hdl lipoproteins

Summary

Summary: A class of lipoproteins frequently divided into HDL2 and HDL3 and the minor variant HDL1. HDL promote transport of cholesterol from extrahepatic tissue to the liver for excretion in the bile. Synthesized by the liver as discoid "nascent HDL" particles lacking a lipid core, they accumulate a core of cholesterol esters during reverse cholesterol transport and transfer them to the liver directly or indirectly via other lipoproteins. HDL also shuttle apolipoproteins C-II and E to and from triglyceride-rich lipoproteins during catabolism of the lipoproteins. Serum HDL cholesterol has been negatively correlated with premature coronary heart disease. (Dorland, 28th ed)

Top Publications

  1. ncbi Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Pharmacol Rev 58:342-74. 2006
  2. ncbi Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment
    Benjamin J Ansell
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2751-6. 2003
  3. ncbi A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 320:677-81. 2008
  4. ncbi Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
  5. ncbi High-density lipoprotein function recent advances
    Benjamin J Ansell
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Am Coll Cardiol 46:1792-8. 2005
  6. ncbi Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study
    C R Sirtori
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Milan, Italy
    Circulation 103:1949-54. 2001
  7. ncbi Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins
    A R Tall
    Division of Molecular Medicine, Department of Medicine, Columbia University, NY, USA
    J Intern Med 263:256-73. 2008
  8. ncbi Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice
    Orit Rozenberg
    Lipid Research Laboratory, Department of Anatomy and Cell Biology, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 34:774-84. 2003
  9. ncbi New insights into the regulation of HDL metabolism and reverse cholesterol transport
    Gary F Lewis
    Department of Medicine and Physiology, University of Toronto, Canada
    Circ Res 96:1221-32. 2005
  10. ncbi The structure of apolipoprotein A-I in high density lipoproteins
    W Sean Davidson
    Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45237, USA
    J Biol Chem 282:22249-53. 2007

Detail Information

Publications250 found, 100 shown here

  1. ncbi Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit, National Institute for Health and Medical Research, Hopital de la Pitie, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Pharmacol Rev 58:342-74. 2006
    ....
  2. ncbi Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment
    Benjamin J Ansell
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2751-6. 2003
    ..The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects...
  3. ncbi A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Universite Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 320:677-81. 2008
    ..Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite...
  4. ncbi Apolipoprotein L-I is the trypanosome lytic factor of human serum
    Luc Vanhamme
    Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Nature 422:83-7. 2003
    ..We propose that apoL-I is the trypanosome lytic factor of NHS, and that SRA confers resistance to lysis by interaction with apoL-I in the lysosome...
  5. ncbi High-density lipoprotein function recent advances
    Benjamin J Ansell
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Am Coll Cardiol 46:1792-8. 2005
    ..Functional characterization of HDL is a promising method for enhanced assessment of cardiovascular risk and effectiveness of risk reduction...
  6. ncbi Cardiovascular status of carriers of the apolipoprotein A-I(Milano) mutant: the Limone sul Garda study
    C R Sirtori
    Center E Grossi Paoletti, Institute of Pharmacological Sciences, University of Milano, Milan, Italy
    Circulation 103:1949-54. 2001
    ..The objective of this study was to establish whether this high-risk lipid/lipoprotein profile is associated with structural changes in the carotid arteries and heart, indicative of preclinical atherosclerosis...
  7. ncbi Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins
    A R Tall
    Division of Molecular Medicine, Department of Medicine, Columbia University, NY, USA
    J Intern Med 263:256-73. 2008
    ....
  8. ncbi Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice
    Orit Rozenberg
    Lipid Research Laboratory, Department of Anatomy and Cell Biology, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 34:774-84. 2003
    ....
  9. ncbi New insights into the regulation of HDL metabolism and reverse cholesterol transport
    Gary F Lewis
    Department of Medicine and Physiology, University of Toronto, Canada
    Circ Res 96:1221-32. 2005
    ..role that intravascular remodeling of HDL by lipid transfer factors, lipases, cell surface receptors, and non-HDL lipoproteins play in determining the ultimate metabolic fate of HDL and plasma HDL-c concentrations...
  10. ncbi The structure of apolipoprotein A-I in high density lipoproteins
    W Sean Davidson
    Department of Pathology and Laboratory Medicine, University of Cincinnati, OH 45237, USA
    J Biol Chem 282:22249-53. 2007
  11. ncbi Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey
    Sarah D de Ferranti
    Department of Cardiology, Children s Hospital, Boston, Mass 02115, USA
    Circulation 110:2494-7. 2004
    ..Metabolic syndrome (MetS) is defined by the Third Report of the Adult Treatment Panel (ATP III) using criteria easily applied by clinicians and researchers. There is no standard pediatric definition...
  12. ncbi Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
    David Perez-Morga
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 309:469-72. 2005
    ..In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed...
  13. ncbi High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications
    Aihua Wu
    Department of Anaesthesia, Beijing Hospital, Beijing 100730, PR China
    Shock 21:210-21. 2004
    ....
  14. ncbi Identification of scavenger receptor SR-BI as a high density lipoprotein receptor
    S Acton
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Science 271:518-20. 1996
    ..SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway...
  15. ncbi A receptor-mediated pathway for cholesterol homeostasis
    M S Brown
    Science 232:34-47. 1986
  16. ncbi High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases
    Chieko Mineo
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 278:9142-9. 2003
    ..These results indicate that HDL stimulates eNOS through common upstream, Src-mediated signaling, which leads to parallel activation of Akt and MAP kinases and their resultant independent modulation of the enzyme...
  17. ncbi Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential
    Vicent Ribas
    Institut de Recerca de l Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Circ Res 95:789-97. 2004
    ..Further, the displacement of PON1 by apoA-II could explain in part why PON1 is mostly found in HDL particles with apoA-I and without apoA-II, as well as the poor antiatherogenic properties of apoA-II-rich HDL...
