the risk of sudden death
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 346:1113-8. 2002
  4. pmc Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 332:752-60. 2006
  5. ncbi n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
  6. ncbi Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6703 HD Wageningen, Netherlands
    Am J Clin Nutr 90:415-24. 2009
  7. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
  8. ncbi Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2762-8. 2005
  9. ncbi Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Pennsylvania State University, Department of Nutritional Sciences, University Park, PA, USA
    Expert Opin Pharmacother 9:1237-48. 2008
  10. ncbi Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice
    Susanne Neschen
    Howard Hughes Medical Institute, Yale Medical School, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 55:924-8. 2006

Detail Information

Publications293 found, 100 shown here

  1. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  2. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..There have been a number of clinical trials assessing the benefits of dietary supplementation with fish oils in several inflammatory and autoimmune diseases in humans, including rheumatoid arthritis, Crohn's disease, ..
  3. ncbi Blood levels of long-chain n-3 fatty acids and the risk of sudden death
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 346:1113-8. 2002
    ..Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history of cardiovascular disease is unknown...
  4. pmc Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 332:752-60. 2006
    ..To review systematically the evidence for an effect of long chain and shorter chain omega 3 fatty acids on total mortality, cardiovascular events, and cancer...
  5. ncbi n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..A systematic review of the literature on the effects of n-3 FAs (consumed as fish or fish oils rich in eicosapentaenoic acid and docosahexaenoic acid or as alpha-linolenic acid) on cardiovascular disease ..
  6. ncbi Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6703 HD Wageningen, Netherlands
    Am J Clin Nutr 90:415-24. 2009
    ..Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown...
  7. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
    ..3 polyunsaturated fatty acids (n-3 PUFAs) are docosahexaenoic acid and eicosapentaenoic acid in the form of fish oils and alpha linolenic acid from flaxseed oil...
  8. ncbi Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2762-8. 2005
    ..Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients...
  9. ncbi Omega-3 fatty acid concentrates in the treatment of moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Pennsylvania State University, Department of Nutritional Sciences, University Park, PA, USA
    Expert Opin Pharmacother 9:1237-48. 2008
    ..Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people with very high triglycerides (> 500 mg/dl). Current guidelines recommend that triglycerides should be less < 150 mg/dl...
  10. ncbi Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice
    Susanne Neschen
    Howard Hughes Medical Institute, Yale Medical School, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 55:924-8. 2006
    ..These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPARgamma-dependent and PPARalpha-independent manner in epididymal fat...
  11. ncbi Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    Circulation 107:2646-52. 2003
  12. pmc Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers
    Stine M Ulven
    Faculty of Health, Nutrition, and Management, Akershus University College, Lillestrøm, Norway
    Lipids 46:37-46. 2011
    ..Krill oil and fish oil thus represent comparable dietary sources of n-3 PUFAs, even if the EPA + DHA dose in the krill oil was 62.8% of that in the fish oil...
  13. ncbi Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids
    Jing Cao
    University of Minnesota, Minneapolis, MN 55455, USA
    Clin Chem 52:2265-72. 2006
    ..To study the effects of fatty acid supplementation, we investigated the rate of incorporation and clearance of these fatty acids in erythrocyte membranes and plasma after intake of supplements...
  14. ncbi Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women
    Kevin C Maki
    Provident Clinical Research, Bloomington, IN 47403, USA Provident Clinical Research, Glen Ellyn, IL 60137, USA
    Nutr Res 29:609-15. 2009
    ..In conclusion, 4 weeks of krill oil supplementation increased plasma EPA and DHA and was well tolerated, with no indication of adverse effects on safety parameters...
  15. ncbi Omega-3 polyunsaturated fatty acids and cardiovascular diseases
    Carl J Lavie
    Department of Cardiovascular Diseases, Ochsner Medical Center, New Orleans, LA 70121 2483, USA
    J Am Coll Cardiol 54:585-94. 2009
    ....
  16. ncbi Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Arterioscler Thromb Vasc Biol 25:228-33. 2005
    ..We investigated the effects of high mercury content in hair on the risk of acute coronary events and cardiovascular and all-cause mortality in men from eastern Finland...
  17. ncbi An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids
    Mónica Venegas-Calerón
    Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Prog Lipid Res 49:108-19. 2010
    ..with one of the most promising being transgenic plants "reverse-engineered" to produce these so-called fish oils. Considerable progress has been made towards this goal and in this review we will outline the recent ..
  18. ncbi Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials
    Johanna M Geleijnse
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    J Hypertens 20:1493-9. 2002
    ..The antihypertensive effect of fish oil was estimated from randomized trials using metaregression analysis. Modification of the blood pressure (BP) effect by age, gender, blood pressure, and body mass index was examined...
  19. pmc Fish oil and postoperative atrial fibrillation: the Omega-3 Fatty Acids for Prevention of Post-operative Atrial Fibrillation (OPERA) randomized trial
    Dariush Mozaffarian
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    JAMA 308:2001-11. 2012
    ..A few small trials have evaluated whether long-chain n-3-polyunsaturated fatty acids (PUFAs) reduce postoperative AF, with mixed results...
  20. ncbi n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits
    Sarah K Gebauer
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 83:1526S-1535S. 2006
    ..Foods enriched with EPA and DHA or fish oil supplements are a suitable alternate to achieve recommended intakes and may be necessary to achieve intakes of 1 g/d...
  21. ncbi Lack of benefit of dietary advice to men with angina: results of a controlled trial
    M L Burr
    University of Wales College of Medicine, Cardiff, UK
    Eur J Clin Nutr 57:193-200. 2003
    ..To see whether mortality among men with angina can be reduced by dietary advice...
  22. ncbi Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial
    Janet A Dunstan
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    J Allergy Clin Immunol 112:1178-84. 2003
    ..There is growing interest in the potential role of anti-inflammatory n-3 polyunsaturated fatty acids (n-3 PUFAs) in the prevention of allergic disease...
