triglycerides

Summary

Top Publications

  1. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
  2. ncbi Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
  3. pmc Human fatty liver disease: old questions and new insights
    Jonathan C Cohen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Science 332:1519-23. 2011
  4. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
  5. ncbi Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
    Qiang Hu
    Department of Applied Biological Sciences, Arizona State University Polytechnic Campus, Mesa, AZ 85212, USA
    Plant J 54:621-39. 2008
  6. ncbi The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 7:941-6. 2001
  7. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
  8. pmc Molecular mediators of hepatic steatosis and liver injury
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9046, USA
    J Clin Invest 114:147-52. 2004
  9. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
  10. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008

Detail Information

Publications327 found, 100 shown here

  1. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
    ..of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic ..
  2. ncbi Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
    Jeffrey D Browning
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9046, USA
    Hepatology 40:1387-95. 2004
    ..In conclusion, the significant ethnic and sex differences in the prevalence of hepatic steatosis documented in this study may have a profound impact on susceptibility to steatosis-related liver disease...
  3. pmc Human fatty liver disease: old questions and new insights
    Jonathan C Cohen
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Science 332:1519-23. 2011
    ..Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies...
  4. ncbi Cardiovascular morbidity and mortality associated with the metabolic syndrome
    B Isomaa
    Department of Internal Medicine, Jakobstad Hospital, Finland
    Diabetes Care 24:683-9. 2001
    ..To estimate the prevalence of and the cardiovascular risk associated with the metabolic syndrome using the new definition proposed by the World Health Organization..
  5. ncbi Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
    Qiang Hu
    Department of Applied Biological Sciences, Arizona State University Polytechnic Campus, Mesa, AZ 85212, USA
    Plant J 54:621-39. 2008
    ....
  6. ncbi The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    T Yamauchi
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 7:941-6. 2001
    ..These data also indicate that the replenishment of adiponectin might provide a novel treatment modality for insulin resistance and type 2 diabetes...
  7. pmc Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, Twin Cities, St Paul, Minnesota, 55108, USA
    J Clin Invest 115:1343-51. 2005
    ..These quantitative metabolic data document that both elevated peripheral fatty acids and DNL contribute to the accumulation of hepatic and lipoprotein fat in NAFLD...
  8. pmc Molecular mediators of hepatic steatosis and liver injury
    Jeffrey D Browning
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9046, USA
    J Clin Invest 114:147-52. 2004
    ..metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides in the liver...
  9. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
  10. pmc Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice
    Catherine Postic
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 118:829-38. 2008
    ..This review discusses recent advances in the field...
  11. ncbi Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    John C LaRosa
    State University of New York Health Science Center, Brooklyn, NY 11203, USA
    N Engl J Med 352:1425-35. 2005
    ..We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD)...
  12. pmc FGF-21 as a novel metabolic regulator
    Alexei Kharitonenkov
    Lilly Research Laboratories, Division of Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Clin Invest 115:1627-35. 2005
    ..Therapeutic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in both ob/ob and db/db mice...
  13. pmc ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Nat Med 17:1076-85. 2011
    ..Here we show that lipolysis of cellular triglycerides by adipose triglyceride lipase (patatin-like phospholipase domain containing protein 2, encoded by Pnpla2; ..
  14. pmc Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides
    Katey J Rayner
    Marc and Ruti Bell Vascular Biology and Disease Program, Leon H Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nature 478:404-7. 2011
    ..resulting in a marked suppression of the plasma levels of very-low-density lipoprotein (VLDL)-associated triglycerides, a finding that has not previously been observed in mice...
  15. ncbi Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women
    Børge G Nordestgaard
    Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark
    JAMA 298:299-308. 2007
    Elevated nonfasting triglycerides indicate the presence of remnant lipoproteins, which may promote atherosclerosis.
  16. ncbi Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Prog Lipid Res 47:348-80. 2008
    ..The relationship between plasma lipoprotein concentrations and total plasma fatty acid composition, and the use of fatty acid ratios as indices of enzyme activity are also addressed...
  17. ncbi Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase
    Robert Zimmermann
    Institute of Molecular Biosciences, University of Graz, Graz, Austria
    Science 306:1383-6. 2004
    ..Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue...
  18. pmc Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    Quentin M Anstee
    Department of Medicine A, St Mary s Campus, Imperial College, London, UK
    Int J Exp Pathol 87:1-16. 2006
    ....
  19. pmc Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management
    M John Chapman
    European Atherosclerosis Society, INSERM UMR S939, Pitie Salpetriere University Hospital, Paris 75651, France
    Eur Heart J 32:1345-61. 2011
    ..for TRL and remnants, together with the epidemiological data suggestive of the association for circulating triglycerides and cardiovascular disease...
  20. ncbi An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
    L A Pennacchio
    Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 294:169-73. 2001
    ..to one-third of those in control mice; conversely, knockout mice lacking Apoav had four times as much plasma triglycerides as controls...
  21. ncbi Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
    Dawn L Brasaemle
    Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA
    J Lipid Res 48:2547-59. 2007
    ..A model is discussed whereby perilipin serves as a dynamic scaffold to coordinate the access of enzymes to the lipid droplet in a manner that is responsive to the metabolic status of the adipocyte...
  22. pmc Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study
    Logan Dumitrescu
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
    PLoS Genet 7:e1002138. 2011
    ..For the associations that did not generalize, differences in effect sizes, allele frequencies, and linkage disequilibrium offer clues to the next generation of association studies for these traits...
