ceramides

Summary

Summary: Members of the class of neutral glycosphingolipids. They are the basic units of SPHINGOLIPIDS. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in FABRY DISEASE.

Top Publications

  1. pmc Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2070-5. 2004
  2. ncbi Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    William L Holland
    Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 5:167-79. 2007
  3. pmc Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    William L Holland
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 121:1858-70. 2011
  4. pmc Many ceramides
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SouthCarolina 29425, USA
    J Biol Chem 286:27855-62. 2011
  5. pmc Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    William L Holland
    Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 17:55-63. 2011
  6. ncbi Ceramides in insulin resistance and lipotoxicity
    Scott A Summers
    Division of Endocrinology, Diabetes, and Metabolism, University of Utah School of Medicine, Building 585, Room 110, Salt Lake City, UT 84132, USA
    Prog Lipid Res 45:42-72. 2006
  7. ncbi Biologically active sphingolipids in cancer pathogenesis and treatment
    Besim Ogretmen
    Department of Biochemistry and Molecular Biology, and Hollings Cancer Center, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Cancer 4:604-16. 2004
  8. ncbi Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
    K Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    Diabetes 50:69-76. 2001
  9. ncbi Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
    Francesca Scarlatti
    INSERM U504, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    J Biol Chem 279:18384-91. 2004
  10. ncbi Ceramide synthases: roles in cell physiology and signaling
    Johnny Stiban
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Adv Exp Med Biol 688:60-71. 2010

Detail Information

Publications305 found, 100 shown here

  1. pmc Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
    Roy G Cutler
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2070-5. 2004
    ..metabolism during normal brain aging and in the brains of AD patients that result in accumulation of long-chain ceramides and cholesterol...
  2. ncbi Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    William L Holland
    Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 5:167-79. 2007
    ..Second, they identify enzymes required for ceramide synthesis as therapeutic targets for combating insulin resistance caused by nutrient excess or glucocorticoid therapy...
  3. pmc Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    William L Holland
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 121:1858-70. 2011
    ..These findings suggest that sphingolipids such as ceramide might be key components of the signaling networks that link lipid-induced inflammatory pathways to the antagonism of insulin action that contributes to diabetes...
  4. pmc Many ceramides
    Yusuf A Hannun
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SouthCarolina 29425, USA
    J Biol Chem 286:27855-62. 2011
    ..related molecules, subject to metabolism by >28 enzymes and with >200 structurally distinct mammalian ceramides distinguished by specific structural modifications...
  5. pmc Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    William L Holland
    Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 17:55-63. 2011
    ..Combined, our observations suggest a unifying mechanism of action for the beneficial systemic effects exerted by adiponectin, with sphingolipid metabolism as its core upstream signaling component...
  6. ncbi Ceramides in insulin resistance and lipotoxicity
    Scott A Summers
    Division of Endocrinology, Diabetes, and Metabolism, University of Utah School of Medicine, Building 585, Room 110, Salt Lake City, UT 84132, USA
    Prog Lipid Res 45:42-72. 2006
    ..In this review, I will evaluate the contribution of ceramides in the development of insulin resistance and the complications associated with metabolic diseases.
  7. ncbi Biologically active sphingolipids in cancer pathogenesis and treatment
    Besim Ogretmen
    Department of Biochemistry and Molecular Biology, and Hollings Cancer Center, 173 Ashley Avenue, Charleston, South Carolina 29425, USA
    Nat Rev Cancer 4:604-16. 2004
  8. ncbi Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
    K Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    Diabetes 50:69-76. 2001
    ....
  9. ncbi Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1
    Francesca Scarlatti
    INSERM U504, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    J Biol Chem 279:18384-91. 2004
    ..of autophagic vacuoles) in the human colon cancer HT-29 cells by increasing the endogenous pool of long chain ceramides as demonstrated by the use of the ceramide synthase inhibitor fumonisin B(1)...
  10. ncbi Ceramide synthases: roles in cell physiology and signaling
    Johnny Stiban
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Adv Exp Med Biol 688:60-71. 2010
    ..Finally, we discuss the putative roles of CerS and the ceramide derived from the CerS, in signaling pathways and in development of disease...
  11. ncbi Ceramide content is increased in skeletal muscle from obese insulin-resistant humans
    John M Adams
    Department of Physiology, The University of Texas Health Science Center at San Antonio, 78229 3900, USA
    Diabetes 53:25-31. 2004
    ..b>Ceramides, either generated via activation of sphingomyelinase or produced by de novo synthesis, induce insulin resistance ..
  12. pmc Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes 58:337-43. 2009
    ..b>Ceramides are a putative mediator of insulin resistance and lipotoxicity, and accumulation of ceramides within tissues in ..
  13. pmc Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair
    Christina Tam
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 189:1027-38. 2010
    ....
  14. ncbi Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
    Philipp A Lang
    Institute of Physiology University of Tübingen, 72076 Tubingen, Germany
    Nat Med 13:164-70. 2007
    ..Our data suggest a previously unidentified mechanism for liver cirrhosis and anemia in Wilson disease...
  15. ncbi Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    Roberto Lupi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:1437-42. 2002
    ..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated...
  16. ncbi A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    Jose Antonio Chavez
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins 80523 1870, USA
    J Biol Chem 278:10297-303. 2003
    ..By contrast, diacylglycerol proved dispensable for these FFA effects. Collectively these results identify ceramide as a necessary and sufficient intermediate linking saturated fats to the inhibition of insulin signaling...
  17. ncbi Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance
    C Lipina
    Division of Cell Signalling and Immunology, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK
    Diabetologia 54:1596-607. 2011
    ..By doing so, we outline potential therapeutic targets that may prove useful in the treatment of metabolic disorders...
