vitellogenins

Summary

Summary: Phospholipoglycoproteins produced in the fat body of egg-laying animals such as non-mammalian VERTEBRATES; ARTHROPODS; and others. Vitellogenins are secreted into the HEMOLYMPH, and taken into the OOCYTES by receptor-mediated ENDOCYTOSIS to form the major yolk proteins, VITELLINS. Vitellogenin production is under the regulation of steroid hormones, such as ESTRADIOL and JUVENILE HORMONES in insects.

Top Publications

  1. ncbi Investigating compensation and recovery of fathead minnow (Pimephales promelas) exposed to 17alpha-ethynylestradiol with metabolite profiling
    D R Ekman
    Ecosystems Research Division, U S EPA, 960 College Station Road, Athens, Georgia 30605, USA
    Environ Sci Technol 42:4188-94. 2008
  2. pmc Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity
    Miguel Corona
    Department of Entomology, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:7128-33. 2007
  3. ncbi Oogenesis in teleosts: how eggs are formed
    Esther Lubzens
    Department of Marine Biology, Israel Oceanographic and Limnological Research, 81080 Haifa, Israel
    Gen Comp Endocrinol 165:367-89. 2010
  4. ncbi Molecular characteristics of insect vitellogenins and vitellogenin receptors
    T W Sappington
    Department of Entomology, Michigan State University, East Lansing 48824, USA
    Insect Biochem Mol Biol 28:277-300. 1998
  5. ncbi Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents
    S Jobling
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
    Biol Reprod 66:272-81. 2002
  6. pmc Collapse of a fish population after exposure to a synthetic estrogen
    Karen A Kidd
    Fisheries and Oceans Canada, Freshwater Institute, 501 University Crescent, Winnipeg, Manitoba, Canada R3T 2N6
    Proc Natl Acad Sci U S A 104:8897-901. 2007
  7. pmc The gene vitellogenin has multiple coordinating effects on social organization
    C Mindy Nelson
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS Biol 5:e62. 2007
  8. ncbi Molecular characteristics of insect vitellogenins
    Muhammad Tufail
    Graduate School of Science and Technology, Kobe University, Nada, Kobe 657 8501, Japan
    J Insect Physiol 54:1447-58. 2008
  9. ncbi Relative potencies and combination effects of steroidal estrogens in fish
    Karen L Thorpe
    School of Biological Sciences, The Hatherly Laboratory, Exeter University, The Prince of Wales Road, Exeter, Devon, EX4 4PS, UK
    Environ Sci Technol 37:1142-9. 2003
  10. ncbi Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect
    Karina R Guidugli
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    FEBS Lett 579:4961-5. 2005

Research Grants

  1. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2013
  2. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    ARDEN LEA; Fiscal Year: 1991
  3. GENDER EFFECTS ON SUSCEPTIBILITY TO LIVER NEOPLASIA
    David Hinton; Fiscal Year: 1999
  4. REGULATION OF APOLIPOPROTEIN METABOLISM--A TURTLE MODEL
    IAN CALLARD; Fiscal Year: 1993
  5. ESTROGEN AND VIGILIN CONTROL OF MRNA STABILITY
    David Shapiro; Fiscal Year: 2004
  6. ALLOSTERIC REGULATION OF THE ESTROGEN RECEPTOR BY DNA
    FERN MURDOCH; Fiscal Year: 1999
  7. REGULATION OF ESTROGEN-RESPONSIVE GENES
    Marilyn Evans; Fiscal Year: 2000
  8. HORMONE REGULATION--VITELLOGENIN & LIPOPROTEIN SYNTHESIS
    David Williams; Fiscal Year: 1990
  9. REGULATION OF VITELLOGENIC GENES IN THE MOSQUITO
    Alexander Raikhel; Fiscal Year: 2000
  10. ULTRASTRUCTURAL STUDIES OF DROSOPHILA DEVELOPMENT
    ANTHONY MAHOWALD; Fiscal Year: 1991

Detail Information

Publications361 found, 100 shown here

  1. ncbi Investigating compensation and recovery of fathead minnow (Pimephales promelas) exposed to 17alpha-ethynylestradiol with metabolite profiling
    D R Ekman
    Ecosystems Research Division, U S EPA, 960 College Station Road, Athens, Georgia 30605, USA
    Environ Sci Technol 42:4188-94. 2008
    ..This revealed an apparent ability of the fish to compensate for the presence of EE2 later in the exposure, and to partially recover from its effects after the chemical was removed...
  2. pmc Vitellogenin, juvenile hormone, insulin signaling, and queen honey bee longevity
    Miguel Corona
    Department of Entomology, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:7128-33. 2007
    ..These results suggest that conserved and species-specific mechanisms interact to regulate queen bee longevity without sacrificing fecundity...
  3. ncbi Oogenesis in teleosts: how eggs are formed
    Esther Lubzens
    Department of Marine Biology, Israel Oceanographic and Limnological Research, 81080 Haifa, Israel
    Gen Comp Endocrinol 165:367-89. 2010
    ..The role of blood-borne and local ovarian factors in the regulation of the key steps of development reveal new aspects associated with egg formation...
  4. ncbi Molecular characteristics of insect vitellogenins and vitellogenin receptors
    T W Sappington
    Department of Entomology, Michigan State University, East Lansing 48824, USA
    Insect Biochem Mol Biol 28:277-300. 1998
    The recent cloning and sequencing of several insect vitellogenins (Vg), the major yolk protein precursor of most oviparous animals, and the mosquito Vg receptor (VgR) has brought the study of insect vitellogenesis to a new plane...
  5. ncbi Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents
    S Jobling
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom
    Biol Reprod 66:272-81. 2002
    ....
  6. pmc Collapse of a fish population after exposure to a synthetic estrogen
    Karen A Kidd
    Fisheries and Oceans Canada, Freshwater Institute, 501 University Crescent, Winnipeg, Manitoba, Canada R3T 2N6
    Proc Natl Acad Sci U S A 104:8897-901. 2007
    ..Our observations demonstrate that the concentrations of estrogens and their mimics observed in freshwaters can impact the sustainability of wild fish populations...
