eicosapentaenoic acid

Summary

Summary: Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.

Top Publications

  1. ncbi Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    Mitsuhiro Yokoyama
    Kobe University, Kobe, Japan
    Lancet 369:1090-8. 2007
  2. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
  3. pmc Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish
    Lucy M Browning
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom
    Am J Clin Nutr 96:748-58. 2012
  4. ncbi Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials
    Sang Mi Kwak
    Center for Cancer Prevention and Detection, Ilsan, Republic of Korea
    Arch Intern Med 172:686-94. 2012
  5. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
  6. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
  7. pmc Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
    FASEB J 23:1946-57. 2009
  8. ncbi Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats
    Simon C Dyall
    Neuroscience Centre, ICMS, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, United Kingdom
    J Neurosci Res 88:2091-102. 2010
  9. pmc Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression
    M Elizabeth Sublette
    New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 72:1577-84. 2011
  10. ncbi Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review
    Terry A Jacobson
    Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Faculty Office Building, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    J Clin Lipidol 6:5-18. 2012

Detail Information

Publications319 found, 100 shown here

  1. ncbi Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    Mitsuhiro Yokoyama
    Kobe University, Kobe, Japan
    Lancet 369:1090-8. 2007
    ..We aimed to test the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who ..
  2. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
    ..Together, these results identify new active components for postexudate resolution traffic, and demonstrate that RvE1 and PD1 are potent agonists for resolution of inflamed tissues...
  3. pmc Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish
    Lucy M Browning
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom
    Am J Clin Nutr 96:748-58. 2012
    Estimation of the intake of oily fish at a population level is difficult. The measurement of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in biological samples may provide a useful biomarker of intake.
  4. ncbi Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials
    Sang Mi Kwak
    Center for Cancer Prevention and Detection, Ilsan, Republic of Korea
    Arch Intern Med 172:686-94. 2012
    ..Using a meta-analysis, we investigated the efficacy of eicosapentaenoic acid and docosahexaenoic acid in the secondary prevention of CVD.
  5. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..which possess the most potent immunomodulatory activities, and among the omega-3 PUFA, those from fish oil-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)--are more biologically potent than alpha-linolenic acid (ALA)...
  6. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
    Red blood cell (RBC) levels of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA, the omega-3 index, expressed as a percent of total fatty acids) are inversely related to risk for cardiovascular disease (CVD)...
  7. pmc Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
    FASEB J 23:1946-57. 2009
    ..Taken together, these findings uncover beneficial actions of omega-3-PUFAs and their bioactive lipid autacoids in preventing obesity-induced insulin resistance and hepatic steatosis...
  8. ncbi Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats
    Simon C Dyall
    Neuroscience Centre, ICMS, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, United Kingdom
    J Neurosci Res 88:2091-102. 2010
    ..The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have neuroprotective effects in the aged brain and are endogenous ..
  9. pmc Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression
    M Elizabeth Sublette
    New York State Psychiatric Institute, New York, NY 10032, USA
    J Clin Psychiatry 72:1577-84. 2011
    ..Recent meta-analyses ascribe discrepancies to differential effects of eicosapentaenoic acid (EPA) versus docosahexaenoic acid (DHA) and to diagnostic heterogeneity...
  10. ncbi Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review
    Terry A Jacobson
    Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Faculty Office Building, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    J Clin Lipidol 6:5-18. 2012
    ..exploratory, hypothesis-generating literature review, we evaluated potentially differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on low-density lipoprotein cholesterol (LDL-C), high-density ..
  11. ncbi EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials
    Julian G Martins
    Academy of Nutritional Medicine, 80 Commercial End, Swaffham Bulbeck, Cambridge CB25 0NE, UK
    J Am Coll Nutr 28:525-42. 2009
    ..However, the results of randomized controlled trials are mixed and controversy exists as to whether either eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) or both are responsible for the reported benefits.
  12. ncbi Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    Martha Clare Morris
    Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:940-6. 2003
    ..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease...
  13. ncbi Molecular circuits of resolution: formation and actions of resolvins and protectins
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:4345-55. 2005
    ..These results characterize the first molecular resolution circuits and their major components activated by specific novel lipid mediators (i.e., resolvin E1 and 10,17S-docosatriene) to promote resolution...
  14. ncbi Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocytes
    Justine M Tishinsky
    Department of Human Health and Nutritional Sciences, Animal Science and Nutrition Building, University of Guelph, Guelph, Ontario, Canada
    Obesity (Silver Spring) 19:262-8. 2011
    ..Isolated human adipocytes were cultured for 48 h with 100 µmol/l eicosapentaenoic acid (C20:5n-3, EPA), docosahexaenoic acid (C22:6n-3, DHA), palmitic acid (C16:0), 100 µmol/l EPA plus 100 µ..
  15. ncbi Efficacy and safety of eicosapentaenoic acid ethyl ester (AMR101) therapy in statin-treated patients with persistent high triglycerides (from the ANCHOR study)
    Christie M Ballantyne
    Baylor College of Medicine and the Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA
    Am J Cardiol 110:984-92. 2012
    AMR101 is an ω-3 fatty acid agent containing ≥96% pure icosapent-ethyl, the ethyl ester of eicosapentaenoic acid. The efficacy and safety of AMR101 were evaluated in this phase 3, multicenter, placebo-controlled, randomized, double-..
  16. pmc Eicosapentaenoic acid demethylates a single CpG that mediates expression of tumor suppressor CCAAT/enhancer-binding protein delta in U937 leukemia cells
    Veronica Ceccarelli
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06126, Italy
    J Biol Chem 286:27092-102. 2011
    ..PUFAs affected proliferation; eicosapentaenoic acid (EPA) was the most potent on cell cycle progression...
  17. ncbi Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6703 HD Wageningen, Netherlands
    Am J Clin Nutr 90:415-24. 2009
    ..Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown...
  18. ncbi Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis
    Charles N Serhan
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Prostaglandins Other Lipid Mediat 73:155-72. 2004
    ..Recently, novel mediators generated from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that displayed potent bioactions were first identified in resolving ..