  23. ncbi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
    ..EPA and DHA are found in oily fish and fish oils. EPA and DHA inhibit AA metabolism to inflammatory eicosanoids...
  24. ncbi Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain
    M Lagarde
    INSERM U352, Biochimie and Pharmacologie INSA Lyon, Villeurbanne, France
    J Mol Neurosci 16:201-4; discussion 215-21. 2001
    ..The results obtained allow us to raise the hypothesis that lysoPC may represent a preferred physiological carrier of DHA to the brain...
  25. pmc Feeding aquaculture in an era of finite resources
    Rosamond L Naylor
    Program on Food Security and the Environment, Stanford University, Encina East 404, Stanford, CA 94035, USA
    Proc Natl Acad Sci U S A 106:15103-10. 2009
    ..With appropriate economic and regulatory incentives, the transition toward alternative feedstuffs could accelerate, paving the way for a consensus that aquaculture is aiding the ocean, not depleting it...
  26. pmc Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet
    Zhi Hong Yang
    Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, Ltd, 32 3 Nanakuni 1 Chome Hachioji, Tokyo 192 0991, Japan
    Lipids Health Dis 10:189. 2011
    ..We therefore examined the effects of pollock oil, which contains a considerable amount of n-3 PUFAs as well as long-chain MUFAs, on plasma hyperlipidemia and hepatic steatosis in diet-induced obese mice...
  27. pmc Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat
    Elin Strand
    Institute of Medicine, University of Bergen, Haukeland University Hospital, Laboratory Building 8th floor, 5021 Bergen, Norway
    Lipids Health Dis 11:82. 2012
    ..Male Wistar rats were given one out of four different 25% (w/v) fat diets: control diet; TTA diet; FO diet; or diet containing both TTA and FO...
  28. ncbi Decreased tumor growth in Walker 256 tumor-bearing rats chronically supplemented with fish oil involves COX-2 and PGE2 reduction associated with apoptosis and increased peroxidation
    Rogeria C Mund
    Department of Physiology, University Federal of Parana, Biological Science Building, 81530 990, Curitiba, Brazil
    Prostaglandins Leukot Essent Fatty Acids 76:113-20. 2007
    ..Thus, FO may act simultaneously through multiple effects to reduce tumor growth. Whether these effects are connected through a single underlying mechanism remains to be seen...
  29. ncbi Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study
    Muriel J Caslake
    Department of Vascular Biochemistry, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
    Am J Clin Nutr 88:618-29. 2008
    ..The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits...
  30. pmc Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function
    Benjamin Drew Rockett
    Department of Biochemistry and Molecular Biology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA
    J Lipid Res 53:674-85. 2012
    ..Altogether, our studies with B cells support an emerging model that FO increases raft size and membrane order accompanied by functional changes; furthermore, the results highlight differences in EPA and DHA bioactivity...
  31. ncbi Dietary modification of inflammation with lipids
    Philip C Calder
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, UK
    Proc Nutr Soc 61:345-58. 2002
    ..PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in high proportions in oily fish and fish oils. The n-3 PUFA are structurally and functionally distinct from the n-6 PUFA...
  32. ncbi Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids
    Michael J James
    Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
    Am J Clin Nutr 77:1140-5. 2003
    ....
  33. ncbi Docosahexaenoic acid decreases plasma homocysteine via regulating enzyme activity and mRNA expression involved in methionine metabolism
    Tao Huang
    Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China
    Nutrition 26:112-9. 2010
    ..The objective of this study was to investigate the regulatory effect of fish oil rich in omega-3 polyunsaturated fatty acids (PUFAs) on critical enzyme activity and mRNA expression involved in homocysteine (Hcy) metabolism...
  34. ncbi Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus
    S McPhee
    Natural Products Research Group, School of Medical Sciences, Division of Laboratory Medicine, RMIT University, PO Box 71, Bundoora, Victoria 3083, Australia
    Comp Biochem Physiol B Biochem Mol Biol 146:346-56. 2007
    ..Incubation of Lyprinol in the absence of exogenous arachidonic acid (AA) showed the appearance of alternate prostaglandin metabolites, confirming Lyprinol PUFA as a competitive substrate inhibitor of AA metabolism...
  35. pmc Effect of fish oil supplementation on fasting vascular endothelial function in humans: a meta-analysis of randomized controlled trials
    Wei Xin
    First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, PR China
    PLoS ONE 7:e46028. 2012
    ..Effect of fish oil supplementation on flow-mediated dilation, an index of endothelial function in humans, remains controversial. We performed a meta-analysis to determine whether fish oil supplementation could improve endothelial function...
  36. ncbi An early fish oil-enriched diet reverses biochemical, liver and adipose tissue alterations in male offspring from maternal protein restriction in mice
    Isabele Bringhenti
    Laboratory of Morphometry, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, RJ, Brazil
    J Nutr Biochem 22:1009-14. 2011
    ..Early fish oil intake has beneficial effects on the programming responses that control body fat pad, glucose and lipid metabolism, and liver and adipose tissue structure in adult programmed offspring...
  37. ncbi Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice
    Yingchang Lu
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Genomics 43:1307-18. 2011
    ....
  38. ncbi Tailoring of Atlantic salmon (Salmo salar L.) flesh lipid composition and sensory quality by replacing fish oil with a vegetable oil blend
    Bente E Torstensen
    National Institute of Nutrition and Seafood Research, N 5817 Bergen, Norway
    J Agric Food Chem 53:10166-78. 2005
    ..At the same time, 75% of the dietary fish oil can be replaced without compromising flesh VLCn-3 PUFA content, thereby providing a beneficial nutritional profile for human consumption...
  39. pmc Arachidonate 5-lipoxygenase gene variants affect response to fish oil supplementation by healthy African Americans
    Patrice Armstrong
    USDA Western Human Nutrition Research Center, Davis, CA, USA
    J Nutr 142:1417-28. 2012
    ..No changes were seen in LDL particle or cholesterol concentrations, heart rate, or blood pressure. These findings indicate that the efficacy of FO supplements vary by ALOX5 genotype...
