ldl lipoproteins

Summary

Summary: A class of lipoproteins responsible for transport of cholesterol to extrahepatic tissues. They are formed in the circulation when very-low-density lipoproteins are degraded first to intermediate-density lipoproteins and then to LDL by the gain and loss of specific apolipoproteins and the loss of most of their triglycerides. LDL are taken up and catabolized by both the liver and extrahepatic tissues by specific receptor-mediated endocytosis. (Dorland, 28th ed)

Top Publications

  1. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
  2. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
  3. ncbi Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes
    S Ehara
    Department of Cardiology, Osaka City General Hospital, Osaka, Japan
    Circulation 103:1955-60. 2001
  4. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
  5. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  6. ncbi Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 98:1487-94. 1998
  7. ncbi Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    Christoph J Binder
    Divisions of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0682 USA
    Nat Med 9:736-43. 2003
  8. ncbi Risk factors for cardiovascular disease in systemic lupus erythematosus
    E Svenungsson
    Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Circulation 104:1887-93. 2001
  9. ncbi An endothelial receptor for oxidized low-density lipoprotein
    T Sawamura
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 386:73-7. 1997
  10. pmc Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
    Melike Lakadamyali
    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Cell 124:997-1009. 2006

Research Grants

  1. MOLECULAR REGULATION OF APOPROTEIN B DEGRADATION
    Edward A Fisher; Fiscal Year: 2012
  2. Weight Loss &Cancer Biomarkers in Women: 0xidative Stress &Inflammation
    ANNE M MCTIERNAN; Fiscal Year: 2013
  3. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
  4. MACROPHAGE CHYLOMICRON/B48 RECEPTOR, BINDING MECHANISMS
    William Bradley; Fiscal Year: 2004
  5. ROLE OF SMOOTH MUSCLE CELLS IN GRAFT INTIMAL HYPERPLASIA
    Linda Graham; Fiscal Year: 2009
  6. Enhanced endothelialization for tissue engineering
    Kytai Nguyen; Fiscal Year: 2006
  7. ANTIATHEROGENIC ACTIONS OF OMEGA-3 FATTY ACIDS
    Papasani Subbaiah; Fiscal Year: 1990
  8. TRIAL OF BRYOSTATIN/IL-2 TO ENHANCE ANTIGEN PRESENTATION
    Paul Schwarzenberger; Fiscal Year: 2000
  9. LOW DENSITY LIPOPROTEIN IN FREE RADICAL OXIDATIVE DAMAGE
    Balaraman Kalyanaraman; Fiscal Year: 1999
  10. EXERCISE AND CARDIOVASCULAR DISEASE
    William Weintraub; Fiscal Year: 2003

Detail Information

Publications262 found, 100 shown here

  1. ncbi PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    P Tontonoz
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Cell 93:241-52. 1998
    ..These results reveal a novel signaling pathway controlling differentiation and lipid metabolism in monocytic cells, and suggest that endogenous PPARgamma ligands may be important regulators of gene expression during atherogenesis...
  2. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
    ..Thus, IL-5 links adaptive and natural immunity specific to epitopes of OxLDL and protects from atherosclerosis, in part by stimulating the expansion of atheroprotective natural IgM specific for OxLDL...
  3. ncbi Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes
    S Ehara
    Department of Cardiology, Osaka City General Hospital, Osaka, Japan
    Circulation 103:1955-60. 2001
    ..These observations suggest that increased levels of ox-LDL relate to plaque instability in human coronary atherosclerotic lesions...
  4. ncbi Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    Vidya V Kunjathoor
    Lipid Metabolism Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 277:49982-8. 2002
    ..These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence...
  5. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  6. ncbi Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 98:1487-94. 1998
    ..Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stable CAD was investigated...
  7. ncbi Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL
    Christoph J Binder
    Divisions of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0682 USA
    Nat Med 9:736-43. 2003
    ..These studies show molecular mimicry between epitopes of oxLDL and S. pneumoniae and indicate that these immune responses can have beneficial effects...
  8. ncbi Risk factors for cardiovascular disease in systemic lupus erythematosus
    E Svenungsson
    Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
    Circulation 104:1887-93. 2001
    ..We determined the prevalence of traditional and nontraditional risk factors for CVD in SLE patients with and without CVD compared with controls...
  9. ncbi An endothelial receptor for oxidized low-density lipoprotein
    T Sawamura
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Nature 386:73-7. 1997
    ..The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs...
  10. pmc Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
    Melike Lakadamyali
    Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Cell 124:997-1009. 2006
    ..This pre-early endosome sorting process begins at clathrin-coated vesicles, depends on microtubule-dependent motility, and appears to involve endocytic adaptors...
  11. ncbi Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo
    A D Watson
    Department of Medicine, Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095 1679, USA
    J Biol Chem 272:13597-607. 1997
    ..Overall, these studies suggest that specific oxidized derivatives of arachidonic acid-containing phospholipids may be important initiators of atherogenesis...
  12. ncbi Metabolic origins and clinical significance of LDL heterogeneity
    Kaspar K Berneis
    Donner Laboratory, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    J Lipid Res 43:1363-79. 2002
    ..Future delineation of the determinants of heterogeneity of LDL and other apoB-containing lipoproteins may contribute to improved identification and management of patients at high risk for atherosclerotic disease...
  13. ncbi Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
    ..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
  14. pmc Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins
    S Horkko
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682
    J Clin Invest 103:117-28. 1999
    ....
  15. pmc Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice
    Kathryn J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 115:2192-201. 2005
    ....
  16. ncbi Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    L Nagy
    The Salk Institute of Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Cell 93:229-40. 1998
    ..These results suggest that PPARgamma may be a key regulator of foam cell gene expression...