  7. pmc The gene vitellogenin has multiple coordinating effects on social organization
    C Mindy Nelson
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS Biol 5:e62. 2007
    ..Further, they demonstrate for the first time how coordinated control of multiple social life-history traits can originate via the pleiotropic effects of a single gene that affects multiple physiological processes...
  8. ncbi Molecular characteristics of insect vitellogenins
    Muhammad Tufail
    Graduate School of Science and Technology, Kobe University, Nada, Kobe 657 8501, Japan
    J Insect Physiol 54:1447-58. 2008
    b>Vitellogenins (Vgs) are precursors of the major egg storage protein, vitellin (Vn), in many oviparous animals...
  9. ncbi Relative potencies and combination effects of steroidal estrogens in fish
    Karen L Thorpe
    School of Biological Sciences, The Hatherly Laboratory, Exeter University, The Prince of Wales Road, Exeter, Devon, EX4 4PS, UK
    Environ Sci Technol 37:1142-9. 2003
    ....
  10. ncbi Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect
    Karina R Guidugli
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brazil
    FEBS Lett 579:4961-5. 2005
    ..This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior...
  11. ncbi Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17beta-estradiol
    Yan Tong
    Department of Biological Sciences, National University of Singapore, Block S2 No 05 17, 14 Science Drive 4, 10 King Ridge Crescent, Singapore 119260, Singapore
    Gene 328:25-36. 2004
    ..The implication of these observations may be that the medaka system is better in monitoring acute treatment while the zebrafish system is better in monitoring chronic exposure...
  12. ncbi FoxO inhibits juvenile hormone biosynthesis and vitellogenin production in the German cockroach
    Songül Süren-Castillo
    Institut de Biologia Evolutiva CSIC UPF, Passeig Marítim de la Barceloneta 37 49, 08003 Barcelona, Spain
    Insect Biochem Mol Biol 42:491-8. 2012
    ..Our results indicate that BgFoxO plays an inhibitory role on juvenile hormone biosynthesis and vitellogenin production in a situation of nutrient shortage...
  13. ncbi The regulatory anatomy of honeybee lifespan
    Gro Vang Amdam
    Department of Animal Science, Agricultural University of Norway, 1432 Aas, Norway
    J Theor Biol 216:209-28. 2002
    ....
  14. ncbi Adaptive evolution of a key gene affecting queen and worker traits in the honey bee, Apis mellifera
    Clement F Kent
    Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada
    Mol Ecol 20:5226-35. 2011
    ..Our case study provides unequivocal evidence of historical and ongoing bouts of adaptive evolution acting on a key socially pleiotropic gene in the honey bee...
  15. ncbi Vitellogenin is a novel player in defense reactions
    Xiaodong Shi
    Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao 266003, China
    Fish Shellfish Immunol 20:769-72. 2006
    ..These suggest that in addition to being involved in yolk protein formation, Vg is also involved in defense reactions, a novel function assigned to Vg...
  16. ncbi Characterisation of two vitellogenins in the salmon louse Lepeophtheirus salmonis: molecular, functional and evolutional analysis
    Sussie Dalvin
    Institute of Marine Research, 5817 Bergen, Norway
    Dis Aquat Organ 94:211-24. 2011
    ..Here, we report on the characterisation of 2 vitellogenins (LsVit1 and LsVit2), which are the precursors of salmon-louse egg-yolk glycoprotein...
  17. ncbi Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio
    Hai Wang
    Department of Biological Sciences, National University of Singapore, Singapore 119260, Singapore
    Gene 356:91-100. 2005
    b>Vitellogenins (Vtgs) are yolk precursor proteins in oviparous species and are cleaved into three portions-lipovitellin I (LVI), phosvitin (PV), and lipovitellin II (LVII)-in oocytes in vertebrates...
  18. ncbi Induction of vitellogenin gene transcription in vitro by juvenile hormone in Blattella germanica
    D Comas
    Department of Physiology and Molecular Biodiversity, Institut de Biologia Molecular de Barcelona (CID, CSIC, J. Girona 18, 08034 Barcelona, Spain
    Mol Cell Endocrinol 183:93-100. 2001
    ..The presence in the medium of brain extract (0.5 equivalents), corpora cardiaca (one pair) or hypertrehalosemic hormone (10(-7) or 10(-8) M), partially inhibited the response to JH III...
  19. ncbi RNAi-mediated silencing of vitellogenin gene function turns honeybee (Apis mellifera) workers into extremely precocious foragers
    David Santos Marco Antonio
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Naturwissenschaften 95:953-61. 2008
    ....
  20. pmc Disruption of vitellogenin gene function in adult honeybees by intra-abdominal injection of double-stranded RNA
    Gro V Amdam
    Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway, N 1432 Aas, Norway
    BMC Biotechnol 3:1. 2003
    ..Here we assess two methods for probing gene function by RNA interference (RNAi) in adult honeybees...
  21. ncbi Reproductive effects of long-term exposure to Bisphenol A in the fathead minnow (Pimephales promelas)
    P Sohoni
    Department of Biological Sciences, Brunel University, Uxbridge, UB8 3PH
    Environ Sci Technol 35:2917-25. 2001
    ..The results demonstrate that BPA acts as a weak estrogen to fish when administered via the water, with effects on breeding at and above 640 micrograms/L...
  22. ncbi Microsomal triglyceride transfer protein promotes the secretion of Xenopus laevis vitellogenin A1
    Jeremy A Sellers
    Department of Pathology, Wake Forest University School of Medicine Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 280:13902-5. 2005
    b>Vitellogenins (Vtg) are ancient lipid transport and storage proteins and members of the large lipid transfer protein (LLTP) gene family, which includes insect apolipophorin II/I, apolipoprotein B (apoB), and the microsomal triglyceride ..
  23. ncbi Identification of a juvenile hormone esterase-like gene in the honey bee, Apis mellifera L.--expression analysis and functional assays
    Aline Mackert
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Comp Biochem Physiol B Biochem Mol Biol 150:33-44. 2008
    ..The temporal profile of Amjhe-like expression in larval and adult workers, the pattern of hormonal regulation and the knockdown phenotype are consistent with the function of this gene as an authentic JHE...