  18. pmc Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches
    Jacqueline V Chapman
    John Wayne Cancer Institute at Saint John s Health Center, Department of Experimental Therapeutics, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Biochem Pharmacol 80:308-15. 2010
    Due to recent use of short-chain ceramides in preclinical studies, we characterized C6-ceramide metabolism in cancer cell lines and assessed metabolic junctures for enhancing efficacy...
  19. pmc An overview of sphingolipid metabolism: from synthesis to breakdown
    Christopher R Gault
    Department of Biochemistry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Adv Exp Med Biol 688:1-23. 2010
    ..With this thought in mind, this chapter will pay tribute to the complex sphingolipids, but focus on the regulation of simple sphingolipid metabolism...
  20. ncbi De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis
    Gregory Seumois
    Department of Physiology, University of Liege, Boulevard de Colonster, Bâtiment B42, Sart Tilman, B 4000, Liege, Belgium
    J Leukoc Biol 81:1477-86. 2007
    ..is preceded by a substantial increase in the intracellular levels of 16 and 24 carbon atom (C(16)- and C(24))-ceramides, which are lipid second messengers of apoptosis and stress signaling...
  21. pmc The sphingolipid salvage pathway in ceramide metabolism and signaling
    Kazuyuki Kitatani
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, South Carolina 29425, United States
    Cell Signal 20:1010-8. 2008
    ..This review focuses on the salvage pathway in ceramide metabolism, its regulation, its experimental analysis, and emerging biological functions...
  22. ncbi Regulation of ceramide channels by Bcl-2 family proteins
    Vidyaramanan Ganesan
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    FEBS Lett 584:2128-34. 2010
    ..The evolutionarily conserved regulation of ceramide channels by Bcl-2 family proteins, consistent with their role in apoptosis, lends credibility to the notion that ceramide channels constitute the protein release pathway...
  23. ncbi High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides
    Emanuel Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom
    J Proteome Res 7:4266-77. 2008
    ..Also, ceramides were identified to be significantly increased in white matter of both neuropsychiatric disorders as compared to ..
  24. pmc Use of high performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the analysis of ceramide-1-phosphate levels
    Dayanjan S Wijesinghe
    Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    J Lipid Res 51:641-51. 2010
    ..In conclusion, this study introduces a much improved and validated method for detection of C1P by mass spectrometry and demonstrates specific changes in the C1P subspecies profiles upon downregulation of CERK and CERT...
  25. ncbi Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
    ..Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation...
  26. ncbi Sphingosine kinase, sphingosine-1-phosphate, and apoptosis
    Michael Maceyka
    Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, 1101 E Marshall St, Richmond, VA 23298 0614, USA
    Biochim Biophys Acta 1585:193-201. 2002
    ..Med. 6 (2000) 1109]. Here we review the growing literature on the regulation of SphK and the role of SphK and its product, S1P, in apoptosis...
  27. ncbi Ceramide in stress response
    Mariana N Nikolova-Karakashian
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA
    Adv Exp Med Biol 688:86-108. 2010
    ....
  28. pmc Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
    Guang Yang
    Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, USA
    Am J Physiol Endocrinol Metab 297:E211-24. 2009
    ..diet-induced obese (DIO) mice with myriocin, an inhibitor of de novo ceramide synthesis, decreased circulating ceramides. Decreased ceramide was associated with reduced weight, enhanced metabolism and energy expenditure, decreased ..
  29. pmc Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
    Francesca Amati
    Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:2588-97. 2011
    ..chronically exercise-trained muscle would be characterized by lower skeletal muscle diacylglycerols (DAGs) and ceramides despite higher IMTGs and would account for its higher insulin sensitivity...
  30. ncbi Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
    P Santana
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center New York, New York 10021, USA
    Cell 86:189-99. 1996
    ..These genetic models provide definitive evidence for the involvement of acid sphingomyelinase in one form of stress-induced apoptosis...
  31. pmc Ceramides as modulators of cellular and whole-body metabolism
    Benjamin T Bikman
    Duke National University of Singapore Graduate Medical School, Singapore
    J Clin Invest 121:4222-30. 2011
    ..induce sphingolipid synthesis, leading to the accumulation of ceramides and ceramide metabolites...
  32. ncbi When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
    Yael Pewzner-Jung
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 281:25001-5. 2006
  33. ncbi Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer
    M Selzner
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 61:1233-40. 2001
    ..These studies also suggest that the ceramide content in cancer cells might be involved in the pathogenesis of tumor growth in vitro and in vivo...
  34. ncbi Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
    Elad L Laviad
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 283:5677-84. 2008
    ..Recent studies have implied a previously unappreciated role for the ceramide N-acyl chain length, inasmuch as ceramides containing specific fatty acids appear to play defined roles in cell physiology...
  35. pmc Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance
    Suriyan Ponnusamy
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
    Future Oncol 6:1603-24. 2010
    ..Interestingly, recent studies suggest de novo-generated ceramides may have distinct and opposing roles in the promotion/suppression of tumors, and that these activities are based ..
  36. ncbi Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia
    Norman J Haughey
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Ann Neurol 55:257-67. 2004
    ..These results suggest that HIV-1 infection may promote a lipid imbalance in neural cells, resulting in an overproduction of ceramide and consequent cellular dysfunction and death...
  37. ncbi Sphingomyelin and ceramide as regulators of development and lifespan
    R G Cutler
    Laboratory of Neurosciences, 4F02, National Institute on Aging, Gerontology Research Center, 5600, Nathan Shock Drive, Baltimore, MD 21224, USA
    Mech Ageing Dev 122:895-908. 2001
    ..The emerging data suggest the possibility that dietary and pharmacological manipulations of SM metabolism might prove effective in extending lifespan and treating various age-related diseases...