  40. ncbi Fish oil supplementation of lactating mothers affects cytokine production in 2 1/2-year-old children
    Lotte Lauritzen
    Center for Advanced Food Studies, Department of Human Nutrition, The Royal Veterinary and Agricultural University, 1958 Frederiksberg, Denmark
    Lipids 40:669-76. 2005
    ..Fish oil supplementation during lactation resulted in increased in vitro IFN-gamma production in the children 2 yr after the supplementation was given, which may reflect a faster maturation of the immune system...
  41. pmc Effects of fish oil supplementation on inflammatory markers in chronic heart failure: a meta-analysis of randomized controlled trials
    Wei Xin
    First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, Peoples Republic of China
    BMC Cardiovasc Disord 12:77. 2012
    ..In this meta-analysis, we aimed to evaluate the influence of fish oil supplementation on circulating levels of inflammatory markers in patients with chronic heart failure...
  42. pmc Effect of fish oil on arrhythmias and mortality: systematic review
    Hernando Leon
    Epidemiology Coordinating and Research EPICORE Centre, Edmonton, AB, Canada
    BMJ 337:a2931. 2008
    ..To synthesise the literature on the effects of fish oil-docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)-on mortality and arrhythmias and to explore dose response and formulation effects...
  43. ncbi Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation
    Kristof Vanschoonbeek
    Department of Human Biology, Nutrition and Toxicology Research and Cardiovascular Research Institutes of Maastricht, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1734-40. 2004
    ..We studied how fish oil intake influenced thrombin generation in plasma and which factors were involved herein...
  44. ncbi Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation
    Catrin Furuhjelm
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Allergy Immunol 22:505-14. 2011
    ..Furthermore, high proportions of DHA and EPA in maternal and infant plasma phospholipids were associated with less IgE-associated disease and a reduced severity of the allergic phenotype...
  45. pmc Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury
    Mark Puder
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Ann Surg 250:395-402. 2009
    ..The objective was to determine the safety and efficacy of a fish oil-based intravenous lipid emulsion (ILE) in the treatment of parenteral nutrition-associated liver disease (PNALD)...
  46. ncbi Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity
    Samira Samane
    Department of Pharmacology, Universite de Montreal, Montreal, Quebec, Canada
    Metabolism 58:909-19. 2009
    ..Our data also show for the first time that AO can improve some of the metabolic and insulin signaling abnormalities associated with HFHS feeding...
  47. ncbi Pilot study of dietary fatty acid supplementation in the treatment of adult periodontitis
    Elliot D Rosenstein
    Arthritis and Rheumatic Disease Center, St Barnabas Medical Center, 200 South Orange Avenue, Livingston, NJ 07039, USA
    Prostaglandins Leukot Essent Fatty Acids 68:213-8. 2003
    ..Additional studies will be necessary to more fully assess the potential of these agents to favorably affect periodontal inflammation...
  48. ncbi Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
    S Kalmijn
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Neurology 62:275-80. 2004
    ..To examine the associations of fatty acid and fish intake with cognitive function...
  49. ncbi Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation
    Yan Zhao
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506 0054, USA
    J Am Coll Nutr 23:71-8. 2004
    ..NF-kappaB is kept in an inactive form in the cytoplasm by IkappaB, the inhibitory subunit of NF-kappaB complex. Phosphorylation and subsequent degradation of IkappaB lead to NF-kappaB activation...
  50. ncbi Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review
    Lefkothea Stella Kremmyda
    Institute of Human Nutrition and Institute of Developmental Sciences, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Clin Rev Allergy Immunol 41:36-66. 2011
    ..Fish and fish oils are sources of long-chain n-3 PUFAs and these fatty acids act to oppose the actions of n-6 PUFAs...
  51. ncbi Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products
    Masayuki Wada
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:22254-66. 2007
    ....
  52. pmc Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases
    Yun Wang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    J Lipid Res 46:706-15. 2005
    ..In conclusion, changes in Elovl-5 expression may account for much of the nutritional and developmental control of fatty acid elongation activity in the rat liver...
  53. pmc A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels
    Clemens von Schacky
    Medizinische Klinik and Poliklinik Innenstadt, University of Munich, Munich, Germany
    Vasc Health Risk Manag 2:251-62. 2006
    ..two marine omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevalent in fish and fish oils, have been investigated as a strategy towards prophylaxis of atherosclerosis...
  54. ncbi Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis
    James K Roush
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    J Am Vet Med Assoc 236:67-73. 2010
    ..To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis...
  55. ncbi Chemical contaminants in aquafeeds and Atlantic salmon (Salmo salar) following the use of traditional- versus alternative feed ingredients
    Marc H G Berntssen
    National Institute of Nutrition and Seafood Research NIFES, P O Box 2029 Nordnes, 5817 Bergen, Norway
    Chemosphere 78:637-46. 2010
    ..The paper also compares the levels of contaminants in farmed Atlantic salmon expected in the future with those levels reported in the literature and currently on the market...
  56. pmc Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes
    Stefano Rizza
    Center for Atherosclerosis Policlinico Tor Vergata University Hospital, Internal Medicine Department, Rome, Italy
    Atherosclerosis 206:569-74. 2009
    ..Therefore, in the present study, we tested the hypothesis that dietary supplementation with fish oil rich in n-3 PUFA may improve ED in otherwise healthy OPDs...
  57. ncbi Comparative effects of DHA and EPA on cell function
    Renata Gorjao
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Pharmacol Ther 122:56-64. 2009
    ..Substantial improvement in the therapeutic usage of omega-3 fatty acid-rich FO will be possible with the discovery of the different mechanisms of actions of DHA and EPA...
  58. ncbi Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
    F Thies
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 73:539-48. 2001
    ..CONCLUSION: A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects...