  24. ncbi Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees
    Gro V Amdam
    Department of Animal Science, Centre for Integrative Genetics, Agricultural University of Norway, P O Box 5025, 1432 Aas, Norway
    Exp Gerontol 39:767-73. 2004
    ..Our results therefore suggest that in terms of maintenance of the cellular immune system, senescence of the honeybee worker is under social control...
  25. pmc Social exploitation of vitellogenin
    Gro V Amdam
    Centre for Integrative Genetics and Department of Animal Science, Agricultural University of Norway, Box 5025, N 1432 Aas, Norway
    Proc Natl Acad Sci U S A 100:1799-802. 2003
    ..This finding suggests that the evolution of a brood-rearing worker class and a specialized forager class in an advanced eusocial insect society has been directed by an alternative utilization of yolk protein...
  26. ncbi Role of the male BmDSX protein in the sexual differentiation of Bombyx mori
    Masataka G Suzuki
    Laboratory of Molecular Entomology and Baculovirology, The Institute of Physical and Chemical Research RIKEN 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Evol Dev 7:58-68. 2005
    ..Taken together with our previous data on the function of BmDSXF, we can conclude that Bmdsx is a double-switch gene at the final step in the sex-determination cascade of B. mori...
  27. pmc Reproductive ground plan may mediate colony-level selection effects on individual foraging behavior in honey bees
    Gro V Amdam
    Department of Entomology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11350-5. 2004
    ..We suggest that exploitation of this ground plan plays a fundamental role in the evolution of social insect societies...
  28. ncbi Receptor-ligand interaction between vitellogenin receptor (VtgR) and vitellogenin (Vtg), implications on low density lipoprotein receptor and apolipoprotein B/E. The first three ligand-binding repeats of VtgR interact with the amino-terminal region of Vtg
    Ankang Li
    Department of Biological Sciences, National University of Singapore, Singapore 119260
    J Biol Chem 278:2799-806. 2003
    ....
  29. ncbi Transcriptional regulation of the mosquito vitellogenin gene via a blood meal-triggered cascade
    V A Kokoza
    Department of Entomology and Program in Genetics, Michigan State University, East Lansing, MI 48824, USA
    Gene 274:47-65. 2001
    ..The present work elucidates the molecular basis of blood meal-dependent expression of this mosquito gene, laying the foundation for mosquito-specific expression cassettes with predictable stage and tissue specificity...
  30. ncbi Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)
    R Lange
    Experimental Toxikologie, Schering AG Research Laboratories, D 13342 Berlin, Germany
    Environ Toxicol Chem 20:1216-27. 2001
    ..A lack of sexual differentiation occurred in males at concentrations > or = 4.0 ng/L. Taking into account these data, the overall no-observed-adverse-effect concentration was considered to be 1.0 ng/L...
  31. ncbi Hemagglutinating and antibacterial activities of vitellogenin
    Shicui Zhang
    Department of Marine Biology, 5 Yushan Road, Ocean University of China, Qingdao 266003, PR China
    Fish Shellfish Immunol 19:93-5. 2005
  32. ncbi Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, Japan
    S Hashimoto
    Department of Ocean Sciences, Tokyo University of Fisheries, 4 5 7 Konan, Minato ku, Tokyo 108 8477, Japan
    Mar Environ Res 49:37-53. 2000
    ..This study suggests that the abnormally high levels of VTG and the presence of oocytes in the testis of male flounder collected from Tokyo Bay could be the effect of environmental estrogens...
  33. ncbi The vitellogenin of the bumblebee, Bombus hypocrita: studies on structural analysis of the cDNA and expression of the mRNA
    Jilian Li
    Key Laboratory of Pollinating Insect Biology of the Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Science, Xiangshan, 100093, Beijing, China
    J Comp Physiol B 180:161-70. 2010
    ..Afterward, it decreased progressively. Vg mRNA was also observed in drones, with a higher level of expression shown in only freshly molted adult drones...
  34. ncbi Differential effects of insemination volume and substance on reproductive changes in honey bee queens (Apis mellifera L.)
    E L Niño
    Department of Entomology, North Carolina State University, Raleigh, NC, USA
    Insect Mol Biol 22:233-44. 2013
    ..We also discuss the effects on two genes (vitellogenin and transferrin) involved in reproduction and defence responses...
  35. pmc Insulin-like peptide genes in honey bee fat body respond differently to manipulation of social behavioral physiology
    Kari Anne Nilsen
    University of Life Sciences, Department of Chemistry, Biotechnology and Food Science, N 1432 Aas, Norway
    J Exp Biol 214:1488-97. 2011
    ..Insect ilp functions may be better understood by broadening research to account for expression in fat body and not only brain...
  36. ncbi Characterization of a pattern recognition molecule vitellogenin from carp (Cyprinus carpio)
    Qing Hui Liu
    Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, No 106, Nanjing Road, Qingdao 266071, China
    Immunobiology 214:257-67. 2009
    ..aureus. Vg also bind with macrophage function as opsonins to promote phagocytosis. The results suggest that Vg serves as a pattern recognition molecule and opsonins in antibacterial defense and as an effector in fish innate immunity...
  37. pmc Vitellogenin functions as a multivalent pattern recognition receptor with an opsonic activity
    Zhaojie Li
    Department of Marine Biology, Ocean University of China, Qingdao, People s Republic of China
    PLoS ONE 3:e1940. 2008
    ..Vitellogenin (Vg), a major reproductive protein, has been associated with infection-resistant response in fish. However, the underlying mechanisms by which Vg is involved in anti-infectious response are not understood...
  38. ncbi Altered physiology in worker honey bees (Hymenoptera: Apidae) infested with the mite Varroa destructor (Acari: Varroidae): a factor in colony loss during overwintering?
    Gro V Amdam
    Department of Entomology, University of California, Davis, CA 95616, USA
    J Econ Entomol 97:741-7. 2004
    ..Beekeepers in temperate climates should therefore combine late autumn management strategies with treatment protocols that keep the mite population at low levels before and during the period when the winter bees emerge...