  38. ncbi CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides
    T Kawano
    CREST Core Research for Evolutional Science and Technology Project, Japan Science and Technology Corporation JST, 1 8 1 Inohana, Chuo, Chiba 260, Japan
    Science 278:1626-9. 1997
    ..Thus, this lymphocyte shares distinct recognition systems with either T or NK cells...
  39. ncbi Effect of the structure of natural sterols and sphingolipids on the formation of ordered sphingolipid/sterol domains (rafts). Comparison of cholesterol to plant, fungal, and disease-associated sterols and comparison of sphingomyelin, cerebrosides, and cer
    X Xu
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook, Stony Brook, New York 11794-5215, USA
    J Biol Chem 276:33540-6. 2001
    ..The molecular basis for, and the implications of, the effects of different sterols and sphingolipids (especially ceramide) on the behavior and biological function of rafts are discussed...
  40. ncbi Acid and neutral sphingomyelinases: roles and mechanisms of regulation
    Norma Marchesini
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, 29425, USA
    Biochem Cell Biol 82:27-44. 2004
    ....
  41. ncbi Raft ceramide in molecular medicine
    Erich Gulbins
    Department of Molecular Biology, University of Duisburg Essen, Hufelandstrasse 55, Essen 45122, Germany
    Oncogene 22:7070-7. 2003
    ....
  42. ncbi Ceramide in the eukaryotic stress response
    Y A Hannun
    Dept of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29495, USA
    Trends Cell Biol 10:73-80. 2000
    ..They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence...
  43. ncbi Ceramide levels are inversely associated with malignant progression of human glial tumors
    Laura Riboni
    Department of Medical Chemistry and Biochemistry, Study Center for the Functional Biochemistry of Brain Lipids, University of Milan, LITA Segrate, Segrate, Milan, Italy
    Glia 39:105-13. 2002
    ..The low ceramide levels in high-grade tumors may provide an advantage for their rapid growth and apoptotic resistant features. This study appears to support the rationale for the potential benefits of a ceramide-based chemotherapy...
  44. ncbi Inhibition of sphingomyelinase activity helps to prevent neuron death caused by ischemic stress
    Shinji Soeda
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Neurochem Int 45:619-26. 2004
    ....
  45. ncbi Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells
    Sandrine Lacour
    Institut National de la Sante et de la Recherche Médicale U517, Dijon, France
    Cancer Res 64:3593-8. 2004
    ..Such redistribution contributes to cell death and sensitizes tumor cells to CD95-mediated apoptosis...
  46. pmc Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance
    James Boon
    Biology of Lipid Metabolism Laboratory, Department of Physiology, Monash University, Clayton, Victoria, Australia
    Diabetes 62:401-10. 2013
    ..These newly identified roles of LDL-ceramide suggest that strategies aimed at reducing hepatic ceramide production or reducing ceramide packaging into lipoproteins may improve skeletal muscle insulin action...
  47. ncbi Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis
    Xianlin Han
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 82:809-18. 2002
    ..examination of galactocerebroside sulfotransferase activities in post-mortem brain tissues; (iii) the content of ceramides (a class of potential degradation products of sulfatides) was elevated more than three-fold in white matter and ..
  48. pmc Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins
    Leah J Siskind
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    J Biol Chem 277:26796-803. 2002
    b>Ceramides are known to play a major regulatory role in apoptosis by inducing cytochrome c release from mitochondria...
  49. pmc Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network
    Can E Senkal
    Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 286:42446-58. 2011
    ..Recent data suggest that ceramide synthase1-6 (CerS1-6)-generated ceramides, containing different fatty acid chain lengths, might exhibit distinct and opposing functions, such as apoptosis ..
  50. ncbi Ceramide glycosylation potentiates cellular multidrug resistance
    Y Y Liu
    John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA
    FASEB J 15:719-30. 2001
    ..This study reveals that GCS is a novel mechanism of multidrug resistance and positions GCS antisense as an innovative force to overcome multidrug resistance in cancer chemotherapy...
  51. pmc Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes
    Susumu Mitsutake
    Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001 0021, Japan
    J Biol Chem 286:28544-55. 2011
    ..Our findings demonstrate the novel and dynamic regulation of lipid microdomains via conformational changes in lipids on the plasma membrane by SMS2, which is responsible for obesity and type 2 diabetes...
  52. pmc Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II
    Michelle M Mielke
    Division of Epidemiology, College of Medicine, Mayo Clinic, Rochester, MN, USA
    Neurology 79:633-41. 2012
    Previous studies have shown that high serum ceramides are associated with memory impairment and hippocampal volume loss, but have not examined dementia as an outcome...
  53. ncbi Chain length-specific properties of ceramides
    Sabine Grosch
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe Universitat Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Prog Lipid Res 51:50-62. 2012
    b>Ceramides are a class of sphingolipids that are abundant in cell membranes. They are important structural components of the membrane but can also act as second messengers in various signaling pathways...
  54. pmc Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
    S D Long
    Department of Biochemistry, School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Biochem J 319:179-84. 1996
    ..These data establish that ceramide-initiated signal transduction pathways exist within the adipocyte, and provide a potential mechanism for control of GLUT4 gene expression...
  55. ncbi Ceramide formation as a target in beta-cell survival and function
    Florian Lang
    University of Tubingen, Institute of Physiology, Germany
    Expert Opin Ther Targets 15:1061-71. 2011
    ..Ceramide may be synthesized de novo or generated by sphingomyelinase-dependent hydrolysis of sphingomyelin...
  56. pmc Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation
    Hyunmi Lee
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e19783. 2011
    ....
  57. ncbi A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome
    Scott A Summers
    Division of Endocrinology, Metabolism and Diabetes, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Diabetes 54:591-602. 2005
    ..Interestingly, numerous studies identify ceramides and other sphingolipids as potential contributors to these sequelae...