  17. pmc Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma
    W Palinski
    Department of Medicine, University of California, San Diego 92093, USA
    J Clin Invest 98:800-14. 1996
    ..The availability of "natural" monoclonal autoantibodies should facilitate the identification of specific epitopes inducing this response...
  18. ncbi Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells
    Yury I Miller
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 278:1561-8. 2003
    ....
  19. ncbi Circulating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen
    Kazuko Kobayashi
    Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Lipid Res 44:716-26. 2003
    ..Further, these same Abs correlated with IgG immune complexes containing beta2-GPI or LDL. Thus, the beta2-GPI-oxLDL complexes acting as an autoantigen are closely associated with autoimmune-mediated atherogenesis...
  20. ncbi The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide
    L Cominacini
    Department of Biomedical and Surgical Sciences, Verona University, 37134 Verona, Italy
    J Biol Chem 276:13750-5. 2001
    ..The results of this study show that one of the pathophysiological consequences of ox-LDL binding to LOX-1 may be the inactivation of NO through an increased cellular production of O(2)...
  21. ncbi Atherogenic lipoprotein particles in atherosclerosis
    Rafael Carmena
    Department of Endocrinology and Nutrition, Facultad de Medicina y Hospital Clinico Universitario, Valencia, Spain
    Circulation 109:III2-7. 2004
    ..Ultimately, better understanding of the roles of these lipid particles and subfractions in the initiation and progression of atherosclerosis may affect treatment decisions...
  22. ncbi Antibodies of IgM subclass to phosphorylcholine and oxidized LDL are protective factors for atherosclerosis in patients with hypertension
    Jun Su
    Center of Infectious Medicine and Unit of Rheumatology, F 59 Department of Medicine, Karolinska University Hospital, Huddinge, Stockholm 141 86, Sweden
    Atherosclerosis 188:160-6. 2006
    ..To determine the importance of antibodies against phosphorylcholine (PC) and oxidized low density lipoprotein (OxLDL) for development of atherosclerosis...
  23. ncbi Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events
    Sotirios Tsimikas
    Division of Cardiovascular Diseases, University of California, San Diego, CA, USA
    J Lipid Res 48:425-33. 2007
    ..In conclusion, IgG and IgM OxLDL biomarkers have divergent associations with CAD in univariate analysis but are not independent predictors of CAD or clinical events...
  24. ncbi C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients
    Sotirios Tsimikas
    Department of Medicine, Division of Cardiology, University of California, San Diego, San Diego, California 92093 0682, USA
    J Am Coll Cardiol 47:C19-31. 2006
    ....
  25. ncbi A specific ligand for beta(2)-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages
    K Kobayashi
    Department of Cell Chemistry, Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700-8558, Japan
    J Lipid Res 42:697-709. 2001
    ..We suggest that autoimmune atherogenesis linked to beta(2)-GPI interaction with oxLDL and Abs may be present in APS...
  26. ncbi Investigation of low density lipoprotein subfractions as a coronary risk factor in normotriglyceridaemic men
    I Rajman
    Department of Medicine, Queen Elizabeth Hospital Birmingham, UK
    Atherosclerosis 125:231-42. 1996
    ..LDL score was significantly correlated with CAD, even after adjusting for triglyceride and HDL cholesterol concentrations and it was the best discriminant factor for the presence of CAD...
  27. ncbi Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes
    Sotirios Tsimikas
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, BSB 1080, La Jolla, CA 92093 0682, USA
    J Am Coll Cardiol 41:360-70. 2003
    ..This study was conducted to test the hypothesis that plasma markers of oxidized low-density lipoprotein (OxLDL) reflect acute coronary syndromes (ACS)...
  28. ncbi Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis
    Maureen McMahon
    University of California at Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Arthritis Rheum 54:2541-9. 2006
    ..This study was undertaken to determine whether patients with SLE, who have chronic inflammation that causes oxidative damage, have more proinflammatory HDL and higher levels of ox-LDL, thus predisposing them to atherosclerosis...
  29. ncbi LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases
    R H Boger
    Institute of Clinical Pharmacology, Hannover Medical School, Germany
    Circ Res 87:99-105. 2000
    ..These findings suggest a novel mechanism by which ADMA concentration is elevated in hypercholesterolemia, leading to endothelial dysfunction and atherosclerosis...
  30. ncbi Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization
    T J Knott
    Science 230:37-43. 1985
    ..The apo-B100 gene is expressed primarily in liver and, to a lesser extent, in small intestine, but in no other tissues. The gene for apo-B100 is located in the p24 region (near the tip of the short arm) of chromosome 2...
  31. pmc Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women
    Samia Mora
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue E, Boston, MA 02215, USA
    Circulation 119:931-9. 2009
    ..Nuclear magnetic resonance (NMR) spectroscopy measures the number and size of lipoprotein particles instead of their cholesterol or triglyceride content, but its clinical utility is uncertain...
  32. ncbi OxLDL immune complexes activate complement and induce cytokine production by MonoMac 6 cells and human macrophages
    Antonio F Saad
    Ralph H Johnson Department of Veterans Affairs Medical Center, Charleston, SC, USA
    J Lipid Res 47:1975-83. 2006
    ..In conclusion, human OxLDL-ICs have proinflammatory properties, as reflected by their capacity to activate the classical pathway of complement and to induce proinflammatory cytokine release from MM6 cells and primary human macrophages...
  33. ncbi Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice
    T Hayek
    Lipid Research Laboratory, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Israel
    Biochem Biophys Res Commun 201:1567-74. 1994
    ....
  34. ncbi Analytical performance and diagnostic accuracy of immunometric assays for the measurement of circulating oxidized LDL
    Paul Holvoet
    Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium
    Clin Chem 52:760-4. 2006
    ....