  39. ncbi The first vitellogenin receptor from a Lepidopteran insect: molecular characterization, expression patterns and RNA interference analysis
    Y H Shu
    State Key Laboratory of Biological Control and Institute of Entomology, Sun Yat Sen University, Guangzhou, China
    Insect Mol Biol 20:61-73. 2011
    ..These results mean that VgR is critical for binding Vg and transporting it into the oocytes of the insect ovary, thus playing an important role in insect reproduction...
  40. ncbi Deduced primary structure of vitellogenin in the giant freshwater prawn, Macrobrachium rosenbergii, and yolk processing during ovarian maturation
    Atsuro Okuno
    Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    J Exp Zool 292:417-29. 2002
    ..The three processed subunits A, B, and C/D are sequestered by the ovary to give rise to three yolk proteins, Macr-VnA, VnB, and VnC/D...
  41. ncbi The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins
    C J Mann
    MRC Molecular Medicine Group, Imperial College School of Medicine, London W12 ONN, UK
    J Mol Biol 285:391-408. 1999
    ..The structural and functional evolution of the VTGs provides a unifying scheme for the invertebrate origins of the major vertebrate lipid transport system...
  42. ncbi Comparative study on the in vitro/in vivo estrogenic potencies of 17beta-estradiol, estrone, 17alpha-ethynylestradiol and nonylphenol
    K Van den Belt
    VITO Flemish Institute for Technological Research, Expertisecenter Environmental Toxicology, Boeretang 200 B 2400 MOL, Belgium
    Aquat Toxicol 66:183-95. 2004
    ....
  43. pmc Juvenile hormone regulation of vitellogenin synthesis in the red flour beetle, Tribolium castaneum
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Insect Biochem Mol Biol 40:405-14. 2010
    ..These data suggest that JH is required for Vg synthesis in the fat body and 20E influences Vg synthesis through its action on oocyte maturation...
  44. pmc Juvenile hormone regulates vitellogenin gene expression through insulin-like peptide signaling pathway in the red flour beetle, Tribolium castaneum
    Zhentao Sheng
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, Kentucky 40546, USA
    J Biol Chem 286:41924-36. 2011
    ..FOXO protein expressed in baculovirus system binds to FOXO response element present in the Vg gene promoter. These data suggest that JH functions through insulin-like peptide signaling pathway to regulate Vg gene expression...
  45. ncbi Purification and partial characterization of vitellogenin from shorthead redhorse (Moxostoma macrolepidotum) and copper redhorse (Moxostoma hubbsi) and detection in plasma and mucus with a heterologous antibody
    D Maltais
    Pêches et Océans Canada, Institut Maurice Lamontagne, 850 route de la Mer, P O Box 1000, Mont Joli, QC G5H 3Z4, Canada
    Fish Physiol Biochem 35:241-54. 2009
    ..Using this antibody, VTG was detected in plasma and surface mucus of E2B-treated redhorse. This is the most extensive report on purification and characterization of vitellogenin from catostomidid species...
  46. ncbi Temporal and spatial variability in the estrogenicity of a municipal wastewater effluent
    Jon M Hemming
    Ecological Services Division, US Fish and Wildlife Service, Panama City Field Office, 1601 Balbao Avenue, Panama City, FL 32405, USA
    Ecotoxicol Environ Saf 57:303-10. 2004
    ..Results are discussed relative to the monitoring season, to the spatial distribution of the response in both receiving systems, and to possible causative factors contributing to the effluent estrogenicity...
  47. ncbi Hepatic protein expression networks associated with masculinization in the female fathead minnow (Pimephales promelas)
    Christopher J Martyniuk
    Canadian Rivers Institute and Department of Biology, University of New Brunswick, Saint John, New Brunswick E2L 4L5, Canada
    J Proteome Res 11:4147-61. 2012
    ..These data provide novel insight into hepatic protein networks that are associated with the process of masculinization in teleosts...
  48. ncbi Differential expression of immune genes of adult honey bee (Apis mellifera) after inoculated by Nosema ceranae
    Veeranan Chaimanee
    Bee Protection Center, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand
    J Insect Physiol 58:1090-5. 2012
    ..Moreover, our results revealed that the mRNA levels of eater and vitellogenin did not differ significantly following N. ceranae inoculation. Therefore, in this study we reaffirmed that N. ceranae infection induces host immunosuppression...
  49. pmc Social reversal of immunosenescence in honey bee workers
    Gro V Amdam
    School of Life Sciences, Arizona State University, P O Box 874501, Tempe, AZ 85287, USA
    Exp Gerontol 40:939-47. 2005
    ..The results presented here, consequently, reveal a unique flexibility in honey bee immunity--a regulatory plasticity that may be of general biological interest...
  50. pmc Mechanisms of stable lipid loss in a social insect
    Seth A Ament
    Neuroscience Program, University of Illinois, Urbana, IL 61801, USA
    J Exp Biol 214:3808-21. 2011
    ..These results demonstrate that conserved molecular pathways can be manipulated to achieve stable lipid loss through evolutionarily novel regulatory processes...
  51. ncbi Functional characterization of the promoter of the vitellogenin gene, AsVg1, of the malaria vector, Anopheles stephensi
    Xavier Nirmala
    Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California, Irvine, CA 92697 3900, USA
    Insect Biochem Mol Biol 36:694-700. 2006
    ..These data indicate that the AsVg1 promoter is a good candidate for controlling the expression of anti-pathogen effector molecules in this malaria vector mosquito...
  52. pmc Molecular analysis of nutritional and hormonal regulation of female reproduction in the red flour beetle, Tribolium castaneum
    R Parthasarathy
    Department of Entomology, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    Insect Biochem Mol Biol 41:294-305. 2011
    ....
  53. ncbi Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow
    Gerald T Ankley
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 22:1350-60. 2003
    ..Given the widespread use of trenbolone acetate as a growth promoter, and relative stability of its metabolites in animal wastes, further studies are warranted to assess potential ecological risk...