  23. ncbi Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..lipoprotein (LDL) cholesterol; near TRIB1, MLXIPL and ANGPTL3, with variants primarily associated with triglycerides; and a locus encompassing several genes near NCAN, with variants strongly associated with both triglycerides ..
  24. pmc Common variants at 30 loci contribute to polygenic dyslipidemia
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:56-65. 2009
    ..HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP...
  25. ncbi Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
    David Martins
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
    Arch Intern Med 167:1159-65. 2007
    ..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D...
  26. ncbi Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
    ..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
  27. pmc Genetic variants influencing circulating lipid levels and risk of coronary artery disease
    Dawn M Waterworth
    Genetics Division, GlaxoSmithKline R and D, King of Prussia, PA, USA
    Arterioscler Thromb Vasc Biol 30:2264-76. 2010
    ..We therefore conducted a genome-wide association study to identify novel genetic determinants of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides.
  28. pmc Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    Laura L Listenberger
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1010, USA
    Proc Natl Acad Sci U S A 100:3077-82. 2003
    ..Our findings support a model of cellular lipid metabolism in which unsaturated fatty acids serve a protective function against lipotoxicity though promotion of triglyceride accumulation...
  29. pmc MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1494-505. 2006
    ..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
  30. ncbi Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
    Lidia S Szczepaniak
    DW Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8899, USA
    Am J Physiol Endocrinol Metab 288:E462-8. 2005
    ..6%. Thus MRS provides a sensitive, quantitative, noninvasive method to measure HTGC and, when applied to a large urban US population, revealed a strikingly high prevalence of hepatic steatosis...
  31. pmc Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects
    Inger Ottestad
    Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway
    PLoS ONE 7:e42550. 2012
    ..The aim of this study was to investigate the effect of fish oil supplementation on the plasma lipidomic profile in healthy subjects...
  32. pmc Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors
    E B Rimm
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    BMJ 319:1523-8. 1999
    ..To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk...
  33. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    The association of triglycerides with incident cardiovascular disease remains controversial...
  34. pmc The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver
    Nicola L Beer
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK
    Hum Mol Genet 18:4081-8. 2009
    ..glucose metabolism and elevating concentrations of malonyl-CoA, a substrate for de novo lipogenesis, providing a mutational mechanism for the reported association of this variant with raised triglycerides and lower glucose levels.
  35. pmc Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase
    Natalie Krahmer
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 14:504-15. 2011
    ..Our results reveal a mechanism to maintain PC homeostasis at the expanding LD monolayer through targeted activation of a key PC synthesis enzyme...
  36. pmc Transcriptome sequencing and annotation of the microalgae Dunaliella tertiolecta: pathway description and gene discovery for production of next-generation biofuels
    Hamid Rismani-Yazdi
    Department of Chemical and Environmental Engineering, Yale University, New Haven, CT 06511, USA
    BMC Genomics 12:148. 2011
    ..Here we describe the sequencing and de novo transcriptome assembly for the non-model microalgae species, Dunaliella tertiolecta, and identify pathways and genes of importance related to biofuel production...
  37. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
    ..TAGs) and persisted after multivariable adjustment for age, sex, BMI, fasting glucose, fasting insulin, total triglycerides, and HDL cholesterol. A combination of 2 TAGs further improved diabetes prediction...
  38. ncbi Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
    Nicholas M Morton
    Endocrinology Unit, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Diabetes 53:931-8. 2004
    ..These data provide the first in vivo evidence that adipose 11 beta-HSD-1 deficiency beneficially alters adipose tissue distribution and function, complementing the reported effects of hepatic 11 beta-HSD-1 deficiency or inhibition...
  39. pmc Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis
    Daniel I Chasman
    Donald W Reynolds Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000730. 2009
    ..a genome-wide association study of 17 lipoprotein measures determined by NMR together with LDL-C, HDL-C, triglycerides, ApoA1, and ApoB in 17,296 women from the Women's Genome Health Study (WGHS)...
  40. pmc Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis
    Wei Zhong
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina 28081, USA
    Am J Pathol 180:998-1007. 2012
    ..loss and hepatic triglyceride gain, mice were first administered heavy water for 5 weeks to label adipose triglycerides with deuterium, and then pair-fed alcohol or control diet for 2 weeks...
  41. pmc Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women
    Kimber L Stanhope
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    J Clin Endocrinol Metab 96:E1596-605. 2011
    ....
  42. pmc Role of LXRs in control of lipogenesis
    J R Schultz
    Tularik Inc, South San Francisco, California 94080, USA
    Genes Dev 14:2831-8. 2000
    ..Complementary studies in cell culture and animals suggested that the increase in plasma lipids occurs via LXR-mediated induction of the sterol regulatory element-binding protein 1 (SREBP-1) lipogenic program...
  43. pmc Common variants associated with plasma triglycerides and risk for coronary artery disease
    Ron Do
    1 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 2 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA 4 Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 45:1345-52. 2013
    b>Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD)...
  44. pmc The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population
    Giorgio Bedogni
    Centro Studi Fegato Liver Research Center, Area Science Park, Basovizza, Trieste, and Department of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Trieste, Italy
    BMC Gastroenterol 6:33. 2006
    ..Fatty liver (FL) is the most frequent liver disease in Western countries. We used data from the Dionysos Nutrition & Liver Study to develop a simple algorithm for the prediction of FL in the general population...