  18. ncbi The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux
    Mira Rosenblat
    Lipid Research Laboratory, Technion Faculty of Medicine, Haifa 31096, Israel
    J Biol Chem 281:7657-65. 2006
    ....
  19. ncbi Trypanosome lytic factors: novel mediators of human innate immunity
    J Raper
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
    Curr Opin Microbiol 4:402-8. 2001
    ..The mechanism of trypanolysis is unknown; contrary to one hypothesis, TLF does not kill trypanosomes by generating oxygen radicals. However, these trypanosomes become human-infective when they express a serum-resistance-associated gene...
  20. pmc ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
    Nan Wang
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 101:9774-9. 2004
    ..ABCG1 is highly expressed in macrophages and probably mediates cholesterol efflux from macrophage foam cells to the major HDL fractions, providing a mechanism to explain the relationship between HDL levels and atherosclerosis risk...
  21. ncbi Cubilin and megalin: partners in lipoprotein and vitamin metabolism
    J L Barth
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425 2204, USA
    Trends Cardiovasc Med 11:26-31. 2001
    ..In this article, we review the state of knowledge pertaining to cubilin and megalin, emphasizing their joint roles in both lipoprotein and vitamin metabolism...
  22. ncbi Proteomic analysis of high-density lipoprotein
    Farhad Rezaee
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Proteomics 6:721-30. 2006
    ..Our approach thus resulted in the identification of a large number of proteins associated with HDL. The combination of proteomic technologies proved to be a powerful and comprehensive tool for the identification of proteins on HDL...
  23. ncbi High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Circulation 111:2805-11. 2005
    ..In addition to its role in reverse cholesterol transport, HDL influences different functions of endothelial cells. In the present study, we investigated in endothelial cells the genes involved in inflammation modulated by HDL...
  24. ncbi Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study
    A R Sharrett
    Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 104:1108-13. 2001
    ..CONCLUSIONS: Optimal LDL-C values are <100 mg/dL in both women and men. LDL-C, HDL-C, TG, and Lp(a), without additional apolipoproteins or lipid subfractions, provide substantial CHD prediction, with much higher RR in women than men...
  25. ncbi The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein
    R Kozyraki
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Nat Med 5:656-61. 1999
    ..The physiological relevance of the cubilin-apoA-I interaction was further emphasized by urinary apoA-I loss in some known cases of functional cubilin deficiency. Therefore, cubilin is a receptor in epithelial apoA-I/HDL metabolism...
  26. ncbi Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation
    G W Cockerill
    British Heart Foundation Cardiovascular Research Unit, National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    Circulation 103:108-12. 2001
    ..Our study therefore sought to test the hypothesis that elevating the level of circulating HDLs would inhibit endothelial cell activation in vivo...
  27. pmc Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death
    Guanghua Wan
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Biol Chem 283:21540-9. 2008
    ..To our knowledge, this is the first BH3-only protein with lipid binding activity that, when overproduced intracellularly, induces AuCD...
  28. ncbi Alterations of HDL subclasses in hyperlipidemia
    Yanhua Xu
    Department of Biochemistry and Apolipoprotein Research Unit, West China Medical Center, Sichuan University, Chengdu, 610041 Sichuan, People s Republic of China
    Clin Chim Acta 332:95-102. 2003
    ..HDL is known to directly influence the atherogenic process and changes in HDL subclasses distribution may be related to the incidence and prevalence of atherosclerosis...
  29. ncbi Paraoxonase-1 inhibits oxidised LDL-induced MCP-1 production by endothelial cells
    Bharti Mackness
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Biochem Biophys Res Commun 318:680-3. 2004
    ..PON1 attenuates the ox-LDL induced MCP-1 production by endothelial cells. This is one, early, mechanism by which PON1 may be anti-atherogenic...
  30. ncbi The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 45:993-1007. 2004
    ..Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides may both promote a reduction in oxidized lipids and enhance reverse cholesterol transport and therefore may have therapeutic potential...
  31. ncbi Distribution of ApoA-I-containing HDL subpopulations in patients with coronary heart disease
    B F Asztalos
    Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 20:2670-6. 2000
    ....
  32. ncbi The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue
    Houshang Monajemi
    Department of Biochemistry of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 1105 AZ
    Genomics 79:539-46. 2002
    ..Our results show that the APOL1-APOL4 cluster might contribute to the substantial differences in the lipid metabolism of humans and mice, as dictated by the variable expression of genes involved in this process...
  33. ncbi Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress
    Anatol Kontush
    Dyslipoproteinemia and Atherosclerosis Research Unit U 551, National Institute for Health and Medical Research INSERM, Hopital de la Pitie, Paris, France
    Arterioscler Thromb Vasc Biol 23:1881-8. 2003
    ..The relationship of the structural and functional heterogeneity of HDL particles to protection of LDL against oxidative stress is indeterminate...
  34. ncbi Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins
    S M Hammad
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    J Biol Chem 275:12003-8. 2000
    ..These data demonstrate that megalin acts together with cubilin to mediate HDL endocytosis and further suggest that megalin may play a role in the intracellular trafficking of cubilin...
  35. pmc ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death
    Siqin Zhaorigetu
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    Autophagy 4:1079-82. 2008
    ..Finally, we discuss the link between ApoL1 and various human diseases...
  36. pmc Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function
    W Sean Davidson
    Department of Pathobiology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45221, USA
    Arterioscler Thromb Vasc Biol 29:870-6. 2009
    ..We hypothesized that distinct clusters of protein components may distinguish between physicochemically-defined subpopulations of HDL particles, and that such clusters may exert specific biological function(s)...
  37. pmc Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
    Lemin Zheng
    Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Clin Invest 114:529-41. 2004
    ..They also suggest a potential mechanism for MPO-dependent generation of a proatherogenic dysfunctional form of HDL in vivo...
  38. ncbi S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity
    Orit Rozenberg
    The Lipid Research Laboratory, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Biochem Biophys Res Commun 351:492-8. 2006
    ..We thus conclude that HDL-associated serum PON1 can undergo S-glutathionylation under oxidative stress with a consequent reversible inactivation...