  54. pmc Downregulation of vitellogenin gene activity increases the gustatory responsiveness of honey bee workers (Apis mellifera)
    Gro V Amdam
    Arizona State University, School of Life Sciences, Tempe, AZ 85287 4501, USA
    Behav Brain Res 169:201-5. 2006
    ..Our observations suggest that vitellogenin is an important regulator of long-term changes in honey bee behavior...
  55. ncbi Target of rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito
    Immo A Hansen
    Department of Entomology and Institute for Integrative Genome Biology, University of California, Riverside, California 92521, USA
    J Biol Chem 280:20565-72. 2005
    ..Our data show that TOR-dependent activation of S6 kinase is a central step in the transduction of nutritional information during egg development in mosquitoes...
  56. pmc Variation in endocrine signaling underlies variation in social life history
    Gro V Amdam
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287, USA
    Am Nat 170:37-46. 2007
    ..We conclude that variation in endocrine pathways of solitary origin can underlie variation and evolvability of complex social life-history traits...
  57. ncbi Identification and characterization of proteases involved in specific proteolysis of vitellogenin and yolk proteins in salmonids
    Naoshi Hiramatsu
    Division of Marine Bioscience, Graduate School of Fisheries Science, Hokkaido University, Hakodate, Hokkaido 041 8611, Japan
    J Exp Zool 292:11-25. 2002
    ..These results demonstrate, for the first time, that a cathepsin D-like protease and serine proteases play key roles in yolk formation and degradation, respectively, in salmonid fishes...
  58. pmc Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family
    H Bujo
    Department of Molecular Genetics, Biocenter, Vienna, Austria
    EMBO J 13:5165-75. 1994
    ..Its key role in avian reproduction and extremely high evolutionary conservation shed new light on VLDLR function in mammals, which also express the gene in ovaries...
  59. ncbi Vitellogenin, zona radiata protein, cathepsin D and heat shock protein 70 as biomarkers of exposure to xenobiotics
    F Maradonna
    Dipartimento di Scienze del Mare, Universita Politecnica delle Marche, Via Brecce Bianche, Ancona, Italy
    Biomarkers 12:240-55. 2007
    ....
  60. pmc Reproductive protein protects functionally sterile honey bee workers from oxidative stress
    Siri Christine Seehuus
    Department of Animal and Aquacultural Sciences, Microscopy Division, Norwegian University of Life Sciences, N 1432 As, Norway
    Proc Natl Acad Sci U S A 103:962-7. 2006
    ..This perspective is of considerable relevance to research on longevity regulation that builds largely on inference from solitary model species...
  61. ncbi The vitellogenin of the honey bee, Apis mellifera: structural analysis of the cDNA and expression studies
    M D Piulachs
    Department of Physiology and Molecular Biodiversity, Institut de Biologia Molecular de Barcelona CSIC, Jordi Girona 18, 08034 Barcelona, Spain
    Insect Biochem Mol Biol 33:459-65. 2003
    ..The deduced amino acid sequence shows significant similarity with other hymenopteran vitellogenins (58% with Pimpla nipponica and 54% with Athalia rosae)...
  62. pmc Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus
    Heli Havukainen
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Aas, Norway
    J Exp Biol 214:582-92. 2011
    ..Our experiments advance the molecular understanding of vitellogenin, of which the multiple physiological and behavioral effects in honeybees are well established...
  63. ncbi Linkage of biochemical responses to population-level effects: a case study with vitellogenin in the fathead minnow (Pimephales promelas)
    David H Miller
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Grosse Ile, Michigan 48138, USA
    Environ Toxicol Chem 26:521-7. 2007
    ..2% of the preexposed population. Overall, the current study provides an example of how changes in a biomarker (VTG concentration) can be quantitatively translated into adverse effects at the individual and population levels...
  64. ncbi Description and evaluation of a short-term reproduction test with the fathead minnow (Pimephales promelas)
    G T Ankley
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 20:1276-90. 2001
    ..These studies demonstrate the utility of this short-term assay for identifying chemicals that exert reproductive toxicity through alterations in endocrine systems controlled by estrogens and androgens...
  65. ncbi Brood pheromone suppresses physiology of extreme longevity in honeybees (Apis mellifera)
    B Smedal
    Department of Chemistry, Biotechnology and Food Science, University of Life Sciences, P O Box 5003, N 1432 Aas, Norway
    J Exp Biol 212:3795-801. 2009
    ..These findings indicate that molecular systems of extreme lifespan regulation are integrated with the sensory system of honeybees to respond to variation in a primer pheromone secreted from larvae...
  66. pmc Is vitellogenin an ancestor of apolipoprotein B-100 of human low-density lipoprotein and human lipoprotein lipase?
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093
    Biochem J 255:1057-60. 1988
    ..Here it is shown that vitellogenins, including those from the invertebrates Caenorhabditis elegans and Drosophila melanogaster, contain domains ..
  67. ncbi Gal d 6 is the second allergen characterized from egg yolk
    Alvaro Amo
    Department of Allergology, Complejo Asistencial, Avda del Cid, Burgos, Spain
    J Agric Food Chem 58:7453-7. 2010
    ..Thus, a second egg yolk allergen has been described and designated Gal d 6 by the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) Allergen Nomenclature Subcommittee...
  68. ncbi Combined biological and chemical assessment of estrogenic activities in wastewater treatment plant effluents
    Hans Rudolf Aerni
    Swiss Federal Institute for Environmental Science and Technology EAWAG, Ueberlandstrasse 133, P O Box 611, 8600 Dubendorf, Switzerland
    Anal Bioanal Chem 378:688-96. 2004
    ..Measured and calculated estradiol equivalents gave the same order of magnitude and correlated rather well (R(2)=0.6)...
  69. ncbi Annual and seasonal evaluation of reproductive status in hornyhead turbot at municipal wastewater outfalls in the Southern California Bight
    Kristy L Forsgren
    University of California, Riverside, Riverside, CA, USA
    Environ Toxicol Chem 31:2701-10. 2012
    ....