  35. ncbi Inhibition of atherosclerosis in apoE-null mice by immunization with apoB-100 peptide sequences
    Gunilla Nordin Fredrikson
    Department of Medicine, Malmo University Hospital, Lund University, Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:879-84. 2003
    ..Immunization of animals with oxidized LDL results in reduction of atherosclerosis, suggesting an atheroprotective effect of this immune response...
  36. ncbi Triacylglycerol-rich lipoproteins and the generation of small, dense low-density lipoprotein
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Biochem Soc Trans 31:1066-9. 2003
    ..Statins remove VLDL particles via receptor-mediated pathways and reduce the residence time (and hence limit the potential for remodelling) of LDL in the circulation...
  37. ncbi Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages
    Cameron R Stewart
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Biochemistry 44:9108-16. 2005
    ....
  38. ncbi Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation
    E Lutgens
    Department of Pathology, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    Circulation 113:98-107. 2006
    ....
  39. ncbi Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential
    Vicent Ribas
    Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Circ Res 95:789-97. 2004
    ..Further, the displacement of PON1 by apoA-II could explain in part why PON1 is mostly found in HDL particles with apoA-I and without apoA-II, as well as the poor antiatherogenic properties of apoA-II-rich HDL...
  40. ncbi Mechanisms for oxidizing low-density lipoprotein. Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis
    J P Gaut
    Department of Medicine, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, Missouri, USA
    Trends Cardiovasc Med 11:103-12. 2001
    ..The implications of recent clinical trials of vitamin E for the oxidation hypothesis are also briefly discussed...
  41. ncbi Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study
    Sekar Kathiresan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    Circulation 113:20-9. 2006
    ..However, the atherogenic potential of LDL may depend on the number and size of LDL particles in addition to the cholesterol content of LDL...
  42. ncbi Short- and long-term elevation of autoantibody titers against oxidized LDL in patients with acute coronary syndromes. Role of the lipoprotein-associated phospholipase A2 and the effect of atorvastatin treatment
    Athanasios I Papathanasiou
    Department of Cardiology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
    Atherosclerosis 196:289-97. 2008
    ..Early atorvastatin treatment prevents both immune responses; however, the clinical significance of this effect remains to be established...
  43. ncbi Structure of apolipoprotein B-100 in low density lipoproteins
    J P Segrest
    Department of Medicine, 630 Boshell Bldg, 3, UAB Medical Center, Birmingham, AL 35294 0012, USA
    J Lipid Res 42:1346-67. 2001
    ....
  44. ncbi LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)
    Samia Mora
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Atherosclerosis 192:211-7. 2007
    ..Previous studies showing that smaller low-density lipoprotein (LDL) size is associated with greater atherosclerotic risk did not adequately control for small and large LDL particle correlation...
  45. pmc Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100
    J Boren
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141 9100, USA
    J Clin Invest 101:1084-93. 1998
    ..Moreover, the loss of arginine at this site destabilizes this interaction, resulting in receptor-binding defective LDL...
  46. ncbi Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells
    J L Mehta
    Department of Internal Medicine, Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, 4301 West Markham St, 532, Little Rock, AR 72205 7199, USA
    Cardiovasc Res 64:243-9. 2004
    ..We hypothesized that aspirin may interfere with LOX-1 expression and subsequent MMP activation...
  47. ncbi The small, dense LDL phenotype and the risk of coronary heart disease: epidemiology, patho-physiology and therapeutic aspects
    B Lamarche
    Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Diabetes Metab 25:199-211. 1999
    ....
  48. ncbi Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men
    M S Linna
    Department of Physiology, Sports Medical Research Unit, Paavo Nurmi Center, University of Turku, Turku, Finland
    Int J Obes (Lond) 31:245-53. 2007
    ..We studied the association between weight maintenance, oxidized low-density lipoprotein (ox-LDL) and other lipoproteins in obese men...
  49. pmc Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Leiden, The Netherlands
    Am J Pathol 165:785-94. 2004
    ..It thus appears that, depending on the stage of atherosclerotic lesion development, SR-BI in bone marrow-derived cells is either pro-atherogenic or anti-atherogenic, indicating a unique dual role in the pathogenesis of atherosclerosis...
  50. ncbi Beyond cholesterol: the enigma of atherosclerosis revisited
    Sucharit Bhakdi
    Institute of Medical Microbiology and Hygiene, Hochhaus am Augustusplatz, 55101 Mainz, Germany
    Thromb Haemost 91:639-45. 2004
    ..Detrimental effects are then evoked primarily by the unreigned activation of complement, macrophages, and other effectors of the immune system in the lesions...
  51. pmc Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    S Ishibashi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    J Clin Invest 92:883-93. 1993
    ....
  52. ncbi Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis
    D M Shih
    Division of Cardiology, Department of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 275:17527-35. 2000
    ..These data demonstrate that PON1 deficiency promotes LDL oxidation and atherogenesis in apoE KO mice...
  53. ncbi CD36 is a receptor for oxidized low density lipoprotein
    G Endemann
    Scios Nova Inc, Mountain View, California 94043
    J Biol Chem 268:11811-6. 1993
    ..CD36 may play a role in scavenging LDL modified by oxidation and may mediate effects of OxLDL on monocytes and platelets in atherosclerotic lesions...
  54. ncbi Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position
    G Subbanagounder
    Department of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 20:2248-54. 2000
    ....
  55. pmc Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice
    M Raabe
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Clin Invest 103:1287-98. 1999
    ..We conclude that MTP is essential for transferring the bulk of triglycerides into the lumen of the ER for VLDL assembly and is required for the secretion of apo B-100 from the liver...