  39. ncbi The role of high-density lipoproteins in oxidation and inflammation
    B J Van Lenten
    Department of Medicine, University of California, Los Angeles, California, USA
    Trends Cardiovasc Med 11:155-61. 2001
    ..This "chameleon-like" nature of HDL is considered to be due to the complex composition of HDL. The data reviewed here demonstrate the key role of HDL in modulating inflammation and its implications for atherogenesis...
  40. ncbi Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6.4 mmol/l...
  41. ncbi HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase coupling
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 24:871-7. 2004
    ..HDLs have been shown to increase prostacyclin synthesis, thus in the present study we investigated the molecular mechanisms involved in this effect in endothelial cells...
  42. ncbi Scavenger receptor BI and cholesterol trafficking
    D L Williams
    Department of Pharmacological Sciences, University Medical Centre, State University of New York at Stony Brook, 11794, USA
    Curr Opin Lipidol 10:329-39. 1999
    ..These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people...
  43. ncbi High density lipoproteins induce cell cycle entry in vascular smooth muscle cells via mitogen activated protein kinase-dependent pathway
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Thromb Haemost 85:730-5. 2001
    ..The strong and specific mitogenic effect of HDL should be taken into account, when therapeutic strategies to elevate the plasma level of these lipoproteins are developed...
  44. ncbi Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
    D M Shih
    Division of Cardiology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095, USA
    Nature 394:284-7. 1998
    ..When fed on a high-fat, high-cholesterol diet, PON1-null mice were more susceptible to atherosclerosis than their wild-type littermates...
  45. ncbi High density lipoprotein complexes as delivery vehicles for anticancer drugs
    Andras G Lacko
    Institute for Cancer Research, Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth 76107, USA
    Anticancer Res 22:2045-9. 2002
    ..Three molecules of taxol per rHDL particle were incorporated into these rHDL complexes...
  46. pmc C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
    Laurence Lecordier
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
    PLoS Pathog 5:e1000685. 2009
    ..In addition, they provide a possible explanation for the ability of Papio serum to kill T. b. rhodesiense, and offer a perspective to generate transgenic cattle resistant to both T. b. brucei and T. b. rhodesiense...
  47. ncbi Relationship between plasma lipid concentrations and HDL subclasses
    Yuye Yang
    Apolipoprotein Research Unit, Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041 Sichuan, People s Republic of China
    Clin Chim Acta 354:49-58. 2005
    ..HDL is known to directly influence the atherogenic process and changes in HDL subclasses distribution may be related to the incidence and prevalence of atherosclerosis...
  48. ncbi Understanding changes in high density lipoproteins during the acute phase response
    Brian J Van Lenten
    Arterioscler Thromb Vasc Biol 26:1687-8. 2006
  49. ncbi Platelet-activating factor acetylhydrolase, and not paraoxonase-1, is the oxidized phospholipid hydrolase of high density lipoprotein particles
    Gopal K Marathe
    Human Molecular Biology and Genetics, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 278:3937-47. 2003
    ..We conclude that PAF acetylhydrolase is the sole phospholipase A(2) of HDL and that PON1 has no phospholipase activity toward PAF or pro-atherogenic oxidized phospholipids...
  50. ncbi Endothelial protection by high-density lipoproteins: from bench to bedside
    Laura Calabresi
    Center E Grossi Paoletti, Department of Pharmacological Sciences, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 23:1724-31. 2003
    ....
  51. ncbi Recycling of apoprotein E is associated with cholesterol efflux and high density lipoprotein internalization
    Joerg Heeren
    Institute for Medical Biochemistry and Molecular Biology, The Department of Molecular Cell Biology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Biol Chem 278:14370-8. 2003
    ..Thus, these studies provide evidence for a new intracellular link between TRL-derived apoE, cellular cholesterol transport, and HDL metabolism...
  52. ncbi Defective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes
    Maria Mastorikou
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, U K
    Diabetes 55:3099-103. 2006
    ..HDL from type 2 diabetic subjects without CHD had a decreased ability to metabolize oxidized phospholipids, which could lead to increased susceptibility to develop cardiovascular disease...
  53. ncbi High density lipoprotein-induced angiogenesis requires the activation of Ras/MAP kinase in human coronary artery endothelial cells
    Shin Ichiro Miura
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma, Jonan ku, Fukuoka, 814 0180, Japan
    Arterioscler Thromb Vasc Biol 23:802-8. 2003
    ..In this study, we investigated the role of the HDL-mediated promotion of angiogenesis in human coronary artery ECs (HCECs)...
  54. ncbi Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein
    Radjesh J Bisoendial
    Department of Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Circulation 107:2944-8. 2003
    ..In these familial hypoalphalipoproteinemia subjects, we evaluated the impact of isolated low HDL on endothelial function and the vascular effects of an acute increase in HDL...
  55. ncbi Formation and metabolism of prebeta-migrating, lipid-poor apolipoprotein A-I
    Kerry Anne Rye
    Heart Research Institute, Camperdown, Sydney, NSW, Australia
    Arterioscler Thromb Vasc Biol 24:421-8. 2004
    ..This review describes current knowledge regarding the formation, metabolism, and regulation of monomolecular, lipid-free/lipid-poor apoA-I in plasma...
  56. ncbi Insight into the mechanism of trypanosome lytic factor-1 killing of Trypanosoma brucei brucei
    J R Bishop
    Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Biochem Parasitol 118:33-40. 2001
    ..The data presented supports the hypothesis that the combination of these factors with TLF-1 inside the lysosome results in lysosomal membrane breakdown, release of the lysosomal contents, and subsequent autodigestion of the cell...
  57. pmc Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women
    Samia Mora
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue E, Boston, MA 02215, USA
    Circulation 119:931-9. 2009
    ..Nuclear magnetic resonance (NMR) spectroscopy measures the number and size of lipoprotein particles instead of their cholesterol or triglyceride content, but its clinical utility is uncertain...