  45. ncbi Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
    D J Peet
    Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 93:693-704. 1998
    ..These results demonstrate the existence of a physiologically significant feed-forward regulatory pathway for sterol metabolism and establish the role of LXR alpha as the major sensor of dietary cholesterol...
  46. ncbi Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism
    Martina Schweiger
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 281:40236-41. 2006
    ..Together, ATGL and HSL are responsible for more than 95% of the TG hydrolase activity present in murine WAT. Additional known or unknown lipases appear to play only a quantitatively minor role in fat cell lipolysis...
  47. pmc Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum
    Jay M Shockey
    U S Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, Louisiana 70124, USA
    Plant Cell 18:2294-313. 2006
    ..These data suggest that DGAT1 and DGAT2 have nonredundant functions in plants and that the production of storage oils, including those containing unusual fatty acids, occurs in distinct ER subdomains...
  48. pmc A role for phosphatidic acid in the formation of "supersized" lipid droplets
    Weihua Fei
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia
    PLoS Genet 7:e1002201. 2011
    ..In summary, our results provide important insights into how the size of LDs is determined and identify novel gene products that regulate phospholipid metabolism...
  49. pmc Algal lipid bodies: stress induction, purification, and biochemical characterization in wild-type and starchless Chlamydomonas reinhardtii
    Zi Teng Wang
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Eukaryot Cell 8:1856-68. 2009
    ..Nitrogen stress-induced LB production in C. reinhardtii has the hallmarks of a discrete pathway that should be amenable to additional genetic and culture condition manipulation...
  50. ncbi Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes 53:2087-94. 2004
    ..Of the NCEP criteria, waist circumference and triglycerides may best identify insulin resistance and visceral adiposity in individuals with a fasting plasma glucose <6...
  51. pmc Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    Sekar Kathiresan
    Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 40:189-97. 2008
    ..of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus)...
  52. pmc TIP47 functions in the biogenesis of lipid droplets
    Anna V Bulankina
    Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 185:641-55. 2009
    ..Suppression of TIP47 blocked LD maturation and decreased the incorporation of triacylglycerol into LDs. We conclude that TIP47 functions in the biogenesis of LDs...
  53. pmc Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia
    Ann C Skulas-Ray
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
    Am J Clin Nutr 93:243-52. 2011
    ..Studies using higher doses have shown evidence of reduced inflammation and improved endothelial function. Few studies have compared these doses...
  54. pmc Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 362:1082-9. 2010
    ..Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and type 2 diabetes mellitus. Whether this association has a genetic basis is unknown...
  55. pmc High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    Ryan T Birse
    NASCR Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Cell Metab 12:533-44. 2010
    ..We conclude that deregulation of insulin-TOR signaling due to a HFD is responsible for mediating the detrimental effects on metabolism and heart function...
  56. ncbi Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
    ..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins...
  57. pmc Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
    A Dahlqvist
    Scandinavian Biotechnology Research ScanBi AB, Herman Ehles Väg 2 S 26831 Svalôv, Sweden
    Proc Natl Acad Sci U S A 97:6487-92. 2000
    ..However, budding yeast PDAT and its relatives in fission yeast and Arabidopsis form a distinct branch within this protein superfamily, indicating that a separate PDAT enzyme arose at an early point in evolution...
  58. ncbi The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
    Alexei Kharitonenkov
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocrinology 148:774-81. 2007
    ..Systemic administration of FGF-21 reduced plasma glucose and triglycerides to near normal levels in genetically compromised diabetic rodents...
  59. ncbi Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles
    Aldo Grefhorst
    Laboratory of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Hospital Groningen, Hanzeplein 1, 9713 RB Groningen, The Netherlands
    J Biol Chem 277:34182-90. 2002
    ..We conclude that, in addition to raising high density lipoprotein cholesterol concentrations, pharmacological LXR activation in mice leads to development of hepatic steatosis and secretion of atherogenic, large TG-rich VLDL particles...
  60. ncbi Brown adipose tissue activity controls triglyceride clearance
    Alexander Bartelt
    Institute of Biochemistry and Molecular Biology II Molecular Cell Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Nat Med 17:200-5. 2011
    ..Cold exposure drastically accelerated plasma clearance of triglycerides as a result of increased uptake into BAT, a process crucially dependent on local LPL activity and ..
  61. ncbi A proposed model of fat packaging by exchangeable lipid droplet proteins
    Nathan E Wolins
    Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, Saint Louis, MO 63110, USA
    FEBS Lett 580:5484-91. 2006
    ..Different tissues express different complements of these lipid droplet proteins. Thus, the tissue-specific complement of these proteins determines how tissues manage lipid stores...
  62. pmc Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
    Chi Liang Eric Yen
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 49:2283-301. 2008
    Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and FAs in most living organisms...
  63. ncbi Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    Karen L Teff
    Monell Chemical Senses Center, University of Pennsylvania, Philadelphia 19104, USA
    J Clin Endocrinol Metab 89:2963-72. 2004
    ..05 vs. HGl). Consumption of HFr meals produced a rapid and prolonged elevation of plasma triglycerides compared with the HGl day (P < 0.005)...
  64. ncbi Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    Julia Araya
    Departamento de Nutricion, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Casilla 70058, Santiago 7, Santiago, Chile
    Clin Sci (Lond) 106:635-43. 2004
    ..study were to assess the levels of PUFA (polyunsaturated fatty acids) in liver total lipids, triacylglycerols (triglycerides) and phospholipids of NAFLD patients in relation to those in adipose tissue and hepatic indexes related to ..