  58. ncbi Ceramide-enriched membrane domains
    Claudia R Bollinger
    Department of Molecular Biology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Biochim Biophys Acta 1746:284-94. 2005
    ....
  59. pmc Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology
    Catherine Pavoine
    INSERM, Unite U955, Creteil F 94010, France
    Cardiovasc Res 82:175-83. 2009
    ..Neutral SMase inhibitors could be tools for the treatment of atherosclerosis, heart failure, and age-related decline in vasomotion. However, the design of bioavailable and more specific SMase-type inhibitors remains a challenge...
  60. ncbi Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk
    Fahumiya Samad
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    Diabetes 55:2579-87. 2006
    ....
  61. pmc Ceramide: second messenger or modulator of membrane structure and dynamics?
    Wim J van Blitterswijk
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem J 369:199-211. 2003
    ..Given the limited capacity for spontaneous intracellular diffusion or membrane flip-flop of natural ceramide species, the topology and membrane sidedness of ceramide generation are crucial determinants of its impact on cell biology...
  62. ncbi Ceramide in apoptosis: an overview and current perspectives
    Benjamin J Pettus
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
    Biochim Biophys Acta 1585:114-25. 2002
    ....
  63. pmc Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas
    Silke Imgrund
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, Romerstrasse 164, 53117 Bonn, Germany
    J Biol Chem 284:33549-60. 2009
    ..Our results indicate that CERS2 activity supports different biological functions: maintenance of myelin, stabilization of the cerebellar as well as renal histological architecture, and protection against hepatocarcinomas...
  64. ncbi Ceramide synthesis and metabolism as a target for cancer therapy
    C Patrick Reynolds
    Division of Hematology Oncology MS 57, Children s Hospital of Los Angeles, The University of Southern California Keck School of Medicine, 4650 Sunset Blvd, Los Angeles, CA 90054 0700, USA
    Cancer Lett 206:169-80. 2004
    Sphingolipids, which include ceramides and sphingosine, are essential structural components of cell membranes that also have messenger functions that regulate the proliferation, survival, and death of cells...
  65. pmc Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans
    Xinzhu Deng
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center MSKCC, New York, NY 10021, USA
    Science 322:110-5. 2008
    ....
  66. ncbi Radiation and ceramide-induced apoptosis
    Richard Kolesnick
    Laboratory of Signal Transduction, Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Oncogene 22:5897-906. 2003
    ..An improved understanding of this signaling system may offer new opportunities for the modulation of radiation effects in the treatment of cancer...
  67. ncbi Key role for ceramides in mediating insulin resistance in human muscle cells
    Laura Pickersgill
    Institute of Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    J Biol Chem 282:12583-9. 2007
    ..Furthermore, the triacylglycerol derived from oleate was able to exert a protective role in sequestering palmitate, thus preventing its conversion to ceramide...
  68. ncbi Ceramide channels and their role in mitochondria-mediated apoptosis
    Marco Colombini
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Biochim Biophys Acta 1797:1239-44. 2010
    ..Ceramide channels are good candidates for the protein release pathway that initiates the execution phase of apoptosis...
  69. ncbi Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide
    Eric Hajduch
    Centre de Recherche des Cordeliers, Paris F 75006, France
    Biochem J 410:369-79. 2008
    ..We conclude that the recruitment and retention of PKB within CEM contribute significantly to ceramide-induced inhibition of PKB-directed signalling...
  70. ncbi Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease
    V D F de Mello
    Department of Clinical Nutrition Food and Health Research Centre, School of Public Health and Clinical Nutrition, University of Kuopio, P O Box 1627, Kuopio, Finland
    Diabetologia 52:2612-5. 2009
    b>Ceramides and IL-6 have a role in immune-inflammatory responses and cardiovascular diseases, and are suggested to be involved in insulin and glucose metabolism...
  71. pmc Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
    Darren J Powell
    Division of Molecular Physiology, Faculty of Life Sciences, MSI WTB complex, University of Dundee, Dundee, DD1 5EH, Scotland
    Biochem J 382:619-29. 2004
    ..These findings indicate that intracellular ceramide synthesis and PKCzeta activation are important aspects of the mechanism by which palmitate desensitizes L6 muscle cells to insulin...
  72. pmc Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
    Tae Sik Park
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Lipid Res 49:2101-12. 2008
    ..Our results suggest a critical role for ceramide accumulation in the pathogenesis of lipotoxic cardiomyopathy...
  73. ncbi Ceramide mediates caspase-independent programmed cell death
    Lutz Thon
    Institut fur Immunologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Kiel, Germany
    FASEB J 19:1945-56. 2005
    ..Moreover, clonogenic survival of tumor cells is clearly reduced by induction of the ceramide death pathway, promising additional options for the development of novel tumor therapies...
  74. ncbi Co-administration of perifosine with paclitaxel synergistically induces apoptosis in ovarian cancer cells: more than just AKT inhibition
    Hui Sun
    Central Lab, Jining First People s Hospital, 6 Jiankang Road, Jining City, Shandong Province 272111, PR China
    Cancer Lett 310:118-28. 2011
    ..These signaling events together caused a marked increase of cancer cell apoptosis. Combining paclitaxel with perifosine may represent a novel anti-ovarian cancer strategy...
  75. pmc Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways
    Can E Senkal
    Hollings Cancer Center, 86 Jonathan Lucas Street, Charleston, SC 29425, USA
    FASEB J 24:296-308. 2010
    Emerging results suggest that ceramides with different fatty acid chain lengths might play distinct functions in the regulation of tumor growth and therapy...