  56. ncbi The hepatitis B virus X protein inhibits secretion of apolipoprotein B by enhancing the expression of N-acetylglucosaminyltransferase III
    Sung Koo Kang
    National Research Laboratory for Glycobiology, and Department of Biochemistry and Molecular Biology, College of Oriental Medicine, Dongguk University, Sukjang dong 707, Kyungju City, Kyungbuk 780 714, Korea
    J Biol Chem 279:28106-12. 2004
    ....
  57. ncbi High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial
    Sotirios Tsimikas
    Vascular Medicine Program, Department of Medicine, University of California San Diego, 9500 Gilman Dr, BSB 1080, La Jolla, CA 92093 0682, USA
    Circulation 110:1406-12. 2004
    ..This study evaluated the impact of atorvastatin on oxidized LDL (OxLDL) in patients with acute coronary syndromes (ACS)...
  58. ncbi Role of oxidized LDL in atherosclerosis
    T Kita
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, Japan
    Ann N Y Acad Sci 947:199-205; discussion 205-6. 2001
    ..In this paper the significance of oxidized LDL and its receptors, LOX-1 and SR-PSOX, in terms of atherogenesis is discussed...
  59. ncbi Lysosomal enzymes are released from cultured human macrophages, hydrolyze LDL in vitro, and are present extracellularly in human atherosclerotic lesions
    Jukka K Hakala
    Wihuri Research Institute, Helsinki, Finland
    Arterioscler Thromb Vasc Biol 23:1430-6. 2003
    ..However, little is known about the hydrolytic enzymes in the arterial intima that induce fusion of LDL particles and so produce lipid droplets or that induce foam cell formation...
  60. ncbi Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, Paris, France
    Arterioscler Thromb Vasc Biol 23:1881-8. 2003
    ..The relationship of the structural and functional heterogeneity of HDL particles to protection of LDL against oxidative stress is indeterminate...
  61. ncbi Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families
    Ming Lin Liu
    Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    Stroke 33:1255-60. 2002
    ....
  62. ncbi The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 45:993-1007. 2004
    ..Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides may both promote a reduction in oxidized lipids and enhance reverse cholesterol transport and therefore may have therapeutic potential...
  63. ncbi LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells
    Dayuan Li
    Department of Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock 72205, USA
    Circulation 107:612-7. 2003
    ..This study was designed to examine the role of LOX-1 in the modulation of metalloproteinases (MMP-1 and MMP-3) in human coronary artery endothelial cells (HCAECs)...
  64. ncbi NADPH oxidase in endothelial cells: impact on atherosclerosis
    Uwe Rueckschloss
    Institute of Pathophysiology, Faculty of Medicine, Martin Luther University Halle Wittenberg, Magdeburger Strasse 18, D 06097 Halle, Germany
    Antioxid Redox Signal 5:171-80. 2003
    ..Future directions of research for a better understanding of the role of NADPH oxidase in the pathogenesis of atherosclerosis and clinical implications are discussed...
  65. ncbi Disparate LDL phenotypic classification among 4 different methods assessing LDL particle characteristics
    Wayne Ensign
    Naval Health Research Center, San Diego, CA, USA
    Clin Chem 52:1722-7. 2006
    ....
  66. ncbi Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial
    James D Otvos
    LipoScience, Inc, Raleigh, NC, USA
    Circulation 113:1556-63. 2006
    ..We examined whether measurement of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle subclasses provides additional information relative to CHD risk reduction...
  67. ncbi Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    Bela F Asztalos
    Lipid Metabolism Laboratory, HNRCA, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 25:2185-91. 2005
    ....
  68. ncbi Oxidation of LDL, atherogenesis, and apoptosis
    Claudio Napoli
    Department of Medicine, University of Naples, Naples, Italy
    Ann N Y Acad Sci 1010:698-709. 2003
    ..When the precise role of oxLDL in vascular programmed cell death occurring in vivo is clarified, this may aid in the development of novel therapeutic approaches to adverse atherogenesis and its clinical sequelae...
  69. ncbi Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9
    Khadija Ouguerram
    INSERM U 539, Centre de Recherche en Nutrition Humaine de Nantes, France
    Arterioscler Thromb Vasc Biol 24:1448-53. 2004
    ..Our aim was to define the metabolic bases of this new form of hypercholesterolemia...
  70. ncbi A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid
    L Dai
    Inflammation Research Group, London Hospital Medical College, University of London, UK
    Free Radic Biol Med 22:705-10. 1997
    ..Thus, in addition to native LDL, a second form of LDL was shown to be present in rheumatoid synovial fluid, which had properties consistent with those of oxidized LDL...
  71. ncbi Anti-oxidized low-density-lipoprotein (OxLDL) antibodies in systemic lupus erythematosus with and without antiphospholipid syndrome
    G Hayem
    Hĵpital Bichat, Paris, France
    Lupus 10:346-51. 2001
    ..224; P = 0.026). AntiOxLDL elevation was found in 17% of SLE patients and was significantly associated with II APLS and venous thrombosis. We found no evidence suggesting that antiOxLDL may be associated with atherosclerosis...
  72. ncbi Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species
    Xiu ping Chen
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
    Vascul Pharmacol 47:1-9. 2007
    ..These results suggest that LOX-1 mediates ox-LDL-induced apoptosis in endothelial cells and that ROS production and NADPH oxidase might play an important role in ox-LDL-induced apoptosis...
  73. ncbi The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA
    T Yamamoto
    Cell 39:27-38. 1984
    ..Transfection of simian COS cells with the human LDL receptor cDNA linked to the SV40 early promoter resulted in expression of functional cell surface receptors...
  74. pmc The oxidation ratio of LDL: a predictor for coronary artery disease
    Huiling Huang
    Department of Cardiology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, PR China
    Dis Markers 24:341-9. 2008
    ..The purpose of this study is to elucidate the sensitivity and specificity of ox-LDL and oxidation ratio of LDL in the diagnosis of coronary artery disease (CAD). For the first time, we investigated the ratio of ox-LDL to ALB(ox-LDL/ALB)...