  19. ncbi Distribution, interconversion, and dose response of n-3 fatty acids in humans
    Linda M Arterburn
    Martek Biosciences Corporation, Columbia, MD, USA
    Am J Clin Nutr 83:1467S-1476S. 2006
    ..b>Eicosapentaenoic acid (EPA) but not DHA concentrations in plasma increase in response to dietary EPA...
  20. ncbi Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Immunol 178:3912-7. 2007
    Resolvin E1 (RvE1) is a potent anti-inflammatory and proresolving mediator derived from omega-3 eicosapentaenoic acid generated during the resolution phase of inflammation...
  21. pmc Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers
    Stine M Ulven
    Faculty of Health, Nutrition, and Management, Akershus University College, Lillestrøm, Norway
    Lipids 46:37-46. 2011
    ..Krill oil and fish oil thus represent comparable dietary sources of n-3 PUFAs, even if the EPA + DHA dose in the krill oil was 62.8% of that in the fish oil...
  22. ncbi RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis
    H Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, Massachusetts, USA
    FASEB J 20:401-3. 2006
    ..Consistent with these potent actions, topical application of RvE1 in rabbit periodontitis conferred dramatic protection against inflammation induced tissue and bone loss associated with periodontitis...
  23. pmc Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1197-204. 2000
    ..The generation of these and related compounds provides a novel mechanism(s) for the therapeutic benefits of omega-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases...
  24. ncbi Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety
    Shawna L Lemke
    Monsanto Company, St Louis, MO 63167, USA
    Am J Clin Nutr 92:766-75. 2010
    ..The benefits of omega-3 (n-3) long-chain polyunsaturated fatty acids to heart health are well established. Stearidonic acid (SDA, 18:4n-3) may contribute to these benefits...
  25. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    ..Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain...
  26. ncbi Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids
    Jing Cao
    University of Minnesota, Minneapolis, MN 55455, USA
    Clin Chem 52:2265-72. 2006
    The sum of eicosapentaenoic acid (EPA, 20:5 omega3) and docosahexaenoic acid (DHA, 22:6 omega3) in erythrocyte membranes, termed the omega-3 index, can indicate suboptimal intake of omega-3 fatty acids, a risk factor for cardiovascular ..
  27. pmc Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:7671-6. 2005
    ..acid) is an antiinflammatory lipid mediator derived from omega-3 fatty acid eicosapentaenoic acid (EPA)...
  28. pmc Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:713-22. 2005
    The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial effects in a range of human disorders associated with inflammation including cardiovascular disease...
  29. ncbi Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation
    Nishan S Kalupahana
    Department of Animal Science, Obesity Research Center, University of Tennessee, Knoxville, TN 37996, USA
    J Nutr 140:1915-22. 2010
    We investigated the effects of eicosapentaenoic acid (EPA) on prevention (P) and reversal (R) of high saturated-fat (HF) diet-induced obesity and glucose-insulin homeostasis...
  30. pmc Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation
    Sungwhan F Oh
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115 5727, USA
    J Clin Invest 121:569-81. 2011
    ..are antiinflammatory and pro-resolving lipid mediators derived from the ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) that actively clear inflammation to promote tissue homeostasis...
  31. ncbi Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] trial)
    Harold E Bays
    Louisville Metabolic and Atherosclerosis Research Center, Kentucky, USA
    Am J Cardiol 108:682-90. 2011
    AMR101 is an omega-3 fatty acid agent containing ≥96% eicosapentaenoic acid ethyl ester and no docosahexaenoic acid...
  32. pmc Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition
    Ramzi J Khairallah
    Division of Cardiology and Department of Medicine, University of Maryland, 20 Penn Street, HSF2, Room S022, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1797:1555-62. 2010
    Treatment with the omega-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) exerts cardioprotective effects, and suppresses Ca2+-induced opening of the mitochondrial permeability transition ..
  33. ncbi Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis
    Nicholas J West
    Section of Molecular Gastroenterology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    Gut 59:918-25. 2010
    The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) has anticolorectal cancer activity in vitro and in preclinical models...
  34. ncbi Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women
    Kevin C Maki
    Provident Clinical Research, Bloomington, IN 47403, USA Provident Clinical Research, Glen Ellyn, IL 60137, USA
    Nutr Res 29:609-15. 2009
    Antarctic krill, also known as Euphausia superba, is a marine crustacean rich in both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
  35. ncbi Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Reprod Nutr Dev 45:581-97. 2005
    ..Increasing alphaLNA intake for a period of weeks to months results in an increase in the proportion of eicosapentaenoic acid (EPA; 20:5n-3) in plasma lipids, in erythrocytes, leukocytes, platelets and in breast milk but there is no ..
  36. ncbi Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action
    Hemant Poudyal
    School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia
    Prog Lipid Res 50:372-87. 2011
    ..human, animal, and cell culture studies show that n-3 fatty acids, especially α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), reduce the risk factors of cardiovascular diseases...
  37. ncbi Omega-3 polyunsaturated fatty acids and cardiovascular diseases
    Carl J Lavie
    Department of Cardiovascular Diseases, Ochsner Medical Center, New Orleans, LA 70121 2483, USA
    J Am Coll Cardiol 54:585-94. 2009
    ..of omega-3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after ..
  38. ncbi An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids
    Mónica Venegas-Calerón
    Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Prog Lipid Res 49:108-19. 2010
    It is now accepted that omega-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA; 20:5Delta5,8,11,14,17) and docosahexaenoic acid (DHA, 22:6Delta4,7,10,13,16,19) play important roles in a number of aspects of human ..
  39. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  40. ncbi Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study
    Boukje Maria van Gelder
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, Netherlands
    Am J Clin Nutr 85:1142-7. 2007
    ..Indications have been seen of a protective effect of fish consumption and the intake of n-3 fatty acids on cognitive decline. However, studies are scarce and results inconsistent...