  70. ncbi Molecular characterization of a cDNA encoding vitellogenin in the banana shrimp, Penaeus (Litopenaeus) merguiensis and sites of vitellogenin mRNA expression
    Pharima Phiriyangkul
    Department of Biochemistry, Faculty of Science, Prince of Songkla University, Songkla, Thailand
    Mol Reprod Dev 73:410-23. 2006
    ..These results indicate that the Vg gene may be expressed only by mature P. merguiensis females and that both the ovary and hepatopancreas are possible sites for Vg synthesis in this species of shrimp...
  71. ncbi Drosophila yolk protein produced in E. coli is accumulated by mosquito ovaries
    M Bownes
    Institute of Cell and Molecular Biology, The University of Edinburgh, Edinburgh, UK
    Insect Mol Biol 11:487-96. 2002
    Despite similar functions, the yolk proteins of the higher dipteran flies and the vitellogenins found in other insects are unrelated at the sequence level and have evolved from different genes...
  72. ncbi Social pleiotropy and the molecular evolution of honey bee vitellogenin
    Heli Havukainen
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, PO Box 5003 1432 Aas, Norway
    Mol Ecol 20:5111-3. 2011
    ..show that the vitellogenin gene is under strong positive selection in honey bees. Rapid change has taken place in specific protein regions, shedding light on the evolution of novel vitellogenin functions...
  73. ncbi Atlantic salmon (Salmo salar L.) serum vitellogenin neutralises infectivity of infectious pancreatic necrosis virus (IPNV)
    Jose Garcia
    Facultad de Veterinaria, Universidad Complutense de Madrid, Avda Puerta de Hierro s n, 28040 Madrid, Spain
    Fish Shellfish Immunol 29:293-7. 2010
    ..The results may explain why IPNV is difficult to detect by culture methods in ovarian fluid and egg homogenates from carrier mature females and suggest a possible means of vertical transmission via the egg...
  74. pmc Vitellogenin gene expression in autogenous Culex tarsalis
    K N Provost-Javier
    The W Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Insect Mol Biol 19:423-9. 2010
    ..Vitellogenin transcript, primarily produced from the Vg1b gene, was also detected in the larval and pupal stages of development, but no detectable vitellogenin protein was produced during this time period...
  75. ncbi Vitellogenin induction as a biomarker of exposure to estrogenic compounds in aquatic environments
    Maria Gabriella Marin
    Department of Biology, University of Padova, Via Ugo Bassi 58 B, Padova 35131, Italy
    Mar Pollut Bull 48:835-9. 2004
  76. ncbi Sexual phenotype and vitellogenin synthesis in Drosophila melanogaster
    J H Postlethwait
    Dev Biol 79:379-87. 1980
  77. ncbi Purification and identification of a second form of vitellogenin from ascites of medaka (Oryzias latipes) treated with estrogen
    Munetaka Shimizu
    School of Aquatic and Fishery Sciences, Box 355020, University of Washington, Seattle, Washington 98195, USA
    J Exp Zool 293:726-35. 2002
    ..87). We thus conclude that YRP is a second form of medaka Vg and rename YRP as Vg 2 while formerly reported Vg as Vg 1...
  78. ncbi Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?
    Bernd W Brandt
    Section of Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, The Netherlands
    Bioessays 27:339-46. 2005
    ..Here, the vitellogenin family emerges as a potential key connection between lipid metabolism and the insulin/IGF-1 signalling pathway...
  79. ncbi Precursor structure of egg proteins in the coral Galaxea fascicularis
    Hideki Hayakawa
    Division of Molecular Marine Biology, Department of Marine Bioscience, Ocean Research Institute, The University of Tokyo, 1 15 1 Minamidai, Nakano, Tokyo 164 8639, Japan
    Biochem Biophys Res Commun 344:173-80. 2006
    ..The precursor protein contained regions which exhibited similarities to vitellogenins (Vgs) in bilaterian animals (oviparous vertebrates and invertebrates including nematodes, arthropods, and ..
  80. pmc Health effects in fish of long-term exposure to effluents from wastewater treatment works
    Katherine E Liney
    Environmental and Molecular Fish Biology Group, School of Biosciences, Hatherly Laboratories, The University of Exeter, Exeter, United Kingdom
    Environ Health Perspect 114:81-9. 2006
    ..They also suggest that for some effluents, genotoxic and immune end points may be more sensitive than estrogenic (endocrine-mediated) end points as indicators of exposure in fish...
  81. ncbi Vitellogenin of the Chilean flounder Paralichthys adspersus as a biomarker of endocrine disruption along the marine coast of the South Pacific. Part I: induction, purification, and identification
    Maritza Leonardi
    PIMEX ARAUCO Program, Faculty of Natural Sciences and Oceanography, University of Concepcion, Concepcion, Chile
    Fish Physiol Biochem 36:757-65. 2010
    ..Finally, we discuss the potential use of this molecule as a biomarker for the presence of xeno-estrogenic compounds along the Chilean coastline...
  82. doi Identification of vitellogenin as an allergen in Beluga caviar allergy
    M Perez-Gordo
    Allergy Department, Fundacion Jimenez Diaz, Av Reyes Católicos, 2 28040 Madrid, Spain
    Allergy 63:479-80. 2008
  83. pmc Oosorption in the endoparasitoid, Pteromalus puparum
    Jian yang Guo
    State Key Laboratory of Rice Biology, Institute of Insect Sciences, Zhejiang University, Hangzhou, 310029, China
    J Insect Sci 11:90. 2011
    ..It was assumed that once oosorption was induced in P. puparum, vitellin in the oocytes was transported outside and released into the hemolymph. This information helps to elucidate a mechanism of oosorption in insects...
  84. ncbi Impacts of 17beta-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio)
    F Brion
    Cemagref, Laboratoire d Ecotoxicologie, 3 bis quai Chauveau, CP 220, 69336 Lyon Cedex 09, France
    Aquat Toxicol 68:193-217. 2004
    ..The data presented raise further concerns about the effects of steroid estrogens in the environment on fish reproductive health...
  85. ncbi Xenopus laevis vitellogenin is a zinc protein
    M Montorzi
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA 02115
    Biochem Biophys Res Commun 200:1407-13. 1994
    ....