  75. ncbi Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase
    M Essler
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Universitat Munchen, Pettenkoferstrasse 9, 80336 Munchen, Germany
    J Biol Chem 274:30361-4. 1999
    ..We suggest that inhibition of this novel cell signaling pathway of mox-LDL could be relevant for the prevention of atherosclerosis...
  76. ncbi Subendothelial retention of atherogenic lipoproteins in early atherosclerosis
    Kristina Skålén
    Wallenberg Laboratory for Cardiovascular Research, Goteborg University, Göteborg S 4345, Sweden
    Nature 417:750-4. 2002
    ..We conclude that subendothelial retention of apoB100-containing lipoprotein is an early step in atherogenesis...
  77. ncbi Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    J Lipid Res 39:777-88. 1998
    ....
  78. pmc Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2
    Yun Soo Bae
    Department of Life Sciences, Ewha Womans University, Seoul, Korea
    Circ Res 104:210-8, 21p following 218. 2009
    ..These data help explain mechanisms by which endogenous ligands, such as mmLDL, can induce TLR4-dependent, proatherogenic activation of macrophages...
  79. ncbi Human-derived anti-oxidized LDL autoantibody blocks uptake of oxidized LDL by macrophages and localizes to atherosclerotic lesions in vivo
    P X Shaw
    Department of Medicine, University of California, San Diego, La Jolla 92093-0682, USA
    Arterioscler Thromb Vasc Biol 21:1333-9. 2001
    ..Human autoantibodies to OxLDL have important biological properties that could influence the natural course of atherogenesis...
  80. ncbi The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study
    Kokoro Tsuzaki
    Department of Preventive Medicine, Clinical Research Institute for Endocrine and Metabolic Disease, National Hospital Organization Kyoto Medical Center, Kyoto, Japan
    Metabolism 56:1689-93. 2007
    ..The present findings suggest that the beta(3)-AR gene polymorphism plays a role in the genetic predisposition to increased sdLDL, independently of insulin resistance...
  81. ncbi Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells
    Florent Lalanne
    Institut National de la Santé et de la Recherche Médicale U539, Centre Hospitalier Universitaire, Hotel Dieu, Nantes, France
    J Lipid Res 46:1312-9. 2005
    ..Finally, we show that unlike PCSK9 overexpression in mice, the S127R mutation in patients led to increased VLDL apoB levels, suggesting a potential gain of function for S127R-PCSK9 in humans...
  82. ncbi Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists
    S S Davies
    Department of Pathology, Program in Human Molecular Biology and Genetics, The Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 276:16015-23. 2001
    ..Thus, certain alkyl phospholipid oxidation products in oxLDL are specific, high affinity extracellular ligands and agonists for PPARgamma that induce PPAR-responsive genes...
  83. ncbi Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis
    Xinghua Zhou
    Department of Medicine and Centre for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Circ Res 96:427-34. 2005
    ..These findings demonstrate complex roles of immune cell-cell interactions in the regulation of the atherosclerotic process and point to several possible targets in the treatment and prevention of atherosclerosis...
  84. ncbi Regulation of small dense LDL concentration in Korean and Scottish men and women
    Hong Keun Cho
    Department of Internal Medicine, Medical College, Ewha Women s University, Seoul, Republic of Korea
    Atherosclerosis 164:187-93. 2002
    ....
  85. ncbi The relationship between oxidized LDL and other cardiovascular risk factors and subclinical CVD in different ethnic groups: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Atherosclerosis 194:245-52. 2007
    ..95 mg/dl; P=0.0002). Adjustment for risk factor correlates attenuated associations with subclinical CVD (P=0.026). In conclusion, oxLDL is associated with subclinical CVD by its relationship with many cardiovascular risk factors...
  86. pmc Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syndrome
    Paul Holvoet
    Atherosclerosis and Metabolism Unit, Katholieke Universiteit Leuven, Belgium
    JAMA 299:2287-93. 2008
    ..Experimental data support the hypothesis that oxidized low-density lipoprotein (LDL) is associated with the metabolic syndrome. However, this hypothesis has not been tested in humans...
  87. ncbi Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis
    Yasushi Ishigaki
    Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan
    Circulation 118:75-83. 2008
    ..In addition, oxidized LDL (oxLDL) is suggested to play roles in the formation and progression of atherosclerosis. However, whether lowering oxLDL alone, rather than total LDL, affects atherogenesis remains unclear...
  88. pmc Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase
    Yunzhou Dong
    Harold Hamm Oklahoma Diabetes Center, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Mol Med 13:2899-910. 2009
    ..HOG-LDL may impair endothelial function by inducing calpain-mediated eNOS degradation in a ROS- and Ca(2+)-dependent manner...
  89. pmc Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse
    Y Osono
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235
    J Clin Invest 95:1124-32. 1995
    ..Changes in LDLR activity, therefore, profoundly alter the plasma LDL-C concentration but have virtually no affect on cholesterol balance across any extrahepatic organ, including the brain...
  90. ncbi Oxidized low-density lipoprotein, iron stores, and haptoglobin polymorphism
    Annelies Brouwers
    Department of Clinical Chemistry and Haematology, AZ St Jan AV Hospital, Ruddershove 10, B 8000 Bruges, Belgium
    Atherosclerosis 176:189-95. 2004
    ..In vitro experimental studies demonstrated that iron promotes free radical-induced low-density lipoprotein (LDL) oxidation...