  59. ncbi Effects of n-3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation
    Ingrid L Mostad
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, St Olavs Hospital, Trondheim, Norway
    Am J Clin Nutr 84:540-50. 2006
    ..Effects of fish oil supplements on metabolic variables are insufficiently clarified in type 2 diabetes...
  60. ncbi Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer
    Leandro C A Cerchietti
    Translational Research Unit, Angel H Roffo Cancer Institute, Universidad de Buenos Aires, Buenos Aires, Argentina
    Nutr Cancer 59:14-20. 2007
    ..This study shows that by modulating the eicosanoid metabolism using a combination of n-3 fatty acids and cyclooxygenase-2 inhibitor, some of the signs and symptoms associated with a SIMS could be ameliorated...
  61. ncbi Fish, long-chain omega-3 polyunsaturated fatty acids and prevention of cardiovascular disease--eat fish or take fish oil supplement?
    Ka He
    Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Prog Cardiovasc Dis 52:95-114. 2009
    ..Further studies are needed to investigate the potential adverse effects of contaminants in fish and the possible different effects from different types of fish and cooking methods...
  62. ncbi Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial
    Sjurdur F Olsen
    Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Am J Clin Nutr 88:167-75. 2008
    ..Evidence suggests that asthma is rooted in the intrauterine environment and that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnancy may have immunomodulatory effects on the child...
  63. pmc The role of adipose tissue in mediating the beneficial effects of dietary fish oil
    Michael J Puglisi
    Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232 0615, USA
    J Nutr Biochem 22:101-8. 2011
    ..Thus, there is compelling evidence that fish oil mediates its beneficial effects on MetS by improving AT storage and secretory functions and by reducing inflammation...
  64. ncbi Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid
    Gwendolyn Barcelo-Coblijn
    Department of Pharmacology, University of North Dakota, Grand Forks, ND, USA
    Am J Clin Nutr 88:801-9. 2008
    ....
  65. pmc Omega 3 fatty acids and cardiovascular disease--fishing for a natural treatment
    Jehangir N Din
    Cardiovascular Research, University of Edinburgh, Edinburgh EH16 4SB
    BMJ 328:30-5. 2004
  66. ncbi Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
    Inger Vedin
    Department of Medicine and the Division of Clinical Nutrition and Metabolism Research, Uppsala University Hospital, Uppsala, Sweden
    Am J Clin Nutr 87:1616-22. 2008
    ..Whereas most studies have explored the effects of predominantly EPA-based n-3 FAs preparations, few have addressed the effects of n-3 FAs preparations with DHA as the main FA...
  67. ncbi Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation
    Timothy Trebble
    The Institute of Human Nutrition, School of Medicine, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Br J Nutr 90:405-12. 2003
    ..Thus, increased dietary n-3 PUFA consumption resulted in defined but contrasting patterns of modulation of phospholipid fatty acid composition and PBMC function, which were further influenced by antioxidant intake...
  68. pmc Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice
    Lolita M Forrest
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, United States
    Atherosclerosis 220:118-21. 2012
    ..Echium oil contains stearidonic acid (SDA; 18:4, n-3), which is metabolized to EPA in humans and mice, resulting in decreased plasma triglycerides...
  69. ncbi Fish oil supplementation in F1 generation associated with naproxen, clenbuterol, and insulin administration reduce tumor growth and cachexia in Walker 256 tumor-bearing rats
    João A Pinto
    Department of Physiology, Biological Sciences Building, Federal University of Parana, 81530 990, Curitiba PR, Brazil
    J Nutr Biochem 15:358-65. 2004
    ..In conclusion, chronic fish oil supplementation decreased tumor growth and partially recovered cachexia. This beneficial effect of fish oil supplementation was potentiated by treatment with naproxen plus clenbuterol plus insulin...
  70. ncbi Comparative effects of perilla and fish oils on the activity and gene expression of fatty acid oxidation enzymes in rat liver
    T Ide
    Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2 1 2 Kannondai, Tsukuba Science City, Japan
    Biochim Biophys Acta 1485:23-35. 2000
    ..The mitochondrial fatty acid oxidation rate was 50% higher in rats fed perilla and fish oils than in the other groups...
  71. ncbi Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter
    Isabelle Romieu
    Instituto Nacional de Salud Publica, Cuernavaca, Mexico
    Am J Respir Crit Care Med 172:1534-40. 2005
    ..Environmental exposure to particulate matter of 2.5 microm or less (PM2.5) has been associated with changes in heart rate variability (HRV)...
  72. ncbi Altered fatty acid compositions in atlantic salmon (Salmo salar) fed diets containing linseed and rapeseed oils can be partially restored by a subsequent fish oil finishing diet
    J Gordon Bell
    Institute of Aquaculture, University of Stirling, Stirling, FK9 4LA, Scotland, UK
    J Nutr 133:2793-801. 2003
    ....
  73. pmc Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis
    Ayumi Sato
    Development Research, Pharmaceutical Research Center, Mochida Pharmaceutical, Shizuoka, Japan
    Diabetes 59:2495-504. 2010
    ..Given the pleiotropic effect of eicosapentaenoic acid (EPA), it is interesting to know whether EPA is capable of improving obesity. Here we examined the anti-obesity effect of EPA in mice with two distinct models of obesity...
  74. ncbi Long-term consumption of fish oil-enriched diet impairs serotonin hypophagia in rats
    Regina L H Watanabe
    Departamento de Fisiologia, Universidade Federal de Sao Paulo, Rua Botucatu, Sao Paulo, SP, Brazil
    Cell Mol Neurobiol 30:1025-33. 2010
    ..That fat pad weight increased in the absence of hyperphagia indicates that energy expenditure was affected by the serotonergic hypofunction...