  86. ncbi Measurement of vitellogenin gene expression by RT-PCR as a tool to identify endocrine disruption in Japanese medaka (Oryzias latipes)
    M Islinger
    Department of Zoology, Aquatic Ecology and Toxicology Section, University of Heidelberg, Im Neuenheimer Feld 230, D 69120 Heidelberg, Germany
    Biomarkers 7:80-93. 2002
    ..therefore, initially a sequence fragment had to be obtained and compared with other known vertebrate vitellogenins. For this, a 1.2 kb cDNA of medaka vitellogenin (M-Vg1...
  87. ncbi Molecular cloning, transcriptional regulation, and differential expression profiling of vitellogenin in two wing-morphs of the brown planthopper, Nilaparvata lugens Stål (Hemiptera: Delphacidae)
    M Tufail
    Insect Science Lab, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    Insect Mol Biol 19:787-98. 2010
    ..A delayed trend in expression (of both the transcript and the protein) demonstrated by macropterous females in the present studies supports the hypothesis of prereproductive long distance migration in this wing-dimorphic species...
  88. ncbi Vitellogenin in African sharptooth catfish (Clarias gariepinus): purification, characterization, and ELISA development
    Marte Braathen
    Norwegian School of Veterinary Science, Oslo, Norway
    J Toxicol Environ Health A 72:173-83. 2009
    ..In conclusion, Vtg is induced in male C. gariepinus after exposure to both E2 and EE2, rendering it a suitable biomarker for endocrine-disrupting chemicals in African freshwater systems...
  89. pmc Sexually dimorphic transcriptomic responses in the teleostean hypothalamus: a case study with the organochlorine pesticide dieldrin
    Christopher J Martyniuk
    Department of Physiological Sciences and Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL 32611, USA
    Neurotoxicology 34:105-17. 2013
    ....
  90. ncbi Major allergen and its IgE cross-reactivity among salmonid fish roe allergy
    Yutaka Shimizu
    Faculty of Fisheries Sciences, Hokkaido University, Hokkaido, Japan
    J Agric Food Chem 57:2314-9. 2009
    ..These findings indicate that the beta'-component in salmonid roe is a common major allergen with strong IgE cross-reactivity...
  91. ncbi Molecular characterization and expression pattern of Spodoptera litura (Lepidoptera: Noctuidae) vitellogenin, and its response to lead stress
    Yinghua Shu
    State Key Laboratory of Biological Control and Institute of Entomology, Sun Yat Sen University, Guangzhou 510275, China
    J Insect Physiol 55:608-16. 2009
    ..Low levels of Vg in male adults were also induced by low concentrations of Pb (12.5 and 25 mg Pb/kg). These data show that Pb stress elicits an important Vg response in S. litura...
  92. pmc Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris venom
    Simon Blank
    Institute of Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany
    PLoS ONE 8:e62009. 2013
    ..Our aim was the identification and detailed immunochemical and allergological characterization of the low abundant IgE-reactive 200 kDa proteins of Apis mellifera and Vespula vulgaris venom...
  93. ncbi Validation of an enzyme-linked immunosorbent assay for measuring vitellogenin in California halibut (Paralichthys californicus)
    Celia Vazquez-Boucard
    Aquatic Organisms Reproduction and Toxicogenomic Laboratory, Department of Environmental Management and Conservation, Centro de Investigaciones Biologicas del Noroeste, La Paz, Baja California Sur, Mexico
    Environ Toxicol Chem 27:1614-20. 2008
    ..At Bahía Magdalena, Baja California Sur, México, quantitative measurements of VTG in the plasma of female specimens were made during one reproductive cycle...
  94. ncbi Comparison of vitellogenin responses in zebrafish and rainbow trout following exposure to environmental estrogens
    K Van den Belt
    Environmental Toxicology, Flemish Institute for Technological Research VITO, Mol B 2400, Belgium
    Ecotoxicol Environ Saf 56:271-81. 2003
    ....
  95. pmc Assessing the sensitivity of different life stages for sexual disruption in roach (Rutilus rutilus) exposed to effluents from wastewater treatment works
    Katherine E Liney
    Environmental and Molecular Fish Biology Group, School of Biosciences, Hatherly Laboratories, Exeter, United Kingdom
    Environ Health Perspect 113:1299-307. 2005
    ....
  96. ncbi Disparate binding of three types of vitellogenin to multiple forms of vitellogenin receptor in white perch
    Benjamin J Reading
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Biol Reprod 84:392-9. 2011
    ..To our knowledge, this is the first report on binding of multiple types of Vtg to multiple forms of Vtgr in any vertebrate...
  97. ncbi Effects of primary exposure to environmental and natural estrogens on vitellogenin production in carp (Cyprinus carpio) hepatocytes
    T Rouhani Rankouhi
    Institute for Risk Assessment Sciences IRAS, Utrecht University, P O Box 80176, 3508 TD, Utrecht, The Netherlands
    Toxicol Sci 67:75-80. 2002
    ..The present results indicate that weakly estrogenic environmental chemicals such as MXCL and BPA can increase the sensitivity of carp hepatocytes towards endogenous estrogens with respect to VTG synthesis...
  98. ncbi Nucleotide sequence of a chicken vitellogenin gene and derived amino acid sequence of the encoded yolk precursor protein
    F D van het Schip
    Department of Biochemistry, University of Groningen, The Netherlands
    J Mol Biol 196:245-60. 1987
    ..The main features of the gene and protein sequences, and the evolutionary implications, are discussed...
  99. ncbi Comparison of a vitellogenin gene between two distantly related rhabditid nematode species
    C E Winter
    Departamento de Parasitologia, Instituto de Ciências Biomédicas USP, Brazil
    Mol Biol Evol 13:674-84. 1996
    ..Sequence comparison shows that nematode vitellogenins are much more closely related to vertebrate than to insect vitellogenins.
  100. ncbi An enzyme-linked immunosorbent assay (ELISA) for measuring vitellogenin in English sole (Pleuronectes vetulus): development, validation and cross-reactivity with other pleuronectids
    D P Lomax
    Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, WA 98112, USA
    Comp Biochem Physiol B Biochem Mol Biol 121:425-36. 1998
    ..We are presently conducting field and laboratory studies to investigate estrogenic and anti-estrogenic activity resulting from exposure to contaminants...