  58. ncbi Composition and ultrastructure of size subclasses of normal human peripheral lymph lipoproteins: quantification of cholesterol uptake by HDL in tissue fluids
    M N Nanjee
    Department of Cardiovascular Biochemistry, St. Bartholomew's and the Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK
    J Lipid Res 42:639-48. 2001
    ..Net transport rates of new HDL cholesterol in the cannulated vessels corresponded to a mean whole body reverse cholesterol transport rate via lymph of 0.89 mmol (344 mg)/day...
  59. ncbi Involvement of transcription factors in plasma HDL protection against TNF-alpha-induced vascular cell adhesion molecule-1 expression
    Sung Hee Park
    Division of Life Sciences and Institute of Environment and Life Science, Hallym University, 1 Ockchon dong, 200 702, Kangwon Do, Chuncheon, South Korea
    Int J Biochem Cell Biol 35:168-82. 2003
    ..Plasma HDL may block the initial atherosclerotic process via inhibited monocyte adhesion to the endothelium, which is independent of modulating the cholesterol reverse transport of plasma HDL...
  60. ncbi High-density lipoprotein loses its anti-inflammatory properties during acute influenza a infection
    B J Van Lenten
    Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA
    Circulation 103:2283-8. 2001
    ..Viruses have been identified as one of a variety of potential agents that are implicated in atherogenesis...
  61. ncbi High-density lipoprotein increases intracellular calcium levels by releasing calcium from internal stores in human endothelial cells
    H M Honda
    Department of Medicine, University of California, Los Angeles 90095 1679, USA
    Atherosclerosis 143:299-306. 1999
    ..These findings suggest that HDL, like LDL, can modulate EC Ca(i) and that this occurs via a pertussis toxin-sensitive G protein-mediated pathway which involves phospholipase C...
  62. ncbi Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase
    Hema Viswambharan
    Department of Medicine, Divisions of Physiology, University of Fribourg, Fribourg, Switzerland
    Circ Res 94:918-25. 2004
    ..In conclusion, rHDL inhibits thrombin-induced human endothelial TF expression through inhibition of RhoA and activation of PI3K but not Akt/eNOS. These findings implicate a novel mechanism of antiatherothrombotic effects of HDL...
  63. ncbi African trypanosomes: intracellular trafficking of host defense molecules
    April M Shiflett
    Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA
    J Eukaryot Microbiol 54:18-21. 2007
    ..These findings indicate that the cellular distribution of TLF is influenced by SRA expression and may directly determine susceptibility...
  64. ncbi A dual role for lecithin:cholesterol acyltransferase (EC 2.3.1.43) in lipoprotein oxidation
    Peter A C McPherson
    Centre for Clinical and Population Sciences, Nutrition and Metabolism Group, The Queen s University of Belfast BT12 6BJ, Northern Ireland, UK
    Free Radic Biol Med 43:1484-93. 2007
    ..Thus, we have demonstrated that the high-density lipoprotein-associated enzyme LCAT may have a significant role to play in lipoprotein modification and hence atherogenesis...
  65. ncbi Activation of phosphatidylinositol-specific phospholipase C by HDL-associated lysosphingolipid. Involvement in mitogenesis but not in cholesterol efflux
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    Biochemistry 39:15199-207. 2000
    ..Apo A-I stimulates phosphatidylcholine breakdown and thereby facilitates cholesterol efflux, whereas LSF and SPC trigger PI-PLC activation and thereby stimulate cell proliferation...
  66. ncbi The lysosomal targeting and intracellular metabolism of trypanosome lytic factor by Trypanosoma brucei brucei
    M Shimamura
    Department of Pediatrics, Schools of Medicine and Dentistry, University of Alabama at Birmingham, 35294, Birmingham, AL, USA
    Mol Biochem Parasitol 115:227-37. 2001
    ..Results presented here indicate that TLF-1 lipoproteins are targeted to the lysosome but are resistant to trypanosome lysosomal proteases...
  67. ncbi Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases
    A Barrans
    Institut National de la Sante et de la Recherche Medicale, Hopital Purpan, Toulouse, France
    J Biol Chem 269:11572-7. 1994
    ..These results evidence the role of the triacylglycerol lipase activity of hepatic lipase in the formation of pre-beta 1 HDL from triacylglycerol-rich HDL2...
  68. ncbi Effect of weight loss on LDL and HDL kinetics in the metabolic syndrome: associations with changes in plasma retinol-binding protein-4 and adiponectin levels
    Theodore W K Ng
    School of Medicine and Pharmacology, Metabolic Research Centre, University of Western Australia, New South Wales, Australia
    Diabetes Care 30:2945-50. 2007
    ..The purpose of this study was to examine the effect of weight loss on LDL and HDL kinetics and plasma retinol-binding protein-4 (RBP-4) and adiponectin levels in men with the metabolic syndrome...
  69. pmc Characterization of a novel trypanosome lytic factor from human serum
    J Raper
    Departments of Medical and Molecular Parasitology, New York University Medical School, New York, New York 10010, USA
    Infect Immun 67:1910-6. 1999
    ..Characterization of TLF2 reveals that it is a 1,000-kDa protein complex containing mainly immunoglobulin M, apoA-I, and Hpr but less than 1% detectable lipid...
  70. ncbi Receptors and lipid transfer proteins in HDL metabolism
    D L Silver
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Ann N Y Acad Sci 902:103-11; discussion 111-2. 2000
    ..Lastly, we highlight our findings that overexpression of SR-BI in LDL receptor-deficient mice results in decreased atherosclerosis...
  71. ncbi Evidence for a Trypanosoma brucei lipoprotein scavenger receptor
    Heather P Green
    Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA
    J Biol Chem 278:422-7. 2003
    ..Based on these results we propose that HDL, LDL, and TLF1 are all bound and taken up by a lipoprotein scavenger receptor, which may constitute the parasite's major pathway mediating the uptake of essential lipids...
  72. ncbi Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells
    T Kimura
    Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8512, Japan
    J Biol Chem 276:31780-5. 2001
    ..Furthermore, the decrease in the S1P content, in addition to the accumulation of cytotoxic substances such as LPC, may be important for the acquisition of the cytotoxic property to ox-LDL...