  41. ncbi Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men*
    Graham C Burdge
    Institute of Human Nutrition, Level C, West Wing, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Br J Nutr 88:355-63. 2002
    ..The time scale of conversion of [13C]ALNA to eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) suggested that the liver was the principal site of ALNA desaturation ..
  42. ncbi The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study
    Chih Chiang Chiu
    Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Department of Psychiatry, Taipei Medical University, Taipei, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1538-44. 2008
    ..03), which was not observed in those with Alzheimer's disease. Higher proportions of eicosapentaenoic acid on RBC membranes were also associated with better cognitive outcome (p=0.003)...
  43. ncbi Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
    Naoki Tanaka
    Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan
    J Clin Gastroenterol 42:413-8. 2008
    ..Although eicosapentaenoic acid (EPA), one of the major components of n-3 polyunsaturated fatty acids, is widely used as an antilipidemic ..
  44. ncbi Dietary modification of inflammation with lipids
    Philip C Calder
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, UK
    Proc Nutr Soc 61:345-58. 2002
    The n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are found in high proportions in oily fish and fish oils. The n-3 PUFA are structurally and functionally distinct from the n-6 PUFA...
  45. ncbi Cloning and functional characterization of Phaeodactylum tricornutum front-end desaturases involved in eicosapentaenoic acid biosynthesis
    Frederic Domergue
    Institut fur Allgemeine Botanik, Universitat Hamburg, Hamburg, Germany
    Eur J Biochem 269:4105-13. 2002
    Phaeodactylum tricornutum is an unicellular silica-less diatom in which eicosapentaenoic acid accumulates up to 30% of the total fatty acids...
  46. ncbi Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men
    T A Mori
    Department of Medicine, University of Western Australia, and The West Australian Heart Research Institute, Perth, Australia
    Circulation 102:1264-9. 2000
    Recent evidence supports differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the 2 major omega3 fatty acids of marine origin, on blood pressure in humans and vascular reactivity in adult spontaneously ..
  47. ncbi Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men
    Dinka Rees
    The Rowett Research Institute, Aberdeen, United Kingdom
    Am J Clin Nutr 83:331-42. 2006
    ..Increasing intakes of long-chain n-3 polyunsaturated fatty acids (PUFAs) can decrease markers of immunity. However, dose- and age-related responses have not been identified...
  48. pmc Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study
    James V Pottala
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Circ Cardiovasc Qual Outcomes 3:406-12. 2010
    ..The purpose of this study was to determine the extent to which baseline blood n-3 FA levels are associated with reduced risk for all-cause mortality in patients with stable coronary heart disease...
  49. ncbi Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica
    Zhixiong Xue
    Industrial Biosciences, E I Du Pont de Nemours and Company, Wilmington, Delaware, USA
    Nat Biotechnol 31:734-40. 2013
    The availability of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is currently limited because they are produced mainly by marine fisheries that cannot keep pace with the demands of the growing market ..
  50. ncbi Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis
    Eric Tjonahen
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Chem Biol 13:1193-202. 2006
    ..of resolvins consists of omega-3 fatty acid-derived mediators, including E series resolvins generated from eicosapentaenoic acid (EPA), and carry potent anti-inflammatory properties...
  51. pmc Formation of highly reactive cyclopentenone isoprostane compounds (A3/J3-isoprostanes) in vivo from eicosapentaenoic acid
    Joshua D Brooks
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Biol Chem 283:12043-55. 2008
    ..b>Eicosapentaenoic acid (EPA) is one of the most abundant omega-3 fatty acids in fish oil, but the mechanism(s) by which EPA ..
  52. ncbi Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements
    Mélanie Plourde
    Research Center on Aging, Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, 1036 Belvedere St, South, Sherbrooke, QC J1H 4C4, Canada
    Appl Physiol Nutr Metab 32:619-34. 2007
    ..As a result, there is uncertainty about the potential benefits of ALA versus eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA)...
  53. ncbi Docosahexaenoic acid increases cellular adiponectin mRNA and secreted adiponectin protein, as well as PPARγ mRNA, in 3T3-L1 adipocytes
    Richard T Oster
    Department of Human Health and Nutritional Sciences, Animal Science and Nutrition Building, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 35:783-9. 2010
    ..Long-chain n-3 fatty acids eicosapentaenoic acid (20:5n-3; EPA) and docosahexaenoic acid (22:6n-3; DHA) may be involved in adiponectin regulation as they ..
  54. ncbi Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans
    S Grimsgaard
    Institute of Community Medicine, University of Tromsø, Norway
    Am J Clin Nutr 68:52-9. 1998
    The hemodynamic effects of highly purified eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) have not been evaluated in humans...
  55. pmc Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium
    Ramzi J Khairallah
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 335:155-62. 2010
    Intake of fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) prevents heart failure; however, the mechanisms are unclear...
  56. ncbi Lack of benefit of dietary advice to men with angina: results of a controlled trial
    M L Burr
    University of Wales College of Medicine, Cardiff, UK
    Eur J Clin Nutr 57:193-200. 2003
    ..To see whether mortality among men with angina can be reduced by dietary advice...
  57. ncbi n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ..the relation of the dietary intake of n-3 polyunsaturated fatty acids, ie, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from fatty fish and alpha-linolenic acid from vegetable oils, with ischemic heart disease among ..
  58. ncbi Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men
    T A Mori
    Department of Medicine, The University of Western Australia and The West Australian Heart Research Institute, Perth
    Am J Clin Nutr 71:1085-94. 2000
    ..Regular consumption of n-3 fatty acids of marine origin can improve serum lipids and reduce cardiovascular risk...
  59. ncbi Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Park 5, Room 150, 12420 Parklawn Drive, Rockville, MD 20892, USA
    J Affect Disord 69:15-29. 2002
    ..We postulated that the DHA content of mothers' milk and seafood consumption would both predict prevalence rates of postpartum depression across countries...