  91. ncbi CD36 and macrophages in atherosclerosis
    Sophie Collot-Teixeira
    Cardiovascular Division, King s College, London, UK
    Cardiovasc Res 75:468-77. 2007
    ..The aim of this article is to carefully review the importance of CD36 as an essential component in the pathogenesis of atherosclerosis...
  92. ncbi Oxidized LDL-anti-oxidized LDL immune complexes and diabetic nephropathy
    D H Atchley
    Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Diabetologia 45:1562-71. 2002
    ....
  93. pmc Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
    M Febbraio
    Department of Medicine, Division of Hematology and Medical Oncology, Center of Vascular Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 105:1049-56. 2000
    ..These results support a major role for CD36 in atherosclerotic lesion development in vivo and suggest that blockade of CD36 can be protective even in more extreme proatherogenic circumstances...
  94. pmc The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice
    Piers Davenport
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre Level 5 Block E, 246 Clayton Road, Clayton, Victoria, Australia 3168
    Am J Pathol 163:1117-25. 2003
    ..05). This suggests that both Th1 and Th2 cytokines play roles throughout the development of atherosclerosis in various vascular sites in apoE(-/-) mice...
  95. ncbi Femoral plaques confound the association of circulating oxidized low-density lipoprotein with carotid atherosclerosis in a general population aged 35 to 55 years: the Asklepios Study
    Michel R Langlois
    Department of Clinical Chemistry, AZ St Jan Hospital, Ruddershove 10, B 8000, Bruges, Belgium
    Arterioscler Thromb Vasc Biol 28:1563-8. 2008
    ..In the Asklepios Study cohort of asymptomatic subjects aged 35 to 55 years, we evaluated the relationship of circulating oxLDL with subclinical atherosclerosis in the carotid and femoral arteries...
  96. ncbi Intraretinal leakage and oxidation of LDL in diabetic retinopathy
    Mingyuan Wu
    Harold Hamm Oklahoma Diabetes Center and the Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 49:2679-85. 2008
    ..The pathogenesis of diabetic retinopathy (DR) is not fully understood. Clinical studies suggest that dyslipidemia is associated with the initiation and progression of DR. However, no direct evidence supports this theory...
  97. ncbi Oxidized low-density lipoproteins accumulate in rat lung after experimental lung edema induced by alpha- naphthylthiourea (ANTU)
    Emine Yilmaz Sipahi
    Department of Pharmacology, Faculty of Medicine, Karaelmas University, 67100 Incivez Zonguldak, Turkey
    Pharmacol Res 50:585-91. 2004
    ..The potential role of oxLDL in this pathology are still under investigation...
  98. pmc Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents
    Ian R Corbin
    Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neoplasia 8:488-98. 2006
    ..Thus, Gd-labeled LDL demonstrates potential use as a targeted MRI contrast agent for in vivo tumor detection...
  99. ncbi The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease
    Sarah Dunn
    Endothelial Cell Biology Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK
    Biochem J 409:349-55. 2008
    ..LOX-1 is increasingly viewed as a vascular disease biomarker and a potential therapeutic target in heart attack and stroke prevention...
  100. ncbi Plaque rupture, lysophosphatidic acid, and thrombosis
    Arthur A Spector
    Circulation 108:641-3. 2003
  101. ncbi Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient mice
    S Tsimikas
    Division of Cardiovascular Diseases, Department of Medicine, University of California, San Diego, USA
    Arterioscler Thromb Vasc Biol 21:95-100. 2001
    ..Whether autoantibody titers to OxLDL will provide similar valuable insights into the extent of human atherosclerosis, particularly anatomic measurements of plaque burden and OxLDL content, remains to be determined...

Research Grants71

  1. MOLECULAR REGULATION OF APOPROTEIN B DEGRADATION
    Edward A Fisher; Fiscal Year: 2012
    ..abstract_text> ..
  2. Weight Loss &Cancer Biomarkers in Women: 0xidative Stress &Inflammation
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..The results of this novel study will elucidate potential mechanisms linking energy balance to cancer in women, which will aid in the development of interventions for reducing risk for several cancers. ..
  3. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
    ..These studies should reveal the mechanisms by which w3 FA supplements alter lipoprotein metabolism in HTG patients...
  4. MACROPHAGE CHYLOMICRON/B48 RECEPTOR, BINDING MECHANISMS
    William Bradley; Fiscal Year: 2004
    ..abstract_text> ..
  5. ROLE OF SMOOTH MUSCLE CELLS IN GRAFT INTIMAL HYPERPLASIA
    Linda Graham; Fiscal Year: 2009
    ....
  6. Enhanced endothelialization for tissue engineering
    Kytai Nguyen; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. ANTIATHEROGENIC ACTIONS OF OMEGA-3 FATTY ACIDS
    Papasani Subbaiah; Fiscal Year: 1990
    ....
  8. TRIAL OF BRYOSTATIN/IL-2 TO ENHANCE ANTIGEN PRESENTATION
    Paul Schwarzenberger; Fiscal Year: 2000
    ..abstract_text> ..
  9. LOW DENSITY LIPOPROTEIN IN FREE RADICAL OXIDATIVE DAMAGE
    Balaraman Kalyanaraman; Fiscal Year: 1999
    ....
  10. EXERCISE AND CARDIOVASCULAR DISEASE
    William Weintraub; Fiscal Year: 2003
    ..Not only existing markers of oxidative stress, but also novel surrogate markers, such as, plasma soluble VCAM-l, myeloperoxidase, and autoantbodies to oxidatively modified proteins will be measured. ..
  11. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2010
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  12. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  13. Proteomic Markers of Arteriosclerosis
    Iftikhar Kullo; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  14. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  15. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  16. Fats, Immune Response and Atherosclerosis
    Ngoc Anh Le; Fiscal Year: 2002
    ..In summary, the researchers should be able to demonstrate and inverse relationship between autoantibody titers and disease severity in diet-induced atherosclerosis. ..