  73. ncbi Antiinflammatory properties of HDL
    Philip J Barter
    The Heart Research Institute, 145 Missenden Rd, Camperdown, Sydney 2050, Australia
    Circ Res 95:764-72. 2004
    ..These antioxidant and antiinflammatory properties of HDL may be as important as its cholesterol efflux function in terms of protecting against the development of atherosclerosis...
  74. pmc Molecular regulation of HDL metabolism and function: implications for novel therapies
    Daniel J Rader
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    J Clin Invest 116:3090-100. 2006
    ..Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics...
  75. ncbi Efficient isolation, purification, and characterization of the Helicoverpa zea VHDL receptor
    Deryck R Persaud
    Department of Biological Sciences, Simon Fraser University, Burnaby, BC, Canada V5A 1S6
    Protein Expr Purif 32:260-4. 2003
    ..Sufficient receptor protein has been derived for amino acid analysis, receptor-ligand and xenobiotic binding studies...
  76. ncbi The importance of high-density lipoproteins for paraoxonase-1 secretion, stability, and activity
    Richard W James
    Clinical Diabetes Unit, Division of Endocrinology, Diabetes, and Nutrition, Faculty of Medicine, University Hospital, 24 Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Free Radic Biol Med 37:1986-94. 2004
    ..Finally, we highlight questions concerning the HDL-PON1 association that remain unanswered but are of particular importance in defining PON1 efficiency...
  77. ncbi Effects of insulin resistance and type 2 diabetes on lipoprotein subclass particle size and concentration determined by nuclear magnetic resonance
    W Timothy Garvey
    Division of Endocrinology and Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Diabetes 52:453-62. 2003
    ..It will be important to study whether NMR lipoprotein subclass parameters can be used to manage risk more effectively and prevent cardiovascular disease in patients with the IRS...
  78. ncbi Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL
    D Calvo
    Hospital de la Princesa, Madrid, Spain
    J Lipid Res 39:777-88. 1998
    ....
  79. pmc HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3
    Jerzy Roch Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfalische Wilhelms Universitat, Munster, Germany
    J Clin Invest 113:569-81. 2004
    ..This mechanism may contribute to the vasoactive effect of HDL and represent a novel aspect of its antiatherogenic function...
  80. ncbi The paradox of dysfunctional high-density lipoprotein
    Benjamin J Ansell
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:427-34. 2007
    ..This review addresses how, in atherosclerosis or systemic inflammation, HDL can lose its usual atheroprotective characteristics and even paradoxically assume proinflammatory properties...
  81. ncbi High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase
    I S Yuhanna
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 7:853-7. 2001
    ..Thus, HDL activates eNOS via SR-BI through a process that requires ApoA-I binding. The resulting increase in nitric-oxide production might be critical to the atheroprotective properties of HDL and ApoA-I...
  82. ncbi Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity
    A Pascot
    Lipid Research Center, CHUL Research Center, Ste-Foy, , Canada
    J Lipid Res 42:2007-14. 2001
    ..In conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia...
  83. ncbi High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
    Leonid Gaidukov
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 44:11843-54. 2005
    ..Overall, the results indicate the high stability, selectivity, and catalytic proficiency of PON1 when anchored onto apoA-I HDL, toward lactone substrates, and lipophilic lactones in particular...
  84. ncbi Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor
    Toya Nath Baral
    Department of Cellular and Molecular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Laboratorium voor Cellulaire en Moleculaire Immunologie, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Nat Med 12:580-4. 2006
    ..Treatment with this engineered conjugate resulted in clear curative and alleviating effects on acute and chronic infections of mice with both NHS-resistant and NHS-sensitive trypanosomes...
  85. ncbi Effect of glycation of high density lipoproteins on their physicochemical properties and on paraoxonase activity
    G Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy
    Acta Diabetol 38:163-9. 2001
    ..The modification of order and polarity of glycated HDL and the alterations in paraoxonase activity could potentially contribute to the accelerated atherosclerosis in diabetic patients...
  86. ncbi Influence of atorvastatin on apolipoprotein E and AI kinetics in patients with type 2 diabetes
    K Bach-Ngohou
    Institut National de la Santé et de la Recherche Médicale U539, Centre de Recherche en Nutrition Humaine, CHU Hôtel Dieu Nantes, France
    J Pharmacol Exp Ther 315:363-9. 2005
    ..The increased number of apoE per VLDL particle suggests that atorvastatin could enhance the direct catabolism of triglyceride-rich VLDL through apoE receptor pathways...
  87. ncbi Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids
    J R Nofer
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Westfälische Wilhelms Universität and the Institut für Arterioskleroseforschung an der Universität Münster, 48129 Munster, Germany
    J Biol Chem 276:34480-5. 2001
    ....
  88. ncbi Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes
    April M Shiflett
    Josephine Bay Paul Center, Global Infectious Disease Program, Marine Biological Laboratory, Woods Hole, Massachussetts 02543, USA
    J Biol Chem 280:32578-85. 2005
    ..These studies show that HDLs can serve as platforms for the assembly of multiple synergistic proteins and that these assemblies may play a critical role in the evolution of primate-specific innate immunity to trypanosome infection...
  89. ncbi Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia
    Lantu Gou
    Department of Biochemistry and Molecular Biology, West China Medical Center, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Am Heart J 150:1039-45. 2005
    ..To investigate the alterations of high-density lipoprotein (HDL) subclasses in endogenous hypertriglyceridemic subjects...
  90. ncbi Characterization of primate trypanosome lytic factors
    Elena B Lugli
    Department of Medical and Molecular Parasitology, New York University School of Medicine, 341, East 25th Street, New York, NY 10010, USA
    Mol Biochem Parasitol 138:9-20. 2004
    ..These findings suggest that apoL-I is not essential in all primate TLFs, and apoL-I alone is not sufficient for optimal trypanosome lytic activity in human TLF...