  60. ncbi Towards the production of high levels of eicosapentaenoic acid in transgenic plants: the effects of different host species, genes and promoters
    Bifang Cheng
    Bioriginal Food and Science Corporation, 110 Gymnasium Place, Saskatoon, SK S7N 0W9, Canada
    Transgenic Res 19:221-9. 2010
    b>Eicosapentaenoic acid (EPA, 20:5n-3) plays an important role in many aspects of human health...
  61. ncbi Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk
    Cecilia Samieri
    INSERM, U897, Equipe Epidémiologie de Nutrition et des Comportements Alimentaires, Bordeaux, France
    Am J Clin Nutr 88:714-21. 2008
    ..Plasma n-3 PUFAs have been shown to be inversely related to the risk of dementia and to depression, which is frequently associated with dementia...
  62. ncbi Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects
    Trevor A Mori
    Department of Medicine, The University of Western Australia, The West Australian Heart Research Institute and The Western Australian Institute for Medical Research, Perth, Western Australia 6000, Australia
    Free Radic Biol Med 35:772-81. 2003
    ..This study aimed to assess the effects of supplementation with purified eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), the two major n-3 fatty acids, on urinary F2-isoprostanes and markers ..
  63. ncbi Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects
    Michiko Itoh
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Arterioscler Thromb Vasc Biol 27:1918-25. 2007
    ..Here we investigated the effect of highly purified eicosapentaenoic acid (EPA) on production of adiponectin, the only established antiatherogenic and antiinflammatory ..
  64. ncbi Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo
    Hatice Hasturk
    Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118, USA
    J Immunol 179:7021-9. 2007
    Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapentaenoic acid that acts locally to stop leukocyte recruitment and promote resolution...
  65. ncbi Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet
    P Flachs
    Department of Adipose Tissue Biology, Institute of Physiology, Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic
    Diabetologia 49:394-7. 2006
    Diets rich in n-3 polyunsaturated fatty acids, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against insulin resistance and obesity in rodents and increase insulin sensitivity in healthy humans...
  66. ncbi Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid
    Sinéad M Weldon
    Nutrigenomics Research Group, Department of Clinical Medicine, Institute of Molecular Medicine, Trinity Center for Health Sciences, St James s Hospital, Dublin 8, Ireland
    J Nutr Biochem 18:250-8. 2007
    ..of these studies have employed heterogeneous blends of long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which preclude examination of the individual effects of LC n-3 PUFA...
  67. ncbi (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells
    Patricia D Schley
    Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Nutr 137:548-53. 2007
    To determine the mechanism by which the (n-3) fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) decrease proliferation and induce apoptosis in MDA-MB-231 human breast cancer cells, we examined the effects of EPA ..
  68. pmc Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil
    Jan Philipp Schuchardt
    Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany
    Lipids Health Dis 10:145. 2011
    ..Superior bioavailability has been suggested for phospholipid (PL) bound omega-3 FA in krill oil, but identical doses of different chemical forms have not been compared...
  69. ncbi Molecular recognition of fatty acids by peroxisome proliferator-activated receptors
    H E Xu
    Glaxo Wellcome Research and Development, Research Triangle Park, North Carolina 27709, USA
    Mol Cell 3:397-403. 1999
    ..We report the crystal structure of the PPAR delta ligand-binding domain (LBD) bound to either the FA eicosapentaenoic acid (EPA) or the synthetic fibrate GW2433...
  70. ncbi Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans
    T A Mori
    Department of Medicine, University of Western Australia, and The West Australian Heart Research Institute, Perth, Australia
    Hypertension 34:253-60. 1999
    Animal studies suggest that the 2 major omega3 fatty acids found in fish, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may have differential effects on blood pressure (BP) and heart rate (HR)...
  71. ncbi Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides
    Kathy Musa-Veloso
    Cantox Health Sciences International, Mississauga, Ontario, Canada
    Nutr Rev 68:155-67. 2010
    The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical ..
  72. ncbi Eicosapentaenoic acid prevents LPS-induced TNF-alpha expression by preventing NF-kappaB activation
    Yan Zhao
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506 0054, USA
    J Am Coll Nutr 23:71-8. 2004
    ..NF-kappaB is kept in an inactive form in the cytoplasm by IkappaB, the inhibitory subunit of NF-kappaB complex. Phosphorylation and subsequent degradation of IkappaB lead to NF-kappaB activation...
  73. ncbi Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA
    Scott D Doughman
    Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Nilayam, India
    Curr Diabetes Rev 3:198-203. 2007
    ....
  74. pmc Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids
    Z Makhoul
    Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Eur J Clin Nutr 65:808-17. 2011
    ..N-3 fatty acids are associated with favorable, and obesity with unfavorable, concentrations of chronic disease risk biomarkers...
  75. ncbi Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia
    J B Hansen
    Department of Medicine, Tromsø University Hospital, Norway
    Lipids 33:131-8. 1998
    Fourteen healthy volunteers were randomly allocated to receive 4 g highly purified ethyl esters of eicosapentaenoic acid (EPA) (95% pure, n = 7) or docosahexaenoic acid (DHA) (90% pure, n = 7) daily for 5 wk in supplement to their ..
  76. pmc Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia
    R A Murphy
    Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, 4 126 Li Ka Shing Center, Edmonton, AB T6G 2E1, Canada
    Br J Cancer 105:1469-73. 2011
    ..b>Eicosapentaenoic acid, an n-3 polyunsaturated fatty acid found in fish, has been studied for its role as an anti-cachexia ..
  77. pmc Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    Eric L Campbell
    Mucosal Inflammation Program, Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:14298-303. 2010
    ..Together, these data implicate a previously unappreciated role for ALPI in RvE1-mediated inflammatory resolution...
  78. ncbi Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation
    Emilie Mas
    School of Medicine and Pharmacology, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia
    Clin Chem 58:1476-84. 2012
    Resolvins and protectins are families of local lipid mediators generated from the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) during self-limited resolution of inflammation...
  79. ncbi Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells
    Rozangela Verlengia
    Methodist University of Piracicaba, Faculty of Physical Education, Faculdade de Educação Física, Sao Paulo, Brazil
    J Nutr Biochem 15:657-65. 2004
    Comparative effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acid on Jurkat T cells were investigated...