  76. pmc The therapeutic potential of modulating the ceramide/sphingomyelin pathway
    Richard Kolesnick
    Laboratory of Signal Transduction, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    J Clin Invest 110:3-8. 2002
  77. ncbi Ceramide triggers metacaspase-independent mitochondrial cell death in yeast
    Didac Carmona-Gutierrez
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Cell Cycle 10:3973-8. 2011
    ..Altogether, our results point to a pivotal role of mitochondria in ceramide-induced yeast cell death...
  78. ncbi Ceramide-rich platforms in transmembrane signaling
    Branka Stancevic
    Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    FEBS Lett 584:1728-40. 2010
    ..The biomedical significance of CRPs makes these structures an attractive therapeutic target...
  79. pmc A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways
    Yael Pewzner-Jung
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 285:10902-10. 2010
    ..is surprisingly complex and is orchestrated by six mammalian ceramide synthases, each of which produces ceramides with restricted acyl chain lengths...
  80. ncbi Ceramide and activated Bax act synergistically to permeabilize the mitochondrial outer membrane
    Vidyaramanan Ganesan
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Apoptosis 15:553-62. 2010
    ..These and previous findings that anti-apoptotic proteins disassemble ceramide channels suggest that ceramide channels, regulated by Bcl-2-family proteins, may be responsible for the MOMP during apoptosis...
  81. pmc C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p
    I Guillas
    Institute of Biochemistry, University of Fribourg, CH 1700 Fribourg, Switzerland
    EMBO J 20:2655-65. 2001
    ..As a consequence, in intact cells, the normal ceramides and inositolphosphorylceramides are drastically reduced...
  82. ncbi Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis
    Moira Sauane
    Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, Virginia
    J Cell Physiol 222:546-55. 2010
    ..Infection with Ad.mda-7 induced a marked increase in various ceramides (C16, C24, C24:1) selectively in prostate cancer cells...
  83. pmc Blood sphingolipidomics in healthy humans: impact of sample collection methodology
    Samar M Hammad
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Lipid Res 51:3074-87. 2010
    ..Per particle, VLDL contained the highest levels of SM, Cer, and S1P. HPLC-MS/MS should provide a tool for clinical testing of circulating bioactive sphingolipids in human blood...
  84. pmc Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling
    Archana Mukhopadhyay
    Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
    FASEB J 23:751-63. 2009
    ....
  85. pmc Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
    Cungui Mao
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Biochim Biophys Acta 1781:424-34. 2008
    Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is phosphorylated to form sphingosine-1-phosphate (S1P)...
  86. ncbi Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice
    Mohammad Reza Hojjati
    Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, New York 11203, USA
    J Biol Chem 280:10284-9. 2005
    ..Thus, inhibition of SPT activity could be an alternative treatment for atherosclerosis...
  87. pmc The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
    Xiaoyong Lei
    Department of Medicine, Mass Spectrometry Resource, and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 46:10170-85. 2007
    ..These findings suggested that iPLA2beta and ceramides participate in ER stress-induced INS-1 cell apoptosis...
  88. ncbi Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
    Clarissa von Haefen
    Department of Hematology, Oncology and Tumor Immunology, University Medical Center Charite, Humboldt University of Berlin, 13125, Germany
    Oncogene 21:4009-19. 2002
    ..Thus, we conclude that Bax is a key activator of ceramide-mediated death pathways...
  89. ncbi Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease
    K Horinouchi
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Genet 10:288-93. 1995
    ..Thus, the ASM deficient mice should be of great value for studying the pathogenesis and treatment of NPD, and for investigations into the role of ASM in signal transduction and apoptosis...
  90. pmc Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis
    Xiaoyong Lei
    Department of Medicine, Mass Spectrometry Resource and Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:34819-32. 2008
    ..phospholipase A(2) (iPLA(2)beta)-mediated ceramide generation, but the mechanism by which iPLA(2)beta and ceramides contribute to apoptosis is not well understood...
  91. pmc Sphingosine 1-phosphate signalling in mammalian cells
    S Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK
    Biochem J 349:385-402. 2000
    ..This article describes where the research field is in relation to achieving this aim...
  92. ncbi CD95 signaling via ceramide-rich membrane rafts
    H Grassme
    Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 276:20589-96. 2001
    ..The data suggest CD95-mediated clustering by ceramide is prerequisite for signaling and death...
  93. ncbi Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin
    Alistair Boath
    Novartis Institutes for BioMedical Research, Vienna, Brunnerstrasse 59, Wien, Austria
    J Biol Chem 283:8517-26. 2008
    ..After these experiments we used an overexpression system, BMDM from Cerk(-/-) mice, and short-chain fluorescent ceramides to trace CerK-dependent formation of C1P...
  94. ncbi Biological aspects of ceramide-enriched membrane domains
    Heike Grassme
    Institute of Molecular Biology, University of Duisburg Essen, 45122 Essen, Germany
    Prog Lipid Res 46:161-70. 2007
    ..In addition, ceramide directly interacts with and stimulates intracellular enzymes that may act together with signals initiated in ceramide-enriched membrane domains to transmit signals into a cell...
  95. ncbi Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway
    Chia Ling Chen
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Blood 111:4365-74. 2008
    ....
  96. ncbi Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
    Johannes M Aerts
    Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Diabetes 56:1341-9. 2007
    ....
  97. ncbi Bax and Bcl-xL exert their regulation on different sites of the ceramide channel
    Meenu N Perera
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Biochem J 445:81-91. 2012
    ..The present study also revealed that Bcl-xL has an optimal interaction with long-chain ceramides that are elevated early in apoptosis, whereas short-chain ceramides are not well regulated...
  98. ncbi Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation
    Yusuf Baran
    Department of Molecular Biology and Genetics, Izmir Institute of Technology, Faculty of Science, Gulbahce Campus, 35430, Urla, Izmir, Turkey
    J Cancer Res Clin Oncol 137:1535-44. 2011
    ..2 and K562/IMA-1 human CML cells, which exhibit about 2.3- and 19-fold imatinib resistance, respectively...