  17. LDL Modification in Diabetic Complications
    MARGO COHEN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. Reducing Renal TGF-B in Diabetic Glomerulosclerosis
    MARGO COHEN; Fiscal Year: 2005
    ..abstract_text> ..
  19. Point-of-Care Measurement of Glycated Hemoglobin
    MARGO COHEN; Fiscal Year: 2004
    ....
  20. COMPARATIVE GENOMIC ANALYSIS OF CARDIOVASCULAR GENE REGU
    Ronald Krauss; Fiscal Year: 2003
    ..6) The establishment of an educational program for cardiovascular researchers in the use of genomic databases and tools. ..
  21. Sphingolipid signaling induced by LDL immune complexes
    Samar M Hammad; Fiscal Year: 2010
    ..abstract_text> ..
  22. Oxidation of Apolipoprotein B-100 in LDL
    Chao Yuh Yang; Fiscal Year: 2004
    ....
  23. CARDIOVASCULAR NUTRITION IN MEDICAL EDUCATION
    Scott Grundy; Fiscal Year: 2002
    ..The long term goal is to produce graduates who routinely address nutrition and exercise for cardiovascular health with their patients. ..
  24. ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINS
    Henry J Pownall; Fiscal Year: 2010
    ....
  25. Immune Reactants, Cholesterol and Atherosclerosis
    ALLISON REISS; Fiscal Year: 2006
    ..abstract_text> ..
  26. Osteoblastogenesis in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2006
    ..If hypercholesterolemia stimulates the development of calcification in the aortic valve then the use of medical therapy such as HMG CoA reductase medications may have a role in the medical therapy of calcific aortic stenosis. ..
  27. Development of Remyelinating Agents
    Feng Qiao Li; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Biochemical Heterogeneity in Morbidly Obese Women in the WHI Observational Study
    Rachel Mackey; Fiscal Year: 2008
    ..This will be the first epidemiology study to specifically focus on morbidy obesity Class III unselected for weight reduction, i.e. bariatric surgery, in black and white women. ..
  29. Oxygen Radicals 2008 Gordon Research Conference
    Stanley Hazen; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  30. Gene-Specific Responses to Exercise in Discordant Twins
    Paul Williams; Fiscal Year: 2007
    ..DNA samples will be shared with other institutions to cross-validate gene associations identified from training studies or other designs. ..
  31. AASK Cohort Study
    Otelio Randall; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
  32. Integrative genetic approaches to Atherosclerosis
    Aldons Jake Lusis; Fiscal Year: 2010
    ..In Aim 3 we utilize a series of transgenic/knockout models to test the role of genes at the locus and to validate findings from Aims 1 and 2. ..
  33. Integrating the Metabolic and Genetic Faces of Obesity
    Gerald Reaven; Fiscal Year: 2008
    ..We believe that this work will add substantially to the current gap in knowledge regarding the link between obesity and insulin-resistance, and ultimately aid in the development of novel therapeutic targets. ..
  34. MOLECULAR GENETICS OF COLOR VISION
    Samir S Deeb; Fiscal Year: 2010
    ..Selective Tr2 ligands could potentially be designed to correct abnormal phenotypes during retinal development. ..
  35. Peer Support--Congestive Heart Failure Self-Management
    MARY ELLEN HEISLER; Fiscal Year: 2009
    ..If found effective, this approach could be used to improve health outcomes among patients with other chronic conditions, such as depression, chronic pain, or diabetes. ..
  36. CRP, Diabetes, Atherothrombosis
    Ishwarlal Jialal; Fiscal Year: 2010
    ..CRP augments oxidative stress and inflammation in the diabetic milieu will eventually lead to therapies targeted at reducing inflammation and oxidative stress in diabetes and resulting in a decrease in vasculopathies ..
  37. MOLECULAR GENETICS OF COLOR VISION
    Samir Deeb; Fiscal Year: 2008
    ..This will also help in developing cell-specific gene therapy strategies. ..
  38. Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    Aldons Lusis; Fiscal Year: 2009
    ..The results will provide an enhanced understanding of the mechanisms of obesity-induced diabetes. ..
  39. Biomarkers for Complications in Type 1 Diabetes (DCCT/EDIC)
    Stanley L Hazen; Fiscal Year: 2010
    ..These analyses may give insights into whether the effects of glycemic control on the complications of diabetes are mediated through any of the proposed biomarkers. ..
  40. Proatherogenic properties of platelet fator 4
    Bruce S Sachais; Fiscal Year: 2010
    ..into the role of PF4, the most abundant protein released by activated platelets, on the development of atherosclerosis, delineate the pathways by which this occurs in vivo, and suggest potential methods to intervene in atherogenesis ..
  41. Macrophage-Derived Oxidants in Atherogenesis
    Jay Heinecke; Fiscal Year: 2008
    ..Collectively, the proposed experiments will address the role of macrophage-derived oxidants in regulating MMP activity during atherogenesis. [unreadable] [unreadable]..
  42. Mechanochemical regulation of endothelial permeability
    Konstantin Birukov; Fiscal Year: 2007
    ....
  43. Genetics of Lipoproteins in Afro-Caribbean Families
    Iva Miljkovic Gacic; Fiscal Year: 2007
    ..Our long-term goal is to dissect the genetic architecture of traditional and nuclear magnetic spectroscopy (NMR) measured lipoprotein phenotypes in extended, multi-generational families of African heritage. [unreadable] [unreadable]..
  44. FLAGELLAR POCKET OF LEISHMANIA
    David Russell; Fiscal Year: 2001
    ..abstract_text> ..