  75. pmc Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content
    Susanne Neschen
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Am J Physiol Endocrinol Metab 282:E395-401. 2002
    ..In turn, an increased hepatic beta-oxidative capacity results in lower hepatic triglyceride/diacylglycerol and intramyocellular triglyceride/fatty acyl-CoA content...
  76. pmc Deep phenotyping of the unselected COPSAC2010 birth cohort study
    H Bisgaard
    Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte and Naestved, Denmark Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Clin Exp Allergy 43:1384-94. 2013
    ....
  77. ncbi The clinical effect of dietary supplementation with omega-3 fish oils and/or copper in systemic lupus erythematosus
    Emeir M Duffy
    Northern Ireland Center for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Ulster, Northern Ireland, UK
    J Rheumatol 31:1551-6. 2004
    To determine the effect of dietary supplementation with omega-3 fish oils with or without copper on disease activity in systemic lupus erythematosus (SLE)...
  78. ncbi Effects of fish oil supplementation on cardiac function in chronic heart failure: a meta-analysis of randomised controlled trials
    Wei Xin
    First Department of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    Heart 98:1620-5. 2012
    ..The effects of fish oil on cardiac function, ventricular remodelling and functional capacity in patients with chronic heart failure (CHF) remain controversial...
  79. ncbi Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma
    Timothy D Mickleborough
    Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E Seventh St, HPER 112, Bloomington, IN 47401, USA
    Chest 129:39-49. 2006
    ..Since EIB in asthma involves proinflammatory mediator release, it is feasible that fish oil supplementation may reduce the severity of EIB in asthmatic subjects...
  80. ncbi Ratio of n6 to n-3 fatty acids in the diet affects tumor growth and cachexia in Walker 256 tumor-bearing rats
    Nathalia Pizato
    Department of Physiology, Biological Sciences Building, Federal University of Parana, Curitiba, PR, Brazil
    Nutr Cancer 53:194-201. 2005
    ..In this experimental model, a dietary n-6 to n-3 FA ratio of 6:1 was able to increase food intake and body weight, restore the biochemical blood parameters of cachexia, and prevent the development of cancer cachexia...
  81. pmc Fish oil -- how does it reduce plasma triglycerides?
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research USD, SD, USA
    Biochim Biophys Acta 1821:843-51. 2012
    ..Thus reducing NEFA delivery to the liver would be a likely locus of action for fish oils (FO)...
  82. ncbi Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations
    E A Miles
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Clin Sci (Lond) 100:91-100. 2001
    ..043), with a median decrease of 20% (range 16-60%). These observations suggest that fish oil decreases endothelial activation in elderly subjects...
  83. ncbi Supplementation of fish oil and olive oil in patients with rheumatoid arthritis
    Alair Alfredo Berbert
    Department of Department of Pathology, Londrina State University, Parana, Brazil
    Nutrition 21:131-6. 2005
    ..This study evaluated whether supplementation with olive oil could improve clinical and laboratory parameters of disease activity in patients who had rheumatoid arthritis and were using fish oil supplements...
  84. ncbi Fish oil containing intravenous lipid emulsions in parenteral nutrition-associated cholestatic liver disease
    Berthold Koletzko
    Division of Metabolic and Nutritional Medicine, Dr von Hauner Children s Hospital, University of Munich Medical Center, Munich, Germany
    Curr Opin Clin Nutr Metab Care 13:321-6. 2010
    Lipid emulsions containing fish oils have been proposed to improve parenteral nutrition associated cholestasis (PNAC), a very serious complication of prolonged parenteral nutrition occurring particularly in infants and children with ..
  85. ncbi Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy
    Rachel A Murphy
    Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Cancer 117:1775-82. 2011
    ....
  86. ncbi Fish oil supplementation in the treatment of major depression: a randomised double-blind placebo-controlled trial
    Brin F S Grenyer
    Illawarra Institute for Mental Health and Smart Foods Centre, University of Wollongong NSW 2522, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 31:1393-6. 2007
    ..in essential omega-3 polyunsaturated fatty acids derived from fish are associated with depression and some fish oils may have therapeutic benefits...
  87. ncbi Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis
    Hillary L Woodworth
    Department of Food Science and Human Nutrition, Department of Pathobiology and Diagnostic Investigation, and College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
    Cancer Res 70:7960-9. 2010
    ..hepaticus infection, increasing colon cancer risk. These results support the need to establish a tolerable upper limit for DHA intake particularly in the context of chronic inflammatory conditions such as IBD...
  88. ncbi A new intravenous fat emulsion containing soybean oil, medium-chain triglycerides, olive oil, and fish oil: a single-center, double-blind randomized study on efficacy and safety in pediatric patients receiving home parenteral nutrition
    Olivier Goulet
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Hopital des Enfants Malades, University of Paris 5, René Descartes, France
    JPEN J Parenter Enteral Nutr 34:485-95. 2010
    ..The aim was to assess the efficacy and safety of this new ILE in pediatric patients receiving home parenteral nutrition (HPN) compared with soybean oil emulsion (SOE)...
  89. pmc A primary health-care intervention on pre- and postnatal risk factor behavior to prevent childhood allergy. The Prevention of Allergy among Children in Trondheim (PACT) study
    Ola Storrø
    Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMC Public Health 10:443. 2010
    ..The setting was in ordinary pre- and postnatal primary health care in Trondheim, Norway...
  90. ncbi Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective
    Matteo Nicola Dario Di Minno
    Department of Experimental and Clinical Medicine, Federico II University, Naples, Italy
    Thromb Haemost 104:664-80. 2010
    ..Major experimental data provide strength (biological plausibility) for these findings, and define directions for newer clinical trials with ω-3 fatty acids...
  91. ncbi Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition
    Erika Tomsits
    2nd Department of Paediatrics, Semmelweis University, Budapest, Hungary
    J Pediatr Gastroenterol Nutr 51:514-21. 2010
    ....