  99. ncbi Lipoapoptosis: its mechanism and its diseases
    Roger H Unger
    Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8854, USA
    Biochim Biophys Acta 1585:202-12. 2002
    ....
  100. ncbi Ceramide metabolism is affected by obesity and diabetes in human adipose tissue
    A U Błachnio-Zabielska
    Department of Physiology, Medical University of Bialystok, Białystok, Poland
    J Cell Physiol 227:550-7. 2012
    ..67, P < 0.001). We have found that both obesity and diabetes affected pathways of sphingolipid metabolism in the adipose tissue...
  101. ncbi Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic beta-cells
    Jun Guo
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China
    Mol Cell Biochem 338:283-90. 2010
    ....

Research Grants62

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..accumulation of intramyocellular lipid (IMCL) and metabolites of LCFAs such as diacylglycerol, LCFA-CoAs, and ceramides. These latter compounds activate various serine kinases, such as PKC or IKK2 (in association with activation of ..
  3. Regulation/Role of AcylCer in Normal Epidermis and Atopic Dermatitis
    Peter M Elias; Fiscal Year: 2013
    ..A family of 10 ceramides (Cer) dominates in these membranes, accounting for about H50% of SC lipid, and therefore H5% of the total weight ..
  4. Gender Effects on Remodeling of Lipid and Sarcomere Dynamics in Hypertrophy
    E Douglas Lewandowski; Fiscal Year: 2013
    ..of lipid accumulation and b) sarcomere activity through phosphorylation effects of LCFA-derived intermediates, ceramides and sphingosine, on myofilament sensitivity in MHC-PPAR[unreadable] hearts...
  5. Signaling Sphingolipids in COPD
    Irina Petrache; Fiscal Year: 2009
    ..We have recently identified a novel role for ceramides in the lung as a central mediator of alveolar cell apoptosis and emphysema...
  6. Longitudinal study of membrane lipids: pre-clinical Alzheimer's biomarkers
    Michelle M Mielke; Fiscal Year: 2010
    ..Animal and human laboratory studies suggest associations between ceramides, sphingomyelins, 24S-hydroxycholesterol (24S-OHC), or F2a-Isoprostanes and neurodegeneration...
  7. The pathogenesis of insulin resistance in alcoholic liver disease
    Rotonya M Carr; Fiscal Year: 2013
    ..The application investigates the role of ceramides in insulin resistance in early alcoholic liver disease (ALD) and will be carried out in the laboratory of Dr...
  8. Protective Role of Intracellular S1P in Lung Injury
    Viswanathan Natarajan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sphingolipid metabolites such as ceramides and sphingoid bases are important modulators of cell survival, proliferation, angiogenesis, migration, and vascular integrity...
  9. Cardiac Lipotoxicity and Ceramide Metabolism in Heart Failure
    P Christian Schulze; Fiscal Year: 2013
    ..Further, preliminary animal studies revealed accumulation of long-chain ceramides in the failing myocardium...
  10. Adipose Triglyceride Lipase (ATGL) in Lipotoxicity and The Metabolic Syndrome
    Erin E Kershaw; Fiscal Year: 2013
    ..Emerging evidence suggests that non-TG lipid metabolites (i.e. diacylglycerols, ceramides, fatty-acyl CoAs, etc...
  11. DIETARY PREVENTION OF CARDIAC MITOCHONDRIAL AGING
    Tory M Hagen; Fiscal Year: 2011
    ..levels of oxidative stress, lower rates of ?3-oxidation, and have elevated levels of free fatty acids (FFA) and ceramides. The consequences of this IFM dyslipidemia are unknown but likely dire for the heart;other conditions exhibiting ..
  12. Using Molecular Modeling to Determine Structure and Organization in Skin Lipids
    Clare McCabe; Fiscal Year: 2012
    ..into ordered gel or crystalline phases can be ascribed to its unique composition;the SC is composed of mostly ceramides, free fatty acids and cholesterol, and, in contrast with most biological membranes, no phospholipids are present...
  13. Novel L-threo-sphinganines for ceramides-based cancer therapy
    Barry J Maurer; Fiscal Year: 2012
    ..b>Ceramides are sphingolipids with pro- death signaling properties...
  14. Role of Mixed Lineage Kinase 3/SPRK in Stress Signaling
    AJAY NMN RANA; Fiscal Year: 2010
    ..In addition, our more recent studies (both published and unpublished) indicate that (i) ceramides can directly associate, and activate MLK3, (ii) MLK3 mediates TNF-a and ceramide-induced JNK activation, (iii) ..
  15. Unsaturated glycoceramide as novel platform for mucosal vaccine and drug delivery
    Wayne Lencer; Fiscal Year: 2011
    ..When applied apically, GM1-ceramides containing "short" C12:0 or "kinked chain" unsaturated C16:1 fatty acids (GM1short/unsat) enter the common/..
  16. Ceramide-induced lung destruction in emphysema
    Irina Petrache; Fiscal Year: 2013
    ..We hypothesize that CS-induced ceramides trigger alveolar cell death, impair proper removal of apoptotic bodies, and disrupt cell repair due to ..
  17. Oxidative Capacity, Lipid Partitioning and Insulin Resistance in Skeletal Muscle
    John J Dube; Fiscal Year: 2011
    ..aerobic exercise alters skeletal muscle lipid partitioning (increased triglycerides but lower diacylglycerol and ceramides) and these changes may be related to perturbations in lipid droplet proteins and enhanced mitochondrial content ..
  18. The Role of Bioactive Lipids in Inflammation and Cancer
    RAYMOND NELSON DUBOIS; Fiscal Year: 2013
    ..Bioactive lipids such as eicosanoids, endocannabinoids, sphingolipids, and ceramides can initiate complex signaling networks that affect carcinogenesis...