  65. ncbi Lipolysis and lipid mobilization in human adipose tissue
    Max Lafontan
    INSERM U, Institut de Medecine Moleculaire de Rangueil, IFR BMT, Toulouse, France
    Prog Lipid Res 48:275-97. 2009
    ..The manipulation of lipolysis has therapeutic potential in the metabolic disorders frequently associated with obesity and probably in several inborn errors of metabolism...
  66. ncbi A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC
    Shinichi Usui
    Department of Biochemistry and Biophysics, Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Lipid Res 43:805-14. 2002
    ..969x + 5.44 (r = 0.990) for total cholesterol (mg/dl), y = 1.08x - 11.14 (r = 0.985) for total triglycerides (mg/dl), and y = 1.093x - 0.06 (r = 0.978) for the ratios of triglycerides to cholesterol (mg/mg)...
  67. ncbi Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    C J Sinal
    Laboratory of Metabolism, Division of Basic Sciences, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 102:731-44. 2000
    ..FXR/BAR null mice were distinguished from wild-type mice by elevated serum bile acid, cholesterol, and triglycerides, increased hepatic cholesterol and triglycerides, and a proatherogenic serum lipoprotein profile...
  68. ncbi Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins
    Weijia Kong
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing, 100050, China
    Nat Med 10:1344-51. 2004
    ..Oral administration of BBR in 32 hypercholesterolemic patients for 3 months reduced serum cholesterol by 29%, triglycerides by 35% and LDL-cholesterol by 25%...
  69. pmc 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice
    Anne Hermanowski-Vosatka
    Merck Research Laboratories, Merck and Company, Rahway, NJ 07065, USA
    J Exp Med 202:517-27. 2005
    ..Administration of a selective, potent 11beta-HSD1 inhibitor lowered body weight, insulin, fasting glucose, triglycerides, and cholesterol in diet-induced obese mice and lowered fasting glucose, insulin, glucagon, triglycerides, and ..
  70. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  71. pmc Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention
    Jesus Millan
    Hospital Universitario Gregorio Maranon, Madrid, Spain
    Vasc Health Risk Manag 5:757-65. 2009
    ....
  72. ncbi Cardiovascular risk factors and excess adiposity among overweight children and adolescents: the Bogalusa Heart Study
    David S Freedman
    Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Pediatr 150:12-17.e2. 2007
    ....
  73. pmc BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis
    R Daniel Rudic
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Biol 2:e377. 2004
    ..of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the ..
  74. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
    ..that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and ..
  75. ncbi Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila
    Sebastian Gronke
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg 11, 37077 Gottingen, Germany
    Cell Metab 1:323-30. 2005
    ..Their evolutionary conservation suggests Brummer/ATGL family members to be implicated in human obesity and establishes a basis for modeling mechanistic and therapeutic aspects of this disease in the fly...
  76. ncbi Lipid droplets in lipogenesis and lipolysis
    Nicole A Ducharme
    Center for Diabetes and Obesity Research, Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Endocrinology 149:942-9. 2008
    ..Future discovery likely will be driven by the exploitation of model organisms and by human genetic studies...
  77. pmc Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 95:13018-23. 1998
    ..The identification of this cDNA encoding a DGAT will greatly facilitate studies of cellular glycerolipid metabolism and its regulation...
  78. ncbi Storage lipid synthesis is non-essential in yeast
    Line Sandager
    Department of Crop Science, Swedish University of Agricultural Sciences, Box 44, S 230 53 Alnarp, Sweden
    J Biol Chem 277:6478-82. 2002
    ..The strain is devoid of both TAG and steryl esters, and fluorescence microscopy revealed that it also lacks lipid bodies. We conclude that neither storage lipids nor lipid bodies are essential for growth in yeast...
  79. ncbi Chylomicrons promote intestinal absorption of lipopolysaccharides
    Sarbani Ghoshal
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA
    J Lipid Res 50:90-7. 2009
    ..Chylomicron-associated LPS may contribute to postprandial inflammatory responses or chronic diet-induced inflammation in chylomicron target tissues...
  80. ncbi Adipose tissue as a buffer for daily lipid flux
    K N Frayn
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Diabetologia 45:1201-10. 2002
    ..Furthermore, this concept could provide a framework for understanding the action of the thiazolidinedione insulin-sensitizing agents...
  81. pmc Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    Sean B Joseph
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:7604-9. 2002
    ..These observations provide direct evidence for an atheroprotective effect of LXR agonists and support their further evaluation as potential modulators of human cardiovascular disease...
  82. ncbi Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
    Roberto Lupi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Diabetes 51:1437-42. 2002
    ..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated...
  83. ncbi Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose
    Mieke Van Hemelrijck
    King s College London, School of Medicine, Division of Cancer Studies, Cancer Epidemiology Unit, London, United Kingdom
    Cancer 117:2086-95. 2011
    In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose.
  84. ncbi Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    Jaspal S Kooner
    National Heart and Lung Institute, Imperial College London, UK
    Nat Genet 40:149-51. 2008
    We tested over 267,000 SNPs in 1,005 Northern Europeans and 248,000 in 1,006 Indian Asians for association with triglycerides and HDL cholesterol, with replication in 10,536 subjects...
  85. pmc Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 134:424-31. 2008
    ..The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD...
  86. ncbi Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast
    Anne C Nilsson
    Division of Applied Nutrition and Food Chemistry, Department of Food Technology, Engineering and Nutrition, Lund University, SE 22100 Lund, Sweden
    J Nutr 138:732-9. 2008
    ..The results provide evidence for a link between gut microbial metabolism and key factors associated with insulin resistance...