  91. ncbi The trypanosome lytic factor of human serum and the molecular basis of sleeping sickness
    Luc Vanhamme
    Department of Molecular Biology, Laboratory of Molecular Parasitology, IBMM, University of Brussels, 12, rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
    Int J Parasitol 34:887-98. 2004
    ..This research also allowed the identification of a specific diagnostic DNA probe for T. b. rhodesiense, and may lead to the development of novel anti-trypanosome strategies for use in the field...
  92. ncbi Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature
    Liisa Lauren
    Department of Epidemiology and Public Health, Imperial College London, Faculty of Medicine, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 32:862-76. 2003
    ....
  93. ncbi Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL, and HDL subfraction distribution and size in overweight men
    Richard J Wood
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr 136:384-9. 2006
    ..01). We conclude that weight loss induced by CR favorably alters the secretion and processing of plasma lipoproteins, rendering VLDL, LDL, and HDL particles associated with decreased risk for atherosclerosis and coronary heart disease...
  94. ncbi High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease
    Lucia Rohrer
    Institute of Clinical Chemistry, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Curr Opin Lipidol 15:269-78. 2004
    ....
  95. ncbi Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia
    Lianqun Jia
    Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China
    Int J Cardiol 120:331-7. 2007
    ..This study evaluates the alterations of high-density lipoprotein (HDL) subclasses in hypercholesterolemic and combined hyperlipidemic subjects...
  96. ncbi Genetic factors affecting HDL levels, structure, metabolism and function
    Dmitri Sviridov
    Baker Heart Research Institute, Melbourne, Victoria, Australia
    Curr Opin Lipidol 18:157-63. 2007
    ..The present review focuses on various approaches to establish genetic determinants of the HDL concentration, structure and function...
  97. ncbi Serum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation
    M Boemi
    Division of Diabetology, INRCA, Ancona, Italy
    Atherosclerosis 155:229-35. 2001
    ..The results are consistent with the contention that modifications to serum paraoxonase in type 1 patients can increase risk of lipoprotein oxidation and, consequently, risk of vascular disease...
  98. pmc Plasma apolipoprotein C-III transport in centrally obese men: associations with very low-density lipoprotein apolipoprotein B and high-density lipoprotein apolipoprotein A-I metabolism
    Dick C Chan
    Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, GPO Box X2213, Perth, Western Australia 6847, Australia
    J Clin Endocrinol Metab 93:557-64. 2008
    ..Plasma apoC-III is elevated in centrally obese men, and we hypothesized that the kinetics of apoC-III are disturbed in these subjects...
  99. pmc Blockade of T cell contact-activation of human monocytes by high-density lipoproteins reveals a new pattern of cytokine and inflammatory genes
    Lyssia Gruaz
    Division of Immunology and Allergy, Inflammation and Allergy Research Group, Hans Wilsdorf Laboratory, Department of Internal Medicine and Faculty of Medicine, University of Geneva, Geneva, Switzerland
    PLoS ONE 5:e9418. 2010
    ..High-density lipoproteins (HDL) specifically inhibit the production of pro-inflammatory cytokines induced by T cell contact...
  100. ncbi The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction
    Zhiping Wu
    Department of Cell Biology, Cleveland Clinic, 9500 Euclid Avenue, NE 10, Cleveland, Ohio 44195, USA
    Nat Struct Mol Biol 14:861-8. 2007
    ....
  101. ncbi Identification of a sequence of apolipoprotein A-I associated with the activation of Lecithin:Cholesterol acyltransferase
    D Sviridov
    Baker Medical Research Institute, Melbourne 8008 and the Department of Biochemistry, University of Melbourne, Parkville 3052, Victoria, Australia
    J Biol Chem 275:19707-12. 2000
    ....

Research Grants68

  1. Characterization and Consequences of HCV Interaction with Host Lipoproteins
    MARGARET ADELE SCULL; Fiscal Year: 2012
    ..Such analyses will provide valuable insight into the composition of the HCV particle and its life cycle. ..
  2. Lp-PLA2 and Coronary Atherosclerosis in Humans
    Amir Lerman; Fiscal Year: 2013
    ..One of the reasons is the process of inflammation in the wall of the vessel. The current application is focused on new methods to identify and treat this early process and potential prevents heart attacks and sudden death. ..
  3. MOLECULAR ASPECTS OF AMYLOIDOSIS
    WARREN LIAO; Fiscal Year: 1999
    ..to study the pathogenesis of secondary amyloidosis using a transgenic animal model. ..
  4. HIGH DENSITY LIPOPROTEIN SUBSPECIES AND CORONARY DISEASE
    Bela Asztalos; Fiscal Year: 2003
    ..The investigators state that these studies should provide better understanding about the diagnosis and treatment of HDL deficiency for the prevention of CHD. ..
  5. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ....
  6. ENZYMATIC REACTIONS OF PLASMA LIPOPROTEINS
    Henry J Pownall; Fiscal Year: 2010
    ....
  7. Gordon Research Conference: Lipoprotein Metabolism 2004
    Daniel Rader; Fiscal Year: 2004
    ....
  8. Mentored Career Development in Patient Oriented Research
    Daniel Rader; Fiscal Year: 2006
    ..abstract_text> ..
  9. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..These studies will provide novel insights into the mechanisms of PI-associated dyslipidemia and atherosclerosis. ..
  10. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  11. CELLULAR BASIS OF ANTIATHEROGENESIS BY APOLIPOPROTEIN E
    Daniel Rader; Fiscal Year: 2001
    ..These studies will provide greater understanding of the role of the local inflammatory response in atherosclerosis and its regulation by apoE. ..
  12. HDL metabolism: Influence of extracellular lipases
    Daniel Rader; Fiscal Year: 2009
    ....
  13. MOLECULAR BASIS OF HIGH DENSITY LIPOPROTEIN DEFICIENCY
    ERNST SCHAEFER; Fiscal Year: 2009
    ..The results of this work will provide important insight into the contribution of allelic variation in the pathways of HDL metabolism, inflammation, and insulin resistance to the complex phenotype of low HDL-C. ..