  19. Synthesis and Screening of Bioactive Glycolipids
    Jacquelyn Gervay-Hague; Fiscal Year: 2012
    ..The specific aims include: 1.) Large scale syntheses of beta-galactosyl, glucosyl and lactosyl ceramides using transient protecting groups 2.) Syntheses of Gb3, GM3, GD3, GM1 using a novel sialylation method 3...
  20. Inflammasomes and the mechanism of thymic demise in aging
    Vishwa Deep Dixit; Fiscal Year: 2013
    ..We identified that ceramides (lipids with sphingosine linked to a fatty acid) which increase in aging thymus, trigger the activation of Nlrp3 ..
  21. Linking Lipoxygenases with Essential Fatty Acids and Epidermal Barrier Formation
    Alan R Brash; Fiscal Year: 2013
    ..and eLOX3 activity in the epidermis in vivo using animal models, (2) To assess the efficacy of LOX products and ceramides in rescuing the phenotype in murine LOX-/- models, (3) To characterize 12R-LOX and eLOX3 activity in human ..
  22. Harnessing NKT Cell Activation by Glycolipids
    Amy R Howell; Fiscal Year: 2010
    ..For the last five years our lab has designed and synthesized glycosyl ceramides that vary in the ceramide and sugar epitopes in order to probe the role of both regions...
  23. Ceramide Mediated Oxidative Stress in Muscle Loss with Aging and Disuse
    PAUL MARTIN COEN; Fiscal Year: 2013
    ..The proposed studies will provide, for the first time, novel translational evidence i both animals and humans that intramyocellular ceramides contribute to mitochondrial ROS production, sarcopenia and loss of physical function.
  24. ACRP, A PROTEIN SECRETED FROM ADIPOSE TISSUE
    Philipp E Scherer; Fiscal Year: 2013
    ..The basis for these observations is a reduction of local ceramides and/or an increase in the local sphingosine-1-P levels due to activation of the adiponectin receptors by ..
  25. Metabolic profiles of COPD phenotypes
    RUSSELL PAUL BOWLER; Fiscal Year: 2013
    ..The identification of spingolipids such as ceramides can serve as a paradigm for metabolome studies of COPD...
  26. Lipid Biomarkers for Diabetic Heart Disease
    Jean E Schaffer; Fiscal Year: 2013
    ..this problem by using sensitive mass spectrometry-based metabolomics to identify two plasma very long-chain ceramides, Cer(22:0) and Cer(24:0), that are highly correlated with asymptomatic systolic dysfunction in obese and type 2 ..
  27. Chemoprevention via modulation of autophagy by sphingolipids
    ALFRED HARRISON MERRILL; Fiscal Year: 2010
    ..The mechanism involves the induction of autophagy by ceramides (Cer), dihydroceramides (DHCer), and sphingosine 1-phosphate (S1P), with the latter being a critical determinant ..
  28. Role and Regulation of Ceramide Synthases in Apoptosis
    Lina M Obeid; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ceramides form the backbone of all sphingolipids, and they have emerged as important regulators/mediators of cellular stress responses...
  29. Neutral Ceramidase in Colon Cancer
    Yusuf Awni Hannun; Fiscal Year: 2013
    ..key, yet poorly studied, enzyme in regulating the interconversion of important bioactive molecules that include ceramides with an overall anti- tumor properties and sphingosine 1-phosphate with tumor-promoting properties...
  30. TOR Complex 2 and sphingolipid biosynthesis.
    Ted Powers; Fiscal Year: 2012
    ..affects dramatically the earliest steps of the sphingolipid pathway, in particular the de novo formation of ceramides, in budding yeast...
  31. Characterization of mammalian ceramide synthases
    ALFRED HARRISON MERRILL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ceramides (Cer) are comprised of a sphingoid base and amide-linked fatty acid, and are the backbones of complex sphingolipids as well as modulators of vital cellular processes...
  32. Anti-GM1b IgM for Detection of Localized Prostate Cancer
    Mepur Ravindranath; Fiscal Year: 2005
    The discovery that tumor cells escape ceramide-mediated apoptosis by glycosylating ceramides and storing them as gangliosides (lactosylceramides with sialic acids) suggests that gangliosides (Ggs) may be valuable targets for diagnostic ..
  33. BIOSYNTHESIS OF HUMAN PLATELET GLYCOSPHINGOLIPIDS
    CHENG TEH WANG; Fiscal Year: 1980
    ..We have shown that the sphingosine composition of human platelet ceramides and glycosphingolipids is different in that the former contain dihydrosphingosine, the latter contains ..
  34. Role of Lipolytic Enzymes in Intestinal Lipid Transport
    David Hui; Fiscal Year: 2009
    ..lipase (CEL) influences chylomicron production, possibly by a mechanism related to its ability to hydrolyze ceramides in the intestinal tract...
  35. GLYCOSPHINGOLIPIDS AND GM1-CHOLERA TOXIN INTERACTIONS
    G Shipley; Fiscal Year: 2000
    ..The Shipley group's successful de novo synthesis of ceramides and cerebrosides will be extended to globosides and gangliosides. Dr...
  36. REGULATION OF ENZYME OF LIPID METABOLISM
    Robert Bell; Fiscal Year: 1990
    ..Exogenously added sphingomyelinase and low levels of cell permeable ceramides potentiated HL60 cell differentiation at subthreshold levels of D3; at higher levels ,the cell permeable ..
  37. Biological Targets from Oxetane Templates
    Amy Howell; Fiscal Year: 2007
    ..proposal is the exploitation of methodology we have developed to prepare a rationally designed set of glycosyl ceramides that vary in both the ceramide and sugar epitopes in order to probe the role of both the lipid and the ..