  92. ncbi Diet × genotype interactions in hepatic cholesterol and lipoprotein metabolism in Atlantic salmon (Salmo salar) in response to replacement of dietary fish oil with vegetable oil
    Sofia Morais
    Institute of Aquaculture, University of Stirling, Stirling FK9 4LA, Scotland, UK
    Br J Nutr 106:1457-69. 2011
    ..Finally, the presence of three different transcripts for LPL, with differential patterns of nutritional regulation, was demonstrated...
  93. ncbi Marine phospholipids--a promising new dietary approach to tumor-associated weight loss
    Lenka A Taylor
    Department of Clinical Research, Tumor Biology Center, Breisacher Strasse 117, 79106, Freiburg, Germany
    Support Care Cancer 18:159-70. 2010
    ..In this study, a new formulation of marine fatty acids was investigated, the marine phospholipids, with more than 50% of phospholipid-bound fatty acids being eicosapentaenoic and docosahexaenoic acid...
  94. pmc Effects of the total replacement of fish-based diet with plant-based diet on the hepatic transcriptome of two European sea bass (Dicentrarchus labrax) half-sibfamilies showing different growth rates with the plant-based diet
    Florian Geay
    IFREMER, UMR 1067, Departement Physiologie Fonctionnelle des Organismes Marins, Technopole Brest Iroise, BP 70, 29280 Plouzane, France
    BMC Genomics 12:522. 2011
    ..The main objective of the present study was to analyse the effects of a plant-based diet on the hepatic transcriptome of European sea bass (Dicentrarchus labrax)...
  95. ncbi Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
    Natalie Sinn
    School of Health Sciences, Sansom Institute for Health Research, Nutritional Physiology Research Centre, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia
    Br J Nutr 107:1682-93. 2012
    ..Increasing n-3 PUFA intakes may reduce depressive symptoms and the risk of progressing to dementia. This needs to be investigated in larger, depressed samples with MCI...
  96. ncbi Omega-3 fatty acids: cardiovascular benefits, sources and sustainability
    John H Lee
    Mid America Heart Institute and University of Missouri Kansas City, 64111, USA
    Nat Rev Cardiol 6:753-8. 2009
    ..Sustainable sources of omega-3 fatty acids will need to be identified if long-term cardiovascular risk reduction is to be achieved at the population level...
  97. ncbi n-3 polyunsaturated fatty acids do not alter immune and inflammation measures in endurance athletes
    David C Nieman
    Dept of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 19:536-46. 2009
    ....
  98. ncbi Effects of particle size on blood clearance and tissue uptake of lipid emulsions with different triglyceride compositions
    Kemin Qi
    Institute of Human Nutrition and Department of Pediatrics, Columbia University, New York, New York 10032, USA
    JPEN J Parenter Enteral Nutr 27:58-64. 2003
    ..Particle size of IV lipid emulsions affects the catabolism of long-chain triglyceride (LCT) emulsions, but little is known about its effect on the catabolism of medium-chain triglyceride (MCT)- and fish oil (FO)-containing emulsions...
  99. ncbi Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitus
    C Y Wong
    Cardiology Division, Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabet Med 27:54-60. 2010
    ..However, the effects of fish-oil supplement on vascular function and metabolic profile in patients with Type 2 diabetes mellitus (DM) are unclear...
  100. ncbi Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat
    P Flachs
    Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Diabetologia 48:2365-75. 2005
    ....
  101. ncbi Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children
    Hau D Le
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, MA, USA
    Am J Clin Nutr 94:749-58. 2011
    ..A fish-oil-based lipid emulsion (FOLE) as a component of PN can reverse PN-cholestasis and has been shown to improve lipid profiles...

Research Grants62

  1. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..unselected for disease risk) have never been conducted. The growing enthusiasm for supplemental vitamin D and fish oils underscores the urgent need for their timely testing, before their use becomes so prevalent as to render ..
  2. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..Therefore, this proposal will investigate how omega-3 fish oils affect inflammation, lipids and fat breakdown by comparing it to a non-fish oil omega-3 supplement (linolenic ..
  3. Prevention of high fat diet-induced vascular injury
    Ming Hui Zou; Fiscal Year: 2013
    ..by applicant): Overwhelming data from epidemiological studies and clinical trials reveal that consumption of fish oils (omega-3 polyunsaturated fatty acids) reduces cardiovascular deaths (CVD) and retards the progression of ..
  4. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..it may be the relative proportion of n-3 to n-6 PUFAs that best determines the chemopreventive effects of fish oils. This ratio is important because the n-6 PUFA, arachidonic acid (ARA), is converted via the cyclo-oxygenase ..
  5. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..plans for a randomized placebo-controlled clinical trial to test the benefits of daily omega-3 fatty acids (fish oils) supplements at reducing urine protein excretion and other biomarkers of kidney injury in adults with diabetes ..
  6. Effects of fish oil on inflammation and metabolic syndrome
    Philip A Kern; Fiscal Year: 2012
    ..In addition to their beneficial effects on serum lipids and heart disease, fish oils (&#969;-3 fatty acids) activate PPAR&#947;and demonstrate antiinflammatory properties...
  7. Effect of Nutritional Factors on Macrophage Accumulation in Adipose Tissue
    Alan Chait; Fiscal Year: 2012
    ..Conversely, fish oils appear to have the opposite effect and may protect against macrophage accumulation in visceral fat...
  8. Chemopreventive effect of fish oil derived EPA in lung cancer
    Peiying Yang; Fiscal Year: 2013
    ..We will determine the chemopreventive role of EPA and fish oils using a urethane- induced mouse lung cancer model with and without expression of COX-2, as well as the K-ras ..
  9. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..The influence of fish oils on prostanoid formation will be examined in collaborative studies...
  10. Walnuts vs. Walnut-Oil, Glucose Homeostasis, PCOS
    Sidika Kasim Karakas; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. OMEGA-3 FATTY ACIDS AND THE CEREBRAL CIRCULATION
    EARL ELLIS; Fiscal Year: 1993
    ..Some evidence suggests that fish oils also alter formation of the vasodilator prostaglandins (PGs) E2 and I2...