  87. ncbi Lipid droplets as dynamic organelles connecting storage and efflux of lipids
    Sven Olof Olofsson
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Wallenberg Laboratory, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Biochim Biophys Acta 1791:448-58. 2009
    ..article, we review the assembly and fusion of lipid droplets, and the processes involved in the secretion of triglycerides. Triglycerides are secreted from cells by two principally different processes...
  88. ncbi Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis
    Gabriel Perlemuter
    Liver Cancer and Molecular Virology, Institut National de la Santé et de la Recherche Médicale Unité 370, Faculte de Medecine Necker Enfants Malades, 75730 Paris Cedex 15, France
    FASEB J 16:185-94. 2002
    ....
  89. ncbi A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1
    Rainer Kalscheuer
    Institut fur Mikrobiologie, Westfalische Wilhelms Universitat Munster, Corrensstr 3, Germany
    J Biol Chem 278:8075-82. 2003
    ..The potential of WS/DGAT as a selective therapeutic target of mycobacterial infections is discussed...
  90. pmc Triglycerides and heart disease: still a hypothesis?
    Ira J Goldberg
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arterioscler Thromb Vasc Biol 31:1716-25. 2011
    The purpose of this article is to review the basic and clinical science relating plasma triglycerides and cardiovascular disease...
  91. pmc Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?
    Siobhán E McQuaid
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Diabetes 60:47-55. 2011
    ..It is not clear whether excess fat deposition in nonadipose tissue arises from excessive fatty acid delivery from adipose tissue or from impaired adipose tissue storage of ingested fat...
  92. pmc Triacylglycerol homeostasis: insights from yeast
    Sepp D Kohlwein
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 285:15663-7. 2010
    ..Based on these similarities, studies performed in yeast may provide further significant mechanistic insight into the molecular basis of triacylglycerol homeostasis and its important physiological roles in healthy and diseased cells...
  93. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
    ..These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults...
  94. ncbi Lipopenia and skin barrier abnormalities in DGAT2-deficient mice
    Scot J Stone
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 1900, USA
    J Biol Chem 279:11767-76. 2004
    The synthesis of triglycerides is catalyzed by two known acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes...
  95. ncbi Plasma lipoproteins: genetic influences and clinical implications
    Robert A Hegele
    Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, 406 100 Perth Drive, London, Ontario, Canada N6A 5K8
    Nat Rev Genet 10:109-21. 2009
    ..In addition to filling gaps in our understanding of plasma lipoprotein metabolism, the recent genetic advances will improve our ability to classify, diagnose and treat dyslipidaemias...
  96. ncbi Trends in serum lipids and lipoproteins of adults, 1960-2002
    Margaret D Carroll
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 294:1773-81. 2005
    ....
  97. ncbi Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis
    Josep A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 279:47066-75. 2004
    ..In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity...
  98. pmc Interactions of the apolipoprotein C-III 3238C>G polymorphism and alcohol consumption on serum triglyceride levels
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
    Lipids Health Dis 9:86. 2010
    ..The present study was undertaken to detect the interactions of the ApoC-III 3238C>G (rs5128) polymorphism and alcohol consumption on serum TG levels...
  99. ncbi The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese
    Toru Nabika
    Department of Laboratory Medicine, Shimane Medical University, 693 8501, Izumo, Japan
    Atherosclerosis 165:201-4. 2002
    ..0001). This result indicates that polymorphism in the apoAV gene influence serum TG in populations of different ethnicities...
  100. ncbi Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94143, USA
    J Biol Chem 276:38870-6. 2001
    ..DGAT2 is expressed in many tissues with high expression levels in the liver and white adipose tissue, suggesting that it may play a significant role in mammalian triglyceride metabolism...
  101. pmc Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study
    Rahul C Deo
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    PLoS Genet 5:e1000342. 2009
    ..Focusing on lipid profiles -- HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), and triglycerides (TG) -- we identified the lipoprotein lipase (LPL) locus as harboring variants that account for interethnic ..

Research Grants73

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..menstrual cycle and levels of high, low, and very-low density lipoproteins (HDL, LDL, VLDL, respectively) and triglycerides in serum will be measured as indicators of cardiovascular risk...
  2. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..in body composition were associated with decrease in plasma insulin area under the curve and plasma triglycerides. We attributed the adaptations in body composition and metabolic profile to an associated increase in plasma ..
  3. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..SCD1 has been shown to increase the synthesis and secretion of triglycerides following a high-saturated fat or high-carbohydrate diet...
  4. Hepatic Steatosis Modulation by Apo B Gene Transcription
    JANET DEHOFF SPARKS; Fiscal Year: 2010
    Over 50% of obese individuals with metabolic syndrome have increased hepatic triglycerides (TG) (steatosis) that predisposes them to non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) for which there is no consensus ..
  5. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..In addition, the amount and type of fat in the diet can regulate the levels of serum cholesterol and triglycerides, risk factors for atherosclerosis...
  6. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..on both serum OC and metabolic risk factors (including waist circumference, systolic blood pressure, fasting triglycerides, fasting HDL cholesterol, fasting plasma glucose, fasting plasma insulin, adiponectin concentrations and ..
  7. Role of Mitochondria in the Regulation of Iron metabolism by Alcohol
    DUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012
    ..stress down-regulates hepcidin transcription without causing changes in liver histology or an increase in triglycerides. Hepcidin is a circulatory peptide synthesized in the liver...