  45. AADRC -- Mechanisms of Virus-Induced Asthma
    James Gern; Fiscal Year: 2005
    ..It is proposed that these collaborative studies will provide new insight into mechanisms of respiratory-virus-induced asthma, the possible role of diminished IFN-gamma production in this process, and possibilities for new treatment...
  46. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    JANICE WAGNER; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  47. Lipid Regulation of Vascular and Bone Osteoclastogenesis
    Linda Demer; Fiscal Year: 2004
    ....
  48. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
    ..g. aggressive anti-inflammatory and/or antioxidant interventions). ..
  49. MYELOPEROXIDASE, OXIDANT STRESS AND ATHEROGENESIS
    Stanley Hazen; Fiscal Year: 2004
    ....
  50. OXIDATIVE MECHANISMS OF AAA FORMATION (COLLABORATIVE R01
    Jay Heinecke; Fiscal Year: 2002
    ..Knowledge gained through these three closely-linked studies will help advance our understanding of the molecular pathophysiology of aortic aneurysms, potentially leading to new treatment strategies. ..
  51. Mechansim of tea catechin's inhibition of angiogenesis
    Mohsen Meydani; Fiscal Year: 2003
    ..abstract_text> ..
  52. Nanoparticle delivery of antiangiogenic genes
    Gerard Lutty; Fiscal Year: 2003
    ..The goal of this proposal is to deliver genes for endogenous antiangiogenic agents to sites of ocular neovascularization. ..
  53. B-LYMPHOCYTE MEDIATED IMMUNE MECHANISMS IN ATHEROGENESIS
    Joseph Witztum; Fiscal Year: 2001
    ..These data should provide novel information on T15 B-cell mediated mechanisms in atherogenesis and for the first time characterize "neo-self" ligands to which anti-OxLDL/T15 B cells respond. ..
  54. MECHANISMS OF RENAL TUBULAR EPITHELIAL CELL INJURY
    Sudhir Shah; Fiscal Year: 2005
    ..abstract_text> ..
  55. Genetics and Regulation of Hepatic Lipase
    Samir Deeb; Fiscal Year: 2005
    ..The genetic markers would be valuable in predicting cardiovascular risk as well as response to therapy. ..
  56. Polymer Carrier for Ischemia-Inducible Gene Therapy
    David Bull; Fiscal Year: 2007
    ..abstract_text> ..
  57. Effects of Statins on AD beyond Cholesterol and Amyloid
    Ling Li; Fiscal Year: 2006
    ..abstract_text> ..
  58. SCOR IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
    Joseph Witztum; Fiscal Year: 2006
    ..These insights may lead to novel approaches to the treatment and prevention of atherosclerosis. ..
  59. Oxidation Hypothesis--Paradoxes and Pitfalls
    Sampath Parthasarathy; Fiscal Year: 2006
    ..Exercise is also recommended for other diseases such as diabetes and hypertension, diseases in which oxidative stress is also implicated. Thus the outcome of this study will have far reaching implications. ..
  60. Macrophage Death in Plaque Vulnerability
    Ira Tabas; Fiscal Year: 2005
    ..New insights in this area may suggest new therapeutic strategies to combat cardiovascular disease. ..
  61. MOLECULAR MECHANISMS OF RPE PHAGOCYTOSIS--ROLE OF CD36
    Roy Silverstein; Fiscal Year: 2002
    ..Novel strategies to diagnose and treat retinal degeneration may thus result from this work. ..
  62. Novel Therapy for Multiple Sclerosis (SBIR-Phase II)
    Feng Qiao Li; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. Urodynamic and Multiethnic Variability of Men Treated b*
    Steven Kaplan; Fiscal Year: 2005
    ..Baseline urodynamic parameters which may predict improved outcome after MIST 3. The success of various types of MIST in treating BPH in African - American, Hispanic and Caucasian men. ..
  64. Endonuclease dificiency in breast cancer progression
    Alexei Basnakian; Fiscal Year: 2006
    ..The next specific aim will be focused on functional studies to determine the role of EndoG in dedifferentiation and invasiveness of breast cancer cells in vitro (Specific Aim 2). ..
  65. Zeiss LSM510 Meta Confocal Microscope
    David Russell; Fiscal Year: 2007
    ..These data will extend ongoing, NIH-funded programs for identification of new drug targets, vaccines and adjuvants. [unreadable] [unreadable] [unreadable]..
  66. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..abstract_text> ..
  67. SPLICE VARIANTS OF THE HA RECEPTOR FOR ENDOCYTOSIS
    Edward Harris; Fiscal Year: 2005
    ..The significance of HARE isoforms is the potential to create a family of receptors that bind/internalize a host of different GAGs. ..
  68. IMMUNOBIOLOGY OF AGING
    MARC WEKSLER; Fiscal Year: 2003
    ..The influence of anti-influenza T cell clones on the immune system of young and old mice as well as the function of the anti- influenza TCR T cell clone in young and old mice will be studied. ..
  69. Plant-Based Dietry Intervention in Type 2 Diabetes
    Neal Barnard; Fiscal Year: 2004
    ..Glycosylated hemoglobin, insulin concentrations, 24-hour urinary albumin, body weight, blood pressure, serum lipids, and related cardiovascular risk factors will be measured at baseline, 22 weeks, and 74 weeks. ..
  70. Metabolism of M. tuberculosis: New Targets for MDR TB
    David Russell; Fiscal Year: 2004
    ..abstract_text> ..
  71. GLYOXYLATE SHUNT AND PARASITISM BY MYCOBACTERIUM SPP
    David Russell; Fiscal Year: 2004
    ..We will use the recombinant enzymes to screen drug libraries at GlaxoWellcome. Structural information generated by Dr. Sacchettini will be central to the development of effective inhibitors against these enzymes. ..