  12. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
    The low incidence of cardiovascular diseases among fish-eating populations has led to the hypothesis that fish oils containing omega-3 fatty acids (w3 FA) may be protective agents...
  13. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..favorably affect the balance between vasodilating and vasoconstricting prostanoids, and hypotensive effects of fish oils have been found in normal volunteers...
  14. DIET AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Carlos Camargo; Fiscal Year: 2002
    ..g., vitamin C, vitamin E, and carotenoids), magnesium, potassium, and n-3 polyunsaturated fatty acids (e.g., fish oils) decrease risk of COPD, whereas high intakes of specific fatty acids (e.g., linoleic acid) increase risk...
  15. Timing of Dietary Exposures and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2001
    ..We therefore propose that prepubertal exposure to some fatty acids (fish oils) and phytoestrogens reduce the risk of developing breast cancer...
  16. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..of the research to date has been on dietary (low sodium) and activity advice, and dietary supplements (garlic, fish oils)...
  17. ATHEROSCLEROSIS & W-3 FATTY ACIDS IN ALASKAN NATIVES
    William Newman; Fiscal Year: 1993
    ..but also will help in making a decision whether to recommend to the general public the inclusion of fish oils, which contain large amounts of these fatty acids in the diet, for prevention and/or reduction of ..
  18. EFFECTS OF CHD PREVENTION ON LIPOPROTEIN SUBCLASSES
    Paul Williams; Fiscal Year: 1993
    ..medications: colestipol, nicotinic acid, clofibrate, probucol, gemfibrozil, fenofibrate, lovastatin, guar gum or fish oils? 4...
  19. Omega-3 Fatty Acids and Heart Failure
    William Stanley; Fiscal Year: 2009
    ..a major clinical problem and frequently leads to chronic heart failure (HF) The omega-3 fatty acids found in fish oils (eicosapentanoic acid (EPA) and docohexanoic acid (DHA)) and in some plants (1-linolenic acid (ALA) in flax seed ..
  20. FATTY ACID ANTIARRYTHMIA TRIAL (FAAT)
    Alexander Leaf; Fiscal Year: 2000
    ..if the dietary n-3 class of polyunsaturated fatty acids (PUFAs), provided in our diet largely from marine fish oils, will prevent fatal ventricular tachycardia (VT) and fibrillation (VF) in humans...
  21. CARDIOVASCULAR SURGICAL STUDIES OF OMEGA-3 FATTY ACIDS
    D Miller; Fiscal Year: 1991
    ..The objectives are to define the therapeutic potential of OMEGA-3 fish oils in cardiovascular disease and support these clinical implications with a more solid understanding of the ..
  22. MARINE LIPIDS AND ENDOTHELIAL CELLS IN ATHEROSCLEROSIS
    Paul Fox; Fiscal Year: 1992
    ..an early and critical event in the formation of occlusive atherosclerotic lesions; (2) that ingestion of fish or fish oils containing n-3 polyunsaturated fatty acids (PUFAs) inhibits intimal thickening in experimental animals, and may ..
  23. DIETARY ETHER-LINKED LIPIDS AND N-3 FATTY ACIDS
    FRED SNYDER; Fiscal Year: 1993
    ..Abstract): The O-alkyl ether linkage in glycerolipids was originally discovered as a significant component of fish oils. As with the n-3 fatty acids, fish from the ocean are thought to be highly enriched in ether lipids...
  24. Nostalgia in the WNT signaling pathway; fatty acids, epigenetics and leukemia
    Vincent Sollars; Fiscal Year: 2009
    ..This proposal will draw connections between exposure to specific types of fatty acids, such as those present in fish oils, to protection from cancer. A mechanism has been proposed for the basis of this interaction and will be tested.
  25. PREVENTION OF MITOCHONDRIAL AGING BY OMEGA-3 FATTY ACIDS
    William Stillwell; Fiscal Year: 1991
    DESCRIPTION (Investigator's Abstract): Fish oils, a rich source of long chain polyunsaturated omega-3 fatty acids, have been linked through epidemiologic studies to the prevention of a number of important human afflictions including ..
  26. DO FISH OILS PREVENT RESTENOSIS POST-CORONARY ANGIOPLAST
    Alexander Leaf; Fiscal Year: 1992
    ..There is much confusion in the minds of both the public and physicians regarding possible beneficial health effects of fish oil. This study is undertaken to establish factual information on which to judge this issue...
  27. Relevance of fish oil derived PGE3 to lung cancer
    Robert Newman; Fiscal Year: 2004
    We hypothesize that the fish oils, EPA and DHA, can serve as effective chemopreventive agents against lung cancer and that this protective effect is mediated by selective alteration of arachidonate metabolism through cyclooxygenase ..
  28. DOCOSAHEXAENOIC ACID FROM MICROALGAE
    DAVID KYLE; Fiscal Year: 1992
    ..Attempts at supplementing infant formulas with fish oils have led to rejection due to the strong fishey odor and taste and high levels of eicosapentaenoic acid (EPA)...
  29. HOW DIETARY N-3 FATTY ACIDS PREVENT FATAL ARRHYTHMIAS
    Alexander Leaf; Fiscal Year: 2001
    Specific Aims: We have shown that the n-3 polyunsaturated fatty acids (PUFAs) in fish oils, which prevent sudden cardiac death, like local anesthetics, inhibit the fast, voltage dependent Na+ currents (i.e...
  30. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  31. CELLULAR SIGNALING IN RENAL PATHOPHYSIOLOGY
    JOSEPH GRANDE; Fiscal Year: 2008
    ..abstract_text> ..
  32. Signaling Pathways in Pathogenesis of Renal Fibrosis
    JOSEPH GRANDE; Fiscal Year: 2004
    ..If successful, these interventions may retard progression of tissue injury to end-stage disease. ..