  38. NEW METHODS FOR QUANTITATIVE GLYCOSPHINGOLIPIDOMICS
    STEVEN LEVERY; Fiscal Year: 2005
    Glycosphingolipids (GSLs: 1-O-glycosides of the N-acyl-sphingosines, or ceramides) are a structurally and functionally diverse class of biological compounds distributed among all eukaryotes and some bacteria...
  39. STRUCTURE/FUNCTION OF POLAR LIPIDS IN HUMAN SKIN
    DONALD DOWNING; Fiscal Year: 2000
    ..The third specific aim is to determine how ceramides of the long-chain omega-hydroxyacids control the arrangement of the intercellular lamellae in the stratum ..
  40. STUDIES OF NATURAL PRODUCTS BY CHIROPTICAL METHODS
    Koji Nakanishi; Fiscal Year: 2004
    ..will be applied on a sub- microgram scale for direct configurational assignment of synthetic and endogenous ceramides and phytosphingosines...
  41. NATURALLY OCCURING SHPINGOLIPIDS AND SPINGOLIPID ANALOGS
    ALFRED MERRILL; Fiscal Year: 2004
    ..Based on the mechanisms of action of ceramides and sphingo bases (and structure- function relationships for the metabolism of these compounds), synthetic ..
  42. PPARs and LXR Regulate Epidermal Differentiation
    Kenneth Feingold; Fiscal Year: 2006
    ..protective structures, keratinocytes must synthesize extensive quantities of cholesterol, fatty acids, and ceramides, delivered in an approximately equimolar ratio to the SC, simultaneous with formation of corneocytes, enriched ..
  43. Novel Ceramide-based Chemotherapy for Acute Leukemia
    Barry Maurer; Fiscal Year: 2007
    ..Determine if L-threo-dihydroceramides or L-threo-ceramides reproduce the effects of safingol. AIM 3...
  44. CHARACTERIZATION OF PNEUMOCYSTIS CARINII LIPIDS
    EDNA KANESHIRO; Fiscal Year: 2000
    ..in detail, to examine their biosynthesis, and to determine whether the organism releases long-chain bases, ceramides and/or fumonisns or fumonism-like sphingoid bases...
  45. LC/Q Mass Spectrometry for Lipid Analysis
    Yusuf Hannun; Fiscal Year: 2002
    ..4. Foster and further develop ongoing interdisciplinary research Among the various users. ..
  46. SPHINGOMYELIN TURNOVER AND CELLULAR REGULATION
    Yusuf Hannun; Fiscal Year: 2006
    ..These pathways are of direct significance to the biology of stress responses and specifically to cancer therapeutics. ..
  47. SCIEX 4000 QTRAP Mass Spectrometer
    Yusuf Hannun; Fiscal Year: 2008
    ..Strong institutional commitment ensures long term operation and maintenance of the requested instrument and overall facility. [unreadable] [unreadable] [unreadable]..
  48. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  49. Epidermal Mechanisms Opposing Ceramide-Induced Apoptosis
    Yoshikazu Uchida; Fiscal Year: 2009
    ....
  50. Regulation of neuronal stem cell death
    Erhard Bieberich; Fiscal Year: 2006
    ..In conclusion, this study will identify mechanisms for regulation of apoptosis by ceramide that are critical for normal brain development and/or the etiology of subsequent, pathological disorders in adulthood. ..
  51. Sphingolipids in Ethanol-Induced Neuronal Apoptosis
    Mariko Saito; Fiscal Year: 2010
    ..These studies will reveal the functions of sphingolipids in ethanol-induced apoptosis in the developing brain, and will offer bases for future therapeutic strategies for FASD. ..
  52. Blood-based lipid biomarkers reflective of Alzheimer-associated neurodegeneration
    Michelle Mielke; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  54. Alkaline Ceramidase and Sphingolipid Signaling
    Cungui Mao; Fiscal Year: 2008
    ..that the PI recently cloned, has an important role in regulating the levels of S1P by controlling hydrolysis of ceramides, a rate-limiting step for the formation of S1P, and importantly, haCER2 is capable of regulating S1P-mediated ..
  55. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  56. HIV Associated CNS Dysfunction with Aging
    Norman Haughey; Fiscal Year: 2007
    ..We propose to determine the mechanisms of interaction of age, ceramides, cholesterols, gp120 and Tat that contribute to neuronal dysfunction and death in HAD...
  57. CYTOSKELETAL REGULATION OF ENDOTHELIAL CELL APOPTOSIS
    Irina Petrache; Fiscal Year: 2004
    ..abstract_text> ..
  58. Development of blood lipid biomarkers for Alzheimer's disease progression
    Michelle Mielke; Fiscal Year: 2008
    ..A major application would be as a surrogate or secondary outcome measure in clinical trials of emerging therapies for AD. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  59. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
    ..These studies should provide novel insights into the physiological importance of LCAT beyond its role in cholesterol esterification. ..
  60. BASIS FOR ALCOHOL AND COCAINE STROKES--ROLE OF MG2+
    Burton Altura; Fiscal Year: 2004
    ..Thus, aim 1 of the proposal seeks to determine the brain ceramides synthesized and released in situ by these drugs and to determine their relationship to changes in brain [Mg2+]i...
  61. HIV Mediated Dysfunction of Neural Progenitor Cells
    Norman Haughey; Fiscal Year: 2006
    ..Findings from these studies could identify novel therapeutic targets for the treatment of HIV-related neurological disease. ..
  62. Characterization of the Sch9 -Longevity Pathway in Yeast
    Robert Dickson; Fiscal Year: 2008
    ..This knowledge will help to provide a molecular basis for understanding human aging and longevity. ..