  80. ncbi Eicosapentaenoic acid interventions in schizophrenia: meta-analysis of randomized, placebo-controlled studies
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s College London, London, United Kingdom
    J Clin Psychopharmacol 32:179-85. 2012
    Omega-3 fatty acids, in particular, eicosapentaenoic acid (EPA) have been suggested as augmentation strategies in the treatment of schizophrenia and related psychosis...
  81. ncbi Impact of n-3 fatty acids on endothelial function: results from human interventions studies
    Sarah Egert
    Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Bonn, Germany
    Curr Opin Clin Nutr Metab Care 14:121-31. 2011
    ..This review summarizes recent findings on the effects of marine [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)] and plant [alpha-linolenic acids (ALA)] n-3 polyunsaturated fatty acids ..
  82. ncbi Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice
    Kenji Nakajima
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Kobe, Japan
    Arterioscler Thromb Vasc Biol 31:1963-72. 2011
    b>Eicosapentaenoic acid (EPA) has been shown to have beneficial effects on cardiovascular diseases, although the precise mechanism is unknown. We investigated the effect of EPA on the regression of atherosclerosis.
  83. ncbi Fish oil supplementation modulates immune function in healthy infants
    Camilla T Damsgaard
    Department of Human Nutrition, Faculty of Life Sciences, Copenhagen University, 1958 Frederiksberg, Denmark
    J Nutr 137:1031-6. 2007
    ..The implications for later health need further investigation...
  84. pmc Effect of fish oil on arrhythmias and mortality: systematic review
    Hernando Leon
    Epidemiology Coordinating and Research EPICORE Centre, Edmonton, AB, Canada
    BMJ 337:a2931. 2008
    To synthesise the literature on the effects of fish oil-docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)-on mortality and arrhythmias and to explore dose response and formulation effects.
  85. ncbi Early dissimilar fates of liver eicosapentaenoic acid in rats fed liposomes or fish oil and gene expression related to lipid metabolism
    Maud Sabine Cansell
    Laboratoire TREFLE UMR 8508, ISTAB, Universite Bordeaux 1, Talence Cedex, France
    Lipids 44:237-47. 2009
    The study was undertaken to determine whether eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), esterified in phospholipids (PL) as liposomes or in triglycerides (TG) as oil, exhibited comparable fates in ..
  86. ncbi Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:2991-7. 2004
    ..01) more than the LA Diet. Changes in CRP and VCAM-1 were inversely associated with changes in serum eicosapentaenoic acid (EPA) (r = -0.496, P = 0.016; r = -0.418, P = 0.047), or EPA plus docosapentaenoic acid (r = -0.409, P = 0...
  87. ncbi Effect of eicosapentaenoic acid (EPA) on expression of a lipid mobilizing factor in adipose tissue in cancer cachexia
    S T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Prostaglandins Leukot Essent Fatty Acids 72:409-14. 2005
    ..The anti-cachectic agent eicosapentaenoic acid (EPA) (0...
  88. ncbi Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus
    Aileen M Lynch
    Trinity College Institute of Neuroscience, Physiology Department, Trinity College, Dublin 2, Ireland
    Neurobiol Aging 28:845-55. 2007
    ..Treatment of aged rats with eicosapentaenoic acid (EPA) attenuates these changes and we suggest that IL-4 mediates the action of EPA...
  89. ncbi The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function
    Anne Barden
    Cardiovascular Research Center, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Western Australia, Australia
    Free Radic Res 45:469-76. 2011
    ..rat aortic vascular reactivity and human platelet aggregation in response to 14 oxidation products of AA, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and α-linolenic acid (ALA) compared with 15-F₂(t)-IsoP...
  90. ncbi Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review
    Katalin Fekete
    Department of Pediatrics, University of Pecs, Pecs, Hungary
    Am J Clin Nutr 89:2070S-2084S. 2009
    ..The availability of reliable biomarkers of n-3 (omega-3) long-chain polyunsaturated fatty acid (LCPUFA) status is a prerequisite for linking dietary n-3 LCPUFA status to clinical outcomes...
  91. ncbi Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice
    Naoki Tanaka
    Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Japan
    Biochem Pharmacol 80:1601-12. 2010
    b>Eicosapentaenoic acid (EPA) in fish oil is known to improve hepatic steatosis. However, it remains unclear whether such action of EPA is actually caused by peroxisome proliferator-activated receptor α (PPARα) activation...
  92. ncbi Eicosapentaenoic acid decreases expression of anandamide synthesis enzyme and cannabinoid receptor 2 in osteoblast-like cells
    Heather L Hutchins
    Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, IN 47907, USA
    J Nutr Biochem 22:195-200. 2011
    ..Therefore, we hypothesized that n-3 PUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which reduce AA in cells, could lower AEA in osteoblasts by altering ..
  93. pmc Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse
    Shu Wang
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Atherosclerosis 204:147-55. 2009
    ..receptor null mice (LDLr-/-) were used to assess the effect of different ratios of dietary omega-6 PUFA to eicosapentaenoic acid plus docosahexaenoic acid (omega-6:EPA+DHA) on atherogenesis and inflammatory response...
  94. ncbi Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial
    Kortaro Tanaka
    Department of Neurology, Toyama University Hospital, 2630 Sugitani, Toyama, Toyama, 930 0194, Japan
    Stroke 39:2052-8. 2008
    The JELIS trial examined the preventive effect of eicosapentaenoic acid (EPA) against coronary artery diseases...
  95. ncbi Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products
    Masayuki Wada
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:22254-66. 2007
    ..are produced in vivo both from the omega 6 fatty acid arachidonic acid (AA) and the omega 3 fatty acid eicosapentaenoic acid (EPA)...
  96. ncbi Neurological benefits of omega-3 fatty acids
    S C Dyall
    British College of Osteopathic Medicine, Lief House, 120 122 Finchley Road, NW5 5HR, London, UK
    Neuromolecular Med 10:219-35. 2008
    ..Furthermore, there is increasing evidence that increased intake of the long-chain omega-3 PUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may confer benefits in a variety of psychiatric and neurological ..