  33. OMEGA 3 LIPIDS AND CALORIES EFFECT ON SLE AND AGING
    Gabriel Fernandes; Fiscal Year: 2003
    ....
  34. Effect of Calorie Restriction on Infection During Aging
    Gabriel Fernandes; Fiscal Year: 2004
    ..This new information may become very useful to prevent any sudden onset of infection during CR studies and/or studies of weight reduction either by diet or by drugs in humans. ..
  35. Prolongation of lifespan by n-3 fatty acids and calorie restriction
    GABRIEL J FERNANDES; Fiscal Year: 2010
    ..n-3 (fish oil) fatty acids containing diets fed to mice ad-libitum and 40% or 20% calorie restriction to measure optimal lifespan, anti-inflammatory cytokines and bone mass, in long-lived C57BL/6 and fat-1 tg mice. ..
  36. EFFECTS OF n-3 FATTY ACIDS AND EXERCISE ON OSTEOPOROSIS
    Gabriel Fernandes; Fiscal Year: 2008
    ..In summary, the proposed studies will investigate the dietary and molecular mechanisms of bone loss during aging in OVX mice and its attenuation by low-cost n-3 lipid supplements with moderate exercise as alternatives to HRT. ..
  37. Benefits of conjugated linoleic acid on aging
    Gabriel Fernandes; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  38. Prostate Microenvironmental & Prostate Cancer Progression
    June Chan; Fiscal Year: 2009
    ....
  39. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  40. Incarceration and HIV-Infected Inmates
    David A Wohl; Fiscal Year: 2010
    ..Aim 2. Determine the inmate, nurse-counselor and facility characteristics associated with agreeing to HIV VCT. Aim 3. Explore the risks associated with receiving an HIV diagnosis in prison. ..
  41. Genetic Determinants of Sudden Cardiac Death
    Christine Albert; Fiscal Year: 2006
    ..The findings generated will have substantial implications for our understanding of the SCD syndrome and risk stratification in the general population. ..
  42. NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONS
    Bruce Levy; Fiscal Year: 2002
    ..End of Abstract) ..
  43. DIETARY LIPIDS AND EXPERIMENTAL IGA NEPHROPATHY
    James Pestka; Fiscal Year: 2009
    ..abstract_text> ..
  44. Dietary Patterns, Obesity and Associated Metabolic Outcomes in Adolescent Girls
    LYNN MOORE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Huiyong Yin; Fiscal Year: 2008
    ..Studies will examine mechanisms related to the formation, metabolism and biological actions of glyceryMsoPs in vivo. ..
  46. ENDOTOXIN AND SUSCEPTIBILITY TO TRICHOTHECENE MYCOTOXINS
    James Pestka; Fiscal Year: 2002
    ..Over the long term, this research will provide insight into adverse immunologic consequences that may occur in LPS-exposed individuals who are exposed to environmental toxicants." ..
  47. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..
  48. Creatine: Is It a Body Builder for Cancer Patients?
    Aminah Jatoi; Fiscal Year: 2004
    ..obtain longitudinal toxicity and quality of life data on this same cohort of 50 patients and will make direct comparisons between treatment arms on toxicity incidence and severity and on maximal quality of life scores ..
  49. Gene-diet interactions and dietary cholesterol response
    Jan Breslow; Fiscal Year: 2005
    ..of additional novel dietary cholesterol regulated genes and other genes determining differences in cholesterol metabolism and diet response between the sexes will be performed utilizing oligonucleotide microarrays, ..
  50. Oral Pathogens: Polymicrobial Virulence Interactions
    KESAVALU LAKSHMYYA; Fiscal Year: 2006
    ..Consequently, the host response to these chronic infections must be considered as critical to general health. ..
  51. CHOLESTEROL REDUCTION EFFECTS ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 2001
    ..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
  52. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  53. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  54. Vitamin A Regulates Th1/Th2 Development via RXR Pathway
    Charles Stephensen; Fiscal Year: 2007
    ..In addition, receptor-selective retinoids are currently used in cancer therapy and are being evaluated for diabetes. This work will help evaluate possible side effects of these therapies. ..
  55. Active Living and Healthy Diet at the Workplace
    STEPHENIE LEMON; Fiscal Year: 2007
    ..Intervention implementation and evaluation will occur during Phase II. A dissemination plan will then be implemented in collaboration with NHLBI and other funded projects. ..
  56. Gene-Environment Interactions in Obesity and Diabetes
    Tracy Nelson; Fiscal Year: 2007
    ..Environment: Dr. Nelson will have an outstanding environment in which to carry out the proposed study, as well as, the necessary resources and support to successfully complete her training. ..
  57. Dietary Macronutrients and Weight Loss
    Frank Sacks; Fiscal Year: 2008
    ..The results will be straightforwardly applicable to public health and clinical guidelines for obesity, and will increase our understanding of the biology of obesity and weight loss. ..
  58. KINETICS OF HUMAN POSTPRANDIAL LIPOPROTEIN METABOLISM
    Frank Sacks; Fiscal Year: 2001
    ..These studies will increase our understanding of the metabolic pathways that are activated or suppressed postprandially, and could lead to treatments for reducing the development of atherosclerosis. ..
  59. Variation in the ALOX5 gene and response to omega-3 fatty acid supplements
    Charles Stephensen; Fiscal Year: 2007
    ..Indicators of cardiovascular risk will also be assessed before and after intervention, including blood lipid profile, blood pressure, heart rate, and plasma CRP, glucose and insulin concentrations. [unreadable] [unreadable] [unreadable]..
  60. MODIFIABLE RISK FACTORS FOR SUDDEN DEATH IN MEN/WOMEN
    Christine Albert; Fiscal Year: 2002
    ..At the end of the proposed research program, Dr. Albert will have attained advanced epidemiologic skills which can then be applied to independent research in her chosen subspecialty of electrophysiology. ..