  14. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
  15. MOLECULAR MECHANISMS OF ASSEMBLY OF APOPB LIPOPROTEINS
    JERE SEGREST; Fiscal Year: 2001
    ..The results of specific aims 1 and 2 will determine the specific sites and types of mutations selected. ..
  16. THE ATHEROPROTECTIVE EFFECTS OF SR-BI
    Monty Krieger; Fiscal Year: 2004
    ..g., normal HDL lipoproteins, ii) altered flux of cholesterol into or out of the vessel wall, perhaps directly due to abnormal HDL ..
  17. Apolipoprotein-mediated cholesterol efflux
    W Davidson; Fiscal Year: 2008
    ..This understanding will form a basis for new interventions designed to enhance apolipoprotein-mediated cholesterol efflux from cells, particularly those within the atherosclerotic vessel wall. ..
  18. The roles of apolipoprotein A-IV structure and lipid affinity in its function
    W Davidson; Fiscal Year: 2009
    ....
  19. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    ..abstract_text> ..
  20. The Role of Tenascin in Neointimal Formation
    Prediman Shah; Fiscal Year: 2009
    ..Aim 3. TN deficiency promotes neointimal formation after vascular injury. Aim 4. TN deficiency per se is sufficient for neointimal formation. ..
  21. GENES CONTROLLING LDL RECEPTOR STRUCTURE AND FUNCTION
    Monty Krieger; Fiscal Year: 2003
    ..This should further our understanding of the complex physiologic and pathophysiologic (e.g., familial hypercholesterolemia, atherosclerosis) processes which are based on the function and dysfunction of the LDLR. ..
  22. ABCA1 agonist peptides for therapeutic use
    JOHN BIELICKI; Fiscal Year: 2008
    ..The research is likely to have a high impact on public health, since the therapeutics will be amenable to the widespread treatment of atherosclerosis. [unreadable] [unreadable] [unreadable] [unreadable]..
  23. Apo A2, C1 and C2 and Diet in human apoB Metabolism
    Frank Sacks; Fiscal Year: 2005
    ..abstract_text> ..
  24. Mechanisms How Adipocytes Affect Bone in Aging Mice
    Fredric B Kraemer; Fiscal Year: 2010
    ....
  25. ApoA-I Helical Domains and Cardiovascular Aging
    JOHN BIELICKI; Fiscal Year: 2005
    ..These studies are relevant for devising novel strategies to combat cardiovascular aging. ..
  26. 2006 Lipoprotein Metabolism Gordon Conference
    MARY SORCI THOMAS; Fiscal Year: 2006
    ....
  27. VLDL and LDL Particle Types as CHD Risk Factors
    Frank Sacks; Fiscal Year: 2006
    ..abstract_text> ..
  28. Sphingosine-1-phosophate signaling in vasculogenesis
    KELLEY ARGRAVES; Fiscal Year: 2009
    ..Characterize the involvement of integrins in S1P-induced angioblast motility, and 3. Determine the significance S1P signaling to adult vasculogenesis mediated by circulating angioblasts. ..
  29. Dietary Macronutrients and Weight Loss
    Frank Sacks; Fiscal Year: 2008
    ..The results will be straightforwardly applicable to public health and clinical guidelines for obesity, and will increase our understanding of the biology of obesity and weight loss. ..
  30. SR-BI and SR-BII recycling and selective lipid uptake
    DENEYS VAN DER WESTHUYZEN; Fiscal Year: 2008
    ..Isoform-specific knock-in mice will be generated and the effects of each receptor on plasma lipoproteins, HDL metabolism and atherogenesis studied. [unreadable] [unreadable]..
  31. Estrogen, HDL, and coronary heart disease in women
    Stefania Lamon Fava; Fiscal Year: 2005
    ..The proposed analyses provide a unique opportunity to shed light on the physiological role of HDL subpopulations and HRT on CHD in women. ..
  32. REGULATION OF HORMONE SENSITIVE LIPASE
    FREDRIC KRAEMER; Fiscal Year: 2003
    ..The experiments outlined in this proposal will provide a comprehensive examination of the function and mechanisms of action of HSL in adipose tissue. ..
  33. PRESERVATION OF HDL FUNCTION DURING EARLY ATHEROGENESIS
    JOHN BIELICKI; Fiscal Year: 2002
    ..Moreover, the research will uncover novel mechanisms for preserving HDL/LCAT function that can be utilized therapeutically to fight the onset of cardiovascular disease. ..
  34. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    MOLLY CARR; Fiscal Year: 2004
    ..They will also elucidate the mechanisms that underlie the shifts in LDL size with oral and transdermal ERT. ..
  35. EFFECT OF DIETARY LIPIDS ON THE FUNCTION OF CHYLOMICRONS
    Byung Hong Chung; Fiscal Year: 2002
    ..abstract_text> ..
  36. CLASS B SCAVENGER RECEPTORS AND FOAM CELL FORMATION
    DENEYS VAN DER WESTHUYZEN; Fiscal Year: 2003
    ..The extent of atherosclerosis will be quantified by lesion size and cholesterol/cholesterol ester content. ..
  37. KINETICS OF HUMAN POSTPRANDIAL LIPOPROTEIN METABOLISM
    Frank Sacks; Fiscal Year: 2001
    ..These studies will increase our understanding of the metabolic pathways that are activated or suppressed postprandially, and could lead to treatments for reducing the development of atherosclerosis. ..
  38. Early Forms of Oxidized LDL, TLRs and Atherosclerosis
    Yury Miller; Fiscal Year: 2010
    ..Because the oxidized moieties in mmLDL are likely to be common components of oxidized membranes in general, these studies are likely to have generalized importance. ..
  39. HEMODYNAMIC REGULATION OF VASCULAR SMOOTH MUSCLE CELL
    EILEEN REDMOND; Fiscal Year: 2001
    ..These experiments should provide valuable information central to our understanding of the important role hemodynamic forces play in vascular biology,a nd thus further our knowledge of its role in the etiology of cardiovascular disease. ..