  97. ncbi Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 81:223-31. 2009
    ..of placebo-controlled intervention trials, a higher daily DHA dose in the order of 1000-1500 mg/d in a 2:1 eicosapentaenoic acid (EPA, 20:5n-3):DHA ratio may be optimal for the treatment of established affective disorders...
  98. pmc Antiobesity effect of eicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis
    Ayumi Sato
    Development Research, Pharmaceutical Research Center, Mochida Pharmaceutical, Shizuoka, Japan
    Diabetes 59:2495-504. 2010
    Given the pleiotropic effect of eicosapentaenoic acid (EPA), it is interesting to know whether EPA is capable of improving obesity. Here we examined the anti-obesity effect of EPA in mice with two distinct models of obesity.
  99. ncbi Dietary reference intakes for DHA and EPA
    Penny M Kris-Etherton
    Department of Nutritional Sciences, The Pennsylvania State University, 319 Chandlee Laboratory, University Park, PA 16802, USA
    Prostaglandins Leukot Essent Fatty Acids 81:99-104. 2009
    Various organizations worldwide have made dietary recommendations for eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and fish intake that are primarily for coronary disease risk reduction and triglyceride (TG) lowering...
  100. ncbi Dietary intake of long-chain omega-3 polyunsaturated fatty acids: contribution of meat sources
    Peter Howe
    Nutritional Physiology Research Centre, School of Health Sciences, University of South Australia, Adelaide, Australia
    Nutrition 22:47-53. 2006
    ..We examined the relative contributions of meat and fish to the dietary intakes of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFAs)...
  101. ncbi Resolvin E1 protects the rat heart against reperfusion injury
    K T Keyes
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Physiol Heart Circ Physiol 299:H153-64. 2010
    ..of the present study was to assess whether resolvin E1 (RvE1), an anti-inflammatory mediator derived from eicosapentaenoic acid, would limit myocardial infarct size in the rat...

Research Grants63

  1. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..including CD11c expression, in obese mice and humans;and its modulation by weight loss and by dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA);Aim 2...
  2. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..first major evaluation of the role of vitamin D and long-chain marine omega-3 polyunsaturated fatty acid (eicosapentaenoic acid [EPA] plus docosahexaenoic acid [DHA]) supplementation on obstructive and infectious respiratory disease ..
  3. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ..factorial trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements to study effects upon autoimmune disease incidence, ..
  4. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..We propose to evaluate the impact of vitamin D3 (2,000 IU/day) and marine omega-3 fatty acids (1gm/d eicosapentaenoic acid [EPA]+840mg/d docosahexaenoic acid [DHA], in a 1...
  5. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2012
    ..g., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), on colon cancer. In contrast, dietary lipids rich in n-6 PUFA, e.g...
  6. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
    ..b>Eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA) are I-3 fatty acids, known to play an anti- inflammatory role through ..
  7. Obesity and Asthma: Genetics and Nutrigenetic Response to Omega-3 Fatty Acids
    Jason E Lang; Fiscal Year: 2013
    ..In aim #2, we will determine the impact of fish oil-derived Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA) on asthma control among obese asthmatics...
  8. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and/or marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements, to advance knowledge and test the effects of vitamin D3 (..
  9. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..a randomized, placebo-controlled clinical trial of vitamin D3 (cholecalciferol) and omega-3 fatty acids (eicosapentaenoic acid plus docosahexaenoic acid) to prevent the development and progression of diabetic kidney disease (DKD)...
  10. A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
    Jae H Kang; Fiscal Year: 2013
    ..D (vitamin D3 [cholecalciferol], 2000 IU/day) and marine omega-3 fatty acid (docosahexaenoic acid + eicosapentaenoic acid, 1000 mg/day) supplements for slowing cognitive decline...
  11. VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ..by applicant): We propose to evaluate the effects of vitamin D3 (1600 IU/day) and omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], 1g/day) supplements on risk of late-life depression and depressive ..
  12. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
    ..will investigate the role of hormone signaling (specifically, IGF1) and the metabolism of a dietary lipid (eicosapentaenoic acid, an omega-3 fatty acid commonly found in fish oil) in the proliferation and survival of breast cancer ..
  13. VITamin D and omegA-3 triaL (VITAL)
    JOANN ELISABETH MANSON; Fiscal Year: 2013
    ..factorial trial of vitamin D (in the form of vitamin D3 [cholecalciferol]) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements in the primary prevention of cancer and cardiovascular ..
  14. Diabetes Prevention in the Vitamin D and Omega-3 Trial
    Yiqing Song; Fiscal Year: 2013
    ..to evaluate the balance of benefits and risks of vitamin D3 (2,000 IU/day) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], 1g/day) supplements in reducing risk of T2D in the setting of an NIH-..
  15. Effects of Dietary Omega-3 Fatty Acids on Akt Signaling in Prostate Cancer
    Yong Q Chen; Fiscal Year: 2013
    ..fatty acid (PUFA): the botanic ?3 PUFA [1-linolenic acid (1LNA, 18:3n-3)] and the marine I3 PUFA [eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3)]...
  16. Use or Metabolomic Markers of Response to Fish Oil Supplementation to Identify Ef
    CHARLES BOLT STEPHENSEN; Fiscal Year: 2011
    ..focusing on arachadonic acid (AA) and the two principal omega-3 fatty acids from fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These data are available from the parent study...
  17. VITAL-AMD: Prevention of AMD in the VITamin D and OmegA-3 Trial
    Debra A Schaumberg; Fiscal Year: 2013
    ..trial designed to test vitamin D (vitamin D3 [cholecalciferol], 2000 IU/d) and marine omega-3 fatty acid (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA], 1 g/d) supplements in the primary prevention of cancer and ..