  8. Regulation of Hepatic SphK2 by Bile Acids: Effects on Lipid Metabolism
    HUIPING ROSE ZHOU; Fiscal Year: 2013
    ..The SphK2-/- mouse was also found to have an ~18-fold increase in serum triglycerides and a 2 to 5-fold decrease in both HDL and LDL as compared to wild-type control mice...
  9. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..These MUFA serve as precursors for the synthesis of hepatic lipids (triglycerides (TG) and cholesterol esters (CE) and thus play a role in the development of hepatic steatosis...
  10. Potential Mechanisms of Glucagon-like peptide-1 in Fatty Liver Disease
    Frank A Anania; Fiscal Year: 2010
    ..Insulin resistance is the primary pathophysiologic problem that results in a net accumulation of triglycerides in hepatocytes. At present there is limited therapy for fatty liver disease...
  11. Role of GDNF in the regulation of hepatic steatosis
    SHANTHI K SRINIVASAN; Fiscal Year: 2013
    ..Hepatic steatosis is a component of NAFLD, wherein there is accumulation of triglycerides in the liver...
  12. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..as modulating membrane fluidity, serving as signaling molecules, and providing energy storage in the form of triglycerides. Abnormal cholesterol and lipid levels have been linked to increasingly prevalent diseases, including ..
  13. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..ucOC levels at baseline predict changes in fasting glucose, A1C and insulin resistance, in lipids (serum triglycerides, total cholesterol, LDLc, HDLc, nonHDLc, and oxidized LDL), and in total fat mass and bone density measured by ..
  14. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ..These cellular structures are the primary storage depots for triglycerides in liver, adipose and muscle cells;and the source of triglycerides and cholesterol esters in serum lipoprotein ..
  15. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..We will compare the blood and liver levels of triglycerides and fatty acids with the circadian expression of procolipase and PLRP2...
  16. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..fatty liver disease (NAFLD) is a disorder of hepatic lipid homeostasis in which both cholesterol and triglycerides accumulate in hepatocytes...
  17. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ..Obesity alters adipose tissue function and impairs the efficient storage of triglycerides in adipocytes, leading to ectopic deposition of lipids and metabolic impairment in non-adipose tissues...
  18. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..evaluation of standard lipid markers (total cholesterol, low-density lipoprotein cholesterol (LDL-C), HDL-C, triglycerides), and novel lipid markers (apolipoprotein A-1 (Apo A-1) and Apo B100), as well as long-term use of statins in ..
  19. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..S. It consists of 3 of the following components: central obesity, high triglycerides, low HDL, abnormal blood pressure and impaired fasting glucose levels...
  20. Glucocorticoids, Stress and Blood Pressure Regulation
    Deborah A Scheuer; Fiscal Year: 2013
    ..generating risk factors including hypertension, abdominal obesity, hyperglycemia, insulin resistance, elevated triglycerides and cardiac arrhythmia...
  21. mTORC1-dependent regulation of the CycC/CDK8 complex
    Jeffrey E Pessin; Fiscal Year: 2013
    ..a pivotal activator of rate-limiting enzymes that are responsible for hepatic biosynthesis of fatty acids and triglycerides and it is the primary effecto of insulin-induced de novo lipogenesis in hepatocytes...
  22. Inflammation and Immunosuppression in Lung Cancer
    Cong Yan; Fiscal Year: 2013
    ..LAL hydrolyzes cholesteryl ester and triglycerides to generate free cholesterol and free fatty acids...
  23. Avoiding toxicity associated with MTP ablation
    M Mahmood Hussain; Fiscal Year: 2013
    ..Outcome measurements will involve changes in apoB-lipoproteins and hepatic enzymes in the plasma;hepatic triglycerides, esterified cholesterol, and free cholesterol;quantification of candidate mRNAs and proteins involved in ..
  24. Carbohydrate Regulation of Hepatic Gene Expression
    Kosaku Uyeda; Fiscal Year: 2010
    ..The liver is the principal organ responsible for the conversion of excess dietary carbohydrate into triglycerides. Ingestion of a high carbohydrate diet induces transcription of more than 15 genes involve in the conversion ..
  25. Control of liver autophagy by phosphatidic acid signaling
    GILBERT DIPAOLO; Fiscal Year: 2013
    ..Cellular lipids are generally stored as triglycerides in the form of lipid droplets and are hydrolyzed into fatty acids for energy supply during nutrient ..
  26. Vitamin D and Vascular Function in Obese Children
    Kumaravel Rajakumar; Fiscal Year: 2013
    ..HOMA-IR]);(4) metabolic syndrome risk factors (blood pressure, waist circumference, HDL cholesterol, triglycerides, and fasting blood glucose);(5) inflammatory markers (e.g...
  27. Metabolic Syndrome and Periodontitis
    ELIZABETH A KAYE; Fiscal Year: 2013
    ..provided by applicant): Metabolic syndrome is a group of metabolic abnormalities that includes elevated serum triglycerides, low level of high-density lipoprotein, high blood pressure, large waist circumference, microalbuminuria and ..
  28. GENETIC EPIDEMIOLOGY OF NONALCOHOLIC FATTY LIVER DISEASE
    Rohit Loomba; Fiscal Year: 2013
    ..between NAFLD and metabolic risk factors including hypertension (HTN), insulin resistance (IR), and elevated triglycerides (TG), which would be assessed by using multivariate generalized estimating equations after adjustment for age ..