  40. EXERCISE--MUSCLE BLOOD FLOW, VASCULAR ADAPTATIONS
    RICHARD MCALLISTER; Fiscal Year: 2001
    ..This comprehensive research program, ranging from the skeletal muscle microcirculation to the intact animals will improve our understanding of the cardiovascular response to exercise in health and disease. ..
  41. LINKING RESOURCES FOR BROWN MEDICAL NUTRITION EDUCATION
    Charles Eaton; Fiscal Year: 2002
    ....
  42. ABCA1, ApoAI, and Lipid Efflux
    Jonathan Smith; Fiscal Year: 2008
    ..In addition, this study will include the identification of the apoAl oxidative modification by the enzyme myeloperoxidase that diminishes its lipid acceptor activity. ..
  43. COMPARATIVE GENOMIC ANALYSIS OF CARDIOVASCULAR GENE REGU
    Ronald Krauss; Fiscal Year: 2003
    ..6) The establishment of an educational program for cardiovascular researchers in the use of genomic databases and tools. ..
  44. Why is Cardiac Risk Increased in Rheumatiod Arthritis
    Daniel Solomon; Fiscal Year: 2002
    ..ability to control for known cardiovascular risk factors, the extensive medication information allowing for us to explore key hypotheses regarding corticosteroid exposure, and the attempt to simultaneously control for disease severity ..
  45. Translating the DPP into the Community: The YMCA model
    Ronald Ackermann; Fiscal Year: 2007
    ..In combination, these data will enable us to design and conduct a larger, future 3-year trial focusing on the effectiveness and sustainability of community DPP translation in multiple YMCA settings. ..
  46. The Role of Plasma Phospholipid Transfer Protein in Atherosclerosis
    Xian Cheng Jiang; Fiscal Year: 2010
    ....
  47. REACTIVE ALDEHYDES AND CARDIOVASCULAR AGING
    Jay Heinecke; Fiscal Year: 2002
    ..Finally, the investigators will determine whether macrophages possess a novel receptor for aldehyde-modified lipoproteins that might contribute to the deposition of cholesterol in the artery wall. ..
  48. Intergenerational Resemblances in Eating: the CSFII
    Sibylle Kranz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. Novel targets and agents to treat thrombotic disorders
    John Griffin; Fiscal Year: 2004
    ..abstract_text> ..
  50. New ECG Criteria for Posterior Myocardial Infarction
    Shu Fen Wung; Fiscal Year: 2004
    ..This study will aid in the detection and follow-up of patients with posterior myocardial infarction. ..
  51. Apolipoproteins and the complications of Type 1 diabetes
    Timothy Lyons; Fiscal Year: 2005
    ..The study brings together a unique population (DCCT/EDIC) with an important descriptor of lipoproteins never used in Type 1 diabetes, with the goal of preventing and treating complications ..
  52. Pain Medication Use & Risk Factors for Opioid Dependence
    Daniel Solomon; Fiscal Year: 2004
    ..Our goal is to use the results of the proposed research to inform a future intervention to improve opioid prescribing within this large pharmacy benefits program. ..
  53. The Epidemiology of Marine Fatty Acids and Preeclampsia
    Michelle Williams; Fiscal Year: 2006
    ....
  54. Pathways for the Inflammatory Damage of Biomolecules
    Jay Heinecke; Fiscal Year: 2006
    ..abstract_text> ..
  55. Treatment of Crohn's Disease with Growth Hormone
    Tamara Hannon; Fiscal Year: 2006
    ....
  56. Drugs targeting intact lipoprotein receptors
    BRUCE SACHAIS; Fiscal Year: 2004
    ..Specific Aim 2: Create and validate biosensor-based analysis of LDL-R lipoparticles. In this aim, we will use LDL-R lipoparticles on the optical biosensor platform with the goal of measuring ligand-binding kinetics. ..
  57. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    Robert Mahley; Fiscal Year: 2003
    ..Finally, funds are requested to equip a Behavioral Core Laboratory, which is essential for characterizing mouse models of human disease. ..
  59. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
    ..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
  60. MECHANISMS OF ACTIONS OF ALCOHOL AND OMEGA 3-FATTY ACIDS
    Raj Lakshman; Fiscal Year: 2004
    ....
  61. Insulin Resistance and Polycystic Ovary Syndrome
    Ann Brown; Fiscal Year: 2006
    ..Does exercise that reduces insulin resistance also decrease androgen levels? 3. Does exercise improve indicators of perceived body image, quality of life, stress and depression? ..
  62. Integrating the Metabolic and Genetic Faces of Obesity
    Gerald Reaven; Fiscal Year: 2008
    ..We believe that this work will add substantially to the current gap in knowledge regarding the link between obesity and insulin-resistance, and ultimately aid in the development of novel therapeutic targets. ..
  63. Estrogen and Mechanisms of Cardiomyocyte Protection
    Richard Karas; Fiscal Year: 2009
    ....
  64. Mechanistic study of CHD risk in subjects with high HDLC
    Marina Cuchel; Fiscal Year: 2008
    ....
  65. Lipoproteins, HIV, and Antiretroviral Therapy in SMART
    Daniel Duprez; Fiscal Year: 2008
    ..This proposal will produce additional information that will enhance their disease-free survival rate. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  66. Development of blood lipid biomarkers for Alzheimer's disease progression
    Michelle Mielke; Fiscal Year: 2008
    ..A major application would be as a surrogate or secondary outcome measure in clinical trials of emerging therapies for AD. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  67. INTERACTIONS OF LP(A) WITH VASCULAR EXTRACELLULAR MATRIX
    ANGELO SCANU; Fiscal Year: 2002
    ..Underlying these studies is the hypothesis, that the MMP-mediated changes in Lp(a)/apo(a) are favored by the inflammatory milieu of the human atheroma. ..
  68. Regulation of Vascular Inflammation
    Charles Lowenstein; Fiscal Year: 2007
    ..These studies will characterize novel molecular mechanisms by which radicals regulate vascular inflammation. [unreadable] [unreadable]..