  18. Omega-3 Fatty Acids for Prevention of Dry Eye Disease: VITAL-DED
    Debra A Schaumberg; Fiscal Year: 2013
    ..a randomized, double-blind, placebo-controlled, 2x2 factorial trial to test marine omega-3 FA (465 mg/d eicosapentaenoic acid + 375 mg/d docosahexaenoic acid) and vitamin D3 (cholecalciferol, 2000 IU/d) supplements in the primary ..
  19. Omega-3 Fatty Acid Effects on Pancreatitis and Adenocarcinoma Development
    Christopher A Jolly; Fiscal Year: 2013
    ..the cyclooxygenase 2 (COX-2) transgenic mouse model fed diets enriched in either the omega-3 fatty acid eicosapentaenoic acid (EPA) or the omega-6 fatty acid linoleic acid prior to the onset of pancreatitis...
  20. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..for intakes of polyunsaturated and monounsaturated fats, the n-3 fatty acids, alpha-linolenic acid and eicosapentaenoic acid, vitamin C, and vitamin E supplement use were unclear or marginally significant...
  21. Specialized lipid mediators and mechanisms of resolution in vascular injury
    Michael S Conte; Fiscal Year: 2013
    ..is mediated by specialized pro-resolving lipid mediators derived from polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
  22. Regulation of ChemR23 in Resolution of Inflammation
    MARCELO DE OLIVEIRA FREIRE; Fiscal Year: 2013
    ..mediated by endogenous lipids, including, resolvin E1 (RvE1), derived from the [unreadable]-3 fatty acid, eicosapentaenoic acid (EPA)...
  23. Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and Hypertension
    Howard D Sesso; Fiscal Year: 2013
    ..trial, will test 2000 IU/day of vitamin D (as vitamin D3 [cholecalciferol]) and 1 g/day of marine I-3 FA (eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) supplements on incident cardiovascular disease and cancer in 20,000 ..
  24. A platform for individualized nutritional therapy in Alzheimer's disease
    Gene L Bowman; Fiscal Year: 2012
    ..and F2 Isoprostanes as a marker of oxidative stress, the omega 3 fatty acids docosahexaenoic acid and eicosapentaenoic acid, and cholesterol. This training will provide a platform for Dr...
  25. Treatment of Skeletal Muscle Dysfunction in ICU Patients
    Gerald S Supinski; Fiscal Year: 2013
    ..in critically ill patients can be attenuated by administration of hydroxymethylbutyrate (HMB) and/or eicosapentaenoic acid (EPA)...
  26. Lipid Peroxidation and Antioxidant Mechanisms
    NED ALLEN PORTER; Fiscal Year: 2012
    ..Project 2 explores the chemistry and biology of eicosapentaenoic acid (EPA), a fatty acid prominent in fish oil, and explores the hypothesis that EPA oxidation products may ..
  27. Effect of Omega-3 Fatty Acids on Cancer Stem Cells
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Eicosapentaenoic acid (EPA) is an omega (?)-3 polyunsaturated fatty acid (PUFA) whose consumption has increased over time...
  28. The VITAL Rhythm Study
    Christine M Albert; Fiscal Year: 2013
    ..application, we propose to evaluate the balance of benefits and risks of marine omega-3 fatty acid (840 mg eicosapentaenoic acid [EPA] + docosahexaenoic acid [DHA]) and vitamin D3 (2,000 IU/day cholecalciferol) on AF incidence in the ..
  29. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..the hypotriglyceridemic effects of long-chain omega-3 polyunsaturated fatty acids are due primarily to eicosapentaenoic acid or docosahexaenoic acid by determining if these purified fatty acids (as dietary constituents) prevent ..
  30. Omega-3 Fatty Acids and Hepatic Carcinogenesis
    Tong Wu; Fiscal Year: 2013
    ..The primary effector molecules are thought to be docosahexaenoic acid (DHA, 22:6, omega-3) and eicosapentaenoic acid (EPA, 20:5, omega-3)...
  31. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2007
    ..protein breakdown with ND, the addition of an inhibitor of the ubiquitin proteasome mediated proteolysis (eicosapentaenoic acid; EPA) to IGF-1 infusion will further attenuate or reverse muscle fiber atrophy...
  32. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    ..experiments will compare the utilization and short-term metabolic effects of palmitic acid, linoleic acid, eicosapentaenoic acid (C20:5 omega- 3), and docosahexaenoic acid (C22:6 omega-3) in isolated hepatocytes plus or minus insulin (..
  33. OMEGA-3 FATTY ACIDS AND THE CEREBRAL CIRCULATION
    EARL ELLIS; Fiscal Year: 1993
    ..Our pilot data suggest the that n-3 fatty acid eicosapentaenoic acid (EPA) is metabolized by brain tissue and that it produces less arteriolar dilation compared to AA...
  34. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2006
    ..Two omega-3 fatty acids in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
  35. METABOLISM OF PLATELET ACTIVATING FACTOR
    ROBERT WYKLE; Fiscal Year: 1993
    ..studies of PMN from monkeys maintained on a fish-oil-enriched diet, we found a major shift from AA to eicosapentaenoic acid in the acylation of lysoPAF...
  36. EICOSAPENTAENOIC ACID: MECHANISM OF ACTION IN PLATELETS
    MANFRED STEINER; Fiscal Year: 1990
    We propose to examine the mechanism of action of eicosapentaenoic acid (EPA; 20:5 (n-3)) in platelets of normal men and in a select group of hypercholesterolemic patients...
  37. Omega-3 Fatty Acids in Adolescents with Depression
    Vilma Gabbay; Fiscal Year: 2007
    ..the efficacy and tolerability of the omega-3 fatty acids (omega-3FA) docosahexaenoic acid (DMA) and eicosapentaenoic acid (EPA) in adolescents with major depression (MOD). Rationale...
  38. Fish Oil Modulation of Tumor Inflammation
    NOCIF ESPAT; Fiscal Year: 2006
    ..anti-inflammatory treatment strategies for patients with progressive malignancy using (nutritional) eicosapentaenoic acid, (EPA)) and/or (pharmacologic) selective cyclo-oxygenase-II (COX-II) inhibitor agents...