  29. Impact of Cardiovascular and Weight Loss diets on Uric Acid and Gout Risk
    Hyon K Choi; Fiscal Year: 2013
    ..CV-metabolic comorbidities by leading to insulin-resistance and increased levels of plasma glucose, triglycerides, and LDL-cholesterol...
  30. Maternal Dietary Patterns and Child Weight Status
    Chantel L Martin; Fiscal Year: 2013
    ..during pregnancy and maternal nutrient biomarkers of fetal environment including glucose, insulin, leptin, triglycerides, and total cholesterol;(2) to examine the relationship between maternal dietary patterns during pregnancy and ..
  31. Regulation of Carbohydrate Metabolism and Lipogenesis
    Kosaku Uyeda; Fiscal Year: 2013
    ..The liver is the principal organ responsible for the conversion of excess dietary carbohydrate into triglycerides. Ingestion of a high carbohydrate diet induces transcription of more than 20 genes involved in the conversion ..
  32. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..and patients with this condition develop large amounts of proteinuria and elevated levels of plasma lipids (triglycerides and cholesterol)...
  33. Human Cell-Based Models of Primary Adipocyte Disorders
    CHAD ALBERT COWAN; Fiscal Year: 2013
    ..glucose intolerance, lowered plasma high-density-lipoprotein cholesterol, and accumulation of plasma triglycerides. They often develop diabetes mellitus, hypertriglyceridemia, and early- onset atherosclerosis...
  34. Role of FoxO1 in Lipid Metabolism
    REBECCA ANNE HAEUSLER; Fiscal Year: 2013
    ..constellation of lipid metabolic abnormalities that accelerate atherogenesis, including high serum triglycerides, low high-density lipoprotein cholesterol (HDL-C), and accumulation of liver fat, defects that are poorly ..
  35. Mouse Models to Characterize the Role of Lrp6 in Metabolic Syndrome
    Bart O Williams; Fiscal Year: 2010
    ..early age due to metabolic syndrome (a constellation of symptoms which includes high serum levels of LDL and triglycerides, hypertension, and diabetes)...
  36. Cardiovascular Health: Effects of the Social and Physical Environment
    Shakira Franco Suglia; Fiscal Year: 2013
    ..e., blood pressure, CRP, Hemoglobin A1c, BMI, waist circumference, total cholesterol, triglycerides, LDL, HDL, non-HDL cholesterol). The research goals of this proposal will be achieved with two projects...
  37. Pathogenic Mechanisms of Fatty Liver Disease
    Mohammad S Siddiqui; Fiscal Year: 2011
    ..When mice are fed a HFHC diet, hepatic triglycerides increase, producing ER stress and activation of SREBP-lc pathway, lnsig-1 and lnsig-2 are regulatory proteins ..
  38. Regulation of Maternal Fuel Supply and Neonatal Adiposity
    LINDA ANNE BARBOUR; Fiscal Year: 2013
    ..of our R56 pilot grant, we demonstrated a remarkably strong correlation between the change in maternal fasting triglycerides (TG) from early to late gestation and neonatal adiposity as measured by infant DXA (r=0.91;p=0...
  39. Obesity and Metabolic Risk Disparities: Underlying Food Environment Factors
    Penny Gordon-Larsen; Fiscal Year: 2013
    ..g., fasting glucose, waist circumference, systolic and diastolic blood pressure, triglycerides, and LDL and HDL cholesterol) over 25 years...
  40. ACCORD
    Faramarz Ismail Beigi; Fiscal Year: 2010
    ..effects on major CVD events of intensive glycemia control, of treatment to increase HDL-cholesterol and lower triglycerides (in the context of good LDL-C and glycemia control), and of intensive blood pressure control (in the context ..
  41. ACCORD
    Richard Grimm; Fiscal Year: 2010
    ..effects on major CVD events of intensive glycemia control, of treatment to increase HDL-cholesterol and lower triglycerides (in the context of good LDL-C and glycemia control), and of intensive blood pressure control (in the context ..
  42. Substituting Brown Rice for White Rice: Effect on Diabetes Risk Factors in India
    Mohan Viswanathan; Fiscal Year: 2012
    ..glucose, insulin, hemoglobin A1c, homeostasis model assessment for insulin resistance), dyslipidemia (i.e., triglycerides, total cholesterol, LDL- cholesterol, and HDL-cholesterol), and inflammation (i.e., C-reactive protein)...
  43. Role of Hepatic FoxO1 in Atherosclerosis
    REBECCA ANNE HAEUSLER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dyslipidemia, including excess production and secretion of triglycerides and cholesterol by the liver, is a prominent metabolic abnormality of type 2 diabetes that can lead to the development of ..
  44. Enhancing Energy Expending Adipocytes in White Adipose Tissue
    STEPHEN ROBERT FARMER; Fiscal Year: 2013
    ..of adipose tissue in obese individuals is a direct cause of these diseases due to an excessive accumulation of triglycerides (TGs) within white adipose (WAT) adipocytes...
  45. Lipid genotypes, phenotypes, and colorectal adenomas: Elucidating mechanisms
    Polly A Newcomb; Fiscal Year: 2013
    ..to blood levels of total cholesterol (TC), high- and low-density lipoprotein (HDL, LDL) cholesterol, and triglycerides (TG)...