  101. ncbi Endocrine effects of environmental pollution on Xenopus laevis and Rana temporaria
    C Bögi
    Department of Inland Fisheries, Leibniz Institute of Freshwater Ecology and Inland Fisheries, D 12587 Berlin, Germany
    Environ Res 93:195-201. 2003
    ....

Research Grants42

  1. Molecular Analysis of Juvenile Hormone Action
    Subba R Palli; Fiscal Year: 2013
    ....
  2. ENDOCRINOLOGY OF MOSQUITO REPRODUCTION
    ARDEN LEA; Fiscal Year: 1991
    ..e., microencapsulation and protein engineering of peptides as stomach poisons and insertion of genes for regulatory peptides in species-specific microorganisms...
  3. GENDER EFFECTS ON SUSCEPTIBILITY TO LIVER NEOPLASIA
    David Hinton; Fiscal Year: 1999
    ..Understanding the gender sensitivity of medaka to hepatocarcinogenesis may provide valuable information about gender effects on cancer formation in other vertebrates and will further characterize the medaka model. ..
  4. REGULATION OF APOLIPOPROTEIN METABOLISM--A TURTLE MODEL
    IAN CALLARD; Fiscal Year: 1993
    ..Recent evidence of sequence similarities between human apo-protein B and vertebrate vitellogenins suggests that these proteins may be the products of a gene superfamily...
  5. ESTROGEN AND VIGILIN CONTROL OF MRNA STABILITY
    David Shapiro; Fiscal Year: 2004
    ..These studies should provide new insights into a novel link between estrogen receptor action, protein synthesis rates, and the regulation of mRNA degradation. ..
  6. ALLOSTERIC REGULATION OF THE ESTROGEN RECEPTOR BY DNA
    FERN MURDOCH; Fiscal Year: 1999
    ..The results of these experiments will define the role of DNA as an allosteric effector of the estrogen receptor. ..
  7. REGULATION OF ESTROGEN-RESPONSIVE GENES
    Marilyn Evans; Fiscal Year: 2000
    ..Understanding the mechanisms by which estrogen regulates gene expression will provide a basis for understanding abnormal disease states and assisting in therapeutic design. ..
  8. HORMONE REGULATION--VITELLOGENIN & LIPOPROTEIN SYNTHESIS
    David Williams; Fiscal Year: 1990
    ..The regulation of mRNA turnover is a common strategy for modulating the expression of specific genes. The proposed research will answer several key questions about these important cellular processes...
  9. REGULATION OF VITELLOGENIC GENES IN THE MOSQUITO
    Alexander Raikhel; Fiscal Year: 2000
    ..Biochemical and biosynthetic characterization of yolk protein precursors Vg and 53KP will continue. ..
  10. ULTRASTRUCTURAL STUDIES OF DROSOPHILA DEVELOPMENT
    ANTHONY MAHOWALD; Fiscal Year: 1991
    ..Thus, I believe that a coordinated, structural, molecular, and genetic analysis of the Drosophila embryo is possible...
  11. HORMONE-INDUCED GENE EXPRESSION: OOCYTE RECONSTITUTION
    CHERYL WATSON; Fiscal Year: 1991
    ....
  12. ESTROGEN RECEPTOR REGULATED TRANSCRIPTION
    David Shapiro; Fiscal Year: 2005
    ....
  13. STUDY OF LIPID METABOLISM
    John Law; Fiscal Year: 1980
    ..All have been purified to homogeneity. Techniques to be used include sequencing methods, enzymatic degradation, lipid binding determination, radiolabeling and uptake and degradation studies. ..
  14. MOSQUITO OOCYTES--MECHANISM OF PROTEIN ACCUMULATION
    Alexander Raikhel; Fiscal Year: 1990
    ....
  15. Environmental biosensor of transgenic zebrafish
    Shuo Lin; Fiscal Year: 2005
    ....
  16. Xenoestrogen effects on reproduction in male trout
    JAMES NAGLER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  17. HUMAN FETAL LIVER GST--HYDROXYNONENAL CONJUGATION
    Evan Gallagher; Fiscal Year: 2002
    ..In addition, this project has important implications in terms of the in utero effects of pro-oxidant drugs or chemicals to which pregnant women are exposed. ..
  18. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  19. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  20. Reverse genetics of mosquito systemic immunity
    Alexander Raikhel; Fiscal Year: 2009
    ..Utilization of genetically stable dominant-negative and over-expression strains in combination with a genomic analysis of immune responses is expected to yield information about the key genes regulated by these pathways. ..
  21. Immunotoxicity of indirubin, a plant-based AhR ligand
    Charles Rice; Fiscal Year: 2005
    ..The following proposal tests the hypothesis that indirubin is a potent immunotoxic compound. ..
  22. REGULATION OF HMG-COA REDUCTASE
    DAVID BORST; Fiscal Year: 2002
    ..Finally, it seems likely that HMGR activity is regulated by neuroendocrine peptides. These studies may yield unique insights into the function and regulation of this enzyme. ..
  23. DOES PKU PROTECT AGAINST CANCER?
    Neil Sidell; Fiscal Year: 2003
    ....
  24. HSV-2 and Down-Regulations of Gap Junctions
    RICHARD WOODRUFF; Fiscal Year: 2003
    ..Furthermore, we will take advantage of these techniques to investigate specifically how the virus effects gap junctions, and how important to infectivity is closure of these channels of intercellular communication. ..
  25. PHENYLACETATE--NOVEL THERAPEUTIC USES IN BREAST CANCER
    Neil Sidell; Fiscal Year: 2005
    ..Taken together, the information gained from these studies will provide a basic framework for the rationale use of PA analogs or similar acting compounds in the clinic. ..
  26. MOSQUITO OOCYTES - MECHANISM OF PROTEIN ACCUMULATION
    Alexander Raikhel; Fiscal Year: 2001
    ..Accomplishment of these goals will significantly advance our understanding of mosquito egg development and will likely suggest applications of this knowledge in novel vector control strategies. ..