  39. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    MOHAMED BAYORH; Fiscal Year: 1990
    ..of the proposed studies are threefold: a) to examine the long term effect of arachidonic acid (AA) and eicosapentaenoic acid (EPA) on blood pressure of hypertensive rats (SHR) and stroke prone spontaneously hypertensive rats (SHRSP)..
  40. OMEGA-3 FATTY ACIDS, DIABETES AND CARDIOVASCULAR RISK
    William Harris; Fiscal Year: 2001
    ..The long-chain, marine omega-3 fatty acids [primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] have recently been shown to reduce total mortality by 20 percent in ..
  41. RENAL EFFECTS OF DIETARY FAT IN EXPERIMENTAL DIABETES
    JOY LOGAN; Fiscal Year: 1992
    ..Preliminary data are presented which indicate that a diet rich in eicosapentaenoic acid, a polyunsaturated fat found in fish oil, interferes with arachidonic acid metabolism and markedly ..
  42. EICOSAPENTAENOIC ACID FOR TOPICAL SKIN DISEASE TREATMENT
    RODNER WINGET; Fiscal Year: 1993
    The long-term goal of this project is to develop an anti-inflammatory drug, containing eicosapentaenoic acid (EPA) isolated from cultured marine algae, for topical treatment of psoriasis, eczema, and acne...
  43. DOCOSAHEXAENOIC ACID FROM MICROALGAE
    DAVID KYLE; Fiscal Year: 1992
    ..formulas with fish oils have led to rejection due to the strong fishey odor and taste and high levels of eicosapentaenoic acid (EPA)...
  44. EICOSAPENTANOIC ACID FOR TOPICAL SKIN CANCER TREATMENT
    RODNER WINGET; Fiscal Year: 1993
    The long term goal of this research is to develop topical therapy for cancer with eicosapentaenoic acid (EPA), which has been shown to have anti-inflammatory and anti-tumorigenic properties...
  45. Dietary Factors in Relation to Prenatal and Postpartum Depression
    ANSHU MOHLLAJEE; Fiscal Year: 2007
    ..Omega-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are important in neural tissues and affect receptor function, neurotransmitter uptake, and signal ..
  46. MECHANISM OF DISEASE PREVENTION BY N 3 FATTY ACIDS
    Alexander Leaf; Fiscal Year: 1999
    ..Of the dietary PUFAs two omega-3 (n-3) PUFA, eicosapentaenoic acid (C2O:5n-3, EPA) and docosahexaenoic (c22:6n-3) are the most potent in their antiarrhythmic effects, ..
  47. EICOSAPENTAENOIC ACID: ALGAE CULTURE & EXTRACTION
    RODNER WINGET; Fiscal Year: 1991
    ..The products described in this proposal are three forms of eicosapentaenoic acid, an essential fatty acid with therapeutic and prophylactic applications for cardiovascular patients...
  48. EICOSAPENTAENOIC ACID FOR TOPICAL SKIN DISEASE TREATMENT
    RODNER WINGET; Fiscal Year: 1991
    ..the chemistry for isolating a species of polar lipid from marine algae that contain high concentrations of eicosapentaenoic acid (EPA), (2) identify the structure of the product by chemical and spectral means, and (3) test the ..
  49. ALGAL EPA AEROSOL TO INHIBIT BRONCHIAL INFLAMMATION
    RODNER WINGET; Fiscal Year: 1993
    The long term goal of this research is to develop topical anti- inflammatory therapy for asthma with eicosapentaenoic acid (EPA) extracted from marine algae. EPA has no known side effects other than a mild increase in bleeding time...
  50. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009
    ..diabetes &atherosclerosis]: Our studies have focused on dietary polyunsaturated fatty acid (PUFA: eicosapentaenoic acid [20:5n3] and docosahexaneoic acid [22:6n3]) control of three hepatic transcription factors, sterol ..
  51. EICOSAPENTAENOIC ACID FROM HETEROTROPHIC MICROALGAE
    DAVID KYLE; Fiscal Year: 1991
    ..If this strategy is unsuccessful, total transformation or mutagenesis and selection will be attempted. In phase 2, the procedure will be optimized using the developed strain to prepare for commercialization of a "designer oil."..
  52. Prevention of Diabetes with Nutritional Supplements
    Peter Havel; Fiscal Year: 2007
    ..the following specific aims: Specific Aim 1: We hypothesize that supplementation with omega 3 fatty acid eicosapentaenoic acid (EPA) will activate PPARalpha, gamma and delta and prevent or delay the onset of T2DM...
  53. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  54. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  55. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  56. Omega-3 Fatty Acids for Treatment of Major Depression
    David Mischoulon; Fiscal Year: 2010
    ..e. integrates biological findings with treatment in order to have a direct impact on the clinical practice of psychiatry. ..
  57. Omega-3 Fatty Acids in the Treatment of Depression
    David Mischoulon; Fiscal Year: 2005
    ..It is hoped that this project will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator. ..
  58. Cholesterol and fatty acids in cocaine addiction relapse
    Laure Buydens Branchey; Fiscal Year: 2004
    ..If our preliminary findings are confirmed, the use of fatty acids supplements or changes in dietary habits could have a significant potential in the prevention of relapse in a subgroup of cocaine addicts. ..
  59. EFFECTS OF BUSPIRONE IN WITHDRAWAL FROM OPIATES
    Laure Buydens Branchey; Fiscal Year: 2002
    ..Buspirone has additional advantages. It is not sedating, has no withdrawal symptoms, has no abuse potential, does not potentiate central nervous system depressants and does not induce psychomotor impairment. ..
  60. Neuropeptide Y for Cancer-Associated Anorexia
    Aminah Jatoi; Fiscal Year: 2003
    ..These two pilot studies will allow us to lay the groundwork for such larger trials. Our ultimate goal is to help cancer patients who suffer from anorexia. ..