  46. Identification of Causal Variants at Novel GWAS Loci Associated with Lipid Traits
    DANIEL JAMES RADER; Fiscal Year: 2010
    ..lipids including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) are highly heritable risk factors for cardiovascular disease...
  47. Interactions of Lipoproteins with the Vascular Wall
    JOHN CALVERT RUTLEDGE; Fiscal Year: 2010
    Elevation of blood triglycerides, primarily as triglyceride-rich lipoproteins (TGRL), is a known risk factor for the development of atherosclerotic cardiovascular disease and increasingly linked to vascular inflammation...
  48. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton T Rubin; Fiscal Year: 2012
    ..The status of marrow, fat and bone, and level of triglycerides and free fatty acid in the serum, liver, muscle and adipose tissue, will be quantified and compared to ..
  49. Metabolic Consequences of bariatric surgery on pregnant and lactating rats and th
    Bernadette E Grayson; Fiscal Year: 2013
    ..the "metabolic syndrome" which includes insulin resistance, impaired glucose tolerance and hypertension, triglycerides and cholesterol2...
  50. Outcomes of Community Naturopathic Medical Care for Type 2 Diabetes
    Daniel C Cherkin; Fiscal Year: 2010
    ..Changes in HbA1c (primary outcome) and in body mass index, lipids, blood pressure and triglycerides over the one year treatment period will be measured. Patient-centered outcomes (e.g...
  51. Effects of Yoga on CVD Risk Factors among African Americans: Jackson Heart Study
    Gailen D Marshall; Fiscal Year: 2013
    ..more likely than whites to have risk factors for CVD, such as hypertension and elevated levels of cholesterol, triglycerides, and HbA1c...
  52. Prenatal exposure to high-fat diets promotes alcohol preference in the offspring
    Miriam E Bocarsly; Fiscal Year: 2012
    ..1. Lastly, studies indicate that elevated triglycerides (TG) during gestation might be responsible for the behavior seen in Exp...
  53. FATTY ACID TRANSPORT IN EUKARYOTES
    CONCETTA CHRISTINE DIRUSSO; Fiscal Year: 2010
    ..free fatty acids, which in turn lead to increased fatty acid internalization and ectopic accumulation of triglycerides. The correlation between chronically elevated plasma free fatty acids and triglycerides with the development ..
  54. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    ..These populations demonstrate reduced VLDL-triglycerides and LDL-cholesterol...
  55. Nutrition Intervention: Metabolic Complications of HIV+
    Margo Woods; Fiscal Year: 2006
    ..This syndrome is characterized by hyperlipidemia, lipodystrophy and insulin resistance. Elevated triglycerides are a common observation with or without hypercholesterolemia...
  56. Adenovirus & Human Obesity - Longitudinal & Twin Studies
    Richard Atkinson; Fiscal Year: 2001
    ..of increased visceral and total body fat deposition, with paradoxically decreased serum cholesterol (CHOL) and triglycerides (TG), in chickens, mice, and monkeys...
  57. The Effects of Docosahexaenoic acid (DHA) on fetal cardiac outcomes
    Kathleen M Gustafson; Fiscal Year: 2010
    ..In adults, DHA has been shown to lower triglycerides and is important to cardiovascular health and autonomic control, lowering heart rate (HR) and blood pressure ..
  58. CORONARY ARTERY DISEASE AND POSTPRANDIAL LIPOPROTEINS
    Henry Ginsberg; Fiscal Year: 1992
    ..We propose therefore: 1. To determine if increased postprandial levels of plasma triglycerides are associated with the presence of coronary artery disease, and if so, if this association is independent of ..
  59. ANIMAL MODELS OF VIRUS INDUCED OBESITY
    Richard Atkinson; Fiscal Year: 2000
    ..AD-36, produce a syndrome of visceral obesity in chickens, with paradoxical decreased serum cholesterol and triglycerides. In two preliminary studies, 19% of obese humans had serum antibodies to SMAM-1 in Bombay, and 17% had ..
  60. DIETARY TREATMENT OF DIABETES MELITUS--META ANALYSIS
    Zung Tran; Fiscal Year: 1991
    ..and the lipid profile in NIDDM patients favorably by regulating blood glucose, by reducing total cholesterol, triglycerides, and low density lipoprotein-cholesterol and by elevating high density lipoprotein-cholesterol levels...
  61. Adipose Tissue-specific Angiogenesis and Insulin Sensitivity
    Silvia Corvera; Fiscal Year: 2009
    ..Insulin resistance is ameliorated when the capacity of adipose cells to store and retain lipids in the form of triglycerides is enhanced, either by changes in cell function or number...
  62. NUTRITION AND LIPOPROTEIN LIPASE-MOLECULAR MECHANISMS
    SUSAN FRIED; Fiscal Year: 1992
    ..A major regulator of fat deposition is the rate of uptake of circulating triglycerides which is controlled by the activity of the enzyme lipoprotein lipase (LPL)...
  63. Parenteral Medium Chain Triglycerides in the Premature
    Eberhard Schmidt Sommerfeld; Fiscal Year: 2002
    ..to enteral feeding intolerance have a limited capacity to utilize energy in the form of glucose and long-chain triglycerides (LCT)...
  64. RISK OF CHD IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
    Evelyn Talbott; Fiscal Year: 2005
    ..and determined that PCOS cases had a profile that conferred increased cardiovascular risk (increased LDLc, triglycerides, and waist/hip ratio, obesity, decreased HDLc, hyperinsulinemia, and increased diastolic and systolic blood ..